A traditional Chinese medicine for treating rheumatoid arthritis containing paederosida saponins and a preparation method thereof
By preparing pH-responsive and temperature-responsive nanoliposomes, the problems of poor drug targeting and unstable release in the treatment of rheumatoid arthritis were solved, the precise release of drugs in the inflammatory area and sustained therapeutic effects were achieved, and the efficiency and stability of the treatment were improved.
CN119818589BActive Publication Date: 2025-10-21GUANGXI INT ZHUANG MEDICINE HOSPITAL
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Patent Information
- Application Number
- CN202510156472.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-12
- Publication Date
- 2025-10-21
- Estimated Expiration
- 2045-02-12
AI Technical Summary
Technical Problem
Existing drug delivery systems have problems in treating rheumatoid arthritis, such as poor drug targeting, unstable drug release rate, and failure of drugs to accurately reach the site of inflammation, resulting in poor treatment effects.
Method used
pH-responsive and temperature-responsive nanoliposomes are used to prepare nanoliposomes through thin film hydration or layer-by-layer self-assembly methods to ensure precise drug release in the inflammatory area and control the amount and rate of drug release.
Benefits of technology
It achieves precise release of drugs in the inflamed area and sustained therapeutic effects, reduces the impact on healthy areas, and improves the efficiency and stability of treatment.
✦ Generated by Eureka AI based on patent content.
Abstract
The application relates to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine containing Radix Sargentodoxae for treating rheumatic arthritis and a preparation method thereof. The traditional Chinese medicine contains the following components in parts of mass: 30-50 parts of Radix Sargentodoxae, 10-20 parts of Radix Cyathulae, 10-20 parts of Rhizoma Chuanxiong, 10-20 parts of Radix Paeoniae Alba, 5-10 parts of Fructus Lycii, and 5-10 parts of Radix Rehmanniae. The preparation method comprises the following steps: crushing the Radix Sargentodoxae, Radix Cyathulae, Rhizoma Chuanxiong, Radix Paeoniae Alba, Fructus Lycii and Radix Rehmanniae; extracting medicinal components of the above-mentioned medicinal materials; mixing the extract with phospholipids or polymers to form liposomes; the liposomes are pH-responsive nanoliposomes or temperature-responsive nanoliposomes; preparing the nanoliposomes through a film hydration method or a layer-by-layer self-assembly method; and obtaining the traditional Chinese medicine through filtration and drying. The pH-responsive and temperature-responsive nanoliposomes can precisely release the medicine to an inflammation area, ensure that the medicine is released only in a place where treatment is needed, and improve the treatment effect.
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