A single magnetic piezoelectric acupuncture thread and its preparation method

Abstract

This invention discloses a single magnetic piezoelectric acupuncture thread and its preparation method, relating to the field of biocomposite materials technology. The single magnetic piezoelectric acupuncture thread is a thread obtained by sequentially polarizing a dispersion of piezoelectric and magnetic materials under a high-voltage electric field, immersing it in a liquid, drawing it into threads, and drying it. The liquid used for immersion is water or a hydrogel material. This invention, by immersing the precursor solution in a specific liquid after high-voltage electric field polarization, can extract thread materials that meet the requirements of acupuncture thread embedding, achieving the goal of preparing a single acupuncture thread with both magnetic and piezoelectric properties. The prepared acupuncture thread has excellent potential for both electrical and magnetic stimulation, providing an application basis for improving the efficacy of acupuncture point therapy.

Description

Technical Field

[0001] This invention relates to the field of biocomposite materials technology, specifically to a single magnetic piezoelectric acupuncture thread and its preparation method. Background Technology

[0002] Acupuncture is an important treatment method in Traditional Chinese Medicine (TCM), which achieves the therapeutic effect by implanting threads into specific acupoints. However, the acupuncture thread embedding currently used in clinical practice relies solely on the stimulation of physiological sites by the threads themselves after being inserted into the corresponding acupoints to exert a therapeutic effect (see Zhou Tianshu et al., Visual Analysis of Research Literature on Acupuncture Treatment of Irritable Bowel Syndrome from 2013 to 2023, China Journal of Traditional Chinese Medicine Information, November 2024, Vol. 48, No. 6), lacking physical signal stimulation such as electrical or magnetic stimulation.

[0003] Existing research has shown that physical signal stimulation can promote cell and tissue function. For example, Nadia et al. prepared PVDF piezoelectric scaffolds and demonstrated their promoting effects on nerve cell attachment, diffusion and proliferation (see Abzan N. et al. Development of three-dimensional piezoelectric polyvinylidene fluoride-graphene oxide scaffold by non-solvent induced phase separation method for nerve tissue engineering[J]. Materials & Design, 2019, 167.). Another example is Adadi et al. developed PVDF films, whose generated electrical signals regulate the tissue construction activities of cardiomyocytes and induce the differentiation of human pluripotent stem cells into cardiomyocytes (see Adadi et al. Electrospun Fibrous PVDF-TrFe Scaffolds for Cardiac Tissue Engineering, Differentiation, and Maturation[J]. Advanced Materials Technologies, 2020, 5(3).). On the other hand, magnetic stimulation of magnetic materials also promotes cell function. For example, Wei found that magnetic Fe3O4 can induce stem cells to differentiate into osteoblasts (see Wei XL et al. Facet-dependence of Fe3O4 for enhancing osteogenic differentiation of BMSCs[J]. Chemical Communications,2023,59(44):6742-6744.). In actual acupuncture, the introduction of physical signal stimulation has been proven to enhance the therapeutic effect of acupuncture. However, the current traditional method of introducing physical signal stimulation in acupuncture is to apply an external electric field to generate electrical signals during the acupuncture process, which makes acupuncture equipment increasingly complex.

[0004] To address the complexity of existing acupuncture devices with magnetoelectric stimulation, using materials with piezoelectric and / or magnetic properties to prepare acupuncture threads is a promising research direction. Piezoelectric materials exhibit charge polarization upon sensing mechanical strain / stress. If magnetic materials are used to prepare acupuncture threads, the pressure exerted by the body tissue on the threads after insertion into acupoints can generate electrical signals, achieving electrical stimulation without the need for an external electric field. Similarly, magnetic materials can generate magnetic stimulation when an external magnetic field is applied. Utilizing acupuncture threads that possess both magnetic and piezoelectric properties can yield threads that provide both electrical and magnetic stimulation, significantly enhancing the acupuncture effect.

[0005] In our patent application CN114566589A, we disclosed a biomaterial exhibiting both magnetoelectric and electrochemical effects. This biomaterial combines an electroactive material with both electrical signal stimulation and piezoelectric properties with a magnetostrictive material that can elongate or shorten under external magnetic field stimulation. This composite material possesses both electrical signal stimulation capabilities and, under the influence of an external magnetic field, the magnetostrictive material responds to changes in the magnetic field by elongating or shortening along the magnetization direction, exhibiting a magnetostrictive effect. The electroactive material undergoes potential polarization due to the magnetostrictive effect, enhancing its piezoelectric effect and thus generating an electrical signal. Therefore, this magnetoelectric biomaterial can generate electrical signal stimulation in an external magnetic field without the need for electrodes, wires, or an external power source. In principle, if this biomaterial were used to prepare acupuncture threads, it could enhance the acupuncture effect regardless of whether an external magnetic field is applied. However, this document only discloses the thin film preparation method for this biomaterial; how to fabricate threads that meet the requirements remains a significant challenge. Currently, 3D printing technology can use ordinary materials to load needles with a diameter of less than 1 mm at the printing end. However, Feng et al. used 3D printing technology to construct Fe3O4 and polylactic acid (PLLA) magnetic and piezoelectric scaffolds. Due to the collapse of the material at the beginning of construction, the actual diameter of the thread expands, and the final shape of the material is a thin sheet with a thickness of 2 mm and a length of 15 mm (see Feng P. et al. Co-continuous structure enhanced magnetic responsive shape memory PLLA / TPU blend fabricated by 4D printing[J].Virtual And Physical Prototyping,2024,19(1):e2290186). However, according to the requirements of the National Standard of the People's Republic of China GB2024-2016 (the maximum diameter of acupuncture embedding thread is 0.80 mm), 3D printing technology is difficult to use to prepare acupuncture embedding threads that meet the requirements. Furthermore, the method of drawing wires after high-voltage electric field polarization makes it difficult to obtain wire material for the biomaterials mentioned in CN114566589A. Therefore, further research is needed to use the biomaterials mentioned in CN114566589A to prepare acupuncture embedding threads. Summary of the Invention

[0006] To address the aforementioned problems in the prior art, this invention provides a single magnetic piezoelectric acupuncture thread and its preparation method, thereby solving the technical problem of the difficulty in preparing single magnetic piezoelectric acupuncture threads.

[0007] The technical solution adopted in this invention is as follows:

[0008] A single magnetic piezoelectric acupuncture thread is a thread obtained by sequentially polarizing a dispersion of piezoelectric material and magnetic material under a high voltage electric field, soaking in liquid, drawing out the thread, and drying it. The liquid used in the soaking process is water or a hydrogel material.

[0009] Preferably, the piezoelectric material is polyvinylidene fluoride.

[0010] Furthermore, the magnetic material is CoFe2O4.

[0011] Furthermore, the mass fraction of the CoFe2O4 is 2-4%.

[0012] Preferably, the hydrogel material is one or more of the following: gellan gum, gelatin, chitosan, sodium alginate, collagen, hyaluronic acid, chondroitin sulfate, polyacrylamide, polyethylene glycol, polyacrylic acid, polyvinyl alcohol, polyhydroxyethyl methacrylate, and their derivatives.

[0013] The method for preparing a single magnetic piezoelectric acupuncture embedding thread includes the following steps:

[0014] (1) Preparation of magnetic material suspension;

[0015] (2) The piezoelectric material is dispersed in a solvent to form a dispersion;

[0016] (3) Mix the magnetic material suspension and the piezoelectric material dispersion, and stir non-magnetically for 2-8 hours to obtain the precursor solution;

[0017] (4) Place the precursor liquid in a high-voltage electric field polarization device with a voltage range of 8 to 22 kV;

[0018] (5) Under a high voltage electric field, the precursor solution polarized by the high voltage electric field is immersed in water or hydrogel material for 10 minutes.

[0019] (6) Using one of the following: cylindrical roller bracket, cylindrical roller, circular skeleton roller and circular skeleton roller bracket, a circumferential collection device is first pulled out and hung on the circumferential collection device, and then the circumferential collection device is used to curl and collect the single magnetic piezoelectric acupuncture embedding thread precursor.

[0020] (7) The collected single magnetic piezoelectric acupuncture embedding thread precursors are kept still for 10-16 hours, and then dried in a forced-air drying oven at a temperature of 50-100℃ for 10-16 hours to obtain the single magnetic piezoelectric acupuncture embedding thread.

[0021] Preferably, in step (6), the distance between the circumferential collecting device and the liquid immersion device is 15cm.

[0022] In summary, compared with the prior art, the present invention has the following advantages and benefits:

[0023] This invention involves immersing a precursor solution in a specific liquid after high-voltage electric field polarization treatment, thereby extracting thread materials that meet the requirements for acupuncture embedding. This achieves the goal of preparing a single acupuncture embedding thread that combines magnetic and piezoelectric properties. The prepared acupuncture embedding thread has excellent potential for electrical and magnetic stimulation, providing an application basis for improving the efficacy of acupuncture point therapy. Attached Figure Description

[0024] The present invention will be described by way of example and with reference to the accompanying drawings, wherein:

[0025] Figure 1 Physical image and optical microscope image of a single magnetic piezoelectric acupuncture thread prepared by wet process (gellan gel).

[0026] Figure 2 The results of characterizing the magnetic properties of a single magnetic piezoelectric acupuncture thread prepared by a wet process (gellan gel).

[0027] Figure 3 The piezoelectric properties characterization results of a single magnetic piezoelectric acupuncture thread prepared by a wet process (gellan gel).

[0028] Figure 4 EdU results for promoting cell proliferation activity of single magnetic piezoelectric acupuncture threads prepared by wet process (gellan gel).

[0029] Figure 5 Physical image and optical microscope image of a single magnetic piezoelectric acupuncture thread prepared by wet process (water).

[0030] Figure 6 The results of characterizing the magnetic properties of a single magnetic piezoelectric acupuncture thread prepared by a wet process (water) are shown in the figure.

[0031] Figure 7 Figure showing the piezoelectric properties characterization results of a single magnetic piezoelectric acupuncture thread prepared by a wet process (water).

[0032] Figure 8 The voltage output curve test results of single magnetic piezoelectric acupuncture embedding wires with 0, 1, 2, 3 and 4 wt.% CoFe2O4 prepared by wet process (water) are shown in the figure.

[0033] Figure 9 Hysteresis loop curves of single magnetic piezoelectric acupuncture embedding threads prepared by wet process (water) with 1, 2, 3 and 4 wt.% CoFe2O4 are shown in the figure.

[0034] Figure 10Design drawings and actual collected images of the fabrication filaments using extrusion 3D printing technology combined with wet process (gellan gel). Detailed Implementation

[0035] The preparation process of the single magnetic piezoelectric acupuncture thread provided by this invention includes the following steps:

[0036] (1) Preparation of magnetic material suspension;

[0037] (2) The piezoelectric material is dispersed in a solvent to form a dispersion;

[0038] (3) Mix the magnetic material suspension and the piezoelectric material dispersion, and stir non-magnetically for 2-8 hours to obtain the precursor solution;

[0039] (4) Place the precursor liquid in a high-voltage electric field polarization device with a voltage range of 8 to 22 kV;

[0040] (5) Under a high voltage electric field, the precursor solution polarized by the high voltage electric field is immersed in one or more liquids of water, gellan gum, gelatin, chitosan, sodium alginate, collagen, hyaluronic acid, chondroitin sulfate, polyacrylamide, polyethylene glycol, polyacrylic acid, polyvinyl alcohol, polyhydroxyethyl methacrylate and its derivatives for 10 minutes.

[0041] (6) Using one of the following: cylindrical roller bracket, cylindrical roller, circular skeleton roller and circular skeleton roller bracket, a circumferential collection device is first pulled out and hung on the circumferential collection device, and then the circumferential collection device is used to curl and collect the single magnetic piezoelectric acupuncture embedding thread precursor.

[0042] (7) The collected single magnetic piezoelectric acupuncture embedding thread precursors are kept still for 10-16 hours, and then dried in a forced-air drying oven at a temperature of 50-100℃ for 10-16 hours to obtain the single magnetic piezoelectric acupuncture embedding thread.

[0043] To make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments, wherein Embodiment 1, Embodiment 2 and Embodiment 3 are specific implementations of the present invention, and Comparative Example 1, Comparative Example 2 and Comparative Example 3 are control groups.

[0044] Example 1

[0045] This embodiment provides a single magnetic piezoelectric acupuncture thread, the preparation process of which is as follows:

[0046] S1. Prepare a suspension of CoFe2O4 and a 16 wt.% N,N-dimethylformamide solution of polyvinylidene fluoride (stir magnetically for 12 h);

[0047] S2. The CoFe2O4 suspension in S1 is mixed with the N,N-dimethylformamide solution of polyvinylidene fluoride and stirred nonmagnetically for 4 hours to prepare a mixed precursor solution;

[0048] S3. Set a high-voltage polarization electric field with an electric field strength of 15kV to treat the mixed precursor liquid with high-voltage polarization.

[0049] S4. A petri dish with a polytetrafluoroethylene stirring rod fixed on the top is set in a high-voltage polarized electric field. The petri dish is filled with gellan gel, and the mixed precursor solution after high-voltage electric field polarization is immersed in the gellan gel for 10 minutes.

[0050] S5. Add a cylindrical roller support, 15cm away from the culture dish filled with gellan gel. The gellan gel needs to be heated to maintain 70℃. Begin collecting the precursor of single magnetic piezoelectric acupuncture threads by curling them up. The relative humidity at the time of collection is 75%.

[0051] S6. The single magnetic piezoelectric acupuncture thread precursor collected by the cylindrical roller bracket is kept still for 12 hours, and then dried in a forced-air drying oven at 60℃ for 12 hours to obtain the single magnetic piezoelectric acupuncture thread.

[0052] like Figure 1 The image shown is a physical photograph and an optical microscope image of the single magnetic piezoelectric acupuncture thread prepared in this embodiment. The thread is a single strand with a diameter of 0.17 mm ± 0.014 mm. Figure 2 As shown, the saturation magnetization B of the single magnetic piezoelectric acupuncture thread prepared in this embodiment is evident. S 4.26 A·m 2 ·kg -1 This proves that it has magnetic properties.

[0053] like Figure 3 The figure shows the piezoelectric properties of the single magnetic piezoelectric acupuncture thread prepared in this embodiment. The voltage output is 0.16mV, which proves that it has obvious piezoelectric properties.

[0054] Figure 4 EdU results for promoting cell proliferation activity using a single magnetic piezoelectric acupuncture thread prepared in this embodiment show that the magnetic piezoelectric acupuncture thread composed of CoFe2O4 and polyvinylidene fluoride can significantly improve cell proliferation activity and has the biological function of an acupuncture thread.

[0055] Therefore, this embodiment successfully prepared a single magnetic piezoelectric acupuncture thread that has both piezoelectric and magnetic properties, and the magnetic piezoelectric acupuncture thread has a relatively thin diameter, which meets the national standard requirements for acupuncture threads.

[0056] Example 2

[0057] This embodiment provides a single magnetic piezoelectric acupuncture thread, the preparation process of which is as follows:

[0058] S1. Prepare a suspension of CoFe2O4 and a 16 wt.% N,N-dimethylformamide solution of polyvinylidene fluoride (stir magnetically for 12 h);

[0059] S2. The CoFe2O4 suspension in S1 is mixed with the N,N-dimethylformamide solution of polyvinylidene fluoride and stirred nonmagnetically for 4 hours to prepare a mixed precursor solution;

[0060] S3. Set a high-voltage polarization electric field with an electric field strength of 15kV to treat the mixed precursor liquid with high-voltage polarization.

[0061] S4. Set up a petri dish with a polytetrafluoroethylene stirring rod fixed on the top in a high-voltage polarized electric field, fill the petri dish with water, and immerse the mixed precursor solution after high-voltage electric field polarization in the water for 10 minutes.

[0062] S5. Add a cylindrical roller support, with the distance between the cylindrical roller support and the culture dish filled with water being 15cm. Begin to curl and collect the precursor of a single magnetic piezoelectric acupuncture thread. The relative humidity of the air during collection is 65% to 99%.

[0063] S6. The single magnetic piezoelectric acupuncture thread precursor collected by the cylindrical roller bracket is kept still for 12 hours, and then dried in a forced-air drying oven at 60℃ for 12 hours to obtain the single magnetic piezoelectric acupuncture thread.

[0064] like Figure 5 The image shown is a physical picture and an optical microscope image of the single magnetic piezoelectric acupuncture thread prepared in this embodiment. The thread is a single thread with a diameter of 0.09 mm ± 0.006 mm.

[0065] like Figure 6 As shown, the saturation magnetization B of the single magnetic piezoelectric acupuncture thread prepared in this embodiment is evident. S 3.77 A·m 2 ·kg -1 This proves that it has magnetic properties.

[0066] like Figure 7 As shown, the piezoelectric voltage output of the single magnetic piezoelectric acupuncture thread prepared in this embodiment is 0.19mV, proving that it has piezoelectric properties. Therefore, this embodiment successfully prepared a single magnetic piezoelectric acupuncture thread. Compared with the acupuncture thread obtained by soaking in water using gellan glue, the acupuncture thread obtained by soaking in water has a finer diameter and higher piezoelectric properties, but the magnetic properties are somewhat reduced.

[0067] Example 3

[0068] Based on Example 2, this embodiment explores the effect of the composition ratio of CoFe2O4 and polyvinylidene fluoride on the performance of acupuncture thread embedding. The percentages of CoFe2O4 in the total mass of CoFe2O4 and polyvinylidene fluoride were selected as 0, 1, 2, 3, 4 and 5 wt., respectively.

[0069] Among them, possibly due to the high CoFe2O4 content of 5wt.%, the high voltage polarization electric field failed to smoothly polarize the mixed precursor liquid, and ultimately a single magnetic piezoelectric acupuncture thread with a CoFe2O4 content of 5wt.% could not be prepared. Only single magnetic piezoelectric acupuncture threads with CoFe2O4 contents of 0, 1, 2, 3 and 4wt.% were prepared.

[0070] like Figure 8 The figure shows the voltage output curve test results of single magnetic piezoelectric acupuncture implantation wires prepared in this embodiment with CoFe2O4 contents of 0, 1, 2, 3, and 4 wt.%. The results show that when CoFe2O4 is 0 and 1 wt.%, the voltage output of a single magnetic piezoelectric acupuncture implantation wire is approximately 0.20 mV, with no significant change in magnitude. When CoFe2O4 is 2 wt.%, the voltage output reaches its maximum of approximately 0.55 mV. Although the voltage output decreases slightly when CoFe2O4 is 3 wt.% and 4 wt.%, it is still higher than the values ​​of 0 and 1 wt.%. Therefore, for the piezoelectric performance of single magnetic piezoelectric acupuncture implantation wires, the suitable proportion of CoFe2O4 is 2–4 wt.%. Furthermore, Figure 8 The data also show that the addition of a specific amount of CoFe2O4 can significantly improve the piezoelectric properties of the material.

[0071] like Figure 9 The figure shows the hysteresis loop curve test results of single magnetic piezoelectric acupuncture implantation wires prepared in this embodiment with CoFe2O4 contents of 1, 2, 3, and 4 wt.%. The results show that magnetic curves were tested for all four different CoFe2O4 contents of the single magnetic piezoelectric acupuncture implantation wires, with the 4 wt.% wire exhibiting the strongest magnetic properties, reaching 0.04 emu / g. Since the 0 wt.% CoFe2O4 single magnetic piezoelectric acupuncture implantation wire contains no magnetic material, no hysteresis loop curve test results were obtained. Therefore, for the magnetic properties of single magnetic piezoelectric acupuncture implantation wires, the suitable CoFe2O4 contents are 1, 2, 3, and 4 wt.%.

[0072] Combination Figure 8 and Figure 9 The conclusion is that the optimal range of the ratio of magnetic material to piezoelectric material for preparing single magnetic piezoelectric acupuncture embedding threads, "x", is 2wt.% ≤ x ≤ 4wt.%.

[0073] Comparative Example 1

[0074] On the basis of Example 2, the liquid immersion operation was cancelled, that is, the mixed precursor solution after high-voltage electric field polarization was directly used to draw (wire drawing) with a cylindrical roller support, but a complete wire body could not be drawn out.

[0075] Comparative Example 2

[0076] This comparative example used ordinary 3D printing technology to prepare the wire body, which specifically included the following steps:

[0077] S1. Prepare a suspension of CoFe2O4 and a solution of 16 wt.% polyvinylidene fluoride in N,N-dimethylformamide (magnetic stirring for 12 h);

[0078] S2. Non-magnetically stir the CoFe2O4 suspension and the polyvinylidene fluoride N,N-dimethylformamide solution in S1 for 4 h to prepare a mixed precursor solution;

[0079] S3. Use the mixed precursor solution in an extrusion 3D printing method to prepare a single magnetic piezoelectric acupuncture embedding wire. The diameter of the extrusion 3D printing needle is 0.51 mm, the printing speed is 4 mm / s, the extrusion speed is 3.5 mm 3 / s, and the printing model is set as a concentric "return" type.

[0080] As a result, the "wire body" printed by 3D printing in this comparative example collapsed, and finally a single magnetic piezoelectric acupuncture embedding wire could not be successfully prepared.

[0081] Comparative Example 3

[0082] This comparative example, on the basis of Comparative Example 2, carried out liquid immersion treatment on the mixed precursor solution and then used 3D printing technology to prepare the wire body, which specifically included the following steps:

[0083] S1. Prepare a suspension of CoFe2O4 and a solution of 16 wt.% polyvinylidene fluoride in N,N-dimethylformamide (magnetic stirring for 12 h);

[0084] S2. Non-magnetically stir the CoFe2O4 suspension and the polyvinylidene fluoride N,N-dimethylformamide solution in S1 for 4 h to prepare a mixed precursor solution;

[0085] S3. Use the mixed precursor solution in an extrusion 3D printing method to prepare a single magnetic piezoelectric acupuncture embedding wire. The diameter of the extrusion 3D printing needle is 0.51 mm, the printing speed is 4 mm / s, the extrusion speed is 3.5 mm 3 / s, and the printing model is set as a concentric "return" type. And below the needle of the extrusion 3D printing, a collecting device filled with gellan gum is set, and the printed acupuncture embedding wire is collected in the gellan gum. The temperature of the extrusion 3D printing bottom plate needs to heat the gellan gum and maintain it at 70 °C.

[0086] Figure 10 This comparative example collects extruded 3D printed acupuncture threads. This comparative example initially prepared a material with a rudimentary "thread" shape, but the minimum diameter of this "thread" can only achieve a specification of 1.06 mm ± 0.16 mm. Compared to the single magnetic piezoelectric acupuncture thread with a diameter of 0.17 mm ± 0.014 mm prepared by the technical method of Example 1, and the single magnetic piezoelectric acupuncture thread with a diameter of 0.09 mm ± 0.006 mm prepared by the technical method of Example 2, the diameter of the "thread" in this comparative example is too large and does not meet the basic size requirement of 0.80 mm for the maximum diameter of acupuncture threads.

[0087] It should be understood that the specific embodiments described above are only used to explain the present invention and are not intended to limit the present invention. That is, the described embodiments are only some embodiments of the present invention, and not all embodiments. For example, the piezoelectric polymer substrate material for becoming a single magnetic piezoelectric acupuncture embedding thread is not limited to polyvinylidene fluoride, as long as the material itself can be configured into a polymer precursor liquid at room temperature, such as polylactic acid (PVA), polycaprolactone (PCL), polyvinyl alcohol (PVA), polyvinylidene fluoride (PVDF), and polyethylene glycol (PEG); the magnetic material is not limited to CoFe2O4, but also includes dysprosium iron (Dy-Fe), terbium iron (Tb-Fe), samarium iron (Sm-Fe), and Fe. 100-x Ga x (0 < x < 100), Fe 85 Ga 15-y Al y (0 < y < 15), Fe 80 Ga 20-z Al z (0 < z < 20), Fe 100-m Al m (0 < m < 100), Co n Fe 3-n One or more of the following materials: O4 (0 < n < 3); the liquid used for soaking is not limited to water and gellan gum, but can be any hydrogel material, such as gelatin, collagen, chitosan, polyvinyl alcohol, polyacrylamide, methacrylamide gelatin, methacrylated hyaluronic acid, hydroxyethyl methacrylate, etc.

[0088] The embodiments described above merely illustrate specific implementation methods of this application, and while the descriptions are detailed and specific, they should not be construed as limiting the scope of protection of this application. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the technical solution of this application, and these modifications and improvements all fall within the scope of protection of this application.

Claims

1. A single magnetic piezoelectric acupuncture embedding thread, characterized in that, The single magnetic piezoelectric acupuncture thread is a thread obtained by sequentially polarizing a dispersion of piezoelectric material and magnetic material under a high-voltage electric field, soaking in liquid, drawing out the thread, and drying it. The liquid used in the soaking process is water or a hydrogel material.

2. The single magnetic piezoelectric acupuncture thread as described in claim 1, characterized in that, The piezoelectric material is polyvinylidene fluoride.

3. The single magnetic piezoelectric acupuncture thread as described in claim 2, characterized in that, The magnetic material is CoFe2O4.

4. The single magnetic piezoelectric acupuncture thread as described in claim 3, characterized in that, The mass fraction of CoFe2O4 is 2-4%.

5. The single magnetic piezoelectric acupuncture thread as described in claim 1, characterized in that, The hydrogel material is one or more of the following: gellan gum, gelatin, chitosan, sodium alginate, collagen, hyaluronic acid, chondroitin sulfate, polyacrylamide, polyethylene glycol, polyacrylic acid, polyvinyl alcohol, polyhydroxyethyl methacrylate and its derivatives.

6. The method for preparing a single magnetic piezoelectric acupuncture embedding thread as described in any one of claims 1 to 5, characterized in that, Includes the following steps: (1) Preparation of magnetic material suspension; (2) The piezoelectric material is dispersed in a solvent to form a dispersion; (3) Mix the magnetic material suspension and the piezoelectric material dispersion, and stir non-magnetically for 2-8 hours to obtain the precursor solution; (4) Place the precursor liquid in a high-voltage electric field polarization device with a voltage range of 8 to 22 kV; (5) Under a high voltage electric field, the precursor solution polarized by the high voltage electric field is immersed in water or hydrogel material for 10 minutes. (6) Using one of the following: cylindrical roller bracket, cylindrical roller, circular skeleton roller and circular skeleton roller bracket, a circumferential collection device is first pulled out and hung on the circumferential collection device, and then the circumferential collection device is used to curl and collect the single magnetic piezoelectric acupuncture embedding thread precursor. (7) The collected single magnetic piezoelectric acupuncture embedding thread precursors are kept still for 10-16 hours, and then dried in a forced-air drying oven at a temperature of 50-100℃ for 10-16 hours to obtain the single magnetic piezoelectric acupuncture embedding thread.

7. The method for preparing a single magnetic piezoelectric acupuncture embedding thread as described in claim 6, characterized in that, In step (6), the distance between the circumferential collecting device and the liquid immersion device is 15cm.

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