Intelligent biological tissue slicer

Abstract

The invention discloses an intelligent biological tissue slicing machine, and relates to the technical field of medical instruments, the intelligent biological tissue slicing machine comprises a displacement area and a cutting and scooping area, the displacement area is covered with a shell, and the displacement area is fixedly connected with the cutting and scooping area; the displacement area comprises a vertical linear motor, a transverse linear motor and a bottom plate, the transverse linear motor is fixedly mounted in the middle of the upper surface of the bottom plate, and the vertical linear motor is fixedly mounted on a rotor seat of the transverse linear motor; a wax block clamping assembly is mounted on a rotor seat of the vertical linear motor; the cutting and slicing area comprises a water storage disc and a cutting assembly, and the cutting assembly is mounted in the water storage disc; the cutting assembly corresponds to the wax block clamping assembly in position. According to the intelligent biological tissue slicing machine, manual intervention is reduced through intelligent control, the wax block feeding precision is guaranteed, wax block static electricity can be removed, wax block chippings can be rapidly sucked and removed, slicing and fishing integrated design is achieved, and the slicing quality is guaranteed.

Description

Technical Field

[0001] The invention relates to the technical field of medical devices, and in particular to an intelligent biological tissue slicer. Background Art

[0002] Biological tissue slicers are machines for cutting thin and uniform tissue slices. Biological tissues are supported by hard paraffin or other substances. Each time a slice is cut, the slice thickness gauge automatically advances the required distance (towards the direction of the knife). The thickness gauge gradient is usually 1 micron. When cutting paraffin-embedded tissues, multiple slices are made due to adhesion to the wax edge of the previous slice.

[0003] The existing biological tissue slicer has the following shortcomings:

[0004] 1) The debris generated during trimming often requires the operator to clean it with a brush, which is inconvenient, and the remaining debris will adhere to the cut tissue sections, affecting the subsequent observation effect;

[0005] 2) The cutting process is affected by static electricity, resulting in a low yield rate;

[0006] 3) There are many processes involving human intervention during the operation, and the intelligence is low, which is not conducive to ensuring the quality of the film;

[0007] 4) After slicing, the slices need to be transferred to a water bath for slicing, which has low integration and is not conducive to reducing the floor space of the laboratory;

[0008] 5) It is difficult to ensure the accuracy during the feeding process of the wax block, which may easily lead to uneven thickness of the slices;

[0009] 6) In order to ensure the quality and speed of slicing, operators need to practice a lot.

[0010] How to develop an intelligent biological tissue slicer that can ensure the feeding accuracy of wax blocks, remove static electricity from wax blocks, quickly absorb debris, realize an integrated design of slicing and scooping, and reduce manual intervention has become a technical problem that needs to be urgently solved by technical personnel in this field. Summary of the invention

[0011] The purpose of the present invention is to provide an intelligent biological tissue slicer to solve the problems listed in the background technology.

[0012] In order to solve the above technical problems, the present invention adopts the following technical solutions:

[0013] The present invention discloses an intelligent biological tissue slicer, comprising a displacement area and a cutting and scooping area, wherein the outer cover of the displacement area is covered with a shell, and the displacement area is fixedly connected to the cutting and scooping area;

[0014] The displacement area includes a vertical linear motor, a horizontal linear motor and a bottom plate, the horizontal linear motor is fixedly installed in the middle of the upper surface of the bottom plate, and the vertical linear motor is fixedly installed on the mover seat of the horizontal linear motor;

[0015] A wax block clamping assembly is installed on the mover seat of the vertical linear motor;

[0016] The cutting and scooping area includes a water storage tray and a cutting assembly, and the cutting assembly is installed inside the water storage tray;

[0017] The cutting assembly corresponds to the position of the wax block clamping assembly.

[0018] Preferably, the vertical linear motor is vertically fixedly connected to the horizontal linear motor;

[0019] A guide groove is provided on the upper surface of the bottom plate, and the mover seat of the horizontally placed linear motor slides in the guide groove.

[0020] Preferably, the wax block clamping assembly comprises a connecting arm and a clamping plate, a servo motor is installed inside the connecting arm, and a working end of the servo motor is fixedly connected to the gear shaft;

[0021] The clamping plate is fixedly connected to one end of the rack;

[0022] The other end of the rack passes through the connecting arm and meshes with the gear shaft;

[0023] There are four racks, and two racks parallel to each other form a group;

[0024] The installation positions of the two groups of racks are staggered.

[0025] Preferably, the cutting assembly comprises a knife holder, and the knife holder is fixedly mounted on the upper surface of the water storage tray; a guide plate is mounted on the upper surface of the knife holder, and a knife clamp is fixedly mounted on the upper end of the guide plate;

[0026] A water distribution plate is installed at the joint between the knife clamp and the guide plate, and the water distribution plate is installed on the upper surface of the guide plate;

[0027] The water distribution plate is communicated with the tool holder through a conduit.

[0028] Preferably, the water distribution plate is hollow inside, and fine through holes are evenly opened on the side walls of the water distribution plate.

[0029] Preferably, a position regulator and a water pump are installed inside the tool holder, and the position regulator is movably connected to the guide plate;

[0030] The water inlet end of the water pump is communicated with the water storage tray, and the water outlet end of the water pump is communicated with the water distribution plate through the conduit.

[0031] Preferably, it further comprises an equipment rack, wherein the equipment rack is fixedly installed inside the water storage tray;

[0032] A camera is installed in the middle of the equipment rack, and an atomizing nozzle and a negative pressure suction head are respectively installed at both ends of the camera.

[0033] Preferably, a heater and a temperature control sensor are installed inside the water storage tray.

[0034] Compared with the prior art, the beneficial technical effects of the present invention are:

[0035] 1) When the wax block embedded with tissue is fixedly installed in the displacement zone, the wax block can be accurately fed by the horizontal linear motor and the vertical linear motor, without manual driving through the hand wheel. On the one hand, vibration is avoided when the hand wheel is driven, and disturbance to the wax block clamping assembly is prevented, which affects the slice quality and ensures that the thickness of the tissue slice remains uniform and stable. On the other hand, the workload of the operator can be reduced when the hand wheel is driven, which is convenient for freeing the operator's hands. After the slice is completed, the slice picking operation can be completed synchronously, which reduces the preparation time of the tissue slice;

[0036] 2) When the servo motor is working, it can drive the gear shaft to drive the rack to move along the track in the connecting arm, so that the clamping plate can expand and contract in all directions to complete the clamping operation of the wax block. In the clamping process, it can adapt to wax blocks of larger sizes, expanding the clamping range of the wax block clamping assembly for the size of the wax block;

[0037] 3) After the cutting blade on the knife holder cuts the wax block into slices, the lower surface of the slices contacts the upper surface of the water flow from the water distribution plate, and the slices flow into the water storage tray driven by the water flow, which makes it convenient for the operator to separate the slices with tweezers and use a glass slide to fish out the slices, thus realizing the integrated operation of slicing and fishing, and reducing the floor space of the laboratory;

[0038] 4) The camera can convert the state of the slices on the guide plate into image signals, transmit them to the image processing system, obtain the morphological information of the slices, and convert them into digital signals based on pixel distribution, brightness, color and other information; the image system performs various operations on these signals to extract the characteristics of the target, and then controls the working states of the vertical linear motor, horizontal linear motor, water pump, atomizing nozzle, and negative pressure suction head based on the judgment results.

[0039] In general, the present invention reduces manual intervention through intelligent control, ensures the feeding accuracy of the wax block, and can also remove static electricity on the wax block, quickly absorb wax block debris, realize an integrated design of slicing and scooping, and ensure the quality of slicing, making it easy for inexperienced personnel to quickly complete slicing and slicing preparation operations. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] The present invention will be further described below in conjunction with the accompanying drawings.

[0041] Figure 1 A three-dimensional schematic diagram of an intelligent biological tissue slicer according to the present invention Figure 1 (without casing);

[0042] Figure 2 It is a side view schematic diagram of an intelligent biological tissue slicer of the present invention (without housing);

[0043] Figure 3 A three-dimensional schematic diagram of an intelligent biological tissue slicer according to the present invention Figure 2 (without casing);

[0044] Figure 4 A three-dimensional schematic diagram of an intelligent biological tissue slicer according to the present invention Figure 2 (without enclosure and equipment rack);

[0045] Figure 5 Schematic diagram of the wax block clamping assembly of the present invention (without connecting arm).

[0046] Explanation of the accompanying reference numerals: 1. Water storage tray; 2. Guide plate; 3. Water distribution plate; 4. Equipment rack; 5. Camera; 6. Atomizing nozzle; 7. Vertical linear motor; 8. Connecting arm; 9. Horizontal linear motor; 10. Bottom plate; 11. Tool clamp; 12. Snap-on plate; 13. Tool holder; 14. Gear shaft; 15. Rack; 16. Negative pressure suction head. DETAILED DESCRIPTION

[0047] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0048] like Figure 1-5 As shown, an intelligent biological tissue slicer comprises a displacement area and a cutting and scooping area, wherein the outer cover of the displacement area is covered with a shell, and the displacement area is fixedly connected to the cutting and scooping area;

[0049] The displacement area includes a vertical linear motor 7, a horizontal linear motor 9 and a bottom plate 10. The horizontal linear motor 9 is fixedly installed in the middle of the upper surface of the bottom plate 10, and the vertical linear motor 7 is fixedly installed on the mover seat of the horizontal linear motor 9. The vertical linear motor and the horizontal linear motor are used for precise feeding, which facilitates fast and accurate slice output and reduces adverse phenomena such as slice stacking and breakage.

[0050] A wax block clamping assembly is installed on the mover seat of the vertical linear motor 7;

[0051] The cutting and scooping area includes a water storage tray 1 and a cutting assembly, and the cutting assembly is installed inside the water storage tray 1;

[0052] The cutting assembly corresponds to the wax block clamping assembly in position;

[0053] When working, when the wax block embedded with tissue is fixedly installed in the displacement zone, the wax block can be accurately fed by the horizontal linear motor and the vertical linear motor, without manual driving through the hand wheel. On the one hand, it avoids vibration when driving the hand wheel, prevents disturbance to the wax block clamping assembly, affects the slice quality, and ensures that the thickness of the tissue slice remains uniform and stable. On the other hand, it can reduce the workload of the operator when the hand wheel is driven, free the operator's hands, and can simultaneously complete the slice catching operation after the slice is completed, reducing the preparation time of the tissue slice.

[0054] Furthermore, the feed distance of the vertical linear motor and the horizontal linear motor is fed back to the control system via a laser distance sensor to achieve precise control of the feed distance;

[0055] The water storage tray is filled with hot water. When the slicing belt enters the water storage tray, it is convenient for the operator to complete the slicing operation;

[0056] It can help people without operating experience to quickly get started, and can ensure the slice quality and slice preparation speed.

[0057] Specifically, the vertical linear motor 7 is vertically fixedly connected to the horizontal linear motor 9;

[0058] A guide groove is provided on the upper surface of the base plate 10, and the mover seat of the horizontally placed linear motor 9 slides in the guide groove. The provision of the guide groove ensures the stability and accuracy during the feeding process of the wax block.

[0059] Specifically, the wax block clamping assembly includes a connecting arm 8 and a clamping plate 12, a servo motor is installed inside the connecting arm 8, and a working end of the servo motor is fixedly connected to a gear shaft 14;

[0060] The clamping plate 12 is fixedly connected to one end of the rack 15;

[0061] The other end of the rack 15 passes through the connecting arm 8 and meshes with the gear shaft 14;

[0062] There are four racks 15, and two racks 15 parallel to each other form a group;

[0063] The installation positions of the two groups of racks 15 are staggered;

[0064] During operation, the rotation of the servo motor further drives the gear shaft to drive the rack to move along the track in the connecting arm, so that the clamping plate can extend and contract in all directions to complete the clamping operation of the wax block. During the clamping process, it can adapt to larger wax blocks and expand the clamping range of the wax block clamping assembly for the wax block size.

[0065] Specifically, the cutting assembly includes a knife holder 13, which is fixedly mounted on the upper surface of the water storage tray 1; a guide plate 2 is mounted on the upper surface of the knife holder 13, and a knife clamp 11 is fixedly mounted on the upper end of the guide plate 2, and a cutting blade can be clamped on the knife clamp;

[0066] A water distribution plate 3 is installed at the joint between the knife clamp 11 and the guide plate 2, and the water distribution plate 3 is installed on the upper surface of the guide plate 2;

[0067] The water distribution plate 3 is connected to the tool holder 13 through a conduit;

[0068] During operation, after the cutting blade on the knife clamp cuts the wax block into slice strips, the lower surface of the slice strips contacts the upper surface of the water flow out of the water distribution plate, and the slice strips flow into the water storage tray driven by the water flow, making it convenient for the operator to use tweezers to separate the slice strips and use a glass slide to fish out the slices, realizing the integrated operation of slicing and fishing, and reducing the laboratory's footprint.

[0069] Specifically, the water distribution plate 3 is hollow inside, and fine through holes are evenly opened on the side walls of the water distribution plate 3. The water distribution plate ensures that there is uniform water flow on the upper surface of the guide plate, avoiding the uneven water flow on the guide plate causing stacking of the slicing belt and other adverse phenomena.

[0070] Specifically, a position regulator and a water pump are installed inside the tool holder 13. The position regulator is movably connected to the guide plate 2. The position regulator can adjust the position and angle of the guide plate, and further complete the position and angle adjustment of the tool holder. The position regulator can adopt a Hooke hinge;

[0071] The water inlet end of the water pump is communicated with the water storage tray 1 , and the water outlet end of the water pump is communicated with the water distribution plate 3 through the conduit.

[0072] Specifically, it also includes an equipment rack 4, and the equipment rack 4 is fixedly installed inside the water storage tray 1;

[0073] A camera 5 is installed in the middle of the equipment frame 4, and an atomizing nozzle 6 and a negative pressure suction head 16 are installed at both ends of the camera 5. The camera can convert the state of the slices on the guide plate into an image signal, which is transmitted to the image processing system to obtain the morphological information of the slices, and convert it into a digital signal according to the pixel distribution, brightness, color and other information; the image system performs various operations on these signals to extract the characteristics of the target, and then controls the working states of the vertical linear motor, the horizontal linear motor, the water pump, the atomizing nozzle, and the negative pressure suction head according to the results of the judgment;

[0074] Furthermore, the pipes of the atomizing nozzle and the negative pressure nozzle can be bent and have a certain rigidity, and the water mist sprayed by the atomizing nozzle can be brought into contact with the wax block through the bent pipe to eliminate static electricity on the surface of the wax block;

[0075] Ensure that the negative pressure suction head can absorb the wax debris generated during the repair process to ensure the cleanliness of the guide plate;

[0076] When working, the camera takes pictures of the guide plate. When performing film repair, the camera transmits the recognized signal to the control system, and the control system sends a command to the fan connected to the negative pressure suction head, so that the fan drives the negative pressure suction head to work and suck the debris on the guide plate. When performing slicing, the camera transmits the recognized signal to the control system, and controls the fan to stop working through the control system, and synchronously controls the atomizer connected to the atomizing nozzle to spray water mist on the wax block to eliminate static electricity on the surface of the wax block;

[0077] At the same time, the camera can identify the number of slices on the slicing belt to ensure that the number of slices on each slicing belt remains at a certain value, making it convenient for operators to use glass slides to fish out slices in the water storage tray, thereby avoiding continuous operation of the vertical linear motor and the horizontal linear motor to generate a large number of slicing belts in the water storage tray, causing the slices to stack on each other and affecting the quality of the slicing.

[0078] Specifically, a heater and a temperature control sensor are installed inside the water storage tray 1. The heater and the temperature control sensor in the water storage tray cooperate to control the water temperature in the water storage tray within a temperature range of 30-50°C. The temperature can be adjusted specifically according to the wax blocks of different tissues to avoid wrinkles on the slices in the water storage tray.

[0079] Among them, the control program in the control system is known and can be implemented by those skilled in the art, and will not be described in detail here.

[0080] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0081] The embodiments described above are only descriptions of the preferred modes of the present invention, and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by ordinary technicians in this field should all fall within the protection scope determined by the claims of the present invention.

Claims

1. An intelligent biological tissue slicer, characterized in that: It includes a displacement area and a cutting and scooping area, the outer cover of the displacement area is covered with a shell, and the displacement area is fixedly connected to the cutting and scooping area; The displacement zone comprises a vertical linear motor (7), a horizontal linear motor (9) and a base plate (10); the horizontal linear motor (9) is fixedly mounted in the middle of the upper surface of the base plate (10); and the vertical linear motor (7) is fixedly mounted on a mover seat of the horizontal linear motor (9); A wax block clamping assembly is installed on the mover seat of the vertical linear motor (7); The cutting and scooping area comprises a water storage tray (1) and a cutting assembly, wherein the cutting assembly is installed inside the water storage tray (1); The cutting assembly corresponds to the position of the wax block clamping assembly.

2. The intelligent biological tissue slicer according to claim 1, characterized in that: The vertical linear motor (7) is vertically fixedly connected to the horizontal linear motor (9); A guide groove is provided on the upper surface of the base plate (10), and a mover seat of the horizontally placed linear motor (9) slides in the guide groove.

3. The intelligent biological tissue slicer according to claim 1, characterized in that: The wax block clamping assembly comprises a connecting arm (8) and a clamping plate (12); a servo motor is installed inside the connecting arm (8); and a working end of the servo motor is fixedly connected to a gear shaft (14); The clamping plate (12) is fixedly connected to one end of the rack (15); The other end of the rack (15) passes through the connecting arm (8) and meshes with the gear shaft (14); Four racks (15) are provided, and two racks (15) parallel to each other form a group; The installation positions of the two groups of racks (15) are staggered.

4. The intelligent biological tissue slicer according to claim 3, characterized in that: The cutting assembly comprises a knife holder (13), wherein the knife holder (13) is fixedly mounted on the upper surface of the water storage tray (1); a guide plate (2) is mounted on the upper surface of the knife holder (13), and a knife clamp (11) is fixedly mounted on the upper end of the guide plate (2); A water distribution plate (3) is installed at the joint between the knife clamp (11) and the guide plate (2), and the water distribution plate (3) is installed on the upper surface of the guide plate (2); The water distribution plate (3) is connected to the tool holder (13) via a conduit.

5. The intelligent biological tissue slicer according to claim 4, characterized in that: The water distribution plate (3) is hollow inside, and the side wall of the water distribution plate (3) is evenly provided with fine through holes.

6. The intelligent biological tissue slicer according to claim 4, characterized in that: A position regulator and a water pump are installed inside the tool holder (13), and the position regulator is movably connected to the guide plate (2); The water inlet end of the water pump is in communication with the water storage tray (1), and the water outlet end of the water pump is in communication with the water distribution plate (3) via the conduit.

7. The intelligent biological tissue slicer according to claim 1, characterized in that: It also includes an equipment rack (4), wherein the equipment rack (4) is fixedly installed inside the water storage tray (1); A camera (5) is installed in the middle of the equipment frame (4), and an atomizing nozzle (6) and a negative pressure suction head (16) are respectively installed at both ends of the camera (5).

8. The intelligent biological tissue slicer according to claim 1, characterized in that: A heater and a temperature control sensor are installed inside the water storage tray (1).

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