Intracavity filling structure and conveying system

Abstract

The invention relates to an intracavity filling structure which is characterized in that a filling inner cavity is formed in a filling bag body, the filling inner cavity is used for being filled with embolism substances, screening meshes communicated with the filling inner cavity are formed in the surface of the filling bag body, and the screening meshes allow blood to flow into the filling inner cavity from the outside of the filling bag body and limit the embolism substances to be separated from the filling inner cavity from the filling bag body; the filling bag body is provided with a filling window communicated with the filling inner cavity, and the filling clamping opening is communicated with the filling window of the filling bag body and used for opening the filling window in the open state and closing the filling window in the closed state. The screening meshes in the filling bag body allow blood in the aneurysm to flow into the filling inner cavity from the outside of the filling bag body, so that the blood is in contact with embolism substances in the filling bag body, the contact range is enlarged, thrombus is accelerated to be formed in the filling bag body, and the blood embolism effect is improved. And the sieving meshes in the filling bag body can limit the embolism substance to be separated from the filling bag body from the filling inner cavity, and the embolism substance is limited in the filling bag body, so that ectopic embolism caused by the embolism substance is avoided.

Description

Technical Field

[0001] The present application relates to the field of medical device technology, and in particular to an intracavitary filling structure and a delivery system. Background Art

[0002] Compared with open repair, endovascular repair of aneurysms is less invasive, has shorter hospital stay, and has lower early morbidity and mortality rates. It is the main surgical method for treating aneurysms. Endovascular repair of aneurysms mainly involves inserting a covered stent into the aneurysm via the artery to isolate the blood flow in the aneurysm sac. However, the therapeutic advantages of endovascular repair of aneurysms will be lost due to the occurrence of type II endoleak, which will increase the incidence of tumor enlargement and rupture, the re-intervention rate, and the mortality rate. The main cause of type II endoleak is that after the endovascular repair of aneurysms, the blood in the arterial branches flows retrogradely into the aneurysm cavity between the covered stent and the arterial wall, so that the aneurysm cavity remains connected to the circulatory system.

[0003] Embolization is the main surgical method for type II endoleak, and its basic purpose is to completely remove the aneurysm cavity and all inflow and outflow vessels. For example, before the main stent graft is implanted, the branch arteries of the aneurysm sac are embolized. After the main stent graft is implanted, the aneurysm cavity is filled with special materials through a pre-placed catheter to seal the aneurysm cavity as much as possible to isolate it from the circulatory system. At present, the commonly used filling materials for embolization of the sac cavity during aneurysm endovascular repair include solid materials and liquid materials, such as coils, fibrin glue, α-butyl 2-cyanoacrylate (NBCA), thrombin, etc.

[0004] Although a variety of filling materials have been gradually used in clinical practice, the effect of interventional treatment for type II endoleak is not satisfactory. After the formed thrombus is reabsorbed by the body, it is easy to recanalize and recur. The re-intervention rate is relatively high, or ectopic embolism may occur. The operation is difficult, and the re-intervention of endoleak will also increase costs and radiation exposure. Therefore, the effectiveness and safety of type II endoleak treatment cannot be guaranteed. Summary of the invention

[0005] Based on this, it is necessary to provide an intracavitary filling structure and a delivery system to address at least one of the technical problems mentioned above.

[0006] The present application provides an intracavity filling structure, the intracavity filling structure comprising:

[0007] A filling balloon, wherein the filling balloon has a filling inner cavity inside, the filling balloon is provided with a filling window connected to the filling inner cavity, the filling inner cavity is used to fill the embolic material, and the surface of the filling balloon has sieve holes connected to the filling inner cavity, the sieve holes allow blood to flow into the filling inner cavity from the outside of the filling balloon, and restrict the embolic material from escaping from the filling inner cavity;

[0008] A filling clamp is arranged on the filling capsule, the filling clamp has an open state and a closed state, the filling clamp is connected to the filling window, and is used to open the filling window in the open state and close the filling window in the closed state.

[0009] In one embodiment, the pore size of the sieve mesh is between 100 μm and 1000 μm.

[0010] In one embodiment, the filling lumen is filled with one embolic substance or a plurality of different embolic substances.

[0011] In one embodiment, the filling clamp includes at least two interconnected closing clamps, a filling channel is formed between at least two of the closing clamps, the filling channel is connected to the filling window, at least one of the closing clamps has deformation ability, and can fit together with other closing clamps to close the filling channel in a non-stressed state, and open the filling channel by deformation in a stressed state.

[0012] In one embodiment, the filling clamp includes a first closing clamp and a second closing clamp, and the filling channel is formed between the first closing clamp and the second closing clamp. At least one of the first closing clamp and the second closing clamp has deformation ability, so that the first closing clamp and the second closing clamp can close the filling channel by fitting together under no-stress state, and open the filling channel by deformation under stress state. At least one of the first closing clamp and the second closing clamp is provided with a guide groove, which is connected to the filling channel and is used to guide the inner core tube into the filling channel.

[0013] In one embodiment, the first closing clamp has a first unit groove, the second closing clamp has a second unit groove, and the first unit groove and the second unit groove are combined to form the guide groove; and / or,

[0014] The guide groove is a truncated cone-shaped groove.

[0015] In one embodiment, at least a portion of the surface of the filling balloon is provided with a bioactive coating, and the bioactive coating is used to promote endothelialization.

[0016] In one embodiment, the filling capsule is in the shape of a sphere, a cylinder, a hemisphere, a polyhedron, a prolate spheroid, and an oblate spheroid; and / or,

[0017] The material of the filling capsule is at least one of stainless steel, nitinol, cobalt-chromium alloy, polytetrafluoroethylene, lactic acid-glycolic acid copolymer, polycaprolactone, polyethylene terephthalate, chitosan and cellulose; and / or,

[0018] The filling clamp is made of metal material or rubber material; and / or,

[0019] The embolic material is at least one of a spring coil, a liquid embolic agent, a sponge embolic particle and a microsphere.

[0020] The present application provides a delivery system, the delivery system comprising:

[0021] An outer sheath tube, wherein the outer sheath tube has an axially penetrating sheath tube inner cavity;

[0022] An inner catheter, the inner catheter is movably mounted in the inner cavity of the sheath tube, and the inner catheter has an axially penetrating catheter cavity;

[0023] An inner core tube, the inner core tube is movably mounted in the catheter lumen, and the inner core tube has an axially penetrating core tube lumen;

[0024] The intracavity filling structure, the inner core tube is used to deliver the embolic material to the filling inner cavity of the intracavity filling structure.

[0025] In one embodiment, the delivery system comprises:

[0026] A developing element is disposed on at least one of the inner core tube and the cavity filling structure.

[0027] In the above-mentioned intracavity filling structure and delivery system, the sieve mesh holes on the filling capsule allow the blood in the aneurysm to flow into the filling cavity from the outside of the filling capsule, so that the blood and the embolic material in the filling capsule come into contact with each other, increase the contact range, and accelerate the formation of thrombus in the filling capsule. At the same time, the sieve mesh holes on the filling capsule will limit the embolic material from escaping from the filling cavity, confine the embolic material in the filling capsule, and avoid ectopic embolism that may be caused by the embolic material. When the aneurysm cavity is completely embolized by the filling capsule, the thrombus formed in the filling capsule based on the embolic material can be reabsorbed by the body, and the sieve mesh holes of the filling capsule allow the endothelial cells in the aneurysm vessel wall and the blood to pass through, grow inward, and proliferate by attaching to the filling capsule, promoting the re-endothelialization of the aneurysm cavity. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 A schematic diagram of the structure of an intracavitary filling structure filling an aneurysm provided in one embodiment of the present application.

[0029] Figure 2 A schematic diagram of the structure of multiple intracavitary filling structures filled in an aneurysm provided in one embodiment of the present application.

[0030] Figure 3 A schematic diagram of the structure of a conveying system provided in one embodiment of the present application.

[0031] Figure 4 A schematic diagram of the open state of a filling clamp provided in one embodiment of the present application.

[0032] Figure 5 A schematic diagram of a closed state of a filling clamp provided in one embodiment of the present application.

[0033] Figure 6 A schematic structural diagram of a guide groove provided in one embodiment of the present application.

[0034] Figure 7 A side view of a guide groove provided in accordance with an embodiment of the present application.

[0035] Figure Number:

[0036] 100, arterial blood vessels; 200, aneurysm;

[0037] 1000, filling capsule; 2000, embolic material; 3000, filling clamp; 4000, outer sheath; 5000, inner catheter; 6000, inner core tube;

[0038] 3100a, first closed-end clamp; 3100b, second closed-end clamp; 3100c, filling channel;

[0039] 3200, guide groove; 3200a, first unit groove; 3200b, second unit groove. DETAILED DESCRIPTION

[0040] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are described in detail below in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present application. However, the present application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present application, so the present application is not limited by the specific embodiments disclosed below.

[0041] In the description of the present application, it should be understood that if the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. appear, the orientation or position relationship indicated by these terms is based on the orientation or position relationship shown in the accompanying drawings, which is only for the convenience of describing the present application and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present application.

[0042] In addition, if the terms "first" or "second" appear, these terms are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include at least one of the features. In the description of this application, if the term "plurality" appears, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0043] In this application, unless otherwise clearly specified and limited, if the terms "installed", "connected", "connected", "fixed" and the like appear, these terms should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integrated connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to the specific circumstances.

[0044] In the present application, unless otherwise clearly specified and limited, if there is a description that a first feature is "above" or "below" a second feature, etc., or similar descriptions appear, it may mean that the first and second features are in direct contact, or that the first and second features are in indirect contact through an intermediate medium. Moreover, the first feature being "above", "above" and "above" the second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. The first feature being "below", "below" and "below" the second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0045] It should be noted that if an element is referred to as being "fixed to" or "disposed on" another element, it may be directly on the other element or there may be a central element. If an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. If any, the terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used in this application are for illustrative purposes only and do not represent the only implementation method.

[0046] See also Figures 1 to 5 As shown, an intracavity filling structure provided by an embodiment of the present application includes a filling capsule 1000 and a filling clamp 3000. The filling capsule 1000 has a filling inner cavity inside, and the filling inner cavity is used to fill the embolic material 2000. The surface of the filling capsule 1000 has sieve holes connected to the filling inner cavity. The sieve holes allow blood to flow into the filling inner cavity from the outside of the filling capsule 1000, and restrict the embolic material 2000 from escaping from the filling inner cavity to the filling capsule 1000. The filling clamp 3000 has an open state and a closed state. The filling clamp 3000 is configured to be in a closed state when not under force. The filling capsule 1000 has a filling window connected to the filling inner cavity. The filling clamp 3000 is connected to the filling window of the filling capsule 1000, and is used to open the filling window in the open state, and close the filling window in the closed state.

[0047] The filling balloon 1000 can be of various structures, shapes, materials, etc., so that the filling balloon 1000 can have high softness, conform to the aneurysm 200 cavity on the arterial blood vessel 100, and achieve effective embolization. According to the shape and size of the aneurysm cavity, one or more filling balloons 1000 can be inserted to achieve a better filling effect.

[0048] For example, the shape of the filling capsule 1000 can be selected to be one of a sphere, a cylinder, a hemisphere, a polyhedron, a prolate spheroid and an oblate spheroid. The material for making the filling capsule 1000 can be selected to be a material with good biocompatibility, or a biodegradable material, for example, the material for making the filling capsule 1000 is at least one of stainless steel, nitinol, cobalt-chromium alloy, polytetrafluoroethylene, lactic acid-glycolic acid copolymer, polycaprolactone, polyethylene terephthalate, chitosan and cellulose. Based on various manufacturing materials, the filling capsule 1000 can be made by a molding process such as template method, freeze drying, electrospinning, etc., or by a weaving, knitting or non-woven process, so that the filling capsule 1000 can be formed into a highly soft filling capsule 1000 with a sieve mesh.

[0049] The intracavitary filling structure can be delivered to a target location using an adapted delivery system, such as the aneurysm cavity of the aneurysm 200. Figure 3 As shown, the delivery system may generally include an outer sheath tube 4000, an inner catheter 5000, and an inner core tube 6000. The outer sheath tube 4000 has an axially through sheath tube lumen, which can be used to accommodate the filling balloon 1000 and deliver the filling balloon 1000 to the target position. The inner catheter 5000 is movably assembled in the sheath tube lumen, and the inner catheter 5000 has an axially through catheter lumen. The inner core tube 6000 is movably assembled in the catheter lumen, and the inner core tube 6000 has an axially through core tube lumen. The inner core tube 6000 is used to deliver embolic material 2000 to the filling lumen of the filling balloon 1000. The embolic material 2000 can promote thrombus formation in the filling balloon 1000.

[0050] When the inner core tube 6000 delivers the embolic material 2000, it will penetrate the filling clamp 3000. By applying a force to the filling clamp 3000, the filling clamp 3000 is in an open state due to the force, and the filling window is opened. The inner core tube 6000 then delivers the embolic material 2000 to the filling capsule 1000 through the filling window. After the filling is completed, the inner core tube 6000 is withdrawn, and the inner catheter 5000 can be used to resist the filling capsule 1000, so that the inner core tube 6000 is separated from the filling capsule 1000, and the outer sheath tube 4000, the inner catheter 5000 and the inner core tube 6000 are withdrawn, leaving the filling capsule 1000 at the target position. At this time, the inner core tube 6000 no longer applies a force to the filling clamp 3000, so that the filling clamp 3000 is in a non-stressed state, and the filling clamp 3000 automatically changes from an open state to a closed state.

[0051] The sieve mesh holes on the filling capsule 1000 allow the blood in the aneurysm 200 to flow from the outside of the filling capsule 1000 into the filling inner cavity, so that the blood and the embolic material 2000 in the filling capsule 1000 come into contact with each other, increase the contact range, and accelerate the formation of thrombus in the filling capsule 1000. At the same time, the sieve mesh holes on the filling capsule 1000 will limit the embolic material 2000 from escaping from the filling inner cavity, confine the embolic material 2000 in the filling capsule 1000, and avoid ectopic embolism that may be caused by the embolic material 2000 escaping. When the aneurysm cavity is completely embolized by the filling capsule 1000, the thrombus formed in the filling capsule 1000 based on the embolic material 2000 can be reabsorbed by the body, and the sieve mesh holes of the filling capsule 1000 allow the endothelial cells in the aneurysm 200 vessel wall and blood to pass through, adhere to the filling capsule 1000 to proliferate and grow inward, and promote the re-endothelialization of the aneurysm cavity.

[0052] The self-closing function of the filling sac 1000 in the closed state by the filling clamp 3000 in the unstressed state can limit the position of the embolic material 2000 after filling the embolic material 2000, so that the embolic position is controllable and will not cause ectopic embolism. The filling sac 1000 can allow multiple embolic materials 2000 to be filled at the same time, which can promote thrombosis in the aneurysm cavity to a certain extent. Moreover, the filling sac 1000 can improve the degree of re-endothelialization in the aneurysm cavity, promote the recovery in the aneurysm cavity, and simulate the natural function of the vascular system. The thrombus formed in the early stage of the filling sac 1000 and the filling sac 1000 after surface endothelialization can reduce the pressure of the isolated aneurysm 200, reduce the volume of the aneurysm, avoid the serious consequences of the enlargement and rupture of the abdominal aortic aneurysm 200, and significantly reduce the incidence of type II internal leakage and the re-intervention rate. At least a part of the surface of the filling sac 1000 can also be provided with a bioactive coating, and the bioactive coating is used to promote endothelialization and thrombosis. For example, thrombin can be selected for the bioactive coating.

[0053] The aperture of the sieve mesh can be determined according to the size of the embolic material 2000 filled in the filling capsule 1000, so that the aperture of the sieve mesh can satisfy both the flow of blood and the isolation of the embolic material 2000. For example, in one embodiment, the aperture of the sieve mesh can be set between 100 μm and 1000 μm. The aperture of 100 μm to 1000 μm will neither cause the embolic material 2000 to leak out of the filling capsule 1000 nor cause thrombus formation and blockage on the surface of the filling capsule 1000 due to too small aperture. For example, when the embolic material 2000 is selected as gelatin sponge particles with a particle size range of 350 μm to 560 μm, the sieve mesh with an aperture of 100 μm to 300 μm can be selected.

[0054] For other types of embolic substances 2000, the aperture of the sieve mesh can be selected as 100μm, 150μm, 200μm, 250μm, 300μm, 350μm, 400μm, 450μm, 500μm, 550μm, 600μm, 650μm, 700μm, 750μm, 800μm, 850μm, 900μm, 950μm, 1000μm and other different apertures, and those skilled in the art can choose according to actual needs, which is not limited here. Moreover, the type of embolic substance 2000 filled in the filling capsule 1000 can be only one, or multiple types can be selected to be filled in one filling capsule 1000 at the same time. The embolic substance 2000 includes but is not limited to spring coils, liquid embolic agents, sponge embolic particles, microspheres, etc. Therefore, the aperture of the sieve mesh on the filling capsule 1000 can also be adapted according to the size range of the various embolic substances 2000 filled therein, which is not limited here.

[0055] The filling clamp 3000 can be in various structures, as long as it meets the requirements of conveying the embolic material 2000 and has a self-closing function in a closed state when not under stress, so as to limit the position of the embolic material 2000. For example, in one embodiment, the filling clamp 3000 includes two or more closed clamps connected to each other, and the space formed between the closed clamps constitutes a filling channel 3100c, and the filling channel 3100c is connected to the filling window. At least one closed clamp has a deformation ability, and can close the filling channel 3100c by fitting with other closed clamps in a non-stressed state, and open the filling channel 3100c by deformation in a stressed state, so as to realize the conversion of the filling clamp 3000 between the open state and the closed state.

[0056] The filling clamp 3000 is made of metal material or rubber material, for example, the closing clamp is made of metal strips such as nickel-titanium alloy, stainless steel, etc., or rubber bands, springs, etc. with self-tightening function, so that the entire filling clamp 3000 is in a closed state when there is no external force. Those skilled in the art can select appropriate materials to construct the self-closing function of the filling clamp 3000 according to needs, and this is not limited here.

[0057] See also Figure 4 and Figure 5As shown, in one embodiment, the filling clamp 3000 includes two closing clamps, namely a first closing clamp 3100a and a second closing clamp 3100b, and a filling channel 3100c is formed between the first closing clamp 3100a and the second closing clamp 3100b, and at least one of the first closing clamp 3100a and the second closing clamp 3100b has deformation ability, so that the first closing clamp 3100a and the second closing clamp 3100b can close the filling channel 3100c by fitting together in a non-stressed state, and open the filling channel 3100c by deformation in a stressed state. The inner core tube 6000 can be embedded in the filling channel 3100c to deliver various embolic substances 2000 into the filling capsule 1000. After the embolic substances 2000 are delivered, the inner core tube 6000 is withdrawn, and the first closing clamp 3100a and the second closing clamp 3100b are pressed against each other to automatically close the filling channel 3100c, thereby closing the filling window of the filling capsule 1000.

[0058] See also Figure 6 and Figure 7 As shown, at least one of the first closed clamp 3100a and the second closed clamp 3100b may also be provided with a guide groove 3200, the guide groove 3200 is communicated with the filling channel 3100c, and the construction of the guide groove 3200 can be used to guide the inner core tube 6000 into the filling channel 3100c, so the shape of the guide groove 3200 can be constructed as a truncated cone-shaped groove or other shape suitable for guiding the inner core tube 6000 to penetrate into the filling channel 3100c. In one embodiment, the first closed clamp 3100a is provided with a first unit groove 3200a, and the second closed clamp 3100b is provided with a second unit groove 3200b, and the first unit groove 3200a and the second unit groove 3200b are combined to form the guide groove 3200. In addition, the guide groove 3200 can also be provided only on the first closed clamp 3100a or the second closed clamp 3100b. Those skilled in the art can construct it according to actual needs, and it is not limited here.

[0059] The present application provides a delivery system, which includes an outer sheath tube 4000, an inner catheter 5000, an inner core tube 6000 and an intracavity filling structure, wherein the outer sheath tube 4000 has an axially penetrating sheath tube lumen, the inner catheter 5000 is movably assembled in the sheath tube lumen, the inner catheter 5000 has an axially penetrating catheter lumen, the inner core tube 6000 is movably assembled in the catheter lumen, the inner core tube 6000 has an axially penetrating core tube lumen, and the inner core tube 6000 is used to deliver embolic material 2000 to the filling lumen of the intracavity filling structure. Since the specific structure and functional principle of the above-mentioned intracavity filling structure are described in detail above, they will not be repeated here.

[0060] In one embodiment, the delivery system includes a developing element. The developing element can be constructed of a radiopaque material, such as dense metals such as tungsten and bismuth. The developing element can be set at an appropriate position on the inner core tube 6000 or the intracavitary filling structure according to the requirements for identifying the advancement position of the filling capsule 1000. For example, the developing element is set on the inner core tube 6000 and is located at a position on the inner core tube 6000 for contacting a specific position on the intracavitary filling structure. The specific position can be a position where the filling capsule 1000 is easily identified. For example, the contact position between the inner core tube 6000 and the filling clamp 3000 of the intracavitary filling structure is easy to identify. Therefore, it can be selected to be set at a position on the inner core tube 6000 for contacting the filling clamp 3000. When the filling capsule 1000 is advanced through the inner core tube 6000, the developing element can enable the operator to visualize the position of the filling capsule 1000, thereby facilitating the operation.

[0061] The technical features of the above embodiments may be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0062] The above-described embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be construed as limiting the scope of the patent application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent application shall be subject to the attached claims.

Claims

1. A cavity filling structure, characterized in that: The intracavity filling structure comprises: A filling balloon, wherein the filling balloon has a filling inner cavity inside, the filling balloon is provided with a filling window connected to the filling inner cavity, the filling inner cavity is used to fill the embolic material, and the surface of the filling balloon has sieve holes connected to the filling inner cavity, the sieve holes allow blood to flow into the filling inner cavity from the outside of the filling balloon, and restrict the embolic material from escaping from the filling inner cavity; A filling clamp is arranged on the filling capsule, the filling clamp has an open state and a closed state, the filling clamp is connected to the filling window, and is used to open the filling window in the open state and close the filling window in the closed state.

2. The intracavity filling structure according to claim 1, characterized in that: The pore size of the sieve mesh is between 100 μm and 1000 μm.

3. The intracavity filling structure according to claim 1, characterized in that: The filling inner cavity is filled with one embolic substance or a plurality of different embolic substances.

4. The intracavity filling structure according to claim 1, characterized in that: The filling clamp includes at least two mutually connected closing clamps, a filling channel is formed between at least two of the closing clamps, and the filling channel is connected to the filling window. At least one of the closing clamps has the ability to deform, and can fit together with other closing clamps to close the filling channel in a non-stressed state, and open the filling channel by deformation in a stressed state.

5. The intracavity filling structure according to claim 4, characterized in that: The filling clamp includes a first closing clamp and a second closing clamp, and the filling channel is formed between the first closing clamp and the second closing clamp. At least one of the first closing clamp and the second closing clamp has deformation ability, so that the first closing clamp and the second closing clamp can close the filling channel by fitting together under no-stress state, and open the filling channel by deformation under stress state. At least one of the first closing clamp and the second closing clamp is provided with a guide groove, which is connected to the filling channel and is used to guide the inner core tube into the filling channel.

6. The intracavity filling structure according to claim 5, characterized in that: The first closing clamp has a first unit groove, the second closing clamp has a second unit groove, and the first unit groove and the second unit groove are combined to form the guide groove; and / or, The guide groove is a truncated cone-shaped groove.

7. The intracavity filling structure according to claim 1, characterized in that: A bioactive coating is disposed on at least a portion of the surface of the filling balloon, and the bioactive coating is used to promote endothelialization.

8. The intracavity filling structure according to claim 1, characterized in that: The shape of the filling capsule is one of a sphere, a cylinder, a hemisphere, a polyhedron, a prolate spheroid and an oblate spheroid; and / or, The material of the filling capsule is at least one of stainless steel, nitinol, cobalt-chromium alloy, polytetrafluoroethylene, lactic acid-glycolic acid copolymer, polycaprolactone, polyethylene terephthalate, chitosan and cellulose; and / or, The filling clamp is made of metal material or rubber material; and / or, The embolic material is at least one of a spring coil, a liquid embolic agent, a sponge embolic particle and a microsphere.

9. A conveying system, characterized in that: The delivery system comprises: An outer sheath tube, wherein the outer sheath tube has an axially penetrating sheath tube inner cavity; An inner catheter, the inner catheter is movably mounted in the inner cavity of the sheath tube, and the inner catheter has an axially penetrating catheter cavity; An inner core tube, the inner core tube is movably mounted in the catheter lumen, and the inner core tube has an axially penetrating core tube lumen; The intracavitary filling structure according to any one of claims 1 to 8, wherein the inner core tube is used to deliver the embolic material to the filling lumen of the intracavitary filling structure.

10. The conveying system according to claim 9, characterized in that The delivery system comprises: A developing element is disposed on at least one of the inner core tube and the cavity filling structure.

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