Sample analysis apparatus

Abstract

The invention is applicable to the field of in-vitro diagnostic equipment, and discloses sample analysis equipment. The sample analysis equipment comprises a redissolving device, a sample determination device, a transmission device and a control device, and the control device is configured to control the redissolving device to redissolve a freeze-dried standard sample into a liquid standard sample; controlling a transmission device to transmit a standard sample container which is output from the redissolving device and is loaded with at least part of the liquid standard sample to a sample determination device, and controlling the sample determination device to suck at least part of the loaded liquid standard sample from the standard sample container and distribute the liquid standard sample into a first reaction container, and controlling the sample determination device to determine a first reaction liquid prepared from at least the liquid standard sample distributed into the first reaction container in the first reaction container, so as to obtain reference detection data. According to the invention, automatic redissolution of the freeze-dried standard sample in the sample analysis equipment and automatic determination after redissolution are realized, and the workload and operation burden of operators in the determination process of the standard sample are reduced.

Description

Technical Field

[0001] The present invention relates to the field of in vitro diagnostic equipment, and in particular to a sample analysis equipment. Background Art

[0002] Before the sample analysis equipment performs sample measurement items on the patient's test samples every day, it is generally necessary to first perform quality control measurement (i.e., quality control measurement) on the quality control products with known results. By comparing and evaluating the actual measurement results of the quality control products on the sample analysis equipment with the known results (i.e., target values) preset in the sample analysis equipment, it can be confirmed whether the sample analysis equipment is in a normal state. In addition, in order to ensure the accuracy of the measurement results of the sample analysis equipment, it is generally necessary to regularly calibrate the sample measurement items of the sample analysis equipment using calibrators.

[0003] In the related art, in order to obtain a longer shelf life, standard samples such as quality control products and calibration products are generally produced and stored in a freeze-dried form (such as freeze-dried powder form), and the freeze-dried standard samples are manually reconstituted into liquid standard samples by laboratory operators before being measured on the machine. Taking quality control products as an example, the specifications of the first container used to hold freeze-dried quality control products are mostly around 1ml, and the amount of quality control products required for a quality control measurement is much less than 1ml. In order to control costs, most laboratories require that the reconstituted liquid quality control products be packaged in small sizes, for example, the 1ml liquid quality control product reconstituted in the first container is packaged into 5 second containers of 200uL specifications, and the liquid quality control product in one second container is used for machine measurement, and the liquid quality control products in the other 4 second containers are frozen for storage. In the related art, the reconstitution and packaging of freeze-dried quality control products are all completed by manual operation. In specific applications, there are the following shortcomings: on the one hand, the quality control measurement operation process is cumbersome, which increases the operating burden of laboratory operators; on the other hand, the randomness of manual operation may affect the accuracy of the quality control measurement results, which may easily lead to the loss of control of quality control items. Summary of the invention

[0004] The first purpose of the present invention is to provide a sample analysis device, which aims to solve the technical problems that in the sample analysis device of the related art, the freeze-dried standard sample is manually dissolved into a liquid standard sample for measurement, which has a heavy burden on the operator and human operation factors easily lead to inaccurate standard sample measurement results.

[0005] To achieve the above object, the present invention provides a solution: a sample analysis device, comprising:

[0006] A reconstitution device, wherein the reconstitution device is used to reconstitute the freeze-dried standard sample into a liquid standard sample;

[0007] A sample measuring device, the sample measuring device is used to measure the sample to be measured to obtain sample test data, and is used to measure the liquid standard sample to obtain reference test data;

[0008] A transmission device, the transmission device is used to: transmit the standard sample container output from the reconstitution device and loaded with at least a part of the liquid standard sample formed by reconstitution of the freeze-dried standard sample to the sample measurement device;

[0009] A control device, wherein the control device is configured to: control the reconstitution device to reconstitute the freeze-dried standard sample into the liquid standard sample, control the transmission device to transmit the standard sample container output from the reconstitution device and loaded with at least a portion of the liquid standard sample to the sample measurement device, control the sample measurement device to absorb at least a portion of the liquid standard sample loaded in the standard sample container from the standard sample container and distribute it to a first reaction container, and control the sample measurement device to measure a first reaction liquid in the first reaction container made of at least the liquid standard sample distributed to the first reaction container to obtain the reference detection data.

[0010] As an embodiment, the sample measuring device includes a sample storage mechanism, a sample scheduling mechanism, a sample distribution mechanism, a liquid transfer mechanism and a sample measuring mechanism;

[0011] The controlling the transmission device to transmit the standard sample container output from the re-dissolving device and loaded with at least a portion of the liquid standard sample to the sample measuring device comprises: controlling the transmission device to transmit the standard sample container output from the re-dissolving device and loaded with at least a portion of the liquid standard sample to the sample storage mechanism;

[0012] The sample storage mechanism is used to store a sample container loaded with a sample to be tested, and is used to store a standard sample container transferred by the transfer device and loaded with at least a portion of the liquid standard sample;

[0013] The sample scheduling mechanism is used to schedule the standard sample container loaded with at least part of the liquid standard sample from the sample storage mechanism to a first sample suction position, and is used to schedule the sample container loaded with the sample to be tested from the sample storage mechanism to a second sample suction position, wherein the first sample suction position and the second sample suction position are located at the same position or at two different positions;

[0014] The pipetting mechanism is used to draw at least a portion of the liquid standard sample loaded in the standard sample container located at the first sample aspiration position and distribute it into the first reaction container;

[0015] The sample dispensing mechanism is used to absorb at least a portion of the sample to be tested loaded in the sample container located at the second sample aspirating position and distribute it to the second reaction container;

[0016] The sample measuring mechanism is used to measure the first reaction liquid in the first reaction container which is at least made of the liquid standard sample distributed into the first reaction container, and is used to measure the second reaction liquid in the second reaction container which is at least made of the sample to be tested distributed into the second reaction container;

[0017] Wherein, the pipetting mechanism and the sample dispensing mechanism are the same mechanism or two independent mechanisms;

[0018] Preferably, the first reaction container and the second reaction container are two reaction containers of the same shape and size.

[0019] As an embodiment, controlling the transmission device to transmit the standard sample container output from the reconstitution device and loaded with at least a portion of the liquid standard sample to the sample storage mechanism includes: controlling the transmission device to transmit the first sample rack output from the reconstitution device and loaded with the standard sample container to the sample storage mechanism;

[0020] The sample storage mechanism is used to store the first sample rack from the transmission device and loaded with the standard sample container, and is used to store the second sample rack loaded with sample containers and the sample containers are loaded with samples to be tested;

[0021] The sample scheduling mechanism is used to schedule the first sample rack so that the first sample rack from the sample storage mechanism drives the standard sample container loaded with at least part of the liquid standard sample to be scheduled to the first sample suction position, and is used to schedule the second sample rack so that the second sample rack from the sample storage mechanism drives the sample container loaded with the sample to be tested to be scheduled to the second sample suction position;

[0022] The first sample rack has at least two first placement positions, each of which is used to place a single standard sample container, and the second sample rack has at least two second placement positions, each of which is used to place a single sample container;

[0023] Preferably, the first sample rack and the second sample rack are two sample racks of the same shape and size.

[0024] As an embodiment, the sample measuring device includes a sample storage mechanism, a sample scheduling mechanism, a sample dispensing mechanism, a reagent dispensing mechanism, a pipetting mechanism, and a sample measuring mechanism;

[0025] The sample storage mechanism is used to store a sample container loaded with a sample to be tested;

[0026] The sample dispatching mechanism is used to dispatch the sample container loaded with the sample to be tested from the sample storage mechanism to the second sample suction position;

[0027] The sample dispensing mechanism is used to absorb at least a portion of the sample to be tested loaded in the sample container located at the second sample aspirating position and distribute it to the second reaction container;

[0028] The controlling the transmission device to transmit the standard sample container output from the re-dissolving device and loaded with at least a portion of the liquid standard sample to the sample measuring device comprises: controlling the transmission device to transmit the standard sample container output from the re-dissolving device and loaded with at least a portion of the liquid standard sample to a third sample aspiration position, wherein the third sample aspiration position and the second sample aspiration position are located at the same position or at two different positions;

[0029] The controlling the sample measuring device to draw at least a portion of the liquid standard sample loaded in the standard sample container from the standard sample container and distribute it to the first reaction container comprises: controlling the liquid transfer mechanism to draw at least a portion of the liquid standard sample loaded in the standard sample container located at the third sample aspiration position and distribute it to the first reaction container;

[0030] The reagent dispensing mechanism is used to draw reagent from the reagent container and dispense it into the first reaction container, and is used to draw reagent from the reagent container and dispense it into the second reaction container;

[0031] The sample measuring mechanism is used to measure the first reaction liquid in the first reaction container, which is at least the liquid standard sample distributed in the first reaction container and the reagent, and is used to measure the second reaction liquid in the second reaction container, which is at least the sample to be tested distributed in the second reaction container and the reagent;

[0032] The liquid transfer mechanism and the reagent dispensing mechanism are the same mechanism or two independent mechanisms.

[0033] As an embodiment, the sample measuring device comprises a reaction container supply mechanism, a sample dispensing mechanism and a pipetting mechanism, wherein the reaction container supply mechanism has one container output channel, and the container output channel is used to output the first reaction container and to output the second reaction container;

[0034] The pipetting mechanism is used to draw at least a portion of the liquid standard sample loaded in the standard sample container and distribute it to the first reaction container outputted by the container output channel;

[0035] The sample distributing mechanism is used to absorb at least a portion of the sample to be tested loaded in the sample container and distribute it to the second reaction container outputted by the container output channel.

[0036] As an embodiment, the control device is further configured to: control the transport device to transport the standard sample container output from the sample measuring device and after the liquid standard sample is absorbed and dispensed by the sample measuring device to the reconstitution device for storage or recovery.

[0037] As an embodiment, the transmission device includes a transmission track and a first transfer mechanism, and the transmission track is provided with a sample introduction position;

[0038] The controlling the transmission device to transmit the standard sample container output from the reconstitution device and loaded with at least a portion of the liquid standard sample to the sample measurement device comprises:

[0039] Control the transport track to transport the standard sample container output from the reconstitution device and loaded with at least a portion of the liquid standard sample to the sample injection position;

[0040] The first transfer mechanism is controlled to transfer the standard sample container loaded with at least a portion of the liquid standard sample from the sample injection position to the sample measurement device.

[0041] As an embodiment, controlling the transport track to transport the standard sample container output from the reconstitution device and loaded with at least a portion of the liquid standard sample to the sample injection position includes: controlling the transport track to transport the first sample rack output from the reconstitution device and loaded with the standard sample container to the sample injection position;

[0042] The controlling the first transfer mechanism to transfer the standard sample container loaded with at least a portion of the liquid standard sample from the sample injection position to the sample measurement device includes: controlling the first transfer mechanism to transfer the first sample rack loaded with the standard sample container and the standard sample container loaded with at least a portion of the liquid standard sample from the sample injection position to the sample measurement device.

[0043] As an implementation mode, the reconstitution device and the transfer track are respectively distributed on two adjacent sides of the sample determination device.

[0044] As an embodiment, the sample measuring device includes a sample storage mechanism, the sample storage mechanism includes a loading area and an unloading area, the loading area and the unloading area are arranged at intervals along the transmission track, and the loading area and the unloading area are respectively arranged near two ends of the transmission track, and the re-dissolving device is arranged near the unloading area or the loading area;

[0045] The sample introduction position is located at a position where the transmission track is directly opposite to the loading area;

[0046] An entrance and an exit are formed at one end of the transport track away from the reconstitution device, and the entrance and an exit are at least used for inputting a second sample rack loaded with a sample container and the sample container loaded with a sample to be tested;

[0047] The transfer track is used to: transfer the second sample rack loaded with the sample container from the entrance to the sample injection position along a first direction;

[0048] The transport track is also used to: transport the first sample rack output from the reconstitution device and loaded with the standard sample container toward the inlet and outlet to the sample injection position along the second direction;

[0049] The first transfer mechanism is used to transfer the first sample rack located at the sample injection position to the loading area, and is used to transfer the second sample rack located at the sample injection position to the loading area;

[0050] The first direction and the second direction are two opposite directions.

[0051] As an embodiment, the sample measuring device includes a sample storage mechanism, the sample storage mechanism includes a loading area and an unloading area, the loading area and the unloading area are adjacent to or integrated with each other and are arranged near the same end of the transmission track;

[0052] The sample introduction position is located at a position where the transmission track is directly opposite to the loading area;

[0053] The reconstitution device is disposed near one end of the transport track, and an inlet and outlet are formed at one end of the transport track away from the reconstitution device, and the inlet and outlet are at least used for inputting a second sample rack loaded with a sample container and the sample container loaded with a sample to be tested;

[0054] The transfer track is used to: transfer the second sample rack loaded with the sample container from the entrance to the sample injection position along a first direction;

[0055] The transport track is also used to: transport the first sample rack output from the reconstitution device and loaded with the standard sample container toward the inlet and outlet to the sample injection position along the second direction;

[0056] The first transfer mechanism is used to transfer the first sample rack located at the sample injection position to the loading area, and is used to transfer the second sample rack located at the sample injection position to the loading area;

[0057] The first direction and the second direction are two opposite directions.

[0058] As an embodiment, the transport track is also used to transport the sample rack output from the unloading area toward the entrance and exit along the second direction;

[0059] The sample analysis device further includes a first information acquisition component, which is disposed beside the transfer track or on the transfer track, and is used to acquire information of a sample rack output from the unloading area and transferred from the transfer track toward the entrance or exit, or to acquire information of a container loaded on a sample rack output from the unloading area and transferred from the transfer track toward the entrance or exit;

[0060] The control device is also configured to:

[0061] Determine the type of liquid loaded in the container on the sample rack output from the unloading area and transported toward the entrance and exit by the transport track, or determine the type of the container on the sample rack output from the unloading area and transported toward the entrance and exit by the transport track, according to the information of the sample rack or the information of the container fed back by the first information acquisition component;

[0062] If it is determined that the type of the liquid loaded in the container on the sample rack is a sample to be tested or the type of the container loaded on the sample rack is a sample container, then control the transport track to transport the sample rack to the entrance and exit along the second direction for recycling;

[0063] If the type of liquid loaded in the container on the sample rack is determined to be a liquid standard sample or the type of container loaded on the sample rack is determined to be a standard sample container, the transport track is controlled to transport the sample rack along the first direction to the reconstitution device for storage or recovery.

[0064] As an embodiment, the sample measuring device includes a sample storage mechanism, a sample scheduling mechanism, a sample distribution mechanism and a pipetting mechanism;

[0065] The sample storage mechanism includes a loading area, an unloading area and a buffer area;

[0066] The sample scheduling mechanism is used to schedule the first sample rack so that the first sample rack from the loading area drives the standard sample container loaded with at least part of the liquid standard sample to be scheduled to the first sample suction position, and is used to schedule the second sample rack so that the second sample rack from the loading area drives the sample container loaded with the sample to be tested to be scheduled to the second sample suction position;

[0067] The pipetting mechanism is used to draw at least a portion of the liquid standard sample loaded in the standard sample container located at the first sample aspiration position and distribute it into the first reaction container;

[0068] The sample dispensing mechanism is used to absorb at least a portion of the sample to be tested loaded in the sample container located at the second sample aspirating position and distribute it to the second reaction container;

[0069] The control device is also configured to:

[0070] Controlling the sample dispatching mechanism to dispatch the first sample rack loaded with the standard sample container after the standard sample container is sucked and dispensed with the liquid standard sample by the liquid transfer mechanism from the first sample suction position to the buffer area for buffering;

[0071] If information is obtained that the liquid standard sample in at least one of the standard sample containers in the first sample rack cached in the cache area needs to be retested, the sample scheduling mechanism is controlled to schedule the first sample rack loaded with the standard sample container that needs to be retested from the cache area to the first sample aspirating position, and the liquid transfer mechanism is controlled to re-absorb and distribute at least a portion of the liquid standard sample loaded in the standard sample container that needs to be retested located at the first sample aspirating position;

[0072] If information is obtained that the liquid standard samples in all the standard sample containers in the first sample rack cached in the cache area do not need to be retested, the sample scheduling mechanism is controlled to schedule the first sample rack from the cache area to the unloading area;

[0073] The liquid transfer mechanism and the sample distribution mechanism are the same mechanism or two independent mechanisms.

[0074] As an embodiment, the standard sample container includes a first container;

[0075] The controlling the re-dissolving device to re-dissolve the freeze-dried standard sample into the liquid standard sample comprises: controlling the re-dissolving device to re-dissolve the freeze-dried standard sample in the first container into the liquid standard sample;

[0076] The controlling the transmission device to transmit the standard sample container output from the reconstitution device and loaded with at least a portion of the liquid standard sample to the sample measuring device comprises: controlling the transmission device to transmit the first container output from the reconstitution device and loaded with the liquid standard sample to the sample measuring device;

[0077] The controlling the sample measuring device to draw at least a portion of the liquid standard sample loaded in the standard sample container and distribute it into the first reaction container includes: controlling the sample measuring device to draw at least a portion of the liquid standard sample loaded in the first container and distribute it into the first reaction container.

[0078] As an embodiment, controlling the transmission device to transmit the first container output from the reconstitution device and loaded with the liquid standard sample to the sample measuring device comprises: when a first preset condition is met, controlling the transmission device to transmit the first container output from the reconstitution device and loaded with the liquid standard sample to the sample measuring device;

[0079] The controlling the sample measuring device to absorb at least a portion of the liquid standard sample loaded in the first container and distribute it to the first reaction container comprises: controlling the sample measuring device to absorb at least a portion of the liquid standard sample loaded in the first container and distribute it to the first reaction container; controlling the transmission device to transmit the first container output from the sample measuring device and after the sample measuring device absorbs and distributes at least a portion of the liquid standard sample to the reconstitution device for storage or recovery;

[0080] The control device is further configured to: after controlling the transmission device to transmit the first container output from the sample measuring device and after the sample measuring device absorbs and dispenses at least a portion of the liquid standard sample to the reconstitution device for storage, when the first preset condition is met again, determine whether the first container output from the sample measuring device and after the sample measuring device absorbs and dispenses at least a portion of the liquid standard sample meets a second preset condition, and if so, control the reconstitution device to output the first container meeting the second preset condition to the transmission device, and control the transmission device to transmit the first container output from the reconstitution device and meeting the second preset condition to the sample measuring device;

[0081] The second preset condition is that the amount of the liquid standard sample loaded in the first container is greater than or equal to the amount of the liquid standard sample required for a quality control item or a calibration item.

[0082] As an embodiment, the reconstitution device includes a storage mechanism, a reconstitution solution dispensing mechanism, a rewarming mechanism and a second transfer mechanism, and the storage mechanism includes a refrigeration mechanism and / or a freezing mechanism;

[0083] The controlling the reconstitution device to reconstitute the freeze-dried standard sample in the first container into the liquid standard sample comprises: controlling the reconstitution solution dispensing mechanism to dispense the reconstitution solution into the freeze-dried standard sample in the first container, so that the freeze-dried standard sample and the reconstitution solution are mixed to form the liquid standard sample;

[0084] The controlling the transmission device to transmit the first container after the sample measuring device is output and after the sample measuring device absorbs and distributes at least a part of the liquid standard sample to the reconstitution device for storage or recovery includes: controlling the transmission device to transmit the first container after the sample measuring device is output and after the sample measuring device absorbs and distributes at least a part of the liquid standard sample to the refrigeration mechanism or the freezing mechanism for storage;

[0085] The control device is also configured to: before controlling the re-dissolving device to output the first container that meets the second preset condition to the transmission device, control the second transfer mechanism to transfer the first container that meets the second preset condition from the refrigeration mechanism or the freezing mechanism to the rewarming mechanism for heating treatment.

[0086] As an embodiment, the standard sample container includes a first container and a second container;

[0087] The reconstitution device comprises a reconstitution solution dispensing mechanism and a dispensing mechanism;

[0088] The controlling the reconstitution device to reconstitute the freeze-dried standard sample into the liquid standard sample comprises: controlling the reconstitution solution dispensing mechanism to dispense the reconstitution solution into the freeze-dried standard sample in the first container, so that the freeze-dried standard sample and the reconstitution solution are mixed to form the liquid standard sample;

[0089] The controlling the transmission device to transmit the standard sample container output from the re-dissolving device and loaded with at least a portion of the liquid standard sample to the sample measuring device comprises: controlling the dispensing mechanism to absorb at least a portion of the liquid standard sample from the first container and distribute it to at least one of the second containers, and controlling the transmission device to transmit the second container output from the re-dissolving device and loaded with at least a portion of the liquid standard sample to the sample measuring device;

[0090] The shape, volume and material of the second container are the same as those of the first container, or at least one of the shape, volume and material of the second container is different from that of the first container;

[0091] The rehydration solution dispensing mechanism and the dispensing mechanism are the same mechanism or two independent mechanisms.

[0092] As an embodiment, the reconstitution device further comprises a storage mechanism and a second transfer mechanism, wherein the storage mechanism comprises a refrigeration mechanism and / or a freezing mechanism;

[0093] The step of controlling the dispensing mechanism to absorb at least a portion of the liquid standard sample from the first container and distribute it to at least one of the second containers, and controlling the transmission device to transmit the second container output from the reconstitution device and loaded with at least a portion of the liquid standard sample to the sample measurement device, comprises:

[0094] Controlling the dispensing mechanism to absorb at least a portion of the liquid standard sample from the first container and distribute it to at least two of the second containers;

[0095] When the first preset condition is met, the transmission device is controlled to transfer at least one second container output from the reconstitution device and loaded with a portion of the liquid standard sample to the sample measurement device, and the second transfer mechanism is controlled to transfer at least one second container loaded with a portion of the liquid standard sample to the refrigeration mechanism and / or freezing mechanism for storage.

[0096] As an embodiment, the re-dissolving device further includes a re-temperature mechanism;

[0097] The control device is also configured to:

[0098] After controlling the second transfer mechanism to transfer at least one of the second containers loaded with a portion of the liquid standard sample to the refrigerating mechanism and / or freezing mechanism for storage, when the first preset condition is met again, determining whether the second container loaded with a portion of the liquid standard sample and stored in the refrigerating mechanism and / or freezing mechanism meets a third preset condition;

[0099] If yes, controlling the second transfer mechanism to transfer the second container that meets the third preset condition from the refrigeration mechanism or the freezing mechanism to the rewarming mechanism for temperature raising treatment;

[0100] Controlling the re-dissolving device to output the second container after the temperature increase treatment to the transmission device;

[0101] Control the transport device to transport the second container output from the reconstitution device and subjected to the temperature increase process to the sample measuring device;

[0102] The third preset condition is that the amount of the liquid standard sample loaded in the second container is greater than or equal to the amount of the liquid standard sample required for a quality control item or a calibration item.

[0103] As an embodiment, the standard sample container includes a glass bottle body and a sealing member, the glass bottle body is formed with an inner cavity and a bottle mouth, the inner cavity is used to accommodate the freeze-dried standard sample and is used to accommodate the liquid standard sample formed by reconstituting the freeze-dried standard sample, and the bottle mouth is connected to the inner cavity so that at least a portion of the liquid standard sample can be sucked out of the inner cavity;

[0104] The sealing component is used to seal the bottle mouth, and the sealing component includes a bottle plug at least partially penetrated into the bottle mouth and / or a bottle cap at least partially sleeved outside the bottle mouth.

[0105] As an embodiment, the standard sample container has a bottle stopper and / or a bottle cap, the sample measuring device includes a pipetting mechanism, the pipetting mechanism includes a first pipetting needle, the first pipetting needle has a puncture function, and the first pipetting needle is at least used to puncture the bottle stopper and / or the bottle cap of the standard sample container to at least partially penetrate the standard sample container and absorb at least part of the liquid standard sample loaded therein and distribute it into the first reaction container; or,

[0106] The standard sample container has a bottle stopper, and the sample measuring device further comprises a pipetting mechanism and a de-stopper mechanism, wherein the de-stopper mechanism is used to remove the bottle stopper of the standard sample container, and the pipetting mechanism comprises a second pipetting needle, wherein the second pipetting needle does not have a puncture function, and the second pipetting needle is used to at least partially extend into the standard sample container after the bottle stopper is removed by the de-stopper mechanism, and absorb at least a part of the liquid standard sample loaded therein and distribute it into the first reaction container; or,

[0107] The standard sample container has a bottle stopper and a bottle cap, and the sample measuring device also includes a pipetting mechanism, a plugging mechanism and a capping mechanism. The capping mechanism is used to remove the bottle cap of the standard sample container, and the plugging mechanism is used to remove the bottle stopper of the standard sample container. The pipetting mechanism includes a second pipetting needle, and the second pipetting needle does not have a puncture function. The second pipetting needle is used to at least partially extend into the standard sample container after the bottle cap is removed by the capping mechanism and the bottle stopper is removed by the plugging mechanism, and to absorb at least a part of the liquid standard sample loaded therein and distribute it into the first reaction container.

[0108] As an embodiment, the standard sample container includes a first container and / or a second container, and the reconstitution device includes a storage mechanism, the storage mechanism is used for placing the first container loaded with the freeze-dried standard sample to achieve the loading of the freeze-dried standard sample, and the storage mechanism is used to store the first container loaded with at least part of the liquid standard sample formed by reconstitution of the freeze-dried standard sample, and / or for storing the second container loaded with at least part of the liquid standard sample;

[0109] The control of the transmission device to transmit the standard sample container output from the reconstitution device and loaded with at least a portion of the liquid standard sample to the sample measuring device includes: controlling the transmission device to transmit the first container output from the storage mechanism and loaded with at least a portion of the liquid standard sample to the sample measuring device, or controlling the transmission device to transmit the second container output from the storage mechanism and loaded with at least a portion of the liquid standard sample to the sample measuring device.

[0110] As an embodiment, the storage mechanism is also used for placing a third container loaded with a liquid standard sample to achieve loading of the liquid standard sample;

[0111] The control device is further configured to control the transport device to transport the third container output from the storage mechanism and loaded with the liquid standard sample to the sample measuring device.

[0112] As an embodiment, the reconstitution device further includes a reconstitution solution dispensing mechanism;

[0113] The sample analysis device further comprises a second information acquisition component, the second information acquisition component being used to acquire information of a container loaded with materials in the storage mechanism;

[0114] The control device is also configured to:

[0115] According to the information of the container fed back by the second information acquisition component, the type information of the standard sample loaded in the container loaded by the storage mechanism is obtained;

[0116] When the standard sample loaded in the container loaded by the storage mechanism is a freeze-dried standard sample, controlling the reconstitution solution dispensing mechanism to dispense the reconstitution solution into the container, so that the freeze-dried standard sample and the reconstitution solution are mixed in the container to form the liquid standard sample;

[0117] When the standard sample loaded in the container loaded by the storage mechanism is a liquid standard sample, the reconstitution solution dispensing mechanism is not controlled to dispense the reconstitution solution into the container.

[0118] As an embodiment, the freeze-dried standard sample is a freeze-dried quality control product, and the reference test data is quality control data;

[0119] Alternatively, the freeze-dried standard sample is a freeze-dried calibrator, and the reference detection data is calibration data.

[0120] As an embodiment, the freeze-dried standard sample is a freeze-dried quality control product, and the reference test data is quality control data;

[0121] The sample analysis device pre-stores at least one of the following first preset conditions: reaching a first preset time point of a first preset period, the cumulative running time of the sample measurement device since the last quality control item measurement reaches a first preset time, the number of times the sample measurement device continuously measures the sample to be measured reaches a first preset number of times, the number of times the sample measurement device cumulatively measures the sample to be measured reaches a second preset number of times since the last quality control item measurement, the reagent container is replaced to supply reagents, and the information on the execution of the quality control item is obtained according to the instructions input by the operator through the human-computer interaction device;

[0122] The control device is further configured to: when any one or more of the first preset conditions are met, control the transmission device to transmit the standard sample container output from the reconstitution device and loaded with at least part of the quality control product to the sample measurement device.

[0123] As an embodiment, the sample measuring device measures the liquid standard sample to obtain reference test data, including: the sample measuring device measures a first reaction liquid made of at least the liquid standard sample and a reagent to obtain the reference test data;

[0124] The sample measuring device measures the sample to be measured to obtain sample detection data, including: the sample measuring device measures a second reaction liquid prepared by at least the sample to be measured and the reagent to obtain the sample detection data.

[0125] As an embodiment, the reconstitution device is disposed outside the sample determination device;

[0126] And / or, the sample test data includes coagulation item test data of the sample to be tested.

[0127] A second object of the present invention is to provide a sample analysis device, the sample analysis device comprising:

[0128] A reconstitution device, wherein the reconstitution device is used to reconstitute the freeze-dried standard sample into a liquid standard sample;

[0129] A sample measuring device, the sample measuring device comprising a sample storage mechanism and a sample measuring mechanism, the sample storage mechanism is used to store a sample container loaded with a sample to be tested, and the sample measuring mechanism is used to measure at least part of the sample to be tested in the sample container from the sample storage mechanism to obtain sample detection data;

[0130] A transmission device, the transmission device is used to: transmit the standard sample container output by the reconstitution device and loaded with at least a part of the liquid standard sample formed by reconstitution of the freeze-dried standard sample to the sample storage mechanism;

[0131] A control device, wherein the control device is configured to: control the reconstitution device to reconstitute the freeze-dried standard sample into the liquid standard sample, control the transmission device to transmit the standard sample container output from the reconstitution device and loaded with at least a portion of the liquid standard sample to the sample storage mechanism, and control the sample measurement mechanism to measure at least a portion of the liquid standard sample in the standard sample container from the sample storage mechanism to obtain reference test data.

[0132] As an embodiment, controlling the transmission device to transmit the standard sample container output from the re-dissolving device and loaded with at least a portion of the liquid standard sample to the sample storage mechanism includes: controlling the transmission device to transmit a first sample rack output from the re-dissolving device and loaded with the standard sample container to the sample storage mechanism;

[0133] The sample storage mechanism is used to store the first sample rack from the transmission device and loaded with the standard sample container, and is used to store the second sample rack loaded with sample containers and the sample containers are loaded with the samples to be tested;

[0134] The first sample rack has at least two first placement positions, each of which is used to place a single standard sample container, and the second sample rack has at least two second placement positions, each of which is used to place a single sample container;

[0135] Preferably, the first sample rack and the second sample rack are two sample racks of the same shape and size.

[0136] As an embodiment, the reconstitution device is located outside the sample determination device;

[0137] And / or, the transmission device includes a transmission track, and the transmission track is used to carry the standard sample container output by the reconstitution device and loaded with at least a part of the liquid standard sample, and transmit it to the sample storage mechanism.

[0138] A third object of the present invention is to provide a sample analysis device, the sample analysis device comprising:

[0139] A reconstitution device, wherein the reconstitution device is used to reconstitute the freeze-dried standard sample into a liquid standard sample;

[0140] A sample measuring device, the sample measuring device is used to measure the sample to be measured to obtain sample test data, and is used to measure the liquid standard sample to obtain reference test data;

[0141] The sample measuring device comprises a sample scheduling mechanism, a liquid transfer mechanism and a sample measuring mechanism, wherein the sample scheduling mechanism is used to schedule a first sample rack so that the first sample rack drives a standard sample container loaded therein to be scheduled to a first sample suction position, wherein the standard sample container is loaded with at least a portion of the liquid standard sample formed by reconstituting the freeze-dried standard sample, the liquid transfer mechanism is used to draw at least a portion of the liquid standard sample loaded therein from the standard sample container located at the first sample suction position and distribute it to a first reaction container, and the sample measuring mechanism is used to measure a first reaction liquid in the first reaction container made of at least the liquid standard sample distributed to the first reaction container;

[0142] The first sample rack has at least two first placement positions, and each of the first placement positions is used to place a single standard sample container.

[0143] As an embodiment, the reconstitution device comprises:

[0144] a reconstitution solution dispensing mechanism, the reconstitution solution dispensing mechanism being used to dispense the reconstitution solution into the standard sample container loaded with the freeze-dried standard sample, so that the freeze-dried standard sample and the reconstitution solution are mixed to form the liquid standard sample;

[0145] a mixing mechanism, the mixing mechanism being used to mix the freeze-dried standard sample and the reconstitution solution in the standard sample container after the reconstitution solution dispensing mechanism dispenses the reconstitution solution into the standard sample container loaded with the freeze-dried standard sample;

[0146] Wherein, the rehydration solution dispensing mechanism and the pipetting mechanism are the same mechanism or two independent mechanisms.

[0147] As an implementation mode, the mixing mechanism is integrated with the re-solution dispensing mechanism;

[0148] Alternatively, the mixing mechanism and the re-solution dispensing mechanism are arranged independently of each other.

[0149] A fourth object of the present invention is to provide a sample analysis device, the sample analysis device comprising:

[0150] A reconstitution device, wherein the reconstitution device is used to reconstitute the freeze-dried standard sample into a liquid standard sample;

[0151] A sample measuring device, the sample measuring device is located outside the reconstitution device, the sample measuring device is used to measure the sample to be measured to obtain sample test data, and is used to measure the liquid standard sample to obtain reference test data;

[0152] A transmission device, the transmission device comprising a transmission track, the transmission track is used to carry the standard sample container output by the reconstitution device and loaded with at least a part of the liquid standard sample formed by reconstitution of the freeze-dried standard sample, and transmit it to the sample measurement device;

[0153] A control device, wherein the control device is configured to: control the reconstitution device to reconstitute the freeze-dried standard sample into the liquid standard sample, control the transmission track to transfer the standard sample container output from the reconstitution device and loaded with at least a portion of the liquid standard sample to the sample measurement device, and control the sample measurement device to measure a first reaction liquid made from at least a portion of the liquid standard sample transmitted from the transmission track to obtain the reference detection data.

[0154] As an embodiment, the standard sample container includes a first container and / or a second container, and the reconstitution device includes a storage mechanism, the storage mechanism is used for placing the first container loaded with the freeze-dried standard sample to realize the loading of the freeze-dried standard sample and for placing the third container loaded with the liquid standard sample to realize the loading of the liquid standard sample, and the storage mechanism is used to store the first container loaded with at least part of the liquid standard sample formed by reconstitution of the freeze-dried standard sample, and / or for storing the second container loaded with at least part of the liquid standard sample;

[0155] The transfer track is used to carry the first container loaded with at least a portion of the liquid standard sample formed by reconstituting the freeze-dried standard sample or the second container loaded with at least a portion of the liquid standard sample formed by reconstituting the freeze-dried standard sample to the sample storage mechanism, and to carry the third container loaded with the liquid standard sample to the sample storage mechanism.

[0156] As an embodiment, the control device is further configured to: control the transport track to carry the standard sample container output from the sample measuring device and after at least part of the liquid standard sample has been measured by the sample measuring device, and transport it to the reconstitution device for storage or recovery;

[0157] And / or, the re-dissolution device and the transfer track are respectively distributed on two adjacent sides of the sample determination device.

[0158] The sample analysis device provided by the present invention controls the reconstitution device to reconstitute the freeze-dried standard sample into a liquid standard sample through a control device, controls the transmission device to transmit the standard sample container output by the reconstitution device and loaded with at least a portion of the liquid standard sample formed by the reconstitution of the freeze-dried standard sample to the sample measurement device through the control device, and controls the sample measurement device to absorb at least a portion of the liquid standard sample from the standard sample container and distribute it to the first reaction container for measurement through the control device, thereby realizing automatic reconstitution of the freeze-dried standard sample in the sample analysis device and automatic measurement after reconstitution. In this way, the process of reconstitution of the freeze-dried standard sample into a liquid standard sample does not require human intervention, which on the one hand reduces the workload and operating burden of the operator during the standard sample measurement process, and on the other hand reduces the influence of human operating factors on the standard sample measurement results, thereby ensuring the accuracy and effectiveness of the standard sample measurement results. BRIEF DESCRIPTION OF THE DRAWINGS

[0159] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the structures shown in these drawings without paying creative work.

[0160] Figure 1 is a schematic diagram of the composition of a sample analysis device provided in Embodiment 1 of the present invention;

[0161] Figure 2 is a schematic diagram of the layout of a sample analysis device provided in Embodiment 1 of the present invention;

[0162] Figure 3 It is a schematic diagram of the layout of the sample analysis device provided in the first embodiment of the present invention in a manner that the loading area and the unloading area are separately arranged and the re-dissolving device is arranged close to the unloading area;

[0163] Figure 4 It is a schematic diagram of the layout of the sample analysis device provided by the first embodiment of the present invention in a manner that the loading area and the unloading area are separately arranged and the re-dissolving device is arranged close to the loading area;

[0164] Figure 5 It is a schematic diagram of the layout of the sample analysis device provided in the first embodiment of the present invention in a manner that the loading area and the unloading area are arranged adjacent to each other and close to the re-dissolution device;

[0165] Figure 6 is a schematic diagram of a sample analysis device provided in Embodiment 1 of the present invention, in which a loading area and an unloading area are arranged adjacent to each other and away from a reconstitution device;

[0166] Figure 7It is a schematic diagram of the layout of the sample analysis device provided by the first embodiment of the present invention in which the sample management device and the re-dissolution device are arranged on opposite sides of the sample measurement device;

[0167] Figure 8 is a schematic diagram of the composition of a sample measurement device provided in Embodiment 1 of the present invention;

[0168] Fig. 9 is a schematic diagram of the composition of the reconstitution device provided in Example 1 of the present invention;

[0169] Fig.10 is a schematic structural diagram of a first container provided in Embodiment 1 of the present invention;

[0170] Fig.11 is a schematic diagram of the freeze-dried standard sample provided in Example 1 of the present invention being reconstituted into a liquid standard sample in a first container;

[0171] Fig.12 It is a structural schematic diagram of a liquid standard sample provided by the first embodiment of the present invention being loaded into a sample rack through a first container;

[0172] Fig.13 is a schematic flow chart of a first standard sample determination working mode provided in Embodiment 1 of the present invention;

[0173] Fig.14 is a schematic flow chart of a second standard sample determination working mode provided in the first embodiment of the present invention;

[0174] Fig.15 is a schematic diagram of the composition of a re-dissolution device provided in Example 2 of the present invention;

[0175] Fig.16 is a schematic flow chart of the third standard sample determination working mode provided in the second embodiment of the present invention;

[0176] Fig.17 is a schematic diagram of the composition of a sample measurement device provided in Embodiment 3 of the present invention;

[0177] Fig.18 Schematic diagram of the principle of the decapping operation provided in the third embodiment of the present invention;

[0178] Fig.19 is a schematic diagram of the principle of the de-plugging operation provided in the third embodiment of the present invention;

[0179] Fig. 20 is a schematic diagram of the composition of a sample measurement device provided in a fourth embodiment of the present invention;

[0180] Fig.21 It is a schematic diagram of the structure in which the liquid standard sample provided by the fourth embodiment of the present invention is loaded into the sample rack through the first container.

[0181] Description of the accompanying drawings: 10, sample analysis equipment; 100, sample measurement device; 110, sample storage mechanism; 111, loading area; 112, unloading area; 113, buffer area; 120, sample scheduling mechanism; 130, sample distribution mechanism; 140, sample measurement mechanism; 141, incubation component; 142, measurement component; 150, reagent distribution mechanism; 151, mixed reagent dispensing mechanism; 152, trigger reagent dispensing mechanism; 160, reagent tray; 170, reaction container supply mechanism; 180, reaction container transport mechanism; 190, plug removal mechanism; 191, plug removal needle; 1911, hollow inner hole; 101, cover removal mechanism; 102, first clamping mechanism; 103, second clamping mechanism; 200, reconstitution device; 210, reconstitution solution dispensing mechanism; 220, mixing mechanism; 230, storage mechanism; 231, refrigeration mechanism; 232, freezing mechanism; 240, rewarming mechanism; 250, second transfer mechanism; 260, input and output device; 270, filling mechanism; 300, transmission device; 310, transmission track; 311, sample injection position; 312, entrance and exit; 400, control device; 500, second information acquisition component; 600, first information acquisition component; 700, sample management device; 20, first container; 21, glass bottle body; 22, sealing member; 2201, bottle stopper; 2202, bottle cap; 2203, through hole; 30, first sample rack; 40, freeze-dried standard sample; 50, liquid standard sample; X 1 , first direction; X 2 , the second direction. DETAILED DESCRIPTION

[0182] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0183] Embodiment 1:

[0184] like Figures 1 to 14As shown, the sample analysis device 10 provided in the first embodiment of the present invention includes a sample measuring device 100, a re-dissolving device 200 and a transmission device 300. The sample measuring device 100 is used to measure the sample to be tested to obtain sample test data, and is used to measure the liquid standard sample 50 to obtain reference test data. The re-dissolving device 200 is used to re-dissolve the freeze-dried standard sample 40 into a liquid standard sample 50. The transmission device 300 is used to transmit the liquid standard sample 50 output from the re-dissolving device 200 to the sample measuring device 100. Among them, the sample to be tested is a sample collected from a human body or an animal. The freeze-dried standard sample is prepared by a freeze-drying process from a liquid standard sample 50 of known concentration (i.e., a liquid standard sample 50 of known target concentration, which is the same as the target of all tests of the sample to be tested). In this embodiment, the automatic reconstitution of the freeze-dried standard sample 40 is achieved through the setting of the reconstitution device 200; the automatic transmission of the liquid standard sample 50 formed by the reconstitution is achieved through the transmission device 300; the measurement of the liquid standard sample 50 is achieved through the sample measurement device 10, so that the freeze-dried standard sample 40 can be directly loaded onto the sample analysis device 10, and the automatic reconstitution of the freeze-dried standard sample 40 after loading and the automatic measurement after reconstitution in the sample analysis device 10 are achieved. In this way, on the one hand, the workload and operating burden of the operator in the standard sample measurement process are reduced, and on the other hand, the influence of human operating factors on the results of the standard sample measurement items is reduced, thereby ensuring the accuracy and effectiveness of the measurement results of the standard sample measurement items.

[0185] Reference Figure 1 , Figure 2 and Figure 3 As shown, as an embodiment, the sample analysis device 10 also includes a control device 400, which is electrically connected to at least one of the sample measuring device 100, the re-dissolving device 200 and the transmission device 300, so as to control the operation of at least one of the sample measuring device 100, the re-dissolving device 200 and the transmission device 300.

[0186] As an implementation manner, the control device 400 is electrically connected to the sample measuring device 100 , the reconstitution device 200 , and the transmission device 300 , respectively, so as to control the operation of the sample measuring device 100 , the reconstitution device 200 , and the transmission device 300 .

[0187] As an embodiment, the control device 400 is configured to control the reconstitution device 200 to reconstitute the freeze-dried standard sample 40 into a liquid standard sample 50. In this embodiment, the reconstitution device 200 automatically reconstitutes the freeze-dried standard sample 40 into a liquid standard sample 50 under the control of the control device 400, and the reconstitution process does not require human intervention, which helps to reduce the burden on the operator and reduces the impact of human operation factors on the standard sample measurement results.

[0188] As an embodiment, the control device 400 is further configured to control the transmission device 300 to transmit at least part of the liquid standard sample 50 output from the reconstitution device 200 and formed by reconstitution of the freeze-dried standard sample 40 to the sample measurement device 100. Under the control of the control device 400, the transmission device 300 automatically transmits the liquid standard sample 50 formed by reconstitution of the freeze-dried standard sample 40 to the sample measurement device 100 for measurement, and the transmission process does not require manual participation, which helps to reduce the burden on operators.

[0189] As an embodiment, the transmission device 300 transmits the liquid standard sample 50 output from the reconstitution device 200 to the sample measuring device 100, including: the transmission device 300 transmits the standard sample container output from the reconstitution device 200 and loaded with at least a portion of the liquid standard sample 50 formed by reconstitution of the freeze-dried standard sample 40 to the sample measuring device 100. The standard sample container is a container for loading standard samples. In this embodiment, the transmission device 300 transmits at least a portion of the liquid standard sample 50 from the reconstitution device 200 and formed by reconstitution of the freeze-dried standard sample 40 to the sample measuring device 100 through the standard sample container, that is, the liquid standard sample 50 is transmitted using the standard sample container as a carrier, thereby achieving the purpose of transmitting the liquid standard sample 50 to the sample measuring device 100, and helping to avoid the undesirable phenomenon of the liquid standard sample 50 being contaminated during the transmission process.

[0190] As an embodiment, the control device 400 is configured to: control the reconstitution device 200 to reconstitute the freeze-dried standard sample 40 into a liquid standard sample 50, control the transmission device 300 to transmit the standard sample container output from the reconstitution device 200 and loaded with at least part of the liquid standard sample 50 to the sample measurement device 100, control the sample measurement device 100 to draw at least part of the liquid standard sample 50 loaded in the standard sample container from the standard sample container and distribute it to the first reaction container, and control the sample measurement device 100 to measure the first reaction liquid in the first reaction container made of at least the liquid standard sample 50 distributed to the first reaction container to obtain reference detection data. In this embodiment, after the liquid standard sample 50 is transmitted to the sample measurement device 100, it needs to be transferred to the first reaction container for measurement, rather than being measured directly in the standard sample container. This is conducive to reducing the quantitative requirements of the liquid standard sample 50 in the standard sample container and facilitating multiple uses of the liquid standard sample 50 in the standard sample container. In this embodiment, the control device 400 controls the reconstitution device 200 to reconstitute the freeze-dried standard sample 40 into a liquid standard sample 50, and the control device 400 controls the transmission device 300 to transmit the standard sample container output by the reconstitution device 200 and loaded with at least a portion of the liquid standard sample 50 formed by the reconstitution of the freeze-dried standard sample 40 to the sample measurement device 100, and the control device 400 controls the sample measurement device 100 to absorb at least a portion of the liquid standard sample 50 from the standard sample container and distribute it to the first reaction container for measurement, thereby realizing the automatic reconstitution of the freeze-dried standard sample 40 in the sample analysis device 10 and the automatic measurement after reconstitution. In this way, the process of reconstitution of the freeze-dried standard sample 40 into the liquid standard sample 50 does not require human participation, which on the one hand reduces the workload and operating burden of the operator during the standard sample measurement process, and on the other hand reduces the influence of human operating factors on the standard sample measurement results, thereby ensuring the accuracy and effectiveness of the standard sample measurement results.

[0191] As an embodiment, the freeze-dried standard sample 40 is a freeze-dried quality control product, the liquid standard sample 50 is a liquid quality control product, and the reference detection data is the quality control data. Specifically, the freeze-dried quality control product is prepared by a freeze-drying process from a liquid quality control product of a known concentration. The liquid quality control product is used to perform the determination of the quality control items of the sample analysis device 10. By comparing and evaluating the actual measured results of the liquid quality control product in the sample analysis device 10 and the known results (i.e., target values) preset in the sample analysis device 10, it can be confirmed whether the sample analysis device 10 is in a normal state. Of course, in specific applications, the freeze-dried standard sample 40 is not limited to the freeze-dried quality control product. For example, as an alternative embodiment, the freeze-dried standard sample 40 is a freeze-dried calibrator, the liquid standard sample 50 is a liquid calibrator, and the reference detection data is the calibration data. The freeze-dried calibrator is prepared by a freeze-drying process from a liquid calibrator of a known concentration. The liquid calibrator is used to calibrate each sample determination item of the sample analysis device 10.

[0192] As an embodiment, the sample measuring device 100 measures the liquid standard sample 50 to obtain reference test data, including: the sample measuring device 100 measures a first reaction liquid made of at least the liquid standard sample 50 and a reagent to obtain reference test data. The sample measuring device 100 measures the sample to be tested to obtain sample test data, including: the sample measuring device 100 measures a second reaction liquid made of at least the sample to be tested and a reagent to obtain sample test data. In this embodiment, the sample measuring device 100 needs to mix with a reagent to prepare a reaction liquid for both the measurement of the liquid standard sample 50 and the measurement of the sample to be tested, and the reagent used in the measurement of the liquid standard sample 50 and the reagent used in the measurement of the sample to be tested are the same reagent. It should be noted that the reagent used in the measurement of the liquid standard sample 50 and the reagent used in the measurement of the sample to be tested are the same reagent, which is for the measurement of the liquid standard sample 50 and the measurement of the sample to be tested of the same type of project, that is, under the premise that the target object measured by the liquid standard sample 50 and the target object measured by the sample to be tested are the same substance.

[0193] As an embodiment, the control device 400 is also configured to: when the first preset condition is met, the control transmission device 300 will transfer the standard sample container output from the re-dissolving device 200 and loaded with the liquid standard sample 50 to the sample measuring device 100. That is: the above-mentioned control transmission device 300 will transfer the standard sample container output from the re-dissolving device 200 and loaded with at least part of the liquid standard sample 50 to the sample measuring device 100, including: when the first preset condition is met, the control transmission device 300 will transfer the standard sample container output from the re-dissolving device 200 and loaded with the liquid standard sample 50 to the sample measuring device 100. The first preset condition is a condition pre-stored in the sample analysis device 10 for triggering the control device 400 to automatically control the execution of the standard sample measurement project. In this embodiment, the control device 400 automatically triggers the execution of the standard sample measurement project according to the pre-stored first preset condition, without manual participation in the triggering, which is conducive to reducing the workload of the operator. Of course, in a specific application, as an alternative embodiment, the standard sample measurement project can also be set to a method that can be manually triggered for execution.

[0194] As an embodiment, when the freeze-dried standard sample 40 is a freeze-dried quality control product, and the reference test data is quality control data. The sample analysis device 10 pre-stores at least one of the following first preset conditions: reaching the first preset time point of the first preset cycle, the cumulative running time of the sample measurement device 100 since the last quality control item measurement reaches the first preset time, the number of times the sample measurement device 100 continuously measures the sample to be tested reaches the first preset number of times, the number of times the sample measurement device 100 cumulatively measures the sample to be tested since the last quality control item measurement reaches the second preset number of times, the reagent container is replaced to supply reagents, and the information on the execution of the quality control item is obtained according to the instructions input by the operator through the human-computer interaction device. The control device 400 is configured as follows: when any one or more of the first preset conditions are met, the control transmission device 300 will transfer the standard sample container output from the re-dissolution device 200 and loaded with at least part of the liquid quality control product to the sample measurement device 100. The first preset condition pre-stored in the sample analysis device 10 may be one or more than two; when the first preset condition pre-stored in the sample analysis device 10 is more than two, when any of the first preset conditions is met, the control device 400 controls the transmission device 300 to transmit the liquid standard sample 50 from the re-dissolving device 200 to the sample measurement device 100 to execute the quality control project. In this embodiment, the execution of the quality control project does not occupy the time of the sample measurement cycle, and when the first preset condition is met, it is automatically executed according to the set program, which is conducive to making the operator basically unaware of the execution process of the quality control project, and greatly reducing the interference of the quality control measurement process on the operator.

[0195] As an implementation mode, the first preset period is every day. The first preset time point of the first preset period is 7:00 a.m. every day, 7:30 a.m. every day, 8:00 a.m. every day, 8:30 a.m. every day, 9:00 a.m. every day, or 9:30 a.m. every day. Of course, in specific applications, the setting method of the first preset time point of the first preset period is not limited to this, and can be flexibly set according to the use of the sample analysis device 10 in a specific application scenario, for example, it can also be two days, three days, four days, five days, six days, or one week.

[0196] As an alternative to the above-mentioned freeze-dried standard sample 40 being a freeze-dried quality control product, the freeze-dried standard sample 40 is a freeze-dried calibrator, and the reference test data is calibration data. The sample analysis device 10 pre-stores at least one of the following fourth preset conditions: reaching a second preset time since the last execution of the project calibration process; reaching a second preset time point of the second preset cycle; obtaining information about a newly loaded reagent container; obtaining information about an error in the quality control measurement result, and obtaining information about executing the calibration project according to instructions input by the operator through the human-computer interaction device. The control device 400 is configured to: when any one or more of the fourth preset conditions are met, the control transmission device 300 will transfer the standard sample container output from the re-dissolution device 200 and loaded with at least part of the liquid calibrator to the sample measurement device 100. The fourth preset condition pre-stored in the sample analysis device 10 may be one or more than two; when the fourth preset condition pre-stored in the sample analysis device 10 is more than two, when any of the fourth preset conditions is met, the control device 400 controls the transmission device 300 to transmit the liquid calibrant from the re-dissolving device 200 to the sample measurement device 100 to execute the calibration project. In this embodiment, the execution of the calibration project does not occupy the time of the sample measurement cycle, and when the fourth preset condition is met, it is automatically executed according to the set program, which is conducive to making the operator basically unaware of the execution process of the calibration project, and greatly reducing the interference of the project calibration process on the operator.

[0197] Reference Figures 2 to 7 As shown, as an embodiment, the re-dissolving device 200 is arranged outside the sample measuring device 100, that is, the re-dissolving device 200 and the sample measuring device 100 are two independent devices. In this embodiment, the re-dissolving device 200 is arranged outside the sample measuring device 100, so that the arrangement of the re-dissolving device 200 does not affect the structure and internal layout of the sample measuring device 100. The re-dissolving device 200 and the sample measuring device 100 are assembled as two independent modules, and the re-dissolving device 200 can be quickly removed or added as needed. Of course, in a specific application, as an alternative embodiment, the re-dissolving device 200 can also be arranged in the sample measuring device 100.

[0198] Reference Figures 3 to 7As shown, as an embodiment, the transmission device 300 includes a transmission track 310. The reconstitution device 200 and the sample determination device 100 are respectively connected to and interact with the transmission track 310. The connection and interaction here do not necessarily require a physical contact relationship, and there may also be a certain gap. Of course, in specific applications, the transmission device 300 is not limited to the scheme of using the transmission track 310. For example, a scheme of robot transmission or a scheme of combining the transmission track 310 with a robot may also be adopted.

[0199] As an embodiment, the freeze-dried standard sample 40 is a solid standard sample made by a vacuum freezing and lyophilizing process. Vacuum freezing and lyophilizing is a freeze-drying technology that uses the principle of sublimation to dehydrate materials. Specifically, vacuum freezing and lyophilizing technology is a freeze-drying method that freezes water-containing materials into solids and uses the sublimation properties of water under low temperature and low pressure conditions to dehydrate the materials at low temperatures to achieve freeze-drying. Since vacuum freezing and lyophilizing technology is carried out in a low temperature and low oxygen environment, most biological reactions stagnate, and there is no liquid water in the treatment process. The water is directly sublimated in a solid state, so that the original structure and shape of the material are protected to the greatest extent, and finally a high-quality freeze-dried product with both appearance and intrinsic quality is obtained.

[0200] As an embodiment, the standard sample container includes a first container 20. The above-mentioned control of the reconstitution device 200 to reconstitute the freeze-dried standard sample 40 into a liquid standard sample 50 includes: controlling the reconstitution device 200 to reconstitute the freeze-dried standard sample 40 in the first container 20 into a liquid standard sample 50. The above-mentioned control of the transmission device 300 to transmit the standard sample container output from the reconstitution device 200 and loaded with at least part of the liquid standard sample 50 to the sample measurement device 100 includes: controlling the transmission device 300 to transmit the first container 20 output from the reconstitution device 200 and loaded with the liquid standard sample 50 to the sample measurement device 100. The above-mentioned control of the sample measurement device 100 to absorb at least part of the liquid standard sample 50 loaded therein from the standard sample container and distribute it to the first reaction container includes: controlling the sample measurement device 100 to absorb at least part of the liquid standard sample 50 loaded therein from the first container 20 and distribute it to the first reaction container. In the present embodiment, after the freeze-dried standard sample 40 is reconstituted, there is no need to repackage it. The first container 20 originally used to load the freeze-dried standard sample 40 is directly used as the container for carrying the liquid standard sample 50 and transferred from the reconstitution device 200 to the sample measuring device 100. That is, the original container of the freeze-dried standard sample 40 is directly used to transfer the liquid standard sample 50 to the sample measuring device 100, which can save the time for repackaging the liquid standard sample 50, thereby helping to reduce the occupation time of the standard sample project.

[0201] Reference Fig.10 and Fig.11As shown, as an embodiment, the standard sample container includes a glass bottle body 21 and a sealing member 22. Take the first container 20 as an example of a standard sample container. The first container 20 includes a glass bottle body 21 and a sealing member 22. The glass bottle body 21 is formed with an inner cavity and a bottle mouth. The inner cavity is used to accommodate the freeze-dried standard sample 40 and to accommodate the liquid standard sample 50 formed by the reconstitution of the freeze-dried standard sample 40, that is, the inner cavity is used to provide a place for accommodating the freeze-dried standard sample 40 and the liquid standard sample 50. The bottle mouth is connected to the inner cavity to at least allow the liquid standard sample 50 to enter and exit the inner cavity. In a specific application, the bottle mouth is used to at least allow at least part of the liquid standard sample 50 to be sucked out of the inner cavity. The sealing member 22 is used to seal the bottle mouth. The glass bottle body 21 can block moisture and oxygen, thereby extending the shelf life of the freeze-dried standard sample 40, and the size of the glass bottle body 21 is also ideal for the high-density freeze-dried standard sample 40. The glass bottle body 21 is a packaging form with better cost-effectiveness for the freeze-dried standard sample 40.

[0202] Reference Fig.10 and Fig.11 As shown in the figure, as an embodiment, the sealing member 22 includes a bottle plug 2201 at least partially inserted into the bottle mouth and / or a bottle cap 2202 at least partially sleeved outside the bottle mouth. The bottle mouth can be double-sealed by the bottle plug 2201 and the bottle cap 2202. Of course, in a specific application, as an alternative embodiment, the sealing member 22 can also include only one of the bottle plug 2201 and the bottle cap 2202.

[0203] As an embodiment, the sample measuring device 100 includes a pipetting mechanism (the pipetting mechanism and the sample dispensing mechanism 130 in the figure are the same mechanism. Of course, in specific applications, the pipetting mechanism and the sample dispensing mechanism 130 may also be different mechanisms), and the pipetting mechanism includes a first pipetting needle, and the first pipetting needle has a puncture function. The first pipetting needle is at least used to puncture the bottle stopper 2201 and / or the bottle cap 2202 of the standard sample container to at least partially penetrate the standard sample container and absorb at least part of the liquid standard sample 50 loaded therein and distribute it into the first reaction container. In this embodiment, the first pipetting needle is a puncture needle, which can puncture the bottle stopper 2201 and / or the bottle cap 2202 to aspirate liquid. The liquid standard sample 50 loaded in the standard sample container and reconstituted can be directly measured on the machine without removing the bottle stopper 2201 and / or bottle cap 2202 of the standard sample container. The liquid standard sample 50 can be directly absorbed from the standard sample container by a puncture needle directly penetrating the bottle cap 2202 and the bottle stopper 2201, thereby making the measurement of the standard sample more convenient and helping to reduce the contact between the liquid standard sample 50 and the air, thereby making the performance of the liquid standard sample 50 more stable.

[0204] As an embodiment, the first pipette needle is also used to distribute the sample to be tested and / or the reagent, that is: the distribution of the liquid standard sample 50 and the distribution of the sample to be tested may share the pipette needle, or the distribution of the liquid standard sample 50 and the distribution of the sample to be tested may not share the pipette needle; or the distribution of the liquid standard sample 50 and the distribution of the reagent may share the pipette needle, or the distribution of the liquid standard sample 50 and the distribution of the reagent may not share the pipette needle.

[0205] As an embodiment, the pipetting mechanism is also used to distribute the sample to be tested, that is, the pipetting mechanism is a sample distribution mechanism 130, the pipetting mechanism and the sample distribution mechanism 130 are the same mechanism, and the sample distribution mechanism 130 is used for the distribution of the liquid standard sample 50 and the distribution of the sample to be tested in a time-sharing manner. The first pipetting needle is a sample needle. The pipetting mechanism is also used to draw at least a portion of the sample to be tested loaded in the sample container and distribute it to the second reaction container. Of course, in a specific application, as an alternative embodiment, the pipetting mechanism and the sample distribution mechanism 130 can also be two independent mechanisms; or, the pipetting mechanism and the reagent distribution mechanism 150 are the same mechanism; or, the pipetting mechanism, the sample distribution mechanism 130, and the reagent distribution mechanism 150 are the same mechanism or three independent mechanisms.

[0206] As an embodiment, the bottle stopper 2201 includes a stopper body and a stopper cap. The stopper body is inserted into the bottle mouth. The stopper cap is connected to one end of the stopper body. The outer diameter of the stopper cap is larger than the inner diameter of the bottle mouth. The stopper cap abuts against the top end surface of the glass bottle body 21.

[0207] As an embodiment, the plug body includes a first extension section and a second extension section, the second extension section is connected between the first extension section and the plug cap along the axial direction of the plug body, wherein the outer wall of the first extension section is provided with an exhaust groove extending along the axial direction of the plug body. During the freeze-drying process of the standard sample, the water in the standard sample will undergo a sublimation process from freezing to gasification and discharge. Specifically, in the initial period of freeze-drying, the first extension section is partially penetrated into the bottle mouth, and the plug cap does not abut the top end surface of the glass bottle body 21. During the freeze-drying process, the gas inside the glass bottle body 21 is discharged from the exhaust groove to the outside of the glass bottle body 21, and the air pressure inside the glass bottle body 21 gradually decreases. The plug body will gradually and automatically penetrate into the bottle mouth until the plug cap abuts the top end surface of the glass bottle body 21.

[0208] Reference Figure 1 , Fig.10 and Fig.11 As shown, as an embodiment, the top wall of the bottle cap 2202 is provided with a through hole 2203, and the through hole 2203 is used to avoid the first pipette needle. When the first pipette needle absorbs the liquid standard sample 50 from the first container 20, the first pipette needle is aligned with the through hole 2203, and then the first pipette needle passes through the through hole 2203 and penetrates the plug cap and plug body of the bottle plug 2201 to enter the glass bottle body 21 to absorb liquid.

[0209] As an embodiment, the outer diameter of the glass bottle body 21 is in the range of 12 mm to 13 mm. In this embodiment, by setting the outer diameter of the glass bottle body 21 in the range of 12 mm to 13 mm, the first container 20 can be adapted to the size of the placement position of the sample rack or the sample seat. After the freeze-dried standard sample 40 is reconstituted in the first container 20, it can be directly placed in the sample rack or the sample seat for sample loading and testing, that is, there is no need to perform the subpackaging operation after reconstitution, thereby saving the time of standard sample determination and improving the efficiency of standard sample determination.

[0210] As an embodiment, the height of the glass bottle body 21 is greater than or equal to 30 mm.

[0211] As an embodiment, the total height of the first container 20 is greater than or equal to 40 mm.

[0212] As an embodiment, based on consideration of the freeze-drying process, the total height of the first container 20 is smaller than the height of the sample container.

[0213] Reference Fig. 9 and Fig.11 As shown, as an embodiment, the reconstitution device 200 includes a reconstitution solution dispensing mechanism 210; the reconstitution solution dispensing mechanism 210 is used to dispense the reconstitution solution into the standard sample container loaded with the freeze-dried standard sample 40, so that the freeze-dried standard sample 40 and the reconstitution solution are mixed to form a liquid standard sample 50. The above-mentioned control of the reconstitution device 200 to reconstitute the freeze-dried standard sample 40 into a liquid standard sample 50 includes: controlling the reconstitution solution dispensing mechanism 210 to dispense the reconstitution solution into the freeze-dried standard sample 40, so that the freeze-dried standard sample 40 and the reconstitution solution are mixed to form a liquid standard sample 50. In this embodiment, the freeze-dried standard sample 40 is reconstituted by dispensing the reconstitution solution, thereby realizing automatic reconstitution of the freeze-dried standard sample 40, and the reconstitution method is simple and easy to implement.

[0214] Specifically, the control of the reconstitution device 200 to reconstitute the lyophilized standard sample 40 in the first container 20 into the liquid standard sample 50 includes: controlling the reconstitution solution dispensing mechanism 210 to dispense the reconstitution solution into the lyophilized standard sample 40 in the first container 20, so that the lyophilized standard sample 40 and the reconstitution solution are mixed to form the liquid standard sample 50. Specifically, the reconstitution solution dispensing mechanism 210 dispenses the reconstitution solution into the first container 20 loaded with the lyophilized standard sample 40, so that the lyophilized standard sample 40 in the first container 20 and the reconstitution solution are mixed to form the liquid standard sample 50.

[0215] As an embodiment, the above-mentioned reconstitution solution dispensing mechanism 210 and the above-mentioned pipetting mechanism are two independent mechanisms. The reconstitution solution dispensing mechanism 210 includes a third pipetting needle, and the third pipetting needle is used to dispense the reconstitution solution into the standard sample container. The first pipetting needle and the third pipetting needle are two different pipetting needles, that is, the first pipetting needle and the third pipetting needle are two pipetting needles with different functions, rather than the same pipetting needle. The shape and size of the first pipetting needle and the third pipetting needle can be the same or different. In this embodiment, two pipetting needles are used to dispense the reconstitution solution into the standard sample container and to distribute the liquid standard sample 50 from the standard sample container to the first reaction container, that is, the distribution of the reconstitution solution and the distribution of the liquid standard sample 50 do not share the same pipetting needle, so that the distribution of the reconstitution solution and the distribution of the liquid standard sample 50 can be carried out in parallel, thereby helping to improve the working efficiency of the sample analysis device 10. Of course, in specific applications, as an alternative implementation, the reconstitution solution dispensing mechanism 210 and the pipetting mechanism can also be set as the same mechanism. In this alternative implementation, the distribution of the reconstitution solution and the distribution of the liquid standard sample 50 share the same pipetting needle, that is, the same pipetting needle is used to dispense the reconstitution solution into the standard sample container and to distribute the liquid standard sample 50 from the standard sample container to the first reaction container.

[0216] Reference Figure 1 , Fig. 9 and Fig.11 As shown, as an embodiment, the reconstitution device 200 further includes a mixing mechanism 220, and the mixing mechanism 220 is used to mix the freeze-dried standard sample 40 and the reconstitution solution in the standard sample container after the reconstitution solution dispensing mechanism 210 dispenses the reconstitution solution into the standard sample container loaded with the freeze-dried standard sample 40. Specifically, the control device 400 is also configured to: after controlling the reconstitution solution dispensing mechanism 210 to dispense the reconstitution solution into the first container 20 loaded with the freeze-dried standard sample 40, control the mixing mechanism 220 to mix the freeze-dried standard sample 40 and the reconstitution solution in the first container 20. The mixing operation of the mixing mechanism 220 can accelerate the dissolution of the freeze-dried standard sample 40 and promote its uniform concentration distribution, thereby facilitating the reconstitution speed of the freeze-dried standard sample 40 and ensuring the adequacy and efficiency of the reconstitution.

[0217] As an implementation mode, the mixing mechanism 220 is integrally provided with the re-solution dispensing mechanism 210, that is, the mixing mechanism 220 can be integrated with the re-solution dispensing mechanism 210. In this implementation mode, the mixing mechanism 220 can be integrated with the re-solution dispensing mechanism 210, which is beneficial to improve the compactness of the structure of the sample analysis device 10. Of course, in a specific application, as an alternative implementation mode, the mixing mechanism 220 and the re-solution dispensing mechanism 210 can also be separately provided, that is, the mixing mechanism 220 and the re-solution dispensing mechanism 210 can also be independently provided.

[0218] As an embodiment, the mixing mechanism 220 mixes the freeze-dried standard sample 40 and the reconstituted solution in the first container 20 by at least one of shaking, vibrating, stirring, ultrasonic, suction and exhalation, and bubble blowing. When the mixing mechanism 220 mixes the freeze-dried standard sample 40 and the reconstituted solution in the first container 20 by shaking, the mixing mechanism 220 includes a manipulator for grabbing the first container 20 for shaking; when the mixing mechanism 220 mixes the freeze-dried standard sample 40 and the reconstituted solution in the first container 20 by suction and exhalation, the mixing mechanism 220 includes a pipette needle for suctioning and exhaling liquid from the first container 20.

[0219] Reference Fig. 9 and Fig.11 As shown, as an embodiment, the reconstitution device 200 further includes a storage mechanism 230, which is used for placing the first container 20 loaded with the freeze-dried standard sample 40 to achieve the loading of the freeze-dried standard sample 40 and for storing the container loaded with the liquid standard sample 50 reconstituted by the freeze-dried standard sample 40. The above-mentioned control transmission device 300 transmits at least part of the liquid standard sample 50 output from the reconstitution device 200 and reconstituted by the freeze-dried standard sample 40 to the sample measurement device 100, including: controlling the transmission device 300 to transmit the container output from the reconstitution device 200 and loaded with at least part of the liquid standard sample 50 reconstituted by the freeze-dried standard sample 40 to the sample measurement device 100. Specifically, the storage mechanism 230 is used to store the first container 20 loaded with the freeze-dried standard sample 40 to load the freeze-dried standard sample 40, and is also used to store the first container 20 loaded with at least a portion of the liquid standard sample 50 formed by re-dissolving the freeze-dried standard sample 40; the above-mentioned control transmission device 300 transfers the standard sample container output from the re-dissolving device 200 and loaded with at least a portion of the liquid standard sample 50 to the sample measuring device 100, including: controlling the transmission device 300 to transfer the first container 20 output from the storage mechanism 230 and loaded with at least a portion of the liquid standard sample 50 to the sample measuring device 100. In this embodiment, the original container of the freeze-dried standard sample 40 is allowed to be directly loaded on the machine, and the freeze-dried standard sample 40 can be automatically re-dissolved after entering the sample analysis device 10.

[0220] As an embodiment, the storage mechanism 230 includes a refrigeration mechanism 231. The refrigeration mechanism 231 is used to store the liquid standard sample 50 and the freeze-dried standard sample 40.

[0221] As an embodiment, the storage mechanism 230 also includes a freezing mechanism 232. The freezing mechanism 232 can be used to freeze and store the liquid standard sample 50 to extend the validity period of the liquid standard sample 50. Of course, the freezing mechanism 232 can also be used to freeze and store the freeze-dried standard sample 40. In this embodiment, the storage mechanism 230 includes a refrigerating mechanism 231 and a freezing mechanism 232. Of course, in a specific application, as an alternative embodiment, the storage mechanism 230 can also include only one of the refrigerating mechanism 231 and the freezing mechanism 232.

[0222] Reference Fig. 9 and Fig.11 As shown, as an embodiment, the reconstitution device 200 further includes a rewarming mechanism 240 and a second transfer mechanism 250, and the storage mechanism 230 includes a refrigerating mechanism 231 and / or a freezing mechanism 232, and the storage temperature of the freezing mechanism 232 is lower than the storage temperature of the refrigerating mechanism 231. Both the refrigerating mechanism 231 and the freezing mechanism 232 have a refrigeration function, so as to ensure the validity period of the standard sample stored in the reconstitution device 200. The second transfer mechanism 250 is used to transfer the liquid standard sample 50 in the refrigerating mechanism 231 and / or the freezing mechanism 232 to the rewarming mechanism 240 for temperature increase.

[0223] As an embodiment, the mixing mechanism 220 may be integrated with the re-solution dispensing mechanism 210 or the second transfer mechanism 250 , or the mixing mechanism 220 may be independently provided from the re-solution dispensing mechanism 210 and the second transfer mechanism 250 .

[0224] As an embodiment, the storage mechanism 230 is also used for placing a third container loaded with a liquid standard sample 50 to achieve the loading of the liquid standard sample 50. The control device 400 is also configured to control the transmission device 300 to transfer the third container output from the storage mechanism 230 and loaded with the liquid standard sample 50 to the sample measurement device 100. The third container loaded with the liquid standard sample 50 is a standard sample container after redissolution offline (i.e., outside the sample analysis device 10). After the third container loaded with the liquid standard sample 50 is placed in the redissolution device 200, no redissolution operation is required. This embodiment allows both the freeze-dried standard sample 40 and the liquid standard sample 50 to be directly loaded on the machine, which is conducive to meeting the loading requirements of standard samples of different forms.

[0225] Reference Figure 1 , Fig. 9 and Fig.11As shown, as an embodiment, the sample analysis device 10 further includes a second information acquisition component 500, which is used to acquire information of the container loaded in the storage mechanism 230. The control device 400 is further configured to: obtain type information of the standard sample loaded in the container loaded in the storage mechanism 230 according to the information of the container fed back by the second information acquisition component 500; when the standard sample loaded in the container loaded in the storage mechanism 230 is a freeze-dried standard sample 40, control the reconstitution solution dispensing mechanism 210 to dispense the reconstitution solution into the container, so that the freeze-dried standard sample 40 and the reconstitution solution are mixed in the container to form a liquid standard sample 50; when the standard sample loaded in the container loaded in the storage mechanism 230 is a liquid standard sample 50, do not control the reconstitution solution dispensing mechanism 210 to dispense the reconstitution solution into the container. That is, the control device 400 is further configured to: obtain type information of the standard sample loaded in the storage mechanism 230 according to the information of the container fed back by the second information acquisition component 500, and determine whether it is necessary to perform a reconstitution operation on the loaded standard sample according to the type information of the standard sample. The type information of the standard sample includes: the standard sample loaded in the storage mechanism 230 is a freeze-dried standard sample 40, and the standard sample loaded in the storage mechanism 230 is a liquid standard sample 50. In this embodiment, the control device 400 automatically determines whether the loaded standard sample is a freeze-dried standard sample 40 or a liquid standard sample 50 through the feedback information of the second information acquisition component 500, so as to facilitate the reconstitution device 200 to take different treatment measures for the standard samples of different forms loaded on the machine. For example, if the loaded standard sample is a freeze-dried standard sample 40, it is necessary to add a reconstitution solution for reconstitution before the standard sample can be measured; and if the loaded freeze-dried standard sample 40 is a liquid standard sample 50, it is not necessary to add a reconstitution solution for reconstitution, and the standard sample can be directly measured.

[0226] As an embodiment, the second information acquisition component 500 includes an identification component, which is used to identify the structural characteristics and / or identification code of the container loaded on the storage mechanism 230. The control device 400 is also configured to obtain the type information of the standard sample loaded on the storage mechanism 230 according to the structural characteristics and / or identification code of the container loaded on the storage mechanism 230. In this embodiment, the control device 400 automatically identifies the type of the standard sample loaded on the storage mechanism 230 through the identification component, without the need for manual operation by the operator. Of course, in specific applications, the way in which the control device 400 obtains the type information of the standard sample is not limited to this. For example, as an alternative embodiment, the second information acquisition component 500 includes a human-computer interaction device, which is used for the operator to manually enter or select the type of the standard sample loaded on the storage mechanism 230. In this alternative embodiment, the type information of the standard sample is manually entered; as another alternative embodiment, the sample analysis device 10 can also have the functions of automatically identifying the type information of the standard sample and manually entering the type information of the standard sample, that is, the second information acquisition component 500 includes both the identification component and the human-computer interaction device.

[0227] As an embodiment, the identification component includes at least one of a visual camera, a barcode scanner, a two-dimensional code scanner, and a wireless radio frequency code reader.

[0228] Reference Figure 1 , Figure 2 and Fig. 9 As shown, as an embodiment, the reconstitution device 200 further includes an input / output device 260, which is used for inputting the freeze-dried standard sample 40 and outputting the liquid standard sample 50, and the input / output device 260 is connected and interacts with the transmission track 310 of the transmission device 300. After the liquid standard sample is output, it is transmitted to the sample measurement device 100 through the transmission track 310 of the transmission device 300 for measurement. Of course, in specific applications, the reconstitution device 200 may also not include the input / output device 260.

[0229] As an embodiment, the control device 400 is further configured to: control the transmission device 300 to transmit the standard sample container output from the sample measuring device 100 and after the sample measuring device 100 absorbs and distributes the liquid standard sample 50 to the re-dissolving device 200 for storage or recovery. That is, the control device 400 is further configured to: after controlling the transmission device 300 to transmit the standard sample container output from the re-dissolving device 200 and loaded with the liquid standard sample 50 to the sample measuring device 100, control the sample measuring device 100 to absorb at least part of the liquid standard sample 50 from the standard sample container and distribute it to the first reaction container, and control the transmission device 300 to transmit the standard sample container after the sample measuring device 100 absorbs the liquid standard sample 50 from the sample measuring device 100 to the re-dissolving device 200 for storage or recovery. In this embodiment, the standard sample container loaded with the liquid standard sample 50 is returned to the re-dissolving device 200 for storage and recovery after the sample measuring device 100 completes the sample aspiration of the standard sample measurement item, which is conducive to the unified management of the standard sample and its loading container. Of course, in specific applications, as an alternative embodiment, the standard sample container loaded with the liquid standard sample 50 can be stored and / or recovered in the sample measuring device 100 after the sample measuring device 100 completes the aspiration of the standard sample measurement item, or can be transferred to other areas or devices other than the reconstitution device 200 and the sample measuring device 100 for storage and / or recovery.

[0230] As an embodiment, the above-mentioned control transmission device 300 transfers the first container 20 output from the re-dissolution device 200 and loaded with the liquid standard sample 50 to the sample measuring device 100, including: when the first preset condition is met, the control transmission device 300 transfers the first container 20 output from the re-dissolution device 200 and loaded with the liquid standard sample 50 to the sample measuring device 100.

[0231] The above-mentioned control of the sample measuring device 100 to absorb at least a portion of the liquid standard sample 50 loaded in the first container 20 and distribute it to the first reaction container includes: controlling the sample measuring device 100 to absorb at least a portion of the liquid standard sample 50 loaded in the first container 20 and distribute it to the first reaction container; controlling the transmission device 300 to transmit the first container 20 output from the sample measuring device 100 and after the sample measuring device 100 absorbs and distributes at least a portion of the liquid standard sample 50 to the re-dissolution device 200 for storage or recovery.

[0232] As an embodiment, the control device 400 is further configured to: after controlling the transmission device 300 to transfer the first container 20 output from the sample measuring device 100 and after the sample measuring device 100 absorbs and dispenses at least a portion of the liquid standard sample 50 to the re-dissolution device 200 for storage, when the first preset condition is met again, determine whether the first container 20 output from the sample measuring device 100 and after the sample measuring device 100 absorbs and dispenses at least a portion of the liquid standard sample 50 meets the second preset condition; if so, control the re-dissolution device 200 to output the first container 20 that meets the second preset condition to the transmission device 300, and control the transmission device 300 to transfer the first container 20 output from the re-dissolution device 200 and that meets the second preset condition to the sample measuring device 100. In this embodiment, when the first preset condition is met and the standard sample measurement project needs to be executed, first check whether the liquid standard sample 50 in the reconstitution device 200 meets the second preset condition. If the second preset condition is met, the liquid standard sample 50 is preferentially called out and transmitted to the sample measurement device 100 for measurement to avoid waste of the liquid standard sample 50; if the second preset condition is met, the freeze-dried standard sample 40 needs to be re-dissolved.

[0233] As an embodiment, the second preset condition is that the amount of the liquid standard sample 50 loaded in the first container 20 is greater than or equal to the amount of liquid standard sample 50 required for a standard sample measurement project (a quality control project or a calibration project). In this embodiment, when the first preset condition is met and the standard sample measurement project needs to be performed, first check whether the remaining amount of the liquid standard sample 50 in the reconstitution device 200 is sufficient. If the remaining amount is sufficient, the liquid standard sample 50 is preferentially transferred to the sample measurement device 100 for measurement to avoid waste of the liquid standard sample 50; if the remaining amount is insufficient, the freeze-dried standard sample 40 needs to be reconstituted.

[0234] As an alternative implementation of the second preset condition, the second preset condition is: the liquid volume of the liquid standard sample 50 loaded in the first container 20 is greater than or equal to the demand for the liquid standard sample 50 for a standard sample measurement project (a quality control project or a calibration project), and the liquid standard sample 50 in the first container 20 is within the validity period. In this embodiment, in addition to sufficient residual volume, the second preset condition also needs to meet the requirement of being within the validity period. In this way, in a specific application, when the first preset condition is met and the standard sample measurement project needs to be performed, first check whether the liquid standard sample 50 reconstituted in the reconstitution device 200 and packaged in the first container 20 is within the validity period and whether the residual volume is sufficient. If it is within the validity period and the residual volume is sufficient, the liquid standard sample 50 in the first container 20 is preferentially transferred to the sample measurement device 100 for measurement; if it exceeds the validity period or the residual volume is insufficient, the freeze-dried standard sample 40 needs to be reconstituted.

[0235] As an embodiment, the above-mentioned control of the reconstitution device 200 to reconstitute the freeze-dried standard sample 40 in the first container 20 into a liquid standard sample 50 includes: controlling the reconstitution solution dispensing mechanism 210 to dispense the reconstitution solution into the freeze-dried standard sample 40 in the first container 20, so that the freeze-dried standard sample 40 and the reconstitution solution are mixed to form the liquid standard sample 50. The above-mentioned control of the transmission device 300 to transmit the first container 20 output from the sample measuring device 100 and after the sample measuring device 100 absorbs and distributes at least a part of the liquid standard sample 50 to the reconstitution device 200 for storage or recovery includes: controlling the transmission device 300 to transmit the first container 20 output from the sample measuring device 100 and after the sample measuring device 100 absorbs and distributes at least a part of the liquid standard sample 50 to the storage mechanism 230 (refrigeration mechanism 231 or freezing mechanism 232) for storage. The control device 400 is further configured to control the second transfer mechanism 250 to transfer the first container 20 that meets the second preset condition from the storage mechanism 230 (refrigeration mechanism 231 or freezing mechanism 232) to the rewarming mechanism 240 for temperature increase treatment before controlling the re-dissolving device 200 to output the first container 20 that meets the second preset condition to the transmission device 300. In this embodiment, after the liquid standard sample 50 is stored in the refrigeration mechanism 231 or the freezing mechanism 232, before it is needed, it is first heated by the rewarming mechanism 240 to restore the temperature of the liquid standard sample 50 to the preset range, thereby preventing the temperature of the liquid standard sample 50 from affecting the efficiency and results of the standard sample determination.

[0236] Reference Figure 1 , Figure 2 and Figure 3 As shown, as an embodiment, the sample measuring device 100 includes a sample measuring mechanism 140, and the pipetting mechanism is used to aspirate at least a portion of the liquid standard sample 50 loaded in the standard sample container located at the first sample aspiration position and distribute it into the first reaction container; the sample measuring mechanism 140 is used to measure the first reaction liquid in the first reaction container made of at least the liquid standard sample 50 distributed into the first reaction container.

[0237] Reference Figure 1 and Figures 3 to 8 As shown, as an embodiment, the sample measuring device 100 also includes a sample storage mechanism 110, a sample scheduling mechanism 120 and a sample dispensing mechanism 130. The sample storage mechanism 110 is at least used to store the sample to be tested; the sample scheduling mechanism 120 is used to schedule the sample to be tested from the sample storage mechanism 110 to a second sample suction position; the sample dispensing mechanism 130 is used to absorb the sample to be tested from the second sample suction position and distribute it to a second reaction container; the sample measuring mechanism 140 is used to measure the second reaction liquid made of at least the sample to be tested in the second reaction container.

[0238] As an embodiment, the control of the transmission device 300 to transmit the standard sample container output from the re-dissolving device 200 and loaded with at least a portion of the liquid standard sample 50 to the sample measuring device 100 includes: controlling the transmission device 300 to transmit the standard sample container output from the re-dissolving device 200 and loaded with at least a portion of the liquid standard sample 50 to the sample storage mechanism 110. The sample storage mechanism 110 is used to store sample containers loaded with samples to be tested, and to store standard sample containers transferred by the transmission device 300 and loaded with at least a portion of the liquid standard sample 50. The sample scheduling mechanism 120 is used to schedule the standard sample container loaded with at least a portion of the liquid standard sample 50 from the sample storage mechanism 110 to the first sample suction position, and to schedule the sample container loaded with the sample to be tested from the sample storage mechanism 110 to the second sample suction position. The sample distribution mechanism 130 is used to absorb at least a portion of the sample to be tested loaded in the sample container located at the second sample suction position and distribute it to the second reaction container. The sample measuring mechanism 140 is used to measure the first reaction liquid made of at least the liquid standard sample 50 allocated to the first reaction container in the first reaction container, and to measure the second reaction liquid made of at least the sample to be tested allocated to the second reaction container in the second reaction container. In this embodiment, the transmission device 300 is used to transmit the standard sample container output from the re-dissolution device 200 and loaded with at least part of the liquid standard sample 50 to the sample storage mechanism 110. The sample storage mechanism 110 is at least used to realize the loading of the sample to be tested and to store the liquid standard sample 50. In specific applications, the sample container loaded with the sample to be tested can be placed in the loading area 111 of the sample storage mechanism 110 by an operator or an operating robot to realize the loading of the sample to be tested. The sample scheduling mechanism 120 can schedule the sample container placed in the sample storage mechanism 110 to the second sample suction position for the sample distribution mechanism 130 to suck the sample. In this embodiment, the sample to be tested and the liquid standard sample 50 are waiting for loading (waiting to be sent to the sample suction position) in the same sample storage mechanism 110 and are dispatched to the sample suction position through the same sample dispatching mechanism 120, which helps to simplify the structure of the sample analysis device 10.

[0239] As an implementation manner, the first sample suction position and the second sample suction position are located at the same position or at two different positions.

[0240] As an embodiment, the first reaction container and the second reaction container are two reaction containers of the same shape and size. That is, the first reaction container and the second reaction container are two reaction containers of the same specifications. Of course, in a specific application, the first reaction container and the second reaction container may also be two reaction containers of different shapes and / or sizes.

[0241] Reference Figures 3 to 8As shown, as an embodiment, the sample measuring device 100 further includes a reaction container supply mechanism 170, the reaction container supply mechanism 170 has a container output channel of one number, the container output channel is used to output the first reaction container and the second reaction container; the liquid transfer mechanism is used to draw at least part of the liquid standard sample 50 loaded therein from the standard sample container and distribute it to the first reaction container outputted by the container output channel; the sample distribution mechanism 130 is used to draw at least part of the sample to be tested loaded therein from the sample container and distribute it to the second reaction container outputted by the container output channel. In this embodiment, the standard sample measurement and the sample to be tested measurement share the same reaction container supply mechanism 170 to supply the reaction container, which is conducive to simplifying the structure of the sample measuring device 100. Of course, in specific applications, the standard sample measurement and the sample to be tested measurement use different reaction container supply mechanisms 170 to supply the reaction container, for example, as an alternative embodiment, the sample measuring device 100 includes two reaction container supply mechanisms 170, one reaction container supply mechanism 170 is used to output the first reaction container, and the other reaction container supply mechanism 170 is used to output the second reaction container.

[0242] Reference Figure 1 and Figures 3 to 8 As shown, as an embodiment, the sample measuring device 100 further includes a reaction container transport mechanism 180, which is used to transfer the reaction container. The reaction container is a disposable container, that is, after the reaction container carries the sample to be measured and completes the measurement of the corresponding measurement item, it is discarded and recycled without being cleaned and reused in the sample analysis device 10, thereby simplifying the structure and working procedures of the sample analysis device 10. Of course, in specific applications, the reaction container can also be recycled after cleaning.

[0243] Reference Figures 3 to 8 As shown, as an embodiment, the sample measuring device 100 further includes a reagent dispensing mechanism 150, which is used to draw reagents from the reagent container and dispense them into the first reaction container, and to draw reagents from the reagent container and dispense them into the second reaction container.

[0244] As an embodiment, the pipetting mechanism and the sample dispensing mechanism 130 are the same mechanism, that is, the sample dispensing mechanism 130 is reused to distribute the sample to be tested and the liquid standard sample 50. In this embodiment, the pipetting mechanism and the sample dispensing mechanism 130 are the same mechanism, and the reagent dispensing mechanism 150 and the sample dispensing mechanism 130 are two independent mechanisms. Of course, in a specific application, as an alternative embodiment, the pipetting mechanism, the reagent dispensing mechanism 150 and the sample dispensing mechanism 130 can also be the same mechanism; or, the pipetting mechanism, the reagent dispensing mechanism 150 and the sample dispensing mechanism 130 can also be three independent mechanisms; or, the pipetting mechanism and the reagent dispensing mechanism 150 can be the same mechanism, and the pipetting mechanism and the sample dispensing mechanism 130 can be two independent mechanisms, that is, in a specific application: the pipetting mechanism and the sample dispensing mechanism 130 can be the same mechanism or two independent mechanisms, and the pipetting mechanism and the reagent dispensing mechanism 150 can be the same mechanism or two independent mechanisms.

[0245] In the above scheme, the standard sample container output from the reconstitution device 200 and loaded with at least a portion of the liquid standard sample 50 is transferred to the sample storage mechanism 110 for storage. Of course, in specific applications, the standard sample container output from the reconstitution device 200 and loaded with at least a portion of the liquid standard sample 50 is not necessarily transferred to the sample storage mechanism 110 for storage. For example, as an alternative embodiment, the sample measurement device 100 includes a sample storage mechanism 110, a sample scheduling mechanism 120, a sample dispensing mechanism 130, a reagent dispensing mechanism 150, a liquid transfer mechanism and a sample measurement mechanism 140; the sample storage mechanism 110 is used to store sample containers loaded with samples to be tested; the sample scheduling mechanism 120 is used to dispatch the sample containers loaded with samples to be tested from the sample storage mechanism 110 to the second sample suction position; the sample dispensing mechanism 130 is used to absorb at least a portion of the sample to be tested loaded in the sample container located at the second sample suction position and distribute it to the second reaction container. The above-mentioned control of the transmission device 300 to transmit the standard sample container output from the re-dissolving device 200 and loaded with at least a portion of the liquid standard sample 50 to the sample measuring device 100 includes: controlling the transmission device 300 to transmit the standard sample container output from the re-dissolving device 200 and loaded with at least a portion of the liquid standard sample 50 to the third sample suction position, and the third sample suction position and the second sample suction position are located at the same position or at two different positions. The above-mentioned control of the sample measuring device 100 to absorb at least a portion of the liquid standard sample 50 loaded therein from the standard sample container and distribute it to the first reaction container includes: controlling the pipetting mechanism to absorb at least a portion of the liquid standard sample 50 loaded therein from the standard sample container located at the third sample suction position and distribute it to the first reaction container. The reagent dispensing mechanism 150 is used to absorb the reagent from the reagent container and distribute it to the first reaction container, and is used to absorb the reagent from the reagent container and distribute it to the second reaction container. The sample measuring mechanism 140 is used to measure the first reaction liquid in the first reaction container, which is made of at least the liquid standard sample 50 and the reagent distributed in the first reaction container, and to measure the second reaction liquid in the second reaction container, which is made of at least the sample to be tested distributed in the second reaction container and the reagent. The pipetting mechanism and the reagent dispensing mechanism 150 are the same mechanism or two independent mechanisms. In this alternative embodiment, the distribution of the liquid standard sample 50 can share a pipetting needle with the distribution of the reagent, and the standard sample container output from the re-dissolving device 200 and loaded with at least part of the liquid standard sample 50 is transferred to the reagent area for storage; or the distribution of the liquid standard sample 50 can also share neither a pipetting needle with the distribution of the sample to be tested nor a pipetting needle with the distribution of the reagent.

[0246] As an embodiment, the sample storage mechanism 110 is also used to unload the sample to be tested. The sample container after the sample suction is completed can be dispatched by the sample dispatching mechanism 120 to the unloading area 112 of the sample storage mechanism 110, so that the operator or the operating robot can take it away for recycling, or the transmission device 300 can be transported to other areas (such as the sample management device 700 described below) for recycling. The loading area 111 and the unloading area 112 can be set separately and independently of each other, or they can be set as an integrated whole.

[0247] As an implementation mode, the sample container is loaded, dispatched and recovered through the second sample rack, that is, the operator or the operating robot places the second sample rack loaded with at least one sample container in the loading area 111 of the sample storage mechanism 110, and then the sample dispatching mechanism 120 dispatches the second sample rack placed in the loading area 111 to the sample suction position for sample suction, and then the sample dispatching mechanism 120 dispatches the second sample rack after sample suction to the unloading area 112. The use of the second sample rack to carry the sample container for loading, dispatching and recovery is conducive to making the sample analysis device 10 suitable for sample containers of different specifications on the one hand, and is conducive to batch loading and recovery of samples on the other hand; it is also conducive to the operator not having to touch the sample container, which is conducive to avoiding the risk of infection. Of course, in specific applications, as an alternative implementation scheme, the sample container can also be loaded, dispatched and recovered through the sample seat.

[0248] As an embodiment, the sample storage mechanism 110 is also used to implement the caching of sample containers. The sample storage mechanism 110 also includes a buffer area 113. The sample scheduling mechanism 120 is also used to: schedule the second sample rack loaded with the sample to be tested to the buffer area 113 to queue for sample suction, schedule the second sample rack loaded with the sample to be tested from the buffer area 113 to the second sample suction position for sample suction, schedule the second sample rack loaded with the sample that needs to be retested to the buffer area 113 to wait for re-sampling and detection, and schedule the second sample rack loaded with the sample that needs to be retested to the sample suction position for sample suction. The buffer area 113 can be independently set up separately from the loading area 111 and the unloading area 112, or it can be integrated with the loading area 111 and / or the unloading area 112.

[0249] As an embodiment, the above-mentioned control transmission device 300 transfers the standard sample container output from the re-dissolving device 200 and loaded with at least a part of the liquid standard sample 50 to the sample storage mechanism 110, including: controlling the transmission device 300 to transfer the first sample rack 30 output from the re-dissolving device 200 and loaded with the standard sample container to the sample storage mechanism 110. The sample storage mechanism 110 is used to store the first sample rack 30 from the transmission device 300 and loaded with the standard sample container, and the second sample rack loaded with the sample container and the sample container loaded with the sample to be tested. The sample scheduling mechanism 120 is used to schedule the first sample rack 30, so that the first sample rack 30 from the sample storage mechanism 110 drives the standard sample container loaded with at least a part of the liquid standard sample 50 to be scheduled to the first sample suction position, and is used to schedule the second sample rack, so that the second sample rack from the sample storage mechanism 110 drives the sample container loaded with the sample to be tested to be scheduled to the second sample suction position. The first sample rack 30 has at least two first placement positions, each of which is used to place a single standard sample container, and the second sample rack has at least two second placement positions, each of which is used to place a single sample container. The first sample rack 30 is used to carry the standard sample container for transmission and scheduling. On the one hand, it is beneficial for the sample analysis device 10 to be applicable to standard sample containers of different specifications. On the other hand, it is beneficial for the operator not to touch the standard sample container, which is beneficial to avoid the risk of infection. On the other hand, it is beneficial for the storage and scheduling of the standard sample container in the sample measurement device 100 to be similar to that of the sample container.

[0250] As an embodiment, the first sample rack 30 and the second sample rack are two sample racks of the same specifications, that is, the first sample rack 30 and the second sample rack are two sample racks of the same shape and size. The sample scheduling mechanism 120 is used to schedule a sample rack loaded with at least one sample container and a sample to be tested in the sample container to the sample suction position of the sample distribution mechanism 130, and is used to schedule a sample rack loaded with at least one first container 20 and a liquid standard sample 50 in the first container 20 to the sample suction position of the sample distribution mechanism 130. In this embodiment, the liquid standard sample 50 and the sample to be tested are scheduled to the sample suction position using the same sample rack and the same sample scheduling mechanism 120, which is conducive to simplifying the structure of the sample analysis device 10. Of course, in a specific application, as an alternative embodiment, the first sample rack 30 and the second sample rack can also be two sample racks of different shapes and / or sizes.

[0251] Reference Figures 3 to 8As shown, as an embodiment, the transmission device 300 includes a transmission track 310 and a first transfer mechanism (not shown), and the transmission track 310 is provided with a sample injection position 311; the above-mentioned control of the transmission device 300 to transfer the standard sample container output from the reconstitution device 200 and loaded with at least part of the liquid standard sample 50 to the sample measurement device 100 includes: controlling the transmission track 310 to transfer the standard sample container output from the reconstitution device 200 and loaded with at least part of the liquid standard sample 50 to the sample injection position 311; controlling the first transfer mechanism to transfer the standard sample container loaded with at least part of the liquid standard sample 50 from the sample injection position 311 to the sample measurement device 100. The transmission track 310 is mainly used to carry the standard sample container output from the reconstitution device 200 to the sample injection position 311, and the first transfer mechanism is mainly used to transfer the standard sample container at the sample injection position 311 to the sample measurement device 100. Of course, in specific applications, the first transfer mechanism may not be provided, and the standard sample container may be directly transported to the sample measurement device 100 by the transmission track 310.

[0252] As an embodiment, the control of the transmission track 310 to transfer the standard sample container output from the reconstitution device 200 and loaded with at least part of the liquid standard sample 50 to the sample injection position 311 includes: controlling the transmission track 310 to transfer the first sample rack 30 output from the reconstitution device 200 and loaded with the standard sample container to the sample injection position 311. The control of the first transfer mechanism to transfer the standard sample container loaded with at least part of the liquid standard sample 50 from the sample injection position 311 to the sample measurement device 100 includes: controlling the first transfer mechanism to transfer the first sample rack 30 loaded with the standard sample container and the standard sample container loaded with at least part of the liquid standard sample 50 from the sample injection position 311 to the sample measurement device 100. In this embodiment, the transmission track 310 uses the first sample rack 30 as a carrier to transfer the standard sample container, and the first transfer mechanism uses the first sample rack 30 as a carrier to transfer the standard sample container. Of course, in a specific application, as an alternative embodiment, the transmission device 300 can also use the sample seat as a carrier to transmit and / or transfer the standard sample container. The sample holder has only one first placement position and can only transfer one standard sample container at a time.

[0253] As an embodiment, the first transfer mechanism is a pusher mechanism for pushing the first sample rack 30 from the sample loading position 311 to the sample measuring device 100. Of course, in specific applications, the first transfer mechanism is not limited thereto, and can also be transferred by a robot or by a track.

[0254] As an implementation mode, the reconstitution device 200 and the transfer track 310 are respectively distributed on two adjacent sides of the sample measurement device 100 , so that it is convenient for the transfer track 310 to transfer the standard sample container.

[0255] Reference Figure 3 , Figure 4 and Figure 8 As shown, as an embodiment, the sample measuring device 100 includes a sample storage mechanism 110, and the sample storage mechanism 110 includes a loading area 111 and an unloading area 112. The loading area 111 and the unloading area 112 are arranged at intervals along the transmission track 310, and the loading area 111 and the unloading area 112 are respectively arranged near the two ends of the transmission track 310, and the re-dissolving device 200 is arranged near the unloading area 112 or the loading area 111; the sample input position 311 is located at a position opposite to the loading area 111 of the transmission track 310; an inlet and outlet 312 is formed at one end of the transmission track 310 away from the re-dissolving device 200, and the inlet and outlet 312 is at least used for the input of a second sample rack loaded with a sample container and the sample container loaded with a sample to be tested. The transmission track 310 is used to: along the first direction X 1 The second sample rack loaded with sample containers from the entrance 312 is transferred to the sample loading position 311. The transfer track 310 is also used to: 2 The first sample rack 30 loaded with the standard sample container output from the reconstitution device 200 is transferred to the sample injection position 311 toward the inlet and outlet 312. The first transfer mechanism is used to transfer the first sample rack 30 located at the sample injection position 311 to the loading area 111, and to transfer the second sample rack located at the sample injection position 311 to the loading area 111. 1 With the second direction X 2 In this embodiment, the loading area 111 and the unloading area 112 are separately arranged, and the reconstitution device 200 is arranged near the unloading area 112 or the loading area 111, and the multiplexing transmission track 310 transmits the second sample rack loaded with sample containers to the sample injection position 311 and the first sample rack 30 loaded with standard sample containers to the sample injection position 311, so that it is beneficial to use the existing track of the sample analysis device 10 as the transmission track 310, thereby helping to simplify the improvement cost of the sample analysis device 10.

[0256] Of course, in a specific application, the configuration of the loading area 111 and the unloading area 112 is not limited to the above-mentioned configuration of being separately disposed at both ends of the transmission track 310. Figure 5 , Figure 6 and Figure 8As shown, as an alternative embodiment, the loading area 111 and the unloading area 112 are adjacent to or integrated with each other and are arranged near the same end of the transfer track 310; the sample introduction position 311 is located at a position of the transfer track 310 that is directly opposite to the loading area 111; the reconstitution device 200 is arranged near one end of the transfer track 310, and the end of the transfer track 310 away from the reconstitution device 200 is formed with an inlet and outlet 312, and the inlet and outlet 312 is at least used for inputting a second sample rack loaded with a sample container and a sample to be tested in the sample container; the transfer track 310 The first transfer mechanism is used to: transfer the second sample rack loaded with sample containers from the entrance 312 to the sample injection position 311 along the first direction X1; the transfer track 310 is also used to: transfer the first sample rack 30 loaded with standard sample containers output from the reconstitution device 200 to the sample injection position 311 toward the entrance 312 along the second direction X2; the first transfer mechanism is used to transfer the first sample rack 30 located at the sample injection position 311 to the loading area 111, and to transfer the second sample rack located at the sample injection position 311 to the loading area 111; wherein, the first direction X2 is 1 With the second direction X 2 In this alternative embodiment, the reconstitution device 200 and the loading area 111 and the unloading area 112 can be close to the same end of the transfer track 310, or the reconstitution device 200 can be close to one end of the transfer track 310, and the loading area 111 and the unloading area 112 can be close to the other end of the transfer track 310.

[0257] Reference Figures 3 to 8 As shown, as an embodiment, the transport track 310 is also used to transport the vehicle along the second direction X. 2 The sample rack output from the unloading area 112 is transferred toward the entrance 312. The sample analysis device 10 further includes a first information acquisition component 600, which is disposed beside the transfer track 310 or on the transfer track 310, and is used to acquire information of the sample rack output from the unloading area 112 and transferred toward the entrance 312 by the transfer track 310, or to acquire information of containers loaded on the sample rack output from the unloading area 112 and transferred toward the entrance 312 by the transfer track 310. The control device 400 is further configured to: determine the type of liquid loaded in the container on the sample rack output from the unloading area 112 and transported by the transport track 310 toward the entrance 312, or determine the type of the container on the sample rack output from the unloading area 112 and transported by the transport track 310 toward the entrance 312, according to the information of the sample rack or the information of the container fed back by the first information acquisition component 600; if it is determined that the type of the liquid loaded in the container on the sample rack is the sample to be tested or the type of the container loaded on the sample rack is the sample container, control the transport track 310 to move along the second direction X 2The sample rack is transferred to the entrance 312 for recycling; if the type of liquid loaded in the container on the sample rack is determined to be a liquid standard sample 50 or the type of container loaded on the sample rack is determined to be a standard sample container, the transfer track 310 is controlled to move along the first direction X 1 The sample rack is transferred to the reconstitution device 200 for storage or recycling. In this embodiment, the type of container on the sample rack output from the unloading area 112 and transferred by the transfer track 310 toward the entrance 312 is determined according to the feedback information of the first information acquisition component 600, and then the transfer direction of the transfer track 310 is controlled to transfer the standard sample container and the sample container output from the unloading area 112 to different areas for storage or recycling, so as to facilitate the management and reuse of the standard sample container. Of course, in a specific application, as an alternative embodiment, the standard sample container and the sample container output from the unloading area 112 can also be transferred to the same area for storage or recycling.

[0258] As an implementation manner, the first information acquisition component 600 includes at least one of a visual camera, a barcode scanner, a two-dimensional code scanner, and a wireless radio frequency code reader.

[0259] Reference Figures 3 to 8 As shown, as an embodiment, the sample storage mechanism 110 also includes a buffer area 113. The control device 400 is further configured to: control the sample scheduling mechanism 120 to schedule the first sample rack 30 loaded with the standard sample container and after the standard sample container is sucked and dispensed with the liquid standard sample 50 by the pipetting mechanism, from the first sample suction position to the buffer area 113 for caching; if information is obtained that at least one of the liquid standard samples 50 in the standard sample container in the first sample rack 30 cached in the buffer area 113 needs to be retested, then control the sample scheduling mechanism 120 to dispatch the first sample rack 30 loaded with the standard sample container that needs to be retested from the buffer area 113 The sample rack 30 is dispatched to the first sample suction position, and the pipetting mechanism is controlled to re-absorb and distribute at least part of the liquid standard sample 50 loaded in the standard sample container that needs to be re-measured and is located at the first sample suction position; if the information that the liquid standard samples 50 in all the standard sample containers in the first sample rack 30 cached in the buffer area 113 do not need to be re-measured is obtained, the sample scheduling mechanism 120 is controlled to dispatch the first sample rack 30 from the buffer area 113 to the unloading area 112; wherein the pipetting mechanism and the sample distribution mechanism 130 are the same mechanism or two independent mechanisms. In this embodiment, by setting the buffer area 113, after the first sample rack 30 loaded with the liquid standard sample 50 is aspirated and distributed, it can be cached in the buffer area 113 to wait for the re-measurement instruction, so that the standard sample container that needs to be re-measured can be quickly transported to the first sample suction position, thereby improving the efficiency of the standard sample re-measurement.

[0260] As an embodiment, the control device 400 is further configured to: control the sample scheduling mechanism 120 to schedule the second sample rack loaded with sample containers and after the sample containers are sucked and distributed with the samples to be tested by the sample distribution mechanism 130, from the second sample suction position to the buffer area 113 for caching; if information is obtained that the samples to be tested in at least one sample container in the second sample rack cached in the buffer area 113 need to be retested, then control the sample scheduling mechanism 120 to schedule the second sample rack loaded with sample containers that need to be retested from the buffer area 113 to the second sample suction position, and control the sample distribution mechanism 130 to re-absorb and distribute at least part of the samples to be tested loaded therein from the sample containers that need to be retested located in the second sample suction position; if information is obtained that the samples to be tested in all the sample containers in the second sample rack cached in the buffer area 113 do not need to be retested, then control the sample scheduling mechanism 120 to schedule the second sample rack from the buffer area 113 to the unloading area 112. In this embodiment, the second sample rack loaded with the samples to be tested can also be cached in the buffer area 113 after the samples are sucked to wait for the retest instruction.

[0261] Reference Figure 1 and Figure 7 As shown, as an embodiment, the sample analysis device 10 further includes a sample management device 700, and the sample management device 700 and the re-dissolving device 200 are respectively located on opposite sides of the sample measurement device 100, such as the left and right sides. One end of the transmission track 310 extends to the sample management device 700, and the other end extends to the re-dissolving device 200. The entrance and exit 312 is located at one end of the transmission track 310 close to the sample management device 700. The sample management device 700 is used for placing sample containers loaded with samples to be tested to achieve the loading of samples to be tested and for storing sample containers after the determination is completed to wait for recycling. The second sample rack loaded with the samples to be tested is transported from the sample management device 700 to the transmission track 310 through the entrance and exit 312, and the second sample rack output from the unloading area 112 is transported to the sample management device 700 through the entrance and exit 312.

[0262] As an embodiment, the sample dispensing mechanism 130 includes a first sample needle, a first suction and discharge driving component, and a first motion driving component; the first sample needle is used to absorb and discharge the liquid standard sample 50. The first suction and discharge driving component is used to provide driving force for the first sample needle to absorb and discharge the sample. The first motion driving component is used to drive the first sample needle to move in two-dimensional or three-dimensional space, so that the first sample needle moves to different positions, such as the standby position, the sample suction position, the sample addition position, the cleaning position, etc.

[0263] As an embodiment, the first suction and discharge driving component is a syringe. Of course, in specific applications, the configuration of the first suction and discharge driving component is not limited thereto, and may also be a pump or a positive and negative pressure driving structure, for example.

[0264] As an embodiment, the sample distribution mechanism 130 is the same mechanism as the pipetting mechanism, that is, the first pipetting needle is the first sample needle, and the pipetting mechanism includes the first sample needle, the first suction and discharge driving component, and the first motion driving component. The first container 20 has a bottle stopper 2201 and / or a bottle cap 2202, and the first sample needle has a puncture function, that is, the first sample needle is a puncture needle. The first sample needle is at least used to puncture the bottle stopper 2201 and / or the bottle cap 2202 of the first container 20 to at least partially penetrate into the first container 20 and absorb the liquid standard sample 50. The first sample needle can directly puncture the sealing member 22 of the bottle mouth of the first container 20 to absorb the sample, without the need to set the plugging mechanism 190 and the cover removal mechanism 101, which is conducive to simplifying the structure of the sample analysis device 10, and because the time for removing the plug and / or the cover is saved, it is conducive to improving the measurement efficiency. In this embodiment, the reconstituted liquid standard sample 50 can be directly measured on the machine without the need for secondary packaging into other containers, and there is no need to remove the bottle stopper 2201 and / or bottle cap 2202 of the container containing the standard sample, which makes the measurement of the standard sample more convenient and helps to reduce the contact between the liquid standard sample 50 and the air, making the performance of the liquid standard sample 50 more stable.

[0265] As an implementation method, the first sample needle adopts a one-absorption-one-test scheme, that is, the first sample needle absorbs the standard sample amount or the sample amount to be tested corresponding to the project each time it aspirates. Of course, in specific applications, as an alternative implementation method, the first sample needle can also adopt a one-absorption-multiple-test scheme, that is, if it is a single-project standard sample or a single-project sample to be tested, the sample amount or the sample amount to be tested corresponding to the project is aspirated at one time; if it is a multi-project composite standard sample or a multi-project sample to be tested, the sum of the standard sample amounts corresponding to all standard sample projects or the sum of the sample amounts corresponding to all sample measurement projects is aspirated at one time.

[0266] Reference Figures 3 to 8 As shown, as an embodiment, the sample measuring mechanism 140 includes an incubation part 141 and a measuring part 142, the incubation part 141 is used to incubate a first liquid containing at least a sample to be tested in a second reaction container to produce a second liquid and to incubate a third liquid containing at least a liquid standard sample 50 in a first reaction container to produce a fourth liquid, and the measuring part 142 is used to measure a second reaction liquid made of at least the second liquid and a reagent in the second reaction container and to measure a first reaction liquid made of at least the fourth liquid and a reagent in the first reaction container.

[0267] As an embodiment, the measuring component 142 includes at least one illumination component and a plurality of light receiving components, wherein the illumination component is used to emit light toward a first reaction container loaded with a first reaction liquid, and is used to emit light toward a second reaction container loaded with a second reaction liquid. The plurality of first light receiving components are respectively used to receive light information generated after the light is transmitted, reflected or scattered by the first reaction liquid or the second reaction liquid. The light receiving component may be a photodetector PD, which may realize photoelectric conversion.

[0268] As an embodiment, the measuring component 142 also includes a measuring bearing component, which is formed with a plurality of detection holes, each of which can accommodate a reaction container for measurement. The illumination component uses light to illuminate the reaction container loaded with the first reaction liquid or the second reaction liquid in the detection hole, and the light is received by the light receiving component, and the sample to be tested or the liquid standard sample 50 is analyzed by analyzing the received light intensity signal. In this embodiment, the measuring bearing component and the incubation component 141 are arranged independently of each other; of course, in a specific application, as an alternative embodiment, the measuring bearing component and the incubation component 141 can also be integrated into one.

[0269] Reference Figures 3 to 8 As shown, as an embodiment, the sample measuring device 100 further includes a reagent tray 160 and a reagent dispensing mechanism 150. The reagent tray 160 is used to carry reagent containers, and the reagent containers are loaded with reagents for measuring sample measuring items or standard sample measuring items. The reagent dispensing mechanism 150 is used to absorb reagents from the reagent containers in the reagent tray 160 and dispense the absorbed reagents into the reaction containers.

[0270] As an embodiment, the sample detection data includes the coagulation item detection data of the sample to be tested. The sample determination device 100 is a coagulation determination device, which is used to perform coagulation related parameter determination on the sample to be tested. The sample determination device 100 adopts at least one method of coagulation method, immunoturbidimetry and chromogenic substrate method to determine the coagulation determination item of the first reaction liquid made of at least the sample to be tested and the reagent. The main process of the coagulation determination item includes: adding the sample to be tested and the reagent (possibly one or more reagents) to the reaction container, and mixing and incubating the mixed solution of the added sample to be tested and the reagent to prepare a second reaction liquid, and then using the light emitted by the illumination component to irradiate the second reaction container loaded with the second reaction liquid, and the light receiving component (such as the detector PD) receives it, and analyzes the received optical signal (such as light intensity) to complete the analysis of the second reaction liquid. Of course, in specific applications, the sample determination device 100 is not limited to a coagulation determination device, for example, it can also be a biochemical determination device or an immunoassay device or a blood cell determination device.

[0271] Reference Figures 3 to 8As shown, as an embodiment, the reagent dispensing mechanism 150 includes a mixed reagent dispensing mechanism 151 and a trigger reagent dispensing mechanism 152, the mixed reagent dispensing mechanism 151 is used to draw the mixed reagent from the mixed reagent container and distribute it to the reaction container, and the trigger reagent dispensing mechanism 152 is used to draw the trigger reagent from the trigger reagent container and distribute it to the reaction container. The mixed reagent dispensing mechanism 151 and the trigger reagent dispensing mechanism 152 are independently arranged, and the mixed reagent dispensing mechanism 151 and the trigger reagent dispensing mechanism 152 can work in parallel, so that the mixed reagent dispensing operation of one reaction container can be performed simultaneously with the trigger reagent dispensing operation of another reaction container at the same time. Of course, in specific applications, as an alternative implementation scheme, the dispensing operation of the mixed reagent and the dispensing operation of the trigger reagent can also be performed by the same reagent dispensing mechanism.

[0272] As an embodiment, the mixed reagent dispensing mechanism 151 includes a mixed reagent needle, a second suction and discharge driving component for driving the mixed reagent needle to suck and discharge the mixed reagent, and a second motion driving component for driving the mixed reagent needle to move in space. The trigger reagent dispensing mechanism 152 includes a trigger reagent needle, a third suction and discharge driving component for driving the trigger reagent needle to suck and discharge the trigger reagent, and a third motion driving component for driving the trigger reagent needle to move in space.

[0273] As an embodiment, each coagulation measurement item includes at least a sample addition period, an incubation period, a trigger reagent period, and a measurement period, which are performed in sequence. In the sample addition period, the control device 400 controls the sample addition operation. In the incubation period, the control device 400 controls the incubation operation. In the trigger reagent period, the control device 400 controls the trigger reagent addition operation. In the measurement period, the control device 400 controls the measurement operation.

[0274] As an embodiment, each coagulation test item further includes a cup throwing period after the test period, that is, each coagulation test item includes a sample addition period, an incubation period, a trigger reagent period, a test period, and a cup throwing period in sequence. During the cup throwing period, the control device 400 controls the reaction container that has completed the test to be thrown out.

[0275] As an embodiment, the coagulation measurement items that can be completed by the sample measurement device 100 include but are not limited to: plasma prothrombin item (PT), activated partial thromboplastin item (APTT), fibrinogen item (FIB), thrombin item (TT) and antithrombin III item (ATIII), etc. Among them, the activated partial thromboplastin item (APTT) is a multi-reagent measurement item, and mixed reagents need to be added during the incubation process to prepare the reaction solution.

[0276] As an embodiment, the sample analysis device 10 includes a single sample determination device 100, that is, the sample analysis device 10 is a single sample analyzer. Of course, in a specific application, as an alternative embodiment, the sample analysis device 10 may also include more than two sample determination devices 100, that is, the sample analysis device 10 may also be a sample analysis pipeline or a sample cascade system.

[0277] As an embodiment, the control device 400 is configured with a first standard sample measurement working mode and a second standard sample measurement working mode. The control device 400 adopts one of the first standard sample measurement working mode and the second standard sample measurement working mode to measure the loaded standard sample according to the feedback information of the second information acquisition component 500.

[0278] Reference Figure 1 , Fig. 9 , Fig.11 and Fig.13 As shown, the first standard sample determination working mode includes the following steps: the freeze-dried standard sample 40 is redissolved and restored to a liquid standard sample 50 by adding a re-solution, mixing, and standing, and is stored in the refrigeration mechanism 231 of the re-dissolution device 200. When the preset standard sample determination rule (such as the first preset condition mentioned above) is met for the first time, the control device 400 sends an instruction to the re-dissolution device 200 to call out the liquid standard sample 50. The liquid standard sample 50 is output by the re-dissolution device 200 to the transmission track 310, and is transported by the transmission track 310 to the loading area 111 of the sample measurement device 100. After the sample measurement device 100 completes sample suction and analysis, the liquid standard sample 50 is output by the sample measurement device 100 to the transmission track 310, and then returned to the re-dissolution device 200 by the transmission track 310 and stored in the refrigeration mechanism 231. When the preset standard sample measurement rules are met again, the liquid standard sample 50 in the refrigeration mechanism 231 is checked first. If it is within the validity period and the remaining amount is sufficient, the liquid standard sample 50 is directly transferred out, and the above scheduling steps are repeated to complete the standard sample measurement. If it is beyond the validity period or the remaining amount is insufficient, the freeze-dried standard sample 40 needs to be re-dissolved and restored, and the above re-dissolution and transfer steps are repeated.

[0279] Reference Figure 1 , Fig. 9 , Fig.11 and Fig.14As shown, in the second standard sample determination working mode, the operator can directly put the testable liquid standard sample 50 into the reconstitution device 200 and store it in the refrigerating mechanism 231. When the preset standard sample determination rule is met for the first time, the control device 400 sends a command to the reconstitution device 200 to call out the liquid standard sample 50. The liquid standard sample 50 is output by the reconstitution device 200 to the track of the transmission device 300, and is transported by the transmission device 300 to the loading area 111 of the sample determination device 100. After the sample determination device 100 completes the sample suction and analysis, the liquid standard sample 50 is output by the sample determination device 100 to the track of the transmission device 300, and then returned to the reconstitution device 200 by the track of the transmission device 300 and stored in the refrigerating mechanism 231. When the preset standard sample determination rule is met again, the liquid standard sample 50 in the refrigerating mechanism 231 is checked first. If it is within the validity period and the remaining amount is sufficient, the liquid standard sample 50 is directly called out, and the above scheduling steps are repeated to complete the determination of the standard sample. If the validity period has expired or the remaining quantity is insufficient, other newly loaded liquid standard samples 50 in the refrigeration mechanism 231 are used.

[0280] The main difference between the first standard sample determination working mode and the second standard sample determination working mode is that the standard samples put into the reconstitution device 200 by the operator are in different forms. Therefore, the reconstitution device 200 needs to additionally identify the form of the standard samples input from the outside. The identification method can be automatic identification, such as using visual recognition of the difference in the outer packaging of the standard samples or using a scanner to identify the difference in the identification code of the standard samples. The form of the standard samples input can also be specified by the operator, for example, when loading the standard samples, an interface for the standard sample type is provided for the operator to select.

[0281] The sample analysis device 10 provided in this embodiment includes the following key technical means and beneficial effects:

[0282] (1) The reconstitution device 200 can reconstitute the freeze-dried standard sample 40 input (i.e., put in) from the outside into a liquid standard sample 50 that can be tested on the machine according to a set program, and automatically transmit the liquid standard sample 50 to the sample measurement device 100 for measurement according to a first preset condition. On the one hand, it saves the complexity of manual operation, and on the other hand, it can also avoid the influence of human operation errors in the reconstitution process on the measurement results of the standard sample, thereby helping the laboratory to improve its quality management capabilities and efficiency.

[0283] (2) It can simultaneously support the placement of two different forms of standard samples, namely, freeze-dried standard samples 40 and liquid standard samples 50, to achieve the loading of standard samples.

[0284] (3) The reconstituted standard sample can be directly taken to the sample measuring device 100 for standard sample measurement without the need for secondary packaging into other containers, and without the need to remove the bottle cap 2202 or bottle stopper 2201 of the standard sample container (e.g., the first container 20) containing the standard sample, thereby making the measurement of the standard sample more convenient and helping to reduce the contact between the liquid standard sample 50 and the air, and making the performance more stable.

[0285] (4) The standard sample container loaded with the liquid standard sample 50 can be directly placed on the sample rack and dispatched to the sample aspiration position for sample aspiration.

[0286] Embodiment 2:

[0287] Reference Figure 1 , Fig.11 , Fig.13 , Fig.15 and Fig.16 As shown, the sample analysis device 10 provided in this embodiment is different from that in the first embodiment mainly in whether the freeze-dried standard sample 40 needs to be subpackaged after being reconstituted, which is specifically reflected in: in the first embodiment, the freeze-dried standard sample 40 does not need to be subpackaged after being reconstituted, and the original first container 20 of the freeze-dried standard sample 40 is directly used as a carrier to transfer the liquid standard sample 50 to the sample measuring device 100 for quality control measurement; while in the present embodiment, the freeze-dried standard sample 40 needs to be subpackaged after being reconstituted, and the liquid standard sample 50 is transferred to the sample measuring device 100 for quality control measurement using the second container after subpackage as a carrier.

[0288] As an implementation mode, in this embodiment, the standard sample container includes a first container 20 and a second container. The reconstitution device 200 includes a reconstitution solution dispensing mechanism 210 and a dispensing mechanism 270; the control of the reconstitution device 200 to reconstitute the freeze-dried standard sample 40 into a liquid standard sample 50 includes: controlling the reconstitution solution dispensing mechanism 210 to dispense the reconstitution solution into the freeze-dried standard sample 40 in the first container 20, so that the freeze-dried standard sample 40 and the reconstitution solution are mixed to form the liquid standard sample 50. The above-mentioned control of the transmission device 300 to transmit the standard sample container output from the reconstitution device 200 and loaded with at least a portion of the liquid standard sample 50 to the sample measuring device 100 includes: controlling the dispensing mechanism 270 to absorb at least a portion of the liquid standard sample 50 from the first container 20 and distribute it to at least one second container, and controlling the transmission device 300 to transmit the second container output from the reconstitution device 200 and loaded with at least a portion of the liquid standard sample 50 to the sample measuring device 100; in this embodiment, after controlling the reconstitution device 200 to reconstitute the freeze-dried standard sample 40 into the liquid standard sample 50, and before controlling the transmission device 300 to transmit at least a portion of the liquid standard sample 50 formed by reconstitution of the freeze-dried standard sample 40 from the reconstitution device 200 to the sample measuring device 100, the control of the dispensing mechanism 270 to absorb at least a portion of the liquid standard sample 50 from the first container 20 and distribute it to at least one second container. After the reconstitution device 200 automatically reconstitutes the freeze-dried standard sample 40 to form a liquid standard sample 50, it is automatically dispensed into the second container without the need for an operator to dispense, and the operation is simple and convenient.

[0289] As an embodiment, the shape, volume and material of the second container are the same as those of the first container 20, or at least one of the shape, volume and material of the second container is different from that of the first container 20. That is, the second container and the first container 20 can be the same container or two different containers.

[0290] As an embodiment, the volume of the second container is smaller than the volume of the first container 20. In this embodiment, after the reconstitution device 200 automatically reconstitutes the freeze-dried standard sample 40 in the first container 20 to form a liquid standard sample 50, it is automatically dispensed into a second container with a small volume, which is conducive to transferring the liquid standard sample 50 to the sample measurement device 100 as needed, avoiding multiple transfers and aspirations of the liquid standard sample 50 in the same container.

[0291] As an embodiment, the reconstitution solution dispensing mechanism 210 and the packaging mechanism 270 are the same mechanism, or the reconstitution solution dispensing mechanism 210 and the packaging mechanism 270 are two independent mechanisms, that is, the distribution of the reconstitution solution and the packaging of the reconstituted liquid standard sample 50 can be performed by the same mechanism or by different mechanisms.

[0292] As an embodiment, the reconstitution device 200 further includes a storage mechanism 230 and a second transfer mechanism 250, and the storage mechanism 230 includes a refrigeration mechanism 231 and / or a freezing mechanism 232. The storage temperature of the freezing mechanism 232 is lower than the storage temperature of the refrigeration mechanism 231. The storing of at least one second container loaded with the liquid standard sample 50 in the reconstitution device 200 includes: storing at least one second container loaded with the liquid standard sample 50 in the refrigeration mechanism 231 or the freezing mechanism 232. The above-mentioned control of the dispensing mechanism 270 to absorb at least a portion of the liquid standard sample 50 from the first container 20 and distribute it to at least one second container, and the control of the transmission device 300 to transfer the second container output from the re-dissolution device 200 and loaded with at least a portion of the liquid standard sample 50 to the sample measurement device 100 includes: controlling the dispensing mechanism 270 to absorb at least a portion of the liquid standard sample 50 from the first container 20 and distribute it to at least two second containers; when the first preset condition is met, controlling the transmission device 300 to transfer at least one second container output from the re-dissolution device 200 and loaded with a portion of the liquid standard sample 50 to the sample measurement device 100, and controlling the second transfer mechanism 250 to transfer at least one second container loaded with a portion of the liquid standard sample 50 to the refrigeration mechanism 231 and / or the freezing mechanism 232 for storage. In this embodiment, after controlling the dispensing mechanism 270 to absorb at least part of the liquid standard sample 50 from the first container 20 and distribute it to at least two second containers, the transmission device 300 is controlled to transmit at least one second container loaded with the liquid standard sample 50 from the reconstitution device 200 to the sample measuring device 100, and the at least one second container loaded with the liquid standard sample 50 is stored in the reconstitution device 200. The liquid standard sample 50 after dispensing does not need to be fully transmitted to the sample measuring device 100 at one time, and part of it can be stored in the storage mechanism 230 of the reconstitution device 200, which is conducive to ensuring the validity period of the liquid standard sample 50.

[0293] As an embodiment, the reconstitution device 200 also includes a rewarming mechanism 240; the control device 400 is also configured to: after controlling the second transfer mechanism 250 to transfer at least one second container loaded with a portion of the liquid standard sample 50 to the refrigeration mechanism 231 and / or the freezing mechanism 232 for storage, when the first preset condition is met again, determine whether the second container loaded with a portion of the liquid standard sample 50 and stored in the refrigeration mechanism 231 and / or the freezing mechanism 232 meets the third preset condition; if so, control the second transfer mechanism 250 to transfer the second container that meets the third preset condition from the refrigeration mechanism 231 or the freezing mechanism 232 to the rewarming mechanism 240 for temperature treatment; control the reconstitution device 200 to output the second container after the temperature treatment to the transmission device 300; control the transmission device 300 to transmit the second container output from the reconstitution device 200 and after the temperature treatment to the sample measurement device 100. In this embodiment, when the first preset condition is met and the standard sample measurement project needs to be performed, first check whether the liquid standard sample 50 reconstituted in the reconstitution device 200 and packaged in the second container meets the third preset condition. If it meets the third preset condition, the liquid standard sample 50 in the second container is preferentially transferred to the sample measurement device 100 for measurement to avoid the waste of the liquid standard sample 50; if it does not meet the third preset condition, the freeze-dried standard sample 40 needs to be reconstituted and packaged. In addition, in this embodiment, after the reconstituted and packaged liquid standard sample 50 is stored in the refrigeration mechanism 231 or the freezing mechanism 232, before it is needed, it is first heated by the rewarming mechanism 240 to restore the temperature of the liquid standard sample 50 to the preset range, thereby preventing the temperature of the liquid standard sample 50 from affecting the efficiency and results of the standard sample measurement.

[0294] As an embodiment, the third preset condition is that the amount of the liquid standard sample 50 loaded in the second container is greater than or equal to the amount of liquid standard sample 50 required for a quality control project or a calibration project. In this embodiment, when the first preset condition is met and the standard sample measurement project needs to be performed, first check whether the remaining amount of the liquid standard sample 50 reconstituted in the reconstitution device 200 and packaged in the second container is sufficient. If the remaining amount is sufficient, the liquid standard sample 50 in the second container is preferentially transferred to the sample measurement device 100 for measurement to avoid wasting the liquid standard sample 50; if the remaining amount is insufficient, the freeze-dried standard sample 40 needs to be reconstituted and packaged.

[0295] As an alternative implementation scheme of the third preset condition, the third preset condition is: the liquid volume of the liquid standard sample 50 loaded in the second container is greater than or equal to the demand for the liquid standard sample 50 for a quality control project or a calibration project, and the liquid standard sample 50 in the second container is within the validity period. In this embodiment, the third preset condition is not only sufficient residual quantity but also within the validity period. In this way, in a specific application, when the first preset condition is met and the standard sample measurement project needs to be performed, first check whether the liquid standard sample 50 reconstituted in the reconstitution device 200 and packaged in the second container is within the validity period and whether the residual quantity is sufficient. If it is within the validity period and the residual quantity is sufficient, the liquid standard sample 50 in the second container is preferentially transferred to the sample measurement device 100 for measurement to avoid waste of the liquid standard sample 50; if it exceeds the validity period or the residual quantity is insufficient, the freeze-dried standard sample 40 needs to be reconstituted and packaged.

[0296] As an embodiment, the control device 400 is configured with a second standard sample determination working mode and a third standard sample determination working mode. The control device 400 adopts one of the second standard sample determination working mode and the third standard sample determination working mode to perform quality control determination on the standard sample in the reconstitution device 200 according to the feedback information of the second information acquisition component 500. The second standard sample determination working mode can refer to the first embodiment and will not be described in detail here.

[0297] As an implementation method, refer to Figure 1 , Fig.11 , Fig.13 , Fig.15 and Fig.16As shown, the third standard sample determination working mode includes the following steps: the freeze-dried standard sample 40 in the first container 20 is redissolved and restored to a liquid standard sample 50 by adding a rehydrating solution, mixing, and standing, and is divided into a second container and stored in a rehydrating device 200; the divided and frozen liquid standard sample 50 is rehydrated into a liquid standard sample 50 by rewarming, mixing, and standing, and is stored in a refrigerating mechanism 231 of the rehydrating mechanism; when the preset standard sample determination rule (such as the above-mentioned After the first preset condition is met, the control device 400 sends an instruction to the reconstitution device 200 to call out the liquid standard sample 50. The liquid standard sample 50 is output by the reconstitution device 200 to the transmission track 310, and is transported by the transmission track 310 to the loading area 111 of the sample measurement device 100. After the sample measurement device 100 completes the sample suction and analysis, the liquid standard sample 50 is output by the sample measurement device 100 to the transmission track 310, and then is returned to the reconstitution device 200 by the transmission track 310 and stored in the refrigeration mechanism 231. When the preset standard sample measurement rules are met again, the liquid standard sample 50 in the refrigeration mechanism 231 is checked first. If it is within the validity period and the remaining amount is sufficient, the liquid standard sample 50 is directly called out, and the above scheduling steps are repeated to complete the measurement of the standard sample. If it exceeds the validity period or the remaining amount is insufficient, it is necessary to re-restore the frozen standard sample in the freezing mechanism 232 for a second time, and repeat the above rewarming and transporting steps. Or the freeze-dried standard sample 40 is re-reconstituted and restored and then packaged and frozen.

[0298] This embodiment supports re-dissolving and restoring the freeze-dried standard sample 40 and then packaging and freezing it for storage. When standard sample measurement is required, the frozen liquid standard sample 50 is re-warmed and restored for the second time. It is also compatible with the loading input of the liquid standard sample 50 and can automatically perform different standard sample measurement working modes according to the input standard sample type.

[0299] In addition to the above, other parts of the sample analysis device 10 provided in this embodiment can refer to the first embodiment and will not be described in detail here.

[0300] Embodiment three:

[0301] Reference Figure 1 , Fig.11 , Fig.12 and Figures 17 to 19 As shown, the sample analysis device 10 provided in this embodiment is different from that in the first embodiment mainly in that the arrangement of the pipette needle for distributing the liquid standard sample 50 and the method of aspirating the liquid standard sample 50 are different, which is specifically reflected in: in the first embodiment, the pipette needle for distributing the liquid standard sample 50 is a puncture needle, and there is no need to remove the cover and the plug when aspirating the liquid standard sample 50; while in the present embodiment, the pipette needle for distributing the liquid standard sample 50 is a non-puncture needle, and it is necessary to remove the cover and the plug before aspirating the liquid standard sample 50.

[0302] Specifically, in this embodiment, the standard sample container (e.g., the first container 20) has a bottle stopper 2201 and a bottle cap 2202, and the sample measurement device 100 further includes a pipetting mechanism, a stopper removal mechanism 190, and a cap removal mechanism 101. The cap removal mechanism 101 is used to remove the bottle cap 2202 of the standard sample container, and the stopper removal mechanism 190 is used to remove the bottle stopper 2201 of the standard sample container. The pipetting mechanism includes a second pipetting needle, which does not have a puncture function, that is, the second pipetting needle is a non-puncture needle, and the second pipetting needle is used to at least partially extend into the standard sample container after the bottle cap 2202 is removed by the stopper removal mechanism 101 and the bottle stopper 2201 is removed by the stopper removal mechanism 190, and at least a portion of the liquid standard sample 50 loaded therein is distributed into the first reaction container. In this embodiment, the liquid standard sample 50 is transported to the sample suction position using a standard sample container having a bottle stopper 2201 and a bottle cap 2202 as a carrier, and the pipetting mechanism uses a second pipetting needle without a puncture function to absorb and distribute the liquid standard sample 50, and the decapping mechanism 101 is used to remove the bottle cap 2202 of the standard sample container, and the deplugging mechanism 190 is used to remove the bottle stopper 2201 of the standard sample container, so that the second pipetting needle can absorb the liquid standard sample 50 from the standard sample container.

[0303] As an embodiment, the bottle cap 2202 is connected to the glass bottle body 21 by a threaded connection, and the decapping mechanism 101 clamps the bottle cap 2202 and rotates it to separate the bottle cap 2202 from the glass bottle body 21. The specific embodiment of decapping can be: the glass bottle body 21 is clamped by the first clamping mechanism 102, and the decapping mechanism 101 clamps the bottle cap 2202 and rotates it to rotate the bottle cap 2202 to separate from the glass bottle body 21. Of course, in specific applications, the arrangement of the decapping mechanism 101 is not limited to this.

[0304] As an embodiment, the bottle stopper 2201 is inserted into the bottle mouth of the glass bottle body 21 by means of interference fit. The decorking mechanism 190 includes a decorking needle 191 with a hollow interior, a lifting mechanism for driving the decorking needle 191 to move up and down, and a horizontal movement mechanism for driving the decorking needle 191 to move horizontally. The decorking needle 191 has a hollow inner hole 1911. The decorking needle 191 can penetrate the bottle stopper 2201 so that the interior of the first container 20 is connected to the external atmosphere to balance the air pressure. The decorking operation is as follows: the glass bottle body 21 is clamped and fixed by the second clamping mechanism 103, the lifting mechanism drives the decorking needle 191 to penetrate the bottle stopper 2201, and the lifting mechanism drives the decorking needle 191 to move upward. When the static friction force f between the decorking needle 191 and the bottle stopper 2201 is 1 Greater than the static friction force f between the bottle stopper 2201 and the glass bottle body 21 2When the bottle stopper 2201 is driven by the de-corking needle 191 to rise and separate from the glass bottle body 21, the horizontal moving mechanism drives the de-corking needle 191 with the bottle stopper 2201 to move to the preset de-corking station, and the lifting mechanism drives the de-corking needle 191 to move upward, so that the de-corking needle 191 and the bottle stopper 2201 are separated, and the bottle stopper 2201 is discarded. After the bottle stopper 2201 of the standard sample container is removed, the second pipetting needle can be normally extended into the standard sample container to absorb the liquid standard sample 50. Of course, in specific applications, the configuration of the de-corking mechanism 190 and the de-corking method are not limited to this.

[0305] In addition to the above, other parts of the sample analysis device 10 provided in this embodiment can refer to the first and second embodiments, and will not be described in detail here.

[0306] Embodiment 4:

[0307] Reference Figure 1 , Fig.11 , Fig.12 , Fig.17 , Fig. 20 and Fig.21 As shown, the sample analysis device 10 provided in this embodiment is different from the third embodiment mainly in that the sealing component 22 of the standard sample container and the sampling method of the liquid standard sample 50 are different, which is specifically reflected in: in the third embodiment, the sealing component 22 of the standard sample container includes a bottle stopper 2201 and a bottle cap 2202, and the sample needle used to distribute the liquid standard sample 50 is a non-puncture needle. Before the liquid standard sample 50 is sampled, it is necessary to remove the cover and the stopper; while in the present embodiment, the sealing component 22 of the standard sample container includes a bottle stopper 2201 but does not include a bottle cap 2202, and the pipetting needle used to distribute the liquid standard sample 50 is a non-puncture needle. Before the liquid standard sample 50 is sampled, it is necessary to remove the stopper.

[0308] Specifically, in this embodiment, the standard sample container (e.g., the first container 20) has a bottle stopper 2201, and the sample measurement device 100 further includes a plugging mechanism 190, which is used to remove the bottle stopper 2201 of the standard sample container, and the pipetting mechanism includes a second pipetting needle, which does not have a puncture function, and is used to at least partially extend into the standard sample container after the bottle stopper 2201 is removed by the plugging mechanism 190, and absorb at least part of the liquid standard sample 50 loaded therein and distribute it to the first reaction container. The setting method and plugging method of the plugging mechanism 190 in this embodiment can refer to the third embodiment, and will not be described in detail here.

[0309] In addition to the above, other parts of the sample analysis device 10 provided in this embodiment can refer to the first to third embodiments and will not be described in detail here.

[0310] Embodiment five:

[0311] The sample analysis device 10 provided in this embodiment is different from that in the first embodiment mainly in that the focus of protection is different, which is specifically reflected in that: in the first embodiment, the focus is on protecting the automatic re-dissolution function and automatic measurement after re-dissolution of the sample analysis device 10; while in this embodiment, the focus is on protecting the standard sample by loading it on the machine in its original container, the liquid standard sample 50 and the sample to be tested are cached in the same sample storage mechanism 110, and are dispatched to the sample suction position for sample suction by the same sample scheduling mechanism 120.

[0312] Specifically, the sample analysis device 10 provided in this embodiment includes a reconstitution device 200, a sample measuring device 100, a transmission device 300 and a control device 400. The reconstitution device 200 is used to reconstitute the freeze-dried standard sample 40 into a liquid standard sample 50. The sample measuring device 100 includes a sample storage mechanism 110 and a sample measuring mechanism 140. The sample storage mechanism 110 is used to store a sample container loaded with a sample to be tested, and the sample measuring mechanism 140 is used to measure at least part of the sample to be tested in the sample container from the sample storage mechanism 110 to obtain sample detection data. The transmission device 300 is used to: transmit the standard sample container output by the reconstitution device 200 and loaded with at least part of the liquid standard sample 50 formed by reconstitution of the freeze-dried standard sample 40 to the sample storage mechanism 110. The control device 400 is configured to: control the reconstitution device 200 to reconstitute the freeze-dried standard sample 40 into a liquid standard sample 50, control the transmission device 300 to transmit the standard sample container output from the reconstitution device 200 and loaded with at least part of the liquid standard sample 50 to the sample storage mechanism 110, and control the sample measurement mechanism 140 to measure at least part of the liquid standard sample 50 in the standard sample container from the sample storage mechanism 110 to obtain reference test data. In this embodiment, the freeze-dried standard sample 40 is loaded on the sample analysis device 10 with the standard sample container as a carrier. The freeze-dried standard sample 40 can be manually or automatically reconstituted into a liquid standard sample 50, and does not need to be repacked. The original standard sample container is directly used as a carrier of the liquid standard sample 50 for the sample measurement device 100 to absorb the liquid standard sample 50, thereby reducing the cumbersome operation of repackaging. In addition, the sample to be tested and the liquid standard sample 50 are waiting for loading in the same sample storage mechanism 110, and the sample scheduling mechanism 120 is conducive to simplifying the structure of the sample analysis device 10.

[0313] As an embodiment, the above-mentioned control transmission device 300 transfers the standard sample container output from the reconstitution device 200 and loaded with at least part of the liquid standard sample 50 to the sample storage mechanism 110, including: controlling the transmission device 300 to transfer the first sample rack 30 output from the reconstitution device 200 and loaded with the standard sample container to the sample storage mechanism 110. The sample storage mechanism 110 is used to store the first sample rack 30 from the transmission device 300 and loaded with the standard sample container, and the second sample rack loaded with the sample container and the sample container loaded with the sample to be tested. The first sample rack 30 has at least two first placement positions, each of which is used to place a single standard sample container, and the second sample rack has at least two second placement positions, each of which is used to place a single sample container.

[0314] As an embodiment, the first sample rack 30 and the second sample rack are two sample racks of the same shape and size. Of course, in a specific application, as an alternative embodiment, the first sample rack 30 and the second sample rack can also be two sample racks of different shapes and / or sizes.

[0315] As an embodiment, the sample measuring device 100 further includes a sample scheduling mechanism 120, which is used to schedule a second sample rack loaded with at least one sample container and a sample to be tested in the sample container to the second sample suction position of the sample dispensing mechanism 130, and is used to schedule a first sample rack 30 loaded with at least one standard sample container and a first container 20 loaded with a liquid standard sample 50 to the first sample suction position of the sample dispensing mechanism 130. In this embodiment, the liquid standard sample 50 and the sample to be tested are dispatched to the sample suction position using the same sample rack, which is conducive to simplifying the structure of the sample analysis device 10.

[0316] As an embodiment, the standard sample container includes a glass bottle body 21 and a sealing member 22. The glass bottle body 21 is formed with an inner cavity and a bottle mouth. The inner cavity is used to accommodate the freeze-dried standard sample 40 and to accommodate the liquid standard sample 50 formed by the reconstitution of the freeze-dried standard sample 40, that is, the inner cavity is used to provide a storage place for the freeze-dried standard sample 40 and the liquid standard sample 50. The bottle mouth is connected to the inner cavity to at least allow the liquid standard sample 50 to enter and exit the inner cavity. Specifically, the bottle mouth is used to at least allow at least part of the liquid standard sample 50 to be sucked out of the inner cavity. The sealing member 22 is used to seal the bottle mouth. The glass bottle body 21 can block moisture and oxygen, thereby extending the shelf life of the freeze-dried standard sample 40, and the size of the glass bottle body 21 is also ideal for the high-density freeze-dried standard sample 40. The glass bottle body 21 is a packaging form with better cost-effectiveness for the freeze-dried standard sample 40.

[0317] As an embodiment, the sample determination device 100 also includes a liquid transfer mechanism, and the liquid transfer mechanism includes a first liquid transfer needle, and the first liquid transfer needle has a puncture function. The first liquid transfer needle is at least used to puncture the bottle stopper 2201 and / or the bottle cap 2202 of the standard sample container to at least partially penetrate the standard sample container and absorb at least part of the liquid standard sample 50 loaded therein and distribute it to the first reaction container. In this embodiment, the standard sample container has a bottle cap 2202 and / or a bottle stopper 2201, and the re-dissolved liquid standard sample 50 does not need to be re-packed into other containers, and there is no need to remove the bottle stopper 2201 and / or the bottle cap 2202 loaded with the standard sample container. The liquid standard sample 50 is directly absorbed from the standard sample container through the bottle cap 2202 and the bottle stopper 2201 through the puncture needle, making the determination of the standard sample more convenient, and at the same time helping to reduce the contact between the liquid standard sample 50 and the air, so that the performance of the liquid standard sample 50 is more stable.

[0318] Of course, in specific applications, the method of aspirating the liquid standard sample 50 is not limited to this. For example, as an alternative implementation of the above-mentioned liquid standard sample 50 aspirating solution, the standard sample container has a bottle stopper 2201 and a bottle cap 2202, and the sample measuring device 100 further includes a pipetting mechanism, a plugging mechanism 190 and a capping mechanism 101. The capping mechanism 101 is used to remove the bottle cap 2202 of the standard sample container, and the plugging mechanism 190 is used to remove the bottle stopper 2201 of the standard sample container. The pipetting mechanism includes a second pipetting needle, which does not have a puncture function. The second pipetting needle is used to at least partially extend into the standard sample container after the bottle cap 2202 is removed by the plugging mechanism 101 and the bottle stopper 2201 is removed by the plugging mechanism 190, and aspirate at least a portion of the liquid standard sample 50 loaded therein and distribute it to the first reaction container. In this alternative implementation, the sample needle does not have a puncture function, and the capping and plugging operations need to be performed before aspirating the liquid standard sample 50 from the first standard sample container 20. The specific implementation method of removing the cover and the plug can refer to Example 3 and will not be described in detail here.

[0319] Alternatively, as another alternative embodiment of the above-mentioned liquid standard sample 50 sampling scheme, the standard sample container has a stopper 2201, and the sample measurement device 100 also includes a pipetting mechanism and a stopper removal mechanism 190. The stopper removal mechanism 190 is used to remove the stopper 2201 of the standard sample container. The pipetting mechanism includes a second pipetting needle, which does not have a puncture function. The second pipetting needle is used to at least partially extend into the standard sample container after the stopper 2201 is removed by the stopper removal mechanism 190, and to aspirate at least a portion of the liquid standard sample 50 loaded therein and distribute it into the first reaction container.

[0320] As an embodiment, the storage mechanism 230 reconstitution device 200 is disposed outside the sample measuring device 100, and the transmission device 300 is used to transmit the liquid standard sample 50 formed by reconstitution of the freeze-dried standard sample 40 in the standard sample container to the sample storage mechanism 110 of the sample measuring device 100. Of course, in a specific application, as an alternative embodiment, the storage mechanism 230 reconstitution device 200 can also be disposed inside the sample measuring device 100.

[0321] As an embodiment, the control device 400 is configured to: when a first preset condition is met, control the transmission device 300 to transmit the standard sample container loaded with the liquid standard sample 50 from the reconstitution device 200 to the sample storage mechanism 110 .

[0322] As an embodiment, the transport device 300 includes a transport track 310 , and the transport track 310 is used to carry the standard sample container output by the reconstitution device 200 and loaded with at least a portion of the liquid standard sample 50 , and transport it to the sample storage mechanism 110 .

[0323] In addition to the above, other parts of the sample analysis device 10 provided in this embodiment can refer to the first to fourth embodiments and will not be described in detail here.

[0324] Embodiment six:

[0325] The sample analysis device 10 provided in this embodiment is different from that in the first embodiment mainly in that the focus of protection is different, which is specifically reflected in that: in the first embodiment, the focus is on protecting the automatic re-dissolution function and automatic measurement after re-dissolution of the sample analysis device 10; while in this embodiment, the focus is on protecting the standard sample by using the original container to aspirate the sample.

[0326] Specifically, the sample analysis device 10 provided in this embodiment includes a storage mechanism 230 and a sample measuring device 100. The storage mechanism 230 is used for placing the first container 20 loaded with the freeze-dried standard sample 40 to realize the loading of the freeze-dried standard sample 40. The sample measuring device 100 includes a sample dispensing mechanism 130, a liquid transfer mechanism and a sample measuring mechanism 140. The sample dispensing mechanism 130 is used to absorb the sample to be tested from the sample container and distribute it to the second reaction container. The liquid transfer mechanism is used to distribute the liquid standard sample 50 formed by re-dissolving the freeze-dried standard sample 40 in the first container 20 to the first reaction container. The sample measuring mechanism 140 is used to measure the second reaction liquid made of at least the sample to be tested in the second reaction container and to measure the first reaction liquid made of at least the liquid standard sample 50 in the first reaction container. The liquid transfer mechanism and the sample dispensing mechanism 130 are the same mechanism or two independent mechanisms. In the present embodiment, the freeze-dried standard sample 40 is loaded into the sample analysis device 10 using the first container 20 as a carrier. The freeze-dried standard sample 40 can be reconstituted into a liquid standard sample 50 manually or automatically, and does not need to be repackaged. The original first container 20 is directly used as a carrier of the liquid standard sample 50 for the pipetting mechanism to absorb the liquid standard sample 50, thereby reducing the tedious operation of repackaging.

[0327] As one embodiment, the sample measuring device 100 also includes a sample scheduling mechanism 120, which is used to schedule a second sample rack loaded with at least one sample container and the sample container loaded with the sample to be tested to the second sample suction position of the sample distribution mechanism 130, and is used to schedule a first sample rack 30 loaded with at least one first container 20 and the first container 20 loaded with a liquid standard sample 50 to the first sample suction position of the sample distribution mechanism 130. The first sample rack 30 has at least two first placement positions, each of which is used to place a single standard sample container, and the second sample rack has at least two second placement positions, each of which is used to place a single sample container. The first sample rack 30 and the second sample rack are two sample racks of the same shape and size. In this embodiment, the liquid standard sample 50 and the sample to be tested are scheduled to the sample suction position using the same sample scheduling mechanism 120, which is conducive to simplifying the structure of the sample analysis device 10.

[0328] As an embodiment, the first sample rack 30 and the second sample rack are two sample racks of the same shape and size. In this embodiment, the liquid standard sample 50 and the sample to be tested use the same sample rack, which is conducive to simplifying the structure of the sample analysis device 10.

[0329] As an embodiment, the first container 20 includes a glass bottle body 21 and a sealing member 22, and the glass bottle body 21 is formed with an inner cavity and a bottle mouth. The inner cavity is used to accommodate the freeze-dried standard sample 40 and to accommodate the liquid standard sample 50 formed by re-dissolving the freeze-dried standard sample 40, that is, the inner cavity is used to provide a place to accommodate the freeze-dried standard sample 40 and the liquid standard sample 50. The bottle mouth is connected to the inner cavity to at least allow the freeze-dried standard sample 40 and the liquid standard sample 50 to enter and exit the inner cavity; specifically, the bottle mouth is used to allow at least part of the liquid standard sample 50 to be sucked out of the inner cavity. The sealing member 22 is used to seal the bottle mouth, and the sealing member 22 includes a bottle stopper 2201 at least partially penetrated in the bottle mouth and / or a bottle cap 2202 at least partially sleeved outside the bottle mouth. The glass bottle 21 can block moisture and oxygen, thereby extending the shelf life of the freeze-dried standard sample 40, and the size of the glass bottle 21 is also ideal for the high-density freeze-dried standard sample 40. The glass bottle 21 is a more cost-effective packaging form for the freeze-dried standard sample 40.

[0330] As an embodiment, the liquid transfer mechanism and the sample distribution mechanism 130 are the same mechanism. The sample distribution mechanism 130 includes a first sample needle, which has a puncture function. The first sample needle is at least used to puncture the bottle stopper 2201 and / or the bottle cap 2202 of the first container 20 to at least partially penetrate the first container 20, and absorb at least part of the liquid standard sample 50 loaded therein and distribute it to the first reaction container. In this embodiment, the first container 20 has a bottle cap 2202 and / or a bottle stopper 2201. The reconstituted standard sample does not need to be repacked into other containers, and there is no need to remove the bottle stopper 2201 and / or the bottle cap 2202 of the first container 20 loaded with the standard sample. The liquid standard sample 50 is directly absorbed from the first container 20 through the bottle cap 2202 and the bottle stopper 2201 through the puncture needle, making the determination of the standard sample more convenient, and at the same time helping to reduce the contact between the liquid standard sample 50 and the air, making the performance of the liquid standard sample 50 more stable.

[0331] Of course, in specific applications, the method of absorbing the liquid standard sample 50 is not limited to this. For example, as an alternative embodiment of the above-mentioned liquid standard sample 50 absorbing solution, the sealing member 22 includes a bottle stopper 2201 and a bottle cap 2202; the sample measuring device 100 also includes a plugging mechanism 190 and a capping mechanism 101, the capping mechanism 101 is used to remove the bottle cap 2202 of the first container 20, the plugging mechanism 190 is used to remove the bottle stopper 2201 of the first container 20, and the sample dispensing mechanism 130 includes a second sample needle, the second sample needle does not have a puncture function, and the second sample needle is used to at least partially extend into the first container 20 after the bottle cap 2202 is removed by the capping mechanism 101 and the bottle stopper 2201 is removed by the plugging mechanism 190, and absorb at least part of the liquid standard sample 50 loaded therein and distribute it to the first reaction container. In this alternative embodiment, the sample needle used to distribute the liquid standard sample 50 does not have a puncture function, and the capping and plugging operations need to be performed before the liquid standard sample 50 is absorbed from the first container 20. The specific implementation method of removing the cover and the plug can refer to Example 3 and will not be described in detail here.

[0332] Alternatively, as another alternative embodiment of the above-mentioned liquid standard sample 50 sampling scheme, the sealing component 22 includes a stopper 2201 but does not include a bottle cap 2202, the sample measuring device 100 also includes a stopper removal mechanism 190, the stopper removal mechanism 190 is used to remove the stopper 2201 of the first container 20, and the sample dispensing mechanism 130 includes a second sample needle, which is a non-puncture needle without a puncture function, and is used to at least partially extend into the first container 20 after the stopper 2201 is removed by the stopper removal mechanism 190, and to aspirate at least a portion of the liquid standard sample 50 loaded therein and distribute it to the first reaction container.

[0333] As an embodiment, the storage mechanism 230 is disposed outside the sample measuring device 100, and the sample analysis device 10 further includes a transmission device 300, which is used to transmit the liquid standard sample 50 formed by reconstitution of the freeze-dried standard sample 40 in the first container 20 to the sample measuring device 100. Of course, in a specific application, as an alternative embodiment, the storage mechanism 230 may also be disposed inside the sample measuring device 100.

[0334] As an embodiment, the sample analysis device 10 also includes a control device 400, which is configured to: when a first preset condition is met, control the transmission device 300 to transmit the liquid standard sample 50 formed by re-dissolving the freeze-dried standard sample 40 in the first container 20 to the sample measurement device 100.

[0335] In addition to the above, other parts of the sample analysis device 10 provided in this embodiment can refer to the first to fifth embodiments and will not be described in detail here.

[0336] Embodiment seven:

[0337] The sample analysis device 10 provided in this embodiment is different from that in the first embodiment mainly in that the focus of protection is different, which is specifically reflected in that: in the first embodiment, the focus is on protecting the automatic re-dissolution function and automatic measurement after re-dissolution of the sample analysis device 10; while in this embodiment, the focus is on protecting the standard sample from being automatically re-dissolved and dispatched to the sample suction position through the sample rack.

[0338] Specifically, the sample analysis device 10 provided in this embodiment includes a reconstitution device 200 and a sample measurement device 100, wherein the reconstitution device 200 is used to reconstitute the freeze-dried standard sample 40 into a liquid standard sample 50. The sample measurement device 100 is used to measure the sample to be tested to obtain sample test data, and is used to measure the liquid standard sample 50 to obtain reference test data. The sample measuring device 100 comprises a sample scheduling mechanism 120, a pipetting mechanism and a sample measuring mechanism 140. The sample scheduling mechanism 120 is used to schedule the first sample rack 30 so that the first sample rack 30 drives the standard sample container loaded therein to be scheduled to the first sample suction position. The standard sample container is loaded with at least a portion of the liquid standard sample 50 formed by re-dissolving the freeze-dried standard sample 40. The pipetting mechanism is used to absorb at least a portion of the liquid standard sample 50 loaded therein from the standard sample container located at the first sample suction position and distribute it to the first reaction container. The sample measuring mechanism 140 is used to measure the first reaction liquid in the first reaction container made of at least the liquid standard sample 50 distributed to the first reaction container. The first sample rack 30 has at least two first placement positions, and each of the first placement positions is used to place a single standard sample container. In this embodiment, after the standard sample is reconstituted, it is dispatched to the first sample suction position through the first sample rack 30, which is beneficial to utilize the sample measurement mechanism 140 to be reused for transmitting and dispatching standard sample containers, so that the sample analysis device 10 not only increases the function of automatic reconstitution of standard samples, but also does not cause major changes to the structure of the sample analysis device 10.

[0339] As an embodiment, the sample scheduling mechanism 120 is also used to schedule the second sample rack so that the second sample rack drives the sample container loaded with the sample to be tested to the second sample suction position; the second sample rack has at least two second placement positions, each second placement position is used to place a single sample container.

[0340] As an embodiment, the first sample rack 30 and the second sample rack are two sample racks of the same shape and size.

[0341] As an embodiment, the reconstitution device 200 includes a reconstitution solution dispensing mechanism 210 for dispensing the reconstitution solution into a standard sample container loaded with the freeze-dried standard sample 40 so that the freeze-dried standard sample 40 and the reconstitution solution are mixed to form a liquid standard sample 50 .

[0342] As an embodiment, the reconstitution device 200 also includes a mixing mechanism 220, which is used to mix the freeze-dried standard sample 40 and the reconstitution solution in the standard sample container after the reconstitution solution dispensing mechanism 210 dispenses the reconstitution solution into the standard sample container loaded with the freeze-dried standard sample 40.

[0343] The rehydration solution dispensing mechanism 210 and the liquid transfer mechanism are the same mechanism or two independent mechanisms.

[0344] As an implementation mode, the mixing mechanism 220 and the re-solution dispensing mechanism 210 are integrally provided; or, the mixing mechanism 220 and the re-solution dispensing mechanism 210 are independently provided.

[0345] As an embodiment, the mixing mechanism 220 mixes the freeze-dried standard sample 40 and the reconstituted solution in the first container 20 by at least one of shaking, vibrating, stirring, ultrasonic, suction and exhalation, and bubble blowing. When the mixing mechanism 220 mixes the freeze-dried standard sample 40 and the reconstituted solution in the first container 20 by shaking, the mixing mechanism 220 includes a manipulator for grabbing the first container 20 for shaking; when the mixing mechanism 220 mixes the freeze-dried standard sample 40 and the reconstituted solution in the first container 20 by suction and exhalation, the mixing mechanism 220 includes a pipette needle for suctioning and exhaling liquid from the first container 20.

[0346] In addition to the above, other parts of the sample analysis device 10 provided in this embodiment can refer to the first to sixth embodiments and will not be described in detail here.

[0347] Embodiment eight:

[0348] The sample analysis device 10 provided in this embodiment is different from that in the first embodiment mainly in that the focus of protection is different, which is specifically reflected in that: in the first embodiment, the focus is on protecting the automatic re-dissolution function and automatic measurement after re-dissolution of the sample analysis device 10; while in this embodiment, the focus is on protecting the standard sample from being automatically re-dissolved and then being transmitted to the sample measurement device 100 via the transmission track 310.

[0349] Specifically, the sample analysis device 10 provided in this embodiment includes a reconstitution device 200, a sample measuring device 100, a transmission device 300 and a control device 400. The reconstitution device 200 is used to reconstitute the freeze-dried standard sample 40 into a liquid standard sample 50; the sample measuring device 100 is located outside the reconstitution device 200, and the sample measuring device 100 is used to measure the sample to be tested to obtain sample test data, and to measure the liquid standard sample 50 to obtain reference test data; the transmission device 300 includes a transmission track 310, and the transmission track 310 is used to carry the sample output by the reconstitution device 200 and loaded with The standard sample container of at least a portion of the liquid standard sample 50 formed by the reconstitution of the freeze-dried standard sample 40 is transferred to the sample measuring device 100; the control device 400 is configured to: control the reconstitution device 200 to reconstitute the freeze-dried standard sample 40 into a liquid standard sample 50, control the transmission track 310 to transfer the standard sample container output from the reconstitution device 200 and loaded with at least a portion of the liquid standard sample 50 to the sample measuring device 100, and control the sample measuring device 100 to measure the first reaction liquid made of at least a portion of the liquid standard sample 50 transmitted from the transmission track 310 to obtain reference detection data. In this embodiment, the reconstituted liquid standard sample 50 is transmitted to the sample measuring device 100 through the transmission track 310 for measurement, which has a simple structure and low transmission cost.

[0350] As an embodiment, the standard sample container includes a first container 20 and / or a second container, and the reconstitution device 200 includes a storage mechanism 230, which is used to place the first container 20 loaded with the freeze-dried standard sample 40 to achieve the loading of the freeze-dried standard sample 40 and to place the third container loaded with the liquid standard sample 50 to achieve the loading of the liquid standard sample 50, and the storage mechanism 230 is used to store the first container 20 loaded with at least a portion of the liquid standard sample 50 formed by reconstitution of the freeze-dried standard sample 40, and / or to store the second container loaded with at least a portion of the liquid standard sample 50. The transfer track 310 is used to carry the first container 20 loaded with at least a portion of the liquid standard sample 50 formed by reconstitution of the freeze-dried standard sample 40 or the second container loaded with at least a portion of the liquid standard sample 50 formed by reconstitution of the freeze-dried standard sample 40 to the sample storage mechanism 110, and to carry the third container loaded with the liquid standard sample 50 to the sample storage mechanism 110.

[0351] As an embodiment, the control device 400 is further configured to control the transfer track 310 to carry the standard sample container output from the sample measuring device 100 and after at least part of the liquid standard sample 50 is measured by the sample measuring device 100, and transfer it to the reconstitution device 200 for storage or recovery.

[0352] As an embodiment, the reconstitution device 200 is located outside the sample measurement device 100 .

[0353] As an implementation mode, the reconstitution device 200 and the transfer track 310 are respectively distributed on two adjacent sides of the sample measurement device 100 .

[0354] In addition to the above, other parts of the sample analysis device 10 provided in this embodiment can refer to the first to seventh embodiments and will not be described in detail here.

[0355] The above description is only a preferred embodiment of the present invention, and does not limit the patent scope of the present invention. All equivalent structural changes made by using the contents of the present invention specification and drawings under the inventive concept of the present invention, or directly / indirectly applied in other related technical fields are included in the patent protection scope of the present invention.

Claims

1. A sample analysis device, characterized in that: include: A reconstitution device, wherein the reconstitution device is used to reconstitute the freeze-dried standard sample into a liquid standard sample; A sample measuring device, the sample measuring device is used to measure the sample to be measured to obtain sample test data, and is used to measure the liquid standard sample to obtain reference test data; A transmission device, the transmission device is used to: transmit the standard sample container output from the reconstitution device and loaded with at least a part of the liquid standard sample formed by reconstitution of the freeze-dried standard sample to the sample measurement device; A control device, wherein the control device is configured to: control the reconstitution device to reconstitute the freeze-dried standard sample into the liquid standard sample, control the transmission device to transmit the standard sample container output from the reconstitution device and loaded with at least a portion of the liquid standard sample to the sample measurement device, control the sample measurement device to absorb at least a portion of the liquid standard sample loaded in the standard sample container from the standard sample container and distribute it to a first reaction container, and control the sample measurement device to measure a first reaction liquid in the first reaction container made of at least the liquid standard sample distributed to the first reaction container to obtain the reference detection data.

2. The sample analysis device according to claim 1, characterized in that: The sample measuring device includes a sample storage mechanism, a sample scheduling mechanism, a sample distribution mechanism, a liquid transfer mechanism and a sample measuring mechanism; The controlling the transmission device to transmit the standard sample container output from the re-dissolving device and loaded with at least a portion of the liquid standard sample to the sample measuring device comprises: controlling the transmission device to transmit the standard sample container output from the re-dissolving device and loaded with at least a portion of the liquid standard sample to the sample storage mechanism; The sample storage mechanism is used to store a sample container loaded with a sample to be tested, and is used to store a standard sample container transferred by the transfer device and loaded with at least a portion of the liquid standard sample; The sample scheduling mechanism is used to schedule the standard sample container loaded with at least part of the liquid standard sample from the sample storage mechanism to a first sample suction position, and is used to schedule the sample container loaded with the sample to be tested from the sample storage mechanism to a second sample suction position, wherein the first sample suction position and the second sample suction position are located at the same position or at two different positions; The pipetting mechanism is used to draw at least a portion of the liquid standard sample loaded in the standard sample container located at the first sample aspiration position and distribute it into the first reaction container; The sample dispensing mechanism is used to absorb at least a portion of the sample to be tested loaded in the sample container located at the second sample aspirating position and distribute it to the second reaction container; The sample measuring mechanism is used to measure the first reaction liquid in the first reaction container which is at least made of the liquid standard sample distributed into the first reaction container, and is used to measure the second reaction liquid in the second reaction container which is at least made of the sample to be tested distributed into the second reaction container; Wherein, the pipetting mechanism and the sample dispensing mechanism are the same mechanism or two independent mechanisms; Preferably, the first reaction container and the second reaction container are two reaction containers of the same shape and size.

3. The sample analysis device according to claim 2, characterized in that: The controlling the transmission device to transmit the standard sample container output from the reconstitution device and loaded with at least a portion of the liquid standard sample to the sample storage mechanism comprises: controlling the transmission device to transmit the first sample rack output from the reconstitution device and loaded with the standard sample container to the sample storage mechanism; The sample storage mechanism is used to store the first sample rack from the transmission device and loaded with the standard sample container, and is used to store the second sample rack loaded with sample containers and the sample containers are loaded with samples to be tested; The sample scheduling mechanism is used to schedule the first sample rack so that the first sample rack from the sample storage mechanism drives the standard sample container loaded with at least part of the liquid standard sample to be scheduled to the first sample suction position, and is used to schedule the second sample rack so that the second sample rack from the sample storage mechanism drives the sample container loaded with the sample to be tested to be scheduled to the second sample suction position; The first sample rack has at least two first placement positions, each of which is used to place a single standard sample container, and the second sample rack has at least two second placement positions, each of which is used to place a single sample container; Preferably, the first sample rack and the second sample rack are two sample racks of the same shape and size.

4. The sample analysis device according to claim 1, characterized in that: The sample measuring device comprises a sample storage mechanism, a sample scheduling mechanism, a sample dispensing mechanism, a reagent dispensing mechanism, a liquid transfer mechanism and a sample measuring mechanism; The sample storage mechanism is used to store a sample container loaded with a sample to be tested; The sample dispatching mechanism is used to dispatch the sample container loaded with the sample to be tested from the sample storage mechanism to the second sample suction position; The sample dispensing mechanism is used to absorb at least a portion of the sample to be tested loaded in the sample container located at the second sample aspirating position and distribute it to the second reaction container; The controlling the transmission device to transmit the standard sample container output from the re-dissolving device and loaded with at least a portion of the liquid standard sample to the sample measuring device comprises: controlling the transmission device to transmit the standard sample container output from the re-dissolving device and loaded with at least a portion of the liquid standard sample to a third sample aspiration position, wherein the third sample aspiration position and the second sample aspiration position are located at the same position or at two different positions; The controlling the sample measuring device to draw at least a portion of the liquid standard sample loaded in the standard sample container from the standard sample container and distribute it to the first reaction container comprises: controlling the liquid transfer mechanism to draw at least a portion of the liquid standard sample loaded in the standard sample container located at the third sample aspiration position and distribute it to the first reaction container; The reagent dispensing mechanism is used to draw reagent from the reagent container and dispense it into the first reaction container, and is used to draw reagent from the reagent container and dispense it into the second reaction container; The sample measuring mechanism is used to measure the first reaction liquid in the first reaction container, which is at least the liquid standard sample distributed in the first reaction container and the reagent, and is used to measure the second reaction liquid in the second reaction container, which is at least the sample to be tested distributed in the second reaction container and the reagent; The liquid transfer mechanism and the reagent dispensing mechanism are the same mechanism or two independent mechanisms.

5. The sample analysis device according to claim 1, characterized in that: The sample measuring device comprises a reaction container supply mechanism, a sample dispensing mechanism and a pipetting mechanism, wherein the reaction container supply mechanism has one container output channel, and the container output channel is used to output the first reaction container and the second reaction container; The pipetting mechanism is used to draw at least a portion of the liquid standard sample loaded in the standard sample container and distribute it to the first reaction container outputted by the container output channel; The sample distributing mechanism is used to absorb at least a portion of the sample to be tested loaded in the sample container and distribute it to the second reaction container outputted by the container output channel.

6. The sample analysis device according to claim 1, characterized in that: The control device is further configured to control the transport device to transport the standard sample container output from the sample measuring device and after the liquid standard sample is sucked and dispensed by the sample measuring device to the reconstitution device for storage or recovery.

7. The sample analysis device according to any one of claims 1 to 6, characterized in that: The transmission device comprises a transmission track and a first transfer mechanism, and the transmission track is provided with a sample introduction position; The controlling the transmission device to transmit the standard sample container output from the reconstitution device and loaded with at least a portion of the liquid standard sample to the sample measurement device comprises: Control the transport track to transport the standard sample container output from the reconstitution device and loaded with at least a portion of the liquid standard sample to the sample injection position; The first transfer mechanism is controlled to transfer the standard sample container loaded with at least a portion of the liquid standard sample from the sample injection position to the sample measurement device.

8. The sample analysis device according to claim 7, characterized in that: The controlling the transport track to transport the standard sample container output from the reconstitution device and loaded with at least a portion of the liquid standard sample to the sample injection position includes: controlling the transport track to transport the first sample rack output from the reconstitution device and loaded with the standard sample container to the sample injection position; The controlling the first transfer mechanism to transfer the standard sample container loaded with at least a portion of the liquid standard sample from the sample injection position to the sample measurement device includes: controlling the first transfer mechanism to transfer the first sample rack loaded with the standard sample container and the standard sample container loaded with at least a portion of the liquid standard sample from the sample injection position to the sample measurement device.

9. The sample analysis device according to claim 7, characterized in that: The re-dissolving device and the transfer track are respectively distributed on two adjacent sides of the sample measuring device.

10. The sample analysis device according to claim 9, characterized in that: The sample measuring device comprises a sample storage mechanism, the sample storage mechanism comprises a loading area and an unloading area, the loading area and the unloading area are arranged at intervals along the transmission track, and the loading area and the unloading area are respectively arranged close to two ends of the transmission track, and the re-dissolving device is arranged close to the unloading area or the loading area; The sample introduction position is located at a position where the transmission track is directly opposite to the loading area; An entrance and an exit are formed at one end of the transport track away from the reconstitution device, and the entrance and an exit are at least used for inputting a second sample rack loaded with a sample container and the sample container loaded with a sample to be tested; The transfer track is used to: transfer the second sample rack loaded with the sample container from the entrance to the sample injection position along a first direction; The transport track is also used to: transport the first sample rack output from the reconstitution device and loaded with the standard sample container toward the inlet and outlet to the sample injection position along the second direction; The first transfer mechanism is used to transfer the first sample rack located at the sample injection position to the loading area, and is used to transfer the second sample rack located at the sample injection position to the loading area; The first direction and the second direction are two opposite directions.

11. The sample analysis device according to claim 9, characterized in that: The sample measuring device comprises a sample storage mechanism, the sample storage mechanism comprises a loading area and an unloading area, the loading area and the unloading area are arranged adjacent to or integrated with each other and are arranged close to the same end of the transmission track; The sample introduction position is located at a position where the transmission track is directly opposite to the loading area; The reconstitution device is disposed near one end of the transport track, and an inlet and outlet are formed at one end of the transport track away from the reconstitution device, and the inlet and outlet are at least used for inputting a second sample rack loaded with a sample container and the sample container loaded with a sample to be tested; The transfer track is used to: transfer the second sample rack loaded with the sample container from the entrance to the sample injection position along a first direction; The transport track is also used to: transport the first sample rack output from the reconstitution device and loaded with the standard sample container toward the inlet and outlet to the sample injection position along the second direction; The first transfer mechanism is used to transfer the first sample rack located at the sample injection position to the loading area, and is used to transfer the second sample rack located at the sample injection position to the loading area; The first direction and the second direction are two opposite directions.

12. The sample analysis device according to claim 10 or 11, characterized in that: The transport track is also used to transport the sample rack output from the unloading area toward the entrance and exit along the second direction; The sample analysis device further includes a first information acquisition component, which is disposed beside the transfer track or on the transfer track, and is used to acquire information of a sample rack output from the unloading area and transferred from the transfer track toward the entrance or exit, or to acquire information of a container loaded on a sample rack output from the unloading area and transferred from the transfer track toward the entrance or exit; The control device is also configured to: Determine the type of liquid loaded in the container on the sample rack output from the unloading area and transported toward the entrance and exit by the transport track, or determine the type of the container on the sample rack output from the unloading area and transported toward the entrance and exit by the transport track, according to the information of the sample rack or the information of the container fed back by the first information acquisition component; If it is determined that the type of the liquid loaded in the container on the sample rack is a sample to be tested or the type of the container loaded on the sample rack is a sample container, then control the transport track to transport the sample rack to the entrance and exit along the second direction for recycling; If the type of liquid loaded in the container on the sample rack is determined to be a liquid standard sample or the type of container loaded on the sample rack is determined to be a standard sample container, the transport track is controlled to transport the sample rack along the first direction to the reconstitution device for storage or recovery.

13. The sample analysis device according to any one of claims 1 to 6, characterized in that: The sample measuring device includes a sample storage mechanism, a sample scheduling mechanism, a sample distribution mechanism and a liquid transfer mechanism; The sample storage mechanism includes a loading area, an unloading area and a buffer area; The sample scheduling mechanism is used to schedule the first sample rack so that the first sample rack from the loading area drives the standard sample container loaded with at least part of the liquid standard sample to be scheduled to the first sample suction position, and is used to schedule the second sample rack so that the second sample rack from the loading area drives the sample container loaded with the sample to be tested to be scheduled to the second sample suction position; The pipetting mechanism is used to draw at least a portion of the liquid standard sample loaded in the standard sample container located at the first sample aspiration position and distribute it into the first reaction container; The sample dispensing mechanism is used to absorb at least a portion of the sample to be tested loaded in the sample container located at the second sample aspirating position and distribute it to the second reaction container; The control device is also configured to: Controlling the sample dispatching mechanism to dispatch the first sample rack loaded with the standard sample container after the standard sample container is sucked and dispensed with the liquid standard sample by the liquid transfer mechanism from the first sample suction position to the buffer area for buffering; If information is obtained that the liquid standard sample in at least one of the standard sample containers in the first sample rack cached in the cache area needs to be retested, the sample scheduling mechanism is controlled to schedule the first sample rack loaded with the standard sample container that needs to be retested from the cache area to the first sample aspirating position, and the liquid transfer mechanism is controlled to re-absorb and distribute at least a portion of the liquid standard sample loaded in the standard sample container that needs to be retested located at the first sample aspirating position; If information is obtained that the liquid standard samples in all the standard sample containers in the first sample rack cached in the cache area do not need to be retested, the sample scheduling mechanism is controlled to schedule the first sample rack from the cache area to the unloading area; The liquid transfer mechanism and the sample distribution mechanism are the same mechanism or two independent mechanisms.

14. The sample analysis device according to claim 1, characterized in that: The standard sample container comprises a first container; The controlling the re-dissolving device to re-dissolve the freeze-dried standard sample into the liquid standard sample comprises: controlling the re-dissolving device to re-dissolve the freeze-dried standard sample in the first container into the liquid standard sample; The controlling the transmission device to transmit the standard sample container output from the reconstitution device and loaded with at least a portion of the liquid standard sample to the sample measuring device comprises: controlling the transmission device to transmit the first container output from the reconstitution device and loaded with the liquid standard sample to the sample measuring device; The controlling the sample measuring device to draw at least a portion of the liquid standard sample loaded in the standard sample container and distribute it into the first reaction container includes: controlling the sample measuring device to draw at least a portion of the liquid standard sample loaded in the first container and distribute it into the first reaction container.

15. The sample analysis device according to claim 14, characterized in that: The controlling the transmission device to transmit the first container output from the re-dissolving device and loaded with the liquid standard sample to the sample measuring device comprises: when a first preset condition is met, controlling the transmission device to transmit the first container output from the re-dissolving device and loaded with the liquid standard sample to the sample measuring device; The controlling the sample measuring device to absorb at least a portion of the liquid standard sample loaded in the first container and distribute it to the first reaction container comprises: controlling the sample measuring device to absorb at least a portion of the liquid standard sample loaded in the first container and distribute it to the first reaction container; controlling the transmission device to transmit the first container output from the sample measuring device and after the sample measuring device absorbs and distributes at least a portion of the liquid standard sample to the reconstitution device for storage or recovery; The control device is further configured to: after controlling the transmission device to transmit the first container output from the sample measuring device and after the sample measuring device absorbs and dispenses at least a portion of the liquid standard sample to the reconstitution device for storage, when the first preset condition is met again, determine whether the first container output from the sample measuring device and after the sample measuring device absorbs and dispenses at least a portion of the liquid standard sample meets a second preset condition, and if so, control the reconstitution device to output the first container meeting the second preset condition to the transmission device, and control the transmission device to transmit the first container output from the reconstitution device and meeting the second preset condition to the sample measuring device; The second preset condition is that the amount of the liquid standard sample loaded in the first container is greater than or equal to the amount of the liquid standard sample required for a quality control item or a calibration item.

16. The sample analysis device according to claim 15, characterized in that: The reconstitution device comprises a storage mechanism, a reconstitution solution dispensing mechanism, a rewarming mechanism and a second transfer mechanism, wherein the storage mechanism comprises a refrigeration mechanism and / or a freezing mechanism; The controlling the reconstitution device to reconstitute the freeze-dried standard sample in the first container into the liquid standard sample comprises: controlling the reconstitution solution dispensing mechanism to dispense the reconstitution solution into the freeze-dried standard sample in the first container, so that the freeze-dried standard sample and the reconstitution solution are mixed to form the liquid standard sample; The controlling the transmission device to transmit the first container after the sample measuring device is output and after the sample measuring device absorbs and distributes at least a part of the liquid standard sample to the reconstitution device for storage or recovery includes: controlling the transmission device to transmit the first container after the sample measuring device is output and after the sample measuring device absorbs and distributes at least a part of the liquid standard sample to the refrigeration mechanism or the freezing mechanism for storage; The control device is also configured to: before controlling the re-dissolving device to output the first container that meets the second preset condition to the transmission device, control the second transfer mechanism to transfer the first container that meets the second preset condition from the refrigeration mechanism or the freezing mechanism to the rewarming mechanism for temperature rising treatment.

17. The sample analysis device according to claim 1, characterized in that: The standard sample container comprises a first container and a second container; The reconstitution device comprises a reconstitution solution dispensing mechanism and a dispensing mechanism; The controlling the reconstitution device to reconstitute the freeze-dried standard sample into the liquid standard sample comprises: controlling the reconstitution solution dispensing mechanism to dispense the reconstitution solution into the freeze-dried standard sample in the first container, so that the freeze-dried standard sample and the reconstitution solution are mixed to form the liquid standard sample; The controlling the transmission device to transmit the standard sample container output from the re-dissolving device and loaded with at least a portion of the liquid standard sample to the sample measuring device comprises: controlling the dispensing mechanism to absorb at least a portion of the liquid standard sample from the first container and distribute it to at least one of the second containers, and controlling the transmission device to transmit the second container output from the re-dissolving device and loaded with at least a portion of the liquid standard sample to the sample measuring device; The shape, volume and material of the second container are the same as those of the first container, or at least one of the shape, volume and material of the second container is different from that of the first container; The rehydration solution dispensing mechanism and the dispensing mechanism are the same mechanism or two independent mechanisms.

18. The sample analysis device according to claim 17, characterized in that: The reconstitution device further comprises a storage mechanism and a second transfer mechanism, wherein the storage mechanism comprises a refrigeration mechanism and / or a freezing mechanism; The step of controlling the dispensing mechanism to absorb at least a portion of the liquid standard sample from the first container and distribute it to at least one of the second containers, and controlling the transmission device to transmit the second container output from the reconstitution device and loaded with at least a portion of the liquid standard sample to the sample measurement device, comprises: Controlling the dispensing mechanism to absorb at least a portion of the liquid standard sample from the first container and distribute it to at least two of the second containers; When the first preset condition is met, the transmission device is controlled to transfer at least one second container output from the reconstitution device and loaded with a portion of the liquid standard sample to the sample measurement device, and the second transfer mechanism is controlled to transfer at least one second container loaded with a portion of the liquid standard sample to the refrigeration mechanism and / or freezing mechanism for storage.

19. The sample analysis device according to claim 18, characterized in that: The re-dissolving device also includes a re-temperature mechanism; The control device is also configured to: After controlling the second transfer mechanism to transfer at least one of the second containers loaded with a portion of the liquid standard sample to the refrigerating mechanism and / or freezing mechanism for storage, when the first preset condition is met again, determining whether the second container loaded with a portion of the liquid standard sample and stored in the refrigerating mechanism and / or freezing mechanism meets a third preset condition; If yes, controlling the second transfer mechanism to transfer the second container that meets the third preset condition from the refrigeration mechanism or the freezing mechanism to the rewarming mechanism for temperature raising treatment; Controlling the re-dissolving device to output the second container after the temperature increase treatment to the transmission device; Control the transport device to transport the second container output from the reconstitution device and subjected to the temperature increase process to the sample measuring device; The third preset condition is that the amount of the liquid standard sample loaded in the second container is greater than or equal to the amount of the liquid standard sample required for a quality control item or a calibration item.

20. The sample analysis device according to any one of claims 1 to 6 or any one of claims 14 to 19, characterized in that: The standard sample container comprises a glass bottle body and a sealing member, wherein the glass bottle body is formed with an inner cavity and a bottle mouth, wherein the inner cavity is used to accommodate the freeze-dried standard sample and is used to accommodate the liquid standard sample formed by reconstituting the freeze-dried standard sample, and the bottle mouth is connected with the inner cavity so that at least a part of the liquid standard sample can be sucked out of the inner cavity; The sealing component is used to seal the bottle mouth, and the sealing component includes a bottle plug at least partially penetrated into the bottle mouth and / or a bottle cap at least partially sleeved outside the bottle mouth.

21. The sample analysis device according to any one of claims 1 to 6 or any one of claims 14 to 19, characterized in that: The standard sample container has a bottle stopper and / or a bottle cap, the sample measuring device comprises a pipetting mechanism, the pipetting mechanism comprises a first pipetting needle, the first pipetting needle has a puncture function, the first pipetting needle is at least used to puncture the bottle stopper and / or the bottle cap of the standard sample container to at least partially penetrate the standard sample container and absorb at least part of the liquid standard sample loaded therein and distribute it into the first reaction container; or, The standard sample container has a bottle stopper, and the sample measuring device further comprises a pipetting mechanism and a de-stopper mechanism, wherein the de-stopper mechanism is used to remove the bottle stopper of the standard sample container, and the pipetting mechanism comprises a second pipetting needle, wherein the second pipetting needle does not have a puncture function, and the second pipetting needle is used to at least partially extend into the standard sample container after the bottle stopper is removed by the de-stopper mechanism, and absorb at least a part of the liquid standard sample loaded therein and distribute it into the first reaction container; or, The standard sample container has a bottle stopper and a bottle cap, and the sample measuring device also includes a pipetting mechanism, a plugging mechanism and a capping mechanism. The capping mechanism is used to remove the bottle cap of the standard sample container, and the plugging mechanism is used to remove the bottle stopper of the standard sample container. The pipetting mechanism includes a second pipetting needle, and the second pipetting needle does not have a puncture function. The second pipetting needle is used to at least partially extend into the standard sample container after the bottle cap is removed by the capping mechanism and the bottle stopper is removed by the plugging mechanism, and to absorb at least a part of the liquid standard sample loaded therein and distribute it into the first reaction container.

22. The sample analysis device according to any one of claims 1 to 6 or any one of claims 14 to 19, characterized in that: The standard sample container includes a first container and / or a second container, and the reconstitution device includes a storage mechanism, the storage mechanism is used for placing the first container loaded with the freeze-dried standard sample to achieve the loading of the freeze-dried standard sample, and the storage mechanism is used to store the first container loaded with at least part of the liquid standard sample formed by reconstitution of the freeze-dried standard sample, and / or the second container loaded with at least part of the liquid standard sample; The control of the transmission device to transmit the standard sample container output from the reconstitution device and loaded with at least a portion of the liquid standard sample to the sample measuring device includes: controlling the transmission device to transmit the first container output from the storage mechanism and loaded with at least a portion of the liquid standard sample to the sample measuring device, or controlling the transmission device to transmit the second container output from the storage mechanism and loaded with at least a portion of the liquid standard sample to the sample measuring device.

23. The sample analysis device according to claim 22, characterized in that: The storage mechanism is also used for placing a third container loaded with a liquid standard sample to achieve loading of the liquid standard sample; The control device is further configured to control the transport device to transport the third container output from the storage mechanism and loaded with the liquid standard sample to the sample measuring device.

24. The sample analysis device according to claim 23, characterized in that: The reconstitution device also includes a reconstitution solution dispensing mechanism; The sample analysis device further comprises a second information acquisition component, the second information acquisition component being used to acquire information of a container loaded with materials in the storage mechanism; The control device is also configured to: According to the information of the container fed back by the second information acquisition component, the type information of the standard sample loaded in the container loaded by the storage mechanism is obtained; When the standard sample loaded in the container loaded by the storage mechanism is a freeze-dried standard sample, controlling the reconstitution solution dispensing mechanism to dispense the reconstitution solution into the container, so that the freeze-dried standard sample and the reconstitution solution are mixed in the container to form the liquid standard sample; When the standard sample loaded in the container loaded by the storage mechanism is a liquid standard sample, the reconstitution solution dispensing mechanism is not controlled to dispense the reconstitution solution into the container.

25. The sample analysis device according to any one of claims 1 to 6 or any one of claims 14 to 19, characterized in that: The freeze-dried standard sample is a freeze-dried quality control product, and the reference test data is quality control data; Alternatively, the freeze-dried standard sample is a freeze-dried calibrator, and the reference detection data is calibration data.

26. The sample analysis device according to any one of claims 1 to 6 or any one of claims 14 to 19, characterized in that: The freeze-dried standard sample is a freeze-dried quality control product, and the reference test data is quality control data; The sample analysis device pre-stores at least one of the following first preset conditions: reaching a first preset time point of a first preset period, the cumulative running time of the sample measurement device since the last quality control item measurement reaches a first preset time, the number of times the sample measurement device continuously measures the sample to be measured reaches a first preset number of times, the number of times the sample measurement device cumulatively measures the sample to be measured reaches a second preset number of times since the last quality control item measurement, the reagent container is replaced to supply reagents, and the information on the execution of the quality control item is obtained according to the instructions input by the operator through the human-computer interaction device; The control device is further configured to: when any one or more of the first preset conditions are met, control the transmission device to transmit the standard sample container output from the reconstitution device and loaded with at least part of the quality control product to the sample measurement device.

27. The sample analysis device according to any one of claims 1 to 6 or any one of claims 14 to 19, characterized in that: The sample measuring device measures the liquid standard sample to obtain reference test data, including: the sample measuring device measures a first reaction liquid made of at least the liquid standard sample and a reagent to obtain the reference test data; The sample measuring device measures the sample to be measured to obtain sample detection data, including: the sample measuring device measures a second reaction liquid prepared by at least the sample to be measured and the reagent to obtain the sample detection data.

28. The sample analysis device according to any one of claims 1 to 6 or any one of claims 14 to 19, characterized in that: The re-dissolving device is arranged outside the sample measuring device; And / or, the sample test data includes coagulation item test data of the sample to be tested.

29. A sample analysis device, characterized in that: include: A reconstitution device, wherein the reconstitution device is used to reconstitute the freeze-dried standard sample into a liquid standard sample; A sample measuring device, the sample measuring device comprising a sample storage mechanism and a sample measuring mechanism, the sample storage mechanism is used to store a sample container loaded with a sample to be tested, and the sample measuring mechanism is used to measure at least part of the sample to be tested in the sample container from the sample storage mechanism to obtain sample detection data; A transmission device, the transmission device is used to: transmit the standard sample container output by the reconstitution device and loaded with at least a part of the liquid standard sample formed by reconstitution of the freeze-dried standard sample to the sample storage mechanism; A control device, wherein the control device is configured to: control the reconstitution device to reconstitute the freeze-dried standard sample into the liquid standard sample, control the transmission device to transmit the standard sample container output from the reconstitution device and loaded with at least a portion of the liquid standard sample to the sample storage mechanism, and control the sample measurement mechanism to measure at least a portion of the liquid standard sample in the standard sample container from the sample storage mechanism to obtain reference test data.

30. The sample analysis device according to claim 29, characterized in that: The controlling the transmission device to transmit the standard sample container output from the re-dissolving device and loaded with at least a portion of the liquid standard sample to the sample storage mechanism includes: controlling the transmission device to transmit the first sample rack output from the re-dissolving device and loaded with the standard sample container to the sample storage mechanism; The sample storage mechanism is used to store the first sample rack from the transmission device and loaded with the standard sample container, and is used to store the second sample rack loaded with sample containers and the sample containers are loaded with the samples to be tested; The first sample rack has at least two first placement positions, each of which is used to place a single standard sample container, and the second sample rack has at least two second placement positions, each of which is used to place a single sample container; Preferably, the first sample rack and the second sample rack are two sample racks of the same shape and size.

31. The sample analysis device according to claim 29 or 30, characterized in that: The reconstitution device is located outside the sample determination device; And / or, the transmission device includes a transmission track, and the transmission track is used to carry the standard sample container output by the reconstitution device and loaded with at least a part of the liquid standard sample, and transmit it to the sample storage mechanism.

32. A sample analysis device, characterized in that: include: A reconstitution device, wherein the reconstitution device is used to reconstitute the freeze-dried standard sample into a liquid standard sample; A sample measuring device, the sample measuring device is used to measure the sample to be measured to obtain sample test data, and is used to measure the liquid standard sample to obtain reference test data; The sample measuring device comprises a sample scheduling mechanism, a liquid transfer mechanism and a sample measuring mechanism, wherein the sample scheduling mechanism is used to schedule a first sample rack so that the first sample rack drives a standard sample container loaded therein to be scheduled to a first sample suction position, wherein the standard sample container is loaded with at least a portion of the liquid standard sample formed by reconstituting the freeze-dried standard sample, the liquid transfer mechanism is used to draw at least a portion of the liquid standard sample loaded therein from the standard sample container located at the first sample suction position and distribute it to a first reaction container, and the sample measuring mechanism is used to measure a first reaction liquid in the first reaction container made of at least the liquid standard sample distributed to the first reaction container; The first sample rack has at least two first placement positions, and each of the first placement positions is used to place a single standard sample container.

33. The sample analysis device according to claim 32, characterized in that: The re-dissolving device comprises: a rehydration solution dispensing mechanism, the rehydration solution dispensing mechanism being used to dispense the rehydration solution into the standard sample container loaded with the freeze-dried standard sample, so that the freeze-dried standard sample and the rehydration solution are mixed to form the liquid standard sample; a mixing mechanism, the mixing mechanism being used to mix the freeze-dried standard sample and the reconstitution solution in the standard sample container after the reconstitution solution dispensing mechanism dispenses the reconstitution solution into the standard sample container loaded with the freeze-dried standard sample; Wherein, the rehydration solution dispensing mechanism and the pipetting mechanism are the same mechanism or two independent mechanisms.

34. The sample analysis device according to claim 33, characterized in that: The mixing mechanism is integrally arranged with the re-solution dispensing mechanism; Alternatively, the mixing mechanism and the re-solution dispensing mechanism are arranged independently of each other.

35. A sample analysis device, characterized in that: include: A reconstitution device, wherein the reconstitution device is used to reconstitute the freeze-dried standard sample into a liquid standard sample; A sample measuring device, the sample measuring device is located outside the reconstitution device, the sample measuring device is used to measure the sample to be measured to obtain sample test data, and is used to measure the liquid standard sample to obtain reference test data; A transmission device, the transmission device comprising a transmission track, the transmission track is used to carry the standard sample container output by the reconstitution device and loaded with at least a part of the liquid standard sample formed by reconstitution of the freeze-dried standard sample, and transmit it to the sample measurement device; A control device, wherein the control device is configured to: control the reconstitution device to reconstitute the freeze-dried standard sample into the liquid standard sample, control the transmission track to transfer the standard sample container output from the reconstitution device and loaded with at least a portion of the liquid standard sample to the sample measurement device, and control the sample measurement device to measure a first reaction liquid made from at least a portion of the liquid standard sample transmitted from the transmission track to obtain the reference detection data.

36. The sample analysis device according to claim 35, characterized in that: The standard sample container includes a first container and / or a second container, and the reconstitution device includes a storage mechanism, the storage mechanism is used for placing the first container loaded with the freeze-dried standard sample to realize the loading of the freeze-dried standard sample and for placing the third container loaded with the liquid standard sample to realize the loading of the liquid standard sample, and the storage mechanism is used to store the first container loaded with at least part of the liquid standard sample formed by reconstitution of the freeze-dried standard sample, and / or the second container loaded with at least part of the liquid standard sample; The transfer track is used to carry the first container loaded with at least a portion of the liquid standard sample formed by reconstituting the freeze-dried standard sample or the second container loaded with at least a portion of the liquid standard sample formed by reconstituting the freeze-dried standard sample to the sample storage mechanism, and to carry the third container loaded with the liquid standard sample to the sample storage mechanism.

37. The sample analysis device according to claim 35 or 36, characterized in that: The control device is further configured to: control the transport track to carry the standard sample container output from the sample measuring device and after at least a portion of the liquid standard sample has been measured by the sample measuring device, and transport it to the reconstitution device for storage or recovery; And / or, the re-dissolution device and the transfer track are respectively distributed on two adjacent sides of the sample determination device.

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