Ampoule bottle and penicillin bottle laser detection device and detection method
By adopting tilt optical path technology, rotational vibration mechanism and WMS wavelength modulation technology in the laser detection devices of ampoule and cilillin bottles, the problem of low detection efficiency in the existing technology is solved, and efficient and accurate leakage detection is achieved, meeting the needs of full inspection.
Patent Information
- Application Number
- CN202411682439.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-22
- Publication Date
- 2025-03-28
AI Technical Summary
The prior art is less efficient in detecting leakage of ampoules and cillin bottles, and cannot fully meet the needs of full inspection, and cannot completely replace the non-destructive testing advantages of laser detection.
A laser detection device for ampoule and cilillin bottle is adopted, and the tilt optical path technology and rotational vibration mechanism are used, combined with WMS wavelength modulation technology, and the precise adjustment of the laser emitter and receiver and the use of nitrogen outlet pipes are achieved efficiently detecting the oxygen content in the glass bottle.
It improves the accuracy and efficiency of detection, increases the signal-to-noise ratio by 3 times, greatly enhancing the credibility of data, and shortens the detection time to 1-2 seconds, meeting the needs of efficient and comprehensive inspection.
Smart Images
Figure CN119715457A_ABST
Abstract
Description
Technical Field
[0001] The invention relates to a laser detection device and a detection method for an ampoule bottle and a vial. Background Art
[0002] An ampoule is a hard glass container that can be melted and sealed, commonly used to store injectable drugs, vaccines, sera, etc., while a vial is a small bottle sealed with a rubber stopper and an aluminum-plastic combination cap, generally used for packaging vaccines, biologics, powder injections, freeze-dried drugs and other medicines. These two types of glass bottles are more common packaging bottles in the pharmaceutical industry.
[0003] Ampoules and vials need to be tested for sealing after filling. Currently, most ampoule and vial leaks on the market use the vacuum decay method to establish a vacuum condition. Under the vacuum condition, the gas or liquid in the glass bottle will overflow into the test chamber. The leak is determined by monitoring the change of the vacuum pressure in the test chamber. Although this method can detect tiny leaks in the bottle, each bottle to be tested must be evacuated during the test, which takes a long time. Compared with the laser detection method for leak detection, the vacuum decay method is less efficient and is a destructive test, which is wasteful and cannot fully meet the needs of full inspection. Laser detection is non-destructive.
[0004] At present, WMS wavelength modulation technology (wavelength modulation spectroscopy) can be used in China to detect gas content. It transfers the frequency of the absorption spectrum to high frequency, and superimposes a slightly high-frequency sinusoidal modulation signal on the low-frequency sawtooth signal. This is used as the driving current source for the tunable semiconductor laser. Since the influence of noise mainly exists at low frequencies, WMS technology not only realizes the dual modulation of the wavelength and intensity of the laser output light, but also effectively suppresses the laser intensity noise and the 1 / f noise faced by the detector. It effectively reduces noise interference and greatly broadens the detection limit. However, there is currently no precedent in China for applying WMS wavelength modulation technology to the field of detecting ampoule and vial leakage. Summary of the invention
[0005] The technical problem to be solved by the present invention is to provide a laser detection device for ampoules and vials, which has a simple structure, high working efficiency and high detection accuracy.
[0006] To solve the above problems, the present invention adopts the following technical solutions: A laser detection device for ampoules and vials comprises a bottom plate and a side support plate, wherein the side support plate is vertically mounted on the bottom plate, a screw motor and a slide rail are mounted on the side support plate, a first movable plate and a second movable plate are slidably connected to the slide rail, a screw is connected to an output end of the screw motor, and the screw is threadedly connected to the first movable plate and the second movable plate respectively, a support seat is mounted on the bottom plate, a vibrator is mounted on the support seat, a rotating base is rotatably connected to the support seat, a laser transmitter is mounted on the first movable plate, a laser receiver is mounted on the second movable plate, the laser transmitter is tilted relative to a horizontal plane of the bottom plate, a laser transmitter head and an aspherical lens group are also mounted in the laser transmitter, and nitrogen outlet pipes are relatively fixed on the first movable plate and the second movable plate.
[0007] A further technical solution is that the angle between the laser emitter and the bottom plate is α, and α is 1° to 15°. During the residual oxygen concentration detection process of the glass bottle (the present embodiment takes the vial as an example), the laser is affected by the refraction and reflection of the glass bottle wall, and there is a standard effect. The generated optical interference fringes will affect the uncertainty of the measurement and may even cause the peak drift and distortion of the second harmonic signal, seriously interfering with the accuracy of the detection result. To solve this problem, this product uses tilted optical path technology, so that the laser beam of the laser emitter does not interfere with the light beam generated after transmitting the glass bottle wall multiple times, effectively reducing the interference of light interference on the signal waveform, and the signal-to-noise ratio is improved compared with before the tilt, which greatly enhances the credibility of the obtained data.
[0008] A further technical solution is that a bearing is installed in the support seat, the rotating base is installed in the bearing, and a rotating motor (not shown) is also installed in the support seat. The output end of the rotating motor is connected to the rotating base, and the rotating base can rotate relative to the support seat, so that the laser beam can be incident on the glass bottle at different angles, thereby averaging the signal intensity fluctuations caused by the interference effect. This effectively reduces the abnormal signal fluctuations that may be caused by a single angle of incidence, and the signal-to-noise ratio is greatly improved before rotation, and the accuracy is further improved.
[0009] A further technical solution is that the Y-shaped nitrogen outlet pipe is fixed to the first movable plate and the second movable plate by adhesion, and the adhesion can be glass glue, tape or glue or other adhesives, and of course, other relative fixing methods can also be used.
[0010] A further technical solution is that a screw bearing seat is also fixed on the side support plate, the other end of the screw is rotatably connected to the screw bearing seat, a bearing is fixed in the screw bearing seat, and the other end of the screw is connected to the bearing to achieve a rotatable effect, thereby improving the stability of the screw during rotation.
[0011] A further technical solution is that the nitrogen outlet pipe is a Y-shaped nitrogen outlet pipe, one end of which is connected to an external nitrogen generator, and the other end is divided into two outlets for blowing air around the laser transmitter and the laser receiver respectively.
[0012] Another technical problem to be solved by the present invention is to provide a detection method of an ampoule and a vial laser detection device which is easy to operate.
[0013] In order to solve the above technical problems, the present invention adopts the following technical scheme: comprising the following steps: 1), first, the screw motor is started to drive the screw to rotate, and after the screw rotates, it can drive the first movable plate and the second movable plate to move relative to each other to adjust the distance between the laser transmitter and the laser receiver on the first movable plate and the second movable plate and the glass bottle; 2), then the rotating motor and the vibrator are started, the rotating motor drives the rotating base to rotate, the rotating base rotates and drives the glass bottle to rotate, and at the same time, the vibrator is used to vibrate the entire rotating base; 3), then nitrogen is released through the nitrogen outlet pipe outlet to aim at the laser transmitter and the laser receiver; 4), finally, the laser transmitter is started to emit laser light through the glass bottle and then received by the laser receiver.
[0014] The beneficial effects of the present invention are: 1) An aspheric lens group is also installed in the laser transmitter. The use of the aspheric lens group for beam shaping can effectively reduce the divergence angle of the beam from 20° vertical divergence angle and 10° horizontal divergence angle to 3°, achieving uniform distribution of light spot intensity, concentrating laser energy, and improving measurement accuracy; 2) The laser transmitter is tilted relative to the horizontal plane of the bottom plate, and the tilted optical path design is used to prevent the laser beam from interfering with the light beam after it passes through the glass bottle wall multiple times, effectively reducing the interference of light interference on the signal waveform. The signal-to-noise ratio is increased by 3 times compared to before the tilt, which greatly enhances the credibility of the obtained data; 3) The support base is rotatably connected to a rotating base, and the glass bottle to be tested is placed on the rotating base and rotates with it. During the rotation, the vibrator generates continuous small vibrations. This composite motion mechanism enables the laser beam to be incident into the bottle at different angles, thereby averaging the signal intensity fluctuations caused by the interference effect. This effectively reduces the abnormal signal fluctuations that may be caused by a single angle of incidence, and the signal-to-noise ratio is greatly improved before rotation, and the accuracy is further improved; 4) A screw is connected to the output end of the screw motor, and the screw is threadedly connected to the first movable plate and the second movable plate respectively. The rotation of the screw can drive the first movable plate and the second movable plate to move. While moving, the first movable plate and the second movable plate are slidably connected to the slide rail on the side support plate. This design optimizes the relative position of the laser transmitter and the laser receiver relative to the body of the detected glass bottle, ensuring that they are as close as possible, thereby effectively shortening the propagation distance of the laser in the external ambient air and reducing the interference of the oxygen environment factors in the air outside the glass bottle on the optical path on the laser transmission process; 5) Nitrogen outlet pipes are relatively fixed on the first movable plate and the second movable plate. The nitrogen outlet pipes output a nitrogen flow rate of 1.5L / min, covering the laser transmitter, laser receiver and the surrounding environment of the glass bottle in all directions without dead angles, effectively preventing system damage or performance degradation caused by impurities intrusion, and reducing the interference of oxygen outside the bottle, thereby improving the accuracy and reliability of detection, and further improving the stability and reliability of the product; 6) During the test, place a glass bottle on the rotating base, turn on the laser transmitter and laser receiver to detect whether there is oxygen in the glass bottle, and then find out whether the glass bottle is leaking. After the current glass bottle is tested, another glass bottle can be immediately replaced for testing. Each test takes 1-2 seconds, and the detection efficiency is very high. BRIEF DESCRIPTION OF THE DRAWINGS
[0015] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. It is obvious that the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.
[0016] Figure 1 It is a structural schematic diagram of a laser detection device for ampoules and vials of the present invention; Figure 2 The present invention is a schematic diagram of a laser transmitter in an ampoule and vial laser detection device when the laser is transmitted through a glass bottle and then received by a laser receiver.
[0017] Figure 1-2 Middle: 1-side support plate, 2-screw bearing seat, 3-slide rail, 4-first movable plate, 5-screw, 6-second movable plate, 7-screw motor, 8-bottom plate, 9-laser transmitter, 10-laser receiver, 11-glass bottle, 12-rotating base, 13-bearing, 14-support seat, 15-vibrator, 16-nitrogen outlet pipe, 91-laser transmitter head, 92-aspherical lens group. DETAILED DESCRIPTION
[0018] The preferred embodiments of the present invention are described in detail below in conjunction with the accompanying drawings so that the advantages and features of the present invention can be more easily understood by those skilled in the art, thereby making a clearer and more definite definition of the protection scope of the present invention.
[0019] See also Figure 1 and Figure 2 As shown, a laser detection device for ampoules and vials comprises a bottom plate 8 and a side support plate 1, the side support plate 1 is vertically mounted on the bottom plate 8, a screw motor 7 and a slide rail 3 are mounted on the side support plate 1, a first movable plate 4 and a second movable plate 6 are slidably connected to the slide rail 3, a screw motor 7 is connected to an output end of the screw motor 7, the screw rod 5 is threadedly connected to the first movable plate 4 and the second movable plate 6 respectively, a support seat 14 is mounted on the bottom plate 8, a vibrator 15 is mounted on the support seat 14, a rotating base 12 is rotatably connected to the support seat 14, a laser transmitter 9 is mounted on the first movable plate 4, a laser receiver 10 is mounted on the second movable plate 6, the laser transmitter 9 is tilted relative to the horizontal plane of the bottom plate 8, a laser transmitter head 91 and an aspherical lens group 92 are also mounted in the laser transmitter 9, and a nitrogen outlet pipe 16 is relatively fixed to the first movable plate 4 and the second movable plate 6.
[0020] The angle between the laser emitter 9 and the bottom plate 8 is α, and α is 1° to 15°. When the tilt angle α is 1° to 15°, the laser is affected by the refraction and reflection of the wall of the glass bottle 11 during the residual oxygen concentration detection process of the glass bottle 11 (the embodiment takes the vial as an example), and there is a standard effect. The generated optical interference fringes will affect the uncertainty of the measurement and may even cause the peak drift and distortion of the second harmonic signal, which seriously interferes with the accuracy of the detection result. To solve this problem, this product uses tilted optical path technology to prevent the laser beam of the laser emitter 9 from interfering with the light beam generated after it passes through the wall of the glass bottle 11 multiple times, effectively reducing the interference of light interference on the signal waveform, and the signal-to-noise ratio is increased by 3 times compared with before the tilt, which greatly enhances the credibility of the obtained data.
[0021] A bearing 13 is installed in the support seat 14, and a rotating base 12 is installed in the bearing 13. A rotating motor (not shown) is also installed in the support seat 14. The output end of the rotating motor is connected to the rotating base 12. The rotating base 12 can rotate relative to the support seat 14, so that the laser beam can be incident into the glass bottle 11 at different angles, thereby averaging the signal intensity fluctuations generated by the interference effect. This effectively reduces the abnormal signal fluctuations that may be caused by a single angle of incidence, and the signal-to-noise ratio is greatly improved before rotation, and the accuracy is further improved. The Y-shaped nitrogen outlet pipe 16 is fixed to the first movable plate 4 and the second movable plate 6 by adhesion. The adhesion can be glass glue, tape or glue or other adhesives, and of course, it can also be fixed by other relative methods. A screw bearing seat 2 is also fixed on the side support plate 1, and the other end of the screw 5 is rotatably connected to the screw bearing seat 2. A bearing is fixed in the screw bearing seat 2, and the other end of the screw 5 is connected to the bearing to achieve a rotatable effect, thereby improving the stability of the screw 5 during rotation. The nitrogen outlet pipe 16 is a Y-shaped nitrogen outlet pipe, one end of which is connected to an external nitrogen generator, and the other end is divided into two outlets for blowing air toward the periphery of the laser transmitter 9 and the laser receiver 10 respectively.
[0022] The detection method of the laser detection device for ampoule bottles and vials comprises the following steps: 1) firstly, the screw motor 7 is started to drive the screw 5 to rotate, and the screw 5 can drive the first movable plate 4 and the second movable plate 6 to move relative to each other after the rotation, so as to adjust the distance between the laser emitter 9 and the laser receiver 10 on the first movable plate 4 and the second movable plate 6 and the glass bottle 11; 2) then, the rotating motor and the vibrator 15 are started, the rotating motor drives the rotating base 12 to rotate, and the rotating base 12 rotates to drive the glass bottle 11 to rotate, and at the same time, the vibrator 15 is used to vibrate the entire rotating base 12; 3) then, nitrogen is released through the nitrogen outlet pipe 16 to aim at the periphery of the laser emitter 9 and the laser receiver 10; 4) finally, the laser emitter 9 is started to emit laser light, which passes through the glass bottle 11 and is received by the laser receiver 10.
[0023] Among them, this device uses WMS wavelength modulation technology, and the laser is emitted from the laser transmitter 9 to penetrate the glass bottle 11 and then received by the laser receiver 10, and finally the oxygen content in the glass bottle 11 is obtained. The minimum measurable oxygen concentration is 0.42%.
[0024] The above example is only an example of the present invention and is not intended to limit the implementation and scope of rights of the present invention. Any technical solution that is identical or equivalent to the content described in the claims of the present invention should be included in the protection scope of the present invention.
Claims
1. A laser detection device for ampoules and vials, characterized in that: It includes a bottom plate and a side support plate, the side support plate is vertically mounted on the bottom plate, a screw motor and a slide rail are mounted on the side support plate, a first movable plate and a second movable plate are slidably connected to the slide rail, an output end of the screw motor is connected to a screw, the screw is threadedly connected to the first movable plate and the second movable plate respectively, a support seat is mounted on the bottom plate, a vibrator is mounted on the support seat, a rotating base is rotatably connected to the support seat, a laser transmitter is mounted on the first movable plate, a laser receiver is mounted on the second movable plate, the laser transmitter is tilted relative to the horizontal plane of the bottom plate, a laser transmitter head and an aspherical lens group are also mounted in the laser transmitter, and a nitrogen outlet pipe is relatively fixed on the first movable plate and the second movable plate.
2. The laser detection device for ampoules and vials according to claim 1, characterized in that: There is an inclination angle α between the laser emitter and the bottom plate level, and the α is 1° to 15°.
3. The laser detection device for ampoules and vials according to claim 1, characterized in that: A bearing is installed in the support seat, the rotating base is installed in the bearing, and a rotating motor is also installed in the support seat, and the output end of the rotating motor is connected to the rotating base.
4. The laser detection device for ampoules and vials according to claim 1, characterized in that: The Y-shaped nitrogen outlet pipe is fixed on the first movable plate and the second movable plate by adhesion.
5. The laser detection device for ampoules and vials according to claim 1, characterized in that: A screw bearing seat is also fixed on the side support plate, and the other end of the screw rod is rotatably connected to the screw bearing seat.
6. The laser detection device for ampoules and vials according to claim 1, characterized in that: The nitrogen outlet pipe is a Y-shaped nitrogen outlet pipe.
7. A detection method for the ampoule and vial laser detection device as claimed in claim 1, characterized in that: The following steps are involved: 1) First, the screw motor starts to drive the screw to rotate. After the screw rotates, it can drive the first movable plate and the second movable plate to move relative to each other to adjust the distance between the laser transmitter and the laser receiver on the first movable plate and the second movable plate and the glass bottle; 2) Then start the rotating motor and the vibrator. The rotating motor drives the rotating base to rotate. The rotating base drives the glass bottle to rotate. At the same time, the vibrator is used to vibrate the entire rotating base. 3) Then release nitrogen through the nitrogen outlet pipe outlet towards the laser transmitter and laser receiver; 4) Finally, the laser transmitter starts to emit laser light which passes through the glass bottle and is received by the laser receiver.