Skin depression repairing injection and use method thereof

Abstract

The invention discloses a skin depression repair injection and a use method thereof, and relates to the technical field of skin repair. The radix angelicae sinensis extract can achieve the effects of expanding blood vessels and improving blood circulation after being used, the radix sophorae flavescentis extract contains various antioxidants and can prevent free radicals from damaging skin cells and protect skin health, and radix angelicae sinensis and radix sophorae flavescentis are good in safety and free of toxic and side effects; the poly-bis-lactic acid stimulates generation of collagen and helps to tighten a loose fascia layer, so that the facial contour is improved, glycolic acid can effectively enter the skin, stimulate cell viability, promote synthesis of elastic fibers and collagen in dermis, reduce fine lines and wrinkles, make the skin more compact and elastic, and make the skin more smooth and elastic. Components in the collagen peptide can directly permeate into the bottom layer of the skin and can be combined with surrounding tissues to stimulate the body to generate collagen and promote normal growth of skin cells, so that the collagen peptide is beneficial to assisting in repairing scars.

Description

Technical Field

[0001] The present invention relates to the technical field of skin repair, and in particular to a skin depression repair injection and a use method thereof. Background Art

[0002] In recent years, with the continuous improvement of people's living standards, people pay more and more attention to skin beauty, especially facial skin beauty. Depressed scars, also known as depressed scars, refer to depressed scars caused by skin tissue defects. They are usually caused by acne, surgery, traumatic infection, chickenpox, smallpox and other diseases, which cause the loss of skin collagen and elastin, and leave permanent depressed scars, which seriously affect people's facial appearance.

[0003] Injection beauty mainly involves injecting substances into the local part of the human body to correct skin defects. It has the advantages of minimally invasive (non-invasive), high safety, rapid onset, and individuality. It includes botulinum toxin injection, sodium hyaluronate, autologous fat transplantation, autologous plasma injection, and collagen filling. Botulinum toxin, also known as botulinum toxin, is a bacterial endotoxin secreted by the deadly botulinum toxin. It is highly toxic. The greater the toxicity, the more obvious the effect, but it can cause unnatural facial muscles or even facial paralysis. Autologous fat absorbs excess subcutaneous fat cells from certain parts of the human body. The extracted mixture is purified and injected with drugs to obtain composite fat particles. The complete granular fat cells are selected and then transplanted to the part where fat filling is required by injection. However, autologous fat filling also has limitations, such as postoperative fat absorption, and complications such as fibrous nodules, calcification, infection, and lipomas are prone to occur. Autologous fibroblast lysate is a fibroblast suspension made from autologous skin, which is cultured in vitro and injected into the sunken part. The effect is obvious but it can cause skin damage. For this reason, we propose a skin sunken repair injection and its use method. Summary of the invention

[0004] The purpose of the present invention is to solve the problems mentioned in the above background technology, and provide a skin depression repair injection and a method of using the same.

[0005] In order to achieve the above-mentioned purpose, the present invention specifically adopts the following technical solutions:

[0006] A skin depression repair injection, which consists of the following ingredients in percentage by weight: 5% to 10% of angelica extract, 5% to 10% of sophora flavescens extract, 5% to 10% of poly(lactic acid), 8% to 10% of glycolic acid, 22% to 28% of collagen peptide, 11% to 18% of sodium hyaluronate, 5% to 10% of biocolloid dispersant, 2% to 5% of cross-linking agent, and the balance is water.

[0007] Furthermore, the repair injection is composed of the following ingredients in weight percentage: 5% angelica extract, 10% sophora flavescens extract, 10% poly(lactic acid), 10% glycolic acid, 28% collagen peptide, 18% sodium hyaluronate, 10% biocolloid dispersant, 5% cross-linking agent, and the balance is water.

[0008] Furthermore, the repair injection is composed of the following ingredients in percentage by weight: 7.5% angelica extract, 7.5% sophora flavescens extract, 7.5% poly(lactic acid) 7.5%, 9% glycolic acid, 25% collagen peptide, 14.5% sodium hyaluronate, 7.5% biocolloid dispersant, 2.5% cross-linking agent, and the balance is water.

[0009] Furthermore, the repair injection is composed of the following ingredients in weight percentage: 10% angelica extract, 5% sophora flavescens extract, 5% poly(lactic acid), 8% glycolic acid, 22% collagen peptide, 11% sodium hyaluronate, 5% biocolloid dispersant, 2% cross-linking agent, and the balance is water.

[0010] A method for preparing a skin depression repairing liquid, the preparation method comprising the following steps:

[0011] S1. Prepare raw material 1, take Chinese Angelica and Sophora flavescens and slice them;

[0012] S2, cleaning raw material 1, placing the sliced ​​angelica and sophora flavescens in a cleaning machine for cleaning;

[0013] S3, drying raw material 1, placing the cleaned raw material 1 in a dryer for drying;

[0014] S4, extracting raw material 1, placing the dried raw material 1 in an extraction machine for extraction operation;

[0015] S5. Prepare raw material 2, dissolve poly(dextrin-lactic acid), glycolic acid, collagen peptide, sodium hyaluronate, biocolloid dispersant and cross-linking agent in water, and mix them in a mixer to prepare mixed solution 1;

[0016] S6, mixing, placing the extract of raw material one and the mixture of raw material two in a mixer to mix, to obtain a mixed solution two;

[0017] S7, filtering through a 0.2 μm filter membrane to obtain an injection solution;

[0018] S8. Pack the prepared injection solution into ampoules.

[0019] Furthermore, the cleaning machine in S2 is an ultrasonic cleaning machine, the ultrasonic power is 600W-1000W, the stirring speed is 900-1300rpm / min, and the stirring time is 8-35 minutes.

[0020] Furthermore, the dryer in S3 is a rotary dryer with a power of 800W to 1000W, a capacity of 10KG, a drying temperature of 100-200°C, and a drying time of 3 to 4 hours.

[0021] Furthermore, the extraction machine in S4 is a centrifugal extraction machine for extraction, the extraction temperature is 60-80°C, the pressure is 40-60MPa, and the extraction time is 3-5 hours.

[0022] Furthermore, the mixers in S5 and S6 are both ultrasonic mixers with a frequency of 20K to 28K, a power of 1KW to 3KW, and an amplitude of 60mm to 120mm.

[0023] A method for using a skin depression repairing liquid comprises the following steps:

[0024] A1. Detect the depressions on the user's facial skin;

[0025] A2. Use medical alcohol to wipe the user's face for disinfection, and then inject anesthetic for anesthesia;

[0026] A3. Inject the repair injection solution into the subcutaneous fascia layer at the depression point;

[0027] A4. Press the depressed point to peel off the subcutaneous fascia layer at the depressed point.

[0028] The beneficial effects of the present invention are as follows:

[0029] 1. The angelica extract of the present invention can dilate blood vessels and increase blood circulation after use. The sophora flavescens extract contains a variety of antioxidants, which can prevent free radicals from damaging skin cells and protect skin health. In addition, angelica and sophora flavescens are safe and have no toxic side effects.

[0030] 2. The poly(dioxylactic acid) of the present invention helps tighten the loose fascia layer by stimulating the production of collagen, thereby improving the facial contour. Hydroxyacetic acid can effectively penetrate into the skin, stimulate cell vitality, promote the synthesis of elastic fibers and collagen in the dermis, reduce fine lines and wrinkles, and make the skin firmer and more elastic. The ingredients in collagen peptides can directly penetrate the bottom layer of the skin and can combine with surrounding tissues to stimulate the body to produce collagen and promote the normal growth of skin cells, thus helping to assist in the repair of scars. Sodium hyaluronate, due to its small molecule and strong permeability, can more effectively penetrate into skin cells and promote cell metabolism and repair.

[0031] 3. The present invention injects the injection solution into the target area, which has strong permeability and can avoid the abnormality of local contour morphology, with less pain and risk. The skin becomes smooth, bright and elastic, and the beauty effect is remarkable. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 It is a work flow chart of the preparation of the injection solution in the present invention;

[0033] Figure 2 It is a workflow diagram of the method used in the present invention. DETAILED DESCRIPTION

[0034] To make the purpose, technical solution and advantages of the embodiments of the present invention more clear, the technical solution in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention.

[0035] The invention provides a skin depression repairing injection, which consists of the following components: 5%-10% of angelica extract, 5%-10% of sophora flavescens extract, 5%-10% of poly(lactic acid), 8%-10% of glycolic acid, 22%-28% of collagen peptide, 11%-18% of sodium hyaluronate, 5%-10% of biocolloid dispersant, 2%-5% of cross-linking agent, and the balance is water.

[0036] Angelica sinensis, according to the 2020 edition of the "Chinese Pharmacopoeia": Nature and flavor and meridians: sweet, pungent, warm, entering the liver, heart, and spleen meridians; Functions and indications: tonifying blood and activating blood circulation, regulating menstruation and relieving pain, after use, it can dilate blood vessels and increase blood circulation.

[0037] Sophora flavescens, according to the 2020 edition of the "Chinese Pharmacopoeia": Nature and flavor and meridians: bitter, cold, entering the heart, liver, stomach, large intestine, and bladder meridians; Functions and indications: clearing heat and drying dampness. Sophora flavescens also contains a variety of antioxidants, which can prevent free radical damage to skin cells and protect skin health.

[0038] Poly(dioxylactic acid) can stimulate the body's own collagen production, increase the firmness and elasticity of the skin; it acts on the fascia layer, stimulates the production of collagen, helps tighten the loose fascia layer, and thus enhances the facial contour; combined with porous sponge-like microsphere technology, the pores inside the microspheres allow nutrients and drugs to penetrate, further promoting the production of collagen and elastic fibers.

[0039] Hydroxyacetic acid can effectively penetrate into the skin and stimulate cell vitality. It can soften the stratum corneum and improve dry and flaky skin. It can adjust the moisture of the epidermis to make the skin smoother, softer and glowing with a healthy luster. At the same time, it can promote the synthesis of elastic fibers and collagen in the dermis, reduce fine lines and wrinkles, and make the skin firmer and more elastic.

[0040] The ingredients in collagen peptides can directly penetrate the bottom layer of the skin and combine with surrounding tissues to stimulate the body to produce collagen and promote the normal growth of skin cells, thus helping to repair scars.

[0041] Because of its small molecule and strong permeability, sodium hyaluronate can penetrate into skin cells more effectively and promote cell metabolism and repair.

[0042] The application of biological colloid dispersants can induce the proliferation of epithelial cells, which can promote the recovery of wounds. It will not affect the wound surface and will not cause inflammation or infection in the wound.

[0043] The cross-linking agent enables the drug solution to be slowly absorbed by the body when it is filled inside the tissue, thus maintaining a good filling state.

[0044] A method for preparing a skin depression repairing liquid, the preparation method comprising the following steps:

[0045] S1. Prepare raw material 1, take Chinese Angelica and Sophora flavescens and slice them;

[0046] S2, cleaning raw material 1, placing the sliced ​​angelica and sophora flavescens in a cleaning machine for cleaning;

[0047] S3, drying raw material 1, placing the cleaned raw material 1 in a dryer for drying;

[0048] S4, extracting raw material 1, placing the dried raw material 1 in an extraction machine for extraction operation;

[0049] S5. Prepare raw material 2, dissolve poly(dextrin-lactic acid), glycolic acid, collagen peptide, sodium hyaluronate, biocolloid dispersant and cross-linking agent in water, and mix them in a mixer to prepare mixed solution 1;

[0050] S6, mixing, placing the extract of raw material one and the mixture of raw material two in a mixer to mix, to obtain a mixed solution two;

[0051] S7, filtering through a 0.2 μm filter membrane to obtain an injection solution;

[0052] S8. Pack the prepared injection solution into ampoules.

[0053] In this embodiment, preferably, the cleaning machine in S2 is an ultrasonic cleaning machine, the ultrasonic power is 600W to 1000W, the stirring speed is 900 to 1300 rpm / min, and the stirring time is 8 to 35 minutes.

[0054] In this embodiment, preferably, the dryer in S3 is a rotary dryer with a power of 800W to 1000W, a capacity of 10KG, a drying temperature of 100-200°C, and a drying time of 3 to 4 hours.

[0055] In this embodiment, preferably, the extractor in S4 is a centrifugal extractor for extraction, the extraction temperature is 60-80° C., the pressure is 40-60 MPa, and the extraction time is 3-5 hours.

[0056] In this embodiment, preferably, the mixers in S5 and S6 are both ultrasonic mixers with a frequency of 20K to 28K, a power of 1KW to 3KW, and an amplitude of 60mm to 120mm.

[0057] Example 1

[0058] See also Figure 1 - Figure 2 A skin depression repair injection, which is composed of the following ingredients by weight: 5% angelica extract, 10% sophora flavescens extract, 10% poly (dextrin) lactic acid, 10% glycolic acid, 28% collagen peptide, 18% sodium hyaluronate, 10% biocolloid dispersant, 5% cross-linking agent, and the balance is water.

[0059] A method for preparing a skin depression repairing liquid, the preparation method comprising the following steps:

[0060] S1. Prepare raw material 1, take Angelica sinensis and Sophora flavescens and slice them.

[0061] S2. Cleaning the raw materials: Place the sliced ​​angelica and sophora flavescens in a cleaning machine for cleaning; the cleaning machine is an ultrasonic cleaning machine with an ultrasonic power of 600 W, a stirring speed of 900 rpm / min, and a stirring time of 8 minutes.

[0062] S3, drying raw material 1, placing the cleaned raw material 1 in a dryer for drying; the dryer is a rotary dryer with a power of 800W, a capacity of 10KG, a drying temperature of 100°C, and a drying time of 3 hours.

[0063] S4, extracting raw material 1, placing the dried raw material 1 in an extractor for extraction; the extractor is a centrifugal extractor, the extraction temperature is 60°C, the pressure is 40MPa, and the extraction time is 3 hours.

[0064] S5. Prepare raw material 2, dissolve poly(dextrin-lactic acid), glycolic acid, collagen peptide, sodium hyaluronate, biocolloid dispersant and cross-linking agent in water, and mix them in a mixer to prepare mixed solution 1; the mixer is an ultrasonic mixer with a frequency of 20K, a power of 1KW and an amplitude of 60mm.

[0065] S6. Mixing: placing the extract of raw material one and the mixture of raw material two in a mixer for mixing to obtain a mixed solution two; the mixer is an ultrasonic mixer with a frequency of 20K, a power of 1KW, and an amplitude of 60mm.

[0066] S7, filtering through a 0.2 μm filter membrane to obtain an injection solution;

[0067] S8. Pack the prepared injection solution into ampoules.

[0068] Example 2

[0069] See also Figure 1 - Figure 2 The difference between this embodiment and embodiment 1 is that the ratio of each component is different. A skin depression repair injection, calculated by weight percentage, is composed of the following components: 7.5% angelica extract, 7.5% sophora flavescens extract, 7.5% poly (dextrin) lactic acid, 9% glycolic acid, 25% collagen peptide, 14.5% sodium hyaluronate, 7.5% biocolloid dispersant, 2.5% cross-linking agent, and the balance is water.

[0070] A method for preparing a skin depression repairing liquid, the preparation method comprising the following steps:

[0071] S1. Prepare raw material 1, take Angelica sinensis and Sophora flavescens and slice them.

[0072] S2. Cleaning the raw materials 1. Place the sliced ​​angelica and sophora flavescens in a cleaning machine for cleaning; the cleaning machine is an ultrasonic cleaning machine with an ultrasonic power of 800 W, a stirring speed of 1100 rpm / min, and a stirring time of 30 minutes.

[0073] S3, drying raw material 1, placing the cleaned raw material 1 in a dryer for drying; the dryer is a rotary dryer with a power of 900W, a capacity of 10KG, a drying temperature of 150°C, and a drying time of 3.5 hours.

[0074] S4, extracting raw material 1, placing the dried raw material 1 in an extractor for extraction; the extractor is a centrifugal extractor, the extraction temperature is 70°C, the pressure is 50MPa, and the extraction time is 4 hours.

[0075] S5. Prepare raw material 2, dissolve poly(dextrin) lactic acid, glycolic acid, collagen peptide, sodium hyaluronate, biocolloid dispersant and cross-linking agent in water, and mix them in a mixer to prepare mixed solution 1; the mixer is an ultrasonic mixer with a frequency of 24K, a power of 2KW and an amplitude of 90mm.

[0076] S6, mixing, placing the extract of raw material one and the mixture of raw material two in a mixer for mixing to obtain mixed solution two; the mixer is an ultrasonic mixer with a frequency of 24K, a power of 2KW, and an amplitude of 90mm.

[0077] S7, filtering through a 0.2 μm filter membrane to obtain an injection solution;

[0078] S8. Pack the prepared injection solution into ampoules.

[0079] Example 3

[0080] See also Figure 1 - Figure 2 The difference between this embodiment and embodiment 1 and embodiment 2 is that the ratio of each component is different. A skin depression repair injection is composed of the following components: 10% angelica extract, 5% sophora flavescens extract, 5% poly (dextrin) lactic acid, 8% glycolic acid, 22% collagen peptide, 11% sodium hyaluronate, 5% biocolloid dispersant, 2% cross-linking agent, and the balance is water.

[0081] A method for preparing a skin depression repairing liquid, the preparation method comprising the following steps:

[0082] S1. Prepare raw material 1, take Angelica sinensis and Sophora flavescens and slice them.

[0083] S2. Cleaning the raw materials: Place the sliced ​​angelica and sophora flavescens in a cleaning machine for cleaning; the cleaning machine is an ultrasonic cleaning machine with an ultrasonic power of 1000 W, a stirring speed of 1300 rpm / min, and a stirring time of 35 minutes.

[0084] S3, drying raw material 1, placing the cleaned raw material 1 in a dryer for drying; the dryer is a rotary dryer with a power of 1000W, a capacity of 10KG, a drying temperature of 200°C, and a drying time of 4 hours.

[0085] S4, extracting raw material 1, placing the dried raw material 1 in an extractor for extraction; the extractor is a centrifugal extractor, the extraction temperature is 80°C, the pressure is 60MPa, and the extraction time is 5 hours.

[0086] S5. Prepare raw material 2, dissolve poly(dextrin-lactic acid), glycolic acid, collagen peptide, sodium hyaluronate, biocolloid dispersant and cross-linking agent in water, and mix them in a mixer to prepare mixed solution 1; the mixer is an ultrasonic mixer with a frequency of 28K, a power of 3KW and an amplitude of 120mm.

[0087] S6, mixing, placing the extract of raw material one and the mixture of raw material two in a mixer for mixing to obtain mixed solution two; the mixer is an ultrasonic mixer with a frequency of 28K, a power of 3KW, and an amplitude of 120mm.

[0088] S7, filtering through a 0.2 μm filter membrane to obtain an injection solution;

[0089] S8, packing, filling the prepared injection into ampoules

[0090] Example 4

[0091] A method for using a skin depression repairing liquid comprises the following steps:

[0092] A1. Detect the depressions on the user's facial skin;

[0093] A2. Use medical alcohol to wipe the user's face for disinfection, and then inject anesthetic for anesthesia;

[0094] A3. Inject the repair injection solution into the subcutaneous fascia layer at the depression point;

[0095] A4. Press the depressed point to peel off the subcutaneous fascia layer at the depressed point.

[0096] The injection solution is injected into the target area, which has strong permeability and can avoid abnormal local contour morphology. It is less painful and less risky. The skin becomes smooth, bright and elastic, with significant cosmetic effects.

[0097] The effects of Examples 1 to 3 were examined.

[0098] Test method:

[0099] Thirty rats, half male and half female, were selected and divided into three groups, with 10 rats in each group. The repair solutions of Examples 1 to 3 were injected respectively, and one week was one course of treatment, with injection once a week for four courses of treatment. After the treatment, the rats were scored according to numerical values ​​(1 to 10 points). The higher the score, the better the effect.

[0100] The test results are shown in Table 1:

[0101] Table 1

[0102]

[0103] According to Table 1, Example 2 is the best solution.

[0104] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A skin depression repair injection, characterized in that: The repair injection is composed of the following ingredients in percentage by weight: 5% to 10% angelica extract, 5% to 10% sophora flavescens extract, 5% to 10% poly(lactic acid) 5% to 10%, 8% to 10% glycolic acid, 22% to 28% collagen peptide, 11% to 18% sodium hyaluronate, 5% to 10% biocolloid dispersant, 2% to 5% cross-linking agent, and the balance is water.

2. The skin depression repair injection according to claim 1, characterized in that: The repair injection is composed of the following ingredients in weight percentage: 5% angelica extract, 10% sophora flavescens extract, 10% poly(lactic acid), 10% glycolic acid, 28% collagen peptide, 18% sodium hyaluronate, 10% biocolloid dispersant, 5% cross-linking agent, and the balance is water.

3. The skin depression repair injection according to claim 1, characterized in that: The repair injection is composed of the following ingredients in percentage by weight: 7.5% angelica extract, 7.5% sophora flavescens extract, 7.5% poly(lactic acid), 9% glycolic acid, 25% collagen peptide, 14.5% sodium hyaluronate, 7.5% biocolloid dispersant, 2.5% cross-linking agent, and the balance is water.

4. The skin depression repair injection according to claim 1, characterized in that: The repair injection is composed of the following ingredients in weight percentage: 10% angelica extract, 5% sophora flavescens extract, 5% poly(lactic acid), 8% glycolic acid, 22% collagen peptide, 11% sodium hyaluronate, 5% biocolloid dispersant, 2% cross-linking agent, and the balance is water.

5. A method for preparing the skin depression repairing liquid according to any one of claims 1 to 4, characterized in that: The preparation method comprises the following steps: S1. Prepare raw material 1, take angelica and sophora flavescens and slice them; S2, cleaning raw material 1, placing the sliced ​​angelica and sophora flavescens in a cleaning machine for cleaning; S3, drying raw material 1, placing the cleaned raw material 1 in a dryer for drying; S4, extracting raw material 1, placing the dried raw material 1 in an extraction machine for extraction operation; S5. Prepare raw material 2, dissolve poly(dextrin-lactic acid), glycolic acid, collagen peptide, sodium hyaluronate, biocolloid dispersant and cross-linking agent in water, and mix them in a mixer to prepare mixed solution 1; S6, mixing, placing the extract of raw material one and the mixture of raw material two in a mixer to mix, to obtain a mixed solution two; S7, filtering through a 0.2 μm filter membrane to obtain an injection solution; S8. Pack the prepared injection solution into ampoules.

6. The method for preparing a skin depression repairing injection according to claim 5, characterized in that: The cleaning machine in S2 is an ultrasonic cleaning machine with an ultrasonic power of 600W to 1000W and a stirring speed of 900 to 1000W. 1300rpm / min, stirring time is 8 to 35 minutes.

7. The method for preparing a skin depression repairing injection according to claim 5, characterized in that: The dryer in S3 is a rotary dryer with a power of 800W-1000W, a capacity of 10KG, a drying temperature of 100-200°C, and a drying time of 3-4 hours.

8. The method for preparing a skin depression repairing injection according to claim 5, characterized in that: The extractor in S4 is a centrifugal extractor for extraction, the extraction temperature is 60-80°C, the pressure is 40-60MPa, and the extraction time is 3-5 hours.

9. The method for preparing a skin depression repairing injection according to claim 5, characterized in that: The mixers in S5 and S6 are both ultrasonic mixers with a frequency of 20K to 28K, a power of 1KW to 3KW, and an amplitude of 60mm to 120mm.

10. A method for using the skin depression repairing liquid according to any one of claims 1 to 4, characterized in that: The steps include: A1. Detect the depressions on the user's facial skin; A2. Use medical alcohol to wipe the user's face for disinfection, and then inject anesthetic for anesthesia; A3. Inject the repair injection solution into the subcutaneous fascia layer at the depression point; A4. Press the depressed point to peel off the subcutaneous fascia layer at the depressed point.

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