Low-residue synergistic pesticide composition

Abstract

The invention belongs to the technical field of pesticides, and particularly relates to a low-residue synergistic pesticide composition. The invention relates to a low-residue synergistic pesticide composition. The low-residue synergistic pesticide composition comprises an active component a and an active component b, the active component a is flurobixafen, and the active component b is trifluoropyridinamine or silthiopham. Compared with single use of flurobixafen, trifluoropyridinamine or silthiopham, the pesticide composition disclosed by the invention has the following advantages that the pesticide composition has a synergistic effect on plant diseases, the use dosage of the pesticide composition can be reduced, the prevention and treatment cost and pesticide residues are reduced, and the environmental pressure is relieved; besides, the two active components are reasonably compounded according to different action modes and different action mechanisms of the two active components on plant diseases, so that the development of drug resistance of the diseases can be delayed, and the service life of the active components can be prolonged.

Description

Technical Field

[0001] The invention belongs to the technical field of pesticides, and in particular relates to a low-residue synergistic pesticide composition. Background Art

[0002] Chlorofluanid is a biphenylpyrazole amide fungicide, English name: bixafen, also known as: bixafen, CAS number: 581809-46-3, molecular formula: C 18 H 12 Cl2F3N3O, the chemical structure is as follows:

[0003]

[0004] The mode of action of clofoxanil is a succinate dehydrogenase inhibitor (FRAC category: Group 7), that is, a respiratory inhibitor, which acts on the complex II succinate dehydrogenase in the respiratory electron transport chain of the pathogen's mitochondria, inhibiting mitochondrial function, hindering energy metabolism, inhibiting the growth of pathogens, and ultimately leading to their death. Clofoxanil is widely used in the prevention and control of various diseases in grain fields. It has good activity against powdery mildew, gray mold and other plant diseases caused by ascomycetes, basidiomycetes and deuteromycetes, and has protective and therapeutic effects. At the same time, studies have shown that clofoxanil can induce physiological changes in wheat plants, such as synchronous heading, increasing green leaf area, delaying plant senescence, and improving the physiological activity and yield of the ear during the filling period.

[0005] Although clofoxacin has the above advantages, as a single active ingredient, long-term and large-scale use will lead to the risk of drug resistance, excessive pesticide residues and reduced control effects. Therefore, it should be compounded with other existing active ingredients to screen for compound combinations that have synergistic effects on the target, which can not only improve the control effect and reduce the risk of drug resistance, but also effectively solve the problem of excessive pesticide residues. Summary of the invention

[0006] The object of the present invention is to provide a low-residue synergistic pesticide composition to solve the problems of long-term and large-scale use of clofoxanil as a single active ingredient, resulting in the risk of pesticide resistance, excessive pesticide residues and reduced control effects.

[0007] The present invention is achieved through the following technical solutions:

[0008] A low-residue synergistic pesticide composition comprises an active component a and an active component b; the active component a is fluazifop, and the active component b is triflupyrad or silthiopyrad.

[0009] Preferably, when the active component b is trifluopyridine, the mass ratio of the active component a to the active component b is 1-10:15-1.

[0010] Preferably, when the active component b is silthiopyrad, the mass ratio of the active component a to the active component b is 1-12:8-1.

[0011] Another object of the present invention is to provide a low-residue synergistic pesticide preparation, which contains 0.01-80% by weight of the low-residue synergistic pesticide composition, and the remainder is a pesticide-acceptable carrier and adjuvant. Wherein, the carrier can be selected from one or more of solid carriers and liquid carriers as needed, and the solid carrier is selected from one or more of mineral, plant, synthetic filler and inorganic salt carriers; the liquid carrier is selected from water and organic solvents. In addition, the adjuvant can be selected from one or more of surfactants, defoamers, thickeners and preservatives as needed, and can also be selected from other adjuvants commonly used in the art as needed.

[0012] Preferably, the low-residue synergistic pesticide preparation contains 0.05-60% by weight of the low-residue synergistic pesticide composition.

[0013] Preferably, the low-residue synergistic pesticide preparation contains 3-45% by weight of the low-residue synergistic pesticide composition.

[0014] Compared with the prior art, the present invention has the following beneficial effects:

[0015] Compared with the use of clofopyralid, triflupyralid or silthiopyrad alone, the pesticide composition of the present invention has the following advantages: it has a synergistic effect on plant diseases, can reduce the use dosage of the pesticide composition, reduce the prevention and control costs, pesticide residues and reduce environmental pressure; in addition, the present invention utilizes two active components with different action modes and different action mechanisms on plant diseases to carry out reasonable compounding, can delay the development of disease resistance and prolong the service life of the active components. DETAILED DESCRIPTION

[0016] The technical solution of the present invention is further described in detail below in conjunction with specific embodiments.

[0017] 1. Biologically active examples

[0018] 1.1 Test strains

[0019] Wheat fusarium graminearum, a fungus that causes wheat fusarium, was isolated from infected wheat plants and stored on PDA medium.

[0020] 2. Test reagents

[0021] 98% chlorpyrifos technical (Shandong Weifang Runfeng Chemical Co., Ltd.), 86% triflupyridam technical (Syngenta Crop Protection Co., Ltd., Switzerland), 98% silthiopyrad technical (Hebei Xingbai Agricultural Technology Co., Ltd.)

[0022] 3. Test methods

[0023] The mycelium growth rate method was used. The drug solution was prepared as follows: the test agent was dissolved in dimethyl sulfoxide and then diluted with a 0.1% Tween-80 aqueous solution to form a single-dose mother solution; multiple groups of ratios were set, and each single-dose mother solution and the ratio mixture were set to 5 mass concentration gradients according to the equal ratio method for standby use. Then 1.5mL of the drug solution and 10mL of PDA culture medium (pre-thawed and cooled to 50-55°C) were mixed evenly and poured into a culture dish with a diameter of 9cm. After cooling, a drug-containing plate was formed; 1.5mL of 0.1% Tween-80 aqueous solution and 10mL of PDA culture medium were mixed and poured into a culture dish with a diameter of 9cm to form a drug-free plate as a blank control. Each treatment was repeated 3 times, and each repeat had 3 plates.

[0024] Before inoculation, inoculate the test strain on PDA medium and culture at 25℃ for 3 days. Use a hole puncher to punch a 6mm diameter bacterial cake on the edge of the cultured colony, and inoculate the bacterial cake in the center of the drug-containing plate and the drug-free plate, with one bacterial cake inoculated on each plate. Cover the dish with a lid and continue to culture in an incubator at 25℃. When the colony diameter of the blank control grows to about 6cm, measure the colony diameter. Use the cross method to measure the diameter of each colony vertically once, take the average value, and calculate the mycelium growth inhibition rate.

[0025]

[0026] 4. Data Analysis and Efficacy Evaluation

[0027] The logarithmic value of the concentration of the drug and the probability value of the mycelium growth inhibition rate were used for regression analysis to calculate the toxicity EC of the drug to the test strain. 50 The co-toxicity coefficient CTC was calculated using the Sun Yunpei method, and the synergistic effect of the agent was evaluated based on the calculated co-toxicity coefficient CTC: CTC ≥ 120 was a synergistic effect, CTC ≤ 80 was an antagonistic effect, and 80 < CTC < 120 was an additive effect. The results are shown in Table 1-2.

[0028] 1. The biological activity results of fluazifop-trifluoroacetic acid combined with triflupyrazone against wheat fusarium graminearum

[0029]

[0030] It can be seen from the test results in Table 1 that within the mass ratio range of 1-10:15-1, the co-toxicity coefficient of clofopyralid and triflupyridamole to the wheat fusarium graminearum pathogen was greater than 120, showing a synergistic effect.

[0031] Table 2 The biological activity results of the combination of chlorfluanid and silthiopyrad against wheat fusarium graminearum

[0032]

[0033]

[0034] It can be seen from the test results in Table 1 that within the mass ratio range of 1-12:8-1, the co-toxicity coefficient of clofopyralid and silthiopyrad to the wheat fusarium graminearum pathogen was greater than 120, showing a synergistic effect.

[0035] In summary, compared with the use of clofopyralid, triflupyralid or silthiopyrad alone, the pesticide composition of the present invention has the following advantages: it has a synergistic effect on plant diseases, can reduce the dosage of the pesticide composition, reduce the prevention and control costs, pesticide residues and reduce environmental pressure; in addition, the present invention utilizes two active components with different modes of action and different mechanisms of action on plant diseases to reasonably compound, which can delay the development of disease resistance and extend the service life of the active components.

[0036] The low-residue synergistic pesticide composition of the present invention has been described through specific examples. Those skilled in the art can refer to the content of the present invention and appropriately change the raw materials, process conditions and other links to achieve corresponding other purposes. The relevant changes do not deviate from the content of the present invention. All similar replacements and modifications are obvious to those skilled in the art and are deemed to be included in the scope of the present invention.

Claims

1. A low-residue synergistic pesticide composition, characterized in that: The low-residue synergistic pesticide composition comprises an active component a and an active component b; the active component a is fluazifop, and the active component b is triflupyrad or silthiopyrad.

2. The low-residue synergistic pesticide composition according to claim 1, characterized in that: When the active component b is trifluopyridine, the mass ratio of the active component a to the active component b is 1-10:15-1.

3. The low-residue synergistic pesticide composition according to claim 1, characterized in that: When the active component b is silthiopyrad, the mass ratio of the active component a to the active component b is 1-12:8-1.

4. A low-residue synergistic pesticide formulation, characterized in that: The low-residue synergistic pesticide preparation contains 0.01-80% by weight of the low-residue synergistic pesticide composition according to any one of claims 1 to 3, and the remainder is a pesticide-acceptable carrier and adjuvant.

5. The low-residue synergistic pesticide formulation according to claim 4, characterized in that: The low-residue synergistic pesticide preparation contains 0.05-60% by weight of the low-residue synergistic pesticide composition according to any one of claims 1 to 3.

6. The low-residue synergistic pesticide formulation according to claim 4, characterized in that: The low-residue synergistic pesticide preparation contains 3-45% by weight of the low-residue synergistic pesticide composition according to any one of claims 1 to 3.

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