Preparation process of nikeshu salt

Abstract

The invention provides a nikeshu salt preparation process, the nikeshu salt comprises the following components by weight: 40%-55% of nikeshu, 32%-44% of benzoic acid and the balance of propylene glycol, the nikeshu accounts for 40%-55% of the total amount of the nikeshu salt, the benzoic acid accounts for 32%-44% of the total amount of the nikeshu salt, and the rest is supplemented by the propylene glycol; and setting the reaction temperature of the nikeshu, the benzoic acid and the propylene glycol to be 50-70 DEG C. After the Nikeshu salt prepared by the Nikeshu salt preparation process disclosed by the invention is applied to tobacco tar, the taste is good when a user smokes an electronic cigarette, the throat striking feeling is strong, and the irritation is not strong.

Description

Technical Field

[0001] The present invention belongs to the technical field of nicosulphate salts, and more specifically, relates to a process for preparing nicosulphate salts. Background Art

[0003] Currently, there are various methods for developing nicotine salt, and the quality is also uneven. The use of nicotine salt in e-cigarette oil generally has problems such as poor taste and failure to improve the excessive stimulation of nicotine to the throat. Summary of the invention

[0004] The present invention provides a process for preparing nicosulphate salt to solve the technical problems mentioned in the background technology.

[0005] The technical solution adopted by the present invention is a process for producing nicosulphate salts, wherein the components of the nicosulphate salts include nicosulphate, benzoic acid and propylene glycol, wherein, by weight, the proportion of nicosulphate to the total amount of the nicosulphate salts is 40%-55%, the proportion of benzoic acid to the total amount of the nicosulphate salts is 32%-44%, and the remaining substances are supplemented by the propylene glycol; and

[0006] The reaction temperature of the nicotinic acid, benzoic acid and propylene glycol is set to 50° to 70°.

[0007] In the nicosulphate production process of the present application, nicosulphate includes three ingredients, namely nicosulphate, benzoic acid and propylene glycol, wherein by weight, nicosulphate accounts for 40%-55% of the total amount of nicosulphate, benzoic acid accounts for 32%-44% of the total amount of nicosulphate, and the remaining substances are supplemented by propylene glycol, and the reaction temperature of nicosulphate, benzoic acid and propylene glycol is set to 50°~70°. After the nicosulphate prepared by the above process is applied to the e-liquid, the user has a good taste when smoking an electronic cigarette, a strong throat hit, and low irritation.

[0008] As a preferred embodiment of the present invention, the proportion of Nikosu in the total amount is 40%, 45% or 55%.

[0009] As a preferred embodiment of the present invention, the proportion of benzoic acid in the total amount of the nicosulphate salt is 32%, 38%, or 44%.

[0010] As a preferred embodiment of the present invention, the reaction temperature of the nicotinic acid, benzoic acid and propylene glycol is set to 50°, 60° or 70°.

[0011] As a preferred embodiment of the present invention, stirring is performed during the reaction of nicotinic acid, benzoic acid and propylene glycol. Specific embodiments

[0013] It should be noted that when an element is referred to as being "fixed to" or "disposed on" another element, it can be directly on the other element or indirectly on the other element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or indirectly connected to the other element.

[0015] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of some inventions, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0016] The present application provides a process for producing nicosulphate salt, which is used for producing nicosulphate salt.

[0017] The components of Nicosul salt include Nicosul, benzoic acid and propylene glycol. Among them, Nicosul is 6-methyl nicotine, and its molecular formula is C11H16N2. The molecular formula of benzoic acid is C7H6O2. The molecular formula of propylene glycol is C3H8O2.

[0018] Furthermore, the weight of nicosulin, benzoic acid and propylene glycol in the nicosulin salt is such that nicosulin accounts for 40%-55% of the total weight of the nicosulin salt, benzoic acid accounts for 32%-44% of the total weight of the nicosulin salt, and the remaining substances are supplemented by propylene glycol.

[0019] For example, when the proportion of Nicosul in the total amount is 40%, the proportion of benzoic acid in the total amount of Nicosul salt is 32%, and the proportion of propylene glycol in the total amount of Nicosul salt is 28%.

[0020] Furthermore, the reaction temperature of nicotinic acid, benzoic acid and propylene glycol is set to 50° to 70°.

[0021] In the nicosulphate production process of the present application, nicosulphate includes three ingredients, namely nicosulphate, benzoic acid and propylene glycol, wherein by weight, nicosulphate accounts for 40%-55% of the total amount of nicosulphate, benzoic acid accounts for 32%-44% of the total amount of nicosulphate, and the remaining substances are supplemented by propylene glycol, and the reaction temperature of nicosulphate, benzoic acid and propylene glycol is set to 50°-70°. After the nicosulphate prepared by the above process is applied to the e-liquid, the user has a good taste when smoking an electronic cigarette, a strong throat hit, and low irritation.

[0022] In order to obtain the ratio of nicotinic acid, benzoic acid and propylene glycol and the optimal reaction temperature, an experimental scheme is provided in the examples of the present application.

[0023] Scheme 1: Verify the effect of nicotinic acid salt prepared by mixing nicotinic acid, benzoic acid and propylene glycol in the same ratio at different reaction temperatures on the taste and throat hit of the e-liquid.

[0024] In experiment ①, the proportion of nicotinic acid to the total amount of nicotinic acid salt is 40%-55%, the proportion of benzoic acid to the total amount of nicotinic acid salt is 32%-44%, the remaining substances are supplemented by propylene glycol, and the reaction temperature of nicotinic acid, benzoic acid and propylene glycol is set to 30°-50° to prepare nicotinic acid salt. During the process, the reaction rate is slow, and the salt generated is the lightest in color, orange-red, in a liquid state, but relatively viscous.

[0025] In experiment ②, the proportion of nicotinic acid to the total amount of nicotinic acid salt was 40%-55%, the proportion of benzoic acid to the total amount of nicotinic acid salt was 32%-44%, the remaining substances were supplemented by propylene glycol, and the reaction temperature of nicotinic acid, benzoic acid and propylene glycol was set to 50°-70° to prepare nicotinic acid salt. During the process, the reaction rate was fast, and the color of the generated salt was darker, orange-red with a reddish tint, and the viscosity was medium.

[0026] In experiment ③, the proportion of nicosu to the total amount of nicosu salt is 40%-55%, the proportion of benzoic acid to the total amount of nicosu salt is 32%-44%, and the remaining substances are supplemented by propylene glycol, and the reaction temperature of nicosu, benzoic acid and propylene glycol is set to 70°~90° to obtain nicosu salt. During the process, the reaction rate is the fastest, and the color of the generated salt is the darkest, which is red with a brownish red color and a slightly lower viscosity. However, in experiment ③, there are problems such as the reaction temperature is too high, the reactants are highly volatile, and the product color is darker, which is not conducive to subsequent production and storage.

[0027] The nicotinic salts obtained in the above experiments ① to ③ were respectively prepared into electronic cigarette liquids, and 22 smokers were asked to smoke them, and the following table was obtained:

[0028]

[0029] As shown in the above table, sample B has the best taste and flavor, sample C is second, and sample A is the worst. Sample A is the Nicoshu salt of experiment No. ①, sample B is the Nicoshu salt of experiment No. ②, and sample C is the Nicoshu salt of experiment No. ③. Therefore, the Nicoshu salt of experiment No. ② has the best taste and flavor, the Nicoshu salt of experiment No. ③ is second, and the Nicoshu salt of experiment No. ① is the worst.

[0030] That is to say, the nicotinic acid salt prepared by the reaction of nicotinic acid, benzoic acid and propylene glycol at a temperature of 50° to 70° has a good taste and a strong throat hit.

[0031] Scheme 2: Verify the effect of nicotinic acid salt prepared by mixing nicotinic acid, benzoic acid and propylene glycol at the same temperature and in different proportions on the taste and throat hit of the e-liquid.

[0032] Experiment ④, the proportion of nicotinic acid to the total amount of nicotinic acid salt is 20%-30%, the proportion of benzoic acid to the total amount of nicotinic acid salt is 16%-24%, the remaining substances are supplemented by propylene glycol, and the reaction temperature of nicotinic acid, benzoic acid and propylene glycol is set to 50°-70° to prepare nicotinic acid salt. In the process, the reaction rate is faster, the time is shortest, the generated salt is the lightest in color, orange, in liquid state, and has the lowest viscosity.

[0033] Experiment ⑤, the proportion of nicotinic acid to the total amount of nicotinic acid salt is 30%-40%, the proportion of benzoic acid to the total amount of nicotinic acid salt is 24%-32%, the remaining substances are supplemented by propylene glycol, and the reaction temperature of nicotinic acid, benzoic acid and propylene glycol is set to 50°~70° to obtain nicotinic acid salt. During the process, the reaction rate is moderate, the time is moderate, the salt generated is darker in color, orange-red, and has a medium viscosity.

[0034] In experiment ⑥, the proportion of nicotinic acid to the total amount of nicotinic acid salt was 40%-55%, the proportion of benzoic acid to the total amount of nicotinic acid salt was 32%-44%, the remaining substances were supplemented by propylene glycol, and the reaction temperature of nicotinic acid, benzoic acid and propylene glycol was set to 50°-70° to prepare nicotinic acid salt. In the process, the reaction rate was moderate, the time was moderate, the color of the generated salt was darker, orange-red and brown, and the viscosity was slightly higher than the salt in experiment ⑤.

[0035] The nicotinic salts obtained in the above experiments ④ to ⑥ were respectively prepared into electronic cigarette liquids, and 22 smokers were asked to smoke them, and the following table was obtained:

[0036]

[0037]

[0038] As shown in the above table, sample C has the best taste and flavor, sample B is second, and sample A is the worst. Sample A is the Nicoshu salt of experiment No. ④, sample B is the Nicoshu salt of experiment No. ⑤, and sample C is the Nicoshu salt of experiment No. 6. Therefore, the Nicoshu salt of experiment No. 6 has the best taste and flavor, the Nicoshu salt of experiment No. 5 is second, and the Nicoshu salt of experiment No. 4 is the worst.

[0039] That is to say, the ratio of Nicoshub, benzoic acid and propylene glycol is such that Nicoshub accounts for 40%-55% of the total amount of Nicoshub salt, benzoic acid accounts for 32%-44% of the total amount of Nicoshub salt, and the remaining substances are supplemented by propylene glycol. The obtained Nicoshub salt has a good taste and a strong throat hit.

[0040] In summary, when the proportion of nicosulin in the total amount of nicosulin salts is 40%-55%, the proportion of benzoic acid in the total amount of nicosulin salts is 32%-44%, and the remaining substances are supplemented by propylene glycol, and the reaction temperature of nicosulin, benzoic acid and propylene glycol is set to 50°-70°, after the prepared nicosulin salts are applied to the e-liquid, the user has a good taste when smoking an electronic cigarette, a strong throat hit, and not strong irritation.

[0041] Specifically, in some embodiments, the proportion of Nikosulide in the total amount may be 40%, 45% or 55%.

[0042] The proportion of benzoic acid in the total amount of the nicosulite salt is 32%, 38%, or 44%.

[0043] The reaction temperature of nicotinic acid, benzoic acid and propylene glycol can be set to 50°, 60° or 70°.

[0044] In addition, in order to improve the reaction efficiency and allow nicotinic acid, benzoic acid and propylene glycol to react sufficiently, stirring may be performed during the reaction of nicotinic acid, benzoic acid and propylene glycol.

[0045] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of some inventions should be included in the protection scope of some inventions.

Claims

1. A process for producing nicosulphate salt, characterized in that: The components of the nicosulphate salt include nicosulphate, benzoic acid and propylene glycol, wherein, by weight, the nicosulphate accounts for 40%-55% of the total amount of the nicosulphate salt, the benzoic acid accounts for 32%-44% of the total amount of the nicosulphate salt, and the remaining substances are supplemented by the propylene glycol; and The reaction temperature of the nicotinic acid, benzoic acid and propylene glycol is set to 50° to 70°.

2. The process for producing nicosulphate salt according to claim 1, characterized in that: The proportion of Nicosu in the total amount is 40%, 45% or 55%.

3. The process for producing Nicosul salt according to claim 1, characterized in that: The proportion of benzoic acid to the total amount of the nicosulite salt is 32%, 38%, or 44%.

4. The process for producing Nicosul salt according to claim 1, characterized in that: The reaction temperature of the nicotinic acid, benzoic acid and propylene glycol is set to 50°, 60° or 70°.

5. The process for producing Nicosul salt according to any one of claims 1 to 4, characterized in that: Stirring is performed during the reaction of Nicosil, benzoic acid and propylene glycol.

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