3-hydroxy-2, 4-dichloroacetophenone prepared by one-pot method and preparation method thereof
Through Fries' photorearrangement method and corn bran extraction technology, 3-hydroxy-2,4-dichloroacetophenone was prepared, solving the problems of flammable acylating agents and complex processes in traditional processes, and achieving an efficient, safe and environmentally friendly preparation method.
CN119707655APending Publication Date: 2025-03-28JIANGXI YONGTONG TECHNOLOGY CO LTD
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Patent Information
- Application Number
- CN202510030169.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-08
- Publication Date
- 2025-03-28
AI Technical Summary
Technical Problem
In the traditional process of preparing 2,4-dichloroacetophenone, flammable acylating agents have a risk of explosion, and the process is complex and there are many by-products, making it difficult to achieve efficient and safe preparation.
Method used
3-hydroxy-2,4-dichloroacetophenone was prepared under mild reaction conditions by Fries' photorearrangement method, and ethyl 3-hydroxy-2,4-dichlorobenzoate was extracted using corn bran, and high selectivity was achieved through one-pot reaction, reducing the generation of by-products.
Benefits of technology
The high selective formation of 3-hydroxy-2,4-dichloroacetophenone is achieved, which simplifies the separation and purification process, reduces production costs, and has environmentally friendly characteristics.
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Abstract
The invention relates to 3-hydroxy-2, 4-dichloroacetophenone prepared by a one-pot method and a preparation method of the 3-hydroxy-2, 4-dichloroacetophenone, and belongs to the technical field of organic synthesis. The 3-hydroxy-2, 4-dichloroacetophenone prepared by the one-pot method is prepared from the following raw materials: ethyl 3-hydroxy-2, 4-dichlorobenzoate, an organic solvent, a catalyst and a photosensitizer. The preparation method of the 3-hydroxy-2, 4-dichlorobenzoic acid ethyl ester comprises the following steps: corn bran extraction, acidification, chlorination, reflux, extraction and evaporation. The 3-hydroxy-2, 4-dichlorobenzoic acid ethyl ester containing a benzene ring is introduced into a reaction route disclosed by the invention, the 3-hydroxy-2, 4-dichloroacetophenone is obtained through a Fries light rearrangement reaction route, an acyl compound can be specifically generated on an aromatic ring without influencing other functional groups, and the method has the characteristics of simple operation and mild reaction conditions. The 3-hydroxy-2, 4-dichlorobenzoic acid ethyl ester is a byproduct corn bran from corn processing, and has the characteristics of high additional value utilization and environmental friendliness.
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