Galactose modified liver targeting mesoporous silica material, preparation method and application

The mesoporous silica material prepared and modified by hydrothermal synthesis, combined with graphene quantum dots and PEG chains, solved the problem of short retention time in the prior art of leech active peptide GA-10 in vivo and short maintenance time in liver aggregation, realizing the functions of liver targeted delivery and redox response release, enhancing the stability of the drug and liver maintenance time.

CN119701007APending Publication Date: 2025-03-28BINZHOU MEDICAL COLLEGE
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Patent Information

Application Number
CN202411839428.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-13
Publication Date
2025-03-28

AI Technical Summary

Technical Problem

The prior art lacks the problem of studying graphene quantum dot coverage and galactose-modified liver-targeted mesoporous silica materials and drug-carrying systems for redox response release in vivo, resulting in the short retention time of leech active peptide GA-10 in vivo and short maintenance time of liver aggregation.

Method used

Mesoporous silica was prepared by hydrothermal synthesis, and the graphene quantum dots and PEG chain galactose modification was prepared with graphene quantum dot covering and galactose modification with redox response release function.

Benefits of technology

The redox response release under certain concentrations of glutathione enrichment conditions in vivo is achieved, which enhances the liver targeted delivery ability of the leech active peptide GA-10 and the stability of the drug, and extends the maintenance time of the drug in the liver.

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Abstract

The invention belongs to the field of biological medicine, and particularly relates to a galactose modified liver targeting mesoporous silica material, a preparation method and application. Mesoporous silica is prepared through a hydrothermal synthesis method, modification is carried out through amino, disulfide bonds, graphene quantum dots and amino-terminated PEG chain galactose, a multifunctional drug carrier (PEG-Gal-MSNs-SS-GQDs) with the redox response release function is prepared, meanwhile, leech active peptide GFAGDDAPRA (GA-10) is loaded into a mesoporous channel, liver targeting release of drugs is achieved, and the liver targeting effect is achieved. The material loaded with the GA-10 has good redox response release characteristics and blood fat reducing activity. The PEG-Gal-MSN-SS-GQDs disclosed by the invention have a wide application prospect, and a new thought is provided for research on application of mesoporous silica in peptide drug loading and blood fat reduction.
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