Active polypeptide Tigerin-OL1 capable of promoting healing of oral ulcer and application of active polypeptide Tigerin-OL1

By developing the active polypeptide Tigerin-OL1 from Zef-derived, the existing oral ulcer treatment drugs have limited effects and major side effects have been solved, and an efficient and safe healing effect of oral ulcers has been achieved, and a new way for drug development has been provided.

CN119708136APending Publication Date: 2025-03-28KUNMING MEDICAL UNIVERSITY
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Patent Information

Application Number
CN202411771541.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-04
Publication Date
2025-03-28

AI Technical Summary

Technical Problem

The existing oral ulcer treatment drugs have limited effect, and some drugs require frequent administration or intravenous injection, which has side effects and lacks new oral ulcer healing drugs that are efficient, safe and have few side effects.

Method used

A Zef-derived active polypeptide Tigerin-OL1, derived from oral ulcer healing, has an amino acid sequence of ICTMIPISRCY, which is prepared by chemical synthesis or gene expression, and is used to prepare oral ulcer healing drugs.

Benefits of technology

Tigerin-OL1 has excellent oral ulcer healing activity in vivo and in vitro, and is easy to synthesize, providing a new way to promote the development of oral ulcer healing drugs, and is non-toxic.

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Abstract

The invention discloses an active polypeptide Tigerin-OL1 capable of promoting healing of oral ulcer and application of the active polypeptide Tigerin-OL1. The active polypeptide Tigerin-OL1 capable of promoting healing of the oral ulcer has an amino acid sequence ICTMIPISRCY as shown in SEQ ID No.1 (sequence identifier number 1). The application of the polypeptide Tigerin-OL1 is the application of the polypeptide Tigerin-OL1 in preparation of drugs for promoting healing of oral ulcer. The polypeptide Tigerin-OL1 provided by the invention has excellent oral ulcer healing promoting activity in vivo and in vitro, only contains 11 amino acids and is easy to synthesize, and a new way is provided for development of drugs for promoting oral ulcer healing.
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