Degradable air bag device for preventing intestinal anastomosis leakage

Abstract

The degradable air bag device for preventing intestinal anastomosis leakage comprises a plurality of sheet-shaped air bags, the inside of the sheet-shaped air bags are communicated and mutually connected to form a tubular air inflation structure with the hollow inside and the two open ends, and an air inlet and an air outlet are formed in the tubular air inflation structure. The air inlet and the air outlet are communicated with an air inlet pipe and an air outlet pipe respectively, and a bionic adhesion surface structure is formed on the outer side face of the sheet-shaped air bag. The tubular inflation structure is inflated, expanded and expanded to form a tubular structure, the outer side of the expanded tubular inflation structure is tightly attached to the inner surface of the intestinal wall at the anastomotic stoma to form a supporting sealing structure, and the tubular inflation structure is deflated, collapsed and shrunk inwards to be removed. By means of innovative air bag design and bionic fixation, multiple sealing layers can be formed around the anastomotic stoma, it is ensured that the device cannot move in the tissue repairing process, the intestinal anastomotic stoma is effectively protected against influences of dirt in the intestinal tract, leakage of intestinal contents is prevented, and leakage of the anastomotic stoma is reduced.

Description

Technical Field

[0001] The invention relates to the technical field of medical devices, and in particular to a degradable air bag device for preventing intestinal anastomosis leakage. Background Art

[0002] In the treatment of digestive system diseases, intestinal anastomosis is a crucial operation. Various diseases such as intestinal tumors and intestinal trauma require this operation. However, intestinal anastomotic leakage is one of the common and serious complications after intestinal anastomosis, especially in colorectal surgery, with an incidence rate of 2.4-15.9%. Once it occurs, it may lead to severe infection, peritonitis, and even life-threatening. The occurrence of intestinal anastomotic leakage not only prolongs the hospitalization time, but also increases the patient's pain and medical expenses.

[0003] In order to prevent intestinal anastomotic leakage, a secondary operation of preventive ostomy is usually performed clinically. This secondary operation opens a stoma in the intestine to drain the intestinal contents into a collection bag outside the body, thereby avoiding pressure and contamination on the anastomosis. However, this method causes additional trauma to the patient and brings inconvenience in daily life because the patient needs to adapt to the use and care of the stoma bag. Therefore, a new device is urgently needed to effectively prevent intestinal anastomotic leakage, reduce the incidence of postoperative complications, and promote patient recovery. Summary of the invention

[0004] In order to solve the problem that the existing ostomy means for preventing intestinal anastomotic leakage may cause additional trauma and discomfort to the patient during a second operation, the present invention provides a degradable airbag device for preventing intestinal anastomotic leakage. Through innovative airbag design and bionic fixation, multiple sealing layers can be formed around the anastomosis to ensure that the device will not be displaced during the tissue repair process, effectively protect the intestinal anastomosis from being affected by dirt in the intestine, prevent leakage of intestinal contents, reduce the occurrence of anastomotic leakage, promote postoperative healing, and improve the patient's postoperative recovery effect.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions: The present invention provides a degradable airbag device for preventing intestinal anastomotic leakage, comprising a plurality of sheet-shaped airbags, an air inlet, an air outlet, an air inlet pipe and an air outlet pipe; The plurality of sheet-like airbags are internally connected and interconnected to form a tubular inflatable structure with a hollow interior and openings at both ends. The tubular inflatable structure is provided with an air inlet and an exhaust port, the air inlet and the exhaust port are respectively connected to an air inlet pipe and an exhaust pipe, and the outer side of the sheet-like airbag is formed with a bionic adhesive surface structure; The tubular inflatable structure is inflated and expanded to form a tubular structure. The outer side of the inflated tubular inflatable structure is tightly attached to the inner surface of the intestinal wall at the anastomosis to form a supporting sealing structure. The tubular inflatable structure is deflated and collapsed inwardly. The outer side of the contracted tubular inflatable structure is separated from the inner surface of the intestinal wall at the anastomosis and removed.

[0006] Using the above technical solution: The tubular inflatable structure formed by connecting multiple sheet-like airbags is used as the main body. After inflation, it can provide sufficient support to help the anastomosis resist external forces. The internal hollow structure is used to drain intestinal contents. The outer side of the sheet-like airbag is formed with a bionic adhesion surface structure, which increases the compressive stress and friction between the sheet-like airbag and the intestinal wall, ensuring that the sheet-like airbag is fixed upstream and downstream of the anastomosis, ensuring that it will not be displaced or fall off during the tissue repair process. This makes the tubular inflatable structure close to the anastomosis, providing protection, preventing anastomotic leakage and secondary postoperative infection and poor healing. After deflation, the sheet-like airbag will collapse, which is convenient for direct removal.

[0007] Furthermore, the outer side of the sheet-like airbag is made of a degradable polyurethane material, and the inner side of the sheet-like airbag is made of a polytetrafluoroethylene material.

[0008] The outer surface of the sheet-like airbag close to the intestinal wall is made of flexible and durable polyurethane material, which can provide sufficient support after inflation. The inner surface of the sheet-like airbag away from the intestinal wall is made of polytetrafluoroethylene material, which has a lower surface energy and can prevent contamination and the residue of intestinal contents. In addition to the inner surface of the airbag made of polytetrafluoroethylene, the rest of the device is made of degradable polyurethane material, ensuring that the device can be naturally degraded after completing its task and will not cause long-term effects on the human body. The polytetrafluoroethylene material can also be excreted from the body by itself.

[0009] Furthermore, the inner side and the outer side of the sheet-like airbag are chemically modified with a chitosan quaternary ammonium salt molecular brush coating.

[0010] In specific applications, the inner polytetrafluoroethylene surface and the outer polyurethane surface of the sheet airbag are chemically modified with chitosan quaternary ammonium salt molecular brush coating, which can improve the antibacterial properties, surface hydrophilicity and biocompatibility of the degradable airbag device.

[0011] Furthermore, the specific process of chemically modifying the chitosan quaternary ammonium salt molecular brush coating on the inner and outer sides of the sheet-like airbag is as follows: S1, using a sodium-naphthalene treatment solution having a sodium to naphthalene molar ratio of 1:1 and a tetrahydrofuran solvent to react at room temperature for 1-5 hours to obtain a mixed solution A, and applying the mixed solution A to the inner side and the outer side of the sheet-shaped airbag for pretreatment; S2. Add 1-4wt% of glycerol and 0.1-0.5wt% of glutaraldehyde to a 1-10g / L chitosan quaternary ammonium salt solution to obtain a mixed solution B, and evenly apply the mixed solution B to the inner and outer surfaces of the pretreated sheet-like airbag, and cure it at 60°C to form a chitosan quaternary ammonium salt molecular brush coating on the inner and outer surfaces of the sheet-like airbag.

[0012] Furthermore, the bionic adhesive surface structure is a multi-level hexagonal protrusion array structure that imitates the foot pad of a tree frog.

[0013] The outer surface of the sheet-like airbag close to the intestinal wall is a bionic adhesive surface structure, which imitates the hexagonal multi-level protrusion array of the tree frog's foot pad. This array not only excludes the interfacial water on the surface of the intestinal wall tissue, but also forms a firm adhesion with the intestinal wall tissue through capillary force. The bionic adhesive surface structure can fix the degradable sheet-like airbag upstream and downstream of the anastomosis, ensuring that the airbag device will not be displaced during the tissue repair process.

[0014] Furthermore, an intake check valve is provided inside the intake pipe, and a pressure sensor is provided between the intake pipe and an external air pump.

[0015] The intake pipe is made of degradable polyurethane material, which is flexible and pressure-resistant, thus ensuring smooth gas flow. It connects the tubular inflatable structure and the external air pump to transport gas into the tubular inflatable structure. The intake pipe has a built-in intake check valve to prevent gas backflow and ensure stable pressure after inflation. A commercial pressure sensor can be grafted between the intake pipe and the external air pump to automatically adjust the gas flow and pressure based on real-time monitoring data.

[0016] Furthermore, a knob-type air valve is provided at the end of the exhaust pipe, and an airflow control device is installed inside the knob-type air valve.

[0017] The exhaust pipe is used to control the discharge of gas from the airbag. When the protective device needs to be adjusted or deflated after use, the exhaust pipe is also made of flexible and biodegradable polyurethane material. A knob-type air valve is designed at the end of the exhaust pipe to ensure smooth and controllable discharge of gas. The valve at the end of the exhaust pipe is designed with an airflow control device that can control the flow rate and flow rate of the airflow to prevent irritation to the intestines.

[0018] Furthermore, a micro sensor for detecting pressure and temperature is placed inside the tubular inflatable structure.

[0019] In specific applications, a commercial micro sensor can be placed inside the sheet-like airbag to monitor the pressure and temperature of the anastomosis in real time to ensure the best healing environment.

[0020] Compared with the prior art, the present invention has the following beneficial effects: 1. Prevent anastomotic leakage: Through the combination of multi-layer sheet airbags and bionic adhesive surface structure, multiple sealing layers can be formed around the anastomosis and provide effective support to help the anastomosis resist external forces. The internal hollow structure is used to drain intestinal contents, effectively preventing leakage of intestinal contents and ensuring the integrity of the anastomosis.

[0021] 2. Enhance the stability of the anastomosis: Through the design of the bionic adhesion surface structure, the compressive stress and friction between the sheet-like airbag and the intestinal wall are increased, which can form a firm adhesion around the anastomosis, enhance the stability of the anastomosis, and reduce the risk of postoperative displacement.

[0022] 3. Non-invasive personalized placement: The biodegradable balloon device can be first placed upstream and downstream of the anastomosis, and then inflated in the intestinal cavity by an external air pump to form protection. The inflation degree and position of the device can be adjusted individually according to the patient's specific situation to provide the best protection effect.

[0023] 4. No need for secondary surgery to remove: All materials are made of degradable polyurethane and self-excreted polytetrafluoroethylene materials, which will not cause long-term effects on the human body.

[0024] 5. Improved antibacterial properties of the device: The inner polytetrafluoroethylene and outer polyurethane surfaces of the sheet-like airbag are chemically modified with chitosan quaternary ammonium salt molecular brush coatings, which can improve the antibacterial properties, surface hydrophilicity and biocompatibility of the degradable airbag device.

[0025] 6. Reduce the patient's physical and mental pain and economic burden: By reducing postoperative complications and shortening hospital stays, patients can return to normal life faster and reduce the psychological pressure and economic burden caused by long-term hospitalization. At the same time, the simple design of the device reduces the complexity and time of postoperative care, further reducing the patient's overall medical expenses. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] The present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0027] Figure 1 It is a schematic diagram of the overall structure of the degradable airbag device of the present invention; Figure 2 It is a schematic diagram of the structure of the outer side of the degradable airbag device in the present invention when it is in the deployed state; Figure 3 This is a 3D modeling diagram of the bionic adhesion surface structure of the present invention, with a modeling accuracy of micrometer level, including a two-level protrusion structure; Figure 4 It is a schematic structural diagram of the inner side of the degradable airbag device in the present invention when it is in an expanded state; Figure 5This is a schematic diagram of the use state of the degradable airbag device of the present invention placed at the anastomosis; Figure 6 This is a water contact angle experiment on the surface of the polyurethane material modified by the chitosan quaternary ammonium salt molecular brush in the present invention; Figure 7 It is the fluorescence staining pattern of the anti-Escherichia coli experiment of the polyurethane material and the polytetrafluoroethylene material modified by the chitosan quaternary ammonium salt molecular brush in the present invention; Among them, the specific drawings are marked as: Sheet-shaped airbag 1, bionic adhesion surface structure 2, tubular inflatable structure 3, air inlet 4, exhaust port 5, air inlet pipe 6, exhaust pipe 7. DETAILED DESCRIPTION

[0028] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0029] Example 1 A degradable balloon device for preventing intestinal anastomotic leakage, such as Figures 1 to 5 As shown, it includes multiple sheet-like airbags 1, an air inlet 4, an air outlet 5, an air inlet pipe 6 and an air outlet 7; the multiple sheet-like airbags 1 are internally connected and interconnected to form a tubular inflatable structure 3 which is hollow inside and open at both ends, the tubular inflatable structure 3 is provided with an air inlet 4 and an air outlet 5, the air inlet 4 and the air outlet 5 are respectively connected to the air inlet pipe 6 and the air outlet 7, and the outer side of the sheet-like airbag 1 is formed with a bionic adhesion surface structure 2; the tubular inflatable structure 3 is inflated and expanded to form a tubular structure, the outer side of the inflated tubular inflatable structure 3 is tightly attached to the inner surface of the intestinal wall at the anastomosis to form a supporting sealing structure, the tubular inflatable structure 3 is deflated and collapsed and contracted inwardly, and the outer side of the contracted tubular inflatable structure 3 is separated from the inner surfaces of the intestinal wall at the anastomosis for removal. In specific applications, the number of sheet airbags 1 is an even number, and the sheet airbags 1 are connected in sequence to form a cylindrical structure with openings at both ends and a hollow interior. When inflated, the sheet airbags 1 expand to form a hollow tubular structure. After deflation, the sheet airbags 1 collapse to form a sheet, and the tubular inflatable structure 3 shrinks into a sheet structure. In this embodiment, 8 sheet airbags 1 are provided, of which 2 sheet airbags 1 form a group, and four groups of sheet airbags are connected to form a cylindrical structure with openings at both ends and a hollow interior.

[0030] The tubular inflatable structure 3 formed by connecting multiple sheet-like airbags 1 is used as the main body. After inflation, it can provide sufficient support to help the anastomosis resist external forces. The internal hollow structure is used to drain intestinal contents. The outer side of the sheet-like airbag 1 is formed with a bionic adhesion surface structure 2, which increases the compressive stress and friction between the sheet-like airbag 1 and the intestinal wall, ensuring that the sheet-like airbag 1 is fixed upstream and downstream of the anastomosis, ensuring that it will not be displaced or fall off during the tissue repair process, so that the tubular inflatable structure 3 is close to the anastomosis, providing protection, preventing anastomotic leakage and secondary postoperative infection and poor healing. After deflation, the sheet-like airbag 1 will collapse, which is convenient for direct removal.

[0031] The outer side of the sheet-like airbag 1 is made of degradable polyurethane material, and the inner side of the sheet-like airbag 1 is made of polytetrafluoroethylene material. The outer surface of the sheet-like airbag 1 close to the intestinal wall is made of flexible and durable polyurethane material, which can provide sufficient support after inflation. The inner surface of the sheet-like airbag 1 away from the intestinal wall is made of polytetrafluoroethylene material, which has a lower surface energy and can prevent contamination and the residue of intestinal contents. In addition to the inner surface of the airbag made of polytetrafluoroethylene, the rest of the device is made of degradable polyurethane material, ensuring that the device can be naturally degraded after completing its task and will not cause long-term effects on the human body, and the polytetrafluoroethylene material can also be excreted from the body by itself.

[0032] Among them, an intake check valve is provided inside the intake pipe 6, and a pressure sensor is provided between the intake pipe 6 and the external air pump. The intake pipe 6 is made of a degradable polyurethane material, which is flexible and pressure-resistant, thereby ensuring smooth flow of gas. It connects the tubular inflatable structure 3 and the external air pump to transport gas into the tubular inflatable structure 3. The intake pipe 6 has a built-in intake check valve to prevent gas backflow and ensure stable pressure after inflation. A commercial pressure sensor can be grafted between the intake pipe 6 and the external air pump, which can automatically adjust the gas flow and pressure according to real-time monitoring data.

[0033] Among them, a knob-type air valve is provided at the end of the exhaust pipe 7, and an airflow control device is installed inside the knob-type air valve. The exhaust pipe 7 is used to control the discharge of gas from the airbag. When the protective device needs to be adjusted or deflated after use, the exhaust pipe 7 is also made of flexible and degradable polyurethane material. A knob-type air valve is designed at the end of the exhaust pipe 7 to ensure smooth and controllable discharge of gas. The valve at the end of the exhaust pipe 7 is designed with an airflow control device, which can control the flow rate and flow rate of the airflow to prevent irritation to the intestines.

[0034] A micro sensor for detecting pressure and temperature is placed inside the tubular inflatable structure 3. In specific applications, a commercial micro sensor can be placed inside the sheet-like airbag 1 to monitor the pressure and temperature of the anastomosis in real time to ensure the best healing environment.

[0035] The bionic adhesive surface structure 2 is a multi-level hexagonal protrusion array structure that imitates the foot pad of a tree frog. The outer surface of the sheet-like airbag 1 close to the intestinal wall is a bionic adhesive surface structure 2 that imitates the hexagonal multi-level protrusion array of the foot pad of a tree frog. This array not only removes the interfacial water on the surface of the intestinal wall tissue, but also forms a strong adhesion with the intestinal wall tissue through capillary force. The bionic adhesive surface structure 2 can fix the degradable sheet-like airbag 1 upstream and downstream of the anastomosis to ensure that the airbag device will not be displaced during the tissue repair process. Figure 3 As shown, in a specific embodiment, the bionic adhesion surface structure 2 is a two-level hexagonal protrusion array structure that imitates the foot pad of a tree frog, and there are channels between the multiple levels of protrusions. This array structure not only excludes interfacial water on the surface of the intestinal wall tissue, but also forms a firm adhesion with the intestinal wall tissue through capillary force.

[0036] The inner and outer surfaces of the sheet-like airbag 1 are chemically modified with chitosan quaternary ammonium salt molecular brush coatings. In specific applications, the inner polytetrafluoroethylene surface and the outer polyurethane surface of the sheet-like airbag 1 are chemically modified with chitosan quaternary ammonium salt molecular brush coatings, which can improve the antibacterial property, surface hydrophilicity and biocompatibility of the degradable airbag device.

[0037] Specifically, the specific process of chemically modifying the chitosan quaternary ammonium salt molecular brush coating on the inner and outer sides of the sheet-like airbag 1 is as follows: S1, using a sodium-naphthalene treatment solution having a sodium to naphthalene molar ratio of 1:1 and a tetrahydrofuran solvent to react at room temperature for 1-5 hours to obtain a mixed solution A, and applying the mixed solution A to the inner side and the outer side of the sheet-shaped airbag for pretreatment; S2. Add 1-4wt% of glycerol and 0.1-0.5wt% of glutaraldehyde to a 1-10g / L chitosan quaternary ammonium salt solution to obtain a mixed solution B, and evenly apply the mixed solution B to the inner and outer surfaces of the pretreated sheet-like airbag, and cure it at 60°C to form a chitosan quaternary ammonium salt molecular brush coating on the inner and outer surfaces of the sheet-like airbag.

[0038] Figure 6 This is a water contact angle experiment on the surface of polyurethane material modified with chitosan quaternary ammonium salt molecular brushes. The surface of polyurethane material modified with chitosan quaternary ammonium salt molecular brushes shows good hydrophilicity.

[0039] Figure 7The fluorescence staining pattern of the anti-E. coli experiment of the polyurethane material and polytetrafluoroethylene material modified with chitosan quaternary ammonium salt molecular brush, among which the blank control group (polyurethane material without chitosan quaternary ammonium salt molecular brush coating on the surface) has obvious fluorescence, indicating that there are a large number of E. coli. The other two groups have basically no fluorescence, which proves its antibacterial ability and shows that the inner polytetrafluoroethylene and outer polyurethane surfaces of the sheet airbag 1 are chemically modified with chitosan quaternary ammonium salt molecular brush coating, which can improve the antibacterial property of the degradable airbag device.

[0040] Example 2 The production process of the degradable airbag device: 1) Material selection: a) A flexible and degradable polyurethane material is used as the tubular inflatable structure 3 close to the outer surface of the intestinal wall to ensure that it can expand when inflated and shrink in volume after deflation.

[0041] b) The inner surface of the tubular inflatable structure 3 away from the intestinal wall is made of polytetrafluoroethylene material with anti-fouling properties.

[0042] c) The intake pipe 6 and the exhaust pipe 7 are also made of biodegradable polyurethane.

[0043] 2) Production of biodegradable airbag device: a) A degradable polyurethane film with a thickness of 100 μm was prepared by a film-forming process as a tubular inflatable structure 3 close to the outer surface of the intestinal wall. A multi-level hexagonal convex structure imitating the foot pad of a tree frog was given to the surface of the degradable polyurethane film by a hot embossing process.

[0044] b) A polytetrafluoroethylene film with a thickness of 100 μm is prepared by a film-forming process as the inner surface of the tubular inflatable structure 3 away from the intestinal wall, and is cut to match the shape of the outer surface of the tubular inflatable structure 3 .

[0045] c) The intake pipe 6, the intake check valve and the exhaust pipe 7 are prepared by injection molding.

[0046] d) The above structures are assembled together by ultrasonic thermal welding process, and hot pressing is used to separate the whole into 8 distributed airbags.

[0047] Example 3 Insertion and removal of the biodegradable balloon device: 1) Placement at the intestinal anastomosis: a) Guide the uninflated biodegradable balloon device to the intestinal anastomosis of the patient through an endoscope, ensuring that the two ends of the device are respectively at the upper and lower ends of the anastomosis, so as to form effective support and protection after inflation.

[0048] 2) Inflation: a) Connect an external air pump to the device through the air inlet tube 6 and slowly inject gas to gradually expand the degradable balloon device to the desired size. During the inflation process, the internal pressure needs to be closely monitored to ensure that the balloon provides sufficient support while avoiding excessive pressure on the intestine.

[0049] b) After inflation is completed, confirm the function of the air inlet check valve to prevent gas backflow and ensure that the pressure of the degradable airbag device remains stable.

[0050] 3) Functional implementation: a) After the biodegradable balloon device is inflated, it can effectively support and protect the anastomosis, resist mechanical stress, and prevent anastomotic leakage.

[0051] b) The multi-level hexagonal protrusion structure of the bionic tree frog foot pad removes interfacial water on the surface of the intestinal wall tissue and forms a strong adhesion with the intestinal wall tissue through capillary force, ensuring that the device will not move or fall off during use.

[0052] 4) Take out as needed: a) After use, the exhaust pipe 7 is deflated by unscrewing the knob of the rotary air valve, so that the tubular inflatable structure 3 collapses, which is convenient for direct removal.

[0053] b) When active removal is not necessary, wait for the polyurethane component of the degradable airbag device to degrade on its own and for the polytetrafluoroethylene component to be discharged on its own.

[0054] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A degradable airbag device for preventing intestinal anastomotic leakage, characterized in that: It includes a plurality of sheet-shaped air bags, an air inlet, an air outlet, an air inlet pipe and an exhaust pipe; The plurality of sheet-like airbags are internally connected and interconnected to form a tubular inflatable structure with a hollow interior and openings at both ends. The tubular inflatable structure is provided with an air inlet and an exhaust port, the air inlet and the exhaust port are respectively connected to an air inlet pipe and an exhaust pipe, and the outer side of the sheet-like airbag is formed with a bionic adhesive surface structure; The tubular inflatable structure is inflated and expanded to form a tubular structure. The outer side of the inflated tubular inflatable structure is tightly attached to the inner surface of the intestinal wall at the anastomosis to form a supporting sealing structure. The tubular inflatable structure is deflated and collapsed inwardly. The outer side of the contracted tubular inflatable structure is separated from the inner surface of the intestinal wall at the anastomosis and removed.

2. The degradable airbag device for preventing intestinal anastomotic leakage according to claim 1, characterized in that: The outer side of the sheet-like airbag is made of a degradable polyurethane material, and the inner side of the sheet-like airbag is made of a polytetrafluoroethylene material.

3. The degradable airbag device for preventing intestinal anastomotic leakage according to claim 2, characterized in that: The inner side and the outer side of the sheet-like airbag are both chemically modified with chitosan quaternary ammonium salt molecular brush coatings.

4. The degradable airbag device for preventing intestinal anastomotic leakage according to claim 3, characterized in that: The specific process of chemically modifying the chitosan quaternary ammonium salt molecular brush coating on the inner and outer sides of the sheet-like airbag is as follows: S1, using a sodium-naphthalene treatment solution having a sodium to naphthalene molar ratio of 1:1 and a tetrahydrofuran solvent to react at room temperature for 1-5 hours to obtain a mixed solution A, and applying the mixed solution A to the inner side and the outer side of the sheet-shaped airbag for pretreatment; S2. Add 1-4wt% of glycerol and 0.1-0.5wt% of glutaraldehyde to a 1-10g / L chitosan quaternary ammonium salt solution to obtain a mixed solution B, and evenly apply the mixed solution B to the inner and outer surfaces of the pretreated sheet-like airbag, and cure it at 60°C to form a chitosan quaternary ammonium salt molecular brush coating on the inner and outer surfaces of the sheet-like airbag.

5. The degradable balloon device for preventing intestinal anastomotic leakage according to claim 1, characterized in that: The bionic adhesive surface structure is a multi-level hexagonal protrusion array structure that imitates the foot pad of a tree frog.

6. The degradable balloon device for preventing intestinal anastomotic leakage according to claim 1, characterized in that: An intake check valve is arranged inside the intake pipe, and a pressure sensor is arranged between the intake pipe and an external air pump.

7. The degradable balloon device for preventing intestinal anastomotic leakage according to claim 6, characterized in that: A knob-type air valve is provided at the end of the exhaust pipe, and an airflow control device is installed inside the knob-type air valve.

8. The degradable balloon device for preventing intestinal anastomotic leakage according to claim 7, characterized in that: A micro sensor for detecting pressure and temperature is placed inside the tubular inflatable structure.

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