Preparation device of tedizolid key intermediate

Abstract

The invention relates to the technical field of raw material medicine preparation, and discloses a tedizolid key intermediate preparation device which comprises a box body, a driving assembly is arranged outside the box body, a mixing assembly is arranged inside the box body, a heating assembly is arranged on the right side of the box body, and a discharging groove is formed in the right side of the box body. An inner cavity of the discharging groove is fixedly connected with a discharging hopper, and the mixing assembly comprises two reciprocating lead screws rotationally connected to the inner cavity of the box body through two bearings and a connecting rod rotationally connected to the left side of the box body through one bearing. Through mutual cooperation of the driving assembly and the mixing assembly, an operator can conveniently perform up-down reciprocating type and transverse type different multiple mixing work on tedizolid raw materials in the box body in a manner of reducing energy consumption, so that the phenomenon of incomplete mixing can be prevented; and the mixing effect of tedizolid raw materials during preparation of intermediates in the box body is effectively improved.

Description

Technical Field

[0001] The invention relates to the technical field of raw material drug preparation, in particular to a preparation device for a key intermediate of tedizolid. Background Art

[0002] Tedizolid phosphate is a new type of oxazolidinone antibiotic. In clinical trials, tedizolid phosphate showed higher activity against Staphylococcus aureus, methicillin-resistant bacteria, methicillin-sensitive bacteria and streptococci, which is 2-4 times that of linezolid. Compared with linezolid, tedizolid phosphate has other advantages: clinical trials have found that tedizolid phosphate has fewer gastrointestinal side effects; no drug interactions similar to linezolid have occurred.

[0003] When preparing tedizolid, complete mixing and reaction are required. However, in the current preparation process of the key intermediate of tedizolid phosphate, the raw materials of tedizolid are only mixed in a relatively simple manner, and the raw materials of tedizolid cannot be mixed multiple and differently. As a result, in actual use, the mixing is incomplete and uneven and the preparation rate is slow. Summary of the invention

[0004] In view of the deficiencies in the prior art, the present invention provides a device for preparing a key intermediate of tedizolid, which solves the above-mentioned problems.

[0005] The present invention provides the following technical solution: a preparation device for a key intermediate of tedizolid, comprising a box, a driving assembly is arranged outside the box, a mixing assembly is arranged inside the box, a heating assembly is arranged on the right side of the box, a discharge trough is opened on the right side of the box, and a discharge hopper is fixedly connected to the inner cavity of the discharge trough;

[0006] The mixing assembly comprises two reciprocating screws rotatably connected to the inner cavity of the housing through two bearings and a connecting rod rotatably connected to the left side of the housing through a bearing, the outer rings of the two reciprocating screws are both equipped with a first pulley, the middle parts of the two reciprocating screws are both equipped with a gear, the outer rings of the two reciprocating screws located inside the housing are both equipped with a threaded sleeve, the tops of the two threaded sleeves are penetrated with screw holes that are compatible with the reciprocating screws, the outer rings of the two threaded sleeves are provided with a plurality of stirring blades, the left side of the connecting rod penetrates the housing and is fixedly connected to the first bevel gear, and the outer ring of the connecting rod is fixedly connected to an auger;

[0007] The driving assembly includes a connecting frame fixedly connected to the outside of the box body, a servo motor is arranged on the top of the connecting frame, a rotating rod is sleeved on the output end of the servo motor through a coupling, and a second pulley is sleeved on the outer ring of the rotating rod.

[0008] Preferably, a mixing sheet is fixedly connected between every two of the staggered stirring blades, and the mixing sheets are all arranged in an inclined shape.

[0009] Preferably, the outer ring size of the auger is larger than the inner wall size of the discharge chute.

[0010] Preferably, the second pulley is movably sleeved with a first belt on the outer ring of the first pulley on the left side, and the bottom of the rotating rod is fixedly connected with a second bevel gear.

[0011] Preferably, the second bevel gear is meshingly connected with the first bevel gear.

[0012] Preferably, the bottoms of the two reciprocating screw rods are fixedly connected to limit rings, and the two limit rings are not in contact with the auger and are separated by a distance that is the same as the inner wall of the discharge trough.

[0013] Preferably, the heating assembly comprises a heating device fixedly connected to the right side of the box body, the right side of the heating device is fixedly connected to an exhaust fan, the air inlet of the exhaust fan is fixedly connected to a filter screen, an air pipe is sleeved between the exhaust fan and the heating device, a plurality of heating rods are arranged inside the heating device, a control panel is arranged on the front of the heating device, a suction dual-purpose pump is arranged on the top of the heating device, a double-way pipe is arranged on the top of the suction dual-purpose pump, a first connecting pipe and a second connecting pipe are respectively sleeved on both sides of the double-way pipe and the top and the front of the box body, a first cross pipe and a second cross pipe are respectively sleeved between the first connecting pipe and the second connecting pipe and the heating device, a sealed bearing is arranged in the inner cavity of the first connecting pipe, the inner cavity of the first connecting pipe is rotatably connected to the air pipe through the sealed bearing, a third pulley is sleeved on the outer ring of the air pipe, a jet disk is sleeved on the bottom of the air pipe, and a second belt is movably sleeved on the outer ring of the third pulley and the first pulley on the right side.

[0014] Preferably, valves are provided on the tops of the first connecting pipe and the second connecting pipe, and the control panel is electrically connected to the plurality of heating rods.

[0015] Compared with the prior art, the present invention has the following beneficial effects:

[0016] 1. The preparation device of the key intermediate of tedizolid drives the rotating rod, the second pulley and the second bevel gear to rotate through the output end of the servo motor. When the second pulley rotates, the reciprocating screw rod, the first pulley and the gear on the left side are driven to rotate through the first belt. When the left gear rotates, it drives another gear and another reciprocating screw rod to rotate, and then the two reciprocating screw rods rotate. When rotating, two threaded sleeves and multiple stirring blades on their outer rings are driven to reciprocate up and down together with the mixing piece through the screw rod hole. At the same time, when the second bevel gear rotates, it drives the first bevel gear and the connecting rod to rotate together with the auger, which can facilitate the operator to reduce the energy consumption of the multiple mixing work of reciprocating up and down and horizontal stirring of the tedizolid raw material in the box, thereby preventing the phenomenon of incomplete mixing, and effectively improving the mixing effect of the tedizolid raw material in the box when preparing the intermediate.

[0017] 2. The preparation device of the key intermediate of tedizolid uses an exhaust fan to suck the external constant temperature gas through the conveying pipe into the heating device. After entering, the control panel controls a suitable number of heating rods to open according to the required temperature to generate heat to heat the constant temperature gas. After heating, the suction dual-purpose pump sucks the first connecting pipe and the first transverse pipe connected by the double-way pipe to pump the high-temperature gas in the heating device into the gas conveying pipe. When entering, the rotation of the first pulley on the right side drives the third pulley and the jet disk to rotate through the second belt, and the hot gas is ejected into the box body during rotation, and the first connecting pipe is rotated clockwise. The valve on the through pipe is closed, and then the valve on the second connecting pipe is turned counterclockwise to open it. After opening, the dual-purpose pump sucks the hot gas in the box into its inner cavity through the double-way pipe to the second connecting pipe, and then transports it back to the heating device through the second transverse pipe for reheating. This makes it convenient for the operator to not only inject hot gases of different temperatures into the box to react with the tedizolid raw materials, but also to perform recycling heating on the hot gas, so that the device can always react quickly when preparing the key intermediate of tedizolid, so that the preparation work of the device is effectively improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 A three-dimensional diagram of the structure of the present invention;

[0019] Figure 2 A three-dimensional diagram of a partial structure of a mixing assembly of the present invention;

[0020] Figure 3 It is a three-dimensional diagram of the auger structure of the present invention;

[0021] Figure 4 A three-dimensional diagram of the drive assembly structure of the present invention;

[0022] Figure 5 A three-dimensional diagram of the heating assembly structure of the present invention;

[0023] Figure 6 It is a three-dimensional diagram of the heating rod structure of the present invention.

[0024] In the figure: 1, box body; 2, reciprocating screw; 3, first pulley; 4, gear; 5, threaded sleeve; 6, screw hole; 7, stirring blade; 8, mixing piece; 9, limit ring; 10, connecting rod; 11, first bevel gear; 12, auger; 13, connecting frame; 14, servo motor; 15, rotating rod; 16, second pulley; 17, first belt; 18, second bevel gear; 19, heating device; 20, exhaust fan; 21, filter screen; 22, heating rod; 23, control panel; 24, suction and extraction dual-purpose pump; 25, double-way pipe; 26, first connecting pipe; 27, second connecting pipe; 28, first transverse pipe; 29, second transverse pipe; 30, air supply pipe; 31, third pulley; 32, jet disc; 33, valve; 34, discharge trough; 35, discharge hopper; 36, second belt. DETAILED DESCRIPTION

[0025] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0026] See also Figure 1-Figure 6 , a preparation device for a key intermediate of tedizolid, comprising a housing 1, a driving assembly is arranged outside the housing 1, a mixing assembly is arranged inside the housing 1, a heating assembly is arranged on the right side of the housing 1, a discharge chute 34 is opened on the right side of the housing 1, and a discharge hopper 35 is fixedly connected to the inner cavity of the discharge chute 34;

[0027] The mixing component comprises two reciprocating screws 2 rotatably connected to the inner cavity of the casing 1 through two bearings and a connecting rod 10 rotatably connected to the left side of the casing 1 through a bearing, the outer rings of the two reciprocating screws 2 are both provided with a first pulley 3, the middle parts of the two reciprocating screws 2 are both provided with a gear 4, the outer rings of the two reciprocating screws 2 located inside the casing 1 are both provided with a threaded sleeve 5, the tops of the two threaded sleeves 5 are penetrated with a screw hole 6 which is adapted to the reciprocating screws 2, the outer rings of the two threaded sleeves 5 are provided with a plurality of stirring blades 7, the left side of the connecting rod 10 penetrates the casing 1 and is fixedly connected with a first bevel gear 11, the outer ring of the connecting rod 10 is fixedly connected with an auger 12, the outer ring size of the auger 12 is larger than the inner wall size of the discharge trough 34, and the provided mixing component can facilitate the operator to simultaneously perform dual mixing operations of up and down flipping and horizontal stirring on the tedizolid raw material in the casing 1, thereby preventing the phenomenon of incomplete mixing and effectively improving the mixing effect of the tedizolid raw material in the casing 1 when preparing the intermediate.

[0028] The driving assembly includes a connecting frame 13 fixedly connected to the outside of the box body 1, a servo motor 14 is arranged on the top of the connecting frame 13, an output end of the servo motor 14 is provided with a rotating rod 15 through a coupling, and an outer ring of the rotating rod 15 is provided with a second pulley 16. Through the provided driving assembly, it is convenient for an operator to drive the mixing assembly to perform double mixing of the tedizolid raw materials, thereby reducing the energy consumption of the device when in use.

[0029] Furthermore, a mixing sheet 8 is fixedly connected between every two staggered stirring blades 7, and the mixing sheets 8 are all arranged in an inclined shape. By setting the mixing sheets 8 in an inclined shape, the contact area between the stirring blades 7 and the tedizolid raw material can be increased, thereby improving the mixing effect of the tedizolid raw material.

[0030] Furthermore, the second pulley 16 is movably sleeved with a first belt 17 on the outer ring of the first pulley 3 on the left, and a second bevel gear 18 is fixedly connected to the bottom of the rotating rod 15. The second bevel gear 18 is meshingly connected to the first bevel gear 11. Through the provision of the first belt 17, the reciprocating screw rod 2 on the left and the corresponding first pulley 3 can rotate together when the second pulley 16 rotates, and through the meshing connection of the second bevel gear 18 and the first bevel gear 11, the first bevel gear 11 and the auger 12 can be driven to rotate together when the second bevel gear 18 rotates, thereby reducing the required energy consumption.

[0031] Furthermore, the bottoms of the two reciprocating screw rods 2 are fixedly connected with limit rings 9, and the two limit rings 9 do not contact the auger 12 and are separated by a distance equal to the inner wall of the discharge trough 34. By setting the limit rings 9, the reciprocating screw rod 2 can be limited when driving the threaded sleeve 5 and the multiple stirring blades 7 on its outer ring to move, preventing the reciprocating screw rod 2 from moving out, and the lack of contact with the auger 12 can prevent the undesirable phenomenon of interference during movement.

[0032] Further, the heating assembly includes a heating device 19 fixedly connected to the right side of the box body 1, an exhaust fan 20 is fixedly connected to the right side of the heating device 19, a filter screen 21 is fixedly connected to the air inlet of the exhaust fan 20, an air pipe is sleeved between the exhaust fan 20 and the heating device 19, a plurality of heating rods 22 are arranged inside the heating device 19, a control panel 23 is arranged on the front of the heating device 19, a suction dual-purpose pump 24 is arranged on the top of the heating device 19, a double-way pipe 25 is arranged on the top of the suction dual-purpose pump 24, a first connecting pipe 26 and a second connecting pipe 27 are sleeved on both sides of the double-way pipe 25 and the top and front of the box body 1, respectively, and the first connecting pipe 26 and the second connecting pipe 27 are sleeved with the heating device 19 A first transverse tube 28 and a second transverse tube 29 are respectively sleeved therebetween, the inner cavity of the first connecting tube 26 is provided with a sealed bearing, the inner cavity of the first connecting tube 26 is rotatably connected to an air supply pipe 30 through a sealed bearing, the outer ring of the air supply pipe 30 is sleeved with a third pulley 31, the bottom of the air supply pipe 30 is sleeved with a jet disk 32, the third pulley 31 and the outer ring of the first pulley 3 on the right side are movably sleeved with a second belt 36, and the heating component is provided, so that the operator can not only inject hot gases of different temperatures into the box body 1 to react with the tedizolid raw materials, but also recover and circulate the hot gases for heating, thereby effectively improving the performance of the device in preparing the key intermediate of tedizolid.

[0033] Furthermore, valves 33 are provided at the tops of the first connecting pipe 26 and the second connecting pipe 27, and the control panel 23 is electrically connected to the plurality of heating rods 22. Through the two valves 33, the operator can conveniently open the first connecting pipe 26 to transport the hot gas in the heating device 19 to the box body 1 or open the second connecting pipe 27 to recover the hot gas in the box body 1, thereby preventing conflicts when hot gas needs to be transported or recovered; by electrically connecting the control panel 23 to the plurality of heating rods 22, an appropriate number of heating rods 22 can be opened or closed according to the required temperature through the control panel 23, thereby enabling the hot gas transported to the box body 1 to be at a suitable temperature.

[0034] Working principle: the output end of the servo motor 14 drives the rotating rod 15 and the second pulley 16 and the second bevel gear 18 to rotate. When the second pulley 16 rotates, the reciprocating screw 2 on the left and the first pulley 3 and the gear 4 are driven to rotate through the first belt 17. When the left gear 4 rotates, it drives another gear 4 and another reciprocating screw 2 to rotate, and then the two reciprocating screws 2 rotate. When rotating, the two threaded sleeves 5 and the multiple stirring blades 7 and the mixing piece 8 on the outer ring are driven to reciprocate up and down through the screw hole 6. At the same time, the second bevel gear 18 When rotating, the first bevel gear 11 and the connecting rod 10 are driven to rotate together with the auger 12, so that the operator can reduce the energy consumption of multiple mixing operations of up and down reciprocating flipping and horizontal stirring of the tedizolid raw material in the box 1, thereby preventing the phenomenon of incomplete mixing and effectively improving the mixing effect of the tedizolid raw material in the box 1 when preparing the intermediate; when the tedizolid raw material is stirred and mixed, the external constant temperature gas is sucked into the heating device 19 through the conveying pipe by the exhaust fan 20, and after entering, it is controlled by the control surface according to the required temperature. The plate 23 controls the appropriate number of heating rods 22 to open to generate heat to heat the constant temperature gas. After heating, the first connecting pipe 26 and the first transverse pipe 28 connected by the double-way pipe 25 are sucked by the dual-purpose suction pump 24, and the high-temperature gas in the heating device 19 is pumped into the gas delivery pipe 30. When entering, the rotation of the first pulley 3 on the right side drives the third pulley 31 and the jet disc 32 to rotate through the second belt 36, and the hot gas is ejected into the box body 1 during rotation, and the valve 33 on the first connecting pipe 26 is turned clockwise to close it, and then the second connecting pipe 2 is turned counterclockwise. 7 is opened, and after opening, the dual-purpose pump 24 sucks the hot gas in the box body 1 into its inner cavity through the double-way pipe 25 and the second connecting pipe 27, and then transports it back to the heating device 19 through the second transverse pipe 29 for reheating, which is convenient for the operator to not only inject hot gases of different temperatures into the box body 1 to react with the tedizolid raw materials, but also to perform recycling heating on the hot gases, so that the device can always react quickly when preparing the key intermediate of tedizolid, so that the preparation work of the device is effectively improved.

[0035] In the description of the present invention, it is necessary to understand that the terms "center", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0036] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0037] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, an electrical connection, or a communication; it can be a direct connection, or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0038] In the present invention, unless otherwise clearly specified and limited, the first feature "on" or "under" the second feature may be that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediate medium. In the description of this specification, the description with reference to the terms "one scheme", "some schemes", "examples", "specific examples", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the scheme or example are included in at least one scheme or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same scheme or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more schemes or examples in a suitable manner.

[0039] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A device for preparing a key intermediate of tedizolid, comprising a housing (1), characterized in that: A driving assembly is arranged outside the box (1), a mixing assembly is arranged inside the box (1), a heating assembly is arranged on the right side of the box (1), a discharge chute (34) is opened on the right side of the box (1), and a discharge hopper (35) is fixedly connected to the inner cavity of the discharge chute (34); The mixing assembly comprises two reciprocating screws (2) rotatably connected to the inner cavity of the housing (1) via two bearings and a connecting rod (10) rotatably connected to the left side of the housing (1) via a bearing, the outer rings of the two reciprocating screws (2) are both fitted with a first pulley (3), the middle parts of the two reciprocating screws (2) are both fitted with a gear (4), the outer rings of the two reciprocating screws (2) located inside the housing (1) are both fitted with a threaded sleeve (5), the tops of the two threaded sleeves (5) are penetrated with a screw hole (6) that is mutually compatible with the reciprocating screws (2), the outer rings of the two threaded sleeves (5) are provided with a plurality of stirring blades (7), the left side of the connecting rod (10) penetrates the housing (1) and is fixedly connected to a first bevel gear (11), and the outer ring of the connecting rod (10) is fixedly connected to an auger (12); The driving assembly comprises a connecting frame (13) fixedly connected to the outside of the box body 1, a servo motor (14) is arranged on the top of the connecting frame (13), an output end of the servo motor (14) is sleeved with a rotating rod (15) through a coupling, and an outer ring of the rotating rod (15) is sleeved with a second pulley (16).

2. The preparation device of a key intermediate of tedizolid according to claim 1, characterized in that: A mixing sheet (8) is fixedly connected between every two of the staggered stirring blades (7), and the mixing sheets (8) are all arranged in an inclined shape.

3. The preparation device of a key intermediate of tedizolid according to claim 1, characterized in that: The outer ring of the auger (12) is larger than the inner wall of the discharge trough (34).

4. The preparation device of a key intermediate of tedizolid according to claim 1, characterized in that: The second belt pulley (16) is movably sleeved with a first belt (17) on the outer ring of the first belt pulley (3) on the left side, and the bottom of the rotating rod (15) is fixedly connected with a second bevel gear (18).

5. The device for preparing a key intermediate of tedizolid according to claim 1, characterized in that: The second bevel gear (18) is meshingly connected with the first bevel gear (11).

6. The device for preparing a key intermediate of tedizolid according to claim 1, characterized in that: The bottoms of the two reciprocating screw rods (2) are fixedly connected to a limit ring (9), and the two limit rings (9) are not in contact with the auger (12) and are separated by a distance equal to the inner wall of the discharge trough (34).

7. The device for preparing a key intermediate of tedizolid according to claim 1, characterized in that: The heating assembly comprises a heating device (19) fixedly connected to the right side of the housing (1), an exhaust fan (20) fixedly connected to the right side of the heating device (19), a filter screen (21) fixedly connected to the air inlet of the exhaust fan (20), an air supply pipe sleeved between the exhaust fan (20) and the heating device (19), a plurality of heating rods (22) arranged inside the heating device (19), a control panel (23) arranged on the front side of the heating device (19), a suction dual-purpose pump (24) arranged on the top of the suction dual-purpose pump (24), a double-way pipe (25) arranged on the top of the double-way pipe (25), both sides of the double-way pipe (25) being connected to the housing (1) ) is respectively sleeved with a first connecting pipe (26) and a second connecting pipe (27) on the top and front of the heating device (19); a first transverse pipe (28) and a second transverse pipe (29) are respectively sleeved between the first connecting pipe (26) and the second connecting pipe (27) and the heating device (19); a sealing bearing is provided in the inner cavity of the first connecting pipe (26); an air supply pipe (30) is rotatably connected to the inner cavity of the first connecting pipe (26) through the sealing bearing; a third pulley (31) is sleeved on the outer ring of the air supply pipe (30); a jet disc (32) is sleeved on the bottom of the air supply pipe (30); a second belt (36) is movably sleeved between the third pulley (31) and the outer ring of the first pulley (3) on the right side.

8. The device for preparing a key intermediate of tedizolid according to claim 7, characterized in that: The tops of the first connecting pipe (26) and the second connecting pipe (27) are both provided with valves (33), and the control panel (23) and the plurality of heating rods (22) are all electrically connected.

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