70 results about "Topical skin agent" patented technology

To provide a skin treatment composition for wrinkle reduction that is superior in terms of the wrinkle reduction effect, usability, and the sensation during use. A skin treatment composition having a water dispersion of a polymer in which a non-water soluble film-forming polymer is dispersed in water wherein the main ingredients of said film-forming polymer are polyurethane having a film shrinkage rate of 20% or less and an acrylic type polymer having a film shrinkage rate of 20% or less. Also, a skin treatment composition for wrinkle reduction comprising (a) a non-emulsification type cross-linked silicone, (b) a film forming polymer having a film shrinkage rate of 20% or less containing as a main ingredient a polyurethane having a film shrinkage rate of 20%, (c) a liquid oil component, and (d) water.

The present invention provides a substance which promotes the transdermal absorption of a pharmacologically active component while little irritating the skin. The present invention relates to a transdermal absorption promoter which comprises, as the active component, at least one member selected from among isopulegol, 2-(menthoxy)ethanol and 2-methyl-3-(menthoxy)propane-1,2-diol; and an external skin formulation which comprises a pharmacologically active component such as a psychotropic component, an anti-inflammatory component, an analgesic component, an antipyretic component, a whitening component or a hair growth-promoting component, together with the aforesaid transdermal absorption promoter.

The present invention has an object to provide an external dermatological formulation having satisfactory blood flow-promoting effect, antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing effect, hair nourishing effect, emusifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and / or transdermal absorption-promoting effect with a satisfactory safety and skin feeling; The object is solved by providing an external dermatological formulation comprising a saccharide derivative of α,α-trehalose and one or more members selected from substances having any one of blood flow-promoting effect, antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing efect, hair nourishing effect, emulsifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and transdermal absorption-promoting effect.

The present invention provides a foam-type external skin preparation exhibiting an amount of and a retention of carbon dioxide foam appealing to the eye of the user, as well as good usability, such as in preventing the preparation from sagging from the skin, neither of which can be easily obtained with conventional foam-type external skin preparations.The present invention provides a foam-type external skin preparation containing a hydrophobically modified alkyl cellulose as an essential component.

Disclosed is a topical skin formulation and method of using the same to increase the integrity of the dermal-epidermal junction in a person's skin by stimulating the production of proteins and enzymes in dermal and epidermal cells that aid in connecting the dermal layer to the epidermal layer. The composition includes an effective amount of a combination of plant extracts comprising argania spinosa kernel extract and cucurbita pepo seed extract; and an effective amount of a combination of amino acids comprising serine and proline.

An external skin treatment composition containing, based upon the total weight of the composition, 0.001% by mass or more of a diol compound of formula (I), (II), (III), or (IV) or the derivative thereof and a balance of a carrier: wherein R indicates a benzyl group or a phenyl group.

(Problems) To provide a highly safe dietetic composition originating in green coffee beans by which excellent dietetic effects can be obtained and which contributes to the prevention and treatment of life style-related diseases such as diabetes.(Means for Solving Problems) A dietetic composition characterized by comprising, as the active ingredient, a polar solvent extract of defatted green coffee beans. It is preferable that the above-described polar solvent extract is an extract obtained by using water-containing ethanol, still preferably water-containing ethanol having an ethanol concentration of from 40 to 90% (wt / wt). It is preferable that the above-described defatted green coffee beans are those obtained by extracting green coffee beans with N-hexane to thereby separate oily components therefrom. It is recommended to combine the above-described dietetic composition with one or more members selected from among salacia extract, evening primrose extract, sesamine and garcinia. This dietetic composition is usable as a material for foods, drinks, drugs, or skin preparations for external use.

The invention relates to a whitening agent that makes effective use of camu camu seeds, which have conventionally been discarded, and that has high safety and whitening effect useful in cosmetics and the like, as well as skin preparations for external use and cosmetics containing the whitening agent. The whitening agent of the present invention contains camu camu seed extract as an active component, and the skin preparations for external use and cosmetics of the present invention contain the whitening agent.

An dermatological agent for external use is disclosed which contains a chromanol glycoside represented by the following general formula (1) (wherein R1, R2, R3, and R4 which may be the same or different, each represent a hydrogen atom or a lower alkyl group, R5 represents a hydrogen atom, a lower alkyl group, or a lower acyl group, X represents a monosaccharic residue or an oligosaccharic residue optionally having the hydrogen atom of the hydroxyl group in the saccharic residue substituted with a lower alkyl group or a lower acyl group, n represents an integer in the range of 0-6, and m represents an integer in the range of 1-6). This is a novel dermatological agent for external use which excels in stability and percutaneous absorbency, manifests an effective action safely at a small application rate, and effectively prevents and cures the dermopathy. It is very useful as an agent for preventing and curing the disorders caused by the ultraviolet light, an agent for preventing and allaying the sedimentation of pigment in the skin, an agent for beautifying the skin in white, an agent for preventing the senescence of the skin, an agent for activating cells, an agent for preventing and curing the dermopathy, and a cosmetic preparation.

The present invention has an object to provide an external dermatological formulation having satisfactory blood flow-promoting effect, antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing effect, hair nourishing effect, emusifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and / or transdermal absorption-promoting effect with a satisfactory safety and skin feeling; The object is solved by providing an external dermatological formulation comprising a saccharide derivative of α,α-trehalose and one or more members selected from substances having any one of blood flow-promoting effect, antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing efect, hair nourishing effect, emulsifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and transdermal absorption-promoting effect.

A drug for external application to the skin, for inhibiting sebum secretion, comprising a matrix metalloproteinase inhibitor.

(Problems) To provide a highly safe dietetic composition originating in green coffee beans by which excellent dietetic effects can be obtained and which contributes to the prevention and treatment of life style-related diseases such as diabetes.(Means for Solving Problems) A dietetic composition characterized by comprising, as the active ingredient, a polar solvent extract of defatted green coffee beans. It is preferable that the above-described polar solvent extract is an extract obtained by using water-containing ethanol, still preferably water-containing ethanol having an ethanol concentration of from 40 to 90% (wt / wt). It is preferable that the above-described defatted green coffee beans are those obtained by extracting green coffee beans with N-hexane to thereby separate oily components therefrom. It is recommended to combine the above-described dietetic composition with one or more members selected from among salacia extract, evening primrose extract, sesamine and garcinia. This dietetic composition is usable as a material for foods, drinks, drugs, or skin preparations for external use.

Wrinkles are improved by applying an oral preparation, injection preparation or external skin preparation having a substance that controls heparanase as an active ingredient thereof.

Provided are anti-wrinkle agents having a novel scaffold that is suitable as components for external skin preparations such as cosmetics. The anti-wrinkle agents comprise compounds represented by general formula (1), stereoisomers thereof, or pharmacologically acceptable salts thereof. Said anti-wrinkle agents have excellent efficacy in improving wrinkles and sagging that are caused by skin aging with increased age or occur as a result of photoaging due to ultraviolet rays exposure. [In the formula, R1 represents a hydrogen atom or a 1 to 8 carbon straight or branched alkyl group. R2 represents —SH, —SO3H, —S—S—X1, —S—X2, —SO—X3, —SO2—X4, —SO2—NY1—X5 or —SO2—NY2—Y3. X1-X5 independently are hydrogen atoms or 1 to 8 carbon aliphatic hydrocarbon groups or 5 to 12 carbon aromatic moiety wherein carbon atoms may be substituted with heteroatoms. Y1 to Y3 independently represent hydrogen atoms or 1 to 8 carbon linear or branched alkyl groups. R3 represents a hydrogen atom or acyl group having a 1 to 8 carbon straight or branched alkyl chain. R4 represents a 5 to 12 carbon aromatic group or polycyclic condensed aromatic group that may have unsubstituted or substituted groups. m represents an integer 0-3 and n represents an integer 1 or 2.]

The invention relates to a skin preparation for external use, which contains a lamellar structure containing a fatty acid monoglyceride as a main component, and vitamin A or a derivative thereof. The skin preparation for external use has high effects of improving skin roughness and suppressing wrinkling, etc., shows neither any offensive smell nor stickiness, and exhibits controlled foaming upon the production thereof.

The invention provides a plant antibiotic compound spraying agent and a preparation method thereof. The plant antibiotic compound spraying agent is mainly composed of gastrodia tuber, large-flowered skullcap root, Yedo violet, Sophora flavescens, broom cypress fruit, Cotex Dictamni, calyx melo, pomegranate rind, garden burnet, surfactant, cosurfactant and the like. The plant antibiotic compound spraying agent is an external skin preparation with substantial curative effect and capacity of eliminating recurrence, is free of any western medicine and poses no pollution and residual toxicity to human beings and the environment. Clinical test results show that the plant antibiotic compound spraying agent has an action rate of 95% or above and a total effective rate of 99% or above. Through synergism of all the raw materials, the plant antibiotic compound spraying agent has good antibacterial and anti-inflammation effect, is free of irritation to skin and prevents occurrence of allergy. The plant antibiotic compound spraying agent can be used for treating beriberi, burns and scalds, and acne and exerts good curative effect on tinea, scabies and skin diseases of other parts of the body caused by fungi.

This invention relates to compositions and methods for enhancing the penetration of topical skin agents into the skin wherein said compositions contain at least one active ingredient, a skin conditioner and a polymeric emulsifier.

The present invention relates to a skin preparation for external application, comprising a tocopherol aminoalkylcarboxylate ester having no substituent on the N atom and / or a salt thereof. Preferable tocopherol aminoalkylcarboxylate in the present invention is one or more compound selected from α-tocopherol derivatives, β-tocopherol derivatives, γ-tocopherol derivatives and δ-tocopherol derivatives. The present invention also relates to a cosmetic material comprising the skin preparation.

The present invention relates to a skin preparation composition for external use having excellent antiseptic ability without using chemical antiseptics. More particularly, the present invention relates to a skin preparation composition for external use, comprising: glyceryl undecylenate having excellent antiseptic ability; and one or more mixtures of ethylhexylglycerin, glyceryl caprylate, p-anisic acid and a citrus mixed extract, thus improving antiseptic ability through the increased effects of antiseptic abilities of those materials.

It is an object of the present invention to provide anti-allergic agents, skin creams, dermatitis-blocking agents, pollinosis-alleviating agents, and bath agents that serve as antipruritics derived from natural products and that prevent, alleviate and treat various itches felt on the skin. The present invention relates to anti-allergic agents, skin creams, dermatitis-blocking agents, pollinosis-alleviating agents, and bath agents comprising Purpuricenus temminckii frass as an ingredient.

The present invention provides an oil-in-water external skin preparation that has an excellent stability, excellent rough-surface correction effect, and excellent texture. The oil-in-water external skin preparation of the present invention is characterized by comprising (a) an aqueous phase containing resin particles obtained from 100 parts by weight of a vinyl-type monomer and 0.1 to 20 parts by weight of a monomer represented by the below general formula (I),(b) an oil phase, and(c) a surfactant comprising one or more selected from polyoxyethylene hydrogenated castor oil, silicone-type surfactants, and sulfonic acid-type surfactants, in the amount of 0.01 to 5% by mass of the total amount of the external skin preparation and 30% by mass or more of the total amount of surfactants.(In the above formula, R represents a hydrogen atom or a methyl group, 1 represents 1 to 50, and m represents 1 to 50.)

To provide a parakeratosis inhibitor, pore reducing agent and skin roughness preventing / ameliorating agent that exhibit capabilities of parakeratosis inhibition, pore reduction, skin roughness prevention / amelioration, etc., and further provide a skin preparation for external use having these capabilities. There are provide a parakeratosis inhibitor and a pore reducing agent each comprising at least one compound selected from the group consisting of a glycine derivative, an aminodicarboxylic acid derivative, an acylaminodicarboxylic acid derivative, a pyrrolidinecarboxylic acid derivative, a piperidinecarboxylic acid derivative, a hexamethyleneiminecarboxylic acid, a beta-alanine derivative and salts of these derivatives. Further, there are provided a parakeratosis inhibitor, a pore reducing agent and a skin roughness preventing / ameliorating agent each comprising at least one compound selected from the group consisting of specified glycine derivatives and salts thereof and specified aminosulfuric acid derivatives and salts thereof. Still further, there are provided skin preparations for external use comprising these compounds.

The present invention relates to a dendrite elongation inhibitor for melanocytes consisting of a compound represented by the following general formula (1):and / or a salt thereof,wherein R1, R2, and R3 each independently represent a C1-4 alkyl group or hydrogen atom,and a skin preparation for external use comprising the dendrite elongation inhibitor for melanocytes as an active ingredient.

Disclosed are a composition for alleviating ultraviolet irradiation-induced damage, which is stable and safe and can be used on a daily basis, and a pharmaceutical composition, an external skin preparation, a food composition and a medicine for cataract, each comprising aforesaid composition for alleviating ultraviolet irradiation-induced damage. Specifically disclosed is a composition for alleviating ultraviolet irradiation-induced damage which contains one or more kinds of compounds selected from the group consisting of methionine, D-serine and derivatives and / or salts of the same. The aforesaid composition may be an external preparation for the skin, an anti-wrinkle agent, a sunscreen agent, a medicinal composition for treating and / or preventing skin diseases, a food composition or a pharmaceutical product for cataract. In the aforesaid composition for alleviating ultraviolet irradiation-induced damage, the aforesaid methionine may be D-methionine, and the aforesaid D-serine derivative may be D-cycloserine.

The compound of the present invention is a component originated from a natural material, camu camu (Myrciaria dubia), has strong antioxidative activity and stable whitening effect, and is represented by the formula (1). The antioxidant, whitening agent, skin preparation for external use, cosmetics, and food of the present invention are characterized by the inclusion of the compound represented by the formula (1)