Gastrodia elata and aloe oral liquid and preparation method thereof

Abstract

The invention belongs to the technical field of biological medicines, and particularly relates to a gastrodia elata aloe oral liquid which comprises the following components: aloe vera gel juice, a gastrodia elata extract, fruit juice, erythritol, collagen peptide, vitamin C, gamma-aminobutyric acid, a flavor substance, pectin, sodium hyaluronate, sodium citrate, citric acid and mogroside. The aloe and gastrodia elata mask has the advantages that the aloe and gastrodia elata mask has the functions of helping sleep, whitening, resisting oxidation, resisting wrinkles and tightening, the specific taste of aloe and gastrodia elata is reserved, and the quality is stable and controllable.

Description

Technical Field

[0001] The invention belongs to the technical field of biomedicine, and in particular relates to a gastrodia elata and aloe oral liquid and a preparation method thereof. Background Art

[0002] Under the high-pressure environment of modern society, collagen loss, dull complexion, and fragile facial barrier have become common skin problems, and poor sleep quality is one of the important factors leading to these problems. In addition to taking conventional sleep aids and smear-type cosmetics, oral beauty has emerged in this environment. More and more consumers expect to improve their skin condition from the inside out through endogenous supplements.

[0003] In recent years, the scale of oral beauty has grown rapidly, showing a trend of becoming younger, more snack-like, and with gradually subdivided functions. Domestic brands have developed rapidly and occupied a place in the oral beauty market, but there are serious problems of homogeneity in the functions and ingredients of the products. For example, the functions of oral beauty products are mainly concentrated in whitening, moisturizing, etc., while ingredients such as collagen peptides, sodium hyaluronate, vitamin C and grape seeds are commonly used raw materials in oral hair beauty products.

[0004] With the improvement of people's living standards and the enhancement of health awareness, food, medicine, health products and cosmetics are increasingly tending to be green, natural and pollution-free. The trend of plant extract ingredients with "natural" properties is gradually becoming popular in oral beauty products. According to statistics, in 2021, the sales of oral beauty products with added plant ingredients increased by more than 70% year-on-year, far exceeding the sales of oral beauty products in the same year, with a sales growth rate of 29%. It can be seen that the addition of natural plant ingredients is an inevitable trend in the development of oral beauty products. However, there is currently no oral beauty product on the market that uses natural plant ingredients as the main added ingredient. Yunnan has rich plant resources, and more and more plant raw materials are approved for use in ordinary foods, which brings new opportunities for oral beauty products. Summary of the invention

[0005] The invention aims to provide a gastrodia elata and aloe oral liquid prepared from natural plant ingredients.

[0006] To achieve the above object, the technical solution adopted by the present invention is:

[0007] A gastrodia aloe oral liquid comprises the following components: aloe vera gel juice, gastrodia extract, fruit juice, erythritol, collagen peptide, vitamin C, gamma-aminobutyric acid, flavoring substances, pectin, sodium hyaluronate, sodium citrate, citric acid and mogroside.

[0008] Gastrodia elata is a plant of the genus Gastrodia in the orchid family, also known as magic grass, red arrow, white dragon skin, mountain potato, etc. It is widely planted in Jilin, Hebei, Gansu, Jiangsu, Jiangxi, Sichuan, Guizhou, Yunnan, Tibet and other places in my country. Among them, the Gastrodia elata in Zhaotong City, Yunnan Province has the highest quality, the highest content of gastrodin, and is the most famous. It is a specialty of Zhaotong City, Yunnan Province and a national geographical indication product. Gastrodia elata has always been used as a traditional Chinese medicinal material. On November 17, 2023, it was included in the announcement list of both food and medicine, providing a compliance basis for its use in ordinary foods. Gastrodia elata has pharmacological effects such as treating numbness of the limbs, rheumatic pain, dizziness, headache, sedation and sleep aid, providing a new direction for oral beauty products to help sleep and beauty.

[0009] As a natural plant raw material, the Ministry of Health approved aloe vera gel as a new food raw material in 2008, and it has been widely used in ordinary foods. According to various data studies, edible aloe vera has multiple health functions such as anti-oxidation, beauty and skin care, and promoting the synthesis of endogenous collagen and hyaluronic acid.

[0010] By compounding collagen peptides, sodium hyaluronate, vitamin C, the sleep-aiding ingredient γ-aminobutyric acid, etc. with Yunnan's characteristic plant raw materials - Gastrodia elata and aloe vera, it has the functions of effectively aiding sleep, whitening, anti-oxidation, anti-wrinkle and firming.

[0011] Preferably, the Gastrodia elata aloe oral liquid is made of the following components in parts by weight: 50-85 parts of aloe vera gel juice, 5-10 parts of Gastrodia elata extract, 5-10 parts of fruit juice, 5-10 parts of erythritol, 3-10 parts of collagen peptides, 0.2-2 parts of vitamin C, 0.05-0.35 parts of γ-aminobutyric acid, 0.05-0.3 parts of flavor substances, 0.05-0.3 parts of pectin, 0.02-0.2 parts of sodium hyaluronate, 0.02-0.2 parts of sodium citrate, 0.02-0.2 parts of citric acid and 0.01-0.05 parts of mogroside.

[0012] Preferably, the Gastrodia elata aloe oral liquid is made of the following components in parts by weight: 60-75 parts of aloe vera gel juice, 7-9 parts of Gastrodia elata extract, 7-9 parts of fruit juice, 7-9 parts of erythritol, 5-8 parts of collagen peptides, 0.5-1.5 parts of vitamin C, 0.1-0.3 parts of γ-aminobutyric acid, 0.1-0.2 parts of flavor substances, 0.1-0.2 parts of pectin, 0.05-0.15 parts of sodium hyaluronate, 0.05-0.15 parts of sodium citrate, 0.05-0.1 parts of citric acid and 0.02-0.03 parts of mogroside.

[0013] Preferably, the Gastrodia elata aloe oral liquid is made of the following components in parts by weight: 70 parts of aloe vera gel juice, 8 parts of Gastrodia elata extract, 8 parts of fruit juice, 8 parts of erythritol, 6 parts of collagen peptides, 1 part of vitamin C, 0.2 parts of γ-aminobutyric acid, 0.15 parts of flavor substances, 0.15 parts of pectin, 0.1 parts of sodium hyaluronate, 0.1 parts of sodium citrate, 0.08 parts of citric acid and 0.02 parts of mogroside.

[0014] Preferably, the juice is selected from one of blueberry juice, elderberry concentrate, peach concentrate, jasmine concentrate or passion fruit concentrate.

[0015] Preferably, the flavoring substance is selected from raspberry.

[0016] The present invention also provides a method for preparing the Tianma aloe oral liquid, comprising the following steps:

[0017] (1) Mixing: Weigh erythritol, collagen peptide, vitamin C, γ-aminobutyric acid, pectin, sodium hyaluronate, sodium citrate, citric acid, and mogroside according to weight, dry mix evenly, add aloe vera gel juice, stir to dissolve, then add gastrodia elata extract, juice, and flavor substances and continue to mix evenly to obtain a mixed material;

[0018] (2) packaging: packaging the mixed material to obtain an oral solution;

[0019] (3) Sterilization: Place the packaged oral liquid in a water bath at 82°C to 88°C for 30 minutes, and then quickly cool it in cold water to obtain the oral liquid.

[0020] Beneficial effects of the present invention:

[0021] (1) The present invention adopts the natural plant ingredients of aloe vera gel juice and gastrodia elata extract as the main raw materials, and then adds fruit juice, erythritol, collagen peptide, vitamin C, γ-aminobutyric acid, flavor substances, pectin, sodium hyaluronate, sodium citrate, citric acid and mogroside, which work together to have the functions of helping sleep, whitening, anti-oxidation, anti-wrinkle and firming.

[0022] (2) The present invention uses a large dose of aloe vera gel juice instead of traditional water as a raw material for preparing the oral solution. Studies have shown that the aloe vera gel juice does not react with other ingredients in the product and does not affect the stability of the oral solution.

[0023] (3) The oral liquid of the present invention retains the unique taste of aloe vera and gastrodia elata, and the quality is stable and controllable. DETAILED DESCRIPTION

[0024] In order to enable those skilled in the art to understand the production process and technical effects of the present invention in detail, the application and technical effects of the present invention are further introduced with specific production examples below.

[0025] Example 1

[0026] A method for preparing gastrodia elata and aloe oral liquid comprises the following steps:

[0027] According to weight, weigh 70 parts of aloe vera gel juice, 8 parts of Gastrodia elata extract, 8 parts of blueberry juice, 8 parts of erythritol, 6 parts of collagen peptides, 1 part of vitamin C, 0.2 parts of γ-aminobutyric acid, 0.15 parts of raspberries, 0.15 parts of pectin, 0.1 parts of sodium hyaluronate, 0.1 parts of sodium citrate, 0.08 parts of citric acid and 0.02 parts of mogroside.

[0028] (1) Mixing: dry-mix erythritol, collagen peptide, vitamin C, γ-aminobutyric acid, pectin, sodium hyaluronate, sodium citrate, citric acid, and mogroside, add aloe vera gel juice, stir to dissolve, then add gastrodia extract, blueberry juice, and raspberry and continue to mix to obtain a mixed material;

[0029] (2) packaging: packaging the mixed material to obtain an oral solution;

[0030] (3) Sterilization: Place the packaged oral liquid in a water bath at 82°C to 88°C for 30 minutes, and then quickly cool it in cold water to obtain the oral liquid.

[0031] Example 2

[0032] A method for preparing gastrodia elata and aloe oral liquid comprises the following steps:

[0033] According to weight, weigh 75 parts of aloe vera gel juice, 9 parts of Gastrodia elata extract, 9 parts of elderberry concentrate, 9 parts of erythritol, 8 parts of collagen peptides, 1.5 parts of vitamin C, 0.3 parts of γ-aminobutyric acid, 0.2 parts of raspberries, 0.2 parts of pectin, 0.15 parts of sodium hyaluronate, 0.15 parts of sodium citrate, 0.1 parts of citric acid and 0.03 parts of mogroside.

[0034] (1) Mixing: dry-mix erythritol, collagen peptide, vitamin C, γ-aminobutyric acid, pectin, sodium hyaluronate, sodium citrate, citric acid, and mogroside, add aloe vera gel juice, stir to dissolve, then add gastrodia elata extract, elderberry concentrate, and raspberry and continue to mix to obtain a mixed material;

[0035] (2) packaging: packaging the mixed material to obtain an oral solution;

[0036] (3) Sterilization: Place the packaged oral liquid in a water bath at 82°C to 88°C for 30 minutes, and then quickly cool it in cold water to obtain the oral liquid.

[0037] Example 3

[0038] A method for preparing gastrodia elata and aloe oral liquid comprises the following steps:

[0039] By weight, weigh 60 parts of aloe vera gel juice, 7 parts of Gastrodia elata extract, 7 parts of peach concentrated juice, 7 parts of erythritol, 5 parts of collagen peptides, 0.5 parts of vitamin C, 0.1 parts of γ-aminobutyric acid, 0.1 parts of raspberries, 0.1 parts of pectin, 0.05 parts of sodium hyaluronate, 0.05 parts of sodium citrate, 0.05 parts of citric acid and 0.02 parts of mogroside.

[0040] (1) Mixing: dry-mix erythritol, collagen peptide, vitamin C, γ-aminobutyric acid, pectin, sodium hyaluronate, sodium citrate, citric acid, and mogroside, add aloe vera gel juice, stir to dissolve, then add gastrodia elata extract, peach concentrate juice, and raspberry and continue to mix to obtain a mixed material;

[0041] (2) packaging: packaging the mixed material to obtain an oral solution;

[0042] (3) Sterilization: Place the packaged oral liquid in a water bath at 82°C to 88°C for 30 minutes, and then quickly cool it in cold water to obtain the oral liquid.

[0043] Example 4

[0044] A method for preparing gastrodia elata and aloe oral liquid comprises the following steps:

[0045] According to weight, weigh 85 parts of aloe vera gel juice, 10 parts of Gastrodia elata extract, 10 parts of jasmine concentrate, 10 parts of erythritol, 10 parts of collagen peptides, 2 parts of vitamin C, 0.35 parts of γ-aminobutyric acid, 0.3 parts of raspberries, 0.3 parts of pectin, 0.2 parts of sodium hyaluronate, 0.2 parts of sodium citrate, 0.2 parts of citric acid and 0.05 parts of mogroside.

[0046] (1) Mixing: dry-mix erythritol, collagen peptide, vitamin C, γ-aminobutyric acid, pectin, sodium hyaluronate, sodium citrate, citric acid, and mogroside, add aloe vera gel juice, stir to dissolve, then add gastrodia elata extract, jasmine concentrate, and raspberry and continue to mix to obtain a mixed material;

[0047] (2) packaging: packaging the mixed material to obtain an oral solution;

[0048] (3) Sterilization: Place the packaged oral liquid in a water bath at 82°C to 88°C for 30 minutes, and then quickly cool it in cold water to obtain the oral liquid.

[0049] Example 5

[0050] A method for preparing gastrodia elata and aloe oral liquid comprises the following steps:

[0051] By weight, weigh 50 parts of aloe vera gel juice, 5 parts of Gastrodia elata extract, 5 parts of passion fruit concentrate, 5 parts of erythritol, 3 parts of collagen peptides, 0.2 parts of vitamin C, 0.05 parts of γ-aminobutyric acid, 0.05 parts of raspberries, 0.05 parts of pectin, 0.02 parts of sodium hyaluronate, 0.02 parts of sodium citrate, 0.02 parts of citric acid and 0.01 parts of mogroside.

[0052] (1) Mixing: dry-mix erythritol, collagen peptide, vitamin C, γ-aminobutyric acid, pectin, sodium hyaluronate, sodium citrate, citric acid, and mogroside, add aloe vera gel juice, stir to dissolve, then add gastrodia elata extract, passion fruit concentrate, and raspberry and continue to mix to obtain a mixed material;

[0053] (2) packaging: packaging the mixed material to obtain an oral solution;

[0054] (3) Sterilization: Place the packaged oral liquid in a water bath at 82°C to 88°C for 30 minutes, and then quickly cool it in cold water to obtain the oral liquid.

[0055] In the above embodiments, the raw materials used are all commercially available products.

[0056] In order to better verify the effect of the present invention, the following test is performed:

[0057] DPPH free radical scavenging and tyrosinase activity inhibition assays

[0058] 1. Experimental Reagents

[0059] DPPH, water-soluble vitamin E (Trolox), mushroom tyrosinase, L-dopa (L-Dopa) and kojic acid (KojicAcid) were purchased from Sigma.

[0060] 2. Experimental Methods

[0061] 1. DPPH free radical scavenging experiment

[0062] The drug to be tested was mixed with DPPH (final concentration of 100 μM) for reaction, and three replicate wells were set. At the same time, blank control wells without drug and Trolox positive control wells were set. The OD value was measured by microplate reader at 30°C for 1 h. The detection wavelength was 515 nm, and the DPPH free radical scavenging rate was calculated.

[0063] DPPH free radical scavenging rate (%) = (1-sample well OD 515 nm / OD of experimental control well 515 nm )×100%

[0064] 2. Tyrosinase activity inhibition experiment

[0065] The drug to be tested was mixed with L-Dopa, and tyrosinase (final concentration 25 U / mL) was added to start the reaction. Three replicate wells were set, and a blank control without drug and a 377 positive control were set at the same time. The OD value was measured by a microplate reader at room temperature for 5 minutes, and the detection wavelength was 490 nm. The tyrosinase activity inhibition rate was calculated.

[0066] Tyrosinase activity inhibition rate (%) = (1-sample well OD 490 nm / OD of experimental control well 490 nm )×100

[0067] 3. Experimental Results

[0068] Table 1 Scavenging effect of samples on DPPH free radicals

[0069] sample concentration DPPH free radical scavenging rate (%) Trolox 25 μg / mL 94.737±0 Collagen peptide vitamin C drink 0.1％ 90.226±0.846 Feichang Magnetic Collagen Peptide Fruit Drink (Raspberry Flavor) 0.1％ 1.034±0.431 The Collagen collagen peptide oral solution 0.1％ 95.019±0.326 Example 1 Product 0.1％ 96.147±1.14

[0070] Table 2 Inhibition of samples on tyrosinase

[0071] sample concentration Tyrosinase inhibition rate (%) 377 0.5μM 71.787±0.251 Collagen peptide vitamin C drink 2％ 88.481±1.063 Feichang Magnetic Collagen Peptide Fruit Drink (Raspberry Flavor) 2％ 10.894±0.532 The Collagen collagen peptide oral solution 2％ 69.533±1.417 Example 1 Product 2％ 99.082±0.383

[0072] IV. Conclusion

[0073] This experiment evaluated the DPPH free radical scavenging ability and tyrosinase inhibition ability of four samples.

[0074] As shown in Table 1, the results of the DPPH free radical scavenging experiment show that when the concentration is 0.1%, the product of the present invention has a strong scavenging effect on DPPH free radicals and has an antioxidant function. As shown in Table 2, the results of the tyrosinase activity inhibition experiment show that when the concentration is 2%, the product of the present invention has a strong inhibitory effect on tyrosinase activity and has a whitening function.

[0075] Finally, it should be noted that the above embodiments are only used to illustrate rather than limit the technical solutions of the present invention. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art should understand that the present invention can still be modified or replaced by equivalents. Any modification or partial replacement that does not depart from the spirit and scope of the present invention should be included in the scope of the claims of the present invention.

Claims

1. A gastrodia elata and aloe oral liquid, characterized in that: The invention comprises the following components: aloe vera gel juice, gastrodia elata extract, juice, erythritol, collagen peptide, vitamin C, gamma-aminobutyric acid, flavoring substances, pectin, sodium hyaluronate, sodium citrate, citric acid and mogroside.

2. The Gastrodia elata and aloe oral liquid according to claim 1, characterized in that: The invention is prepared from the following components in parts by weight: 50-85 parts of aloe vera gel juice, 5-10 parts of gastrodia elata extract, 5-10 parts of fruit juice, 5-10 parts of erythritol, 3-10 parts of collagen peptides, 0.2-2 parts of vitamin C, 0.05-0.35 parts of gamma-aminobutyric acid, 0.05-0.3 parts of flavor substances, 0.05-0.3 parts of pectin, 0.02-0.2 parts of sodium hyaluronate, 0.02-0.2 parts of sodium citrate, 0.02-0.2 parts of citric acid and 0.01-0.05 parts of mogroside.

3. The Gastrodia elata and aloe oral liquid according to claim 2, characterized in that: The invention is prepared from the following components in parts by weight: 60-75 parts of aloe vera gel juice, 7-9 parts of gastrodia elata extract, 7-9 parts of fruit juice, 7-9 parts of erythritol, 5-8 parts of collagen peptide, 0.5-1.5 parts of vitamin C, 0.1-0.3 parts of gamma-aminobutyric acid, 0.1-0.2 parts of flavor substances, 0.1-0.2 parts of pectin, 0.05-0.15 parts of sodium hyaluronate, 0.05-0.15 parts of sodium citrate, 0.05-0.1 parts of citric acid and 0.02-0.03 parts of mogroside.

4. The Tianma aloe oral liquid according to claim 3, characterized in that: The invention is prepared from the following components in parts by weight: 70 parts of aloe vera gel juice, 8 parts of gastrodia elata extract, 8 parts of fruit juice, 8 parts of erythritol, 6 parts of collagen peptides, 1 part of vitamin C, 0.2 parts of gamma-aminobutyric acid, 0.15 parts of flavor substances, 0.15 parts of pectin, 0.1 parts of sodium hyaluronate, 0.1 parts of sodium citrate, 0.08 parts of citric acid and 0.02 parts of mogroside.

5. The Tianma aloe oral liquid according to claim 1, characterized in that: The fruit juice is selected from one of blueberry juice, elderberry concentrate, peach concentrate, jasmine concentrate or passion fruit concentrate.

6. The Tianma aloe oral liquid according to claim 1, characterized in that: The flavoring substance is selected from raspberry.

7. A method for preparing the Tianma Aloe oral liquid according to any one of claims 1 to 5, characterized in that: The following steps are involved: (1) Mixing: Weigh erythritol, collagen peptide, vitamin C, γ-aminobutyric acid, pectin, sodium hyaluronate, sodium citrate, citric acid, and mogroside according to weight, dry mix evenly, add aloe vera gel juice, stir to dissolve, then add gastrodia elata extract, juice, and flavor substances and continue to mix evenly to obtain a mixed material; (2) packaging: packaging the mixed material to obtain an oral solution; (3) Sterilization: Place the packaged oral liquid in a water bath at 82°C to 88°C for 30 minutes, and then quickly cool it in cold water to obtain the oral liquid.