Ultrasonic cavitation dose correction method, ultrasonic cavitation dose monitoring method, ultrasonic cavitation dose correction device, ultrasonic cavitation dose monitoring device and computer equipment

Abstract

The invention relates to an ultrasonic cavitation dose correction method, an ultrasonic cavitation dose monitoring method, an ultrasonic cavitation dose correction device, ultrasonic cavitation dose monitoring equipment, a readable storage medium and a program product, relates to the technical field of medicine, and can improve the monitoring accuracy of an ultrasonic cavitation effect process. The ultrasonic cavitation dose correction method comprises the following steps: acquiring an extracranial cavitation signal acquired by an extracranial cavitation signal receiver and an intracranial cavitation signal acquired by an intracranial cavitation signal receiver; determining a first sub-cavitation dose corresponding to each frequency band of the intracranial cavitation signal, and determining cavitation dose correction information corresponding to each of a plurality of frequency bands according to the first sub-cavitation doses corresponding to each of the plurality of frequency bands; and determining second sub-cavitation doses, corresponding to the multiple frequency bands, of the extra-cranial cavitation signal, performing cavitation dose correction according to the second sub-cavitation doses corresponding to the multiple frequency bands and cavitation dose correction information corresponding to the multiple frequency bands, and obtaining an extra-cranial corrected total cavitation dose according to a correction result.

Description

Technical Field

[0001] The present application relates to the field of medical technology, and in particular to an ultrasonic cavitation dose correction method, an ultrasonic cavitation dose monitoring method, an apparatus, a computer device, a computer-readable storage medium, and a computer program product. Background Art

[0002] In the treatment of neurological and psychiatric diseases, transcranial focused ultrasound has gradually become a research hotspot and is applied in the process of brain focused ultrasound treatment because of its high spatial resolution and ability to non-invasively achieve neural regulation of deep brain tissue without affecting surface tissue.

[0003] In order to monitor the ultrasonic cavitation treatment process of the skull, the related technology mainly uses magnetic resonance imaging or ultrasonic imaging. However, the inventors found in practice that the imaging results of the above methods cannot reflect the treatment situation in time, and there is a situation where the monitoring results are inaccurate. Summary of the invention

[0004] Based on this, it is necessary to provide an ultrasonic cavitation dose correction method, an ultrasonic cavitation dose monitoring method, an apparatus, a computer device, a computer-readable storage medium and a computer program product to address the above technical problems.

[0005] In a first aspect, the present application provides an ultrasonic cavitation dose correction method, comprising:

[0006] Acquire an extracranial cavitation signal acquired by an extracranial cavitation signal receiver and an intracranial cavitation signal acquired by an intracranial cavitation signal receiver; the extracranial cavitation signal and the intracranial cavitation signal are acquired when a therapeutic ultrasound transducer emits ultrasound to cavitation nuclei in a skull skeleton;

[0007] Determine a first sub-cavitation dose corresponding to each frequency band of the intracranial cavitation signal, and determine cavitation dose correction information corresponding to each of the multiple frequency bands according to the first sub-cavitation doses corresponding to each of the multiple frequency bands;

[0008] Determine the second sub-cavitation doses corresponding to the extracranial cavitation signals in each of the multiple frequency bands, perform cavitation dose correction according to the second sub-cavitation doses corresponding to the multiple frequency bands and the cavitation dose correction information corresponding to the multiple frequency bands, and obtain the extracranial corrected total cavitation dose according to the correction result.

[0009] In one embodiment, determining the cavitation dose correction information corresponding to each of the multiple frequency bands according to the first sub-cavitation doses corresponding to each of the multiple frequency bands includes:

[0010] Normalizing the first sub-cavitation doses corresponding to each of the multiple frequency bands to obtain the normalized first sub-cavitation doses corresponding to each of the multiple frequency bands;

[0011] Obtaining correction weights corresponding to the multiple frequency bands respectively according to the normalized first sub-cavitation doses corresponding to the multiple frequency bands respectively;

[0012] According to the correction weights corresponding to the multiple frequency bands, the cavitation dose correction information corresponding to the multiple frequency bands is obtained.

[0013] In one embodiment, the cavitation dose correction is performed according to the second sub-cavitation doses corresponding to the multiple frequency bands and the cavitation dose correction information corresponding to the multiple frequency bands, and the extracranial corrected total cavitation dose is obtained according to the correction result, including:

[0014] For each frequency band of the multiple frequency bands, obtain the product of the second sub-cavitation dose of the frequency band and the correction weight corresponding to the frequency band, and determine the third sub-cavitation dose obtained after the frequency band is corrected;

[0015] The extracranial corrected total cavitation dose is obtained according to the summation result of the third sub-cavitation doses corresponding to each of the multiple frequency bands.

[0016] In one of the embodiments, the intracranial cavitation signal includes multiple groups of intracranial cavitation signals collected by multiple intracranial cavitation signal receivers respectively;

[0017] The determining of cavitation dose correction information corresponding to each of the plurality of frequency bands according to the first sub-cavitation doses corresponding to each of the plurality of frequency bands includes:

[0018] For each group of intracranial cavitation signals in the multiple groups of intracranial cavitation signals, determining cavitation dose correction information of the intracranial cavitation signals in the groups corresponding to the multiple frequency bands according to the first sub-cavitation doses corresponding to the intracranial cavitation signals in each frequency band;

[0019] For each frequency band in the multiple frequency bands, statistical processing is performed on the cavitation dose correction information in each of the groups in the frequency band, and the cavitation dose correction information corresponding to the frequency band is obtained according to the statistical result.

[0020] In one of the embodiments, the extracranial cavitation signal includes a plurality of groups of extracranial cavitation signals collected by a plurality of extracranial cavitation signal receivers respectively;

[0021] The step of performing cavitation dose correction according to the second sub-cavitation doses corresponding to the multiple frequency bands and the cavitation dose correction information corresponding to the multiple frequency bands, and obtaining the extracranial corrected total cavitation dose according to the correction result, comprises:

[0022] For each group of extracranial cavitation signals in the multiple groups of extracranial cavitation signals, according to the second sub-cavitation doses corresponding to the extracranial cavitation signals in the multiple frequency bands and the cavitation dose correction information corresponding to the multiple frequency bands, obtaining the extracranial corrected total cavitation dose in the group;

[0023] The extracranial corrected total cavitation dose in each of the groups is statistically processed, and the extracranial corrected total cavitation dose is obtained according to the statistical results.

[0024] In one embodiment, after the step of correcting the total extracranial cavitation dose according to the second sub-cavitation doses corresponding to the multiple frequency bands and the cavitation dose correction information corresponding to the multiple frequency bands to obtain the corrected total extracranial cavitation dose, the method further includes:

[0025] The output energy of the therapeutic ultrasound transducer when emitting ultrasound is adjusted, and a plurality of extracranial corrected total cavitation doses corresponding to each of the output energies are determined.

[0026] In a second aspect, the present application also provides an ultrasonic cavitation dose monitoring method, comprising:

[0027] Determining output energy information corresponding to a therapeutic ultrasonic transducer that transmits ultrasound to cavitation nuclei in the skull when transmitting ultrasound; the output energy information represents the output energy size of the therapeutic ultrasonic transducer when transmitting ultrasound;

[0028] Obtaining a predetermined cavitation dose correspondence relationship; the cavitation dose correspondence relationship includes extracranial corrected total cavitation dose information corresponding to each output energy information; the extracranial corrected total cavitation dose information is obtained according to the ultrasonic cavitation dose correction method as described in any one of the above items;

[0029] Determining matched extracranial corrected total cavitation dose information according to the output energy information corresponding to the therapeutic ultrasound transducer when emitting ultrasound and the cavitation dose correspondence relationship;

[0030] The ultrasonic cavitation dose monitoring result of the therapeutic ultrasonic transducer is determined according to the matched extracranial corrected total cavitation dose information.

[0031] In a third aspect, the present application also provides an ultrasonic cavitation dose correction device, comprising:

[0032] A cavitation signal receiving module, used to obtain an extracranial cavitation signal collected by an extracranial cavitation signal receiver and an intracranial cavitation signal collected by an intracranial cavitation signal receiver; the extracranial cavitation signal and the intracranial cavitation signal are collected when a therapeutic ultrasound transducer emits ultrasound to cavitation nuclei in the skull skeleton;

[0033] A correction information acquisition module, used to determine the first sub-cavitation dose corresponding to each frequency band of the intracranial cavitation signal, and determine the cavitation dose correction information corresponding to each of the multiple frequency bands according to the first sub-cavitation doses corresponding to each of the multiple frequency bands;

[0034] The correction module is used to determine the second sub-cavitation dose corresponding to each of the multiple frequency bands of the extracranial cavitation signal, perform cavitation dose correction according to the second sub-cavitation dose corresponding to each of the multiple frequency bands and the cavitation dose correction information corresponding to each of the multiple frequency bands, and obtain the extracranial corrected total cavitation dose according to the correction result.

[0035] In a fourth aspect, the present application also provides an ultrasonic cavitation dose monitoring device, comprising:

[0036] An output energy determination module, used to determine the output energy information corresponding to the therapeutic ultrasonic transducer that transmits ultrasound to the cavitation nuclei in the skull when transmitting ultrasound; the output energy information represents the output energy size of the therapeutic ultrasonic transducer when transmitting ultrasound;

[0037] A correspondence acquisition module, used for acquiring a predetermined cavitation dose correspondence; the cavitation dose correspondence includes extracranial corrected total cavitation dose information corresponding to each output energy information; the extracranial corrected total cavitation dose information is obtained according to the ultrasonic cavitation dose correction method as described in any one of the above items;

[0038] A matching module, used to determine the matched extracranial corrected total cavitation dose information according to the output energy information corresponding to the therapeutic ultrasound transducer when emitting ultrasound and the cavitation dose correspondence;

[0039] The monitoring result acquisition module is used to determine the ultrasonic cavitation dose monitoring result of the therapeutic ultrasonic transducer according to the matched extracranial corrected total cavitation dose information.

[0040] In a fifth aspect, the present application also provides a computer device, comprising a memory and a processor, wherein the memory stores a computer program, and when the processor executes the computer program, the steps of the ultrasonic cavitation dose correction method or the steps of the ultrasonic cavitation dose monitoring method described in any one of the above items are implemented.

[0041] In a sixth aspect, the present application further provides a computer-readable storage medium having a computer program stored thereon, wherein when the computer program is executed by a processor, the steps of the ultrasonic cavitation dose correction method or the steps of the ultrasonic cavitation dose monitoring method described in any one of the above items are implemented.

[0042] In a seventh aspect, the present application also provides a computer program product, including a computer program, which, when executed by a processor, implements the steps of any of the above-mentioned ultrasonic cavitation dose correction methods or the steps of the above-mentioned ultrasonic cavitation dose monitoring methods.

[0043] The above-mentioned ultrasonic cavitation dose correction method, ultrasonic cavitation dose monitoring method, device, computer equipment, computer-readable storage medium and computer program product can obtain extracranial cavitation signals collected by extracranial cavitation signal receivers and intracranial cavitation signals collected by intracranial cavitation signal receivers, wherein the extracranial cavitation signals and intracranial cavitation signals are collected when the therapeutic ultrasonic transducer emits ultrasound to the cavitation nuclei in the skull skeleton; then the first sub-cavitation dose corresponding to the intracranial cavitation signal in each frequency band can be determined, and the cavitation dose correction information corresponding to each of the multiple frequency bands can be determined according to the first sub-cavitation doses corresponding to each of the multiple frequency bands, and then the second sub-cavitation dose corresponding to each of the multiple frequency bands of the extracranial cavitation signal can be determined, and the cavitation dose correction information corresponding to each of the multiple frequency bands can be used to perform cavitation dose correction, and the extracranial corrected total cavitation dose can be obtained according to the correction results. In the embodiments of the present application, on the one hand, the cavitation signal generated by the cavitation nucleus is obtained through the cavitation signal receiver, thereby realizing the monitoring of the cavitation effect in transcranial focused ultrasound therapy; on the other hand, the cavitation dose correction information is determined according to the first sub-cavitation doses corresponding to each of the multiple frequency bands, and then the second sub-cavitation doses corresponding to each of the multiple frequency bands of the extracranial cavitation signal are corrected. The in vivo cavitation measurement results of the intracranial cavitation signal receiver can be used as the gold standard to make different targeted corrections to the cavitation doses of different frequency bands outside the cranium, effectively compensating for the different degrees of distortion caused by the skull to different frequency bands in the therapeutic ultrasound, correcting the error caused by the energy attenuation of ultrasound passing through the skull, and improving the accuracy of cavitation effect monitoring. BRIEF DESCRIPTION OF THE DRAWINGS

[0044] In order to more clearly illustrate the technical solutions in the embodiments of the present application or related technologies, the drawings required for use in the embodiments of the present application or related technical descriptions will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0045] Figure 1 is a schematic flow chart of an ultrasonic cavitation dose correction method in one embodiment;

[0046] Figure 2 is a schematic diagram of an ultrasonic cavitation dose correction system in one embodiment;

[0047] Figure 3A schematic flow chart of a step of obtaining cavitation dose correction information in one embodiment;

[0048] Figure 4 is a schematic flow chart of an ultrasonic cavitation dose monitoring method in one embodiment;

[0049] Figure 5 is a structural block diagram of an ultrasonic cavitation dose correction device in one embodiment;

[0050] Figure 6 is a structural block diagram of an ultrasonic cavitation dose monitoring device in one embodiment;

[0051] Figure 7 is an internal structure diagram of a computer device in one embodiment;

[0052] Figure 8 The figure is a diagram of the internal structure of another computer device in one embodiment. DETAILED DESCRIPTION

[0053] In order to make the purpose, technical solution and advantages of the present application more clearly understood, the present application is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application.

[0054] In order to enable those skilled in the art to better understand the embodiments of the present application, the relevant technologies are first introduced below.

[0055] Neuromodulation technologies such as transcranial direct current stimulation, transcranial magnetic stimulation, and deep brain stimulation have been widely used in the treatment of various neurological / psychiatric diseases (such as Parkinson's disease, epilepsy, and depression). However, transcranial direct current stimulation and transcranial magnetic stimulation have shallow depth of action, low spatial resolution, and a focal diameter of centimeters. They cannot target deeper structures without affecting more proximal tissues; deep brain stimulation is invasive and requires complex neurosurgery to implant electrodes. Compared with the above-mentioned neuromodulation technologies, transcranial focused ultrasound can achieve millimeter-level spatial resolution after calibration, and does not affect surface tissues. It can non-invasively achieve neuromodulation of deep brain tissues and has gradually become a research hotspot.

[0056] The biological mechanism of ultrasound therapy is divided into thermal effect and non-thermal effect. The non-thermal effect mainly includes cavitation effect and radiation force. Among them, the cavitation effect refers to the dynamic process of expansion, contraction and collapse of the cavitation nucleus in the medium under the action of some external physical fields (such as ultrasound field, laser field, microwave field). Steady-state cavitation is the main mechanism to promote the opening of the blood-brain barrier. It can mechanically act on the brain capillaries to separate the endothelial cells that constitute the blood-brain barrier, thereby facilitating the opening of the blood-brain barrier. In addition, the cavitation effect has been confirmed to be the main mechanism of ultrasonic thrombolysis. The cavitation effect caused by ultrasound therapy can cause the embolism to vibrate and loosen, soften the surface of the thrombus, gradually destroy the fibrin structure in the thrombus, and finally cause the thrombus to collapse and disintegrate. However, during ultrasonic cavitation therapy, the radiation force under the large ultrasonic sound pressure may damage the surrounding tissues. In the case of microbubbles, the inertial contraction force exceeding the threshold may also cause the microbubbles to collapse, thereby damaging the brain cell structure or causing unnecessary damage to the blood vessel wall. Since the cavitation effect is instantaneous and random, real-time monitoring of the cavitation dose during brain focused ultrasound therapy is the key to ensuring safe treatment.

[0057] In order to monitor the treatment process, magnetic resonance-guided transcranial focused ultrasound technology has become a new means of brain ultrasound treatment, with advantages such as high image resolution, high sensitivity to real-time changes in tissue temperature, and no interference with the focused ultrasound treatment process. However, magnetic resonance imaging mainly focuses on changes in tissue structure and is difficult to detect and monitor the transient physical process of cavitation in real time. In addition, active ultrasound imaging in traditional technology that uses focused waves as the emission method has fundamental shortcomings in brain monitoring, such as ultrasound signal attenuation, detection depth, and detection sensitivity. It can be seen that the imaging results of related technologies cannot reflect the treatment situation in a timely manner, and there are cases where the monitoring results are inaccurate.

[0058] Based on this, it is necessary to provide an ultrasonic cavitation dose correction method, an ultrasonic cavitation dose monitoring method, an apparatus, a computer device, a computer-readable storage medium and a computer program product to address the above technical problems.

[0059] In one embodiment, Figure 1 As shown, an ultrasonic cavitation dose correction method is provided. This embodiment uses the method applied to a terminal as an example for illustration. It can be understood that the method can also be applied to a server, and can also be applied to a system including a terminal and a server, and is implemented through the interaction between the terminal and the server. In this embodiment, the method includes the following steps:

[0060] S101, acquiring an extracranial cavitation signal collected by an extracranial cavitation signal receiver and an intracranial cavitation signal collected by an intracranial cavitation signal receiver; the extracranial cavitation signal and the intracranial cavitation signal are collected when a therapeutic ultrasound transducer emits ultrasound to cavitation nuclei in the skull skeleton.

[0061] Specifically, in response to the problem that magnetic resonance imaging and traditional active ultrasound imaging in related technologies cannot achieve synchronous monitoring of the brain focused ultrasound treatment process, the inventors have found in practice that by using passive cavitation monitoring, the cavitation effect process in transcranial focused ultrasound treatment can be effectively monitored, providing a more accurate feedback method for clinical applications; wherein, passive cavitation monitoring refers to the process of setting a cavitation signal receiver (such as an ultrasonic transducer that does not emit ultrasound but only receives related signals) to collect cavitation signals and monitor the ultrasonic cavitation effect based on the cavitation signals. The passive monitoring technology, taking the receiving ultrasonic transducer as an example, can make the receiving ultrasonic transducer not emit pulse signals but only receive cavitation signals generated by intracranial cavitation nuclei, so that the cavitation effect in the process of focused ultrasound can be monitored in real time, and compared with active ultrasound imaging and other technologies, it has higher detection sensitivity and optimizes the monitoring results of the ultrasonic cavitation treatment process.

[0062] However, the inventors also found that the presence of the skull will significantly attenuate the energy of ultrasonic scattering and change the spectrum of the ultrasonic signal to varying degrees, so that the cavitation signal received by the cavitation signal receiver is often not the original cavitation information generated by the cavitation nucleus of the treatment focus.

[0063] In this regard, in the embodiment of the present application, cavitation signal receivers may be respectively arranged on the outside and inside of the skull skeleton, wherein the cavitation signal receiver may be a device for receiving cavitation signals, and in one example, the cavitation signal receiver may be an ultrasonic transducer that receives ultrasonic signals but does not transmit ultrasonic signals. For the sake of distinction, the cavitation signal receiver placed on the outside of the skull skeleton is referred to as an extracranial cavitation signal receiver, and the cavitation signal receiver placed on the inside of the skull skeleton is referred to as an intracranial cavitation signal receiver.

[0064] In some embodiments, the skull skeleton is an open skull skeleton, which is a non-fully enclosed structure, and may include at least one cavity connected to the outside world, and the size of the cavity is sufficient to support at least one intracranial cavitation signal receiver to pass through; illustratively, the open skull skeleton may be a skull replica obtained by 3D printing (additive manufacturing technology), such as a human skull, an animal skull, or one or more other skull skeletons.

[0065] In one embodiment, Figure 2As shown, cavitation signal receivers can be set up on the inner and outer sides of the skull skeleton phantom 2, including an extracranial receiving ultrasonic transducer 4 (extracranial cavitation signal receiver) and an intracranial receiving ultrasonic transducer 5 (intracranial cavitation signal receiver). The inner and outer sides can be distinguished by whether the cavitation signal receiver and the cavitation core located in the skull skeleton are separated by the skull skeleton. If the cavitation signal receiver and the cavitation core are separated by the skull skeleton, the ultrasonic receiving transducer can be determined as an extracranial cavitation signal receiver. If the cavitation signal receiver and the cavitation core are not separated by the skull skeleton, that is, the cavitation signal receiver and the cavitation core are not blocked by the skull skeleton, the ultrasonic receiving transducer can be determined as an intracranial cavitation signal receiver.

[0066] In some exemplary embodiments, there may be one or more extracranial cavitation signal receivers, and there may also be one or more intracranial cavitation signal receivers, that is, cavitation signals may be collected by at least one extracranial receiving ultrasonic transducer and at least one intracranial receiving ultrasonic transducer. For example, one intracranial cavitation signal receiver and multiple extracranial cavitation signal receivers may be provided, or one extracranial cavitation signal receiver and multiple intracranial cavitation signal receivers may be provided.

[0067] In addition, in this embodiment, a therapeutic ultrasonic transducer can be set up on the outside of the skull skeleton, and a cavitation core can be placed on the inside of the skull skeleton. It can be understood that during actual ultrasonic cavitation therapy, a cavitation core can be placed at the part to be treated of the target object. Exemplarily, the cavitation core can include an ultrasonic cavitation core, such as a cavitation core obtained by one or more methods such as an ultrasonic contrast agent, a coated microbubble, a porous structure particle, a phase change nano droplet, etc.

[0068] Since the focal area of ​​the therapeutic ultrasonic transducer can gather a large amount of ultrasonic energy, it can quickly and effectively induce the cavitation effect of the cavitation nucleus, thereby improving the efficiency of ultrasonic cavitation therapy. In the actual treatment process, the position of the therapeutic ultrasonic transducer can be adjusted to make the intracranial cavitation nucleus at the focus of the therapeutic ultrasonic transducer. To this end, in some embodiments, the cavitation nucleus in the skull skeleton can be placed at the focus of the therapeutic ultrasonic transducer. Among them, the skull skeleton and the therapeutic ultrasonic transducer can be connected to each other or independent of each other. For example, when there is a connection relationship between the skull skeleton and the therapeutic ultrasonic transducer, such as a sliding connection or a snap-on connection, there is a relative position relationship between the two, the skull skeleton and the therapeutic ultrasonic transducer can be connected through an overall structure, and the relative position relationship between the skull skeleton and the therapeutic ultrasonic transducer can be adjusted by adjusting the relevant connecting parts. For another example, when the skull skeleton and the therapeutic ultrasonic transducer are independent of each other, the two are separated from each other and can be adjusted separately. For example, Figure 2As shown, a therapeutic ultrasound transducer can be placed on the top of the open skull frame, and the therapeutic ultrasound emitted by the transducer passes through the outside of the open skull frame to the focus on the inside of the open skull frame.

[0069] In this embodiment, the therapeutic ultrasound transducer, the extracranial cavitation signal receiver and the intracranial cavitation signal receiver can be pre-installed near the skull skeleton, for example, the above-mentioned devices can be placed based on the method mentioned above. It can be understood that the relative position relationship between the therapeutic ultrasound transducer, the extracranial cavitation signal receiver and the intracranial cavitation signal receiver and the skull skeleton can be set in advance, for example, the therapeutic ultrasound transducer, the extracranial cavitation signal receiver and the intracranial cavitation signal receiver can be placed according to the equipment placement rules in the actual treatment scene; it can also be planned according to the actual scene, for example, adaptive adjustment can be made according to the shape of the skull skeleton, the size of the test scene, etc.

[0070] Then, it can be determined whether the cavitation nucleus has reached the target position in the skull skeleton, for example, when a manually triggered prompt signal is received, it is determined that the target position has been reached, or it can be detected by a sensor or other means. When it is determined that the cavitation nucleus has reached the target position in the skull skeleton, the therapeutic ultrasound transducer can be started to control it to emit ultrasound to the cavitation nucleus at the target position in the skull skeleton, and then the extracranial cavitation signal receiver and the intracranial cavitation signal receiver perform signal acquisition, and the corresponding cavitation signal can be synchronously acquired and recorded; wherein, the cavitation signal can refer to the acoustic signal generated when the cavitation nucleus has a cavitation effect.

[0071] For the sake of distinction, the cavitation signal collected by the extracranial cavitation signal receiver is called the extracranial cavitation signal, and the cavitation signal collected by the intracranial cavitation signal receiver is called the intracranial cavitation signal. In some examples, the extracranial cavitation signal is a signal generated by the cavitation nucleus at the focus, which propagates from the inside of the skull skeleton to the outside of the skull skeleton and then propagates to the extracranial cavitation signal receiver; the intracranial cavitation signal is a signal generated by the cavitation nucleus at the focus and directly propagates to the intracranial cavitation signal receiver.

[0072] In some exemplary embodiments, the extracranial cavitation signal receiver and the intracranial cavitation signal receiver can be ultrasonic transducers with the same acoustic parameters, and the straight-line distances of all cavitation signal receivers relative to the focus can be kept consistent, thereby reducing the influence of other variables on the difference between the extracranial cavitation signals and the intracranial cavitation signals, and accurately correcting the ultrasonic energy attenuation and cavitation signal differences caused by the skull skeleton.

[0073] S102, determining the first sub-cavitation dose corresponding to the intracranial cavitation signal in each frequency band, and determining cavitation dose correction information corresponding to each of the multiple frequency bands according to the first sub-cavitation doses corresponding to each of the multiple frequency bands.

[0074] The frequency band can be understood as the frequency bandwidth range of each frequency component in the cavitation signal. For example, if the overall frequency band of the signal transmission source is 1 MHz, the bandwidths of multiple frequency components therein may include: the first frequency band is 0.7 to 0.8 MHz, and the second frequency band is 1.2 MHz to 1.3 MHz. Different frequency bands have different frequency bandwidth ranges.

[0075] In this step, after the intracranial cavitation signal is obtained, the intracranial cavitation signal is processed to determine the cavitation doses corresponding to the intracranial cavitation signal in multiple frequency bands, that is, the sub-cavitation doses of each frequency band, wherein the cavitation dose can characterize the level of sound wave energy corresponding to the sound wave when the cavitation effect occurs. In order to facilitate the distinction from other sub-cavitation doses, the sub-cavitation dose corresponding to the intracranial cavitation signal in each frequency band is called the first sub-cavitation dose.

[0076] In some embodiments, for the cavitation signal received by the cavitation signal receiver, the cavitation signal can be first converted to the frequency domain through Fourier transform to obtain the spectrum of the cavitation signal. ,in is the frequency; then the spectrum is divided into multiple frequency bands, each of which contains a bandwidth range within the preset range of the quartile of the harmonic frequency, and then the spectral energy of each frequency band of each group of cavitation signals (a single cavitation signal receiver obtains a cavitation signal as a group of cavitation signals) is calculated and used as the sub-cavitation dose of each frequency band:

[0077]

[0078] in, is the harmonic frequency band order calculated this time, For the The sub-cavitation dose in the harmonic frequency band, It is the center frequency of the ultrasound emitted by the therapeutic ultrasound transducer. is the frequency band bandwidth involved in the calculation, is the spectrum of the cavitation signal.

[0079] Through the above method, the first sub-cavitation dose corresponding to the intracranial cavitation signal in each frequency band can be calculated .

[0080] After obtaining the first sub-cavitation dose corresponding to each frequency band, the cavitation dose correction information corresponding to each of the multiple frequency bands can be differentially determined according to each first sub-cavitation dose, wherein the cavitation dose correction information can be information characterizing the correction method of the cavitation dose corresponding to the frequency band. In some exemplary embodiments, the cavitation dose correction information can be the weights corresponding to each of the multiple frequency bands, or can also be the cavitation dose adjustment values ​​corresponding to each of the multiple frequency bands.

[0081] S103, determine the second sub-cavitation doses corresponding to the extracranial cavitation signals in each of the multiple frequency bands, perform cavitation dose correction according to the second sub-cavitation doses corresponding to each of the multiple frequency bands and the cavitation dose correction information corresponding to each of the multiple frequency bands, and obtain the extracranial corrected total cavitation dose according to the correction result.

[0082] On the other hand, the sub-cavitation doses corresponding to the extracranial cavitation signal in multiple frequency bands can also be determined. For the sake of distinction, the sub-cavitation doses are referred to as second sub-cavitation doses. In some embodiments, the second sub-cavitation doses corresponding to the extracranial cavitation signal in multiple frequency bands can be determined by referring to the calculation formula for determining the sub-cavitation doses of the intracranial cavitation signal in each frequency band mentioned above. .

[0083] Then, for each of the multiple frequency bands, the second sub-cavitation dose corresponding to the frequency band is corrected according to the cavitation dose correction information corresponding to the frequency band to obtain the correction result of the frequency band, and then the extracranial corrected total cavitation dose is obtained according to the correction results of each frequency band.

[0084] In the above-mentioned ultrasonic cavitation dose correction method, the extracranial cavitation signal collected by the extracranial cavitation signal receiver and the intracranial cavitation signal collected by the intracranial cavitation signal receiver can be obtained, wherein the extracranial cavitation signal and the intracranial cavitation signal are collected when the therapeutic ultrasonic transducer emits ultrasound to the cavitation nuclei in the skull skeleton; then the first sub-cavitation dose corresponding to the intracranial cavitation signal in each frequency band can be determined, and the cavitation dose correction information corresponding to each of the multiple frequency bands can be determined according to the first sub-cavitation dose corresponding to each of the multiple frequency bands, and then the second sub-cavitation dose corresponding to each of the multiple frequency bands of the extracranial cavitation signal can be determined, and the cavitation dose correction information corresponding to each of the multiple frequency bands can be used to perform cavitation dose correction, and the extracranial corrected total cavitation dose can be obtained according to the correction result. In the embodiments of the present application, on the one hand, the cavitation signal generated by the cavitation nucleus is obtained through the cavitation signal receiver, thereby realizing the monitoring of the cavitation effect in transcranial focused ultrasound therapy; on the other hand, the cavitation dose correction information is determined according to the first sub-cavitation doses corresponding to each of the multiple frequency bands, and then the second sub-cavitation doses corresponding to each of the multiple frequency bands of the extracranial cavitation signal are corrected. The in vivo cavitation measurement results of the intracranial cavitation signal receiver can be used as the gold standard to make different targeted corrections to the cavitation doses of different frequency bands outside the cranium, effectively compensating for the different degrees of distortion caused by the skull to different frequency bands in the therapeutic ultrasound, correcting the error caused by the energy attenuation of ultrasound passing through the skull, and improving the accuracy of cavitation effect monitoring.

[0085] In one embodiment, Figure 3 As shown, in step S102, determining the cavitation dose correction information corresponding to each of the multiple frequency bands according to the first sub-cavitation doses corresponding to each of the multiple frequency bands may include the following steps:

[0086] S301 , normalizing the first sub-cavitation doses corresponding to the multiple frequency bands to obtain the normalized first sub-cavitation doses corresponding to the multiple frequency bands.

[0087] In a specific implementation, the first sub-cavitation doses corresponding to the multiple frequency bands can be normalized. In some examples, the first sub-cavitation doses of each frequency band of the intracranial cavitation signal can be normalized by: Normalize and obtain the value of the sub-cavitation dose in each frequency band between [0,1] , that is, the normalized first sub-cavitation dose corresponding to each frequency band:

[0088]

[0089] in, is the normalized first sub-cavitation dose in each harmonic frequency band, is the first sub-cavitation dose of all intracranial cavitation signals in this group The maximum value in All sub-cavitation doses in this group of signals The minimum value in .

[0090] S302, obtaining correction weights corresponding to the multiple frequency bands respectively according to the normalized first sub-cavitation doses corresponding to the multiple frequency bands respectively.

[0091] S303, obtaining cavitation dose correction information corresponding to each of the multiple frequency bands according to the correction weights corresponding to each of the multiple frequency bands.

[0092] After obtaining the normalized first sub-cavitation doses corresponding to each of the multiple frequency bands, for each frequency band, the normalized first sub-cavitation dose of the frequency band can be used as the correction weight corresponding to the frequency band, thereby obtaining cavitation dose correction information.

[0093] In this embodiment, correction weights corresponding to each of the multiple frequency bands are determined according to the first sub-cavitation doses corresponding to each of the multiple frequency bands, and the multiple second sub-cavitation doses are corrected as cavitation dose correction information, so that the correction amplitudes of the cavitation doses in different frequency bands outside the cranium can match the correction weights of the cavitation doses in the corresponding frequency bands inside the cranium, so that the distribution of the corrected second sub-cavitation doses in the multiple frequency bands can be closer to the actual sub-cavitation dose distributions in the multiple frequency bands inside the cranium, and more accurately compensate for the different degrees of distortion caused by the skull to different frequency bands in the therapeutic ultrasound.

[0094] Accordingly, in one embodiment, in step S103, according to the second sub-cavitation doses corresponding to the multiple frequency bands and the cavitation dose correction information corresponding to the multiple frequency bands, cavitation dose correction is performed, and according to the correction result, the extracranial corrected total cavitation dose is obtained, which may include the following steps:

[0095] For each of the multiple frequency bands, the product of the second sub-cavitation dose of the frequency band and the correction weight corresponding to the frequency band is obtained to determine the third sub-cavitation dose obtained after the frequency band is corrected; according to the sum of the third sub-cavitation doses corresponding to the multiple frequency bands, the extracranial corrected total cavitation dose is obtained.

[0096] In practical applications, for each of the multiple frequency bands, after obtaining the correction weight corresponding to the frequency band, the product of the second sub-cavitation dose and the correction weight of the same frequency band can be obtained, and the product is used as the corrected sub-cavitation dose on the frequency band. For the convenience of distinction, the sub-cavitation dose is called the third sub-cavitation dose. Then, the extracranial corrected total cavitation dose can be obtained according to the summation results of multiple third sub-cavitation doses.

[0097] In some embodiments, the extracranial corrected total cavitation dose can be determined by the following correction formula: :

[0098]

[0099] in, Corrected total extracranial cavitation dose, which can more accurately characterize the real cavitation information and reflect the real cavitation degree of the cavitation nucleus; is the correction weight of each harmonic frequency band obtained above; is the highest harmonic frequency order involved in the calculation, which is a positive integer greater than or equal to 1.

[0100] In this embodiment, by obtaining the product of the second sub-cavitation dose of the frequency band and the correction weight corresponding to the frequency band, the cavitation dose correction can be performed quickly and accurately according to the proportion of the first sub-cavitation dose of the corresponding frequency band in the brain, effectively improving the correction speed and correction accuracy of the second sub-cavitation dose.

[0101] In an exemplary embodiment, the intracranial cavitation signal includes multiple groups of intracranial cavitation signals collected by multiple intracranial cavitation signal receivers, for example, which can be set up outside the open skull frame. Accordingly, in step S102, determining the cavitation dose correction information corresponding to each of the multiple frequency bands according to the first sub-cavitation doses corresponding to each of the multiple frequency bands may include the following steps:

[0102] For each group of intracranial cavitation signals in the multiple groups of intracranial cavitation signals, the cavitation dose correction information of the intracranial cavitation signals in the groups corresponding to the multiple frequency bands is determined according to the first sub-cavitation dose corresponding to the intracranial cavitation signals in each frequency band; for each frequency band in the multiple frequency bands, the cavitation dose correction information in each group of the frequency band is statistically processed, and the cavitation dose correction information corresponding to the frequency band is obtained according to the statistical results.

[0103] In practical applications, after each intracranial cavitation signal receiver collects a corresponding group of intracranial cavitation signals, for each group of intracranial cavitation signals, the first sub-cavitation dose corresponding to the group of intracranial cavitation signals in each frequency band can be determined, and based on the first sub-cavitation dose corresponding to the group of intracranial cavitation signals in each frequency band, the cavitation dose correction information within the groups corresponding to the multiple frequency bands of the intracranial cavitation signals can be determined. The cavitation dose correction information within each group of intracranial cavitation signals can be determined according to one or more of the aforementioned embodiments. Thus, based on multiple groups of intracranial cavitation signals, multiple cavitation dose correction information sets can be obtained, each set including the cavitation dose correction information within the corresponding group, for example, According to each group of intracranial cavitation signals, A collection of cavitation dose correction information.

[0104] Since the cavitation dose correction information in multiple groups can include the cavitation dose correction information of the same frequency band, the cavitation dose correction information in each group corresponding to each frequency band in the multiple frequency bands can be determined, and then statistical processing is performed to obtain the cavitation dose correction information corresponding to the frequency band according to the statistical results. In some exemplary embodiments, the statistical processing can be to determine any one of the average value, median value, maximum value, minimum value, and weighted average value. For example, the final correction weight can be obtained by averaging:

[0105]

[0106] in, is the final correction weight of the target harmonic frequency band, where the target harmonic frequency band is one of multiple frequency bands. is the correction weight in the target harmonic frequency band obtained according to each group of intracranial cavitation signals.

[0107] In this embodiment, by obtaining cavitation dose correction information in multiple groups in each frequency band based on multiple groups of intracranial cavitation signals, and then performing statistical processing on the cavitation dose correction information in multiple groups in the same frequency band, the cavitation dose correction information corresponding to the frequency band is obtained, which can effectively reduce the errors caused by abnormalities of individual intracranial cavitation signals and improve the accuracy of the correction results.

[0108] In an exemplary embodiment, the extracranial cavitation signal includes multiple groups of extracranial cavitation signals collected by multiple extracranial cavitation signal receivers, for example, which can be set up outside the open skull frame. Correspondingly, in step S103, according to the second sub-cavitation doses corresponding to the multiple frequency bands and the cavitation dose correction information corresponding to the multiple frequency bands, the cavitation dose correction is performed, and the extracranial corrected total cavitation dose is obtained according to the correction result, which may include the following steps:

[0109] For each group of extracranial cavitation signals in the multiple groups of extracranial cavitation signals, the extracranial corrected total cavitation dose in the group is obtained according to the second sub-cavitation doses corresponding to the extracranial cavitation signals in multiple frequency bands and the cavitation dose correction information corresponding to the multiple frequency bands; the extracranial corrected total cavitation doses in each group are statistically processed, and the extracranial corrected total cavitation dose is obtained according to the statistical results.

[0110] In a specific implementation, after each extracranial cavitation signal receiver collects a corresponding group of extracranial cavitation signals, for each group of extracranial cavitation signals, according to the cavitation dose correction information corresponding to each of the multiple frequency bands, the second sub-cavitation dose corresponding to each of the group of extracranial cavitation signals in the multiple frequency bands is corrected to obtain the corrected third sub-cavitation dose in the group, and then the third sub-cavitation doses in each group are summed to obtain the extracranial corrected total cavitation dose in the group. The method for obtaining each group of extracranial corrected total cavitation dose can be determined according to one or more of the aforementioned embodiments.

[0111] Furthermore, the extracranial corrected total cavitation dose in each group can be statistically processed, and the extracranial corrected total cavitation dose can be obtained according to the statistical results. In some exemplary embodiments, the statistical processing can be to determine any one of the average value, median value, maximum value, minimum value, and weighted average value. The extracranial corrected total cavitation doses were averaged and the average value was taken as the final extracranial corrected total cavitation dose.

[0112] In this embodiment, by collecting multiple groups of extracranial cavitation signals, obtaining the extracranial corrected total cavitation doses in multiple groups based on the multiple groups of extracranial cavitation signals, and then obtaining the final extracranial corrected total cavitation dose based on the statistical results, the errors caused by abnormalities of individual extracranial cavitation signals can be effectively reduced, and the accuracy of the correction results can be improved.

[0113] In one embodiment, after step S103, the following steps may also be included:

[0114] Based on the emission of the therapeutic ultrasound transducer, the corresponding extracranial corrected total cavitation dose is updated and displayed in real time.

[0115] Specifically, the embodiments of the present application can determine the extracranial corrected total cavitation dose based on a sample of the skull skeleton. However, in the actual ultrasonic cavitation treatment process, the output energy used by the therapeutic ultrasonic transducer may change, thereby affecting the specific size of the extracranial corrected total cavitation dose. On the other hand, the specific size of the extracranial corrected total cavitation dose may also be affected by actual environmental conditions. For example, the movement of the equipment changes the distance between the therapeutic ultrasonic transducer and the cavitation nucleus, thereby changing the extracranial corrected total cavitation dose.

[0116] Based on this, in this embodiment, based on the emission of the therapeutic ultrasonic transducer in various situations, based on the steps in one or more of the above embodiments, the corresponding extracranial corrected total cavitation dose can be updated in real time and displayed. Among them, the emission of the therapeutic ultrasonic transducer can be varied in a variety of ways, for example, it can include adjusting the output energy size corresponding to the emission of the therapeutic ultrasonic transducer, adjusting the placement position of the therapeutic ultrasonic transducer, and adjusting the emission angle of the therapeutic ultrasonic transducer. By making one or more adjustments to the emission of the therapeutic ultrasonic transducer, the corresponding extracranial corrected total cavitation dose of the therapeutic ultrasonic transducer under various emissions can be determined.

[0117] Taking the adjustment of the output energy corresponding to the emission of the therapeutic ultrasonic transducer as an example for illustrative explanation, in actual application, the output energy of the therapeutic ultrasonic transducer when emitting ultrasound can be adjusted so that it emits ultrasound of different intensities to the cavitation nucleus. After each adjustment of the output energy, the process can return to execute steps S102 and S103 to obtain the extracranial corrected total cavitation dose corresponding to the current output energy. By changing the output energy of the therapeutic ultrasonic transducer when emitting ultrasound multiple times, the extracranial corrected total cavitation doses corresponding to multiple output energies can be obtained and displayed.

[0118] In this embodiment, by updating and displaying the corresponding extracranial corrected total cavitation dose in real time based on the emission of the therapeutic ultrasound transducer, the extracranial corrected total cavitation dose of the therapeutic ultrasound transducer under multiple emissions can be obtained in advance, providing a basis for quickly determining the accurate extracranial total cavitation dose in the subsequent actual ultrasound treatment process.

[0119] In one embodiment, Figure 4 As shown, an ultrasonic cavitation dose monitoring method is provided. This embodiment uses the method applied to a terminal as an example for illustration. It can be understood that the method can also be applied to a server, and can also be applied to a system including a terminal and a server, and is implemented through the interaction between the terminal and the server. In this embodiment, the method includes the following steps:

[0120] S401, determining output energy information corresponding to a therapeutic ultrasound transducer that transmits ultrasound to cavitation nuclei in the skull when transmitting ultrasound.

[0121] The output energy information represents the output energy of the therapeutic ultrasound transducer when emitting ultrasound.

[0122] In practical applications, when a therapeutic ultrasound transducer is used to transmit ultrasound to cavitation nuclei in the skull of a target object, the output energy information of the therapeutic ultrasound transducer can be determined, wherein the output energy information can be a quantitative specific value or qualitative information that qualitatively characterizes the high and low output energy.

[0123] In some exemplary embodiments, the actual acoustic energy of the therapeutic ultrasonic transducer at different voltages can be measured in advance by a hydrophone system, and then in actual applications, the corresponding acoustic energy can be found by looking up the actual voltage of the ultrasonic transducer to determine the corresponding output energy information; in other embodiments, the acoustic energy can also be measured on-site by a hydrophone system and / or an acoustic radiation force system to obtain the corresponding output energy information.

[0124] S402, obtaining a predetermined cavitation dose correspondence relationship; the cavitation dose correspondence relationship includes extracranial corrected total cavitation dose information corresponding to each output energy information.

[0125] In a specific implementation, the cavitation dose correspondence relationship can be obtained in advance, and the cavitation dose correspondence relationship can describe the corresponding extracranial corrected total cavitation dose information when the therapeutic ultrasound transducer is at different distances and / or different transducer position relationships (i.e., the position relationship between the therapeutic ultrasound transducer and the cavitation signal receiver). For example, by changing the distance between the therapeutic ultrasound transducer and the cavitation nucleus and the relative position relationship with other cavitation signal receivers in advance, the extracranial corrected total cavitation dose information under different conditions can be obtained.

[0126] Among them, the extracranial corrected total cavitation dose information can be a specific extracranial corrected total cavitation dose, or it can be a cavitation dose correction coefficient determined based on the specific extracranial corrected total cavitation dose, such as the extracranial cavitation dose correction coefficient and the intracranial cavitation dose correction coefficient. When constructing the cavitation dose correspondence relationship, each extracranial corrected total cavitation dose corresponding to the therapeutic ultrasonic transducer at each distance and / or transducer position relationship can be obtained according to the ultrasonic cavitation dose correction method of one or more of the aforementioned embodiments.

[0127] In some embodiments, during a correction process of ultrasonic cavitation dose correction, if multiple extracranial cavitation signal receivers are used, the extracranial corrected total cavitation dose corresponding to each of the multiple extracranial cavitation signal receivers can be determined, and then the extracranial corrected total cavitation doses of the multiple extracranial cavitation signal receivers are averaged or weighted summed, and the extracranial corrected total cavitation dose information at the corresponding distance and / or transducer position relationship is obtained according to the processing results, wherein, if weighted summation is performed, the weight of each extracranial cavitation signal receiver can be manually set according to actual conditions.

[0128] Furthermore, in the actual application of the therapeutic ultrasound transducer, the pre-constructed cavitation dose correspondence can be obtained.

[0129] S403, determining the matching extracranial corrected total cavitation dose information according to the output energy information corresponding to the therapeutic ultrasound transducer when emitting ultrasound and the corresponding relationship between the cavitation dose.

[0130] Furthermore, the output energy information corresponding to the therapeutic ultrasonic transducer when emitting ultrasound can be matched with the pre-constructed cavitation dose correspondence relationship to determine the extracranial corrected total cavitation dose information that matches the current output energy information. For example, the output energy information closest to the current output energy information of the therapeutic ultrasonic transducer can be determined in the cavitation dose correspondence relationship, and then the extracranial corrected total cavitation dose information corresponding to the closest output energy information is used as the matched extracranial corrected total cavitation dose.

[0131] S404, determining the ultrasonic cavitation dose monitoring result of the therapeutic ultrasonic transducer according to the matched extracranial corrected total cavitation dose information.

[0132] Furthermore, the ultrasonic cavitation dose monitoring result of the therapeutic ultrasonic transducer can be determined based on the matched corrected total extracranial cavitation dose information. In some embodiments, this method can be used to determine whether the ultrasonic cavitation dose monitoring result of the therapeutic ultrasonic transducer is accurate, which helps to prompt correction in time when an abnormality occurs.

[0133] In the above-mentioned ultrasonic cavitation dose monitoring method, the output energy information corresponding to the therapeutic ultrasonic transducer that emits ultrasound to the cavitation nuclei in the skull when emitting ultrasound can be determined, wherein the output energy information represents the output energy of the therapeutic ultrasonic transducer when emitting ultrasound; then a predetermined cavitation dose correspondence relationship can be obtained, the cavitation dose correspondence relationship includes the extracranial corrected total cavitation dose information corresponding to each output energy information, and the extracranial corrected total cavitation dose information is obtained according to the ultrasonic cavitation dose correction method in any of the aforementioned embodiments; and then, according to the output energy information corresponding to the therapeutic ultrasonic transducer when emitting ultrasound and the cavitation dose correspondence relationship, the matching extracranial corrected total cavitation dose information is determined, and according to the matching extracranial corrected total cavitation dose information, the ultrasonic cavitation dose monitoring result of the therapeutic ultrasonic transducer is determined. In this embodiment, on the one hand, the corresponding extracranial corrected total cavitation dose can be quickly matched according to the output energy information of the therapeutic ultrasound transducer, and the cavitation effect in transcranial focused ultrasound therapy can be dynamically and timely monitored through the corresponding cavitation dose size; on the other hand, since multiple extracranial corrected total cavitation doses are corrected extracranial total cavitation doses, they can effectively compensate for the different degrees of distortion caused by the skull to different frequency bands in the therapeutic ultrasound, so that the matched extracranial corrected total cavitation dose can more accurately reflect the intracranial cavitation situation and improve the accuracy of cavitation effect monitoring.

[0134] In order to enable those skilled in the art to better understand the above steps, the embodiment of the present application is illustrated below by using an example, but it should be understood that the embodiment of the present application is not limited to this.

[0135] Step 1: Figure 2 As shown, an open skull phantom 2 constructed by 3D printing and simulating the acoustic parameters of a human skull can be placed in a water tank 1. The open skull phantom 2 is a non-fully enclosed hemispherical shell structure with a spherical radius of 20-25 cm. A therapeutic ultrasonic transducer 3 is set up on the top of the spherical shell of the open skull phantom 2. The physical focal length of the therapeutic ultrasonic transducer 3 is 30 cm, and its focus is located on the inner side of the spherical shell of the open skull phantom 2. An extracranial receiving ultrasonic transducer 4 is set up on the outside of the spherical shell of the open skull phantom 2, and an intracranial receiving ultrasonic transducer 5 is set up on the inside of the spherical shell of the open skull phantom 2. The straight-line distances of the extracranial receiving ultrasonic transducer 4 and the intracranial receiving ultrasonic transducer 5 relative to the focus are consistent, both of which are 26 cm, and the acoustic parameters of the two are consistent, such as the center frequency and focal length. The extracranial receiving ultrasonic transducer 4 and the intracranial receiving ultrasonic transducer 5 form a receiving ultrasonic transducer module 7. 1 mL of a commonly used medical contrast agent microbubble solution is injected at the focus of the therapeutic ultrasonic transducer 3 as a cavitation nucleus 6.

[0136] Step 2, start the therapeutic ultrasonic transducer 3 to transmit an ultrasonic pulse with a center frequency of 1 MHz, stimulate the cavitation nucleus 6 at the focus to cavitation, and the generated cavitation signal propagates through the inner side of the spherical shell of the open skull phantom 2 to the outer side of the spherical shell, and then propagates to the extracranial receiving ultrasonic transducer 4 to be received, and is collected and recorded by the cavitation signal acquisition module 8; at the same time, the cavitation signal generated by the cavitation nucleus 6 at the focus is directly propagated to the intracranial receiving ultrasonic transducer 5 to be received, and is synchronously collected and recorded by the cavitation signal acquisition module 8.

[0137] Step 3: input all cavitation signals obtained by the cavitation signal acquisition module 8 in step 2 into the cavitation signal calculation module 9, convert the cavitation signals into the frequency domain through Fourier transform, calculate the spectra of different frequency bands in the two groups of cavitation signals respectively, and obtain the sub-cavitation doses of each frequency band in the two groups. Specifically, it includes the following steps:

[0138] 3-1. Through Fourier transform, the cavitation signal obtained in step 2 is converted to the frequency domain to obtain the frequency spectra of two sets of cavitation signals. ,in is the frequency;

[0139] 3-2, each group The spectrum is divided into frequency bands, each of which contains 1000 data points in the 0.2 MHz bandwidth range near the upper and lower quartiles of the harmonic frequency. The spectrum energy of each frequency band of each group of signals, that is, the sub-cavitation dose of each frequency band, is calculated respectively:

[0140] ,

[0141] in, is the harmonic frequency band order calculated this time, It can be a manually set value, which is related to the receiving frequency bandwidth range of the transducer. The upper limit of the value in the formula does not exceed the receiving frequency bandwidth range of the transducer; For the Sub-cavitation dose in the harmonic frequency band; The center frequency of the ultrasonic wave emitted by the therapeutic ultrasonic transducer is 1 MHz, such as the exemplary embodiment provided in this embodiment; is the frequency band bandwidth involved in the calculation, such as 0.2 MHz provided by way of example in this embodiment. In some examples, the frequency band bandwidth may be manually set according to actual conditions, and its value range may be less than or equal to f0 / 2; is the spectrum of the cavitation signal. In this embodiment, When extracting (1.25 ) 1000 data points in the frequency band are involved in the calculation of the sub-cavitation dose.

[0142] Step 4: Correct the weights of the sub-cavitation doses of each frequency band outside the skull by using the normalized results of the sub-cavitation doses of each frequency band inside the skull, obtain the correction formula for calculating the cavitation dose after correction, and apply it to calculate the cavitation dose of the extracranial cavitation signal. Specifically, it includes the following steps:

[0143] 4-1. Sub-cavitation doses of intracranial cavitation signals in each frequency band Normalize and obtain the value between [0,1] corresponding to the sub-cavitation dose in each frequency band as the correction weight;

[0144] 4-2. Calculate the corrected total extracranial cavitation dose.

[0145] Step 5: The total cavitation dose generated by the corrected therapeutic ultrasound is presented in the cavitation dose display module 10. By recording the energy output by the therapeutic ultrasound transducer 3 and the cavitation dose presented by the cavitation dose display module 10 and establishing a correlation, the corresponding cavitation dose can be evaluated in ultrasound treatment under different energy applications.

[0146] It should be understood that, although the various steps in the flowcharts involved in the above-mentioned embodiments are displayed in sequence according to the indication of the arrows, these steps are not necessarily executed in sequence according to the order indicated by the arrows. Unless there is a clear explanation in this article, the execution of these steps does not have a strict order restriction, and these steps can be executed in other orders. Moreover, at least a part of the steps in the flowcharts involved in the above-mentioned embodiments can include multiple steps or multiple stages, and these steps or stages are not necessarily executed at the same time, but can be executed at different times, and the execution order of these steps or stages is not necessarily to be carried out in sequence, but can be executed in turn or alternately with other steps or at least a part of the steps or stages in other steps.

[0147] Based on the same inventive concept, the embodiment of the present application also provides an ultrasonic cavitation dose correction device for implementing the ultrasonic cavitation dose correction method involved above. The implementation scheme for solving the problem provided by the device is similar to the implementation scheme recorded in the above method, so the specific limitations in one or more ultrasonic cavitation dose correction device embodiments provided below can refer to the limitations of the ultrasonic cavitation dose correction method above, and will not be repeated here.

[0148] In an exemplary embodiment, Figure 5 As shown, an ultrasonic cavitation dose correction device is provided, comprising:

[0149] The cavitation signal receiving module 501 is used to obtain the extracranial cavitation signal collected by the extracranial cavitation signal receiver and the intracranial cavitation signal collected by the intracranial cavitation signal receiver; the extracranial cavitation signal and the intracranial cavitation signal are collected when the therapeutic ultrasound transducer transmits ultrasound to the cavitation nuclei in the skull skeleton;

[0150] The correction information acquisition module 502 is used to determine the first sub-cavitation dose corresponding to each frequency band of the intracranial cavitation signal, and determine the cavitation dose correction information corresponding to each of the multiple frequency bands according to the first sub-cavitation doses corresponding to each of the multiple frequency bands;

[0151] The correction module 503 is used to determine the second sub-cavitation dose corresponding to each of the multiple frequency bands of the extracranial cavitation signal, perform cavitation dose correction according to the second sub-cavitation dose corresponding to each of the multiple frequency bands and the cavitation dose correction information corresponding to each of the multiple frequency bands, and obtain the extracranial corrected total cavitation dose according to the correction result.

[0152] In one embodiment, the correction information acquisition module 502 is used to:

[0153] Normalizing the first sub-cavitation doses corresponding to each of the multiple frequency bands to obtain the normalized first sub-cavitation doses corresponding to each of the multiple frequency bands;

[0154] Obtaining correction weights corresponding to the multiple frequency bands respectively according to the normalized first sub-cavitation doses corresponding to the multiple frequency bands respectively;

[0155] According to the correction weights corresponding to the multiple frequency bands, the cavitation dose correction information corresponding to the multiple frequency bands is obtained.

[0156] In one embodiment, the correction module 503 is used to:

[0157] For each frequency band of the multiple frequency bands, obtain the product of the second sub-cavitation dose of the frequency band and the correction weight corresponding to the frequency band, and determine the third sub-cavitation dose obtained after the frequency band is corrected;

[0158] The extracranial corrected total cavitation dose is obtained according to the summation result of the third sub-cavitation doses corresponding to each of the multiple frequency bands.

[0159] In one embodiment, the intracranial cavitation signal includes a plurality of groups of intracranial cavitation signals collected by a plurality of intracranial cavitation signal receivers respectively;

[0160] The correction information acquisition module 502 is used to:

[0161] For each group of intracranial cavitation signals in the multiple groups of intracranial cavitation signals, determining cavitation dose correction information of the intracranial cavitation signals in the groups corresponding to the multiple frequency bands according to the first sub-cavitation doses corresponding to the intracranial cavitation signals in each frequency band;

[0162] For each frequency band in the multiple frequency bands, statistical processing is performed on the cavitation dose correction information in each of the groups in the frequency band, and the cavitation dose correction information corresponding to the frequency band is obtained according to the statistical result.

[0163] In one embodiment, the extracranial cavitation signal includes a plurality of groups of extracranial cavitation signals respectively collected by a plurality of extracranial cavitation signal receivers;

[0164] The correction module 503 is used to:

[0165] For each group of extracranial cavitation signals in the multiple groups of extracranial cavitation signals, according to the second sub-cavitation doses corresponding to the extracranial cavitation signals in the multiple frequency bands and the cavitation dose correction information corresponding to the multiple frequency bands, obtaining the extracranial corrected total cavitation dose in the group;

[0166] The extracranial corrected total cavitation dose in each of the groups is statistically processed, and the extracranial corrected total cavitation dose is obtained according to the statistical results.

[0167] In one embodiment, after the step of correcting the total extracranial cavitation dose according to the second sub-cavitation doses corresponding to the multiple frequency bands and the cavitation dose correction information corresponding to the multiple frequency bands to obtain the corrected total extracranial cavitation dose, the method further includes:

[0168] The output energy of the therapeutic ultrasound transducer when emitting ultrasound is adjusted, and a plurality of extracranial corrected total cavitation doses corresponding to each of the output energies are determined.

[0169] Based on the same inventive concept, the embodiment of the present application also provides an ultrasonic cavitation dose monitoring device for implementing the ultrasonic cavitation dose monitoring method involved above. The implementation scheme for solving the problem provided by the device is similar to the implementation scheme recorded in the above method, so the specific limitations in one or more ultrasonic cavitation dose monitoring device embodiments provided below can refer to the limitations of the ultrasonic cavitation dose monitoring method above, and will not be repeated here.

[0170] In an exemplary embodiment, Figure 6 As shown, an ultrasonic cavitation dose monitoring device is provided, comprising:

[0171] The output energy determination module 601 is used to determine the output energy information corresponding to the therapeutic ultrasonic transducer that transmits ultrasound to the cavitation nuclei in the skull when transmitting ultrasound; the output energy information represents the output energy size of the therapeutic ultrasonic transducer when transmitting ultrasound;

[0172] The corresponding relationship acquisition module 602 is used to acquire a predetermined cavitation dose corresponding relationship; the cavitation dose corresponding relationship includes extracranial corrected total cavitation dose information corresponding to each output energy information; the extracranial corrected total cavitation dose information is obtained according to the ultrasonic cavitation dose correction method described in any of the above embodiments;

[0173] A matching module 603 is used to determine the matched extracranial corrected total cavitation dose information according to the output energy information corresponding to the therapeutic ultrasound transducer when emitting ultrasound and the cavitation dose correspondence relationship;

[0174] The monitoring result acquisition module 604 is used to determine the ultrasonic cavitation dose monitoring result of the therapeutic ultrasonic transducer according to the matched extracranial corrected total cavitation dose information.

[0175] Each module in the ultrasonic cavitation dose correction device and the ultrasonic cavitation dose monitoring device can be implemented in whole or in part by software, hardware, or a combination thereof. Each module can be embedded in or independent of a processor in a computer device in the form of hardware, or can be stored in a memory in a computer device in the form of software, so that the processor can call and execute operations corresponding to each module.

[0176] In an exemplary embodiment, a computer device is provided. The computer device may be a server, and its internal structure diagram may be as shown in FIG. Figure 7 As shown. The computer device includes a processor, a memory, an input / output interface (Input / Output, referred to as I / O) and a communication interface. The processor, the memory and the input / output interface are connected through a system bus, and the communication interface is connected to the system bus through the input / output interface. The processor of the computer device is used to provide computing and control capabilities. The memory of the computer device includes a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system, a computer program and a database. The internal memory provides an environment for the operation of the operating system and the computer program in the non-volatile storage medium. The database of the computer device is used to store cavitation signal data. The input / output interface of the computer device is used to exchange information between the processor and an external device. The communication interface of the computer device is used to communicate with an external terminal through a network connection. When the computer program is executed by the processor, an ultrasonic cavitation dose correction method or an ultrasonic cavitation dose monitoring method is implemented.

[0177] In an exemplary embodiment, a computer device is provided. The computer device may be a terminal, and its internal structure diagram may be as shown in FIG. Figure 8 As shown. The computer device includes a processor, a memory, an input / output interface, a communication interface, a display unit and an input device. The processor, the memory and the input / output interface are connected through a system bus, and the communication interface, the display unit and the input device are connected to the system bus through the input / output interface. The processor of the computer device is used to provide computing and control capabilities. The memory of the computer device includes a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system and a computer program. The internal memory provides an environment for the operation of the operating system and the computer program in the non-volatile storage medium. The input / output interface of the computer device is used to exchange information between the processor and the external device. The communication interface of the computer device is used to communicate with an external terminal in a wired or wireless manner, and the wireless manner can be realized through WIFI, a mobile cellular network, near field communication (NFC) or other technologies. When the computer program is executed by the processor, an ultrasonic cavitation dose correction method or an ultrasonic cavitation dose monitoring method is implemented. The display unit of the computer device is used to form a visually visible picture, which can be a display screen, a projection device or a virtual reality imaging device. The display screen can be a liquid crystal display screen or an electronic ink display screen, and the input device of the computer device can be a touch layer covering the display screen, or a button, trackball or touchpad set on the computer device shell, or an external keyboard, touchpad or mouse.

[0178] Those skilled in the art will understand that Figure 7 and Figure 8 The structure shown in the figure is only a block diagram of a part of the structure related to the solution of the present application, and does not constitute a limitation on the computer device to which the solution of the present application is applied. The specific computer device may include more or fewer components than those shown in the figure, or combine certain components, or have a different arrangement of components.

[0179] In one embodiment, a computer device is provided, including a memory and a processor, wherein a computer program is stored in the memory, and the processor implements the steps in the above-mentioned method embodiments when executing the computer program.

[0180] In one embodiment, a computer-readable storage medium is provided, on which a computer program is stored. When the computer program is executed by a processor, the steps in the above-mentioned method embodiments are implemented.

[0181] In one embodiment, a computer program product is provided, including a computer program, which implements the steps in the above method embodiments when executed by a processor.

[0182] It should be noted that the user information (including but not limited to user device information, user personal information, etc.) and data (including but not limited to data used for analysis, stored data, displayed data, etc.) involved in this application are all information and data authorized by the user or fully authorized by all parties, and the collection, use and processing of relevant data must comply with relevant regulations.

[0183] A person of ordinary skill in the art can understand that all or part of the processes in the above-mentioned embodiment method can be completed by instructing the relevant hardware through a computer program, and the computer program can be stored in a non-volatile computer-readable storage medium. When the computer program is executed, it can include the processes of the embodiments of the above-mentioned methods. Among them, any reference to the memory, database or other medium used in the embodiments provided in the present application can include at least one of non-volatile memory and volatile memory. Non-volatile memory can include read-only memory (ROM), magnetic tape, floppy disk, flash memory, optical memory, high-density embedded non-volatile memory, resistive random access memory (ReRAM), magnetic random access memory (MRAM), ferroelectric random access memory (FRAM), phase change memory (PCM), graphene memory, etc. Volatile memory can include random access memory (RAM) or external cache memory, etc. As an illustration and not limitation, RAM can be in various forms, such as static random access memory (SRAM) or dynamic random access memory (DRAM). The database involved in each embodiment provided in this application may include at least one of a relational database and a non-relational database. Non-relational databases may include distributed databases based on blockchains, etc., but are not limited to this. The processor involved in each embodiment provided in this application may be a general-purpose processor, a central processing unit, a graphics processor, a digital signal processor, a programmable logic device, a data processing logic device based on quantum computing, an artificial intelligence (AI) processor, etc., but are not limited to this.

[0184] The technical features of the above embodiments may be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this application.

[0185] The above-described embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the present application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the present application shall be subject to the attached claims.

Claims

1. A method for correcting ultrasonic cavitation dose, characterized in that: The method comprises: Acquire an extracranial cavitation signal acquired by an extracranial cavitation signal receiver and an intracranial cavitation signal acquired by an intracranial cavitation signal receiver; the extracranial cavitation signal and the intracranial cavitation signal are acquired when a therapeutic ultrasound transducer emits ultrasound to cavitation nuclei in a skull skeleton; Determine a first sub-cavitation dose corresponding to each frequency band of the intracranial cavitation signal, and determine cavitation dose correction information corresponding to each of the multiple frequency bands according to the first sub-cavitation doses corresponding to each of the multiple frequency bands; Determine the second sub-cavitation doses corresponding to the extracranial cavitation signals in each of the multiple frequency bands, perform cavitation dose correction according to the second sub-cavitation doses corresponding to the multiple frequency bands and the cavitation dose correction information corresponding to the multiple frequency bands, and obtain the extracranial corrected total cavitation dose according to the correction result.

2. The method according to claim 1, characterized in that The determining of cavitation dose correction information corresponding to each of the plurality of frequency bands according to the first sub-cavitation doses corresponding to each of the plurality of frequency bands includes: Normalizing the first sub-cavitation doses corresponding to each of the multiple frequency bands to obtain the normalized first sub-cavitation doses corresponding to each of the multiple frequency bands; Obtaining correction weights corresponding to the multiple frequency bands respectively according to the normalized first sub-cavitation doses corresponding to the multiple frequency bands respectively; According to the correction weights corresponding to the multiple frequency bands, the cavitation dose correction information corresponding to the multiple frequency bands is obtained.

3. The method according to claim 2, characterized in that The step of performing cavitation dose correction according to the second sub-cavitation doses corresponding to the multiple frequency bands and the cavitation dose correction information corresponding to the multiple frequency bands, and obtaining the extracranial corrected total cavitation dose according to the correction result, comprises: For each frequency band of the multiple frequency bands, obtain the product of the second sub-cavitation dose of the frequency band and the correction weight corresponding to the frequency band, and determine the third sub-cavitation dose obtained after the frequency band is corrected; The extracranial corrected total cavitation dose is obtained according to the summation result of the third sub-cavitation doses corresponding to each of the multiple frequency bands.

4. The method according to claim 1, characterized in that: The intracranial cavitation signal includes a plurality of groups of intracranial cavitation signals collected by a plurality of intracranial cavitation signal receivers; The determining of cavitation dose correction information corresponding to each of the plurality of frequency bands according to the first sub-cavitation doses corresponding to each of the plurality of frequency bands includes: For each group of intracranial cavitation signals in the multiple groups of intracranial cavitation signals, determining cavitation dose correction information of the intracranial cavitation signals in the groups corresponding to the multiple frequency bands according to the first sub-cavitation doses corresponding to the intracranial cavitation signals in each frequency band; For each frequency band in the multiple frequency bands, statistical processing is performed on the cavitation dose correction information in each of the groups in the frequency band, and the cavitation dose correction information corresponding to the frequency band is obtained according to the statistical result.

5. The method according to claim 1, characterized in that The extracranial cavitation signals include multiple groups of extracranial cavitation signals collected by multiple extracranial cavitation signal receivers; The step of performing cavitation dose correction according to the second sub-cavitation doses corresponding to the multiple frequency bands and the cavitation dose correction information corresponding to the multiple frequency bands, and obtaining the extracranial corrected total cavitation dose according to the correction result, comprises: For each group of extracranial cavitation signals in the multiple groups of extracranial cavitation signals, according to the second sub-cavitation doses corresponding to the extracranial cavitation signals in the multiple frequency bands and the cavitation dose correction information corresponding to the multiple frequency bands, obtaining the extracranial corrected total cavitation dose in the group; The extracranial corrected total cavitation dose in each of the groups is statistically processed, and the extracranial corrected total cavitation dose is obtained according to the statistical results.

6. The method according to claim 1, characterized in that After the step of correcting the total extracranial cavitation dose according to the second sub-cavitation doses corresponding to the multiple frequency bands and the cavitation dose correction information corresponding to the multiple frequency bands to obtain the corrected total extracranial cavitation dose, the method further includes: Based on the emission of the therapeutic ultrasound transducer, the corresponding extracranial corrected total cavitation dose is updated and displayed in real time.

7. An ultrasonic cavitation dose monitoring method, characterized in that: The method comprises: Determining output energy information corresponding to a therapeutic ultrasonic transducer that transmits ultrasound to cavitation nuclei in the skull when transmitting ultrasound; the output energy information represents the output energy size of the therapeutic ultrasonic transducer when transmitting ultrasound; Obtaining a predetermined cavitation dose correspondence relationship; the cavitation dose correspondence relationship includes extracranial corrected total cavitation dose information corresponding to each output energy information; the extracranial corrected total cavitation dose information is obtained according to the ultrasonic cavitation dose correction method according to any one of claims 1 to 6; Determining matched extracranial corrected total cavitation dose information according to the output energy information corresponding to the therapeutic ultrasound transducer when emitting ultrasound and the cavitation dose correspondence relationship; The ultrasonic cavitation dose monitoring result of the therapeutic ultrasonic transducer is determined according to the matched extracranial corrected total cavitation dose information.

8. An ultrasonic cavitation dose correction device, characterized in that: The device comprises: A cavitation signal receiving module, used to obtain an extracranial cavitation signal collected by an extracranial cavitation signal receiver and an intracranial cavitation signal collected by an intracranial cavitation signal receiver; the extracranial cavitation signal and the intracranial cavitation signal are collected when a therapeutic ultrasound transducer emits ultrasound to cavitation nuclei in the skull skeleton; A correction information acquisition module, used to determine the first sub-cavitation dose corresponding to each frequency band of the intracranial cavitation signal, and determine the cavitation dose correction information corresponding to each of the multiple frequency bands according to the first sub-cavitation doses corresponding to each of the multiple frequency bands; The correction module is used to determine the second sub-cavitation dose corresponding to each of the multiple frequency bands of the extracranial cavitation signal, perform cavitation dose correction according to the second sub-cavitation dose corresponding to each of the multiple frequency bands and the cavitation dose correction information corresponding to each of the multiple frequency bands, and obtain the extracranial corrected total cavitation dose according to the correction result.

9. An ultrasonic cavitation dose monitoring device, characterized in that: The device comprises: An output energy determination module, used to determine the output energy information corresponding to the therapeutic ultrasonic transducer that transmits ultrasound to the cavitation nuclei in the skull when transmitting ultrasound; the output energy information represents the output energy size of the therapeutic ultrasonic transducer when transmitting ultrasound; A correspondence acquisition module, used for acquiring a predetermined cavitation dose correspondence; the cavitation dose correspondence includes an extracranial corrected total cavitation dose corresponding to each output energy information; the extracranial corrected total cavitation dose is obtained according to the ultrasonic cavitation dose correction method according to any one of claims 1 to 6; A matching module, used for determining a matched extracranial corrected total cavitation dose according to the output energy information corresponding to the therapeutic ultrasound transducer when emitting ultrasound and the corresponding relationship of the cavitation dose; The monitoring result acquisition module is used to determine the ultrasonic cavitation dose monitoring result of the therapeutic ultrasonic transducer according to the matched extracranial corrected total cavitation dose.

10. A computer device comprising a memory and a processor, wherein the memory stores a computer program, characterized in that: When the processor executes the computer program, the steps of the ultrasonic cavitation dose correction method according to any one of claims 1 to 6 or the steps of the ultrasonic cavitation dose monitoring method according to claim 7 are implemented.

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