47 results about "Topical skin agent" patented technology

To provide a topical skin preparation that effectively promotes collagen production within the skin, exhibits excellent usability, and effectively enhances post-use stratum corneum moisture content.SOLUTION: A topical skin preparation comprises niacinamide, a heparin-like substance, dipotassium glycyrrhizinate, a collagen peptide, a yeast extract, and glycylglycine. It is preferable that the topical skin preparation further contains hydrogenated soybean phospholipids and phytosterols. It is more preferable that the topical skin preparation has a niacinamide content of 5 mass% or more. It is also preferable that the topical skin preparation further contains at least one plant extract selected from Arnica montana and Plantago major.SELECTED DRAWING: Figure 1

This invention provides novel stem cell activators, topical skin agents containing the aforementioned stem cell activators, and skin cosmetics containing the aforementioned stem cell activators. The stem cell activator of this invention comprises at least one compound selected from compounds (including optically active agents) shown in formula (1), salts of the aforementioned compounds, and hydrates thereof as active ingredients. In the following formula, R... 1 R 2 Represents a hydrogen atom or a hydrocarbon group. R 3 Represents a hydrogen atom or an organic group. n represents an integer greater than or equal to 1. The above hydrocarbon groups may have substituents. [Chemical Formula 1]

To provide a kit for obtaining a foaming topical skin preparation that improves skin condition and has a pleasant feel. [Solution] The present invention provides a kit for obtaining a foaming topical skin preparation, which is obtained by mixing an acidic substance, a carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, a thickener, and water, and is characterized by the incorporation of two or more thickeners in combination.

To provide a topical skin preparation containing loxoprofen and 60% by mass or more of lower alcohol based on the total amount of the topical skin preparation, with improved storage stability. [Solution] A topical skin preparation containing loxoprofen or a salt thereof, and one or more pH adjusting agents selected from hydrochloric acid or malic acid and their salts, at a concentration of 60% by mass or more based on the total amount of the topical skin preparation.

According to one embodiment, a melanin production inhibitor comprising a compound represented by formula (I) or a salt thereof is provided: [In formula (I), R represents an alkyl group having 1 to 4 carbon atoms].

The present invention relates to a dermatological composition for external application, containing, as an active ingredient, a complex ingredient comprising betulin, a ceramide, a soybean extract, and a green tea seed extract. The dermatological composition for external application has the effects of improving the skin barrier by activating keratinocyte proliferation, enhancing the moisture retention of the skin by reducing transepidermal water loss, and improving acne by inhibiting the lipase activity of Cutibacterium acnes.

This invention provides the application of a cyclic dipeptide in inhibiting the TRPV1 protein, wherein the cyclic dipeptide is a cyclic (D-leucine-L-proline) dipeptide. This invention also relates to the application of the cyclic dipeptide in the preparation of topical skin agents or pharmaceuticals with TRPV1 protein inhibitory activity, wherein the topical skin agent is selected from: creams, lotions, gels, toners, serums, masks, eye creams, aerosol cleansing foams, sprays, shower gels, or facial cleansers.

The present invention provides a collagen production promoter and a topical skin preparation containing the same. [Solution] According to one embodiment, a collagen production promoter comprising a compound represented by formula (I) or a salt thereof is provided: TIFF2026087505000015.tif31163 [In formula (I), R represents an alkyl group having 1 to 4 carbon atoms.]

To provide a topical skin preparation that has excellent effects in preventing and improving wrinkles, anti-aging, anti-inflammatory, pore tightening, whitening, and improving firmness and elasticity, while reducing skin stickiness and being easily absorbed by the skin. [Solution] A topical skin preparation containing specific plant materials, niacin, and glycyrrhizic acid.

The present invention relates to: a cosmetic composition and topical preparation for skin containing an oat ferment filtrate and having skin whitening, elasticity and pore improvement, skin inflammation relief, and hair improvement activities; and use thereof. In particular, the present invention is characterized by a ferment filtrate produced by a proprietary oat koji production with full koji infiltration and multi-stage continuous fermentation method, and uses a composite fermentation technique that combines main fermentation and post-fermentation unlike conventional single fermentation methods. The cosmetic composition of the present invention was proven to be highly effective in skin moisturization, whitening, wrinkle improvement, pore reduction, and the like in clinical trials, and in particular, exhibited greater improvement in all evaluated areas compared to existing fermented cosmetics.

This skin barrier function improving agent contains cytidylic acid or a precursor thereof as an active ingredient.

To provide a topical skin composition that has moderate viscosity while exhibiting excellent stability over time. [Solution] A composition for topical use on the skin, comprising the following components (A) to (F): (A) a polyglycerin fatty acid ester in which R in the fatty acid-derived group R-COO- is an alkyl group having 13 to 23 carbon atoms or an alkenyl group having 13 to 23 carbon atoms; (B) a polyhydric alcohol of trivalent or higher; (C) a polyhydric alcohol of divalent value; (D) an oily component that is liquid at 25°C; (E) a compound represented by formula (I), its salts and mixtures thereof; and (F) a nonionic surfactant other than component (A) and component (E) with an HLB of 4.5 to 12.0, and substantially free of water.

It suppresses the expression of matrix metalloproteinase 1. [Solution] The disclosed matrix metalloproteinase 1 expression inhibitor contains as an active ingredient at least one selected from the group consisting of Saxifraga stolonifera, Saxifraga stolonifera extract, Rosemary, Rosemary extract, Licorice, Licorice extract, Melissa, Melissa extract, Wild thyme, Wild thyme extract, Hops, and Hops extract.

The objective is to provide an active ingredient for topical skin preparations or food and beverages that is derived from natural products, has excellent biocompatibility and stability, and further possesses excellent skin penetration and metabolic properties. [Solution] A topical skin preparation or food / beverage containing a fish scale extract solution or a fermented product of fish scales by microorganisms as an active ingredient, characterized in that the microorganisms have protease activity or aminopeptidase activity.

To provide a skin external preparation containing hydrolyzed gardenia extract that allows suppression of discoloration of the hydrolyzed gardenia extract and enables application to a broad range of formulations.SOLUTION: A skin external preparation contains (A) hydrolyzed gardenia extract and (B) nicotinamide. By containing (A) hydrolyzed gardenia extract and (B) nicotinamide, the skin external preparation prevents discoloration of the hydrolyzed gardenia extract while enabling application to a broad range of formulations.SELECTED DRAWING: None

To provide a skin care preparation effective for improving skin elasticity and / or improving flabby skin.SOLUTION: The heparinoid is used as an active ingredient of a skin care preparation for external use effective for improving skin elasticity and / or improving sagging skin.SELECTED DRAWING: None

To provide a skin care composition containing nicotinic acid amide and suppressing sticky feeling.SOLUTION: The skin care preparation composition comprises (A) nicotinic acid amide, (B) polyvinylpyrrolidone and (C) a granular water-absorbing polymer. Since the skin external preparation composition contains the component (A) to the component (C), it is possible to suppress a sticky feeling while imparting moisture to the skin and improving deep wrinkles, and further, it is possible to sufficiently feel freshness of the preparation, suppress a squeaky feeling, and provide a property of being less likely to drip down.SELECTED DRAWING: None

The present invention relates to [1] an external skin preparation containing a tabular metal oxide (A) having a thickness of 30 to 360 nm and an aspect ratio of 50 to 300, and a UV absorbent (B) in a ratio [(A) / (B)] by mass of 0.1 to 5; [2] an external skin reparation containing the tabular metal oxide (A), a UV scattering agent (C) and a nonvolatile oil (D) in a ratio [(A) / (C)] by mass of 0.1 to 18; and [3] a method for protecting skin from IR rays and UV rays by applying the external skin preparation to skin.

To provide a marker for evaluating the effectiveness of an external preparation for skin, and a method for evaluating the effectiveness of an external preparation for skin using the marker and a method for selecting an effective external preparation for skin using the marker.SOLUTION: A method for evaluating the skin scale ameliorating effect of an external preparation for skin is provided, including the step in which on-skin lipids taken from the skin treated with the external preparation for skin are measured for the expression level of at least one selected from the group consisting of following genes: ARAP2, DENR, SPSB3, TMEM50A, SPNS2, and BICD2, and expression products of these genes.SELECTED DRAWING: None

The present invention addresses the problem of providing a novel topical skin preparation. The present invention provides a topical skin preparation or the like containing glycylglycine and retinol acetate.

This invention provides a composition that can improve skin dullness, enhance transparency, and correct uneven skin tone. [Solution] One or more ingredients selected from the group consisting of scutellaria baicalensis extract and devil's claw extract are used as the active ingredient of the lipofuscin accumulation inhibitor. The lipofuscin accumulation inhibitor can be contained in a composition for improving skin dullness and is suitable as a topical skin preparation or food / beverage.

To provide a skin external preparation which suppresses a sticky sensation during application and a squeaking sensation after application attributable to niacinamide, and which further exhibits excellent stability with time.SOLUTION: A skin external preparation according to the present invention is characterized by containing the following components (A) and (B): (A) niacinamide; and (B) an alkyl glucoside / higher alcohol mixture.SELECTED DRAWING: None

To provide a skin external preparation containing hydrolyzed gardenia extract that allows suppression of discoloration of the hydrolyzed gardenia extract and enables application to a broad range of formulations.SOLUTION: A skin external preparation contains (A) hydrolyzed gardenia extract and (B) bilberry leaf extract and / or rice bran extract. By containing (A) hydrolyzed gardenia extract and (B) bilberry leaf extract and / or rice bran extract, the skin external preparation prevents discoloration of the hydrolyzed gardenia extract while enabling application to a broad range of formulations.SELECTED DRAWING: None

The embodiment of the invention discloses a novel compound. The structure of the compound is shown in a formula (1). The compound shown in the formula (1) has a hyaluronidase inhibition function. Based on the compound shown in the formula (1), the invention further provides a corresponding preparation method and application, and an external skin preparation and an activity inhibitor containing the compound shown in the formula (1).

To provide a skin care preparation which is derived from a natural product, is excellent in biological safety, and exhibits functions of preventing or improving skin roughness, improving the transparency of the skin, and suppressing cell aging by suppressing the secretion of inflammatory substances (cytokine and chemokine) in the skin.SOLUTION: An extract of Gentiana lutea belonging to the genus Gentiana of the family Gentianaceae and an extract of Bletilla striata belonging to the genus Bletilla of the family Orchidaceae are used as active ingredients for suppressing the secretion of inflammatory factor (cytokine and chemokine).SELECTED DRAWING: None

To provide an agent for controlling the formation of a biofilm of Staphylococcus that can suitably control the formation of each biofilm of Staphylococcus epidermidis and Staphylococcus aureus, and an external preparation for skin.SOLUTION: The present invention provides an agent for controlling the formation of a biofilm of Staphylococcus, and an external preparation for skin, each containing at least one of a chitosan derivative chemically modified with an amino group moiety, and β chitin fibers.SELECTED DRAWING: Figure 1

One aspect relates to a method for preparing a low-molecular-weight oat peptide mixture, comprising the steps of: adding an acid to an oat extract so as to obtain an oat protein precipitate; and adding an enzyme complex to the oat protein precipitate so as to obtain a low-molecular-weight oat peptide mixture. It has been identified that the low-molecular-weight oat peptide mixture prepared using the method has excellent effects of strengthening the skin barrier, alleviating skin inflammation, alleviating itchiness, and alleviating skin redness, and has a superior synergistic effect when used in combination with panthenol, and thus can be used as a cosmetic composition, a composition for external application to the skin, a pharmaceutical composition, and the like.

To provide a skin care preparation synergistically improved in moisturizing effect and epidermal barrier function-improving effect by using specific components in combination.SOLUTION: The skin care preparation for external use comprises a citron extract, especially a sphingolipid-containing citron extract, a Rosa rugosa Thunberg flower extract and a fennel extract. The skin care preparation contains one or more kinds of extracts selected from melissa extract, calendula extract, chamomile extract, horsetail extract, horse chestnut extract, hop extract, carrot extract, mistletoe extract, yarrow extract, sage extract, cornflower extract and rosemary extract.SELECTED DRAWING: None

The object of the present invention is to provide a novel kojic acid derivative with excellent solubility in water, and its applications. [Solution] A compound (compound of general formula (1) below) is used in which a phosphocholine group is introduced to the hydroxymethyl group at the 2-position of the γ-pyrone ring of kojic acid via a phosphate ester bond. The kojic acid derivative of the present invention has high solubility in water and can be incorporated into cosmetics and topical skin preparations at high concentrations. Furthermore, the kojic acid derivative of the present invention can be converted to kojic acid in the body, thereby exhibiting the excellent physiological activity of kojic acid, such as melanin production inhibition. TIFF2026055125000008.tif39110

The present invention provides a phospholipid-containing composition containing phospholipids with improved temporal stability compared to conventional compositions, as well as cosmetics and topical skin preparations containing the composition. [Solution] A phospholipid-containing composition with improved long-term stability is provided, characterized by containing (A) a phospholipid with substantially reduced polyvalent cations as an essential component, and further containing one or more of (B) a polyol compound and (C) water. Cosmetics and topical skin preparations are also provided, characterized by being formulated with the phospholipid-containing composition.