A full-view three-dimensional lipid optical imaging system and device

Abstract

The application discloses a full-view three-dimensional lipid optical imaging system and equipment, and belongs to the field of optical imaging technology.The imaging system comprises a laser exit unit, a one-to-N optical fiber bundle, a ring-shaped ultrasonic transducer, a control unit, a liquid container and a water level control unit; the liquid container contains acoustic-conducting liquid; the control unit outputs water level control information, and the water level control unit controls the imaging surface of the ring-shaped ultrasonic transducer to be flush with the horizontal surface of the acoustic-conducting liquid according to the water level control information; a ring-shaped light beam emitted by the laser exit unit passes through a target to be detected to the imaging surface of the ring-shaped ultrasonic transducer, and generates a plurality of photoacoustic signals; the ring-shaped ultrasonic transducer receives the photoacoustic signals and generates electric signals; the control unit receives the electric signals, carries out signal processing and image reconstruction, and forms a three-dimensional lipid image of the target to be detected, so that full-view imaging of the target to be detected is realized, the excitation efficiency of the photoacoustic signals is ensured, the absorption of the acoustic-conducting liquid is reduced, and the imaging effect is ensured.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of photoacoustic imaging, in particular to a full-view three-dimensional lipid optical imaging system and device. BACKGROUND

[0002] Photoacoustic imaging is a non-invasive imaging technique combining laser excitation and ultrasonic detection, which is widely used in medical, biological and material science fields. It has both strong deep tissue imaging capability of ultrasound and high resolution and high contrast of optics, and can also combine multi-wavelength scanning to realize photoacoustic spectral imaging and functional information extraction capability.

[0003] At present, three-dimensional lipid scanning has important significance in the diagnosis and treatment of lipid-related diseases and health management. Lipid metabolism disorder is closely related to the occurrence and development of many diseases, such as cardiovascular disease, obesity, diabetes, etc. Although traditional fat detection methods such as body fat meter, CT and MRI can provide certain degree of fat distribution information, there are drawbacks in accuracy, safety, cost or operation complexity. Photoacoustic imaging technology has great application potential in lipid imaging due to its unique advantages, but the existing implementation method selects a linear array ultrasonic transducer and realizes three-dimensional lipid photoacoustic imaging by scanning each cross section through the linear array ultrasonic transducer, which has low efficiency of laser excitation sound signal and limited imaging view angle. SUMMARY

[0004] The present application provides a full-view three-dimensional lipid optical imaging system and device to improve the excitation efficiency of photoacoustic signals, while ensuring the imaging view angle, and thus improving the three-dimensional lipid optical imaging effect.

[0005] According to one aspect of the present application, a full-view three-dimensional lipid optical imaging system is provided, comprising: a laser exit unit, a one-to-N optical fiber bundle, a ring-shaped ultrasonic transducer, a control unit, a liquid container and a water level control unit;

[0006] The exit end of the laser exit unit is connected with the input end of the one-to-N optical fiber bundle; the control unit is connected with the ring-shaped ultrasonic transducer and the water level control unit respectively; the water level control unit is connected with the ring-shaped ultrasonic transducer and the water level control unit respectively, and the liquid container contains acoustic-conducting liquid;

[0007] The ring-shaped ultrasonic transducer comprises a ring-shaped portion and a center hollow portion, the center hollow portion is used for placing a target to be detected, and N output ends of the one-to-N optical fiber bundle are uniformly distributed on the ring-shaped portion and face the center hollow portion, and the laser beams emitted by the N output ends form a ring-shaped beam, wherein N is greater than or equal to 3;

[0008] The annular ultrasonic transducer and at least part of the target to be detected are immersed in the acoustic-conducting liquid; the control unit outputs water level control information, and a water level control unit controls the imaging surface of the annular ultrasonic transducer to be flush with the horizontal plane of the acoustic-conducting liquid according to the water level control information.

[0009] The annular light beam passes through the target to be detected to the imaging surface of the annular ultrasonic transducer, and generates a plurality of photoacoustic signals, the annular ultrasonic transducer receives the photoacoustic signals and generates an electrical signal, the control unit receives the electrical signal and performs signal processing and image reconstruction to form a three-dimensional lipid image of the target to be detected.

[0010] Optionally, the water level control unit at least includes a first motor, a second motor and a liquid level adjusting tank; the liquid level adjusting tank is at least partially immersed in the acoustic-conducting liquid.

[0011] The control unit is connected with the first motor and the second motor respectively, the first motor is connected with the annular ultrasonic transducer, and the first motor is used to control the lifting state of the annular transducer; the second motor is connected with the liquid level adjusting tank, and the second motor is used to control the lifting state of the liquid level adjusting tank; wherein the moving direction of the annular ultrasonic transducer is opposite to the moving direction of the liquid level adjusting tank.

[0012] Optionally, the first motor and the second motor are started synchronously.

[0013] Optionally, the cross-sectional area of the liquid container along the first direction is S1, the running speed of the first motor is V1, the cross-sectional area of the liquid level adjusting tank along the first direction is S2, and the running speed of the second motor is V2, wherein S1*V1=S2*V2.

[0014] Wherein, the first direction is parallel to the direction along the horizontal plane of the acoustic-conducting liquid.

[0015] Optionally, the included angle between the light emitting direction of the N output ends of the one N optical fiber bundle and the plane where the acoustic-conducting liquid is located is θ, wherein 30°≤θ≤60°.

[0016] Optionally, the laser emitting unit includes a laser source, a half-wave plate, a Glan prism and a fiber coupler arranged in sequence along the light path, the laser source emits a first laser beam, the first laser beam is sequentially subjected to energy adjustment by the half-wave plate and the Glan prism to generate a second laser beam which is emitted to the fiber coupler, and the fiber coupler couples the second laser beam to the one N optical fiber bundle.

[0017] Optionally, the wavelength of the first laser beam is λ, wherein 1180≤λ≤2500nm.

[0018] Optionally, the laser source emits the first laser beam of the same wavelength within a preset time; or the laser source cyclically emits the first laser beam of different wavelengths within a preset time.

[0019] Optionally, the annular portion is provided with a plurality of ultrasonic transducer elements arranged in a circumferential array.

[0020] According to another aspect of the present application, there is provided a full-view three-dimensional lipid optical imaging device comprising the full-view three-dimensional lipid optical imaging system of any one of the above aspects.

[0021] The technical scheme of the embodiment of the present application provides a full-view three-dimensional lipid optical imaging system, which comprises a laser emission unit, a one-to-N optical fiber bundle, an annular ultrasonic transducer, a control unit, a liquid container and a water level control unit; the emission end of the laser emission unit is connected with the input end of the one-to-N optical fiber bundle; the control unit is connected with the annular ultrasonic transducer and the water level control unit respectively; the water level control unit is connected with the ultrasonic transducer and the water level control unit respectively, and the liquid container contains acoustic-conducting liquid; the annular ultrasonic transducer comprises an annular portion and a central hollow portion, the central hollow portion is used for placing a target to be detected, the N output ends of the one-to-N optical fiber bundle are uniformly distributed on the annular portion and face the central hollow portion, and the laser beams emitted by the N output ends form an annular beam, wherein N is greater than or equal to 3; at least part of the annular ultrasonic transducer and the target to be detected are immersed in the acoustic-conducting liquid; the control unit outputs water level control information, and the water level control unit controls the imaging surface of the annular ultrasonic transducer to be flush with the horizontal surface of the acoustic-conducting liquid according to the water level control information; the annular beam passes through the target to be detected to the imaging surface of the annular ultrasonic transducer, and generates a plurality of photoacoustic signals, the annular ultrasonic transducer receives the photoacoustic signals and generates electric signals, the control unit receives the electric signals and performs signal processing and image reconstruction to form a three-dimensional lipid image of the target to be detected, thereby realizing full-view imaging of the target to be detected. At the same time, the excitation efficiency of the photoacoustic signal is ensured, the absorption of the acoustic-conducting liquid is reduced, and the imaging effect is ensured.

[0022] It should be understood that the content described in this part is not intended to identify key or important features of the embodiments of the present application, nor is it used to limit the scope of the present application. Other features of the present application will become apparent from the following description. BRIEF DESCRIPTION OF DRAWINGS

[0023] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following will briefly introduce the drawings needed to be used in the embodiment description. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can also be obtained by those skilled in the art without creating laborious work.

[0024] Figure 1 This is a schematic diagram of the structure of a full-view three-dimensional lipid optical imaging system provided in an embodiment of the present invention;

[0025] Figure 2 This invention provides a full-view three-dimensional lipid photoacoustic image of different cross sections when the target to be tested is a plastic tube phantom containing peanut oil and the laser beam wavelength is 1210nm.

[0026] Figure 3 This invention provides a full-view three-dimensional lipid photoacoustic image of different cross sections when the target is a mouse and the laser beam wavelength is 1210nm;

[0027] Figure 4 This invention provides a full-view three-dimensional lipid photoacoustic image of different cross sections when the target is a mouse and the laser beam has multiple wavelengths. Detailed Implementation

[0028] To enable those skilled in the art to better understand the present invention, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort should fall within the scope of protection of the present invention.

[0029] It should be noted that the terms "first," "second," etc., in the specification, claims, and accompanying drawings of this invention are used to distinguish similar objects and are not necessarily used to describe a specific order or sequence. It should be understood that such data can be interchanged where appropriate so that the embodiments of the invention described herein can be implemented in orders other than those illustrated or described herein. Furthermore, the terms "comprising" and "having," and any variations thereof, are intended to cover a non-exclusive inclusion; for example, a process, method, system, product, or apparatus that comprises a series of steps or units is not necessarily limited to those steps or units explicitly listed, but may include other steps or units not explicitly listed or inherent to such processes, methods, products, or apparatus.

[0030] Figure 1 This is a schematic diagram of a full-view three-dimensional lipid optical imaging system provided in an embodiment of the present invention. This embodiment is applicable to full-view three-dimensional lipid photoacoustic imaging. The full-view three-dimensional lipid optical imaging system 100 can be implemented in hardware and / or software, such as... Figure 1As shown, the full-view three-dimensional lipid optical imaging system 100 includes: a laser emission unit 101, a one-to-N fiber bundle 102, a ring ultrasonic transducer 103, a control unit 104, a liquid container 105, and a water level control unit 106; the emission end of the laser emission unit 101 is connected to the input end of the one-to-N fiber bundle 102; the control unit 104 is connected to both the ring ultrasonic transducer 103 and the water level control unit 106; the water level control unit 106 is connected to both the ring ultrasonic transducer 103 and the water level control unit 106; the liquid container 105 contains acoustically conductive liquid 107; the ring ultrasonic transducer 103 includes a ring portion 1031 and a central hollow portion 1032, the central hollow portion 1032 being used to place the target to be detected 10; the one-to-N fiber bundle 102... N output ends are evenly distributed on the annular portion 1031 and face the central hollow portion 1032. The laser beams emitted from the N output ends form an annular beam, where N≥3. At least a portion of the annular ultrasonic transducer 103 and the target 10 to be detected are immersed in the acoustic guiding liquid 107. The control unit 104 outputs water level control information, and the water level control unit 106 controls the imaging surface of the annular ultrasonic transducer 103 to be flush with the horizontal surface of the acoustic guiding liquid 107 according to the water level control information. The annular beam passes through the target 10 to the imaging surface of the annular ultrasonic transducer 103 and generates multiple photoacoustic signals. The annular ultrasonic transducer 103 receives the photoacoustic signals and generates electrical signals. The control unit 104 receives the electrical signals and performs signal processing and image reconstruction to form a three-dimensional lipid image of the target 10 to be detected.

[0031] The system comprises a laser emission unit 101, a one-to-N fiber bundle 102, a ring ultrasonic transducer 103, a control unit 104, a liquid container 105, and a water level control unit 106. The liquid container 105 contains a sound-conducting liquid 107, which can be water or an ultrasonic coupling agent. The specific material of the sound-conducting liquid 107 can be selected according to actual design requirements, and this embodiment of the invention does not impose specific limitations. The ring ultrasonic transducer 103 includes a ring portion 1031 and a central hollow portion 1032. For example, the inner and outer circumferences of the ring portion 1031 are both circular, or the inner circumference of the ring portion 1031 is circular and the outer circumference is rectangular. The ring portion 1031 allows the output ends of the one-to-N fiber bundle 102 to be evenly distributed on the ring portion 1031. For example, N equals 10, and the one-to-N fiber bundle 1021 is a one-to-one fiber bundle, thereby achieving the formation of a ring beam to ensure full-view three-dimensional lipid imaging of the target 10. The central hollow portion 1032 of the annular ultrasonic transducer 103 is used to place the target 10 to be tested. The target 10 is partially immersed in the acoustic conductive liquid 107 and partially exposed to the air, thereby ensuring subsequent scanning and imaging of the target 10. The output end of the laser emission unit 101 is connected to the input end of the N-way fiber bundle 102. The laser emission unit 101 emits a laser beam, and the N-way fiber bundle 102 receives the laser beam and splits it so that it is output along different output ends. Since the output ends of the N-way fiber bundle 102 are evenly distributed along the annular portion of the annular ultrasonic transducer 103, the laser beams output from the N output ends form an annular beam. The control unit 104 is connected to the water level control unit 106. Part of the annular ultrasonic transducer 103 is immersed in the acoustic guiding liquid 107, and part is exposed to the air. The control unit 104 outputs water level control information, and the water level control unit 106 controls the imaging surface of the annular ultrasonic transducer 103 to be flush with the horizontal surface of the acoustic guiding liquid 107 according to the water level control information. This ensures that when scanning and imaging the target 10, the liquid level of the acoustic guiding liquid 107 in the liquid container 105 is stably maintained on the imaging surface of the annular ultrasonic transducer 103, reducing the absorption of the annular beam by the acoustic guiding liquid 107 and ensuring the excitation effect of the acoustic and optical signals. Simultaneously, the control unit 104 is connected to the water level control unit 106. The control unit 104 receives the electrical signal fed back from the annular ultrasonic transducer 103 and performs signal processing and image reconstruction algorithms to generate multiple lipid photoacoustic images of the target 10 under different wavelength excitation. By spectrally demixing the multiple photoacoustic images, the lipid photoacoustic images of the target 10 at different cross sections are obtained, ultimately yielding a full-view three-dimensional lipid photoacoustic image of the target 10. For example... Figure 2 This invention provides a full-view three-dimensional lipid photoacoustic image of different cross-sections of a plastic tube phantom containing peanut oil, with a laser beam wavelength of 1210 nm, as an embodiment of the invention.Figure 2 As shown in the figure, the white area in the center is clearly the lipid distribution area, which is where the peanut oil is located. Figure 3 This invention provides a full-view three-dimensional lipid photoacoustic image of different cross sections when the target is a mouse and the laser beam wavelength is 1210 nm, as shown in the embodiment of the invention. Figure 3 As shown, the scanning range is from the mouse's thoracic cavity to its tail, from... Figure 3 The white area can be clearly seen as the lipid distribution area.

[0032] This invention, through the configuration of a full-view three-dimensional lipid optical imaging system, includes a laser emission unit, a one-to-N fiber bundle, a ring ultrasonic transducer, a control unit, a liquid container, and a water level control unit. By rationally controlling the distribution of the output end of the one-to-N fiber bundle within the ring portion of the ring ultrasonic transducer, the emitted laser beam forms a ring beam, illuminating the target located in the central hollow portion of the ring ultrasonic transducer. Multiple photoacoustic signals are generated on the imaging surface of the ring ultrasonic transducer. The ring ultrasonic transducer receives these photoacoustic signals and generates electrical signals. The control unit receives the electrical signals and performs signal processing and image reconstruction to form a three-dimensional lipid image of the target, achieving full-view imaging of the target. Simultaneously, the excitation efficiency of the photoacoustic signals is ensured, and the absorption by the acoustically conductive liquid is reduced, guaranteeing imaging quality.

[0033] Optionally, the water level control unit 106 includes at least a first motor 1061, a second motor 1062, and a liquid level regulating tank 1063; the liquid level regulating tank 1063 is at least partially immersed in the sound-conducting liquid 107; the control unit 104 is connected to the first motor 1061 and the second motor 1062 respectively, the first motor 1061 is connected to the annular ultrasonic transducer 103, and the first motor 1061 is used to control the lifting and lowering state of the annular transducer; the second motor 1062 is connected to the liquid level regulating tank 1063, and the second motor 1062 is used to control the lifting and lowering state of the liquid level regulating tank 1063; wherein, the moving direction of the annular ultrasonic transducer 103 is opposite to the moving direction of the liquid level regulating tank 1063.

[0034] The water level control unit 106 specifically includes a first motor 1061, a second motor 1062, and a liquid level regulating tank 1063. For example, the liquid level regulating tank 1063 can be rectangular, but the specific shape can be selected according to actual design requirements; this embodiment of the invention does not impose a specific limitation. The first motor 1061 is connected to the annular ultrasonic transducer 103. By controlling the operating state of the first motor 1061, the depth of the annular ultrasonic transducer 103 immersed in the sound-conducting liquid 107 is adjusted. Similarly, the second motor 1062 is connected to the liquid level regulating tank 1063. By controlling the operating state of the second motor 1062, the depth of the liquid level regulating tank 1063 immersed in the sound-conducting liquid 107 is adjusted. The first motor 1061 and the second motor 1062 move in opposite directions, causing the annular ultrasonic transducer 103 to move... The direction is opposite to the movement direction of the liquid level regulating tank 1063. When the annular ultrasonic transducer 103 is in the rising state, the liquid level regulating tank 1063 is in the falling state; when the annular ultrasonic transducer 103 is in the falling state, the liquid level regulating tank 1063 is in the rising state. This ensures that the horizontal plane of the sound-conducting liquid 107 in the liquid container 105 is always kept on the imaging plane of the ultrasonic transducer, thereby ensuring the acquisition effect of the photoacoustic signal by the annular ultrasonic transducer 103, so as to achieve the full-view three-dimensional lipid photoacoustic imaging effect.

[0035] Optionally, the first motor 1061 and the second motor 1062 start synchronously.

[0036] Specifically, by presetting the operating parameters of the first motor 1061 and the second motor 1062 in the control unit 104, the operating parameters may include running acceleration, speed, initial speed, and speed unit. This ensures that the first motor 1061 and the second motor 1062 start simultaneously, thereby ensuring the synchronous start of the first motor 1061 and the second motor 1062, thus ensuring the control effect of the liquid level of the sound-conducting liquid. This ensures that the liquid level is always maintained on the imaging surface of the annular ultrasonic transducer 103, reducing the absorption of the laser beam by the sound-conducting liquid 107, ensuring the laser efficiency of the photoacoustic signal, and thus ensuring the subsequent three-dimensional lipid photoacoustic imaging effect of the target 10 to be detected.

[0037] Optionally, the cross-sectional area of ​​the liquid container 105 along the first direction X is S1, the operating speed of the first motor 1061 is V1, the cross-sectional area of ​​the liquid level regulating tank 1063 along the first direction X is S2, and the operating speed of the second motor 1062 is V2, wherein S1*V1=S2*V2; wherein the first direction X is the direction parallel to the horizontal plane along which the sound-conducting liquid 107 is located.

[0038] During the synchronous movement of the first motor 1061 and the second motor 1062, the annular ultrasonic transducer 103, driven by the first motor 1061, performs vertical scanning to acquire photoacoustic data of the target 10 at different depth sections. The liquid level regulating tank 1063, driven by the second motor 1062, moves vertically, controlling the liquid level of the sound-conducting liquid 107 by adjusting the height of the tank 1063 immersed in and floating above the liquid surface. During the movement of the first motor 1061 and the second motor 1062, their directions of operation are opposite, maintaining a constant liquid volume. The cross-sectional area of ​​the device 105 along the first direction X multiplied by the running speed of the first motor 1061 is equal to the cross-sectional area of ​​the liquid level regulating tank 1063 along the first direction X multiplied by the running speed of the second motor 1062. The first direction X can be understood as the direction of the horizontal plane where the sound-conducting liquid 107 is located, which is always parallel to the placement plane of the liquid container 105. This ensures that the liquid level of the sound-conducting liquid 107 in the liquid container 105 is always at the imaging plane of the annular ultrasonic transducer 103, thereby ensuring the accuracy of the annular ultrasonic transducer 103 in acquiring acoustic and optical signals, and thus ensuring the subsequent three-dimensional imaging effect.

[0039] Optionally, the angle between the light output direction of the N output ends of the N-fiber bundle 102 and the plane where the acoustic liquid 107 is located is θ, where 30°≤θ≤60°.

[0040] In this design, the N output ends of the N-to-N fiber are evenly distributed in a ring shape along the annular portion 1031. For example, N equals 10 to form 10 output ends. The angle θ between the light output direction of each output end and the plane where the acoustic liquid 107 is located is reasonably set. The preferred angle θ is 45°. This allows the light output direction of the N output ends of the N-to-N fiber bundle 102 to perform annular excitation on the target 10 placed in the annular portion 1031 at a downward angle of 45°. This avoids the laser beam reaching the target 10 without passing through the acoustic liquid 107, thus preventing photoacoustic signal excitation, ensuring maximum acoustic signal laser efficiency, ensuring the reception of acoustic signals by the annular ultrasonic transducer 103, and thus ensuring the three-dimensional lipid scanning imaging effect.

[0041] Optionally, the laser emission unit 101 includes a laser source, a half-wave plate, a Glan prism, and an optical fiber coupler (not shown in the figure) arranged sequentially along the optical path. The laser source emits a first laser beam, which is then passed through the half-wave plate and the Glan prism in sequence to generate a second laser beam, which is then emitted to the optical fiber coupler. The optical fiber coupler couples the second laser beam to a one-to-N optical fiber bundle 102.

[0042] The laser source can be an OPO pulsed laser. The laser element outputs a first laser beam at a repetition frequency of 20 Hz. The laser energy of the first laser beam is then adjusted by a combination of a half-wave plate and a Glan prism to form a second laser beam. The second laser beam is coupled into a split-N fiber bundle 102 via an optical fiber coupler. According to the arrangement of each output end in the split-N fiber bundle 102, the laser beam emitted from the laser source can be emitted as a ring beam to the target 10 to be detected, ensuring the ring excitation of the target 10. This enables the acquisition of three-dimensional lipid photoacoustic imaging of the target 10 from all angles, allowing for a direct view of the lipid distribution information of the target.

[0043] Optionally, the wavelength of the first laser beam is λ, where 1180≤λ≤2500nm.

[0044] The laser emission unit 101 needs to emit a first laser beam with a near-infrared wavelength to the target 10 to be detected, which can convert light energy into heat energy, causing the tissue around the target 10 to expand instantaneously and generate photoacoustic signals, thus facilitating the ultrasonic transducer to receive photoacoustic signals. Therefore, the wavelength of the first laser beam is reasonably controlled in the range of 1180-2500nm to meet the requirements of three-dimensional lipid photoacoustic imaging.

[0045] Optionally, the laser source emits a first laser beam of the same wavelength within a preset time period; or, the laser source cyclically emits first laser beams of different wavelengths within a preset time period.

[0046] In the process of scanning and imaging the target 10, the preset time can be set according to the actual usage time of the full-view three-dimensional lipid optical imaging system 100, such as... Figure 2 and Figure 3 As shown, the laser source can continuously output a first laser beam of the same wavelength for a preset time to irradiate the target 10 to be detected, thereby performing scanning imaging to obtain real-time three-dimensional lipid photoacoustic imaging images of different cross-sections of the target 10 under the same wavelength; or Figure 4 This invention provides a full-view three-dimensional lipid photoacoustic image of different cross sections when the target is a mouse and the laser beam has multiple wavelengths, as shown in the embodiment of the invention. Figure 4 As shown, the laser source can cyclically emit first laser beams of different wavelengths within a preset time to irradiate the target 10, thereby performing scanning imaging to obtain real-time three-dimensional lipid photoacoustic images of different cross-sections of the target 10 under multiple wavelengths, such as... Figure 4 As shown, the white area clearly represents the lipid distribution region of the mouse. The wavelength of the first laser beam emitted by the laser source can be set according to actual design requirements to ensure the acquisition of a three-dimensional lipid photoacoustic imaging map, thereby obtaining three-dimensional lipid distribution information and improving the accuracy of disease diagnosis, personalized treatment, and health management.

[0047] Optionally, the annular portion 1031 is provided with multiple ultrasonic transducer array elements, which are arranged in a circular array.

[0048] Multiple ultrasonic transducer array elements are arranged on one side of the annular portion 1031 of the ultrasonic transducer facing the central hollow portion 1032. The ultrasonic transducer array elements are arranged in a uniform circular array according to the distribution of the annular portion 1031, which is conducive to the reception of photoacoustic signals from all directions, thereby ensuring the subsequent three-dimensional imaging effect.

[0049] This invention also provides a full-view three-dimensional lipid optical imaging device, including the full-view three-dimensional lipid optical imaging system described in any of the above embodiments.

[0050] It should be noted that since the full-view three-dimensional lipid optical imaging device provided in this embodiment includes any of the full-view three-dimensional lipid optical imaging systems provided in the embodiments of the present invention, it has the same or corresponding beneficial effects as the full-view three-dimensional lipid optical imaging system, which will not be elaborated here.

[0051] The specific embodiments described above do not constitute a limitation on the scope of protection of this invention. Those skilled in the art should understand that various modifications, combinations, sub-combinations, and substitutions can be made according to design requirements and other factors. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of this invention should be included within the scope of protection of this invention.

Claims

1. A full-view three-dimensional lipid optical imaging system, characterized in that, include: Laser emission unit, one-to-N fiber bundle, ring ultrasonic transducer, control unit, liquid container and water level control unit; The laser emission unit's emission end is connected to the input end of the N-diode fiber bundle; the control unit is connected to the annular ultrasonic transducer and the water level control unit respectively; the liquid container contains acoustically conductive liquid; The annular ultrasonic transducer includes an annular portion and a central hollow portion. The central hollow portion is used to place the target to be detected. The N output ends of the N-branch fiber bundle are evenly distributed on the annular portion and face the central hollow portion. The laser beams emitted from the N output ends form an annular beam, wherein N≥3. The annular ultrasonic transducer and at least a portion of the target to be detected are immersed in the acoustic guiding liquid; the control unit outputs water level control information, and the water level control unit controls the imaging surface of the annular ultrasonic transducer to be flush with the horizontal plane of the acoustic guiding liquid according to the water level control information; The annular beam passes through the target to be detected to the imaging surface of the annular ultrasonic transducer and generates multiple photoacoustic signals. The annular ultrasonic transducer receives the photoacoustic signals and generates electrical signals. The control unit receives the electrical signals and performs signal processing and image reconstruction to form a three-dimensional lipid image of the target to be detected. The water level control unit includes at least a first motor, a second motor, and a liquid level regulating tank; the liquid level regulating tank is at least partially immersed in the sound-conducting liquid; The control unit is connected to the first motor and the second motor respectively. The first motor is connected to the annular ultrasonic transducer and is used to control the lifting and lowering state of the annular ultrasonic transducer. The second motor is connected to the liquid level regulating tank and is used to control the lifting and lowering state of the liquid level regulating tank. The moving direction of the annular ultrasonic transducer is opposite to the moving direction of the liquid level regulating tank.

2. The full-view three-dimensional lipid optical imaging system according to claim 1, characterized in that, The first motor and the second motor start synchronously.

3. The full-view three-dimensional lipid optical imaging system according to claim 1, characterized in that, The cross-sectional area of ​​the liquid container along the first direction is S1, the operating speed of the first motor is V1, the cross-sectional area of ​​the liquid level regulating tank along the first direction is S2, and the operating speed of the second motor is V2, wherein S1*V1=S2*V2. Wherein, the first direction is a direction parallel to the horizontal plane along which the sound-conducting liquid is located.

4. The full-view three-dimensional lipid optical imaging system according to claim 1, characterized in that, The angle between the light output directions of the N output ends of the N-branch optical fiber and the plane containing the acoustic liquid is θ, where 30°≤θ≤60°.

5. The full-view three-dimensional lipid optical imaging system according to claim 1, characterized in that, The laser emission unit includes a laser source, a half-wave plate, a Glan prism, and an optical fiber coupler arranged sequentially along the optical path. The laser source emits a first laser beam, which is then passed through the half-wave plate and the Glan prism to generate a second laser beam that is emitted to the optical fiber coupler. The optical fiber coupler couples the second laser beam to the one-to-N fiber bundle.

6. The full-view three-dimensional lipid optical imaging system according to claim 5, characterized in that, The wavelength of the first laser beam is λ, where 1180≤λ≤2500nm.

7. The full-view three-dimensional lipid optical imaging system according to claim 5, characterized in that, The laser source emits the first laser beam of the same wavelength within a preset time period; or, the laser source cyclically emits the first laser beam of different wavelengths within a preset time period.

8. The full-view three-dimensional lipid optical imaging system according to claim 1, characterized in that, The annular portion is provided with multiple ultrasonic transducer array elements, which are arranged in a circular array.

9. A three-dimensional lipid optical imaging device with a full-view perspective, characterized in that, The system includes the full-view three-dimensional lipid optical imaging system according to any one of claims 1-8.

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