Soothing and repairing ancient prescription composition as well as preparation method and application thereof

Abstract

The invention discloses a soothing and repairing ancient prescription composition as well as a preparation method and application thereof. The composition comprises the following components in parts by weight: 10-20 parts of red ginseng, 3-8 parts of red mesona chinensis, 10-15 parts of giant salamander collagen, 0.5-10 parts of a transdermal delivery agent and 20-40 parts of purified water. According to the soothing and repairing ancient prescription composition, the components such as the red ginseng, the red mesona chinensis, the giant salamander collagen and the transdermal delivery agent are compounded, and the transdermal delivery agent has a good transdermal absorption effect, so that transdermal absorption of the effective components such as the red ginseng, the red mesona chinensis and the giant salamander collagen can be promoted, absorption of all the components by the skin is improved, and the soothing and repairing effects are achieved. Therefore, a better allergy-relieving and repairing effect is achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to an ancient soothing and repairing formula composition, a preparation method and application thereof. Background Art

[0002] With the rapid development of diversified cosmetics, consumers are using more and more types of cosmetics and using them more frequently, and the probability of skin contact with irritants is increasing simultaneously. As a result, more and more consumers are experiencing thinning of their stratum corneum and damaged skin barrier, making the number of people with sensitive skin increase day by day. Domestic and foreign markets are also paying more and more attention to products with anti-allergic and repair effects.

[0003] In the prior art, ingredients such as hyaluronic acid and ceramide are often added, such as CN111214386A - A soothing and repairing ancient formula composition containing ectoine and its application. With its small molecule effect, it can quickly penetrate into the skin to achieve its soothing and repairing effect. But in fact, these are only short-term superficial soothing and repairing effects, and some ingredients even accumulate on the surface of the skin. After long-term use, it will cause damage to the skin surface and even cause problems such as skin blockage, which seriously affects the effects of other ingredients. For example, the special viscous texture of hyaluronic acid may make it more difficult to clean than other ingredients, or long-term high-concentration use of certain ceramides may lead to excessive dependence on the skin, because excessive stimulation may destroy the normal skin barrier function, making the skin fragile or overly dry.

[0004] Therefore, developing a novel soothing and repairing product to solve consumers’ main skin problems and increase consumers’ attention to the brand has become a technical issue that needs to be solved urgently. Summary of the invention

[0005] In order to overcome the deficiencies of the prior art, one of the purposes of the present invention is to provide a soothing and repairing ancient formula composition to solve the above-mentioned traditional technical problems.

[0006] The second object of the present invention is to provide a method for preparing the above-mentioned soothing and repairing ancient formula composition.

[0007] The third object of the present invention is to provide an application, wherein the above-mentioned soothing and repairing ancient prescription composition is used in the preparation of cosmetics and / or skin care products. Among them, the skin care products are facial masks, creams, lotions, skin care water, facial cleansers, shampoos, conditioners or shower gels, etc., and are not limited by dosage forms.

[0008] One of the purposes of the present invention is achieved by the following technical solution:

[0009] A soothing and repairing ancient formula composition, comprising the following components in parts by weight:

[0010] 10-20 parts of red ginseng, 3-8 parts of red grass jelly, 10-15 parts of giant salamander collagen, 0.5-10 parts of transdermal delivery agent, and 20-40 parts of purified water.

[0011] Furthermore, red ginseng is an extract of Korean ginseng, which contains active ingredients such as saponins and polyphenolic compounds, has a strong antioxidant effect, can remove free radicals in the body, and delay the aging process.

[0012] Furthermore, the Korean ginseng extract comprises the following preparation steps:

[0013] S1: After sterilizing the Korean ginseng, cut it into slices, place it on a culture medium, and culture it to obtain Korean ginseng stem cells;

[0014] S2: Filter the collected Korean ginseng stem cells through an ultrafiltration membrane, concentrate the filtrate, remove phenol red in the culture medium, and retain the active ingredients;

[0015] S3: placing the active ingredient into a water extraction device for leaching, and repeatedly extracting to obtain a filtrate;

[0016] S4: The filtrate is concentrated and then spray-dried to obtain a Korean ginseng extract.

[0017] Through the above extraction steps, the purity of the extract can be improved and the powder particles can be made smaller, making it easier for it to penetrate into the skin.

[0018] Further, in step S1, the culture medium is WPM culture medium.

[0019] Furthermore, in step S3, hot water is used in the water extraction equipment, and the temperature of the hot water is 40-60°C.

[0020] Furthermore, the Korean ginseng extract contains 85wt%-90wt% of ginsenosides and 10wt%-15wt% of polyphenol compounds.

[0021] Furthermore, the red grass jelly is a red grass jelly extract.

[0022] Furthermore, the red grass jelly extract is one of the five-red grass jelly extract, the six-grass jelly extract, and the nine-grass jelly extract, among which the five-red grass jelly is Smilax china, which is rich in vitamin C and antioxidants, helps to resist the damage of free radicals and promote the regeneration and repair of skin cells; the six-grass jelly is Hexagonal grass jelly, which has multiple functions such as antioxidant, anti-inflammatory, and antibacterial, can effectively protect cells from damage by free radicals, and keep the skin young; the nine-grass jelly, also known as Jiulongcao, Pearl Grass, Wine Grass, Small Star Grass, etc., is rich in flavonoids and antioxidants such as vitamin C, has the characteristics of scavenging free radicals and delaying aging, contains rich volatile oils, and can effectively relieve pain and inflammation.

[0023] The red grass jelly extract is prepared by the steps of water extraction, concentration, spraying and the like.

[0024] Furthermore, the giant salamander collagen is giant salamander hydrolyzed collagen, which uses an enzymatic method to hydrolyze giant salamander skin to obtain collagen peptides with different molecular weights. Giant salamander hydrolyzed collagen has good biocompatibility due to its small molecular weight, can penetrate into the deep layer of the skin, and promote the formation of skin collagen structure.

[0025] The enzymatic hydrolysis method uses pepsin. The molecular weight of giant salamander collagen is 500-800Da.

[0026] Furthermore, the transdermal delivery agent is hydroxyethyl chitosan, which is prepared by a self-assembly method.

[0027] The principle is: the skin has the function of blocking the invasion of harmful substances from the outside world and preventing the loss of nutrients such as water and lipids on the body surface. It is the first physiological barrier of the human body. The similar dissolves theory believes that when the external substance has similar composition, structure and properties as the skin, it is easy to be absorbed through the skin. Similar dissolves, mainly refers to the polar solutes being easily soluble in polar solvents, and non-polar solutes being easily soluble in non-polar solvents. The so-called "similar" mainly refers to the polarity of the molecule. In transdermal absorption, non-polar components can easily penetrate the barrier through the lipid-rich intercellular space (intercellular channels), while polar components rely on cell transport (intracellular channels). Generally speaking, fat-soluble components, that is, components with a large oil / water partition coefficient, are easier to pass through the stratum corneum than water-soluble or hydrophilic components. This is because the lipid bilayer of the intercellular channel has much less resistance than the stratum corneum cells. However, components that are too fat-soluble are also difficult to pass through the hydrophilic area in the lipid bilayer and the hydrophilic active epidermis below the stratum corneum.

[0028] The use of the hydroxyethyl deacetylated chitosan can reduce the skin barrier function by destroying and disrupting the orderly arrangement of lipids between stratum corneum cells or directly extracting lipid components between stratum corneum cells; or by destroying the dense structure of keratin, reducing its barrier resistance and increasing the permeability of chemical substances; or by improving the solubility of the stratum corneum and improving the distribution of chemical substances therein, thereby promoting the absorption of chemical substances in the skin.

[0029] Furthermore, the hydroxyethyl deacetylated chitosan was purchased from Zhongke Houpu (Guangzhou) Technology Development Co., Ltd.

[0030] The second object of the present invention is achieved by adopting the following technical solution:

[0031] A method for preparing a soothing and repairing ancient prescription composition comprises the following steps:

[0032] Add the transdermal delivery agent into the purified water, stir evenly, then add the red ginseng and red grass jelly, mix with ultrasonic for 30-50 minutes, finally add the giant salamander collagen, stir evenly, and the product is obtained.

[0033] In the above steps, the transdermal delivery agent is first ultrasonically mixed with red ginseng, red grass jelly and other ingredients, so that the transdermal delivery agent is loaded on the red ginseng, red grass jelly and other ingredients to facilitate transdermal absorption during use. Giant salamander collagen is subsequently added to enhance the transdermal absorption effect of other ingredients.

[0034] The third object of the present invention is achieved by adopting the following technical solution:

[0035] One application is to use the above-mentioned ancient soothing and repairing formula composition in the preparation of cosmetics and / or skin care products.

[0036] Compared with the prior art, the present invention has the following beneficial effects:

[0037] The soothing and repairing ancient formula composition of the present invention is compounded with ingredients such as red ginseng, red grass jelly, giant salamander collagen and a transdermal delivery agent. Since the transdermal delivery agent has a good transdermal absorption effect, it can promote the transdermal absorption of effective ingredients such as red ginseng, red grass jelly, giant salamander collagen, etc., thereby improving the absorption of each ingredient by the skin, thereby achieving a better soothing and repairing effect. DETAILED DESCRIPTION

[0038] Below, the present invention is further described in conjunction with specific implementation methods. It should be noted that, under the premise of no conflict, the various embodiments or technical features described below can be arbitrarily combined to form new embodiments. In the following embodiments, the Korean ginseng extract contains 85wt% of ginsenosides and 15wt% of polyphenol compounds. The Korean ginseng extract is prepared using the preparation method mentioned in the present invention. The molecular weight of giant salamander collagen is 500-800Da. The hydroxyethyl deacetylated chitosan was purchased from Zhongke Houpu (Guangzhou) Technology Development Co., Ltd.

[0039] Example 1

[0040] A composition comprises the following components in parts by weight:

[0041] 10 parts of Korean ginseng extract, 3 parts of five-red fairy grass extract, 12 parts of giant salamander collagen, 0.5 parts of hydroxyethyl deacetylated chitosan, and 40 parts of purified water.

[0042] The preparation of the above composition is:

[0043] Add hydroxyethyl deacetylated chitosan into purified water, stir evenly, then add Korean ginseng extract and five-red grass jelly extract, mix with ultrasonic for 30-50 minutes, finally add giant salamander collagen, stir evenly, and the product is obtained.

[0044] Example 2

[0045] A composition comprises the following components in parts by weight:

[0046] 10 parts of Korean ginseng extract, 8 parts of five-red fairy grass extract, 12 parts of giant salamander collagen, 0.5 parts of hydroxyethyl deacetylated chitosan, and 40 parts of purified water.

[0047] The preparation of the above composition is:

[0048] Add hydroxyethyl deacetylated chitosan into purified water, stir evenly, then add Korean ginseng extract and five-red grass jelly extract, mix with ultrasonic for 30-50 minutes, finally add giant salamander collagen, stir evenly, and the product is obtained.

[0049] Example 3

[0050] A composition comprises the following components in parts by weight:

[0051] 10 parts of Korean ginseng extract, 15 parts of five-red fairy grass extract, 12 parts of giant salamander collagen, 0.5 parts of hydroxyethyl deacetylated chitosan, and 40 parts of purified water.

[0052] The preparation of the above composition is:

[0053] Add hydroxyethyl deacetylated chitosan into purified water, stir evenly, then add Korean ginseng extract and five-red grass jelly extract, mix with ultrasonic for 30-50 minutes, finally add giant salamander collagen, stir evenly, and the product is obtained.

[0054] Example 4

[0055] A composition comprises the following components in parts by weight:

[0056] 10 parts of Korean ginseng extract, 3 parts of herba schizonepetae extract, 12 parts of giant salamander collagen, 0.5 parts of hydroxyethyl deacetylated chitosan, and 40 parts of purified water.

[0057] The preparation of the above composition is:

[0058] Add hydroxyethyl deacetylated chitosan into purified water, stir evenly, then add Korean ginseng extract and herba seu ...

[0059] Example 5

[0060] A composition comprises the following components in parts by weight:

[0061] 10 parts of Korean ginseng extract, 3 parts of Jiuxiancao extract, 12 parts of giant salamander collagen, 0.5 parts of hydroxyethyl deacetylated chitosan, and 40 parts of purified water.

[0062] The preparation of the above composition is:

[0063] Add hydroxyethyl deacetylated chitosan into purified water, stir evenly, then add Korean ginseng extract and herba serrata extract, mix with ultrasonic for 30-50 minutes, finally add giant salamander collagen, stir evenly, and the product is obtained.

[0064] Comparative Example 1

[0065] The difference from Example 1 is that in Comparative Example 1, an equal amount of water is used to replace the Korean ginseng extract, and the other ingredients and preparation method are the same as those in Example 1.

[0066] That is, the composition comprises the following components in parts by weight:

[0067] 3 parts of five-red fairy grass extract, 12 parts of giant salamander collagen, 0.5 parts of hydroxyethyl deacetylated chitosan, and 50 parts of purified water.

[0068] Comparative Example 2

[0069] The difference from Example 1 is that in Comparative Example 2, an equal amount of water is used to replace the five-red grass jelly grass extract, and other ingredients and preparation methods are the same as those in Example 1.

[0070] That is, the composition comprises the following components in parts by weight:

[0071] 10 parts of Korean ginseng extract, 12 parts of giant salamander collagen, 0.5 parts of hydroxyethyl deacetylated chitosan, and 43 parts of purified water.

[0072] Comparative Example 3

[0073] The difference from Example 1 is that in Comparative Example 3, an equal amount of water is used to replace the giant salamander collagen, and other ingredients and preparation methods are the same as those in Example 1.

[0074] That is, the composition comprises the following components in parts by weight:

[0075] 10 parts of Korean ginseng extract, 3 parts of cyperus rotundus extract, 0.5 parts of hydroxyethyl chitosan, and 52 parts of purified water.

[0076] Comparative Example 4

[0077] Different from Example 1, the Korean ginseng extract in Comparative Example 4 is purchased from outside, and contains 85 wt % of ginsenosides and 15 wt % of polyphenol compounds. Other ingredients and preparation methods are the same as those in Example 1.

[0078] Performance Testing

[0079] 1. Microbiological testing

[0080] The compositions prepared in this example and the comparative example were tested for microbial indicators, and the total number of all colonies was <600 cfu / ml, the total number of molds and yeasts was <80 cfu / ml, and fecal coliform group, Pseudomonas aeruginosa and Staphylococcus aureus were not detected.

[0081] 2. Human efficacy test

[0082] 1. The compositions prepared in this embodiment and the comparative example were subjected to human efficacy tests.

[0083] 2. Prepare soothing repair cream

[0084] The soothing repair cream includes the following components in parts by weight:

[0085] 40 parts of the composition of the comparative example or the embodiment, 5 parts of the acrylate copolymer, 6 parts of ethylene glycol distearate, 4 parts of sodium citrate, 0.2 parts of kason, and 0.1 parts of flavor.

[0086] 3. Effect test

[0087] In order to evaluate the sensory experience of the soothing repair cream, the soothing repair cream was given to 90 volunteers for testing, with 10 people in each test group, aged between 18 and 40 years old. The subjects had dry facial skin, a basic value of stratum corneum moisture content in the facial test area ≤45, poor facial skin barrier function, a basic value of transepidermal water loss ≥15, obvious facial redness and a lactic acid irritation score ≥3. Among them, there were 5 male volunteers and 5 female volunteers, and each test group used one of the test products.

[0088] The volunteers used the soothing repair cream in the same way, applied it on their faces twice a day, used the product for 14 consecutive days, and used the product for 28 consecutive days. They rated the soothing repair cream based on their own experience. The rating was based on a 10-point system, with 0-3 being the worst, 4-6 being moderate, and 7-10 being the best. The higher the score, the better the effect. The irritation was evaluated as mild, general, irritating, etc. The average score of the evaluation of the use effect is listed in Table 1 below.

[0089] Table 1

[0090]

[0091] The above-mentioned embodiments are only preferred embodiments of the present invention and cannot be used to limit the scope of protection of the present invention. Any non-substantial changes and substitutions made by technicians in this field on the basis of the present invention shall fall within the scope of protection required by the present invention.

Claims

1. A soothing and repairing ancient prescription composition, characterized in that: The composition comprises the following components in parts by weight: 10-20 parts of red ginseng, 3-8 parts of red grass jelly, 10-15 parts of giant salamander collagen, 0.5-10 parts of transdermal delivery agent, and 20-40 parts of purified water.

2. The soothing and repairing ancient prescription composition according to claim 1, characterized in that: The red ginseng is a Korean ginseng extract, which contains 85wt%-90wt% of ginsenosides and 10wt%-15wt% of polyphenol compounds.

3. The soothing and repairing ancient prescription composition according to claim 2, characterized in that: The Korean ginseng extract comprises the following preparation steps: S1: After sterilizing the Korean ginseng, cut it into slices, place it on a culture medium, and culture it to obtain Korean ginseng stem cells; S2: Filter the collected Korean ginseng stem cells through an ultrafiltration membrane, concentrate the filtrate, remove phenol red in the culture medium, and retain the active ingredients; S3: placing the active ingredient into a water extraction device for leaching, and repeatedly extracting to obtain a filtrate; S4: The filtrate is concentrated and then spray-dried to obtain a Korean ginseng extract.

4. The soothing and repairing ancient prescription composition according to claim 3, characterized in that: In step S1, the culture medium is WPM medium.

5. The soothing and repairing ancient prescription composition according to claim 3, characterized in that: In step S3, hot water is used in the water extraction equipment, and the temperature of the hot water is 40-60°C.

6. The soothing and repairing ancient prescription composition according to claim 1, characterized in that: The red grass jelly is a red grass jelly extract, and the red grass jelly extract is one of five-red grass jelly extract, six-red grass jelly extract, and nine-red grass jelly extract.

7. The soothing and repairing ancient prescription composition according to claim 1, characterized in that: The molecular weight of the giant salamander collagen is 500-800Da.

8. The soothing and repairing ancient prescription composition according to claim 1, characterized in that: The transdermal delivery agent is hydroxyethyl chitosan, which is prepared by a self-assembly method.

9. A method for preparing the soothing and repairing ancient prescription composition according to any one of claims 1 to 8, characterized in that: The steps include: Add the transdermal delivery agent into the purified water, stir evenly, then add the red ginseng and red grass jelly, mix with ultrasonic for 30-50 minutes, finally add the giant salamander collagen, stir evenly, and the product is obtained.

10. An application, characterized in that: The soothing and repairing ancient formula composition as described in any one of claims 1 to 8 is used in the preparation of cosmetics and / or skin care products.

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