Method for constructing tracheal stent model, tracheal stent model and related equipment

Abstract

The invention belongs to the technical field of medical instruments, and discloses a method for constructing a tracheal stent model, the tracheal stent model and related equipment, and the method comprises the following steps: obtaining a tracheal scanning image containing a defect part and an adjacent healthy part; according to the trachea scanning image, the distance between the top cartilage ring and the bottom cartilage ring adjacent to the trachea defect part and the trachea longitudinal change trend of the healthy part are obtained. According to the distance between the top cartilage ring and the bottom cartilage ring and the longitudinal change trend of the trachea, a first model in a C-shaped cylindrical ring shape is constructed; and smoothing the surface of the inner cavity of the first model to obtain a second model. The second model is hollowed out according to a preset hollowed-out area, and the tracheal stent model is obtained. According to the method, the tracheal stent model which is similar to the original form of the tracheal defect part and is light in weight and uniform in strength can be obtained, and personalized tracheal stent models can be provided for different patients.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and more specifically, to a method for constructing a tracheal stent model, a tracheal stent model and related equipment. Background Art

[0002] Currently, one of the treatment methods for diseases such as tracheal defects, congenital and acquired tracheal chondromalacia is to place a stent inside the tracheal defect and use a tracheal substitute to reconstruct the trachea.

[0003] An ideal tracheal substitute needs to meet many conditions, such as: good biocompatibility, tough and elastic texture, good air tightness, good mechanical strength and deformation resistance to resist changes in respiratory pressure without collapse, able to be absorbed by human tissue, provide a permanent stent function, be able to integrate well with surrounding tissues without tension and avoid inflammatory response, allow respiratory epithelial cells to grow on it, and the airway surface can be covered by normal mucosa, etc.

[0004] At present, the biomaterials used in tracheal prostheses are mainly divided into rigid materials and flexible materials. Rigid materials include: titanium metal, polypropylene fiber mesh, hydroxyapatite, carbon fiber composite materials, etc. Flexible materials include: various polymer materials such as polytetrafluoroethylene, silicone, etc.

[0005] There are various problems with current tracheal substitutes. For example, the size of the mass-produced tracheal substitutes cannot fully match the defective trachea of ​​the patient, and they need to be cut and processed before or during surgery, which is cumbersome and prolongs the operation time, aggravates the patient's discomfort, and is not conducive to the patient's recovery. The process of removing the substitute again is difficult and the surgical risk is high.

[0006] For another example, after a tracheal substitute is implanted in a human body, it is subjected to pressure from the respiratory tract for a long time, causing the tracheal substitute to deform, the inner cavity to narrow, or even become blocked.

[0007] For another example, tracheal substitutes have too high mechanical strength and insufficient elasticity, and cannot be well integrated with surrounding tissues, resulting in wear and loose connections with surrounding tissues, leading to inflammatory reactions or falling off.

[0008] In view of this, there is an urgent need to provide a technical solution for constructing a tracheal stent, so that the tracheal stent has good adaptability, good mechanical strength and deformation resistance, and can be well combined with surrounding tissues without tension. Summary of the invention

[0009] In order to at least solve one or more of the technical problems mentioned above, according to one aspect of the present invention, a method for constructing a tracheal stent model is provided, comprising: obtaining a tracheal scanning image including a defect site and an adjacent healthy site; obtaining, based on the tracheal scanning image, the distance between the top cartilage ring and the bottom cartilage ring adjacent to the defect site, and the longitudinal change trend of the trachea in the healthy site; constructing a first model in the shape of a C-shaped cylindrical ring based on the distance between the top cartilage ring and the bottom cartilage ring and the longitudinal change trend of the trachea; smoothing the inner cavity surface of the first model to obtain a second model; and hollowing out the second model according to a pre-set hollow area to obtain a tracheal stent model.

[0010] According to one embodiment of the present invention, the length of the first model is set to be less than or equal to the distance between the top cartilage ring and the bottom cartilage ring.

[0011] According to one embodiment of the present invention, obtaining a tracheal scanning image including a defective part and a healthy part includes: obtaining CT scanning data from the glottis of the trachea to the lower edge of the trachea to form a tracheal scanning image.

[0012] According to one embodiment of the present invention, the slice thickness of the CT scan data does not exceed 0.625 mm.

[0013] According to one embodiment of the present invention, the longitudinal change trend of the trachea in the healthy part is obtained by comparing adjacent CT scan data.

[0014] According to one embodiment of the present invention, the hollow area is determined by the following method: lateral supports are set on the second model according to the number and position of the missing cartilage rings in the defect site; longitudinal supports are set on both sides of the C-shaped second model; and the lateral supports and longitudinal supports are avoided on the side walls of the second model to determine the hollow area.

[0015] According to one embodiment of the present invention, determining the number and position of missing cartilage rings in a tracheal defect site includes: obtaining the distance between the top cartilage ring and the bottom cartilage ring to obtain a first length; obtaining the spacing between the cartilage rings in a healthy site to obtain a second length; taking the quotient of the first length and the second length and rounding it to obtain a first number of missing cartilage rings; and evenly arranging the first number of cartilage rings within the first length range to determine the number and position of missing cartilage rings in the tracheal defect site.

[0016] According to one embodiment of the present invention, hollowing out the second model includes: simulating a force analysis of the tracheal stent model, and determining the type and size of the hollowed-out mesh for the hollowing-out process.

[0017] According to another aspect of the present invention, a tracheal stent model is provided, including: the tracheal stent model is in a C-shaped cylindrical ring, including multiple lateral supports and vertical supports and a hollow grid; the tracheal stent model is constructed by the aforementioned method.

[0018] According to another aspect of the present invention, a method for 3D printing a tracheal stent is provided, comprising: 3D printing the aforementioned tracheal stent model made of titanium metal raw material to obtain the tracheal stent.

[0019] According to another aspect of the present invention, there is provided a device for constructing a tracheal stent model, comprising: a processor for executing program instructions; and a memory storing program instructions, wherein when the program instructions are loaded and executed by the processor, the processor executes the aforementioned method for constructing a tracheal stent model.

[0020] According to another aspect of the present invention, a non-volatile computer-readable storage medium is provided, on which computer-readable instructions are stored. When the computer-readable instructions are executed by one or more processors, the aforementioned method for constructing a tracheal stent model is implemented.

[0021] In an embodiment of the present invention, the size of the defective part is obtained through a tracheal scanning image, and the tracheal morphology of the defective part is simulated through the longitudinal change trend of the trachea in the adjacent healthy part, so that a tracheal stent model similar to the original morphology of the tracheal defective part can be obtained, and a personalized tracheal stent model can be provided for different patients. By setting lateral supports according to the missing cartilage rings, the formed tracheal stent model is morphologically closer to the original morphology of the trachea. Vertical supports are supplemented by mechanical analysis, and hollow areas are set to avoid vertical supports and lateral supports, thereby achieving the unification of lightweight and strength requirements of the tracheal stent model. The change trend of the trachea in the longitudinal direction in the healthy part is obtained by comparing adjacent CT scan data, so that the longitudinal changes of the constructed tracheal stent model are closer to the real trachea. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] By reading the following detailed description with reference to the accompanying drawings, the above and other objects, features and advantages of the exemplary embodiments of the present invention will become readily understood. In the accompanying drawings, several embodiments of the present invention are shown in an exemplary and non-limiting manner, and the same or corresponding reference numerals represent the same or corresponding parts, wherein:

[0023] Figure 1 A schematic diagram showing the steps of a method for constructing a tracheal stent model according to an embodiment of the present invention is shown;

[0024] Figure 2 A schematic diagram of a tracheal scanning image according to an embodiment of the present invention is shown;

[0025] Figure 3A schematic diagram of a first model according to an embodiment of the present invention is shown;

[0026] Figure 4 A schematic diagram showing a tracheal scan image with a defective portion cut off according to an embodiment of the present invention is shown;

[0027] Figure 5 A schematic diagram showing a tracheal scan image of a reconstructed defect site according to an embodiment of the present invention;

[0028] Figure 6 A schematic diagram of a tracheal stent model according to an embodiment of the present invention is shown;

[0029] Figure 7 A schematic diagram showing a comparison between a first model and a tracheal scan image according to an embodiment of the present invention is shown;

[0030] Figure 8 A schematic block diagram of a system for constructing a tracheal stent model according to an embodiment of the present invention is shown. DETAILED DESCRIPTION

[0031] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the present invention.

[0032] It should be understood that the terms "include" and "comprising" used in the description and claims of the present invention indicate the presence of described features, integers, steps, operations, elements and / or components, but do not exclude the presence or addition of one or more other features, integers, steps, operations, elements, components and / or combinations thereof.

[0033] It should also be understood that the terms used in this specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. As used in the specification of the present invention and the claims, the singular forms of "a", "an" and "the" are intended to include the plural forms unless the context clearly indicates otherwise. It should also be further understood that the term "and / or" used in the specification of the present invention and the claims refers to any combination of one or more of the associated listed items and all possible combinations, and includes these combinations.

[0034] As used in this specification and claims, the term "if" may be interpreted as "when" or "upon" or "in response to determining" or "in response to detecting," depending on the context. Similarly, the phrase "if it is determined" or "if [described condition or event] is detected" may be interpreted as meaning "upon determination" or "in response to determining" or "upon detection of [described condition or event]" or "in response to detecting [described condition or event]," depending on the context.

[0035] The specific embodiments of the present invention are described in detail below with reference to the accompanying drawings.

[0036] Figure 1 A schematic diagram of the steps of a method for constructing a tracheal stent model according to an embodiment of the present invention is shown.

[0037] Figure 2 A schematic diagram of a tracheal scanning image according to an embodiment of the present invention is shown.

[0038] Figure 3 A schematic diagram of a first model according to an embodiment of the present invention is shown.

[0039] like Figure 1 As shown, the method 100 for constructing a tracheal stent model includes: step S101, obtaining a tracheal scan image including a defect site and an adjacent healthy site. Step S102, obtaining the distance between the top cartilage ring and the bottom cartilage ring adjacent to the defect site and the longitudinal change trend of the trachea in the healthy site based on the tracheal scan image. Step S103, constructing a first model in the shape of a C-shaped cylindrical ring based on the distance between the top cartilage ring and the bottom cartilage ring and the longitudinal change trend of the trachea. Step S104, smoothing the inner cavity surface of the first model to obtain a second model. Step S105, hollowing out the second model according to a pre-set hollow area to obtain a tracheal stent model.

[0040] In an embodiment of the present invention, a construction process of an interventional prosthesis for treating tracheal and bronchial diseases is involved, the purpose of which is to produce a corresponding prosthesis according to the actual situation of the patient's tracheal defect, and implant the prosthesis to achieve the effect of restoring the physiological tracheal structure. The prosthesis constructed by the method of the embodiment of the present invention can simulate the real trachea, save the time used to bend various plastic tracheal materials during surgery, reduce the patient's pain, and is beneficial to the patient's postoperative recovery.

[0041] Specifically, in step S101, the tracheal scan image 200 can be obtained by CT tomography technology. For example, a patient with a large area of ​​tracheal defect is selected, and a 64-row spiral CT thin-layer scan is performed on the affected part, and the tracheal CT data is extracted and imported into the medical image processing software Mimics Medical 21.0 for image synthesis and processing. In the present invention, the obtained tracheal scan image includes two parts, namely, Figure 2 The tracheal defect site A and the adjacent healthy site B\C are shown. For example, the tracheal defect site and the adjacent upper healthy site and\or the adjacent lower healthy site can be obtained. Among them, the tracheal defect site limits the size of the tracheal stent model, including information such as the length and the matching relationship of the surrounding tissues. The healthy site of the trachea provides reference structures such as direction, thickness, cartilage ring, ligament, etc. for constructing the tracheal stent model, and also provides a starting position for constructing the tracheal stent model.

[0042] After obtaining the tracheal scan image, the process proceeds to step S102, where the distance between the top cartilage ring and the bottom cartilage ring adjacent to the tracheal defect and the longitudinal change trend of the trachea in the healthy part are directly read on the tracheal scan image. Figure 2 As shown, the distance between the top cartilage ring and the bottom cartilage ring is the distance between the C-shaped contours of the two tracheal cartilage rings in space. Sample points can be taken along the circumferential direction at the corresponding positions on the C-shaped contour, and multiple distance data can be read to obtain the mean or maximum value as the length parameter for limiting the tracheal stent model. The longitudinal change trend of the trachea in the healthy part refers to the thickness difference, bending, bending angle and other characteristics of the trachea along the longitudinal extension direction, as the shape parameter for limiting the tracheal stent model. The acquisition process of the above-mentioned length parameters and shape parameters can be achieved by existing graphics tracking software or recognition software, which will not be described in detail in the present invention.

[0043] In step S103, after obtaining the length parameter and the shape parameter, a first model 300 in the shape of a C-shaped cylindrical ring is constructed between the top cartilage ring and the bottom cartilage ring according to the change trend and distance. The starting point of the construction can be the top cartilage ring or the bottom cartilage ring. According to one embodiment of the present invention, the first model is in the shape of a C-shaped curled sheet, and its thickness is set to between 0.3-1.5 mm, preferably 0.5 mm or 1 mm.

[0044] After obtaining the first model, it is also necessary to smooth the inner wall thereof, and enter step S104, and obtain the second model after smooth processing. For example, the first model is processed in Geomatic Wrap to smooth the surface, remove the relatively uneven local features, and obtain a roughly uniform second model. The smooth inner wall in the second model is conducive to forming a smooth airway.

[0045] The sheet-like stent model is not conducive to the attachment of endothelial cells and compatibility with surrounding tissues. In an embodiment of the present invention, in step S105, the second model is hollowed out to obtain a tracheal stent model. The role of the hollowing process includes two aspects: on the one hand, the tracheal stent model is lightweight, and on the other hand, it is convenient for endothelial cells to grow in the hollow space and enhance the compatibility of the tracheal stent with surrounding tissues.

[0046] In an embodiment of the present invention, by acquiring a tracheal scan image including a defective part and an adjacent healthy part, information on size and shape is provided for constructing a tracheal stent model of the defective part, and by referring to the change trend of the healthy part, the constructed tracheal stent model is closer to the original form of the trachea itself. By smoothing the inner wall of the first model, the airway is smooth. By hollowing out the second model, the tracheal stent model is made lightweight and easy to combine with surrounding tissues.

[0047] According to one embodiment of the present invention, the length of the first model is set to be less than or equal to the distance between the top cartilage ring and the bottom cartilage ring. The positions of the top cartilage ring adjacent to the upper end of the tracheal defect and the bottom cartilage ring adjacent to the lower end define the upper limit of the length of the tracheal stent model. By limiting the length of the first model to be less than the distance between the two, the tracheal prosthesis constructed according to the tracheal stent model can be easily installed, avoiding excessive resection of healthy parts during surgery.

[0048] like Figure 2 As shown, specifically, obtaining a tracheal scan image including a tracheal defect site and a healthy site includes: obtaining CT scan data from the glottis of the trachea to the lower edge of the trachea to form a tracheal scan image. The tracheal scan image includes a defect site A, and healthy sites B and C. The process of obtaining the tracheal scan image includes: obtaining CT data of the patient's neck, importing the CT data into Mimics, using Mimics to restore the airway, and more intuitively obtaining the site of the tracheal defect, the size of the defect, and the upper and lower relationship of the defect, and determining the grayscale value of the tracheal cartilage, and after exporting the complete model of the tracheal cartilage, finding the defect site.

[0049] Figure 4 A schematic diagram of a tracheal scan image with a defective portion cut off according to an embodiment of the present invention is shown.

[0050] Figure 5 A schematic diagram showing a tracheal scan image of a reconstructed defect site according to an embodiment of the present invention is shown.

[0051] like Figure 4 and Figure 5As shown, based on the tracheal scanning image, the defective part A is cut off to obtain image 400. Based on image 400, the length of the tracheal cartilage area that needs to be supplemented after the defective part is cut off is measured, and the number of tracheal cartilage rings that are missing is determined, and the defect is reconstructed according to the morphology of normal tracheal cartilage rings. The interfaces at the top C and the bottom B of the missing part are both atrophied, which is inconsistent with the original morphology of the trachea. The stent model is constructed by starting with the relatively normal tracheal cartilage rings above and below the missing part, so that the reconstructed tracheal stent model can be more consistent with the original morphology of the missing part. The reconstructed structure is image 500.

[0052] According to one embodiment of the present invention, the layer thickness of the CT scan data is 0.625 mm. The layer thickness of the scan data is related to the image accuracy. When the layer thickness of the CT scan data is set to 0.625 mm, when obtaining the change trend of the trachea along the longitudinal direction, the calculation accuracy is based on each layer or a combination of multiple layers, and an accurate change trend can be obtained.

[0053] According to one embodiment of the present invention, the change trend of the trachea in the longitudinal direction in the healthy part is obtained by comparing adjacent CT scan data. The adjacent CT scan data refers to adjacent layers. The change trend includes the change of the inner wall and the change of the outer wall.

[0054] According to one embodiment of the present invention, the hollow area is determined by the following method: according to the number and position of the missing cartilage rings in the tracheal defect, a transverse support is provided along the side wall of the second model. A longitudinal support is provided on both sides of the C-shaped second model in the same direction as the extension direction thereof. The transverse support and the longitudinal support are avoided on the side wall of the second model to determine the hollow area.

[0055] A transverse support is provided at the position corresponding to the missing cartilage ring, and is extended transversely to form a C-shape. The longitudinal support and the transverse support intersect at the positions of the two wings of the C-shaped cross section, and are used to strengthen the mechanical strength of the tracheal stent model in the longitudinal direction. The sizes of the longitudinal support and the transverse support are determined by mechanical strength testing. The transverse support can be set with reference to the size of the original tracheal cartilage ring, and can also be larger or smaller than the size.

[0056] According to one embodiment of the present invention, determining the position and number of cartilage rings missing from a tracheal defect includes: obtaining a distance between a top cartilage ring and a bottom cartilage ring to obtain a first length. Obtaining a spacing between cartilage rings in a healthy part of the trachea to obtain a second length. Taking the quotient of the first length and the second length and rounding it to obtain a first number of missing cartilage rings. Evenly arranging the first number of cartilage rings within the first length range to determine the position and number of cartilage rings missing from the tracheal defect.

[0057] The position of the defect is determined by obtaining the tracheal scanning image. After the defect is cut off, the distance between the top cartilage ring and the bottom cartilage ring can be directly read. By measuring the thickness and spacing of the cartilage rings in the healthy part, the distance between the midlines of adjacent cartilage rings is taken as the second length. The quotient of the first length and the second length is rounded to obtain the number of missing cartilage rings. Starting from the top cartilage ring or the bottom cartilage ring, the missing cartilage rings are set one by one to obtain the position of the cartilage ring of the complete defect.

[0058] According to an embodiment of the present invention, hollowing out the second model includes: simulating the force analysis of the tracheal stent model to determine the type and size of the hollowing mesh for the hollowing process. For example, the hollowing mesh can be set to a diamond, circle, ellipse, etc.

[0059] The purpose of hollowing out is to achieve lightweight and improve the degree of integration with surrounding tissues. The lightweight design principle and the mechanical strength of the stent are contradictory. How to achieve lightweight while ensuring sufficient mechanical strength of the stent, and how to achieve the best balance between mechanical strength and easy-to-integrate personalized structure are the core issues of hollowing out. Based on this, the inventors conducted a force analysis of the tracheal stent model, simulating the effects of air pressure changes and squeezing of surrounding tissues on the trachea during breathing, and determined the type and aperture of the hollow mesh. For example, the model is imported into the three-dimensional finite element analysis software Ansys Workbench 19.1 for material assignment, meshing, contact definition, and force analysis and solution, and then the stress and strain of different thicknesses when subjected to 6 different forces are analyzed.

[0060] Figure 6 A schematic diagram of a tracheal stent model according to an embodiment of the present invention is shown.

[0061] like Figure 6 As shown, a tracheal stent model 600 includes: the tracheal stent model is in a C-shaped cylindrical ring, including a plurality of lateral supports 601 and vertical supports 602 and a hollow grid. The tracheal stent model is constructed by the above method.

[0062] According to one embodiment of the present invention, a method for 3D printing a tracheal stent is provided, comprising: preparing a titanium metal raw material according to Figure 5 The designed titanium metal tracheal stent model is 3D printed to obtain a tracheal stent. The designed titanium metal tracheal stent model is printed using 3D printing technology to obtain a titanium metal stent, which can be installed in the patient's tracheal defect through surgery.

[0063] Materials such as titanium are widely used in implant medicine due to their stable physical and chemical properties and excellent low foreign body reaction performance. They have good elasticity, provide support for the tracheal cavity, and have certain stretching, bending and anti-torsion effects. Metal mesh artificial trachea can be called a better internal stent, so in clinical practice and research, artificial trachea with higher affinity is often made by coating biomaterials with metal materials or wrapping autologous tissues. Therefore, the embodiment of the present invention uses titanium metal materials to design a gridded titanium metal tracheal stent.

[0064] Example: Process of 3D printing a personalized tracheal repair prosthesis for a tracheal defect patient

[0065] Using 3D printing technology, a tracheal prosthesis is customized for patients with tracheal defects and tracheal softening. It is inserted from the outside of the trachea to fill the tracheal defect and remove the softened part of the trachea, or the tracheal prosthesis is fixed to the softened part of the trachea to compensate for supporting dysfunctions such as tracheal collapse caused by various reasons.

[0066] The first step is to use 64-row spiral CT to scan the trachea of ​​patients with tracheal defects. The specific scanning parameters are: 140kV, 200MA, and a layer thickness of 0.625mm to obtain tracheal scanning data. The scanning range is: from the glottis to the lower edge of the trachea. The obtained data is stored in the international standard DICOM format and output on a CD.

[0067] In the second step, after the scan data was input, the contrast of the imported image was adjusted through the image generation and editing software Mimics Medical 21.0 (Materialise, Belgium) to obtain a clearer tracheal scan image. Then, the CT data of the missing part of the trachea was obtained through image segmentation.

[0068] In the third step, the Region growing command of Mimics Medical 21.0 software was used to perform regional growing and artifact elimination operations, and the Segmentation Editmasks and Smoothing commands were used to further edit and smooth the first model. The Calculate 3D command was run to finally obtain a relatively ideal tracheal three-dimensional model, that is, the first model, thereby realizing the three-dimensional modeling of the trachea. The model can be rotated and scaled at will, and the final data is exported in STL format.

[0069] The fourth step is to import the first model into Geomagic studio2014 in STL format, perform a series of processing such as cutting, deleting redundant parts, and smoothing, and then obtain the contralateral tracheal model sheet of the defect, that is, the second model. After the model is solidified and saved in stl format and exported, it is imported into Materialise Magics 21.0 software to design a personalized sheet of the defect area, cut and deform, and the connection between the tracheal cartilage rings is titanium wire, which plays a role in stabilizing the frame. The rest of the parts are titanium meshed using the Magics structure function to obtain 3 3D printed personalized tracheal repair prosthesis models with different thicknesses and designs. According to the shape of the outer contour, the desired shape is cut again and exported to STP format.

[0070] The 3D printed personalized tracheal repair prosthesis models include: 0.5mm thickness, 4mm titanium mesh aperture; 0.5mm thickness, the titanium mesh part is completely hollowed out leaving only the supporting pillars; 1mm thickness, 4mm titanium mesh aperture.

[0071] Figure 7 A schematic diagram of comparing the first model with a tracheal scan image according to an embodiment of the present invention is shown.

[0072] like Figure 7 As shown, the designed titanium metal tracheal stent model 600 is imported into the Mimics software to check whether it matches the upper and lower surrounding relationships. According to the comparison results, the shape of the tracheal stent model is adjusted again. The tracheal stent model 600 is placed between the healthy part B and the healthy part C, and the degree of matching can be observed from multiple angles.

[0073] In an embodiment of the present invention, the size of the defective part is obtained through a tracheal scanning image, and the original morphology of the defective part is simulated through the change trend of the healthy part, so that a tracheal stent model similar to the original morphology of the defective part can be obtained, and a personalized tracheal stent model can be provided for different patients. By setting lateral supports according to the missing cartilage rings, the formed tracheal stent model is closer to the original morphology of the trachea in terms of morphology. Vertical supports are supplemented by mechanical analysis, and hollow areas are set to avoid vertical supports and lateral supports, thereby achieving the unity of lightweight and strength of the tracheal stent model. The change trend of the trachea in the longitudinal direction in the healthy part is obtained by comparing adjacent CT scan data, so that the longitudinal changes of the constructed tracheal stent model are closer to the real trachea.

[0074] The above solution of the present invention can be implemented with the help of program instructions. Therefore, the present invention also provides a device for constructing a tracheal stent model, including: a processor, which is used to execute program instructions; and a memory, which stores program instructions, when the program instructions are loaded and executed by the processor, the processor executes the method for constructing a tracheal stent model as described above.

[0075] Figure 8 A schematic block diagram of a system for constructing a tracheal stent model according to an embodiment of the present invention is shown. The system 800 may include a device 801 according to an embodiment of the present invention and its peripheral devices and external network, wherein the device 801 is used to construct the tracheal stent model to implement the above technical solution.

[0076] like Figure 8 As shown in , the device 801 may include a CPU 8011, which may be a general-purpose CPU, a dedicated CPU, or other information processing and program execution units. Further, the device 801 may also include a large-capacity memory 8012 and a read-only memory ROM 8013, wherein the large-capacity memory 8012 may be configured to store various types of data and various required programs, and the ROM 8013 may be configured to store the power-on self-test of the device 801, the initialization of various functional modules in the system, the basic input / output driver of the system, and the data required for booting the operating system.

[0077] Further, the device 800 also includes other hardware platforms or components, such as the TPU 8014, GPU 8015, FPGA 8016 and MLU 8017 shown. It is understood that although a variety of hardware platforms or components are shown in the device 800, this is only exemplary and not restrictive, and those skilled in the art can add or remove corresponding hardware according to actual needs. For example, the device 801 can include only a CPU as a well-known hardware platform and another hardware platform as a test hardware platform of the present invention.

[0078] The device 801 of the present invention also includes a communication interface 8018, so that it can be connected to a local area network / wireless local area network (LAN / WLAN) 805 through the communication interface 8018, and then connected to a local server 806 or to the Internet ("Internet") 807 through the LAN / WLAN. Alternatively or additionally, the device 801 of the present invention can also be directly connected to the Internet or a cellular network through the communication interface 8018 based on wireless communication technology, such as wireless communication technology based on the third generation ("3G"), fourth generation ("4G") or fifth generation ("5G") generation. In some application scenarios, the device 801 of the present invention can also access a server 808 of an external network and a possible database 809 as needed to obtain various known neural network models, data and modules, and can remotely store various measured data.

[0079] The peripheral devices of the device 801 may include a display device 802, an input device 803, and a data transmission interface 804. In one embodiment, the display device 802 may include, for example, one or more speakers and / or one or more visual displays, which are configured to perform voice prompts and / or image video displays on the computing process or detection results of the device of the present invention. The input device 803 may include, for example, a keyboard, a mouse, a microphone, a gesture capture camera, or other input buttons or controls, which are configured to receive input or user instructions for data. The data transmission interface 804 may include, for example, a serial interface, a parallel interface or a universal serial bus interface ("USB"), a small computer system interface ("SCSI"), a serial ATA, a FireWire ("FireWire"), a PCI Express, and a high-definition multimedia interface ("HDMI"), etc., which are configured for data transmission and interaction with other devices or systems.

[0080] The CPU 8011, the mass storage 8012, the read-only memory ROM 8013, the TPU 8014, the GPU 8015, the FPGA 8016, the MLU 8017 and the communication interface 8018 of the device 801 of the present invention can be connected to each other through a bus 8019, and data interaction with peripheral devices can be achieved through the bus. In one embodiment, through the bus 8019, the CPU 8011 can control other hardware components in the device 801 and its peripheral devices.

[0081] In operation, the processor CPU 8011 of the device 801 of the present invention can receive CT scan data through the input device 803 or the data transmission interface 804, and retrieve the computer program instructions or codes (such as codes involving neural networks) stored in the memory 8012 to process the received data to obtain a tracheal scan image. After the CPU 8011 determines the tracheal scan image by executing the program instructions, it can be output in the form of display on the display device 802. In addition, the device 801 can also upload the tracheal scan image to a network, such as a remote database 809, through the communication interface 8018.

[0082] It should also be understood that any module, unit, component, server, computer, terminal or device that executes instructions of the present invention examples may include or otherwise access computer-readable media, such as storage media, computer storage media or data storage devices (removable) and / or non-removable) such as disks, optical disks or tapes. Computer storage media may include volatile and non-volatile, removable and non-removable media implemented in any method or technology for storing information, such as computer-readable instructions, data structures, program modules or other data.

[0083] Based on the above, the present invention further provides a computer-readable storage medium having computer-readable instructions stored thereon. When the computer-readable instructions are executed by one or more processors, the method for constructing a tracheal stent model as described above is implemented.

[0084] The computer-readable storage medium may be any suitable magnetic storage medium or magneto-optical storage medium, such as Resistive Random Access Memory (RRAM), Dynamic Random Access Memory (DRAM), Static Random Access Memory (SRAM), Enhanced Dynamic Random Access Memory (EDRAM), High-Bandwidth Memory (HBM), Hybrid Memory Cube (HMC), etc., or any other medium that can be used to store the required information and can be accessed by an application, a module, or both. Any such computer storage medium may be part of a device or accessible or connectable to a device. Any application or module described in the present invention may be implemented using computer-readable / executable instructions that may be stored or otherwise maintained by such a computer-readable medium.

[0085] Although multiple embodiments of the present invention have been shown and described herein, it will be apparent to those skilled in the art that such embodiments are provided by way of example only. Those skilled in the art may conceive of many changes, modifications, and alternatives without departing from the thought and spirit of the present invention. It should be understood that in the process of practicing the present invention, various alternatives to the embodiments of the present invention described herein may be adopted. The appended claims are intended to define the scope of protection of the present invention, and therefore cover equivalents or alternatives within the scope of these claims.

Claims

1. A method for constructing a tracheal stent model, characterized in that: include: Obtain a tracheal scan image that includes the defect site and adjacent healthy sites; According to the tracheal scanning image, the distance between the top cartilage ring and the bottom cartilage ring adjacent to the defect site and the longitudinal change trend of the trachea in the healthy site are obtained; According to the distance between the top cartilage ring and the bottom cartilage ring and the longitudinal change trend of the trachea, a first model in a C-shaped cylindrical ring is constructed; Smoothing the inner cavity surface of the first model to obtain a second model; The second model is hollowed out according to the preset hollow area to obtain a tracheal stent model.

2. The method according to claim 1, characterized in that The length of the first model is less than or equal to the distance between the top cartilage ring and the bottom cartilage ring.

3. The method according to claim 1, characterized in that Obtaining a tracheal scan that includes the defect and adjacent healthy areas includes: Acquire CT scan data from the glottis of the trachea to the lower edge of the trachea to obtain a tracheal scan image; Wherein, the layer thickness of the CT scan data does not exceed 0.625 mm.

4. The method according to claim 1, characterized in that: The hollow area is determined by the following method: According to the number and position of the missing cartilage rings at the defect site, a lateral support is provided on the second model; Providing longitudinal supports on both sides of the second model; The lateral support and the longitudinal support are avoided on the side wall of the second model to determine the hollow area.

5. The method according to claim 4, characterized in that The number and location of the missing cartilage rings in the defect site are determined by the following method: Obtaining the distance between the top cartilage ring and the bottom cartilage ring to obtain a first length; Obtaining the distance between the cartilage rings in the healthy part to obtain a second length; Taking the quotient of the first length and the second length and rounding it to an integer, obtaining a first number of missing cartilage rings; A first number of cartilage rings are evenly arranged within a first length range, and the number and positions of the missing cartilage rings at the defect site are determined.

6. The method according to claim 1, characterized in that The type and size of the hollowed-out mesh in the hollowing process are determined by simulating the stress analysis of a tracheal stent model.

7. A tracheal stent model, characterized in that: include: The tracheal stent model is in the shape of a C-shaped cylindrical ring, including a plurality of lateral supports and vertical supports and a hollow grid; The tracheal stent model is constructed by the method according to any one of claims 1-6.

8. A method for 3D printing a tracheal stent, characterized in that: include: The titanium metal raw material is 3D printed into the tracheal stent model according to claim 7 to obtain the tracheal stent.

9. A device for constructing a tracheal stent model, characterized in that: include: a processor for executing program instructions; as well as A memory storing the program instructions, when the program instructions are loaded and executed by the processor, enables the processor to execute the method for constructing a tracheal stent model according to any one of claims 1-6.

10. A non-volatile computer-readable storage medium, characterized in that: Computer-readable instructions are stored thereon, and when the computer-readable instructions are executed by one or more processors, the method for constructing a tracheal stent model according to any one of claims 1-6 is implemented.

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