Multi-core Salen catalyst and preparation method and application thereof

By developing multi-core Salen catalysts and using amide bonds to connect single-core catalysts, the problems of low efficiency and high cost of existing Salen catalysts in chiral synthesis have been solved, achieving a more efficient and economical catalytic effect, which is suitable for industrial production.

CN119684154AActive Publication Date: 2025-03-25HUBEI GRAND LIFE SCI & TECH CO LTD
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Patent Information

Application Number
CN202411596877.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-11-08
Publication Date
2025-03-25
Estimated Expiration
2044-11-08

AI Technical Summary

Technical Problem

In chiral synthesis, existing Salen catalysts have problems such as low catalytic efficiency, long reaction time, difficult to control catalyst activity, rare preparation raw materials, and harsh reaction conditions, resulting in high costs and unsuitable for industrial production.

Method used

A multi-nuclear Salen catalyst is developed to connect the mononuclear catalyst into a multi-nuclear catalyst through groups containing amide bonds, simplifying the preparation method, mildening the reaction conditions, and improving catalytic efficiency and recovery.

Benefits of technology

It has achieved shortening reaction time, improving catalytic efficiency, improving resolution yield, improving catalyst recovery rate and recovery activity, and is suitable for industrial production.

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Abstract

The invention discloses a Salen catalyst. The Salen catalyst has a structure as shown in a formula (I-1). The Salen catalyst is a multi-core catalyst, two or more mononuclear catalysts can be connected into the multi-core catalyst through groups containing amido bonds, the catalytic efficiency, the resolution yield, the recovery rate and the activity after recovery of the catalyst can be improved, and the recovered catalyst can be mixed with a fresh multi-core catalyst for use; and the method still has the advantages of high resolution yield and the like, and can be recycled for multiple times. Besides, when the multinuclear catalyst participates in the resolution reaction, excessive water is not needed, the reaction yield can be increased, the time for splitting the terminal epoxy compound can be shortened, the prepared product is high in purity and few in impurity, and the problems that the final product is difficult to purify and the like can be solved. # imgabs0 #
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