A spray-type liquid dressing and a preparation method thereof

Abstract

The invention provides a kind of spray-type liquid dressing and preparation method thereof, belong to the field of medical devices. The spray-type liquid dressing of the present invention includes xanthan gum, hypromellose, sugar source, sodium chloride, L-cysteine ​​and water, is a kind of polymer liquid dressing, the mechanism of action is to chelate Ca2+ by xanthan gum, hypromellose, sugar source, form hydrogen bonds with mucin and mucopolysaccharide, improve stability, no precipitation occurs, and at the same time, the SH in the L-cysteine ​​molecule can react with the ~S-S-bond of mucin in mucus to interrupt these links, change the mucus spatial structure, reduce the viscosity of mucus, so that mucus becomes thinner, so that it is easier to be discharged. And competitively bind with glycopeptide, depolymerize mucin-mucopolysaccharide macromolecular complex, form mucin loose structure, fully humidify and reduce the viscosity of mucus, and then improve its fluidity, prompt mucus to be more easily discharged from the airway, so as to achieve humidification mucus, and achieve better therapeutic effect.

Description

Technical Field

[0001] In particular, it relates to a spray-type liquid dressing and a preparation method thereof. Background Art

[0002] The respiratory tract mainly includes the human nasopharynx, trachea, bronchi and lungs. These parts all have mucosa, which has a certain filtering and controlling function. It can retain harmful substances and protect the organs of the body from damage by external harmful substances. When the mucosa in different parts of the respiratory tract is damaged, it will show a variety of symptoms, such as the shedding of respiratory mucosa, and the destruction and damage of respiratory mucosal cilia. If the respiratory mucosa is repeatedly damaged, it can cause chronic airway inflammatory diseases. In the current medical treatment process, excessive emphasis is placed on the treatment of inflammation, while ignoring the harm caused by the damage of mucosal cilia function, which will lead to high secretion of airway mucus. High secretion of airway mucosa can lead to airway obstruction, and then gas exchange dysfunction, which significantly reduces the patient's lung function and quality of life. It is an important factor affecting the progression of chronic airway inflammatory diseases.

[0003] The initial symptoms of respiratory tract damage are throat pain, redness, swelling, and cough. In the middle stage, trachea and bronchitis appear. In the late stage, there will be symptoms of coughing up sputum and even coughing up blood. However, the treatment methods used by current medical technology are generally ineffective. Summary of the invention

[0004] The purpose of the present invention is to provide a spray-type liquid dressing and a preparation method thereof. The spray-type liquid dressing provided by the present invention has a relatively good therapeutic effect in the clinical manifestations of respiratory diseases.

[0005] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions: The present invention provides a spray-type liquid dressing, which is an aqueous solution, wherein the solute in the aqueous solution comprises the following components: Xanthan gum 0.2wt%, hydroxypropyl methylcellulose 0.05-0.2wt%, sugar source 2.0-6.0wt%, sodium chloride 0.9wt%, L-cysteine ​​0.1wt%, sodium bicarbonate is used to adjust the pH value, the pH value of the sprayable liquid dressing is 6.5-7.5, and the sugar source includes brown algae polysaccharide and / or G-type brown algae oligosaccharide.

[0006] Preferably, the mass percentage of the sugar source in the aqueous solution is 6.0%, and the mass percentage of hydroxypropyl methylcellulose is 0.05%.

[0007] The present invention also provides a method for preparing the spray-type liquid dressing described in the above technical solution, comprising the following steps: Provide sodium chloride solution and sodium bicarbonate solution; The sodium chloride solution, hydroxypropyl methylcellulose and xanthan gum are mixed and swelled to obtain a swelling material; The swelling material, sugar source and L-cysteine ​​solution are mixed, sodium bicarbonate is added to adjust the pH, and then filtering and sterilizing the filtrate in sequence to obtain the sprayable liquid dressing.

[0008] Preferably, the mass fraction of the sodium bicarbonate solution is 5%.

[0009] Preferably, the sterilization temperature is 121° C. and the time is 12 min.

[0010] The present invention provides a sprayable liquid dressing, which is an aqueous solution. The solute in the aqueous solution comprises the following components: 0.2wt% of xanthan gum, 0.05-0.2wt% of hydroxypropyl methylcellulose, 2.0-6.0wt% of a sugar source, 0.9wt% of sodium chloride, 0.1wt% of L-cysteine, and sodium bicarbonate is used to adjust the pH value. The pH value of the sprayable liquid dressing is 6.5-7.5. The sugar source comprises brown algae polysaccharide and / or G-type brown algae oligosaccharide.

[0011] Compared with the prior art, the present invention has the following beneficial effects: The sprayable liquid dressing of the present invention comprises xanthan gum, hydroxypropyl methylcellulose, sugar source, sodium chloride, L-cysteine ​​and water, is a polymer liquid dressing, and the mechanism of action is to chelate Ca2+ through xanthan gum, hydroxypropyl methylcellulose and sugar source, form hydrogen bonds with mucin and mucopolysaccharide, improve stability, and no precipitation occurs. At the same time, the -SH in the L-cysteine ​​molecule can react with the ~SS-bond of mucin in mucus to interrupt these links, change the mucus spatial structure, reduce the viscosity of mucus, thereby making the mucus thinner and easier to be discharged. And competitively bind with glycopeptide, depolymerize mucin-mucopolysaccharide macromolecular complex, form mucin loose structure, fully humidify and reduce the viscosity of mucus, and then improve its fluidity, prompt mucus to be easier to discharge from the airway, thereby achieving humidified mucus, and achieving better therapeutic effect. And xanthan gum, hydroxypropyl methylcellulose and sodium chloride are used, and the pH value is adjusted in combination with sodium bicarbonate, so as to avoid the decomposition and mutation of the sugar source, thereby improving the storage stability of the sprayable liquid dressing.

[0012] The present invention also provides a method for preparing the spray-type liquid dressing described in the above technical solution. The preparation method of the present invention is simple to operate and suitable for industrial production. DETAILED DESCRIPTION

[0013] The present invention provides a spray-type liquid dressing, which is an aqueous solution, wherein the solute in the aqueous solution comprises the following components: Xanthan gum 0.2wt%, hydroxypropyl methylcellulose 0.05-0.2wt%, sugar source 2.0-6.0wt%, sodium chloride 0.9wt%, L-cysteine ​​0.1wt%, sodium bicarbonate is used to adjust the pH value, the pH value of the sprayable liquid dressing is 6.5-7.5, and the sugar source includes brown algae polysaccharide and / or G-type brown algae oligosaccharide.

[0014] In the present invention, unless otherwise specified, the raw materials used are all commercially available products in the art.

[0015] In the present invention, the mass percentage of the sugar source in the aqueous solution is 2.0%, and the mass percentage of the hydroxypropyl methylcellulose is 0.2%.

[0016] In the present invention, the mass percentage of the sugar source in the aqueous solution is 6.0%, and the mass percentage of hydroxypropyl methylcellulose is 0.05%.

[0017] The present invention also provides a method for preparing the spray-type liquid dressing described in the above technical solution, comprising the following steps: Provide sodium chloride solution and sodium bicarbonate solution; The sodium chloride solution, hydroxypropyl methylcellulose and xanthan gum are mixed and swelled to obtain a swelling material; The swelling material, sugar source and L-cysteine ​​solution are mixed, sodium bicarbonate is added to adjust the pH, and then filtering and sterilizing the filtrate in sequence to obtain the sprayable liquid dressing.

[0018] In the present invention, the mass fraction of the sodium chloride solution is preferably 0.9%.

[0019] In the present invention, the mass fraction of the sodium bicarbonate solution is preferably 5%.

[0020] In the present invention, the swelling time is preferably 4 to 5 hours, and after the swelling, the mixture is preferably stirred and dispersed for 1 to 2 hours to ensure uniform stirring and no particles.

[0021] In the present invention, the temperature for sterilizing the filtrate is preferably 121° C., and the time is preferably 12 minutes.

[0022] In the present invention, after the filtrate is sterilized, it is preferred that the filtrate is cooled and packaged in sequence. The present invention has no particular limitation on the specific methods of cooling and packaging, and methods familiar to those skilled in the art may be used.

[0023] The present invention also provides the use of the spray-type liquid dressing described in the above technical solution or the spray-type liquid dressing prepared by the preparation method described in the above technical solution in postoperative respiratory tract care.

[0024] In the present invention, the postoperative respiratory tract care preferably includes postoperative respiratory tract care for laryngeal spasm, sore throat, laryngeal edema, laryngeal ulcer, granuloma and vocal cord paralysis.

[0025] In the present invention, during the application, the sprayable liquid dressing is preferably used in the form of an aerosol or a spray.

[0026] In order to further illustrate the present invention, the sprayable liquid dressing and the preparation method thereof provided by the present invention are described in detail below in combination with examples, but they should not be construed as limiting the protection scope of the present invention. Example

[0027] Spray-on liquid dressing formulations 0.2g xanthan gum, 2g hydroxypropyl methylcellulose, 20g fucoidan, 9g sodium chloride, 1g L-cysteine, add purified water to 1000mL, and adjust the pH value of the spray liquid dressing to 6.5-7.5 with 5% sodium bicarbonate.

[0028] The preparation method is as follows: First, prepare a 0.9wt% sodium chloride solution with purified water, then slowly add the formulated amount of hydroxypropyl methylcellulose powder and xanthan gum powder, let it stand for 4 hours, wait for it to fully swell, then stir and disperse for 2 hours, then add the formulated amount of brown algae polysaccharide powder, stir to dissolve it, then add the formulated amount of L-cysteine, and then use 5wt% sodium bicarbonate solution to adjust the pH to 6.5-7.5, then filter, fill, roll cover, and then sterilize at 121°C for 12 minutes, take out and cool, and package to obtain a finished spray liquid dressing.

[0029] The sprayable liquid dressing prepared in this example had no precipitation after being placed for 14 days, and was subjected to type inspection. Example

[0030] Spray-on liquid dressing formulations 0.2g xanthan gum, 0.5g hydroxypropyl methylcellulose, 60g fucoidan, 9g sodium chloride, 1g L-cysteine, add purified water to 1000mL, and adjust the pH value of the spray liquid dressing to 6.5-7.5 with the amount of sodium bicarbonate.

[0031] The preparation method is the same as that in Example 1.

[0032] Type inspection was performed on Example 1 and Example 2. The appearance was visually inspected, the pH was tested according to the pH value determination method in the general rules (0631) of the Chinese Pharmacopoeia 2020 Edition Volume IV, the heavy metals were tested according to the heavy metal detection method in the general rules (0821) of the Chinese Pharmacopoeia 2020 Edition Volume IV, the dynamic viscosity was tested according to the third method of the rotational viscometer determination method in the general rules (0633) of the Chinese Pharmacopoeia 2020 Edition Volume IV, and the sterility was tested according to the sterility inspection method in the general rules (1101) of the Chinese Pharmacopoeia 2020 Edition Volume IV.

[0033] The inspection results of Example 1 and Example 2 are shown in Table 1.

[0034] Table 1

[0035] The invention improves the stability and prevents precipitation by adding xanthan gum, hydroxypropyl methylcellulose, fucoidan, L-cysteine, sodium chloride and water.

[0036] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be regarded as the protection scope of the present invention.

Claims

1. A spray-type liquid dressing, characterized in that: It is an aqueous solution, and the solute in the aqueous solution includes the following components: Xanthan gum 0.2wt%, hydroxypropyl methylcellulose 0.05-0.2wt%, sugar source 2.0-6.0wt%, sodium chloride 0.9wt%, L-cysteine ​​0.1wt%, sodium bicarbonate is used to adjust the pH value, the pH value of the atomized liquid dressing is 6.5-7.5, and the sugar source includes brown algae polysaccharide and / or G-type brown algae oligosaccharide.

2. The atomized liquid dressing according to claim 1, characterized in that: The mass percentage of the sugar source in the aqueous solution is 2.0%, and the mass percentage of the hydroxypropyl methylcellulose is 0.2%.

3. The atomized liquid dressing according to claim 1, characterized in that: The mass percentage of the sugar source in the aqueous solution is 6.0%, and the mass percentage of the hydroxypropyl methylcellulose is 0.05%.

4. The method for preparing the sprayable liquid dressing according to any one of claims 1 to 3, characterized in that: The following steps are involved: Provide sodium chloride solution; The sodium chloride solution, hydroxypropyl methylcellulose and xanthan gum are mixed and swelled to obtain a swelling material; The swelling material, sugar source and L-cysteine ​​solution are mixed, and then filtered and the filtrate is sterilized in sequence to obtain the sprayable liquid dressing.

5. The preparation method according to claim 4, characterized in that: The mass fraction of the sodium bicarbonate solution is 5%.

6. The preparation method according to claim 4, characterized in that: The sterilization temperature is 121° C. and the time is 12 minutes.

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