Water-resistant and salt-resistant dressing and preparation process thereof

Abstract

The invention discloses a water-resistant and salt-resistant dressing, including: a base layer, a water-resistant and salt-resistant layer is provided inside and outside the base layer, and the weight composition of the water-resistant and salt-resistant layer includes: 30-40 parts of acrylic acid, 10-15 parts of anti-sagging agent, 20-35 parts of fibrous talcum powder, 10-15 parts of nano silicon carbide, 5-8 parts of polyester resin, 2-4 parts of butyl acetate, 0.3-0.6 parts of defoamer, 0.3-0.6 parts of leveling agent, 0.8-1 parts of hindered amine, 0.8-1 parts of UV absorber, and 0.5-0.6 parts of organosilane coupling agent. A hemostatic layer is provided in the middle of the base layer, and connecting layers are provided on both sides of the hemostatic layer. The present invention adds acrylic acid, fibrous talcum powder and nano silicon carbide in the process of preparing the product, and through its acid water-resistant and salt-resistant characteristics, the water-resistant and salt-resistant performance of the dressing as a whole is greatly improved, and the use effect in extremely harsh environments such as seawater is improved.

Description

Technical Field

[0001] The invention relates to the technical field of medical supplies, and in particular to a water-resistant and salt-resistant dressing and a preparation process thereof. Background Art

[0002] As the largest organ of the human body, the skin can serve as a strong barrier to prevent serious damage to the human body caused by external pathogenic, microbial, chemical, mechanical and other external factors. When the skin is damaged, the traditional concept is that the healing of the wound surface requires a dry and disinfected wound to achieve subcrustal healing, but the growth factors that promote wound healing can only travel under the scab, and the new granulation tissue is easily damaged, causing the healing process to be repeated. As a substitute for the skin, medical dressings can keep the wound moist and clean, achieve scab-free healing, and moist exudate under the closed dressing, keratinocyte proliferation, protect the new granulation tissue from damage, and growth factors can fully exert their efficacy to promote wound healing. However, wound infection is an important problem that hinders wound healing. The simple water-based polyurethane film cannot meet the water and salt resistance requirements of the prepared medical dressing, resulting in poor performance of the medical dressing and less than expected results. Therefore, we propose a water-resistant and salt-resistant dressing and its preparation process. Summary of the invention

[0003] The main purpose of the present invention is to provide a water-resistant and salt-resistant dressing. The present invention adds acrylic acid, fibrous talcum powder and nano-silicon carbide during the preparation of the product, and through their acid, water and salt resistance, the water and salt resistance of the dressing as a whole is greatly improved, and the use effect in extremely harsh environments such as seawater is improved.

[0004] In order to solve the above technical problems, the present invention discloses a water-resistant and salt-resistant dressing, comprising: a base layer, water-resistant and salt-resistant layers are arranged inside and outside the base layer, a hemostatic layer is arranged in the middle of the base layer, and connecting layers are arranged on both sides of the hemostatic layer.

[0005] According to one embodiment of the present invention, the weight composition of the water-resistant and salt-resistant layer includes: 30-40 parts of acrylic acid, 10-15 parts of anti-sagging agent, 20-35 parts of fibrous talc, 10-15 parts of nano-silicon carbide, 5-8 parts of polyester resin, 2-4 parts of butyl acetate, 0.3-0.6 parts of defoaming agent, 0.3-0.6 parts of leveling agent, 0.8-1 parts of hindered amine, 0.8-1 parts of UV absorber, and 0.5-0.6 parts of organic silane coupling agent.

[0006] According to one embodiment of the present invention, the weight composition of the water-resistant and salt-resistant layer includes: 30 parts of acrylic acid, 10 parts of anti-sagging agent, 20 parts of fibrous talc, 10 parts of nano-silicon carbide, 5 parts of polyester resin, 2 parts of butyl acetate, 0.3 parts of defoaming agent, 0.3 parts of leveling agent, 0.8 parts of hindered amine, 0.8 parts of UV absorber, and 0.5 parts of organic silane coupling agent.

[0007] According to one embodiment of the present invention, the weight composition of the water-resistant and salt-resistant layer includes: 40 parts of acrylic acid, 15 parts of anti-sagging agent, 35 parts of fibrous talc, 15 parts of nano-silicon carbide, 8 parts of polyester resin, 4 parts of butyl acetate, 0.6 parts of defoaming agent, 0.6 parts of leveling agent, 1 part of hindered amine, 1 part of UV absorber, and 0.6 parts of organic silane coupling agent.

[0008] According to one embodiment of the present invention, the weight composition of the water-resistant and salt-resistant layer includes: 35 parts of acrylic acid, 12 parts of anti-sagging agent, 30 parts of fibrous talc, 12 parts of nano-silicon carbide, 6 parts of polyester resin, 3 parts of butyl acetate, 0.5 parts of defoaming agent, 0.5 parts of leveling agent, 0.9 parts of hindered amine, 0.9 parts of UV absorber, and 0.55 parts of organic silane coupling agent.

[0009] According to one embodiment of the present invention, the above-mentioned process for preparing a water-resistant and salt-resistant dressing comprises: Preparation of the base layer: The chitosan raw material is dissolved in a 5% acetic acid aqueous solution, filtered and degassed to form a spinning solution of a certain viscosity, and then extruded from a spinneret through a metering pump. The thin stream of the solution is coagulated into solid fibers in a coagulation bath, and then further stretched to obtain the base layer; Preparation of water-resistant and salt-resistant layer solution: adding acrylic acid, anti-sagging agent, fibrous talc, nano silicon carbide, polyester resin, butyl acetate, defoamer, leveling agent, hindered amine, UV absorber, and organic silane coupling agent to distilled water, heating at 25-100°C and stirring until the precipitate is completely precipitated, washing the precipitate with distilled water until it is neutral, and then heating at 30-80°C to react to obtain a water-resistant and salt-resistant layer solution; (3) Soaking: Immerse the base layer in a water-resistant and salt-resistant solution for 5-10 minutes, take it out and dry it, and bond the hemostatic layer in the middle of the base layer. The hemostatic layer is a hemostatic cloth, and connecting layers are set on both sides of the base layer to obtain the final product.

[0010] Compared with the prior art, the present application can obtain the following technical effects: 1) In the process of preparing the product, acrylic acid is added to greatly improve the water and salt resistance of the dressing as a whole due to the water and salt resistance of acrylic acid, and improve the use effect in extremely harsh environments such as seawater.

[0011] Of course, any product implementing the present invention does not necessarily need to achieve all of the above technical effects at the same time. DETAILED DESCRIPTION

[0012] The following will explain the implementation methods of the present application in detail with reference to examples, so that the implementation process of how the present application uses technical means to solve technical problems and achieve technical effects can be fully understood and implemented accordingly.

[0013] A water-resistant and salt-resistant dressing comprises a base layer, water-resistant and salt-resistant layers are arranged inside and outside the base layer, a hemostatic layer is arranged in the middle of the base layer, and connecting layers are arranged on both sides of the hemostatic layer.

[0014] The water- and salt-resistant layer is arranged outside the base layer of the present invention, which greatly improves the water- and salt-resistant performance of the dressing as a whole and improves the use effect in extremely harsh environments such as seawater. The hemostatic layer is arranged in the middle of the base layer, which greatly enhances the hemostatic ability of the device, and connecting layers are arranged on both sides of the hemostatic layer for connection.

[0015] Preferably, the weight composition of the water-resistant and salt-resistant layer includes: 30-40 parts of acrylic acid, 10-15 parts of anti-sagging agent, 20-35 parts of fibrous talc, 10-15 parts of nano-silicon carbide, 5-8 parts of polyester resin, 2-4 parts of butyl acetate, 0.3-0.6 parts of defoaming agent, 0.3-0.6 parts of leveling agent, 0.8-1 parts of hindered amine, 0.8-1 parts of UV absorber, and 0.5-0.6 parts of organic silane coupling agent.

[0016] Preferably, a process for preparing a water-resistant and salt-resistant dressing comprises: (1) Preparation of base layer: Dissolve chitosan raw material in 5% acetic acid aqueous solution, filter and degas to prepare spinning solution of certain viscosity, and then pass through metering pump and extrude from spinneret. The thin stream of solution is coagulated into solid fiber in coagulation bath, and then further stretched to obtain base layer; (2) Preparation of water-resistant and salt-resistant layer solution: Add acrylic acid, anti-sagging agent, fibrous talcum powder, nano silicon carbide, polyester resin, butyl acetate, defoamer, leveling agent, hindered amine, UV absorber, and organic silane coupling agent into distilled water, heat to 25-100°C and stir, and then completely precipitate out, wash the precipitate with distilled water until neutral, and then heat to 30-80°C to react to obtain water-resistant and salt-resistant layer solution; (3) Soaking: Immerse the base layer in the water-resistant and salt-resistant solution for 5-10 minutes, take it out and dry it, and bond a hemostatic layer in the middle of the base layer. The hemostatic layer is a hemostatic cloth, and connecting layers are set on both sides of the base layer to obtain the final product.

[0017] Therefore, 4 groups of examples with different ratios were carried out according to the above method.

[0018] Example 1: According to the above-mentioned water-resistant and salt-resistant dressing preparation process, the chitosan raw material is dissolved in a 5% acetic acid aqueous solution, filtered and degassed to prepare a spinning solution of a certain viscosity, and then passed through a metering pump and extruded from a spinneret. The thin stream of the solution is coagulated into solid fibers in a coagulation bath, and then further stretched to obtain a dressing.

[0019] Example 2, (1) Preparation of base layer: Dissolve chitosan raw material in 5% acetic acid aqueous solution, filter and degas to prepare spinning solution of certain viscosity, then pass through metering pump and extrude from spinneret, the thin stream of solution is coagulated into solid fiber in coagulation bath, and then further stretched to obtain base layer; (2) Preparation of water-resistant and salt-resistant layer solution: The water-resistant and salt-resistant layer comprises the following components by weight: 30 parts of acrylic acid, 10 parts of anti-sagging agent, 20 parts of fibrous talc, 10 parts of nano silicon carbide, 5 parts of polyester resin, 2 parts of butyl acetate, 0.3 parts of defoaming agent, 0.3 parts of leveling agent, 0.8 parts of hindered amine, and 0.8 parts of UV absorber. 0.5 parts of organic silane coupling agent and 0.5 parts of organic silane coupling agent are added into distilled water, heated at 25-100°C and stirred until the precipitate is completely precipitated, washed with distilled water until the precipitate is neutral, and then heated at 30-80°C to react to obtain a water-resistant and salt-resistant layer solution; (3) Soaking: immerse the base layer in the water-resistant and salt-resistant solution for 5-10 minutes, take it out and dry it, and bond a hemostatic layer in the middle of the base layer, the hemostatic layer is a hemostatic cloth, and connecting layers are set on both sides of the base layer to obtain the final product.

[0020] Example 3 (1) Preparation of base layer: Dissolve chitosan raw material in 5% acetic acid aqueous solution, filter and degas to prepare spinning stock solution of certain viscosity, then pass through a metering pump and extrude from a spinneret, the stock solution in a thin stream is coagulated into solid fiber in a coagulation bath, and then further stretched to obtain the base layer; (2) Preparation of water-resistant and salt-resistant layer solution: The weight composition of the water-resistant and salt-resistant layer includes: 35 parts of acrylic acid, 12 parts of anti-sagging agent, 30 parts of fibrous talc, 12 parts of nano-silicon carbide, 6 parts of polyester resin, 3 parts of butyl acetate, 0.5 parts of defoaming agent, 0.5 parts of leveling agent, 0.9 parts of hindered amine, 0.9 parts of UV absorber, and 0.55 parts of organic silane coupling agent. Add to distilled water, heat at 25-100°C and stir until the precipitate is completely precipitated, wash the precipitate with distilled water until it is neutral, and then heat at 30-80°C to react to obtain a water-resistant and salt-resistant layer solution; (3) Soaking: immerse the base layer in the water-resistant and salt-resistant solution for 5-10 minutes, take it out and dry it, and bond a hemostatic layer in the middle of the base layer. The hemostatic layer is a hemostatic cloth, and connecting layers are set on both sides of the base layer to obtain the final product.

[0021] Example 4 (1) Preparation of base layer: The chitosan raw material is dissolved in a 5% acetic acid aqueous solution, filtered and degassed to form a spinning stock solution of a certain viscosity, and then extruded from a spinneret through a metering pump. The stock solution in a thin stream is coagulated into a solid fiber in a coagulation bath, and then further stretched to obtain a base layer; (2) Preparation of water-resistant and salt-resistant layer solution: The weight composition of the water-resistant and salt-resistant layer includes: 40 parts of acrylic acid, 15 parts of an anti-sagging agent, 35 parts of fibrous talc, 15 parts of nano-silicon carbide, 8 parts of polyester resin, and 4 parts of butyl acetate , 0.6 parts of defoaming agent, 0.6 parts of leveling agent, 1 part of hindered amine, 1 part of UV absorber and 0.6 parts of organic silane coupling agent are added into distilled water and heated at 25-100°C with stirring until the precipitate is completely precipitated, and the precipitate is washed with distilled water until it is neutral, and then heated at 30-80°C to react to obtain a water-resistant and salt-resistant layer solution; (3) Soaking: immerse the base layer in the water-resistant and salt-resistant solution for 5-10 minutes, take it out and dry it, and bond a hemostatic layer in the middle of the base layer. The hemostatic layer is a hemostatic cloth, and connecting layers are set on both sides of the base layer to obtain the final product.

[0022] Then, an artificial accelerated simulated salt spray environment test was carried out, and the overall corrosion conditions of the above embodiments 1-4 were carefully compared and recorded. In summary, the dressing obtained in embodiment 1 has the worst water and salt resistance. Embodiment 3, by adding appropriate proportions of acrylic acid, fibrous talc and nano-silicon carbide, has the best water and salt resistance compared to the dressings obtained in embodiments 2-4, and no obvious corrosion conditions occurred, thereby maximizing the use effect in extremely harsh environments such as seawater.

[0023] The above description shows and describes several preferred embodiments of the present application, but as before, it should be understood that the present application is not limited to the form disclosed herein, and should not be regarded as excluding other embodiments, but can be used in various other combinations, modifications and environments, and can be modified within the scope of the present application through the above teachings or the technology or knowledge of the relevant field. The changes and modifications made by those skilled in the art shall not deviate from the spirit and scope of the present application, and shall be within the scope of protection of the claims attached to the present application.

Claims

1. A water-resistant and salt-resistant dressing, characterized in that: The invention comprises: a base layer, water-resistant and salt-resistant layers are arranged inside and outside the base layer, a hemostatic layer is arranged in the middle of the base layer, and connecting layers are arranged on both sides of the hemostatic layer.

2. The water-resistant and salt-resistant dressing according to claim 1, characterized in that: The weight composition of the water-resistant and salt-resistant layer includes: 30-40 parts of acrylic acid, 10-15 parts of anti-sagging agent, 20-35 parts of fibrous talc, 10-15 parts of nano silicon carbide, 5-8 parts of polyester resin, 2-4 parts of butyl acetate, 0.3-0.6 parts of defoaming agent, 0.3-0.6 parts of leveling agent, 0.8-1 parts of hindered amine, 0.8-1 parts of UV absorber, and 0.5-0.6 parts of organic silane coupling agent.

3. The water-resistant and salt-resistant dressing according to claim 1, characterized in that: The weight composition of the water-resistant and salt-resistant layer includes: 30 parts of acrylic acid, 10 parts of anti-sagging agent, 20 parts of fibrous talc, 10 parts of nano silicon carbide, 5 parts of polyester resin, 2 parts of butyl acetate, 0.3 parts of defoaming agent, 0.3 parts of leveling agent, 0.8 parts of hindered amine, 0.8 parts of UV absorber, and 0.5 parts of organic silane coupling agent.

4. The water-resistant and salt-resistant dressing according to claim 1, characterized in that: The weight composition of the water-resistant and salt-resistant layer includes: 40 parts of acrylic acid, 15 parts of anti-sagging agent, 35 parts of fibrous talc, 15 parts of nano silicon carbide, 8 parts of polyester resin, 4 parts of butyl acetate, 0.6 parts of defoaming agent, 0.6 parts of leveling agent, 1 part of hindered amine, 1 part of UV absorber, and 0.6 parts of organic silane coupling agent.

5. The water-resistant and salt-resistant dressing according to claim 1, characterized in that: The weight composition of the water-resistant and salt-resistant layer includes: 35 parts of acrylic acid, 12 parts of anti-sagging agent, 30 parts of fibrous talc, 12 parts of nano silicon carbide, 6 parts of polyester resin, 3 parts of butyl acetate, 0.5 parts of defoaming agent, 0.5 parts of leveling agent, 0.9 parts of hindered amine, 0.9 parts of UV absorber, and 0.55 parts of organic silane coupling agent.

6. A process for preparing the water-resistant and salt-resistant dressing according to claim 1, characterized in that: include: (1) Preparation of the base layer: The chitosan raw material is dissolved in a 5% acetic acid aqueous solution, filtered and degassed to form a spinning solution of a certain viscosity, which is then extruded from a spinneret through a metering pump. The thin stream of the solution is coagulated into solid fibers in a coagulation bath, and then further stretched to obtain the base layer; (2) Preparing a water-resistant and salt-resistant layer solution: adding acrylic acid, an anti-sagging agent, fibrous talc, nano silicon carbide, polyester resin, butyl acetate, a defoaming agent, a leveling agent, a hindered amine, a UV absorber, and an organic silane coupling agent to distilled water, heating at 25 to 100° C. and stirring until the precipitate is completely precipitated, washing the precipitate with distilled water until it is neutral, and then heating at 30 to 80° C. to react to obtain a water-resistant and salt-resistant layer solution; (3) Soaking: Immerse the base layer in a water-resistant and salt-resistant solution for 5-10 minutes, take it out and dry it, and bond the hemostatic layer in the middle of the base layer. The hemostatic layer is a hemostatic cloth, and connecting layers are set on both sides of the base layer to obtain the final product.