A composition for improving the stability of 4-butylresorcinol, its application and an external skin preparation

Abstract

The present invention discloses a composition for improving the stability of 4-butylresorcinol, its application and an external skin preparation, belonging to the technical field of cosmetics. Calculated by weight parts, the composition comprises 0.01 part to 5 parts of 4-butylresorcinol, 0.005 part to 0.195 part of sodium metabisulfite, 0.005 part to 0.195 part of sodium bisulfite, 0.005 part to 3 parts of ergothioneine, and 0.003 part to 0.2 part of troxerutin. The composition can maintain the color of 4-butylresorcinol unchanged for a long time, especially it can still keep the original color under the conditions of ultraviolet irradiation and light irradiation for 3 months. Using the composition to prepare an external skin preparation can enable the external skin preparation to also have better color stability and improve the product quality of the external skin preparation.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and specifically, to a composition for improving the stability of 4-butylresorcinol, its application, and an external skin preparation. Background Art

[0002] With the continuous growth of consumers' demand for whitening products, the pursuit of highly effective and safe whitening ingredients in the cosmetics industry has become increasingly intense. 4-Butylresorcinol occupies an important position in the field of whitening cosmetics due to its unique chemical structure, remarkable whitening effect, and good safety.

[0003] In the field of whitening skin care, the whitening mechanism of 4-butylresorcinol is mainly reflected in inhibiting melanin synthesis, promoting melanin metabolism, and acting in combination with other whitening ingredients.

[0004] Regarding the inhibition of melanin synthesis, 4-butylresorcinol can deeply act on multiple key links in melanin production. In the process of melanin synthesis, tyrosinase plays a crucial role. It catalyzes the oxidation of dopa to dopaquinone, which is then converted into intermediate products such as dopachrome, and finally forms melanin. And 4-butylresorcinol can effectively inhibit the activity of tyrosinase, thereby reducing the production of dopaquinone and subsequent products, fundamentally blocking the melanin synthesis pathway. This inhibitory effect is comprehensive and targeted, making 4-butylresorcinol occupy an important position in whitening skin care products.

[0005] In terms of promoting melanin metabolism, 4-butylresorcinol also shows remarkable effects. It can not only inhibit the generation of new melanin but also accelerate the transfer of the already generated melanin to the stratum corneum. With the metabolism of epidermal cells, these melanins will eventually be excreted from the body, thus achieving the rapid metabolism of melanin. This process is of great significance for improving skin problems such as uneven skin tone and lightening age spots.

[0006] However, 4-butylresorcinol is extremely prone to color change, which has a great impact on products that require color stability.

[0007] In view of this, the present invention is specifically proposed. Summary of the Invention

[0008] The purpose of the present invention is to provide a composition for improving the stability of 4-butylresorcinol, its application, and an external skin preparation to solve or improve the above technical problems.

[0009] The present invention can be achieved as follows:

[0010] In a first aspect, the present invention provides a composition for improving the stability of 4-butylresorcinol. By weight, the composition comprises 0.01 parts to 5 parts of 4-butylresorcinol, 0.005 parts to 0.195 parts of sodium metabisulfite, 0.005 parts to 0.195 parts of sodium bisulfite, 0.005 parts to 3 parts of ergothioneine, and 0.003 parts to 0.2 parts of troxerutin.

[0011] In a second aspect, the present invention provides the use of a composition as described in the foregoing embodiments in the preparation of an external skin preparation.

[0012] In a third aspect, the present invention provides an external skin preparation, and the raw materials for preparing the external skin preparation include the composition of the foregoing embodiments.

[0013] In an optional embodiment, the external skin preparation includes cosmetics.

[0014] In an optional embodiment, the dosage form of the cosmetics includes any one of aqueous solutions, emulsions, sprays, creams, essences, and facial masks.

[0015] In an optional embodiment, by mass percentage, the cosmetics contain 0.01% to 5% of 4-butylresorcinol, 0.005% to 0.195% of sodium metabisulfite, 0.005% to 0.195% of sodium bisulfite, 0.005% to 3% of ergothioneine, and 0.003% to 0.2% of troxerutin.

[0016] In an optional embodiment, the cosmetics are a facial cream, and the raw materials for preparing the facial cream further include auxiliary materials; the auxiliary materials include at least one of preservatives, thickeners, moisturizers, emulsifiers, emollients, and skin conditioners.

[0017] In an optional embodiment, by mass percentage, the content of the preservative in the raw materials for preparing the facial cream is 0.05% to 7%; and / or, the content of the thickener in the raw materials for preparing the facial cream is 0.05% to 2%; and / or, the content of the moisturizer in the raw materials for preparing the facial cream is 1% to 15%; and / or, the content of the emulsifier in the raw materials for preparing the facial cream is 0.5% to 6.5%; and / or, the content of the emollient in the raw materials for preparing the facial cream is 1% to 10%; and / or, the content of the skin conditioner in the raw materials for preparing the facial cream is 0.1% to 5%.

[0018] In an optional embodiment, the preservatives include at least one of pentylene glycol, 1,2-hexanediol, p-hydroxyacetophenone, octyldecanol, ethylhexylglycerin, chlorphenesin, and phenoxyethanol;

[0019] And / or, the thickener includes at least one of carbomer, xanthan gum, cellulose, acrylate / C10-30 alkyl acrylate cross-linked polymer, acryloyldimethyltaurine ammonium / VP copolymer, sodium acrylate / sodium acryloyldimethyltaurate, and hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer;

[0020] And / or, the humectant includes at least one of glycerol, butanediol, 1,3-propanediol, dipropylene glycol, xylitol, and glycerol polyether-26;

[0021] And / or, the emulsifier includes at least one of sodium stearoyl lactylate, higher alcohols, glyceryl stearate, sorbitan laurate, and glyceryl oleate citrate;

[0022] And / or, the emollient includes at least one of polydimethylsiloxane, butanediol dicaprylate / dicaprate, isononyl isononanoate, squalane, and caprylic / capric triglyceride;

[0023] And / or, the skin conditioner includes at least one of panthenol, ectoine, bisabolol, niacinamide, brassinosteroids, and yeast fermentation extract.

[0024] In an alternative embodiment, by mass percentage, the raw materials for preparing the cream include 0.01% - 5% of 4-butylresorcinol, 0.005% - 0.195% of sodium metabisulfite, 0.005% - 0.195% of sodium bisulfite, 0.005% - 3% of ergothioneine, 0.003% - 0.2% of troxerutin, 7% - 8% of butanediol, 0.08% - 0.12% of xanthan gum, 0.45% - 0.55% of acryloyldimethyltaurine ammonium / VP copolymer, 4.5% - 5.5% of pentanediol, 0.45% - 0.55% of 1,2-hexanediol, 1.9% - 2.0% of glyceryl stearate, 0.25% - 0.35% of sodium stearoyl lactylate, 3.5% - 4.0% of cetearyl alcohol, 5.5% - 6.5% of butanediol dicaprylate / dicaprate, and 2.5% - 3.5% of polydimethylsiloxane, with the balance being a solvent.

[0025] In an alternative embodiment, the solvent includes at least one of polyhydric alcohols and water.

[0026] In an alternative embodiment, the polyhydric alcohol includes at least one of glycerol, butanediol, and propylene glycol.

[0027] In an alternative embodiment, the method for preparing the cream includes:

[0028] Mix glyceryl stearate, sodium stearoyl lactylate, cetearyl alcohol, butanediol dicaprylate / dicaprate, and polydimethylsiloxane at 80°C to 90°C for 8 min to 15 min to obtain Phase A;

[0029] Mix xanthan gum, acryloyldimethyltaurate / VP copolymer with butanediol, then add pentylene glycol, 1,2 - hexanediol, and water, and mix at 85°C to 95°C for 25 min to 35 min to obtain Phase B;

[0030] Add Phase A to Phase B and homogenize at 6500 r / min to 7500 r / min for 4 min to 6 min;

[0031] After cooling to 35°C to 40°C, add the composition composed of 4 - butylresorcinol, sodium metabisulfite, sodium bisulfite, ergothioneine, and troxerutin, and stir evenly.

[0032] The beneficial effects of the present invention include:

[0033] In the combination provided by the present invention, sodium metabisulfite, sodium bisulfite, and ergothioneine are mainly used for antioxidant effects. Troxerutin can not only play an antioxidant role but also act as a photoprotectant. The present invention creatively proposes a composition obtained by compounding specific components in a specific ratio, which can have a good color stability effect on 4 - butylresorcinol, especially improving the color stability of 4 - butylresorcinol under long - term ultraviolet irradiation and light irradiation.

[0034] The external skin preparation containing the above composition can have good color stability within a relatively long time range, which is beneficial to improving the product quality of the external skin preparation. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following will briefly introduce the drawings required for the embodiments. It should be understood that the following drawings only show some embodiments of the present invention, so they should not be regarded as limiting the scope. For those of ordinary skill in the art, without creative efforts, other relevant drawings can also be obtained based on these drawings.

[0036] Figure 1 It is a result diagram corresponding to 90 d after the color stability test of the cream samples corresponding to Application Examples 1 - 5 in Test Example 2;

[0037] Figure 2 It is a result diagram corresponding to 90 d after the color stability test of the cream samples corresponding to Application Examples 6 - 10 in Test Example 2;

[0038] Figure 3The figure corresponding to 90d after the color stability test of the cream samples corresponding to Application Examples 11 to 15 in Test Example 2;

[0039] Figure 4 The figure corresponding to 90d after the color stability test of the cream samples corresponding to Application Examples 16 to 20 in Test Example 2. Detailed implementation mode

[0040] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. For those not specified in the embodiments, they are carried out according to conventional conditions or conditions recommended by the manufacturer. For reagents or instruments without indicating the manufacturer, they are all conventional products that can be obtained through commercial purchase.

[0041] The following specifically describes the composition for improving the stability of 4 - butylresorcinol, its application, and the topical skin preparation provided by the present invention.

[0042] The present invention provides a composition for improving the stability of 4 - butylresorcinol. By weight, the composition includes 0.01 parts to 5 parts of 4 - butylresorcinol, 0.005 parts to 0.195 parts of sodium metabisulfite, 0.005 parts to 0.195 parts of sodium bisulfite, 0.005 parts to 3 parts of ergothioneine, and 0.003 parts to 0.2 parts of troxerutin.

[0043] Among them, the dosage of 4 - butylresorcinol can be 0.01 part, 0.05 part, 0.1 part, 0.5 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, or 5 parts, etc., or other values within the range of 0.01 part to 5 parts.

[0044] The dosage of sodium metabisulfite can be 0.005 part, 0.01 part, 0.05 part, 0.1 part, 0.15 part, or 0.195 part, etc., or other values within the range of 0.005 part to 0.195 part.

[0045] The dosage of sodium bisulfite can be 0.005 part, 0.01 part, 0.05 part, 0.1 part, 0.15 part, or 0.195 part, etc., or other values within the range of 0.005 part to 0.195 part.

[0046] The dosage of ergothioneine can be 0.005 part, 0.01 part, 0.05 part, 0.1 part, 0.5 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, or 3 parts, etc., or other values within the range of 0.005 part to 3 parts.

[0047] The dosage of troxerutin can be 0.003 parts, 0.005 parts, 0.01 parts, 0.05 parts, 0.1 parts, 0.15 parts or 0.2 parts, etc., or other values within the range of 0.003 parts to 0.2 parts.

[0048] By combining 4-butylresorcinol, sodium pyrosulfite, sodium bisulfite, ergothioneine and troxerutin according to the above preferred ratio, 4-butylresorcinol can have better color stability.

[0049] In the present invention, sodium pyrosulfite, sodium bisulfite and ergothioneine are mainly used to play an antioxidant role. Troxerutin can play an antioxidant role and also play a role of a light protectant.

[0050] It should be noted that not all antioxidants and light protectants can have a good color stabilization effect on 4-butylresorcinol, especially under the conditions of ultraviolet irradiation and light irradiation for 3 months, the original color can still be maintained. The component selection and ratio relationship of the composition provided by the present invention are obtained after the inventors have made creative efforts. By compounding the above five components according to the above proportions, the discoloration of 4-butylresorcinol due to oxidation to generate aldehyde-like substances can be avoided, and the color stability of 4-butylresorcinol under long-term ultraviolet irradiation and light irradiation can also be improved.

[0051] Correspondingly, the present invention also provides a method for preparing the above-mentioned composition. Specifically, 4-butylresorcinol, sodium pyrosulfite, sodium bisulfite, ergothioneine and troxerutin are mixed according to a preset ratio.

[0052] In addition, the present invention also provides the use of the composition in preparing external skin preparations.

[0053] Accordingly, the present invention also provides an external skin preparation, the raw materials for preparing the external skin preparation include the above composition.

[0054] The above-mentioned external skin preparations may include cosmetics (such as makeup products and facial care products), and may also include body care products and cleaning products, etc.

[0055] The dosage forms of cosmetics may illustratively but not limitatively include aqueous solutions, emulsions, sprays, creams, essences, and facial masks.

[0056] When the external skin preparation is a cosmetic, the cosmetic may contain, calculated by mass percentage, 0.01%~5% of 4-butylresorcinol, 0.005%~0.195% of sodium metabisulfite, 0.005%~0.195% of sodium bisulfite, 0.005%~3% of ergothioneine and 0.003%~0.2% of troxerutin.

[0057] It should be noted that due to the defect that 4-butylresorcinol is prone to discoloration, the addition amount of 4-butylresorcinol in cosmetics is usually low. However, the composition provided by the present invention can effectively maintain good color stability of the product and avoid product discoloration under the condition that the addition amount of 4-butylresorcinol reaches more than 2% (such as 2% - 5%).

[0058] In some optional embodiments, taking the cream as an example of cosmetics, the raw materials for preparing the cream, in addition to the above composition, further include auxiliary materials.

[0059] The auxiliary materials may exemplarily but non - limitatively include at least one of preservatives, thickeners, humectants, emulsifiers, emollients and skin conditioners. In addition, other auxiliary materials available in the art may be added according to actual needs.

[0060] In some optional embodiments, in terms of mass percentage, the content of the preservative in the raw materials for preparing the cream can be 0.05% - 7%, such as 0.05%, 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6% or 7%, etc. The content of the thickener in the raw materials for preparing the cream can be 0.05% - 2%, such as 0.05%, 0.1%, 0.5%, 1%, 1.5% or 2%, etc. The content of the humectant in the raw materials for preparing the cream can be 1% - 15%, such as 1%, 2%, 5%, 8%, 10%, 12% or 15%, etc. The content of the emulsifier in the raw materials for preparing the cream can be 0.5% - 6.5%, such as 0.5%, 1%, 2%, 3%, 4%, 5%, 6% or 6.5%, etc. The content of the emollient in the raw materials for preparing the cream can be 1% - 10%, such as 1%, 2%, 5%, 8% or 10%, etc. The content of the skin conditioner in the raw materials for preparing the cream can be 0.1% - 5%, such as 0.1%, 0.5%, 1%, 2%, 3%, 4% or 5%, etc.

[0061] As an example, the preservative may exemplarily but non - limitatively include at least one of pentylene glycol, 1,2 - hexanediol, p - hydroxyacetophenone, octyldecanol, ethylhexylglycerin, chlorphenesin and phenoxyethanol.

[0062] The thickener may exemplarily but non - limitatively include at least one of carbomer, xanthan gum, cellulose, acrylate / C10 - 30 alkyl acrylate cross - polymer, acryloyldimethyltaurine / VP copolymer, sodium acrylate / sodium acryloyldimethyltaurate and sodium acryloyldimethyltaurate / sodium hydroxyethyl acrylate copolymer.

[0063] The humectant may exemplarily but non - limitatively include at least one of glycerol, butanediol, 1,3 - propanediol, dipropylene glycol, xylitol and glycerol polyether - 26.

[0064] Emulsifiers may include, by way of example but not limitation, at least one of sodium stearoyl lactylate, higher alcohols, glyceryl stearate, sorbitan laurate, and glyceryl oleate citrate.

[0065] Emollients may include, by way of example but not limitation, at least one of polydimethylsiloxane, butylene glycol dicaprylate / dicaprate, isononyl isononanoate, squalane, and caprylic / capric triglyceride.

[0066] Skin conditioners may include, by way of example but not limitation, at least one of panthenol, ectoin, bisabolol, niacinamide, brassinosteroids, and yeast fermentation extract.

[0067] In some relatively typical embodiments, by mass percentage, the raw materials for preparing the facial cream may include 0.01% to 5% (such as 0.01%, 1%, 2%, 3%, 4%, 5%, etc.) of 4-butylresorcinol, 0.005% to 0.195% (such as 0.005%, 0.05%, 0.06%, 0.1%, or 0.195%, etc.) of sodium metabisulfite, 0.005% to 0.195% (such as 0.005%, 0.03%, 0.08%, 0.1%, or 0.195%, etc.) of sodium bisulfite, 0.005% to 3% (such as 0.005%, 0.04%, 0.1%, 0.22%, or 3%, etc.) of ergothioneine, 0.003% to 0.2% (such as 0.003%, 0.05%, 0.16%, 0.1%, or 0.2%, etc.) of troxerutin, 7% to 8% (such as 7%, 7.5%, or 8%, etc.) of butylene glycol, 0.08% to 0.12% (such as 0.08%, 0.09%, 0.1%, 0.11%, or 0.12%, etc.) of xanthan gum, 0.45% to 0.55% (such as 0.45%, 0.48%, 0.50%, 0.52%, or 0.55%, etc.) of acryloyldimethyltaurate / VP copolymer, 4.5% to 5.5% (such as 4.5%, 4.8%, 5.0%, 5.2%, or 5.5%, etc.) of pentylene glycol, 0.45% to 0.55% (such as 0.45%, 0.48%, 0.50%, 0.52%, or 0.55%, etc.) of 1,2-hexanediol, 1.9% to 2.0% (such as 1.9%, 1.95%, or 2.0%, etc.) of glyceryl stearate, 0.25% to 0.35% (0.25%, 0.28%, 0.30%, 0.32%, or 0.35%, etc.) of sodium stearoyl lactylate, 3.5% to 4.0% (such as 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, or 4.0%, etc.) of cetearyl alcohol, 5.5% to 6.5% (such as 5.5%, 5.8%, 6.0%, 6.2%, or 6.5%, etc.) of butylene glycol dicaprylate / dicaprate, 2.5% to 3.5% (such as 2.5%, 2.8%, 3.0%, 3.2%, or 3.5%, etc.) of polydimethylsiloxane, and 4% to 4.5% (such as 4%, 4.1%, 4.2%, 4.3%, 4.4%, or 4.5%, etc.) of the composition, with the balance being the solvent.

[0068] The above solvent may exemplarily but non-limitingly include at least one of polyols and water. Among them, the polyols may further include at least one of glycerol, butylene glycol, and propylene glycol.

[0069] In some more typical embodiments, the raw materials for preparing the facial cream include, by mass percentage, 2% 4-butylresorcinol, 0.1% sodium metabisulfite, 0.1% sodium bisulfite, 0.1% ergothioneine, 0.1% troxerutin, 8% butylene glycol, 0.10% xanthan gum, 0.50% ammonium acryloyldimethyltaurate / VP copolymer, 5.0% pentylene glycol, 0.50% 1,2-hexanediol, 1.95% glyceryl stearate, 0.30% sodium stearoyl lactylate, 3.8% cetearyl alcohol, 6.0% butylene glycol dicaprylate / dicaprate, 3.0% polydimethylsiloxane and 4.5% of the composition, and the balance is water.

[0070] In some optional embodiments, the method for preparing the facial cream comprises:

[0071] S1: According to the proportion, glyceryl stearate, sodium stearoyl lactylate, cetearyl alcohol, butylene glycol dicaprylate / dicaprate and polydimethylsiloxane are mixed at 80°C to 90°C (such as 80°C, 82°C, 85°C, 88°C or 90°C, etc.) for 8min to 15min to obtain phase A;

[0072] S2: xanthan gum, ammonium acryloyldimethyltaurate / VP copolymer and butanediol are mixed according to the proportion, and then pentanediol, 1,2-hexanediol and water are added, and mixed at 85°C to 95°C (such as 85°C, 88°C, 90°C, 92°C or 95°C, etc.) for 25min to 35min (such as 25min, 28min, 30min, 32min or 35min, etc.) to obtain phase B;

[0073] S3: Add phase A to phase B and homogenize at 6500 r / min~7500 r / min (such as 6500 r / min, 6800 r / min, 7000 r / min, 7200 r / min or 7500 r / min, etc.) for 4 min~6 min (such as 4 min, 5 min or 6 min, etc.);

[0074] S4: After cooling to 35°C~40°C (such as 35°C, 38°C or 40°C, etc.), add the composition and stir evenly.

[0075] The features and performance of the present invention are further described in detail below in conjunction with the embodiments.

[0076] Example 1

[0077] This embodiment provides a composition, which includes, by weight, 2 parts of 4-butylresorcinol, 0.1 parts of sodium pyrosulfite, 0.1 parts of sodium bisulfite, 0.1 parts of ergothioneine and 0.1 parts of troxerutin.

[0078] Examples 2 - 5

[0079] The differences between Examples 2 - 5 and Example 1 are only in the component ratios of the composition. For details, please refer to Table 1.

[0080] Comparative Examples 1 - 11

[0081] The differences between Comparative Examples 1 - 11 and Example 1 are only in the component ratios of the composition. For details, please refer to Table 1.

[0082] Comparative Example 12

[0083] The difference between this comparative example and Example 1 is that tocopherol is used to replace ergothioneine in equal amount.

[0084] Comparative Example 13

[0085] The difference between this comparative example and Example 1 is that benzophenone - 4 is used to replace troxerutin in equal amount.

[0086] Comparative Example 14

[0087] The difference between this comparative example and Example 1 is that butylated hydroxytoluene is used to replace sodium metabisulfite in equal amount.

[0088] Comparative Example 15

[0089] The difference between this comparative example and Example 1 is that glutathione is used to replace sodium bisulfite in equal amount.

[0090] Table 1 Component Ratio Table

[0091]

[0092] Application Example 1

[0093] This application example provides a facial cream. By mass percentage, the raw materials for preparing the facial cream include 2% of 4 - butylresorcinol, 0.1% of sodium metabisulfite, 0.1% of sodium bisulfite, 0.1% of ergothioneine, 0.1% of troxerutin (i.e., the composition provided in Example 1), 8% of butanediol, 0.10% of xanthan gum, 0.50% of acryloyldimethyltaurate / VP copolymer, 5.0% of pentylene glycol, 0.50% of 1,2 - hexanediol, 1.95% of glyceryl stearate, 0.30% of sodium stearoyl lactylate, 3.8% of cetearyl alcohol, 6.0% of butanediol dicaprylate / dicaprate, and 3.0% of polydimethylsiloxane, with the balance being water.

[0094] The preparation of the facial cream includes:

[0095] S1: Mix glyceryl stearate, sodium stearoyl lactylate, cetearyl alcohol, butanediol dicaprylate / dicaprate, and polydimethylsiloxane at 85 °C for 10 min to obtain Phase A;

[0096] S2: Mix xanthan gum, acryloyldimethyltaurate / VP copolymer, and butanediol according to the ratio. Then add pentylene glycol, 1,2 - hexanediol, and water, and mix at 90 °C for 30 min to obtain Phase B;

[0097] S3: Add Phase A to Phase B and homogenize at 7000 r / min for 5 min;

[0098] S4: After cooling to 40 °C, add the composition of Example 1 and stir evenly.

[0099] Application Examples 2 - 20

[0100] The differences between Application Examples 2 - 20 and Application Example 1 are only that the compositions in the application examples are successively replaced with the compositions provided in Examples 2 - 5 and Comparative Examples 1 - 15.

[0101] Test Example 1

[0102] Perform color stability tests on the compositions provided in Examples 1 - 5 and Comparative Examples 1 - 15.

[0103] Test conditions: Conduct ultraviolet lamp irradiation and LED lamp irradiation simultaneously in the Binder KBF720 LQC light - irradiated constant temperature and humidity chamber system. The illuminance of the ultraviolet lamp is 0.9 W·hr / m 2 per hour, and the illuminance of the LED lamp is 7000 LUX·hr per hour. Under non - light - protected conditions, conduct a 3 - month (90 - day) stability test.

[0104] After the test, take out the products for color comparison, and the results are shown in Table 2.

[0105] Table 2 Test Results

[0106]

[0107] Note: * Grade 1: No color change; ** Grade 2: Slight pink or slight yellow, not obvious; *** Pink or yellow, obvious; **** Pink, relatively obvious; ***** Pink - yellow, very obvious.

[0108] It can be seen from Table 2 that the compositions provided in the examples of the present invention have higher color stability than the compositions provided in the comparative examples.

[0109] It can be seen by comparing Example 1 with Comparative Examples 2 to 5 that under the condition of the same content of 4-butylresorcinol and cosolvent, there is a certain synergistic effect among sodium metabisulfite, sodium bisulfite, ergothioneine and troxerutin.

[0110] It can be seen by comparing Example 1 with Comparative Examples 6 to 11 that even if 4-butylresorcinol, sodium metabisulfite, sodium bisulfite, ergothioneine and troxerutin are compounded, it is difficult to make 4-butylresorcinol have better color stability if the dosage of any one of sodium metabisulfite, sodium bisulfite, ergothioneine and troxerutin is improper.

[0111] It can be seen by comparing Example 1 with Comparative Examples 12 to 15 that it is also difficult to ensure that 4-butylresorcinol has better color stability by replacing any one of sodium metabisulfite, sodium bisulfite, ergothioneine and troxerutin with other antioxidants.

[0112] Test Example 2

[0113] The color stability tests were carried out on the creams provided in Application Examples 1 to 20.

[0114] Test conditions: Ultraviolet lamp irradiation and LED lamp irradiation were carried out simultaneously in a Binder KBF720 LQC light, temperature and humidity chamber system. The illuminance of the ultraviolet lamp was 0.9 W·hr / m per hour 2 , and the illuminance of the LED lamp was 7000 LUX·hr per hour. Under non-light-shielding conditions, a stability test was carried out for 3 months (90 days).

[0115] Test instrument: A KONICA MINOLTA device (CM-26d) was used to measure color data.

[0116] Test method: Each composition sample was respectively contained in a plurality of sample bottles and loaded into the CM-26d measurement port, and the values at different storage stages were tested. According to the measurement procedures specified in the relevant instrument menu and computer software, the colors (a*, b* and L*) were measured and calculated to generate the color change data (ΔE) value. As a reference, when the value of ΔE is about 3, it is the threshold of the color change of the original sample that can be detected by people through vision.

[0117] The test results are shown in Table 3. Generally speaking, a ΔE value ≤ 3 is acceptable, a ΔE value between 3.5 and 5 is negotiable, and a ΔE value > 5 is unacceptable.

[0118] The test results are shown in Table 3 and Figures 1 to 4 as follows.

[0119] Table 3 Test Results

[0120]

[0121] As can be seen from Table 2, the cream prepared from the composition provided in Examples 1 to 5 of the present invention has significantly better color stability than the cream prepared from the composition provided in Comparative Examples 2 to 15.

[0122] Among Application Examples 1 to 5, the effect of Application Example 1 is the best.

[0123] In summary, the composition provided by the present invention can maintain the color of 4-butylresorcinol unchanged for a long time, especially it can still maintain the original color under the conditions of ultraviolet irradiation and light irradiation for 3 months. When this composition is used to prepare an external skin preparation, the external skin preparation can also have better color stability, thereby improving the product quality of the external skin preparation.

[0124] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. For those skilled in the art, the present invention can have various changes and modifications. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. A cosmetic, characterized in that, By mass percentage, the cosmetic contains 0.01% to 5% of 4-butylresorcinol, 0.005% to 0.195% of sodium metabisulfite, 0.005% to 0.195% of sodium bisulfite, 0.005% to 3% of ergothioneine, and 0.003% to 0.2% of troxerutin.

2. The cosmetic according to claim 1, characterized in that, The cosmetic is a cream, and the preparation raw materials of the cream further include auxiliary materials; the auxiliary materials include at least one of preservatives, thickeners, humectants, emulsifiers, emollients, and skin conditioners.

3. The cosmetic according to claim 2, characterized in that, By mass percentage, the content of the preservative in the preparation raw materials of the cream is 0.05% to 7%; and / or, the content of the thickener in the preparation raw materials of the cream is 0.05% to 2%; and / or, the content of the humectant in the preparation raw materials of the cream is 1% to 15%; and / or, the content of the emulsifier in the preparation raw materials of the cream is 0.5% to 6.5%; and / or, the content of the emollient in the preparation raw materials of the cream is 1% to 10%; and / or, the content of the skin conditioner in the preparation raw materials of the cream is 0.1% to 5%.

4. The cosmetic according to claim 2 or 3, characterized in that, The preservative includes at least one of pentylene glycol, 1,2-hexanediol, p-hydroxyacetophenone, caprylyl glycol, ethylhexylglycerin, chlorphenesin, and phenoxyethanol; and / or, the thickener includes at least one of carbomer, xanthan gum, cellulose, acrylate / C10-30 alkyl acrylate cross-polymer, acryloyldimethyltaurate / VP copolymer, sodium acrylate / sodium acryloyldimethyltaurate, and sodium acryloyldimethyltaurate / sodium hydroxyethyl acrylate copolymer; and / or, the humectant includes at least one of glycerol, butanediol, 1,3-propanediol, dipropylene glycol, xylitol, and glycerol polyether-26; and / or, the emulsifier includes at least one of sodium stearoyl lactylate, higher alcohols, glyceryl stearate, sorbitan laurate, and glyceryl oleate citrate; and / or, the emollient includes at least one of polydimethylsiloxane, butanediol dicaprylate / dicaprate, isononyl isononanoate, squalane, and caprylic / capric triglyceride; and / or, the skin conditioner includes at least one of panthenol, ectoine, bisabolol, niacinamide, brassinosteroids, and yeast fermentation extract.

5. The cosmetic according to claim 4, characterized in that, By mass percentage, the raw materials for preparing the cream include 0.01% - 5% of 4 - butylresorcinol, 0.005% - 0.195% of sodium metabisulfite, 0.005% - 0.195% of sodium bisulfite, 0.005% - 3% of ergothioneine, 0.003% - 0.2% of troxerutin, 7% - 8% of butanediol, 0.08% - 0.12% of xanthan gum, 0.45% - 0.55% of acryloyldimethyltaurate / VP copolymer, 4.5% - 5.5% of pentylene glycol, 0.45% - 0.55% of 1,2 - hexanediol, 1.9% - 2.0% of glyceryl stearate, 0.25% - 0.35% of sodium stearoyl lactylate, 3.5% - 4.0% of cetearyl alcohol, 5.5% - 6.5% of butanediol dicaprylate / dicaprate, and 2.5% - 3.5% of polydimethylsiloxane, with the balance being solvent.

6. The cosmetic according to claim 5, characterized in that, The method for preparing the cream includes: Mix the glyceryl stearate, sodium stearoyl lactylate, cetearyl alcohol, butanediol dicaprylate / dicaprate, and polydimethylsiloxane at 80°C - 90°C for 8 min - 15 min according to the ratio to obtain Phase A; Mix the xanthan gum, acryloyldimethyltaurate / VP copolymer with butanediol according to the ratio, then add pentylene glycol, 1,2 - hexanediol and water, and mix at 85°C - 95°C for 25 min - 35 min to obtain Phase B; Add Phase A to Phase B and homogenize at 6500 r / min - 7500 r / min for 4 min - 6 min; After cooling to 35°C - 40°C, add the composition composed of 4 - butylresorcinol, sodium metabisulfite, sodium bisulfite, ergothioneine and troxerutin, and stir evenly.

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