External traditional Chinese medicine composition for alopecia and promoting hair growth and preparation method of external traditional Chinese medicine composition

Abstract

The invention discloses a hair-raising bao series external traditional Chinese medicine composition for alopecia and promoting hair growth and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from a cacumen biotae extract, a prepared polygonum multiflorum extract, an angelica sinensis extract, a mulberry leaf extract, an eclipta prostrata extract, a ginseng extract, a salvia miltiorrhiza extract, an anti-hair loss agent, a hair conditioner, an anti-dandruff agent, a surfactant, a lubricant, a thickener, a preservative, a pH regulator, an emulsifier, a humectant, a suspending agent, a pearling agent and purified water. The anti-hair loss shampoo has good effects of preventing hair loss, growing hair, removing dandruff, relieving itching, controlling oil and the like, and is stable in character and good in anti-hair loss effect. The acceptability of applicable people is high, and the comprehensive effect of the product is better. The method has the advantages of simple process operation, short production period and low cost, improves the paste yield and total solid content of the product, and is suitable for large-scale industrial production.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a Shengfabao series of external Chinese medicine compositions for hair loss and hair growth promotion and a preparation method thereof. Background Art

[0002] Hair loss refers to the phenomenon of hair loss. When the amount of hair loss is roughly the same as the amount of new hair, and the hair density remains basically unchanged, it is normal physiological hair loss; but if the hair growth cycle is unbalanced, the amount of hair loss exceeds the amount of new hair, or the hair growth rate is very slow, resulting in thinning hair, it is pathological hair loss. Pathological hair loss can be divided into alopecia areata, psychogenic hair loss, endocrine disorder hair loss, nutritional hair loss, chemical hair loss, seborrheic alopecia and other types. According to statistics, 95% of hair loss patients suffer from seborrheic alopecia.

[0003] Seborrheic alopecia (AGA) is a hair loss disease determined by genes and affected by androgens, usually accompanied by excessive oil secretion on the scalp. According to the onset time and hair loss pattern, it is divided into male pattern hair loss and female pattern hair loss. Male seborrheic alopecia is mainly manifested by hair loss starting from the two sides of the forehead and gradually extending to the top of the head, or the receding hairline on the forehead with or without progressive hair loss and thinning on the top of the head; the clinical manifestations of women are relatively mild, mainly manifested by diffuse hair loss on the top of the head, which can gradually extend to the temporal and occipital regions. A small number of men may show female pattern baldness, and a small number of women may also show male pattern baldness. The pathogenesis of AGA is still unclear. Some scholars believe that it is related to genetic factors, abnormalities of androgens and androgen receptors, 5α reductase, protease nexin-1, cell growth factors, endocrine factors, local inflammatory stimulation, trace elements, and blood rheology.

[0004] Depending on the degree of hair loss, the corresponding treatment methods are also different. For patients with severe hair loss, clinical treatment needs to be considered, including drug and surgical treatment, but Western medicine treatment has greater side effects on the human body. For example, oral type II 5α-reductase inhibitor finasteride may cause sexual dysfunction; topical growth factor regulator minoxidil may cause hypertrichosis or allergic dermatitis; although hair transplant technology is mature, there are problems such as low survival rate of hair follicles, insufficient donor area, and long operation time. Therefore, it is recommended that patients with mild to moderate hair loss use anti-hair loss and hair growth series care products to protect hair follicles and slow down hair loss. The active ingredients contained in anti-hair loss products mainly include 5α-reductase inhibitors, antibacterial agents, blood circulation improvers around hair follicles, and other types. By stimulating hair roots, regulating biological reactions, improving the growth and development of hair follicles, inhibiting bacteria, and nourishing hair roots, the purpose of strengthening hair roots, firming hair, and promoting hair growth is achieved. As functional shampoo products become more and more popular, raw materials are increasingly inclined to natural raw materials to reduce damage to hair. Under the condition of effective cleaning, more attention is paid to hair care and nourishment, preventing hair loss, nourishing hair roots, and making hair healthy and shiny.

[0005] From the perspective of traditional Chinese medicine, hair loss is related to the liver, kidney, spleen and blood qi of the five internal organs of the human body. Most of them have qi and blood deficiency, enlarged pores, invasion of wind evil, dryness of wind and blood or qi stagnation, blood stasis, and blood cannot rise from the top of the hair, which leads to the emptiness and fall of hair roots. In the external treatment of traditional Chinese medicine, methods such as removing wind and dampness and nourishing hair roots are often used to promote normal hair growth. Wind-removing and moisturizing types include mulberry leaves, aconite, ginger, rattan, cimicifuga, and acacia. Moisturizing ones include Polygonum multiflorum extract, Alternaria japonica juice, and ginseng extract. Blood stasis removers include pine needles, Chuanxiong, Ze Lan, Platycladus orientalis, angelica, and leek root juice. Wind-killing insects include Scutellaria baicalensis, sulfur, and Sophora flavescens. Studies have shown that many Chinese herbal medicines have the effect of preventing hair loss and promoting hair growth.

[0006] Modern studies have shown that ginsenosides in ginseng can promote hair growth through the proliferation of HFDPC (human hair follicle dermal papilla cells), GEF (ginsenoside) stimulates HFDPC proliferation and promotes hair growth in a concentration-dependent manner, and histological analysis shows that the number of hair follicles increased by GEF and minoxidil is similar to the weight of hair. Studies have shown that ginseng extracts have a certain effect on cell proliferation, anti-apoptosis and hair growth. Ecliptae leaves have the activity of promoting hair growth and can enhance the induction of hair growth hormone in the back skin of mice. Ecliptae increases the expression of FGF-7 in C57 / BL6 mice, while reducing the level of FGF-5, activating mTOR (rapamycin target protein) signaling in HDP, and promoting hair growth by regulating the ability of FGF-7 and FGF-5. Platycladus orientalis leaves contain cedarol, which is the main component of Pseudomonas, and it has the potential for hair growth in vivo. The extract of Platycladus orientalis leaves has the effects of promoting hair growth, restoring hair and inhibiting sebum. The extract of Platycladus orientalis leaves has a sebum depleting effect in cultured sebocytes, increases the amount of Wnt10b mRNA in cultured epidermal keratinocytes, and promotes the growth of cultured epidermal keratinocytes in a two-layer culture system of hair papilla cells and epidermal keratinocytes. Therefore, the hair repair agent containing Platycladus orientalis leaves extract helps stimulate hair growth in men and women and inhibits excessive scalp sebum. Therefore, choosing Chinese herbal medicine for anti-hair loss can promote blood circulation in the scalp, improve the growth and development of hair follicles and inhibit bacteria, and has multiple effects such as nourishing hair, nourishing hair roots, and increasing hair gloss.

[0007] Dandruff is a common scalp disease, medically known as "pityriasis capitis". The clinical manifestations are excessive fine gray-white dry or slightly greasy bran-like flakes on the scalp or hair, which may be accompanied by itching, and the incidence rate is high in the population. Dandruff (pityriasis capitis) is generally considered to be a mild non-inflammatory seborrheic dermatitis. Seborrheic dermatitis refers to a chronic inflammatory skin disease in which oily or dry scales with itching appear in areas with abundant sebum secretion, and excludes atopic dermatitis, psoriasis, ichthyosis and other primary diseases. Most studies have shown that the pathogenesis of dandruff is related to microbiological factors and local immune responses. It is generally believed that the colonization of Malassezia yeast, scalp oil secretion and individual susceptibility are the three most important factors. Malassezia, which cannot synthesize fatty acids, tends to inhabit areas of the human body where lipids are secreted, converting lipids secreted by hair follicle glands into free fatty acids and limiting the incomplete β-oxidation pathway for the utilization of unsaturated fatty acids, which may lead to an increase in the proportion of irritating unsaturated fatty acids in human sebum and induce dandruff / seborrheic dermatitis-like dandruff. In addition, studies have found that dandruff is associated with a significant decrease in the levels of free fatty acids, cholesterol, and ceramides in the stratum corneum, which damages the water barrier of the scalp, reduces the hydration of the stratum corneum, and reduces its volume and area, causing it to crack and form scales.

[0008] According to the mechanism of dandruff production, anti-dandruff products currently add various antifungal drugs as the main active ingredients to reduce the growth of scalp microorganisms, inhibit the division of scalp keratinocytes, reduce the rate of epidermal renewal, and prevent the cells that are about to fall off from accumulating into blocky scales visible to the naked eye, thereby achieving the purpose of dandruff removal. Commonly used anti-dandruff agents in the early days include sulfur, salicylic acid, selenium disulfide, etc. Salicylic acid and tar are not designed for antifungal purposes, so they do not have obvious antifungal effects, have poor dandruff removal effects, are highly irritating, and are easy to damage the skin; anti-dandruff products with selenium disulfide as the main active ingredient are also highly irritating, and the hair feels rough after use. If not rinsed thoroughly, the hair may discolor, and a small number of users will accelerate hair loss. Zinc pyrithione, climbazole, and piroctone ethanolamine salt. Due to their good safety and anti-dandruff effects, they are widely used in current anti-dandruff products. The mechanism of piroctone olamine salt in removing dandruff and relieving itching is that it can effectively inhibit bacteria, decompose peroxides, reduce the irritation caused by peroxidation products to the scalp, and has good antioxidant properties. It can fundamentally block the external channels for dandruff production, thereby effectively curing dandruff and itching, rather than temporarily eliminating dandruff from the surface by degreasing. This is one of the reasons why piroctone olamine salt has better anti-dandruff and anti-itching properties than similar products. Soluble piroctone olamine salt can be quickly degraded after being absorbed by the skin, will not accumulate in the skin, and has no adverse effects on the skin. Literature has shown that piroctone olamine salt can increase hair diameter and reduce hair loss compared with ZPT, so piroctone olamine salt can be used to make claims of hair toughness and anti-hair loss. As a new type of anti-dandruff and anti-itching agent, piroctone olamine salt has significant anti-dandruff and anti-itching effects, excellent solubility and compounding properties, and no precipitation and stratification occurs after mixing and compounding with other raw materials. It has a good anti-dandruff effect, low irritation, and good safety performance.

[0009] There are various types of shampoo and cleaning products for dandruff and itching at present, most of which use a single antifungal chemical as an active ingredient, which can cause damage to the scalp if used for a long time. Some shampoo and cleaning products also have a serious irritating effect on the scalp, causing the loss of nutrients in the hair, and the conditioning effect is not ideal, and they do not have the function of conditioning the hair while washing the hair. Existing hair loss prevention and hair growth care products cannot treat both the symptoms and the root causes. Not only are they expensive and have unsatisfactory effects, they even damage the scalp and hair, causing the hair quality to become worse. There are also some shampoo and hair care products for treating hair loss, which contain chemical products that are harmful to the human body, have large side effects, and are not easy to use for a long time. Some people use alkaline shampoo, which has a good degreasing effect, but the human skin is acidic. Using shampoo with too high alkalinity is not conducive to hair growth, and at the same time destroys the physiological environment of the scalp surface. In severe cases, the scalp environment cannot be restored after discontinuation.

[0010] CN 107412709 A, the invention name is "a Chinese herbal medicine composition with the function of stopping hair loss and promoting hair growth", the Chinese herbal medicine composition is prepared from the following raw materials in parts by weight: 15-25 parts of cloves, 9-18 parts of ginger, 16-22 parts of pepper, 4-9 parts of safflower, 18-25 parts of ginseng, 30-38 parts of ganoderma lucidum, 20-40 parts of black sesame, 4-10 parts of mulberry bark, 12-25 parts of ginkgo leaves, 28-40 parts of processed polygonum multiflorum, 8-15 parts of mulberry leaves, 22-33 parts of angelica sinensis, 24-32 parts of arborvitae leaves, 8-12 parts of eclipta prostrata, 6-12 parts of loblolly leaves and 12-18 parts of meadowfoam seed oil, and discloses a preparation method thereof. The invention firstly proportions the composition, filters and extracts it in batches, and then mixes the extracts. The components of the Chinese medicine composition provided by the present invention are reasonably and scientifically formulated, and they work together to prevent hair loss, promote hair growth, and kill bacteria, inhibit bacteria, reduce inflammation, and relieve itching. There are 16 kinds of Chinese herbal medicine raw materials in the invention, and the production cost is relatively high. In addition, some raw materials are prepared by multiple decoctions, extractions, sealed soaking, concentration, etc., and the production process is complicated and the production cycle is relatively long.

[0011] CN105267097A, invention name "A Chinese herbal medicine composition with the function of stopping hair loss and promoting hair growth", the Chinese herbal medicine composition is prepared from the following raw materials in parts by weight: 15-25 parts of cloves, 9-18 parts of ginger, 16-22 parts of pepper, 4-9 parts of safflower, 18-25 parts of ginseng, 30-38 parts of ganoderma lucidum, 20-40 parts of black sesame, 4-10 parts of mulberry bark, 12-25 parts of ginkgo leaves, 28-40 parts of processed Polygonum multiflorum, 8-15 parts of mulberry leaves, 22-33 parts of angelica sinensis, 24-32 parts of Platycladus orientalis leaves, 8-12 parts of Eclipta prostrata, 6-12 parts of loblolly leaves and 12-18 parts of white pondweed seed oil, and discloses a preparation method thereof. The invention firstly proportions the composition, filters and extracts it in batches, and then mixes the extracts. The components of the Chinese medicine composition provided by the present invention are reasonably and scientifically formulated, and they work together to prevent hair loss, promote hair growth, and kill bacteria, inhibit bacteria, reduce inflammation, and relieve itching. The invented product has the effects of removing dandruff and controlling oil, and its effects are relatively single. Summary of the invention

[0012] In order to solve the above technical problems, the present invention provides a Shengfabao series of external Chinese medicine compositions for treating hair loss and promoting hair growth and a preparation method thereof.

[0013] The present invention discloses a Shengfabao series external Chinese medicine composition for hair loss and hair growth promotion, wherein the composition comprises, by weight, 71-710 parts of an anti-hair loss agent, 45-450 parts of a hair conditioner, 3-30 parts of an antidandruff agent, 12-120 parts of a thickener, 10-100 parts of a preservative, 0.5-5 parts of a pH regulator, 280-2800 parts of a detergent, 4.5-45 parts of a moisturizer, 12-120 parts of a suspending agent, 12-120 parts of a pearlescent agent, and 550-5500 parts of purified water;

[0014] Among them, the anti-hair loss agent is composed of 15-150 parts of Platycladus orientalis leaf extract, 3-30 parts of processed Polygonum multiflorum extract, 15-150 parts of Angelica sinensis extract, 10-100 parts of mulberry leaf extract, 8-80 parts of Channa intestine extract, 5-50 parts of ginseng extract, 10-100 parts of Salvia miltiorrhiza extract and 5-50 parts of cedarol by weight.

[0015] Furthermore, the composition is composed of 210-500 parts of anti-hair loss agent, 150-300 parts of hair conditioner, 10-20 parts of anti-dandruff agent, 30-90 parts of thickener, 30-70 parts of preservative, 2-3 parts of pH adjuster, 1000-1800 parts of cleanser, 10-35 parts of moisturizer, 40-80 parts of suspending agent, 40-80 parts of pearlescent agent and 2000-3500 parts of purified water in parts by weight.

[0016] Furthermore, the composition is composed of 300-400 parts of anti-hair loss agent, 200-300 parts of hair conditioner, 15-20 parts of anti-dandruff agent, 50-80 parts of thickener, 40-60 parts of preservative, 2-3 parts of pH adjuster, 1400-1600 parts of cleanser, 20-30 parts of moisturizer, 50-70 parts of suspending agent, 50-60 parts of pearlescent agent and 2500-3500 parts of purified water in parts by weight.

[0017] Furthermore, the anti-hair loss agent is composed of 50-100 parts of Platycladus orientalis leaf extract, 10-20 parts of processed Polygonum multiflorum extract, 50-100 parts of Angelica sinensis extract, 30-70 parts of mulberry leaf extract, 20-60 parts of Channa intestine extract, 10-40 parts of ginseng extract, 30-70 parts of Salvia miltiorrhiza extract and 10-40 parts of cedarol in parts by weight.

[0018] Furthermore, the anti-hair loss agent is composed of 60-80 parts of Platycladus orientalis leaf extract, 15-20 parts of processed Polygonum multiflorum extract, 60-80 parts of Angelica sinensis extract, 40-60 parts of mulberry leaf extract, 30-50 parts of Channa intestine extract, 20-30 parts of ginseng extract, 40-60 parts of Salvia miltiorrhiza extract and 20-30 parts of cedarol in parts by weight.

[0019] Further, the hair conditioning agent is at least one of a polydimethylsiloxane mixture, a polydimethylsiloxane alcohol mixture, a polyquaternium-10 mixture, behenamidopropyl PG-dimethylammonium chloride, and PCA zinc;

[0020] Dimethicone mixture is dimethicone, water, glycerin, trideceth-3, trideceth-10, phenoxyethanol, methylchloroisothiazolinone, methylisothiazolinone, magnesium nitrate or magnesium chloride;

[0021] The dimethicone mixture is dimethicone, water, TEA dodecylbenzene sulfonate, phenoxyethanol, magnesium nitrate, methylchloroisothiazolinone, magnesium chloride or methylisothiazolinone;

[0022] The polyquaternium-10 mixture is polyquaternium-10, water, sodium acetate, sodium chloride or isopropyl alcohol.

[0023] Furthermore, the anti-dandruff agent is piroctone olamine salt.

[0024] Furthermore, the thickener is at least one of cetearyl alcohol and a cocamide MEA mixture; the cocamide MEA mixture is a mixture of cocamide MEA and glycerol.

[0025] Furthermore, the preservative consists of phenoxyethanol and ethylhexylglycerin; and the pH regulator is citric acid.

[0026] Further, the cleaning agent is at least one of ammonium laureth sulfate, ammonium lauryl sulfate, sodium lauroyl sarcosinate, cocamidopropyl betaine mixture, and cocamide MEA; the cocamidopropyl betaine mixture is cocamidopropyl betaine, sodium chloride or water; the moisturizing agent is at least one of hydrogenated lecithin and panthenol; the suspending agent is di(hydrogenated tallow) phthalic acid amide; the pearlescent agent is ethylene glycol distearate

[0027] The preparation method and application of the Shengfabao series of external Chinese medicine compositions for hair loss and hair growth promotion of the present invention are as follows:

[0028] Step 1, weighing and mixing: weighing each Chinese medicine component according to the formula amount of claim 1 and setting aside;

[0029] Step 2, extraction: take the Chinese medicinal components of the above anti-hair loss agent, add purified water respectively, heat to boiling, soak, continue to heat to boiling, decoct 1-2 times, combine the decoctions and filter to obtain an extract;

[0030] Step 3, concentration and sterilization: vacuum concentrate the extract to a relative density of 1.1 to 1.4 at 60°C to obtain a concentrated solution for later use;

[0031] Step 4, preparation: add the concentrated solution into purified water, stir to dissolve, filter, add the anti-hair loss agent and heat to 80-85°C, stir to dissolve, and set aside; add the prepared hair conditioner and cleanser in turn, heat to 80-85°C, stir until all are dissolved, add the prepared hair conditioner, pearlescent agent, thickener, suspending agent, moisturizing agent, stir, cool to 40-50°C, add the prepared cleanser, hair conditioner, moisturizing agent, preservative, anti-dandruff agent, pH adjuster, stir, cool to 25-35°C, filter, and fill.

[0032] Furthermore, the vacuum concentration in step 3 is specifically as follows: the extract is vacuum concentrated to a relative density of 1.0 to 1.1 at 60°C, boiled at normal pressure or kept warm under reduced pressure for 30 minutes, and then continued to concentrate to a relative density of 1.1 to 1.4 at 60°C to obtain a concentrated solution.

[0033] The invention is prepared from Platycladus orientalis leaf extract, prepared Polygonum multiflorum extract, Angelica sinensis extract, mulberry leaf extract, Channa intestine extract, ginseng extract, Salvia miltiorrhiza extract, anti-hair loss agent, hair conditioner, anti-dandruff agent, surfactant, lubricant, thickener, preservative, pH regulator, emulsifier, humectant, suspending agent, pearlescent agent and purified water.

[0034] Platycladus orientalis leaves are the dried branches and leaves of Platycladus orientalis, a plant of the Cupressaceae family. The flavonoids contained in them can activate hair matrix cells and promote blood circulation, revive hair follicles, and achieve the effect of nourishing and growing hair. Modern pharmacological studies have shown that Platycladus orientalis leaf extract can promote local blood circulation, enhance the metabolic function of hair follicles, remove dandruff, promote hair regeneration, and can be used to treat seborrheic alopecia. It can be used alone or boiled with Angelica sinensis, Polygonum multiflorum, Dictamni cortex, and Ligusticum chuanxiong, and the juice can be applied externally to treat premature graying of hair and beard.

[0035] Polygonum multiflorum is a plant of the Polygonaceae family. The lecithin contained in its dried root tubers can promote cell growth and development and is beneficial to hair growth. The diphenylethylene glycosides have the effects of darkening hair, lowering blood lipids, and anti-aging. Processed Polygonum multiflorum can nourish the essence, hair, shins, liver, and kidneys. It is the most commonly used traditional Chinese medicine for gray hair. Studies have shown that Polygonum multiflorum can significantly stimulate the production of melanin in B16 cells in vitro, and its mechanism may be achieved by promoting the gene expression and protein synthesis of tyrosinase and microphthalmia-related transcription factor (MITF) and activating the activity of tyrosinase. Studies have shown that Polygonum multiflorum mainly achieves the purpose of treating hair loss by inducing the proliferation of hair papilla cells.

[0036] Angelica extract has the effect of promoting hair growth in C57BL / 6 mice. The scalp care essence prepared with Angelica extract was tested for efficacy in human trials, and the results showed that Angelica extract can effectively improve the symptoms of hair loss. The results of in vitro experiments and human experiments are consistent.

[0037] Mulberry leaf is the dried leaf of the mulberry plant of the Moraceae family, also known as domestic mulberry, jing mulberry, mulberry tree, yellow mulberry, etc. Mulberry trees are widely planted in all parts of my country, and mulberry leaf production is abundant. Studies have shown that mulberry leaf extract is beneficial to hair growth and has a certain preventive and therapeutic effect on hair loss, premature graying of hair and dry hair.

[0038] Eclipta prostrata, also known as Chanchang, Eclipta prostrata, and Pigtooth Grass, belongs to the plant of the Asteraceae family. It is the whole herb of the plant Chanchang of the Asteraceae family. Li Shizhen of the Ming Dynasty wrote in "Compendium of Materia Medica": "Eclipta prostrata can blacken hair and benefit kidney yin". "Compendium of Materia Medica" believes that Eclipta prostrata "enters the kidney to replenish yin and grow hair." This shows that Eclipta prostrata extract has a certain effect on hair growth.

[0039] Ginseng has significant effects on hair care, hair loss prevention, and dandruff inhibition. Ginseng contains plant hormones related to estrogen, which can improve blood circulation and immunity of the head skin, reduce apoptosis and degeneration of hair follicle keratinocytes in the growth period, prevent and reduce hair loss, promote hair growth and development, promote hair follicle growth, and prolong the hair growth period. Ginseng can expand the capillaries in the head, improve the nutritional status of hair, increase the tensile strength and extensibility of hair, and make hair smoother. Adding ginseng, ginseng extracts, etc. to the formula of hair care products such as shampoo and hair cream can not only make hair smoother and reduce dandruff, but also prevent hair loss and promote the growth of new hair, which can achieve the effect of head beauty.

[0040] Danshen is a traditional precious Chinese medicine in my country, and also has phytoestrogen-like effects. Danshen is one of the most commonly used Chinese medicines for the treatment of hair loss, and is often used in combination with other Chinese medicines. Danshen water extract can effectively promote the regeneration of mouse hair, and its mechanism of action is related to balancing hormone levels and anti-oxidative damage. According to the pharmacological effects of Danshen in the treatment of hair loss, it is expected to have a better therapeutic effect when used in combination with other Chinese medicines.

[0041] Cedarol (CE), also known as cedarwood brain and cedar alcohol, exists in the volatile oils of plants such as Cupressaceae, Taxaceae and Pinaceae. Studies have shown that CE promotes the growth of mouse hair in a dose-dependent manner. CE can prevent cyclophosphamide-induced hair loss in mice and promote hair growth, which shows that cedarol has anti-hair loss effects.

[0042] Compared with the prior art, the beneficial effects of the present invention and the key contents to be protected by the present invention are:

[0043] 1. The preparation method of the present invention: It is prepared by extraction, concentration, preparation and other processes. The process operation is simple, the production cycle is short, the cost is low, and it is suitable for large-scale industrial production.

[0044] 2. The external Chinese medicine composition of the present invention is formulated with Platycladus orientalis leaf extract, Polygonum multiflorum processed extract, Angelica sinensis extract, mulberry leaf extract, Channa intestine extract, ginseng extract, Salvia miltiorrhiza extract anti-hair loss agent, hair conditioner, anti-dandruff agent, surfactant, lubricant, thickener, preservative, pH regulator, emulsifier, humectant, suspending agent, pearlescent agent and purified water.

[0045] The formula uses Chinese herbal extracts as the active ingredients, which work synergistically with the anti-dandruff ingredient of piroctone ethanolamine salt to enhance the metabolic function of hair follicles and remove dandruff.

[0046] 3. The present invention improves the paste yield and total solid content of the product by extracting the Chinese medicinal materials separately.

[0047] 4. The present invention pumps each filtered liquid into a concentrator for segmented vacuum concentration and performs normal pressure / reduced pressure insulation for 30 minutes, thereby eliminating microorganisms in the pipeline and ensuring product quality. The ginseng extract is heat-insulated under reduced pressure to reduce the spraying of ginseng foam, thereby reducing the loss of effective ingredients and energy consumption.

[0048] 5. The present invention uses 3% of cocamidopropyl betaine in combination with ammonium laureth sulfate, sodium lauroyl sarcosinate, etc., which not only improves the foaming property of the product, but also increases the viscosity of the product, achieving a good synergistic effect.

[0049] 6. The present invention obtains a better shampoo product by adjusting the concentration of the Chinese medicine extract concentrate in the formula preparation, and the product properties are stable and the anti-hair loss effect is good.

[0050] 7. In the preparation of phase D, yellow granular block-like insoluble matter is prone to appear. Analysis shows that it may be caused by the insolubility of hydrogenated lecithin or its denaturation by heating. By adjusting the order and method of adding the phase D materials, strictly controlling the dryness and temperature in the tank, and adopting a gradient heating method, the precipitation problem in the phase D solution is solved, and the product stability is improved.

[0051] 8. The results of the human efficacy experiment of the present invention show that compared with before using the product, the hair loss count of the test product did not increase significantly after 4 weeks, 8 weeks, and 12 weeks of use; the difference of hair loss count of the test product after 4 weeks, 8 weeks, and 12 weeks of use was significantly lower than that of the control group (P<0.05). Compared with before using the product, the local hair density of the test product did not decrease significantly after 4 weeks, 8 weeks, and 12 weeks of use. This shows that the product of the present invention has the effect of preventing hair loss.

[0052] 9. The trial evaluation of the product of the present invention shows that the rate of favorable comments on the smoothing effect, oil control effect, anti-itching effect, anti-hair loss effect, hair growth effect, and anti-dandruff effect is over 57%, and the effect is obvious. Through investigation and data analysis of the trial population, the product of the present invention has good effects such as anti-hair loss, hair growth, anti-dandruff and anti-itching, and oil control. The product has high acceptance among the applicable population, and the comprehensive effect of the product is good.

[0053] 10. Through experimental research, the present invention has the effect of promoting hair growth and improving hair quality in androgen-induced alopecia model rats.

[0054] 11. Compared with the patent CN 107412709A, the present invention contains only 6 kinds of Chinese herbal medicine raw materials in the components, the production cost is relatively low, the product is obtained by extraction, concentration and mixing, the method is simple, and it is convenient to carry. It is easy to store and suitable for industrial mass production. Compared with the patent CN105267097A, the present invention can simultaneously have the effects of stopping hair loss and promoting hair growth, removing dandruff and relieving itching. DETAILED DESCRIPTION

[0055] In order to make the objectives, technical solutions and advantages of the embodiments of the present invention more clearly understood, the spirit of the contents disclosed by the present invention will be described in detail below. After understanding the embodiments of the contents of the present invention, any technician in the relevant technical field can change and modify them according to the techniques taught by the contents of the present invention without departing from the spirit and scope of the contents of the present invention.

[0056] The exemplary embodiments of the present invention and the description thereof are used to explain the present invention, but are not intended to limit the present invention. Specific embodiment 1

[0058] 1. Effect of extraction process on product

[0059] Chinese herbal extracts have the effect of preventing hair loss and promoting hair growth. Therefore, the content of its effective ingredients and its physical and chemical properties play an important role in the product. Different extraction methods of medicinal materials have a great influence on the properties and stability of the product. Therefore, the present invention conducts experimental research on the preparation method of Chinese herbal extracts. The experimental method and experimental results are as follows:

[0060] Method 1: Extraction

[0061] (1) Platycladus orientalis leaf extract

[0062] Extraction: put the Platycladus orientalis leaf slices weighed according to the prescription into the extraction tank, add 14 times the amount of water, heat to boiling, soak for 2 hours, continue to heat to boiling, time for 3 hours, filter the decoction, and obtain the extract.

[0063] Concentration and sterilization: The filtered drug solution is pumped into a concentrator for vacuum concentration. When the density is concentrated to 1.01-1.03 (measured at 60°C), it is boiled at normal pressure for 30 minutes and then concentrated to a density of 1.14±0.02 (measured at 60°C) to obtain a concentrated solution (i.e., extract).

[0064] (2) Channa intestine (Eclipta prostrata) extract

[0065] Extraction: put the snakehead intestine slices weighed according to the prescription into the extraction tank, add 14 times the amount of water, heat to boiling, soak for 2 hours, continue to heat to boiling, time for 3 hours, filter the decoction, and obtain the extract.

[0066] Concentration and sterilization: The filtered liquid is pumped into a concentrator for vacuum concentration. When the density is 1.01-1.03 (measured at 60°C), it is boiled at normal pressure for 30 minutes and then concentrated to a density of 1.16±0.02 (measured at 60°C) to obtain a concentrated solution (i.e., extract).

[0067] (3) Angelica Extract

[0068] Extraction: put the slices weighed according to the prescription into the extraction tank, add 12 times the amount of water for the first time, heat to boiling, soak for 2 hours, continue to heat to boiling, time for 2 hours, filter the decoction, add 8 times the amount of water for the second time, decoct for 0.5 hours, filter the decoction to obtain the extract.

[0069] Concentration and sterilization: The filtered drug solution is pumped into a concentrator for vacuum concentration. When the density is concentrated to 1.03-1.07 (measured at 60°C), it is boiled at normal pressure for 30 minutes and then concentrated to a density of 1.33±0.02 (measured at 60°C) to obtain a concentrated solution (i.e., extract).

[0070] (4) Prepared Polygonum multiflorum extract

[0071] Extraction: put the slices weighed according to the prescription into the extraction tank, add 12 times the amount of water for the first time, heat to boiling, soak for 2 hours, continue to heat to boiling, time for 2 hours, filter the decoction, add 8 times the amount of water for the second time, decoct for 0.5 hours, filter the decoction to obtain the extract.

[0072] Concentration and sterilization: The filtered drug solution is pumped into a concentrator for vacuum concentration. When the density is concentrated to 1.03-1.07 (measured at 60°C), it is boiled at normal pressure for 30 minutes and then concentrated to a density of 1.21±0.02 (measured at 60°C) to obtain a concentrated solution (i.e., extract).

[0073] (5) Ginseng Extract

[0074] Extraction: put the slices weighed according to the prescription into the extraction tank, add 12 times the amount of water for the first time, heat to boiling, soak for 2 hours, continue to heat to boiling, time for 2 hours, add 8 times the amount of water for the second time, decoct for 0.5 hours, filter the decoction to obtain the extract.

[0075] Concentration and sterilization: The filtered drug solution is pumped into a concentrator for vacuum concentration. When the density is concentrated to 1.03-1.07 (measured at 60°C), it is maintained at 80-85°C for 30 minutes. Continue to concentrate until the density is 1.21±0.02 (measured at 60°C) to obtain a concentrated solution (i.e., extract).

[0076] (6) Mulberry leaf extract

[0077] Extraction: Put the mulberry leaf slices weighed according to the prescription into the extraction tank, add 14 times the amount of water, heat to boiling, soak for 2 hours, continue to heat to boiling, time for 3 hours, filter the decoction, and obtain the extract.

[0078] Concentration and sterilization: The filtered drug solution is pumped into a concentrator for vacuum concentration. When the density is concentrated to 1.01-1.03 (measured at 60°C), it is boiled at normal pressure for 30 minutes and then concentrated to a density of 1.22±0.02 (measured at 60°C) to obtain a concentrated solution (i.e., extract).

[0079] (7) Salvia miltiorrhiza extract

[0080] Extraction: put the slices weighed according to the prescription into the extraction tank, add 12 times the amount of water for the first time, heat to boiling, soak for 2 hours, continue to heat to boiling, time for 2 hours, filter the decoction, add 8 times the amount of water for the second time, decoct for 0.5 hours, filter the decoction to obtain the extract.

[0081] Concentration and sterilization: The filtered drug solution is pumped into a concentrator for vacuum concentration. When the density is concentrated to 1.03-1.07 (measured at 60°C), it is boiled at normal pressure for 30 minutes and then concentrated to a density of 1.33±0.02 (measured at 60°C) to obtain a concentrated solution (i.e., extract).

[0082] Method 2: Mixed extraction

[0083] Extraction: Weigh 95.7g of Platycladus orientalis leaves, 54.3g of Channa intestines, 75.2g of Angelica sinensis, 95.7g of processed Polygonum multiflorum, 20.9g of ginseng, 75.2g of mulberry leaves, and 83g of Salvia miltiorrhiza, and put them into an extraction tank. Add 12 times the amount of water for the first time, heat to boiling, soak for 2 hours, continue to heat to boiling, time for 2 hours, filter the decoction, add 8 times the amount of water for the second time, decoct for 0.5 hour, filter the decoction, and obtain the extract.

[0084] Concentration and sterilization: The filtered drug solution is pumped into a concentrator for vacuum concentration. When the density is concentrated to 1.03-1.07 (measured at 60°C), it is boiled at normal pressure for 30 minutes and then concentrated to a density of 1.20±0.02 (measured at 60°C) to obtain a concentrated solution (i.e., extract).

[0085] Table 1 Extraction rate and solid content

[0086]

[0087] Table 2 Extraction rate and solid content

[0088]

[0089] Table 3 Comparison of different extraction rates and solid contents

[0090]

[0091] Note: The total solids of mixed medicinal materials g = the amount of each medicinal material in the mixed extraction × dry paste rate

[0092] Converted into mixed medicinal material dry paste rate % = converted into mixed medicinal material total solid / mixed medicinal material total amount

[0093] The experimental results show that when the extract is extracted alone, the dry paste rate and total solid content are greater than those of mixed extraction. The difference in total solid content between single extraction and mixed extraction is about 25.76g / 500g. The difference in paste yield is about 5.15%. From the perspective of extract properties, there is no significant difference between the two. Therefore, after comprehensive consideration, the single extraction method is selected to process the medicinal materials. In this way, more total solid content and paste yield can be obtained.

[0094] 2. Impact of concentration process on products

[0095] The present invention draws each filtered liquid into a concentrator for segmented vacuum concentration, and performs normal pressure / reduced pressure insulation for 30 minutes, thereby eliminating microorganisms in the pipeline and ensuring product quality. Taking ginseng extract as an example, the comparison method and experimental results are as follows:

[0096] Method 1:

[0097] When the ginseng extract is concentrated to a density of 1.03-1.07 (measured at 60°C), it is maintained at 80-85°C for 30 minutes and then further concentrated to 1.21±0.02 (measured at 60°C) to obtain an extract.

[0098] Method 2:

[0099] The ginseng extract was concentrated to a density of 1.21±0.02 (measured at 60° C.) to obtain an extract.

[0100] Table 4 Comparison of different concentration methods of ginseng extract

[0101]

[0102]

[0103] The experimental results show that there is no significant difference in the total saponin content between Method 1 and Method 2. The total colony count in Method 1 is significantly lower than that in Method 2, which shows that reducing pressure and keeping warm for 30 minutes can effectively kill microorganisms in the pipeline and ensure product quality. Ginseng extract uses reduced pressure and keeping warm to reduce the spraying of ginseng foam, which not only reduces the loss of effective ingredients, but also reduces energy loss.

[0104] 3. Effect of concentration of Chinese herbal medicine extract on stability

[0105] Due to its own product characteristics, Chinese herbal extracts will produce some precipitation during the preparation process, affecting the stability and quality of the product. Therefore, the present invention optimizes the performance of the product by adjusting the concentration of the extract and compounding it with other hair conditioners, detergents, thickeners, anti-dandruff agents, etc. The specific experimental results are as follows:

[0106] Table 5 Effect of concentration of Chinese herbal medicine extract on stability

[0107]

[0108] The experimental results show that the density of Chinese medicine extract concentrate is different, which has an important impact on product stability and quality. Under the premise of the same amount of raw medicinal materials, the concentration of Chinese medicine extract concentrate in Scheme 1 is lower than that in Scheme 2. Through stability inspection, Scheme 1 has poor stability and produces dark precipitates, while Scheme 2 has good stability and no precipitation. And the human trial test has the result of preventing hair loss. Therefore, it is determined to choose Scheme 2. Under this test condition, the product properties are stable and the anti-hair loss effect is good.

[0109] 4. Impact of preparation process on products

[0110] Preparation: Add purified water to the concentrated Chinese herbal extract (Platycladus orientalis leaf extract, Angelica sinensis extract, Polygonum multiflorum extract, Channa intestine extract, Panax ginseng extract, Mulberry leaf extract, Salvia miltiorrhiza extract), stir to dissolve, filter, add anti-hair loss agent (cedar alcohol), heat to 80-85°C, stir to dissolve, and set aside. Add the prepared hair conditioner (polyquaternium-10 mixture solution) and cleanser (ammonium laureth sulfate, ammonium lauryl sulfate, sodium lauroyl sarcosinate solution) in sequence, raise the temperature to 80-85°C, stir until all are dissolved, add the prepared hair conditioner (behenamidopropyl PG-dimethylammonium chloride solution), pearlescent agent, thickener, suspending agent, moisturizer (hydrogenated lecithin), stir, cool to 40-50°C, add the prepared cleanser (cocamidopropyl betaine mixture), hair conditioner (polydimethylsiloxane mixture, polydimethylsiloxane alcohol mixture, polyquaternium-10 mixture, PCA zinc), moisturizer (panthenol), preservative, anti-dandruff agent, pH adjuster, stir, cool to 25-35°C and filter.

[0111] Table 6-1 Preparation process scale-up production

[0112]

[0113] Phase D ingredients: hair conditioning agent (behenamidopropyl PG-dimethylammonium chloride solution), pearlescent agent, thickener, suspending agent, moisturizer (hydrogenated lecithin)

[0114] Through observation, the insoluble matter is in the form of yellow granules of varying sizes, with a small weight ratio, but it is visually obvious. Through analysis of the D phase material, hydrogenated lecithin will produce paste-like coagulation and agglomeration in hot water, and the agglomeration is difficult to dissolve. Therefore, it is speculated that this agglomerate is hydrogenated lecithin. Because in the pilot production, the total amount of D phase raw materials is small and easy to disperse, and it is evenly dispersed before reaching high temperature, so there will be no agglomeration phenomenon. After the scale-up production, the total amount of D phase material increases, so during the stirring process, the hydrogenated lecithin cannot be evenly dispersed, and agglomerates are formed when encountering a small amount of water and high temperature, which is difficult to dissolve. Or the temperature is too high, and steam heating can easily lead to local overheating, and hydrogenated lecithin denatures and agglomerates.

[0115] Table 6-2 Comparison of preparation process scale-up production

[0116]

[0117]

[0118] Therefore, when preparing phase D, first weigh the other materials of phase D and put them into the tank, then weigh the hydrogenated lecithin and behenamidopropyl PG-dimethylammonium chloride solution, and stir and mix the two materials evenly before putting them into the tank. Strictly control the amount of water remaining in the tank, release the water in advance after cleaning the tank, place the empty tank, dry the tank or heat it up to dry, and keep the tank free of water before adding phase D. Control the temperature in the tank and review the difference between the actual temperature in the tank and the set temperature. The temperature cannot be higher than 85°C. If it is in the tank (steam heating), it must be heated in a gradient manner, first set to 70°C, then 75°C, then 80°C, and then 85°C. After observing that it is completely dissolved, maintain the current temperature.

[0119] 5. Optimization of product formula

[0120] (1) Effect of detergent on product viscosity

[0121] Sodium lauroyl sarcosinate has excellent cleaning effect, so it is often used as a surfactant. Sodium laureth sulfate has excellent thickening performance and cleaning ability, and is also the most widely used anionic surfactant in the personal care products industry. There are certain performance differences between the two. Different proportions have different effects on the thickening performance of the product. Therefore, the present invention investigates the effects of different ratios and dosages on the viscosity of the product.

[0122] Table 7 Investigation of the dosage of surfactant

[0123]

[0124] The experimental results show that the paste state of Scheme 1 is thinner, Scheme 3 is viscous and has poor fluidity, and Scheme 2 has moderate consistency. This shows that the ratio of ammonium laureth sulfate to sodium lauroyl sarcosinate is 5:1. When the dosage is 20%, the thickening effect is the best, so Scheme 2 is selected.

[0125] (2) Effect of cocamidopropyl betaine on product foaming properties

[0126] Cocamidopropyl betaine (CAPB for short) is a mild, efficient, multifunctional surfactant made from low-cost coconut oil, and is a widely used basic ingredient in shampoo and hair care products. It has significant hard water resistance and can produce abundant foam in both soft and hard water. Therefore, the present invention investigates the effects of different dosages on the foaming performance and viscosity of the product.

[0127] Foam determination method: Determined in accordance with GB / T 29679-2013

[0128] Table 8-1 Investigation on the dosage of cocamidopropyl betaine

[0129]

[0130] The experimental results show that: Scheme 1 has less foam; Scheme 3 has the most foam, but the wet combing effect after washing is poor; Scheme 2 has moderate foam, and the foam volume is significantly improved and rich after trial observation, and the wet combing effect is better. Therefore, Scheme 2 is selected as the formula.

[0131] Table 8-2 Comparative experiment of cocamidopropyl betaine

[0132]

[0133] The experimental results show that: compared with Scheme 1, Scheme 3 has an increase of 231.3% in foam and 81.6% in viscosity; compared with Scheme 2, Scheme 3 has an increase of 55.9% in foam and 128.2% in viscosity, indicating that the use of 3% cocamidopropyl betaine in combination with ammonium laureth sulfate and sodium lauroyl sarcosinate improves the foaming property and viscosity of the product, achieving a good synergistic effect.

[0134] (3) Product stability inspection

[0135] As a raw material for pearlescent agent, ethylene glycol distearate can not only increase the beauty and attractiveness of the product, but also prevent the product from deteriorating due to sunlight. Therefore, the amount of pearlescent agent used affects the pearlescent properties of the product and is also related to the stability of the product.

[0136] Di(hydrogenated tallow)phthalic acid amide is used as a suspending agent to form a gel, which can increase the viscosity and consistency of the product. At the same time, it will also make the cleaning product difficult to rub apart during use, causing a sticky feeling, which in turn affects the product usage experience. Therefore, different amounts of suspending agents have different effects on shampoos.

[0137] Cocamide MEA is often used as a surfactant and thickener in products. It can thicken and opaque the formula and improve the cleaning ability of the main cleaning ingredients in the surfactant. It is often used in hair conditioners, shower gels and other cleaning products.

[0138] The present invention examines different dosages of the above raw materials, and determines the optimal dosage by evaluating the pearlescent properties and stability of the product.

[0139] Table 9 Effects of pearlescent agent, suspending agent and surfactant on product performance

[0140]

[0141] Through the analysis of experimental results, different proportions of pearlescent agent, suspending agent and thickener have a great impact on the product. In Scheme 1, the product has a better pearlescent effect, but the pearlescent agent has precipitation. In Scheme 2, the pearlescent effect is better and there is no precipitation. In Scheme 3, although the pearlescent agent has no precipitation, the pearlescent effect is poor. Therefore, Scheme 2 is selected.

[0142] (4) Impact of anti-dandruff agents on products

[0143] Piroctone olamine salt is one of the most advantageous anti-dandruff agents in terms of anti-dandruff agent poisoning, and can effectively inhibit the growth of Malassezia, thereby effectively removing dandruff. Therefore, the present invention investigates the antibacterial effect of different amounts of piroctone olamine salt on Malassezia, and determines the optimal amount.

[0144] The reference method for antibacterial rate is "Test method for anti-dandruff efficacy of anti-dandruff products".

[0145] Table 10-1 Effect of anti-dandruff agent on anti-dandruff effect of products

[0146]

[0147] Through experimental analysis, with the increase of the dosage of piroctone olamine salt, the antibacterial rate of the product is significantly improved. The antibacterial rates in groups 2, 4, and 6 are respectively increased by 1.1 times, 2.1 times, and 2.7 times compared with the control group, and the antidandruff effect is significantly improved. Compared with the blank group of Chinese medicine extract (group 1, 3, and 5), the antibacterial rates of groups 2, 4, and 6 are respectively increased by 69.0%, 44.4%, and 35.8%, all with significant differences (p < 0.01). This shows that Chinese medicine extract and piroctone olamine salt can work synergistically to improve the antidandruff effect of the product. In the present invention, 0.3% to 0.5% piroctone olamine salt is used as an antidandruff agent, which can effectively inhibit bacteria, remove dandruff for a long time, and has high affinity. Specific embodiment 2

[0149] A Shengfabao series of external Chinese medicine compositions for hair loss and hair growth promotion and preparation method thereof

[0150] This embodiment provides a formula of a Shengfabao series of external Chinese medicine compositions for hair loss and hair growth promotion. The composition is composed of the following components in parts by weight: 349 parts of anti-hair loss agent (72 parts of Platycladus orientalis leaf extract, 16 parts of Polygonum multiflorum extract, 75 parts of Angelica sinensis extract, 46 parts of Morus alba extract, 37 parts of Channa intestine extract, 23 parts of Ginseng extract, 55 parts of Salvia miltiorrhiza extract, 25 parts of cedar alcohol), 225 parts of hair conditioner, 15 parts of antidandruff agent, 60 parts of thickener, 50 parts of preservative, 2.5 parts of pH regulator, 1400 parts of detergent, 22 parts of moisturizer, 60 parts of suspending agent, 60 parts of pearlescent agent, and 2756 parts of purified water.

[0151] The preparation method of the Shengfabao series of external Chinese medicine compositions for hair loss and hair growth promotion of this embodiment comprises the following steps:

[0152] 1. Weighing and mixing ingredients: Weigh each medicinal material according to the recipe and set aside.

[0153] 2. Extraction, concentration and sterilization

[0154] (1) Platycladus orientalis leaf extract

[0155] Extraction: put the Platycladus orientalis leaf slices weighed according to the prescription into the extraction tank, add 14 times the amount of water, heat to boiling, soak for 2 hours, continue to heat to boiling, time for 3 hours, filter the decoction, and obtain the extract.

[0156] Concentration and sterilization: The filtered drug solution is pumped into a concentrator for vacuum concentration. When the density is concentrated to 1.01-1.03 (measured at 60°C), it is boiled at normal pressure for 30 minutes and then concentrated to a density of 1.14±0.02 (measured at 60°C) to obtain a concentrated solution (i.e., extract).

[0157] (2) Channa intestine (Eclipta prostrata) extract

[0158] Extraction: put the snakehead intestine slices weighed according to the prescription into the extraction tank, add 14 times the amount of water, heat to boiling, soak for 2 hours, continue to heat to boiling, time for 3 hours, filter the decoction, and obtain the extract.

[0159] Concentration and sterilization: The filtered liquid is pumped into a concentrator for vacuum concentration. When the density is 1.01-1.03 (measured at 60°C), it is boiled at normal pressure for 30 minutes and then concentrated to a density of 1.16±0.02 (measured at 60°C) to obtain a concentrated solution (i.e., extract).

[0160] (3) Angelica Extract

[0161] Extraction: put the slices weighed according to the prescription into the extraction tank, add 12 times the amount of water for the first time, heat to boiling, soak for 2 hours, continue to heat to boiling, time for 2 hours, filter the decoction, add 8 times the amount of water for the second time, decoct for 0.5 hours, filter the decoction to obtain the extract.

[0162] Concentration and sterilization: The filtered drug solution is pumped into a concentrator for vacuum concentration. When the density is concentrated to 1.03-1.07 (measured at 60°C), it is boiled at normal pressure for 30 minutes and then concentrated to a density of 1.33±0.02 (measured at 60°C) to obtain a concentrated solution (i.e., extract).

[0163] (4) Prepared Polygonum multiflorum extract

[0164] Extraction: put the slices weighed according to the prescription into the extraction tank, add 12 times the amount of water for the first time, heat to boiling, soak for 2 hours, continue to heat to boiling, time for 2 hours, filter the decoction, add 8 times the amount of water for the second time, decoct for 0.5 hours, filter the decoction to obtain the extract.

[0165] Concentration and sterilization: The filtered drug solution is pumped into a concentrator for vacuum concentration. When the density is concentrated to 1.03-1.07 (measured at 60°C), it is boiled at normal pressure for 30 minutes and then concentrated to a density of 1.21±0.02 (measured at 60°C) to obtain a concentrated solution (i.e., extract).

[0166] (5) Ginseng Extract

[0167] Extraction: put the slices weighed according to the prescription into the extraction tank, add 12 times the amount of water for the first time, heat to boiling, soak for 2 hours, continue to heat to boiling, time for 2 hours, add 8 times the amount of water for the second time, decoct for 0.5 hours, filter the decoction to obtain the extract.

[0168] Concentration and sterilization: The filtered drug solution is pumped into a concentrator for vacuum concentration. When the density is concentrated to 1.03-1.07 (measured at 60°C), it is maintained at 80-85°C for 30 minutes. Continue to concentrate until the density is 1.21±0.02 (measured at 60°C) to obtain a concentrated solution (i.e., extract).

[0169] (6) Mulberry leaf extract

[0170] Extraction: Put the mulberry leaf slices weighed according to the prescription into the extraction tank, add 14 times the amount of water, heat to boiling, soak for 2 hours, continue to heat to boiling, time for 3 hours, filter the decoction, and obtain the extract.

[0171] Concentration and sterilization: The filtered drug solution is pumped into a concentrator for vacuum concentration. When the density is concentrated to 1.01-1.03 (measured at 60°C), it is boiled at normal pressure for 30 minutes and then concentrated to a density of 1.22±0.02 (measured at 60°C) to obtain a concentrated solution (i.e., extract).

[0172] (7) Salvia miltiorrhiza extract

[0173] Extraction: put the slices weighed according to the prescription into the extraction tank, add 12 times the amount of water for the first time, heat to boiling, soak for 2 hours, continue to heat to boiling, time for 2 hours, filter the decoction, add 8 times the amount of water for the second time, decoct for 0.5 hours, filter the decoction to obtain the extract.

[0174] Concentration and sterilization: The filtered drug solution is pumped into a concentrator for vacuum concentration. When the density is concentrated to 1.03-1.07 (measured at 60°C), it is boiled at normal pressure for 30 minutes and then concentrated to a density of 1.33±0.02 (measured at 60°C) to obtain a concentrated solution (i.e., extract).

[0175] 4. Weighing: Weigh each material separately according to the batch production volume and keep them for later use.

[0176] 5. Preparation:

[0177] Add purified water to the concentrated Chinese herbal extract (Platararauce leaf extract, Angelica sinensis extract, Polygonum multiflorum extract, Channa intestine extract, Panax ginseng extract, Mulberry leaf extract, Salvia miltiorrhiza extract), stir to dissolve, filter, add anti-hair loss agent (cedar alcohol), heat to 80-85°C, stir to dissolve, and set aside. Add the prepared hair conditioner (polyquaternium-10 mixture solution) and cleanser (ammonium laureth sulfate, ammonium lauryl sulfate, sodium lauroyl sarcosinate solution) in sequence, raise the temperature to 80-85°C, stir until all are dissolved, add the prepared hair conditioner (behenamidopropyl PG-dimethylammonium chloride solution), pearlescent agent, thickener, suspending agent, moisturizer (hydrogenated lecithin), stir, cool to 40-50°C, add the prepared cleanser (cocamidopropyl betaine mixture), hair conditioner (polydimethylsiloxane mixture, polydimethylsiloxane alcohol mixture, polyquaternium-10 mixture, PCA zinc), moisturizer (panthenol), preservative, anti-dandruff agent, pH adjuster, stir, cool to 25-35°C and filter.

[0178] 6. Filling

[0179] Filling is carried out according to product specifications. Specific embodiment 3

[0181] 1. Experiment on the efficacy of the present invention in preventing hair loss.

[0182] 1.1 Subject selection: Eligible subjects were selected according to the inclusion and exclusion criteria, and divided into the experimental group and the control group according to the random table to ensure that the final number of effective cases was no less than 30 people / group.

[0183] Table 1-1 Basic test information

[0184]

[0185] 1.1.1 Selection criteria

[0186] ①18-60 years old, healthy men or women;

[0187] ②Hair length is between 5 and 40 cm;

[0188] ③ Those who are troubled by excessive hair loss and mild hair thinning, and the hair loss count is greater than 10 when combing the hair 60 times, and is still greater than 10 after a 2-week washing period.

[0189] 1.1.2 Exclusion criteria

[0190] ① Pregnant or lactating women;

[0191] ② Patients with severe androgenic alopecia, alopecia areata, inflammatory scar alopecia or other scalp / hair diseases;

[0192] ③ Those who suffer from mental or psychological diseases; or those who have long-term sleep or emotion control disorders;

[0193] ④ Those who have used cosmetics with anti-hair loss effects or other products with such effects or hair growth effects in the past three months;

[0194] ⑤ Those who have taken or topically applied any medication that affects hair growth in the past 6 months;

[0195] 1.2 Test substances

[0196] 1.2.1 Test product: the product obtained in Example 2 above

[0197] 1.2.2 Control product: a product containing the corresponding test matrix formula without anti-hair loss ingredients (Platycladus orientalis leaf extract, Angelica sinensis extract, Polygonum multiflorum extract, Channa intestine extract, Panax ginseng extract, Mulberry leaf extract, Salvia miltiorrhiza extract, cedrol)

[0198] 1.2.3 Usage: Randomly distribute the test product and the control product, and guide the subjects on product use according to the instructions to ensure that the subjects use the test product correctly during the test period. The test product is used for 12 weeks, and the subjects are required to record the use time and any discomfort and adverse reaction symptoms during use.

[0199] 1.3 Test methods

[0200] 1.3.1 The subjects were randomly divided into a test product group and a control product group.

[0201] 1.3.2 Evaluate the basic hair values ​​of the selected subjects before using the product, including hair loss count and hair density assessment, and record them: perform the same assessment and test again 4 weeks, 8 weeks, and 12 weeks after using the product.

[0202] 1.3.3 Hair loss count: Comb the subject's hair 60 times, count the lost hair, and record it.

[0203] 1.3.4 Hair density assessment:

[0204] Local hair density assessment: A 1.5cm*1.5cm haircut area is fixed on the subject's head, positioned properly, and the number and density of local hairs are counted and recorded using image analysis software.

[0205] 1.4 Test results

[0206] 1.4.1 Abnormal test phenomena and skin reaction records

[0207] A total of 70 subjects participated in this trial, 64 of whom were effectively tested. The 64 subjects who completed the trial had no adverse reactions such as erythema, infiltration, papules, and blisters.

[0208] 1.4.2 Test product and control test results

[0209] Table 1-2 Test product and control test results

[0210]

[0211]

[0212] Table 1-3 Comparison results of test products before and after trial

[0213]

[0214] Table 1-4 Comparison of the difference between the test product and the control product before and after trial

[0215]

[0216] 1.5 Test conclusion

[0217] During the test, no subject had local adverse reactions at the site of product use; compared with before use of the product, the hair loss counts of the test product did not increase significantly after 4 weeks, 8 weeks, and 12 weeks of use; the difference in hair loss counts of the test product was significantly lower than that of the control group after 4 weeks, 8 weeks, and 12 weeks of use (P<0.05). Compared with before use of the product, the local hair density of the test product did not decrease significantly after 4 weeks, 8 weeks, and 12 weeks of use. This shows that the product of the present invention has the effect of preventing hair loss.

[0218] 2. Hair growth experimental study

[0219] 2.1 Experimental animals: 60 SPF grade SD male rats

[0220] 2.2 Test substances

[0221] 2.2.1 Experimental product: the product obtained in Example 2 above

[0222] 2.2.2 Positive control: Minoxidil liniment

[0223] 2.2.3 Experimental product matrix: the control product of Example 3 above (the corresponding experimental matrix formula product without Platycladus orientalis leaf extract, Angelica sinensis extract, Polygonum multiflorum extract, Channa intestine extract, Panax ginseng extract, Mulberry leaf extract, Salvia miltiorrhiza extract, and cedrol)

[0224] 2.3 Experimental drug administration

[0225] 2.3.1 Animal model: Preparation of androgenic alopecia rat model. A 4 cm*4 cm area on the back of the rat was taken as the hair loss observation area.

[0226] 2.3.2 Grouping and drug administration: 60 SPF SD male rats were randomly divided into 6 groups, 10 rats in each group, namely blank group, model group, positive control group, and experimental product (low, medium, and high) groups. On the first day of modeling, the drug was applied to the depilated area on the back, left on for 15 minutes, and washed off, once a day. Modeling and drug administration continued for 6 weeks.

[0227] 2.4 Experimental methods

[0228] 2.4.1 Effect of this product on hair growth in rats with androgenic alopecia model

[0229] On the day of hair removal and at the 2nd, 4th, and 6th week of drug administration, the hair length was measured with a vernier caliper, and the hair growth of the rats was scored and evaluated;

[0230] Table 1 Evaluation table of hair growth scores of rats

[0231]

[0232] 2.5 Experimental Results

[0233] 2.5.1 Effect of this product on hair growth in rats with androgenic alopecia model

[0234] Table 1 Hair growth score table of rats with androgenic alopecia model

[0235]

[0236]

[0237] Note: Compared with the blank control group, △P<0.05, △△P<0.01; compared with the model group, *P<0.05, **P<0.01.

[0238] Before the experimental administration, the hair scores of the rats were all 0; during the administration period, the hair growth scores of the model group were significantly reduced compared with the blank group, with significant differences (P<0.05); during the administration period, the hair growth scores of the positive control group, the medium and high dose groups were significantly increased; after 2 weeks of administration, the positive control group, the medium and high dose groups were significantly different from the model group (P<0.05, P<0.01); after 4 weeks of administration, the high dose group was significantly different from the model group (P<0.05); after 6 weeks of administration, the medium and high dose groups were significantly different from the model group (P<0.05). This shows that the product of the present invention has the effect of promoting hair growth in rats with androgenic alopecia model.

[0239] 2.5.1 Effect of the product of the present invention on hair length in rats with androgenic alopecia model

[0240] Table 2 Hair length of rats in androgenic alopecia model

[0241]

[0242] Note: Compared with the blank control group, △P<0.05, △△P<0.01; compared with the model group, *P<0.05, **P<0.01.

[0243] The experimental results show that: during the administration period, the hair length of the model group was significantly reduced compared with the blank group, with significant differences (P<0.05, P<0.01); after 2 weeks of administration, the middle and high dose groups were significantly different from the model group (P<0.05); after 4 weeks of administration, the positive control group, low and high dose groups were significantly different from the model group (P<0.05, P<0.01); after 6 weeks of administration, the positive control group, middle and high dose groups were significantly different from the model group (P<0.05, P<0.01). This shows that the product of the present invention has the effect of promoting hair growth in rats with androgenic alopecia model.

[0244] 3. Questionnaire on the trial effect of the product of the present invention.

[0245] Applicable population: 42 volunteers aged 26-60 years old, including 15 males and 27 females, were selected to try to use the product of the present invention for shampooing.

[0246] Usage: After soaking your hair with warm water, apply an appropriate amount of this product evenly on your hair, massage your hair appropriately, put on a shower cap, leave it on for 10 to 30 minutes, and finally rinse it off with clean water. After one month of trial use, the product's anti-hair loss effect, hair growth effect, anti-dandruff effect, and oil control effect were evaluated, and the product's properties were also evaluated. The specific investigation and analysis results are as follows:

[0247] Table 2-1 Basic information of trial population

[0248]

[0249] Table 2-2 Trial effect survey results

[0250]

[0251]

[0252] The trial data shows that in terms of trial effects, the favorable rates of smoothing effect, oil control effect, anti-itching effect, anti-hair loss effect, hair growth effect, and anti-dandruff effect are all above 57%, and the effects are obvious. In terms of product appearance, the favorable rate of foam is 78.57%.

[0253] Through investigation and data analysis of applicable population, the product of the present invention has good effects of preventing hair loss, promoting hair growth, removing dandruff and relieving itching, controlling oil, etc. The applicable population has high acceptance, and the comprehensive effect of the product is good.

Claims

1. A Shengfabao series of external Chinese medicine compositions for hair loss and hair growth promotion, characterized in that The composition is composed of 71-710 parts of anti-hair loss agent, 45-450 parts of hair conditioner, 3-30 parts of anti-dandruff agent, 12-120 parts of thickener, 10-100 parts of preservative, 0.5-5 parts of pH adjuster, 280-2800 parts of detergent, 4.5-45 parts of moisturizer, 12-120 parts of suspending agent, 12-120 parts of pearlescent agent and 550-5500 parts of purified water in parts by weight; Among them, the anti-hair loss agent is composed of 15-150 parts of Platycladus orientalis leaf extract, 3-30 parts of processed Polygonum multiflorum extract, 15-150 parts of Angelica sinensis extract, 10-100 parts of mulberry leaf extract, 8-80 parts of Channa intestine extract, 5-50 parts of ginseng extract, 10-100 parts of Salvia miltiorrhiza extract and 5-50 parts of cedarol by weight.

2. A Shengfabao series of external Chinese medicine compositions for hair loss and hair growth promotion according to claim 1, characterized in that The composition consists of 210-500 parts of anti-hair loss agent, 150-300 parts of hair conditioner, 10-20 parts of antidandruff agent, 30-90 parts of thickener, 30-70 parts of preservative, 2-3 parts of pH regulator, 1000-1800 parts of detergent, 10-35 parts of moisturizer, 40-80 parts of suspending agent, 40-80 parts of pearlescent agent and 2000-3500 parts of purified water in parts by weight.

3. A Shengfabao series of external Chinese medicine compositions for hair loss and hair growth promotion according to claim 1 or 2, characterized in that The anti-hair loss agent is composed of 50-100 parts of Platycladus orientalis leaf extract, 10-20 parts of processed Polygonum multiflorum extract, 50-100 parts of Angelica sinensis extract, 30-70 parts of mulberry leaf extract, 20-60 parts of Channa intestine extract, 10-40 parts of ginseng extract, 30-70 parts of Salvia miltiorrhiza extract and 10-40 parts of cedarol in parts by weight.

4. A Shengfabao series of external Chinese medicine compositions for hair loss and hair growth promotion according to any one of claims 1 to 3, characterized in that The hair conditioning agent is at least one of a polydimethylsiloxane mixture, a polydimethylsiloxane alcohol mixture, a polyquaternium-10 mixture, behenamidopropyl PG-dimethylammonium chloride, and PCA zinc; Dimethicone mixture is dimethicone, water, glycerin, trideceth-3, trideceth-10, phenoxyethanol, methylchloroisothiazolinone, methylisothiazolinone, magnesium nitrate or magnesium chloride; The dimethicone mixture is dimethicone, water, TEA dodecylbenzene sulfonate, phenoxyethanol, magnesium nitrate, methylchloroisothiazolinone, magnesium chloride or methylisothiazolinone; The polyquaternium-10 mixture is polyquaternium-10, water, sodium acetate, sodium chloride or isopropyl alcohol.

5. A Shengfabao series of external Chinese medicine compositions for hair loss and hair growth promotion according to any one of claims 1 to 3, characterized in that The anti-dandruff agent is piroctone olamine salt.

6. A Shengfabao series of external Chinese medicine compositions for hair loss and hair growth promotion according to any one of claims 1 to 3, characterized in that The thickener is at least one of cetearyl alcohol and a cocamide MEA mixture; the cocamide MEA mixture is a mixture of cocamide MEA and glycerol.

7. A Shengfabao series of external Chinese medicine compositions for hair loss and hair growth promotion according to any one of claims 1 to 3, characterized in that The preservative consists of phenoxyethanol and ethylhexylglycerin; and the pH adjuster is citric acid.

8. A Shengfabao series of external Chinese medicine compositions for hair loss and hair growth promotion according to any one of claims 1 to 3, characterized in that The cleaning agent is at least one of ammonium laureth sulfate, ammonium lauryl sulfate, sodium lauroyl sarcosinate, a cocamidopropyl betaine mixture, and cocamide MEA; the cocamidopropyl betaine mixture is cocamidopropyl betaine, sodium chloride or water; the moisturizing agent is at least one of hydrogenated lecithin and panthenol; the suspending agent is di(hydrogenated tallow) phthalic acid amide; and the pearlescent agent is ethylene glycol distearate.

9. A method for preparing the Shengfabao series of external Chinese medicine compositions for hair loss and hair growth promotion as claimed in claim 1, characterized in that The preparation method is as follows: Step 1, weighing and mixing: weighing each Chinese medicine component according to the formula amount of claim 1 and setting aside; Step 2, extraction: take the Chinese medicinal components of the above anti-hair loss agent, add purified water respectively, heat to boiling, soak, continue to heat to boiling, decoct 1-2 times, combine the decoctions and filter to obtain an extract; Step 3, concentration and sterilization: vacuum concentrate the extract to a relative density of 1.1 to 1.4 at 60°C to obtain a concentrated solution for later use; Step 4, preparation: add the concentrated solution into purified water, stir to dissolve, filter, add the anti-hair loss agent and heat to 80-85°C, stir to dissolve, and set aside; add the prepared hair conditioner and cleanser in turn, heat to 80-85°C, stir until all are dissolved, add the prepared hair conditioner, pearlescent agent, thickener, suspending agent, moisturizing agent, stir, cool to 40-50°C, add the prepared cleanser, hair conditioner, moisturizing agent, preservative, anti-dandruff agent, pH adjuster, stir, cool to 25-35°C, filter, and fill.

10. The method for preparing the Shengfabao series of external Chinese medicine compositions for hair loss and hair growth promotion according to claim 9, characterized in that The vacuum concentration in step 3 is specifically as follows: the extract is vacuum concentrated to a relative density of 1.0 to 1.1 at 60°C, boiled at normal pressure or kept warm under reduced pressure for 30 minutes, and then concentrated to a relative density of 1.1 to 1.4 at 60°C to obtain a concentrated solution.

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