Tumor Electric Field Therapy System and Electrode Patch

Abstract

The present application provides a tumor electrotherapy system and an electrode patch. The electrode patch includes an electrode array and a plurality of adhesive members. The electrode array includes a plurality of electrode units through which an alternating current signal passes and a plurality of connecting portions located between the plurality of electrode units and connecting adjacent two electrode units. Each electrode unit includes a main body portion, a conductive sheet provided on the main body portion, and a dielectric layer covering the conductive sheet and electrically connected to the conductive sheet. Adjacent two electrode units and the connecting portion electrically connecting the two electrode units form an electrode unit group, and a plurality of adhesive members cover the corresponding electrode unit groups. When an alternating current signal is applied to the electrode array, the current flowing through each electrode unit has a uniform current density. For the tumor electrotherapy system and the electrode patch of the present application, by utilizing the influence of the dielectric layer thickness on the current density, dielectric layers with different thicknesses are provided for the electrode unit groups or electrode units at different positions of the electrode patch, so that the current densities of the respective electrode units are more consistent, and the problem of edge effect is alleviated.

Description

Technical Field

[0001] The present application relates to a tumor electric field treatment system and an electrode patch for tumor treatment. Background Art

[0002] Medium-frequency alternating electric field treatment has been proven to be an effective method for tumor treatment. It can interfere with the mitosis process of cancer cells and induce apoptosis of cancer cells, and can be used to treat tumors. A tumor electric field treatment system generally includes an electric field generator, an adapter, and multiple pairs of electrode patches. The electric field generator generates an alternating electric signal, and the alternating electric signal is transmitted to the electrode patches through the adapter. The electrode patches are applied in pairs on the body surfaces on the opposite sides of the tumor site of the patient, and an alternating current signal is applied between each pair of electrode patches to non-invasively apply a tumor treatment electric field to the tumor site.

[0003] The effect of electric field treatment on cancer cells varies according to the intensity of the electric field applied to the tumor tissue. Specifically, the greater the intensity of the electric field, the better the effect of inhibiting the death and division of cancer cells. However, the prior art has found that among several electrode units of the electrode patch, compared with the electrode units located at the center position of the electrode patch, the electrode units located at the edge position of the electrode patch have lower impedance to the current flowing through them, resulting in higher current density in the electrode units located at the edge position of the electrode patch. In addition, the electrode units located at the edge corners or similar sharp bends of the electrode patch also have higher current density than other electrode units located at the edge of the electrode patch. The current density here refers to the volume current density. According to Lenz's law, the heat Q of each electrode unit can be obtained as Q = I 2 Rt, where I represents the current intensity, R represents the resistance of the object itself, t represents the time, and Q represents the heat generated when the current passes through. It can be seen that the heat is proportional to the current intensity. In electromagnetic field theory, the relationship between the current density J and the current intensity I is: I = ∫JdS, which indicates that the current intensity of the surface S is equal to the flux of the current density passing through the surface, that is, the magnitude of the volume current density is proportional to the heat generated by the object, that is, the greater the current density at a certain place of the object, the more heat is generated at that place. And in the electrode patch, the phenomenon that a relatively large amount of current passes through the electrode units located at its edge, especially the electrode units located at its edge corners, is the edge effect. The edge effect will cause the corresponding electrode units to generate a large amount of heat and have a rapid temperature rise. Generally, after the temperature of the electrode unit rises, the tumor electric field treatment system will reduce the intensity of the alternating electric signal applied to the electrode patch by the electric field generator to ensure the safety of the human body and avoid low-temperature scalding.

[0004] The edge effect caused by the uneven current distribution of each electrode unit on the electrode patch will cause the temperature of the electrode units at the edge of the electrode patch, especially at the corners, to rise relatively fast. These electrode units will reach the set safety threshold temperature first, which will cause the tumor electric field therapy system to reduce the current to avoid causing low-temperature burns to the patient. Therefore, the maximum working current of the electrode patch is limited, the intensity of tumor electric field therapy is reduced, and the tumor treatment effect is affected.

[0005] Therefore, it is necessary to improve the existing tumor electric field therapy system and electrode patch. Summary of the Invention

[0006] This application provides a tumor electric field therapy system and an electrode patch, which can alleviate the influence of the edge effect.

[0007] Specifically, this application is implemented through the following technical solutions: An electrode patch includes an electrode array and a plurality of adhesive parts. The electrode array includes a plurality of electrode units through which an alternating current signal passes and a plurality of connecting parts located between the plurality of electrode units and connecting adjacent two electrode units. Each electrode unit includes a main body part, a conductive sheet provided on the main body part, and a dielectric layer covering the conductive sheet and electrically connected to the conductive sheet. Two adjacent electrode units and the connecting part electrically connecting the two electrode units form an electrode unit group. A plurality of adhesive parts cover the corresponding electrode unit groups. When an alternating current signal is applied to the electrode array, the current flowing through each electrode unit has a balanced current density.

[0008] According to an embodiment of the present invention, the thickness of the dielectric layer of the electrode units in a plurality of the electrode unit groups located on the periphery of the electrode array is greater than the thickness of the dielectric layer of the electrode units in a plurality of the electrode unit groups located at the center of the electrode array.

[0009] According to an embodiment of the present invention, the thickness of the dielectric layer of the electrode units in a plurality of the electrode unit groups located at the corners of the periphery of the electrode array is greater than the thickness of the dielectric layer of the electrode units in a plurality of the other electrode unit groups located on the periphery of the electrode array.

[0010] According to an embodiment of the present invention, the thickness ratio of the dielectric layers of the electrode units in the electrode unit groups located at the center of the electrode array, on the periphery of the electrode array but not at the corners, and at the corners of the periphery of the electrode array is 1:2:3 or 1:1:3 or 5:7:10;

[0011] According to an embodiment of the present invention, the ratio range of the thickness of the dielectric layer in each of the electrode unit groups located at the center of the electrode array to the thickness of the dielectric layer in each of the electrode unit groups located at the corners of the periphery of the electrode array is from 1:3 to 1:2.

[0012] According to an embodiment of the present invention, the thickness of the dielectric layer of the electrode unit located at the center of the electrode array is 0.005 mm; the thickness of the dielectric layer of each electrode unit located at the outer corner of the electrode array is 0.01 mm to 0.015 mm.

[0013] According to an embodiment of the present invention, the thickness of the dielectric layer of the electrode unit located at the periphery of the electrode array but not at the corner is 0.005 mm to 0.10 mm.

[0014] According to an embodiment of the present invention, the dielectric layers of the two electrode units within the same electrode unit group also cover and are continuously arranged on the connection part between the two electrode units and have the same thickness, and each electrode unit group has the same structure and size except for the different dielectric layer thicknesses.

[0015] According to an embodiment of the present invention, the adhesive is a hydrogel, and the adhesive has an extension size that extends beyond the corresponding edge of the main body part unilaterally, and the extension size ranges from 0 mm to 3 mm.

[0016] This application is also achieved by the following technical solutions: An electrode patch includes an electrode array and a plurality of adhesives. The electrode array includes a plurality of electrode units and a plurality of connection parts located between the plurality of electrode units and connecting adjacent two electrode units. The plurality of adhesives respectively cover the corresponding electrode units one by one. The electrode unit includes a main body part, a conductive sheet arranged on the main body part, and a dielectric layer covering the conductive sheet and electrically connected to the conductive sheet. When an alternating current signal is applied to the electrode array, the current flowing through each electrode unit has a balanced current density.

[0017] According to an embodiment of the present invention, the thickness of the dielectric layer of a plurality of electrode units located at the periphery of the electrode array is greater than the thickness of the dielectric layer of a plurality of electrode units located at the center of the electrode array.

[0018] According to an embodiment of the present invention, the thickness of the dielectric layer of a plurality of electrode units located at the outer corner of the electrode array is greater than the thickness of the dielectric layer of a plurality of other electrode units located at the periphery of the electrode array but not at the corner.

[0019] This application also provides the following technical solutions: A tumor electric field treatment system includes an electric field generator, an adapter, and a plurality of pairs of the foregoing electrode patches. The adapter is electrically connected to the electric field generator and each electrode patch.

[0020] The tumor electro-field therapy system and electrode patch of the present application utilize the influence of the dielectric layer thickness on the current density. By setting dielectric layers with different thicknesses for electrode unit groups or electrode units at different positions on the electrode patch, the current density of each electrode unit can be made more uniform, alleviating the problem of edge effect.

[0021] It should be understood that the above general description and the following detailed description are only exemplary and explanatory, and cannot limit the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 System block diagram of a tumor electro-field therapy system according to an embodiment of the present application;

[0023] Figure 2 Plan view of an electrode patch according to an embodiment of the present application;

[0024] Figure 3 is Figure 2 Plan view of the electrode array of the shown electrode patch;

[0025] Figure 4 Shows a plan view of a single electrode unit group C in the electrode array, where the insulating cover film and the dielectric layer have not been laid yet;

[0026] Figure 5 Similar to Figure 4 except that the insulating cover film is further laid;

[0027] Figure 6 Schematic diagram of the basic modeling model of the electrode patch;

[0028] Figure 7 is Figure 2 Cross-sectional view at the edge of a single electrode unit in

[0029] Figure 8 Schematic diagram of the current density distribution of the electrode patch in Comparative Example 1;

[0030] Figure 9 Schematic diagram of the current density distribution of the electrode patch in Comparative Example 3;

[0031] Figure 10 Graph of the current density peak data of each electrode unit in Comparative Examples 1 to 3;

[0032] Figure 11 Graph for comparing the uniformity of the current density peaks of each electrode unit in Comparative Examples 1 to 3;

[0033] Figure 12 Schematic diagram of the current density distribution of the electrode patch in Comparative Example 4;

[0034] Figure 13 Schematic diagram of current density distribution of the electrode patch in Comparative Example 5;

[0035] Figure 14 Schematic diagram of current density distribution of the electrode patch in Comparative Example 6;

[0036] Figure 15 Graph of the peak values of the maximum current density of each electrode unit in Comparative Examples 3 to 6;

[0037] Figure 16 Comparison diagram of the uniformity of the current density peak values of each electrode unit in Comparative Examples 3 to 6;

[0038] Figure 17 is Figure 3 Plan view of a single electrode unit group C of the electrode array shown;

[0039] Figure 18 is Figure 3 Distribution diagram of the electrode unit group C of the electrode array shown.

[0040] Explanation of reference numerals:

[0041] Tumor electric field therapy system 100, electric field generator 10, adapter 20, electrode patch 30, backing 31, electrode array 32, electrode unit 320, connecting portion 321, boundary line 3211, wiring portion 322, gold finger 3221, temperature sensor 323, substrate 325, main body portion 3250, connecting strip 3251, conductive sheet 326, pad 327, insulating cover film 328, dielectric layer 329, adhesive member 33. Detailed implementation manners

[0042] Here, the exemplary embodiments will be described in detail, and the examples are shown in the drawings. When the following description refers to the drawings, unless otherwise indicated, the same numbers in different drawings represent the same or similar elements. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with the present application. On the contrary, they are merely examples of devices, systems, devices, and methods consistent with some aspects of the present application.

[0043] Referring to Figure 1 shown, the tumor electric field therapy system 100 includes an electric field generator 10, an adapter 20, and a plurality of pairs of electrode patches 30. The adapter 20 is electrically connected to the electric field generator 10 and each electrode patch 30. The electric field generator 10 generates an alternating current signal required for tumor treatment. The adapter 20 receives the alternating current signal output from the electric field generator 10 and transmits the alternating current signal to the electrode patch 30. The electrode patch 30 is attached to the body surface of the patient corresponding to the tumor area, and the alternating current signal is applied to the tumor area of the patient for tumor electric field therapy.

[0044] Reference Figure 2 and Figure 3 As shown, the electrode patch 30 includes a backing 31, an electrode array 32 and an adhesive 33. The side of the electrode patch 30 facing the patient's skin is defined as the front side. The electrode array 32 is attached to the front side of the backing 31, and the adhesive 33 is attached to the front side of the electrode array 32. The electrode array 32 includes twenty electrode units 320 arranged at intervals, a plurality of connecting portions 321 connecting adjacent two electrode units 320, and a wiring portion 322 connected to the adapter 20 through a wire (not shown). The electrode array 32 applies an alternating current signal to the tumor area of the patient through the electrode units 320.

[0045] The twenty electrode units 320 are generally arranged in an array of four rows and six columns. Each of the first row and the fourth row is provided with four electrode units 320, and each of the second row and the third row is provided with six electrode units 320. The six electrode units 320 in each of the second row and the third row are respectively in one-to-one correspondence up and down and are generally arranged in six columns. The four electrode units 320 in each of the first row and the fourth row are respectively located in the middle four columns. Two adjacent electrode units 320 in each row form an electrode unit group C. These twenty electrode units 320 form 10 electrode unit groups C from left to right and from top to bottom. Among them, in the ten electrode unit groups C, the electrode unit groups C1, C2, C9, and C10 are respectively located at the four corners of the periphery of the electrode patch 30; the four electrode unit groups C3, C5, C6, and C8 are located at the periphery of the electrode patch 30 but not at the corners; the remaining two electrode unit groups C4 and C7 are located at the center of the electrode patch 30. Some of the electrode units 320 are provided with temperature sensors 323 for measuring temperature. Among them, at most one temperature sensor 323 is provided on only one of the electrode units 320 in each electrode unit group C. The multiple electrode units 320 located on the same row are not distributed in a straight line shape, but are generally distributed in an arc shape. Among them, the electrode units 320 in each of the first row and the second row are all distributed on the arcs with both ends upturned, and the electrode units 320 in each of the third row and the fourth row are all distributed on the arcs with both ends downturned. With this shape design, the electrode array 32 is more suitable for being attached to the waist, which can improve the attachability of the electrode patch 30 and avoid wrinkling during attachment.

[0046] A plurality of adhesives 33 cover each electrode unit 320 and are directly attached to the corresponding body surface of the patient's tumor as an attachment surface. Preferably, a conductive hydrogel is used, which can enhance the attachment comfort between the electrode unit 320 and the patient's body surface, and at the same time can also serve as a conductive medium for the alternating current signal passing through the electrode unit 320 to pass through and be applied to the patient's tumor site. In this embodiment, there are ten adhesives 33, which are adhered corresponding to each electrode unit group C. The shape of the adhesive 33 is generally the same as that of the electrode unit group C, and its size is slightly larger than that of the electrode unit group C and is generally arranged in a dumbbell shape. The thickness of the adhesive 33 is 0.1 mm - 1 mm.

[0047] The hierarchical structure of the electrode array 32 will be described below. Refer to Figure 3 As shown, the electrode array 32 includes a flexible substrate 325 arranged in a sheet shape. The substrate 325 serves as a supporting base plate and is integrally disposed in each electrode unit 320, each connecting portion 321, and the wiring portion 322. For the convenience of description, the portion of the substrate 325 corresponding to each electrode unit 320 is defined as the main body portion 3250, and the portion of the substrate 325 corresponding to each connecting portion 321 and the wiring portion 322 is defined as the connecting strip 3251. Each main body portion 3250 and each connecting strip 3251 are different parts of the entire substrate 325. The thickness of the substrate 325 is 0.1 mm - 0.3 mm, and the preferred material is polyimide, which has the characteristics of light weight, thin thickness, bendability, and high deflection. The main body portion 3250 is circular, and the electrode unit 320 is provided with a conductive sheet 326 on the main body portion 3250. The conductive sheet 326 is annular, with a thickness of 10 μm to 50 μm, and its outer diameter is smaller than the diameter of the main body portion 3250. A pair of pads 327 for electrically connecting to the temperature sensor 323 are provided on a part of the main body portion 3250, and the thickness of the pads 327 is also 10 μm to 50 μm. A plurality of conductive traces (not shown) are arranged on the substrate 325 of the electrode array 32. The wiring portion 322 is provided with a plurality of gold fingers 3221. One of the conductive traces (not shown) for transmitting an alternating current signal extends from a corresponding gold finger 3221 to the conductive sheet 326 of each main body portion 3250, and the other conductive traces (not shown) for obtaining the temperature measurement signal of the temperature sensor 323 extend from the corresponding gold fingers 3221 to the pads 327 of the corresponding main body portions 3250.

[0048] Refer to Figure 5 As shown, an insulating cover film 328 is integrally laid on the front surface of the substrate 325 of the electrode array 32. The thickness of the insulating cover film 328 is 10 μm to 50 μm, and the preferred material is polyimide. Please note that each insulating cover film 328 can cover each conductive trace (not shown), but the conductive sheet 326, the pads 327, and the gold fingers 3221 need to be exposed. The insulating cover film 328 on the main body portion 3250 is in a hub shape and serves to insulate heat and prevent soldering. Return to Figure 4As shown, the electrode array 32 further includes a dielectric layer 329. The dielectric layer 329 integrally covers the insulating cover film 328 of each electrode unit group C and the conductive sheet 326 not covered with the insulating cover film 328 for each electrode unit group C. That is, the dielectric layers 329 of the two electrode units 320 within the same electrode unit group C are continuously arranged, and the dielectric layers 329 between each electrode unit group C are discontinuously arranged. That is, the dielectric layer 329 is divided into multiple regions arranged at intervals. The dielectric layer 329 is electrically connected to the conductive sheet 326 and completely covers the conductive sheet 326 to prevent the direct contact between the conductive sheet 326 and the human body from generating direct current conduction and affecting human safety. The dielectric layer 329 is a polymer dielectric layer with a high dielectric constant and a low dielectric loss, and it is made of a thin film material with a non-fixed crystal orientation, a high deflection, and a high toughness. The thickness of the dielectric layer 329 is 5μm - 1000μm.

[0049] Combined with Figure 7 As shown, the electrode unit 320 includes, from bottom to top, a substrate 325 with a thickness of 0.1mm - 0.3mm, a conductive sheet 326 and a pad 327 with a thickness of 10μm - 50μm each, an insulating cover film 328 with a thickness of 10μm - 50μm, and a dielectric layer 329 with a thickness of 5μm - 1000μm. In addition, the thickness of the adhesive 33 covering the electrode unit group C is 0.1mm - 1mm, and the contour edge of the adhesive 33 is greater than or equal to the outer edge contour of the electrode unit group C. That is, the contour of the adhesive 33 is greater than or equal to the contour edge of the corresponding part of the substrate 325. The size of the adhesive 33 extending beyond the outer edge contour of the corresponding electrode unit group C on one side is defined as the extension size. The increase in the extension size of the adhesive 33, or the increase in the coverage area of the adhesive 33, can reduce the peak value of the current density flowing through the corresponding electrode unit 320, alleviate the edge effect problem of the electrode patch 30, and at the same time improve the current density uniformity (balance) of each electrode unit 320 on the electrode patch 30, make the thermal effect of the corresponding electrode patch 30 more uniform, contribute to improving the uniformity of the effective treatment electric field intensity in the target area, and reduce the requirements for the application position. The extension size of the adhesive 33 is 0mm - 3mm. Preferably, the extension size of the adhesive 33 is 3mm.

[0050] Refer to Figure 17As shown, the structure of each electrode unit group C is the same, and it is arranged in a dumbbell shape. The electrode unit group C is provided with a horizontal axis X1 and a vertical axis Y1, and the electrode unit group C is symmetrically arranged along the horizontal axis X1 and the vertical axis Y1 respectively. The center distance between the two electrode units 320 in a single electrode unit group C is 32 - 35 mm, preferably 33.5 mm, and the radius of a single electrode unit 320 is 9 - 11 mm, preferably 11 mm; the boundary line 3211 of the connecting part 321 in the electrode unit group C is two symmetrically arranged arcs up and down, the central angle corresponding to the boundary line 3211 is 40° - 44°, preferably 42°, the upper boundary line 3211 is arranged with both ends upturned, and the lower boundary line 3211 is arranged with both ends depressed.

[0051] Figure 18 Figure 4 is a distribution diagram of ten electrode unit groups C of the electrode patch 30. It is defined that the electrode unit groups C1, C2, C3, C5, C6, C8, C9, C10 located at the outer peripheral edge of the electrode patch 30 are peripheral electrode unit groups C, and the electrode unit groups C4, C7 located at the center of the electrode patch 30 are central electrode unit groups C. At least a part of the perimeter of each peripheral electrode unit group C constitutes the outer boundary M of the entire electrode array 32, and the part of the outer boundary M that coincides with each peripheral electrode unit group C does not exceed 10% of the perimeter of each peripheral electrode unit group C. And the outer boundary M has both concave partial boundaries and convex partial boundaries. Specifically, its upper and lower edges are arranged in a concave shape, and its left and right edges are arranged in a convex shape. There is a horizontal center line X2 and a vertical center line Y2 in the area where these ten electrode unit groups C are located, and these ten electrode unit groups C are symmetrically arranged along the horizontal center line X2 and the vertical center line Y2. The intersection point of the horizontal center line X2 and the vertical center line Y2 is the center point of these ten electrode unit groups C.

[0052] The electrode unit groups C4, C7 located at the centers of the second row and the third row are horizontally arranged, that is, the horizontal axis X1 of the electrode unit groups C4, C7 is a horizontal line parallel to the horizontal center line X2, and the other electrode unit groups C are all arranged obliquely relative to the horizontal center line X2, so that the centers of the electrode units 320 in each row are located on the same arc. It is defined that the centers of the electrode units 320 in the first row are located on the arc H1, the centers of the electrode units 320 in the second row are located on the arc H2, the centers of the electrode units 320 in the third row are located on the arc H3, and the centers of the electrode units 320 in the fourth row are on the arc H4. The arc H1 and the arc H4 are symmetric about the axis where the horizontal center line X2 is located, and the arc H2 and the arc H3 are symmetric about the axis where the horizontal center line X2 is located; the arcs H1, H2, H3, H4 are each symmetrically arranged along the vertical center line Y2; among them, the two ends of the arcs H1, H2 are upturned, and the two ends of the arcs H3, H4 are depressed.

[0053] Both electrode unit groups C1 and C2 are arranged in an inclined manner with respect to the horizontal center line X2 and are symmetric with respect to the vertical center line Y2. Taking the electrode unit group C1 as an example for illustration. The included angle a1 between the horizontal axis X1 of the electrode unit group C1 and the horizontal line is 8° - 12°, preferably 10°; the central angle corresponding to the arc segment AB of the electrode unit group C1 on the arc H1 is 11° - 21°, preferably 16°. In this embodiment, the radius of the circle where the arc H1 is located is about 192 mm, the central angle corresponding to the arc H1 is about 36°, and the arc length of the arc H1 is about 121 mm. In this example, the horizontal line is parallel to the horizontal center line X2.

[0054] Both electrode unit groups C3 and C5 are arranged in an inclined manner with respect to the horizontal center line X2 and are symmetric with respect to the vertical center line Y2. Taking the electrode unit group C3 as an example for illustration. The included angle a2 between the horizontal axis X1 of the electrode unit group C3 and the horizontal line is 8° - 12°, preferably 10°; the central angle corresponding to the arc segment DE of the electrode unit group C3 on the arc H2 is 7 - 11°, preferably 9°. In this embodiment, the radius of the circle where the arc H2 is located is about 361 mm, the central angle corresponding to the arc H2 is about 29°, and the arc length of the arc H2 is about 183 mm. The electrode unit group C4 is arranged horizontally with respect to the horizontal center line X2 and is symmetric along the vertical center line Y2.

[0055] The electrode unit group C9 and the electrode unit group C1, the electrode unit group C10 and the electrode unit group C2 are arranged symmetrically along the horizontal center line X2. The electrode unit group C6 and the electrode unit group C3, the electrode unit group C7 and the electrode unit group C4, the electrode unit group C8 and the electrode unit group C5 are arranged symmetrically along the horizontal center line X2. The relevant setting methods can refer to the relevant content of the electrode unit groups C1 to C5.

[0056] It can be understood that the arc lengths of arc segment AB and arc segment DE are close, but the central angle corresponding to arc segment AB is larger than the central angle corresponding to arc segment DE. That is to say, the curvature of arc H1 is greater than the curvature of arc H2, and arc H1 is more curved. The vertical distances between adjacent arcs H1, H2, H3, and H4 are basically the same, about 33 - 35 mm. The vertical distance between the centers of a electrode unit 320 in electrode unit group C1 that is far from the vertical center line Y2 and a electrode unit 320 in the third electrode unit group C3 that is close to the vertical center line Y2 is d1, that is, the vertical distance between the centers of two electrode units 320 located in the first row and the second row and both in the second column is d1, and d1 is about 38 mm. The vertical distance between the center of another electrode unit 320 in electrode unit group C1 that is close to the vertical center line Y2 and the center of a electrode unit 320 in the fourth electrode unit group C4 close to it is d2, that is, the vertical distance between the centers of two electrode units 320 located in the first row and the second row and both in the third column is d2, where d2 is less than d1, and d2 is about 35 mm. The horizontal dimension K1 of the gap between electrode unit groups C1 and C2 is about 11.5 mm, and the horizontal dimension K2 of the gap between electrode unit groups C3 and C4 is about 7.5 mm.

[0057] In addition, the current density flowing through the electrode unit 320 in the corresponding electrode unit assembly C can be improved by using dielectric layers 329 with different thicknesses, thereby improving the edge effect. In the electrode patch 30 of the tumor electric field therapy system 100 of the present application, the electrode units 320 of the electrode unit groups C at different positions have dielectric layers 329 with different thicknesses. Specifically, the thickness of the dielectric layer 329 of the electrode unit 320 of the electrode unit group C on the periphery of the electrode array 32 in the electrode patch 30 is greater than the thickness of the dielectric layer 329 of the electrode unit 320 of the electrode unit group C at the center of the electrode array 32 in the electrode patch 30. Further, the thickness of the dielectric layer 329 of the electrode unit 320 of the electrode unit group C at the corner of the periphery of the electrode array 32 in the electrode patch 30 is greater than the thickness of the dielectric layer 329 of the electrode unit 320 of the electrode unit group C at other positions on the periphery of the electrode array 32 but not at the corner. In this embodiment, each electrode unit group C includes two adjacent electrode units 320. It can be understood that in other embodiments, the electrode unit group C can also be replaced by a single electrode unit 320, that is, dielectric layers 329 with different thicknesses are provided for the electrode units 320 at different positions, and corresponding adhesive members 33 are respectively provided for each single electrode unit 320, and the remaining structures and the like are similar to those of the aforementioned electrode patch 30, which will not be elaborated here. With such a design, the current density of each electrode unit 320 in the entire electrode patch 30 can be made to tend to be consistent, the problem of the edge effect can be alleviated, the requirement for the application position of the electrode patch 30 can be reduced, thereby the maximum working current of the electrode patch 30 can be increased, the intensity of the tumor treatment electric field can be increased, and the tumor treatment effect can be enhanced. The present application provides the following three implementation schemes for the thickness of the dielectric layer 329 of each electrode unit 320:

[0058] First embodiment: The thickness of the dielectric layer 329 of each electrode unit 320 in the four electrode unit groups C1, C2, C9, and C10 at the corners of the periphery of the electrode array 32 in the electrode patch 30 is 0.015 mm, and the thickness of the dielectric layer 329 of each electrode unit 320 in the other electrode unit groups C3 to C8 is 0.005 mm. The ratio of the thickness of the dielectric layer 329 of each electrode unit 320 in the electrode unit groups C1, C2, C9, and C10 at the corners of the periphery of the electrode array 32 to the thickness of the dielectric layer 329 of each electrode unit 320 in the other electrode unit groups C3 to C8 is 3. The ratio of the thicknesses of the dielectric layer 329 of each electrode unit 320 in the electrode unit groups C at the center, the periphery but not at the corners, and the corners of the periphery of the electrode array 32 is 1:1:3.

[0059] Second Embodiment: The thickness of the dielectric layer 329 of each electrode unit 320 in the four electrode unit groups C1, C2, C9, and C10 at the outer corners of the electrode array 32 where the electrode patch 30 is located is 0.01 mm. The thickness of the dielectric layer 329 of each electrode unit 320 in the electrode unit groups C3, C5, C6, and C8 that are located on the periphery of the electrode array 32 but not at the corners is 0.007 mm. The thickness of the dielectric layer 329 of each electrode unit 320 in the electrode unit groups C4 and C7 at the center of the electrode array 32 where the electrode patch 30 is located is 0.005 mm. The ratio of the thickness of the dielectric layer 329 of the electrode unit 320 at the outer corners of the electrode array 32 to the thickness of the dielectric layer 329 of the electrode unit 320 at the center of the electrode array 32 is 2. The thickness ratio of the dielectric layer 329 of each electrode unit 320 in the three electrode unit groups C at the center, on the periphery but not at the corners, and at the outer corners of the electrode array 32 is 5:7:10.

[0060] Third Embodiment: The thickness of the dielectric layer 329 of each electrode unit 320 in the four electrode unit groups C1, C2, C9, and C10 at the outer corners of the electrode array 32 where the electrode patch 30 is located is 0.015 mm. The thickness of the dielectric layer 329 of each electrode unit 320 in the electrode unit groups C3, C5, C6, and C8 that are located on the periphery of the electrode array 32 but not at the corners is 0.01 mm. The thickness of the dielectric layer 329 of each electrode unit 320 in the electrode unit groups C4 and C7 at the center of the electrode array 32 where the electrode patch 30 is located is 0.005 mm. The ratio of the thickness of the dielectric layer 329 of the electrode unit 320 at the outer corners of the electrode array 32 to the thickness of the dielectric layer 329 of the electrode unit 320 at the center of the electrode array 32 is 3. The thickness ratio of the dielectric layer 329 of each electrode unit 320 in the three electrode unit groups C at the center, on the periphery but not at the corners, and at the outer corners of the electrode array 32 is 1:2:3.

[0061] In the first embodiment, the second embodiment, and the third embodiment, the electrode patch 30 has the same structure and size except that the dielectric layer 329 of the electrode unit 320 has different thicknesses.

[0062] Next, a modeling method is used to simulate the actual heat generation situation of the electrode patch 30 on the human body, and analyze the influence of the coverage area of the adhesive member 33 and the thickness of the dielectric layer 329 on the peak value of the current density of each electrode unit 310. Refer to Figure 6As shown in the figure, the electrode patches 30 are applied in pairs on both sides of the cubic structure, and the electrode units 320 correspond one by one. The width of the cubic structure refers to the abdominal circumference size of a normal adult male, 220mm * 200mm * 180mm, for phantom construction. In the tumor electric field therapy system 100, the materials, dimensions, and related electrical parameters of the dielectric layer 329, the conductive sheet 326, the adhesive 33, and the insulating cover film 328 on the electrode patch 30 are referred to the following table.

[0063]

[0064] Since two adjacent electrode units 320 form an electrode unit group C, and the dielectric layer 329 is laid on the electrode unit group C as a whole, each electrode unit group C is taken as the analysis object of current density; the connection part 321 between each electrode unit group C has its surface covered with the insulating cover film 328 and no dielectric layer 329, so its current density can be ignored.

[0065] Next, in combination with Comparative Example 1 to Comparative Example 3, first analyze the influence of the extension size of the adhesive 33 on the current density.

[0066] In Comparative Example 1: The extension size of the adhesive 33 is 3mm. The thickness of the dielectric layer 329 of each electrode unit 320 in each electrode unit group C is 0.005mm. In Comparative Example 2: The extension size of the adhesive 33 is 1mm. The thickness of the dielectric layer 329 of each electrode unit 320 in each electrode unit group C is 0.005mm. In Comparative Example 3: The extension size of the adhesive 33 is 0mm. The thickness of the dielectric layer 329 of each electrode unit 320 in each electrode unit group C is 0.005mm.

[0067] In the above 3 comparative examples, except for the different extension sizes of the adhesive 33, the parameters of the remaining structures of the electrode patch 30 are exactly the same. Apply an AC signal of ±80V (160Vpp), 150KHz to each electrode patch 30 in Comparative Example 1 to Comparative Example 3 for simulation, and calculate the differences in the edge effects (current density) caused by the three electrode patches 30 in Comparative Example 1 to Comparative Example 3 when only the extension size of the adhesive 33 is different through finite element simulation software.

[0068] Refer to Figure 8 and Figure 9As shown, it can be verified from the current density distribution of Comparative Example 1 and Comparative Example 3 that the edge effect does exist, that is, the electrode unit 320 where the electrode patch 30 is located at the periphery of the electrode array 32 has a lower resistance, resulting in a higher current density flowing through the electrode unit 320 where the electrode patch 30 is located at the periphery of the electrode array 32; and, the current density at the electrode unit 320 where the electrode patch 30 is located at the corner or similar sharp bend at the periphery of the electrode array 32 is higher than that at the other electrode units 320 located at the periphery of the electrode array 32.

[0069] Reference Figure 10 As shown Figure 10 The figure shows the peak current density of each electrode unit 320 in Comparative Example 1 to Comparative Example 3. From the data in the figure, it can be seen that as the extension size of the paste member 33 increases, that is, as the area of the paste member 33 increases, the peak current density of each electrode unit 320 decreases. That is, appropriately increasing the area of the paste member 33 can alleviate the edge effect problem of the electrode patch 30. Figure 11 The figure shows a comparison chart of the peak current density uniformity of each electrode unit 320 in Comparative Example 1 to Comparative Example 3, which shows that the standard deviation of the current density of each electrode unit 320 decreases as the extension size of the paste member 33 increases. Specifically, the standard deviation of the current density of each electrode unit 320 of the electrode patch 30 in Comparative Example 1 with the extension size of the paste member 33 being 3 mm is 2.8; the standard deviation of the current density of each electrode unit 320 of the electrode patch 30 in Comparative Example 2 with the extension size of the paste member 33 being 1 mm is 3.36; the standard deviation of the current density of each electrode unit 320 of the electrode patch 30 in Comparative Example 3 with the extension size of the paste member 33 being 0 mm is 4.83. It can be seen from this that the current density uniformity in Comparative Example 1 of the electrode patch 30 with the extension size of the paste member 33 being 3 mm is better, and the thermal effect of the electrode patch 30 is more uniform, which helps to improve the uniformity of the effective treatment electric field intensity in the target area and reduce the requirements for the application position.

[0070] Next, in combination with Comparative Example 4 to Comparative Example 6, the influence of the thickness of the dielectric layer 329 on the current density is analyzed.

[0071] Comparative Example 4: The thickness of the dielectric layer 329 of each electrode unit 320 in the four electrode unit groups C1, C2, C9, and C10 at the outer corner of the electrode array 32 of the electrode patch 30 is 0.015 mm, and the thickness of the dielectric layer 329 of each electrode unit 320 in the other electrode unit groups C3 to C8 is 0.005 mm. The thickness ratio of the dielectric layer 329 of each electrode unit 320 in the electrode unit groups C1, C2, C9, and C10 at the outer corner of the electrode array 32 to the dielectric layer 329 of each electrode unit 320 in the other electrode unit groups C3 to C8 is 3. The thickness ratio of the dielectric layer 329 of each electrode unit 320 in the electrode unit groups C at the center, outer but not at the corner, and outer corner of the electrode array 32 is 1:1:3.

[0072] Comparative Example 5: The thickness of the dielectric layer 329 of each electrode unit 320 in the four electrode unit groups C1, C2, C9, and C10 at the outer corner of the electrode array 32 of the electrode patch 30 is 0.01 mm, the thickness of the dielectric layer 329 of each electrode unit 320 in the electrode unit groups C3, C5, C6, and C8 at the outer but not at the corner of the electrode array 32 is 0.007 mm, and the thickness of the dielectric layer 329 of each electrode unit 320 in the electrode unit groups C4 and C7 at the center of the electrode array 32 is 0.005 mm. The thickness ratio of the dielectric layer 329 of the electrode unit 320 at the outer corner of the electrode array 32 to the dielectric layer 329 of the electrode unit 320 at the center of the electrode array 32 is 2. The thickness ratio of the dielectric layer 329 of the electrode unit 320 in the electrode unit groups C at the center, outer but not at the corner, and outer corner of the electrode array 32 is 5:7:10.

[0073] Comparative Example 6: The thickness of the dielectric layer 329 of each electrode unit 320 in the four electrode unit groups C1, C2, C9, and C10 at the outer corner of the electrode array 32 of the electrode patch 30 is 0.015 mm, the thickness of the dielectric layer 329 of each electrode unit 320 in the electrode unit groups C3, C5, C6, and C8 at the outer but not at the corner of the electrode array 32 is 0.01 mm, and the thickness of the dielectric layer 329 of each electrode unit 320 in the electrode unit groups C4 and C7 at the center of the electrode array 32 is 0.005 mm. The thickness ratio of the dielectric layer 329 of the electrode unit 320 at the outer corner of the electrode array 32 to the dielectric layer 329 of the electrode unit 320 at the center of the electrode array 32 is 3. The thickness ratio of the dielectric layer 329 of the electrode unit 320 in the electrode unit groups C at the center, outer but not at the corner, and outer corner of the electrode array 32 is 1:2:3.

[0074] In the foregoing Comparative Example 3, the thickness of the dielectric layer 329 of each electrode unit 320 is 0.005 mm. The thickness ratio of the dielectric layers 329 of the electrode units 320 at the center of the electrode array 32, at the periphery but not at the corners, and at the peripheral corners is 1:1:1.

[0075] In the above Comparative Examples 3 to 6, except for the difference in the thickness of the dielectric layer 329 in the electrode unit 320, the parameters of each structure of the remaining electrode patches 3 are exactly the same, and the extension dimensions of the adhesive members 33 in these 4 comparative examples are all 0 mm. Next, the differences in the edge effects (current density) caused by different thicknesses of the dielectric layer in the electrode unit 320 in Comparative Examples 4 to 6 are calculated through finite element simulation.

[0076] Refer to Figure 12 , and compare Figure 9 As shown, by observing the current density distribution of Comparative Example 3 and Comparative Example 4, it can be seen that the peak current density of the electrode unit groups C1, C2, C9, and C10 of the electrode patch 30 in Comparative Example 3 is the largest, followed by the electrode unit groups C3, C5, C6, and C8, and the smallest is the electrode unit groups C4 and C7. For the electrode patch 30 in Comparative Example 4, the peak current density of the electrode unit groups C3, C5, C6, and C8 is the largest, followed by the electrode unit groups C4 and C7, and the smallest is the electrode unit groups C1, C2, C9, and C10. Comparing the current density distributions of Comparative Example 3 and Comparative Example 4 reflects that, due to the increase in the thickness of the dielectric layer 329, the peak current density of these four electrode unit groups C among all the electrode unit groups C has dropped from the highest to the lowest. It can be seen that increasing the thickness of the dielectric layer 329 of the electrode unit 320 at the peripheral corners of the electrode array 32 can effectively reduce the peak current density of the corresponding electrode unit 320.

[0077] Refer to Figures 12 to 14 , and in combination with Figure 15 and Figure 16 as shown, Figure 15 shows the maximum peak current density in each electrode unit 320 in Comparative Examples 3 to 6, Figure 16 is the comparison of the peak current density uniformity in each electrode unit 320 in Comparative Examples 3 to 6. Specifically, refer to Figure 15 , which shows that the maximum peak current density of each electrode unit 320 of the electrode patch 30 in Comparative Example 3, where the extension dimension of the adhesive member 33 is 0 mm and the thickness of the dielectric layer 329 of each electrode unit 320 in each electrode unit group C is 0.005 mm, is 42.165 mA / cm 2; The maximum peak current density of each electrode unit 320 of the electrode patch 30 of Comparative Example 4, where the outer dimension of the adhesive 33 is 0 mm and the dielectric layer 329 of each electrode unit 320 in the four electrode unit groups C1, C2, C9, and C10 located at the corners of the electrode array 32 has a thickness of 0.015 mm, and the dielectric layer 329 of each electrode unit 320 in the other electrode unit groups C3 to C8 has a thickness of 0.005 mm, is 41.429 mA / cm 2 ; The maximum peak current density of each electrode unit 320 of the electrode patch 30 of Comparative Example 5, where the outer dimension of the adhesive 33 is 0 mm and the dielectric layer 329 of each electrode unit 320 in the four electrode unit groups C1, C2, C9, and C10 located at the corners of the electrode array 32 has a thickness of 0.01 mm, the dielectric layer 329 of each electrode unit 320 in the electrode unit groups C3, C5, C6, and C8 located on the periphery of the electrode array 32 but not at the corners has a thickness of 0.007 mm, and the dielectric layer 329 of each electrode unit 320 in the electrode unit groups C4 and C7 located at the center of the electrode array 32 has a thickness of 0.005 mm, is 40.959 mA / cm 2 ; The maximum peak current density of each electrode unit 320 of the electrode patch 30 of Comparative Example 6, where the outer dimension of the adhesive 33 is 0 mm and the dielectric layer 329 of each electrode unit 320 in the four electrode unit groups C1, C2, C9, and C10 located at the corners of the electrode array 32 has a thickness of 0.015 mm, the dielectric layer 329 of each electrode unit 320 in the electrode unit groups C3, C5, C6, and C8 located on the periphery of the electrode array 32 but not at the corners has a thickness of 0.01 mm, and the dielectric layer 329 of each electrode unit 320 in the electrode unit groups C4 and C7 located at the center of the electrode array 32 has a thickness of 0.005 mm, is 38.079 mA / cm 2 。Reference Figure 16, it shows that the standard deviation of the current density of each electrode unit 320 of the electrode patch 30 of Comparative Example 3, where the outer dimension of the paste member 33 is 0 mm and the thickness of the dielectric layer 329 of each electrode unit 320 in each electrode unit group C is 0.005 mm, is 4.83; the standard deviation of the current density of each electrode unit 320 of the electrode patch 30 of Comparative Example 4, where the outer dimension of the paste member 33 is 0 mm and the thickness of the dielectric layer 329 of each electrode unit 320 in the four electrode unit groups C1, C2, C9, and C10 at the corners of the electrode array 32 is 0.015 mm and the thickness of the dielectric layer 329 of each electrode unit 320 in the other electrode unit groups C3 to C8 is 0.005 mm, is 4.77; the standard deviation of the current density of each electrode unit 320 of the electrode patch 30 of Comparative Example 5, where the outer dimension of the paste member 33 is 0 mm and the thickness of the dielectric layer 329 of each electrode unit 320 in the four electrode unit groups C1, C2, C9, and C10 at the corners of the electrode array 32 is 0.01 mm, the thickness of the dielectric layer 329 of each electrode unit 320 in the electrode unit groups C3, C5, C6, and C8 located on the periphery of the electrode array 32 but not at the corners is 0.007 mm, and the thickness of the dielectric layer 329 of each electrode unit 320 in the electrode unit groups C4 and C7 at the center of the electrode array 32 is 0.005 mm, is 3.52; the standard deviation of the current density of each electrode unit 320 of the electrode patch 30 of Comparative Example 6, where the outer dimension of the paste member 33 is 0 mm and the thickness of the dielectric layer 329 of each electrode unit 320 in the four electrode unit groups C1, C2, C9, and C10 at the corners of the electrode array 32 is 0.015 mm, the thickness of the dielectric layer 329 of each electrode unit 320 in the electrode unit groups C3, C5, C6, and C8 located on the periphery of the electrode array 32 but not at the corners is 0.01 mm, and the thickness of the dielectric layer 329 of each electrode unit 320 in the electrode unit groups C4 and C7 at the center of the electrode array 32 is 0.005 mm, is 3.30. From Figure 9 , Figures 12 to 16 it can be seen that by setting different thicknesses for the dielectric layers 329 of the electrode units 320 at different positions in the electrode array 32, the maximum current density peak in the entire electrode patch 30 can be effectively reduced, and compared with simply increasing the thickness of the dielectric layer 329 of some electrode units 320, the stepped setting of the thicknesses of the dielectric layers 329 of the electrode units 320 at different positions shows better performance in terms of current density uniformity. Specifically, by selecting different thicknesses of the dielectric layer 329 according to the different positions of the electrode units 320 in the electrode patch 30, the current density peak of each electrode unit 320 flowing through the electrode patch 30 can be effectively reduced, and the current density and heat generation of each electrode unit 320 can be balanced.

[0078] For the electrode patch 30 of the tumor electrotherapy system 100 of the present application, according to the influence of the thickness of the dielectric layer 329 on the current density, dielectric layers 329 with different thicknesses are provided for the electrode units 320 of the electrode unit groups C at different positions. Specifically, the thickness of the dielectric layer 329 in the electrode unit 320 of the electrode unit group C located at the periphery of the electrode array 32 is greater than the thickness of the dielectric layer 329 in the electrode unit 320 of the electrode unit group C located at the center of the electrode array 32. More preferably, the thickness of the dielectric layer 329 in the electrode unit 320 of the electrode unit group C located at the corner of the electrode array 32 is greater than the thickness of the dielectric layer 329 in the electrode unit 320 located at other positions on the periphery of the electrode array 32 but not at the corner, and the thickness of the dielectric layer 329 in the electrode unit 320 of the electrode unit group C located at the center of the electrode array 32 is the smallest. Such a design can make the current density of the electrode units 320 at various positions on the entire electrode patch 30 tend to be consistent, relieve the problem of edge effect, reduce the requirements for the attachment position of the electrode patch 30, thereby increasing the maximum working current of the electrode patch 30, enhancing the intensity of the tumor treatment electric field, and improving the tumor treatment effect.

[0079] The above are only the preferred embodiments of the present application and are not intended to limit the present application. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present application shall be included within the scope of protection of the present application.

Claims

1. An electrode patch, comprising an electrode array and a plurality of adhesive members. The electrode array includes a plurality of electrode units for alternating current signals to pass through and a plurality of connecting portions located between the plurality of electrode units and connecting adjacent two electrode units. Each electrode unit includes a main body portion, a conductive sheet provided on the main body portion, and a dielectric layer covering the conductive sheet and electrically connected to the conductive sheet, characterized in that: Two adjacent electrode units and the connecting part electrically connecting the two electrode units form an electrode unit group, and a plurality of adhesive parts cover the corresponding electrode unit groups. When an alternating current signal is applied to the electrode array, the current flowing through each electrode unit has a balanced current density; The electrode array includes ten electrode unit groups C1 to C10 arranged in four rows. The electrode unit groups C1 and C2 are located in the first row, the electrode unit groups C3, C4, and C5 are located in the second row, the electrode unit groups C6, C7, and C8 are located in the third row, and the electrode unit groups C9 and C10 are located in the fourth row. A horizontal center line and a vertical center line are provided in the area where the electrode unit groups are located. Each electrode unit group has its own horizontal axis and vertical axis. The horizontal axis of the electrode unit group located at the center of the electrode array is arranged parallel to the horizontal center line. The horizontal axes of the electrode unit groups located on the periphery of the electrode array are symmetric and inclined with respect to the horizontal center line and the vertical center line, so that the centers of the electrodes in each row are located on the same arc with both ends upturned or downturned. Among them, the included angle between the horizontal axis of each electrode unit group located on the periphery of the electrode array and the horizontal line is 8°-12°. It is defined that the centers of the several electrodes in each row from the first row to the fourth row are successively located on the arcs H1, H2, H3, and H4. The two ends of the arcs H1 and H2 are upturned, and the two ends of the arcs H3 and H4 are downturned. Among them, the curvature of the arc H1 is greater than the curvature of the arc H2; The dielectric layer covering the conductive sheets of the two electrode units in each electrode unit group also continuously covers the connecting part in the electrode unit group. The dielectric layer does not cover the connecting part between the electrode unit groups. The dielectric layer in the same electrode unit group is uniformly arranged and has the same thickness. The dielectric layers in different electrode unit groups have different thicknesses. Among them, the thickness of the dielectric layer in the electrode unit groups C1, C2, C3, C5, C6, C8, C9, and C10 located on the periphery of the electrode array is greater than the thickness of the dielectric layer in the electrode unit groups C4 and C7 located at the center of the electrode array. The thickness of the dielectric layer in the electrode unit groups C1, C2, C9, and C10 located at the corners on the periphery of the electrode array is greater than the thickness of the dielectric layer in the other electrode unit groups C3, C5, C6, and C8 located on the periphery of the electrode array.

2. The electrode patch according to claim 1, wherein: The boundary line of the connecting part in each electrode unit group is two symmetric upper and lower arcs, and the central angle corresponding to the boundary line is 40°-44°. The boundary line of the connecting part located on the upper side is arranged with both ends upturned, and the boundary line of the connecting part located on the lower side is arranged with both ends downturned.

3. The electrode patch according to claim 1, wherein: At least a part of the perimeter of the electrode unit group located on the periphery of the electrode array coincides with the outer boundary of the electrode array, and the coincident part does not exceed 10% of the perimeter of the electrode unit group.

4. The electrode patch according to claim 1, wherein: The dielectric layer thickness ratios of the electrode units of each of the electrode unit groups located at the center of the electrode array, at the periphery of the electrode array but not at the corners, and at the corners of the periphery of the electrode array are 1:2:3 or 1:1:3 or 5:7:

10.

5. The electrode patch according to claim 1, wherein: The dielectric layer thickness of the electrode units located at the center of the electrode array is 0.005 mm; the thickness of the dielectric layer of each electrode unit located at the corners of the periphery of the electrode array is 0.01 mm to 0.015 mm, and the dielectric layer thickness of the electrode units located at the periphery of the electrode array but not at the corners is 0.005 mm to 0.10 mm.

6. The electrode patch according to claim 1, wherein: The central angle corresponding to the arc segment of the electrode unit group C1 in the first row on the arc H1 is 11° - 21°, and the central angle corresponding to the arc segment of the electrode unit group C3 in the second row on the arc H2 is 7 - 11°.

7. The electrode patch according to claim 1, wherein: Each of the electrode unit groups has the same structure and dimensions except for the different dielectric layer thicknesses.

8. The electrode patch according to claim 1, wherein: The adhesive is a hydrogel, and the adhesive has an extension dimension that extends beyond the corresponding edge of the main body portion on one side, and the extension dimension ranges from 0 mm to 3 mm.

9. A tumor electrotherapy system, characterized in that: It includes an electric field generator, an adapter, and several pairs of electrode patches as described in any one of claims 1 to 8, and the adapter is electrically connected to the electric field generator and each of the electrode patches.

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