Storage device capable of releasing gas hydrogel and use method

Abstract

The invention relates to the field of medical apparatus and instruments, and discloses a storage device capable of releasing gas hydrogel and a use method of the storage device. The storage device comprises a gas storage unit; a hydrogel storage unit; the communicating unit comprises a communicating pipe, the two ends of the communicating pipe communicate with the gas storage unit and the hydrogel storage unit correspondingly, the communicating pipe is provided with a blocking valve, and when the blocking valve is closed, the communicating pipe is divided into two parts communicating with the gas storage unit and communicating with the hydrogel storage unit; the communicating pipe, and / or the joint of the communicating pipe and the gas storage unit, and / or the joint of the communicating pipe and the hydrogel storage unit are arranged in a breakable manner. The storage device is easy to prepare, low in cost and simple and rapid in use method, gas molecules can be directly released, the local gas concentration of the wound surface can be increased, oxidation reduction and other chemical processes and microsphere packaging and other processes are not needed, the physicochemical properties of hydrogel are not changed, the storage device can be combined with existing dressing for use, and the application range is wide. The method is more suitable for improving the performance of the existing hydrogel product.

Description

Technical Field

[0001] The present application relates to the field of medical device technology, and more specifically, to a storage device and a method for using a gas-releasing hydrogel. Background Art

[0002] In the field of wound treatment, hydrogel, as an efficient and multifunctional therapeutic preparation, has become one of the indispensable materials for promoting wound healing due to its excellent moisture retention, biocompatibility and drug loading capacity. In addition, gas components also play a vital role in the wound healing process, including oxygen, nitric oxide, hydrogen and other gases that promote wound healing. Therefore, hydrogels that can release gas are currently a hot research topic.

[0003] The gases that have been found to promote wound healing are difficult to dissolve directly in the hydrogel matrix. The existing technical paths mainly rely on gas metal salts, nano-microsphere encapsulation and other methods to achieve gas encapsulation and release. However, the above methods have many shortcomings such as incomplete gas release, high cost, and unstable physical and chemical properties, and are not widely used at present. In addition, the hydrogel prepared by the above method has a short storage time and is easy to decompose and become ineffective.

[0004] Therefore, in medical clinical work, there is still a lack of practical gas-releasing hydrogels, which limits their widespread application in medical clinical work. Summary of the invention

[0005] The purpose of the present invention is to develop a novel, efficient, stable and cost-controllable gas-releasing hydrogel preparation technology to meet the precise regulation of gas component requirements in wound treatment and promote the development of the wound healing field in response to the above-mentioned problems in the prior art, combined with the problems in medical clinical work and the phenomenon that wound treatment requires a large amount of hydrogel dressings.

[0006] In order to achieve the above invention objectives, this application adopts the following technical solutions:

[0007] In a first aspect, the present application provides a storage device for a gas-releasing hydrogel, comprising:

[0008] A gas storage unit for storing gas;

[0009] A hydrogel storage unit, used for storing hydrogel;

[0010] A communication unit, comprising a communication pipe, both ends of which are respectively connected to the gas storage unit and the hydrogel storage unit, and a blocking valve is provided in the communication pipe, and when the blocking valve is closed, the internal space of the communication pipe is divided into two independent parts connected to the gas storage unit and the hydrogel storage unit;

[0011] The connecting tube, and / or the connection between the connecting tube and the gas storage unit, and / or the connection between the connecting tube and the hydrogel storage unit can be broken.

[0012] Further, the gas storage unit comprises a first storage tube, a first piston and a first push rod;

[0013] One end of the first storage pipe is connected to the connecting pipe;

[0014] The first piston is movably disposed in the first storage tube;

[0015] The first push rod passes through one end of the first storage tube away from the connecting tube and is connected to the first piston, and is used to control the movement of the first piston in the first storage tube;

[0016] The gas is stored in a closed space which is formed by the first piston and the inner wall of the first storage tube and is close to the connecting tube.

[0017] Further, the hydrogel storage unit comprises a second storage tube, a second piston and a second push rod;

[0018] One end of the second storage pipe is connected to the connecting pipe;

[0019] The second piston is movably disposed in the second storage tube;

[0020] The second push rod passes through one end of the second storage tube away from the connecting tube and is connected to the second piston, and is used to control the movement of the second piston in the second storage tube;

[0021] The hydrogel is stored in a closed space which is formed by the second piston and the inner wall of the second storage tube and is close to the connecting tube.

[0022] In a second aspect, the present application provides a method for using the storage device for the gas-releasable hydrogel described in the first aspect, comprising the following steps:

[0023] Step 1: Open the isolation valve of the communication unit to connect the gas storage unit, the hydrogel storage unit and the communication unit;

[0024] Step 2: mixing the gas stored in the gas storage unit and the hydrogel stored in the hydrogel storage unit to form a foamed hydrogel;

[0025] Step 3: Disconnect the connecting tube, or the connection between the connecting tube and the gas storage unit, or the connection between the connecting tube and the hydrogel storage unit, and apply the foamed hydrogel to the wound surface.

[0026] Furthermore, in the storage device:

[0027] The gas storage unit comprises a first storage tube, a first piston and a first push rod; one end of the first storage tube is connected to the connecting tube;

[0028] The first piston is movably disposed in the first storage tube;

[0029] The first push rod passes through one end of the first storage tube away from the connecting tube and is connected to the first piston, and is used to control the movement of the first piston in the first storage tube;

[0030] The gas is stored in a closed space formed by the first piston and the inner wall of the first storage tube and close to the connecting tube;

[0031] The hydrogel storage unit comprises a second storage tube, a second piston and a second push rod;

[0032] One end of the second storage pipe is connected to the connecting pipe;

[0033] The second piston is movably disposed in the second storage tube;

[0034] The second push rod passes through one end of the second storage tube away from the connecting tube and is connected to the second piston, and is used to control the movement of the second piston in the second storage tube;

[0035] The hydrogel is stored in a closed space formed by the second piston and the inner wall of the second storage tube and close to the connecting tube;

[0036] The method of use comprises the following steps:

[0037] Step 1: Open the isolation valve of the communication unit to connect the gas storage unit, the hydrogel storage unit and the communication unit;

[0038] Step 2: repeatedly push and pull the first push rod and the second push rod, so that the first push rod and the second push rod move forward and backward in the same direction, so that the gas stored in the gas storage unit and the hydrogel stored in the hydrogel storage unit are mixed to form a foamed hydrogel;

[0039] Step 3: Disconnect the connecting tube, or the connection between the connecting tube and the gas storage unit, or the connection between the connecting tube and the hydrogel storage unit, and apply the foamed hydrogel to the wound surface.

[0040] In summary, this application has the following beneficial effects:

[0041] The gas-releasable hydrogel storage device of the present application is simple to prepare, low in cost, and simple and quick to use, can be used at home, and is suitable for chronic wounds that require long-term use.

[0042] The gas-releasable hydrogel storage device of the present application can directly release gas molecules to increase the local gas concentration on the wound surface without going through chemical processes such as oxidation-reduction and without processes such as microsphere packaging.

[0043] The gas-releasing hydrogel storage device of the present application does not change the physical and chemical properties of the hydrogel, can be used in combination with existing dressings, and is more suitable for improving the performance of existing hydrogel products. BRIEF DESCRIPTION OF THE DRAWINGS

[0044] Figure 1 : Schematic diagram of the structure of the storage device of the gas-releasing hydrogel in the embodiment of the present application.

[0045] Figure numerals: 10, gas storage unit; 11, first storage tube; 12, first piston; 13, first push rod; 20, hydrogel storage unit; 21, second storage tube; 22, second piston; 23, second push rod; 30, connecting unit; 31, connecting tube; 32, blocking valve. DETAILED DESCRIPTION

[0046] The structure and effect of the present application are further described in detail below in conjunction with the embodiments. It is to be understood that the specific embodiments described herein are only used to explain the invention, rather than to limit the invention. It should also be noted that, for ease of description, only the parts related to the invention, rather than all structures, are shown in the drawings.

[0047] Example 1

[0048] The present application embodiment discloses a storage device for releasing gas hydrogel, referring to Figure 1 The storage device includes a gas storage unit 10 for storing gas, a hydrogel storage unit 20 for storing hydrogel, and a communication unit 30.

[0049] The connecting unit 30 includes a connecting pipe 31 and a blocking valve 32. Both ends of the connecting pipe 31 are connected to the gas storage unit 10 and the hydrogel storage unit 20 respectively. The blocking valve 32 is arranged in the connecting pipe 31, preferably in the middle of the connecting pipe 31. When the blocking valve 32 is closed, the blocking valve 32 divides the internal space of the connecting pipe 31 into two independent parts (i.e., two parts that are not connected), one connected to the gas storage unit 10 and the other connected to the hydrogel storage unit 20; when the blocking valve 32 is opened, the above two independent parts are connected again.

[0050] The connecting tube 31, and / or the connection between the connecting tube 31 and the gas storage unit 10, and / or the connection between the connecting tube 31 and the hydrogel storage unit 20 can be broken. This breakable setting can be achieved by the material of the connecting tube 31. For example, the connecting tube 31 is made of an easy-to-break material, and when it needs to be broken, it only needs to be broken by the operator. It can also be assisted by a preset fracture mark, such as the fracture structure of an ampoule. In this embodiment, it is preferred to make a breakable setting at the connection between the connecting tube 31 and the gas storage unit 10 or at the connection between the connecting tube 31 and the hydrogel storage unit 20.

[0051] The gas storage unit 10 includes a first storage tube 11, a first piston 12 and a first push rod 13. One end of the first storage tube 11 is connected to the connecting tube 31. Specifically, a hole is provided at the center of the end of the first storage tube 11, and the end of the connecting tube 31 is connected to the hole. The first piston 12 is movably arranged in the first storage tube 11. The first push rod 13 passes through one end of the first storage tube 11 away from the connecting tube 31 and is connected to the first piston 12, and is used to control the movement of the first piston 12 in the first storage tube 11. The gas is stored in a closed space formed by the first piston 12 and the inner wall of the first storage tube 11 and close to the connecting tube 31.

[0052] The hydrogel storage unit 20 includes a second storage tube 21, a second piston 22, and a second push rod 23. One end of the second storage tube 21 is connected to the connecting tube 31. Specifically, it can be configured that a hole is provided at the center of the end of the second storage tube 21, and the end of the connecting tube 31 is connected to the hole. The second piston 22 is movably arranged in the second storage tube 21, and the second push rod 23 passes through one end of the second storage tube 21 away from the connecting tube 31 and is connected to the second piston 22, and is used to control the movement of the second piston 22 in the second storage tube 21. The gas is stored in a closed space formed by the second piston 22 and the inner wall of the second storage tube 21 and close to the connecting tube 31.

[0053] The method for using the gas-releasing hydrogel storage device comprises the following steps:

[0054] Step 1: Open the blocking valve 32 of the connecting unit 30 to connect the gas storage unit 10, the hydrogel storage unit 20 and the connecting unit 30;

[0055] Step 2: repeatedly push and pull the first push rod 13 and the second push rod 23, so that the first push rod 13 and the second push rod 23 move forward and backward in the same direction, so that the gas stored in the gas storage unit 10 and the hydrogel stored in the hydrogel storage unit 20 are mixed to form a foamed hydrogel;

[0056] Step 3: Disconnect the connecting tube 31, or the connection between the connecting tube 31 and the gas storage unit 10, or the connection between the connecting tube 31 and the hydrogel storage unit 20, and apply the foamed hydrogel to the wound surface. The bubbles burst to release gas, and the gas is blocked by the upper layer of hydrogel and cannot overflow, so it stays on the wound surface, which plays a role in promoting wound healing.

[0057] For chronic wounds that require long-term use, the gas-releasing hydrogel storage device can be used repeatedly.

[0058] It is worth noting that the ratio of gas to hydrogel can be adjusted according to clinical needs to meet the needs of different patients or different wound treatments.

[0059] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. A storage device for gas-releasing hydrogel, characterized in that: include: A gas storage unit for storing gas; A hydrogel storage unit, used for storing hydrogel; A communication unit, comprising a communication pipe, both ends of which are respectively connected to the gas storage unit and the hydrogel storage unit, and a blocking valve is provided in the communication pipe, and when the blocking valve is closed, the internal space of the communication pipe is divided into two independent parts connected to the gas storage unit and the hydrogel storage unit; The connecting tube, and / or the connection between the connecting tube and the gas storage unit, and / or the connection between the connecting tube and the hydrogel storage unit can be broken.

2. The gas-releasable hydrogel storage device according to claim 1, characterized in that: The gas storage unit comprises a first storage tube, a first piston and a first push rod; One end of the first storage pipe is connected to the connecting pipe; The first piston is movably disposed in the first storage tube; The first push rod passes through one end of the first storage tube away from the connecting tube and is connected to the first piston, and is used to control the movement of the first piston in the first storage tube; The gas is stored in a closed space which is formed by the first piston and the inner wall of the first storage tube and is close to the connecting tube.

3. The gas-releasable hydrogel storage device according to claim 1, characterized in that: The hydrogel storage unit comprises a second storage tube, a second piston and a second push rod; One end of the second storage pipe is connected to the connecting pipe; The second piston is movably disposed in the second storage tube; The second push rod passes through one end of the second storage tube away from the connecting tube and is connected to the second piston, and is used to control the movement of the second piston in the second storage tube; The hydrogel is stored in a closed space which is formed by the second piston and the inner wall of the second storage tube and is close to the connecting tube.

4. A method for using the gas-releasing hydrogel storage device according to any one of claims 1 to 3, characterized in that: The following steps are involved: Step 1: Open the isolation valve of the communication unit to connect the gas storage unit, the hydrogel storage unit and the communication unit; Step 2: mixing the gas stored in the gas storage unit and the hydrogel stored in the hydrogel storage unit to form a foamed hydrogel; Step 3: Disconnect the connecting tube, or the connection between the connecting tube and the gas storage unit, or the connection between the connecting tube and the hydrogel storage unit, and apply the foamed hydrogel to the wound surface.

5. The method of use according to claim 4, characterized in that: In the storage device: The gas storage unit comprises a first storage tube, a first piston and a first push rod; one end of the first storage tube is connected to the connecting tube; The first piston is movably disposed in the first storage tube; The first push rod passes through one end of the first storage tube away from the connecting tube and is connected to the first piston, and is used to control the movement of the first piston in the first storage tube; The gas is stored in a closed space formed by the first piston and the inner wall of the first storage tube and close to the connecting tube; The hydrogel storage unit comprises a second storage tube, a second piston and a second push rod; One end of the second storage pipe is connected to the connecting pipe; The second piston is movably disposed in the second storage tube; The second push rod passes through one end of the second storage tube away from the connecting tube and is connected to the second piston, and is used to control the movement of the second piston in the second storage tube; The hydrogel is stored in a closed space formed by the second piston and the inner wall of the second storage tube and close to the connecting tube; The method of use comprises the following steps: Step 1: Open the isolation valve of the communication unit to connect the gas storage unit, the hydrogel storage unit and the communication unit; Step 2: repeatedly push and pull the first push rod and the second push rod, so that the first push rod and the second push rod move forward and backward in the same direction, so that the gas stored in the gas storage unit and the hydrogel stored in the hydrogel storage unit are mixed to form a foamed hydrogel; Step 3: Disconnect the connecting tube, or the connection between the connecting tube and the gas storage unit, or the connection between the connecting tube and the hydrogel storage unit, and apply the foamed hydrogel to the wound surface.

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