Leukocyte feedback pipeline system, cartridge and blood cell collection system

Abstract

The invention relates to the technical field of medical instruments, in particular to a leukocyte feedback pipeline system, a cartridge and a blood cell collection system.The pipeline system comprises a change-over valve, a plasma collection pipeline and a backflushing pipeline, and in a circulation path of the backflushing pipeline, a plasma peristaltic pump is arranged between the change-over valve and a centrifugal separation belt; the change-over valve is used for selectively conducting the plasma collection pipeline or the backflushing pipeline, the plasma collection pipeline is used for forward circulation so as to convey separated plasma, and the backflushing pipeline is used for reverse circulation so as to reversely return separated white blood cells. Plasma collection or white blood cell backflushing can be achieved only by switching the connection path of the valve port, and the blood collection valve has the advantages of being simple in structure, easy to operate, wide in application range, low in cost and the like.

Description

Technical Field

[0001] The present application relates to the field of medical device technology, and in particular to a pipeline system, a cassette and a blood cell collection system for white blood cell reinfusion. Background Art

[0002] In the medical field, whole blood component separation pipeline consumables are often used to separate and collect blood components in order to collect certain blood components for clinical infusion or as a treatment method, such as removing excessive red blood cells in the body.

[0003] In the prior art, the blood component separation pipeline is mainly composed of four parts, namely, the connecting pipeline, the cassette, the annular centrifugal separation belt and the blood collection bags of each component. The cassette mainly realizes the whole blood collection and reinfusion process by controlling the peristaltic pumps and control valves, and controls the collection and reinfusion of different components of blood through the different component blood flow channels designed therein; the centrifugal separation belt is mainly used to continuously centrifuge the inflowing anticoagulated whole blood to form component blood in the separation chamber of the separation belt, and it is equipped with a leukocyte separation tower to perform secondary separation and remove leukocytes, so that the leukocytes are retained in the leukocyte separation tower, thereby ensuring the purity of platelets and improving the effectiveness and safety of blood component transfusion; the blood component collection bag is a container for collecting and storing the target component blood that has been separated; the connecting pipeline is used to connect the above three parts in series into an organic whole. The working process is as follows: the pipeline kit is connected to the blood donor through the puncture needle, and the whole human blood is driven by the blood collection peristaltic pump on the cartridge panel to mix with the anticoagulant and enter the cartridge panel pipeline to form anticoagulated whole blood, and enters the centrifugal separation belt through the connecting pipeline for centrifugal separation to form component blood stratification, and the plasma pump, platelet pump, return pump and each component control valve at the cartridge pipeline cooperate with each other to collect the corresponding required component blood, and at the same time, the remaining component blood is returned to the human body. However, due to the retention of white blood cells in the leukocyte separation tower, the white blood cells cannot be returned to the human body. White blood cells are an important component of the body's resistance to pathogen invasion. A reduction in their number may lead to a weakened defense against infection, thereby causing a series of health problems. Once the human body loses too many white blood cells, it will have many adverse effects on health.

[0004] Therefore, there is an urgent need for a pipeline system that can be used to separate blood cells and return the separated white blood cells to the human body, as well as a cassette and a blood cell collection system used in conjunction with the pipeline system. Summary of the invention

[0005] The purpose of the present application is to provide a pipeline system, a cassette and a blood cell collection system for reinfusion of white blood cells, so as to solve the problem that white blood cells cannot be reinfused in the prior art.

[0006] The embodiments of the present application can be implemented through the following technical solutions:

[0007] A pipeline system for reinfusion of leukocytes comprises a conversion valve, a plasma collection pipeline and a backflushing pipeline. In the flow path of the backflushing pipeline, a plasma peristaltic pump is arranged between the conversion valve and the centrifugal separation belt. The conversion valve is used to selectively conduct the plasma collection pipeline or the backflushing pipeline. The plasma collection pipeline is used for forward flow to transport separated plasma, and the backflushing pipeline is used for reverse flow to reversely reinfuse the separated leukocytes.

[0008] Further, the conversion valve comprises a valve body and a valve core, and the three communication ports of the valve body are respectively connected to the first pipeline, the second pipeline, and the third pipeline, which together constitute a two-way return pipeline, and the through connection between the first pipeline and the second pipeline, or the through connection between the third pipeline and the second pipeline is achieved by adjusting the relative position of the valve body and the valve core;

[0009] Wherein, the second pipeline is a common pipeline for the plasma collection pipeline and the backwash pipeline.

[0010] Further, the other end of the first pipeline is connected to a pipeline interface of the centrifugal separation belt, the other end of the second pipeline is connected to the input end of the plasma peristaltic pump, and the other end of the third pipeline serves as a flushing liquid interface of the backwash pipeline;

[0011] The separated plasma passes through the first pipeline via the conversion valve to the second pipeline, and the flushing liquid passes through the third pipeline via the conversion valve to the second pipeline.

[0012] Further, the valve body has a first communication port, a second communication port, and a third communication port that are connected to each other, one end of the valve core is arranged inside the valve body, and correspondingly, two communication holes are arranged in the middle of the valve core, by adjusting the relative positions of the communication holes of the valve core and the communication ports of the valve body;

[0013] The flushing liquid is pressurized to the second pipeline through the third pipeline, the conversion valve and the plasma peristaltic pump, and the liquid flow rate is 16-26 ml / min. At the same time, the rotation speed of the centrifuge rotor is adjusted from the separation speed of 3000 rpm to 200 rpm during blood reinfusion, reducing the centrifugal force of the white blood cells. Under the flushing of the flushing liquid, the white blood cells return to the centrifugal separation belt together with the flushing liquid, return to the reinfusion pool through other loops, and are reinfused into the human body through the reinfusion pump.

[0014] Furthermore, the plasma collection pipeline also includes a first non-controlled pipeline, one end of which is connected to the pipeline output end of the plasma peristaltic pump, and the other end of which serves as a plasma collection interface;

[0015] During the operation of the plasma collection pipeline, whole blood is collected through the blood collection interface, the blood flows through the pipeline to the centrifugal separation belt, and different components of blood are centrifuged out in the centrifugal separation belt, wherein plasma flows in a positive direction through the first pipeline through the conversion valve to the second pipeline, and under the action of the plasma peristaltic pump, through the first non-controlled pipeline to the plasma collection interface.

[0016] Furthermore, the backwash pipeline also includes a second non-control pipeline, one end of which is connected to the pipeline output end of the plasma peristaltic pump, and the other end is connected to another access port of the centrifugal separation belt through a photoelectric sensor pipeline;

[0017] One end of the photoelectric sensor pipeline connected to the second non-control pipeline is also connected to a platelet peristaltic pump. When the backwash pipeline is working, the plasma peristaltic pump remains in an open state and the platelet peristaltic pump remains in a closed state.

[0018] Furthermore, during the operation of the backwash pipeline, flushing liquid is injected from the flushing liquid interface, and the flushing liquid passes through the third pipeline and flows in the reverse direction to the second pipeline via the conversion valve, and under the action of the plasma peristaltic pump, flows through the second non-controlled pipeline to the photoelectric sensor pipeline, and along the photoelectric sensor pipeline to the centrifugal separation belt. Under the action of the plasma peristaltic pump, the flushing liquid impacts the inner wall of the separation tower of the centrifugal separation belt, so that the white blood cells retained on the inner wall of the separation tower are flushed into the flushing liquid, and the flushing liquid carrying the white blood cells is returned to the blood collection interface through the pipeline in the reverse direction.

[0019] The present application also provides a cassette for accommodating part of the pipelines of the pipeline system as described above, the lower part of the conversion valve is limited in the cassette, the cassette includes an upper cover, a box body, and a plurality of prefabricated pipelines, the upper cover and the box body are detachably connected as a whole, a plurality of the prefabricated pipelines are detachably connected in the cassette, and at least one end of each of the prefabricated pipelines is limited in a limiting hole opened in the side wall of the cassette.

[0020] Furthermore, the prefabricated pipeline includes a blood collection blood line, a return blood line, a cavity pressure sensor line, a photoelectric sensor line, a two-way return line and a non-controlled line, wherein the two-way return line includes a conversion valve, and a first pipeline, a second pipeline, and a third pipeline respectively connected to its three connecting ports.

[0021] Furthermore, the box body is a rectangular structure, the top of the box body is empty, and a plurality of external pipe joint mounting grooves and pump pipe joint mounting grooves are provided on the four sides, and a plurality of positioning structures are provided on the bottom surface of the box body, and each pipeline is respectively positioned on the positioning structure on the bottom surface of the box body, and at least one end is limited to the external pipe joint mounting groove or the pump pipe joint mounting groove, and is tightly covered by the upper cover.

[0022] The present application also provides a blood cell collection system, which adopts the pipeline system as described above, including a blood cell collection bag, a connecting pipeline, a cassette, and a centrifugal separation belt. The blood cell collection bag and the connecting pipeline are provided in multiple numbers. The centrifugal separation belt and multiple blood cell collection bags are respectively connected to the respective interfaces of the cassette through the corresponding connecting pipelines, and a peristaltic pump is provided at the matching position of each pipeline of the cassette, and each peristaltic pump and each component control valve cooperate with each other.

[0023] The embodiments of the present application provide a leukocyte transfusion pipeline system, a cassette, and a blood cell collection system that have at least the following beneficial effects:

[0024] The present application integrates the plasma collection pipeline and the leukocyte backflushing pipeline into a set of pipeline system by setting a conversion valve, and the conversion valve is set between the peristaltic pump and the centrifugal separation belt, so that plasma collection or leukocyte backflushing can be achieved by simply switching the connection path of the valve port. Because the conversion valve is set between the peristaltic pump and the centrifugal separation belt, the plasma peristaltic pump can be used as a power source for the flow of liquid in the leukocyte backflushing pipeline, thereby realizing the reverse flow of flushing liquid in the leukocyte separation tower. At the same time, the centrifuge runs at a low speed, the centrifugal force of leukocytes is greatly reduced, the leukocytes are no longer attached to the tower wall, and the pressurized flushing liquid drives the leukocytes retained in the separation tower to be flushed into the separation belt, thereby realizing that the flushing liquid carrying leukocytes is reversely returned to the reinfusion pool through other pipelines, and the leukocytes are reinfused into the human body, effectively reducing damage to the human body. It has the advantages of simple structure, simple operation, wide range of use, low cost, etc.

[0025] The present application sets a cassette that cooperates with the white blood cell reversible transfusion pipeline system, so that each pipeline inside it is designed as an independent structure as an overall structure, and each control unit is formed by separate welding. The material can use materials of corresponding strength and different medical grades according to its function, which greatly reduces the manufacturing cost and difficulty, as well as the difficulty of material selection. It has the advantages of more reasonable structural design, easy processing, low manufacturing cost, and strong practicality. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 This is a schematic diagram of the overall structure of a blood cell collection system for this application;

[0027] Figure 2It is a flow diagram of a plasma collection pipeline in a blood cell collection system;

[0028] Figure 3 It is a flow diagram of the backwash pipeline in the blood cell collection system;

[0029] Figure 4 It is a schematic diagram of part of the pipelines where the conversion valve is connected with the plasma collection pipeline and the backwash pipeline;

[0030] Figure 5 for Figure 4 Schematic diagram of pipeline decomposition in the figure;

[0031] Figure 6 It is a flow diagram of the platelet collection circuit in this application;

[0032] Figure 7 This is the box structure diagram in this application;

[0033] Figure 8 This is the upper cover structure diagram in this application;

[0034] Fig. 9 This is a schematic diagram of the blood collection tube circuit in this application;

[0035] Fig.10 This is a schematic diagram of the blood transfusion circuit in this application;

[0036] Fig.11 This is a schematic diagram of the cavity pressure pipeline in this application;

[0037] Fig.12 This is a schematic diagram of the photoelectric sensor pipeline in this application.

[0038] Numbers in the figure

[0039] 1-blood cell collection bag; 2-connecting pipeline; 21-platelet collection interface; 22-plasma collection interface; 23-rinsing fluid interface; 24-exhaust interface; 25-anticoagulant interface; 26-blood collection interface; 27-return pipeline interface; 28-anticoagulant pipeline interface; 3-cassette; 30-conversion valve; 301-valve body; 302-valve core; 3011-first connecting port, 3012-second connecting port; 3013-third connecting port; 31-upper cover; 32-cassette body; 33-blood collection blood line; 34-return blood line; 35-cavity pressure sensor pipeline; 36 -photoelectric sensor pipeline; 37-plasma collection pipeline; 38-platelet collection pipeline; 318-limiting opening; 319-limiting strip; 321-first boss; 322-buckle; 23-second boss; 324-cavity accommodating port; 325-limiting partition; 326-third boss; 28-external pipe joint installation groove; 29-pump pipe joint installation groove; 371-first pipeline; 372-second pipeline; 373-first non-control pipeline; 381-plasma peristaltic pump; 382-platelet peristaltic pump; 392-second non-control pipeline; 393-third pipeline;

[0040] 4-centrifugal separation belt; 41-separation tower; 8-pipe joint; 9-pump pipe joint; 10-pressure cover; 11-positive and negative pressure sensor pads; 12-bracket; 13-bubble filter; 14-catheter; 15-return tank; 16-return filter; 17-silica gel pad; 20-photoelectric receiving box. DETAILED DESCRIPTION

[0041] Hereinafter, the present application will be further described based on preferred embodiments with reference to the accompanying drawings.

[0042] In addition, various components on the drawings are enlarged (thickened) or reduced (thinned) for ease of understanding, but this practice is not intended to limit the scope of protection of the present application.

[0043] Words importing the singular also include the plural and vice versa.

[0044] In the description of the embodiments of the present application, it should be noted that if the terms "upper", "lower", "inside", "outside", etc. indicate an orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship in which the products of the embodiments of the present application are usually placed when in use, it is only for the convenience of describing the present application and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present application. In addition, in the description of the present application, in order to distinguish different units, the words first, second, etc. are used in this specification, but these are not limited by the order of manufacture, nor can they be understood as indicating or implying relative importance, and their names may be different in the detailed description and claims of the present application.

[0045] The vocabulary in this specification is used to illustrate the embodiments of the present application, but is not intended to limit the present application. It should also be noted that, unless otherwise clearly specified and limited, the terms "disposed", "connected", and "connected" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, a direct connection, an indirect connection through an intermediate medium, or a connection between the two elements. For those skilled in the art, the specific meanings of the above terms in this application can be specifically understood.

[0046] Figure 1 This is a schematic diagram of the overall structure of a blood cell collection system for this application, such as Figure 1 As shown, a blood cell collection system includes a blood cell collection bag 1, a connecting pipe 2, a cassette 3, and a centrifugal separation belt 4. The blood cell collection bag 1 and the connecting pipe 2 are both provided in a plurality of numbers. The centrifugal separation belt 4 and the plurality of blood cell collection bags 1 are respectively connected to the interfaces of the cassette 3 through the corresponding connecting pipes 2, and a peristaltic pump is provided at the fitting position of each pipe of the cassette 3. The peristaltic pumps and the component control valves cooperate with each other to form a whole.

[0047] In some preferred embodiments, the ports of each connecting pipeline 2 are respectively a platelet collection interface 21, a plasma collection interface 22, a flushing liquid interface 23, an exhaust interface 24, an anticoagulant interface 25, a blood collection interface 26, a return pipeline interface 27, and an anticoagulant pipeline interface 28, and each pipeline interface serves as a liquid delivery interface.

[0048] Furthermore, the lower portion of the conversion valve 30 is accommodated in the cartridge 3, and the plasma collection pipeline 37 and the back flushing pipeline 39 are connected in the flow paths of the plasma collection pipeline 37 and the back flushing pipeline 39 through the conversion valve 30. In the flow path of the back flushing pipeline 39, a plasma peristaltic pump 381 is arranged between the conversion valve 30 and the centrifugal separation belt 4. The conversion valve 30 is used to selectively conduct the plasma collection pipeline 37 or the back flushing pipeline 39, so that when the plasma collection pipeline 37 flows in the forward direction, the back flushing pipeline 39 is closed, and the whole blood can be collected at this time. When the back flushing pipeline 39 flows in the reverse direction, the plasma collection pipeline 37 is closed, and the back flushing of white blood cells can be performed at this time.

[0049] In order to clearly show the flow circuits of different pipelines, Figure 2 , Figure 3 The flow paths of the plasma collection pipeline 37 and the backwash pipeline 39 are marked with different colors, wherein the arrows represent the direction of the pipeline flow.

[0050] In some preferred embodiments, the plasma collection pipeline 37, the backflushing pipeline 39, the conversion valve 30, the plasma peristaltic pump 381 and the centrifugal separation belt 4 cooperate to form a pipeline system for the reinfusion of white blood cells, wherein, in the flow path of the backflushing pipeline 39, the plasma peristaltic pump 381 is arranged between the conversion valve 30 and the centrifugal separation belt 4, and the conversion valve 30 is used to selectively conduct the plasma collection pipeline 37 or the backflushing pipeline 39, the plasma collection pipeline 37 is used for forward circulation to transport the separated plasma, and the backflushing pipeline 39 is used for reverse circulation to reversely reinfuse the separated white blood cells.

[0051] Compared with the prior art, the present application creatively sets a conversion valve 30, and sets the plasma peristaltic pump 381 in the backwash pipeline 39 between the conversion valve 30 and the centrifugal separation belt 4. Through the above settings, there is no need to change the collection path of the plasma collection pipeline 39, nor to add an additional power source, so that the plasma peristaltic pump 381 can provide power for the white blood cell transfusion in the backwash pipeline 39. In addition, the plasma peristaltic pump 381 is set at the return output port of the conversion valve 30, and the backwash flow rate of the backwash pipeline 39 can be regulated by the plasma peristaltic pump 381, so that the white blood cell transfusion is more thorough.

[0052] Specifically, Figure 4 They are schematic diagrams of some pipelines in which the conversion valve 30 is connected with the plasma collection pipeline 37 and the backwash pipeline 39. Figure 5 for Figure 4 The pipeline decomposition diagram in Figure 4 , Figure 5 As shown, the conversion valve 30 includes a valve body 301 and a valve core 302, the valve body 301 has a first connecting port 3011, a second connecting port 3012, and a third connecting port 3013 which are interconnected, one end of the valve core 302 is arranged inside the valve body 301, and correspondingly, two connecting holes are arranged at the lower part of the valve core 302, and the relative positions of the connecting holes of the valve core 302 and the connecting ports of the valve body 301 are adjusted to realize the fluid in the conversion valve 30 to flow from the first connecting port 3011 to the second connecting port 3012, or to realize the fluid in the conversion valve 30 to flow from the third connecting port 3013 to the second connecting port 3012, so as to realize the circulation of the plasma collection pipeline 37 and the backwash pipeline 39 respectively.

[0053] Among them, the flushing liquid is pressurized to the second pipeline 372 through the third pipeline 393, the conversion valve 30 and the plasma peristaltic pump 381, and the liquid flow rate is 16-26ml / min. At the same time, the rotation speed of the centrifuge rotor is adjusted from the separation speed of 3000 rpm to 200 rpm during blood reinfusion, thereby reducing the centrifugal force of the white blood cells. Under the flushing of the flushing liquid, the white blood cells can easily return to the centrifugal separation belt 4 together with the flushing liquid, return to the reinfusion pool 15 through other loops, and be reinfused into the human body through the reinfusion pump, thereby achieving full and complete reinfusion of white blood cells.

[0054] In some preferred embodiments, the three connecting ports of the valve body 301 are respectively connected to the first pipeline 371, the second pipeline 372, and the third pipeline 393, which together constitute a two-way return pipeline, wherein one end of the first pipeline 371 is connected to the first connecting port 3011, and the other end is limited to a limiting hole opened on the side wall of the cassette 3 through a pipe joint 9, and is connected to a pipeline of the centrifugal separation belt 4; one end of the second pipeline 372 is connected to the second connecting port 3012, and the other end is limited to another limiting hole opened on the side wall of the cassette 3 through a pump pipe joint 8, and is connected to one of the non-control pipelines in the cassette 3 through the pipeline of the plasma peristaltic pump 381, and the pipe joint 9 and the pump pipe joint 8 are located on the same side of the cassette 3; one end of the third pipeline 393 is connected to the third connecting port 3013, and the other end extends through the side wall of the cassette 3 to the outside of the cassette 3, and is used as a flushing liquid interface.

[0055] In some preferred embodiments, the cartridge 3 is provided with a plurality of non-control pipelines, for example, a first non-control pipeline 373, a second non-control pipeline 392, and the non-control pipelines can also be connected through a three-way valve according to the collection requirements to achieve the collection of other blood components during the plasma collection process, such as establishing a platelet collection pipeline 38, as shown in FIG. Figure 6 shown.

[0056] The plasma collection pipeline 37 and the backwash pipeline 39 are described below in conjunction with the specific working process.

[0057] During the operation of the plasma collection pipeline 37, whole blood is collected through the blood collection interface 26, and the blood flows to the centrifugal separation belt 4 through the pipeline, and different components of blood are centrifuged out in the centrifugal separation belt 4, wherein plasma flows in a positive direction through the first pipeline 371 and the conversion valve 30 to the second pipeline 372, and under the action of the plasma peristaltic pump 381, through the first non-controlled pipeline 373 to the plasma collection interface 22, and is stored in the blood cell collection bag 1 connected to the plasma collection interface 22.

[0058] During the operation of the backwash pipeline 39, flushing liquid is injected from the flushing liquid interface 23, and the flushing liquid passes through the third pipeline 393 and the conversion valve 30 and flows in the reverse direction to the second pipeline 372, and under the action of the plasma peristaltic pump 381, flows through the second non-control pipeline 392 to the photoelectric sensor pipeline 36, and along the photoelectric sensor pipeline 36 to the centrifugal separation belt 4. Under the action of the plasma peristaltic pump 381, the flushing liquid impacts the separation tower 41, and at the same time reduces the centrifugal speed so that the white blood cells no longer adhere to the tower wall, so that the white blood cells retained in the separation tower 41 are flushed by the flushing liquid and mixed with the flushing liquid to flow back to the separation belt 4, and are returned to the return pool 15 through other pipelines in the separation chamber, and then return to the human body through the return pipeline. During this process, the platelet peristaltic pump 382 remains closed.

[0059] In some preferred embodiments, the flushing fluid includes sodium chloride or glucose.

[0060] In some preferred embodiments, in order to achieve the above functions, the applicant creatively designs the cassette 3 as a split structure with upper and lower parts, and improves its structure, changing the integrated structure of the traditional cassette. The traditional cassette needs to be made into two parts, the upper and lower shells, and each pipeline is a half-section structure on the upper and lower shells. After the upper and lower shells are welded together, each pipeline forms a complete closed cavity. Because the pipelines in the shell are complex, each pipeline is relatively independent, each pipeline has a corresponding welding line, the welding area is large, and the welding line is complex. In order to ensure the cleanliness of the inner cavity, the existing technology can only adopt hot plate welding technology. In view of this situation, welding tests on existing domestic medical materials cannot meet the requirements; the processing technology of imported materials is demanding, the raw materials need to be dried before injection molding, the moisture content of the materials does not exceed 3 / 10,000, the injection mold temperature does not exceed 36°C, and special water coolers and dehumidification dryers are required. The parts need to be dried at low temperature before welding, and special low-temperature drying equipment must be configured. The entire production process is complex, difficult to manufacture, and inefficient.

[0061] Specifically, the cassette 3 includes an upper cover 31, a box body 32, and a plurality of prefabricated pipelines. The upper cover 31 and the box body 32 are detachably connected as a whole. The plurality of prefabricated pipelines are detachably connected to the cassette 3, and at least one end of each of the prefabricated pipelines is limited in a limiting hole provided on a side wall of the cassette 3. Each of the prefabricated pipelines forms an independent loop in the cassette that is connected to the outside of the box body, so as to establish a circulation loop and transport blood cells separately.

[0062] In some preferred embodiments, the prefabricated pipeline includes a blood collection blood line 33, a return blood line 34, a cavity pressure sensor line 35, a photoelectric sensor line 36, a two-way return line and a non-controlled line, wherein the two-way return line includes a conversion valve 30, and a first line 371, a second line 372, and a third line 371 respectively connected to its three connecting ports, and each pipeline is respectively limited to a designated position on the inner bottom surface of the box body 32 and is covered by the upper cover 31.

[0063] In some preferred embodiments, the box body 32 is a rectangular parallelepiped structure, the top of the box body 32 is an empty surface, and a plurality of external pipe joint mounting grooves 328 and pump pipe joint mounting grooves 329 are provided on the four sides, and a plurality of positioning structures are provided on the bottom surface of the box body 32, and the plurality of positioning structures are respectively a first boss 321, a cavity accommodating port 324, a second boss 323, a limiting baffle 325, and a third boss 326. Each pipeline is respectively installed at a specified position on the bottom surface of the box body 32, and at least one end is limited in the external pipe joint mounting groove 328 or the pump pipe joint mounting groove 329, and is covered and pressed by the upper cover 31 to fix the connection position of each pipeline to avoid displacement of the end of each pipeline after being connected to the container box.

[0064] In some preferred embodiments, the third boss 326 is an annular structure, and is connected to a plurality of clips 322, and the plurality of clips 322 are arranged along the circumference of the third boss 323. Accordingly, the inner wall of the upper cover 31 is provided with a protruding nail 316 that cooperates with the third boss 326 for positioning the conversion valve 30.

[0065] In some preferred embodiments, a plurality of buckles 322 are connected to the first boss 321 , and the plurality of buckles 322 are arranged along the circumference of the first boss 321 for positioning the positive and negative pressure sensors of the blood collection tube circuit 33 .

[0066] In some preferred embodiments, the blood collection tube circuit 33 includes a positive and negative pressure sensor assembly, a catheter 14, a pipe joint 8 and a pump pipe joint 9. The pipe joint 8 and the pump pipe joint 9 are respectively connected to the two ends of the positive and negative pressure sensor assembly through the catheter 14. During installation, the positive and negative pressure sensor assembly is welded or pressed to the corresponding position of the box body 32, the pump pipe joint 9 is installed in the pump pipe joint installation groove 329, and the pipe joint 8 is installed in the outer pipe joint installation groove 328 to form a loop for later blood transportation.

[0067] In some preferred embodiments, Fig. 9As shown, the positive and negative pressure sensor assembly includes a bracket 12, a bubble filter 13, and positive and negative pressure sensors. The positive and negative pressure sensors and the bubble filter 13 are connected and welded to the bracket 12. The other end of the bubble filter 13 is connected to the pump pipe joint 9 through the conduit 14, and the other end of the positive and negative pressure sensors is connected to the pipe joint 8.

[0068] In some preferred embodiments, the positive and negative pressure sensing pads 11 are made of medical silicone vulcanized with a pre-set stainless steel pad.

[0069] In some preferred embodiments, the positive and negative pressure sensors are welded by the bracket 12 and the pressure cover 10 and press-fitted onto the positive and negative pressure sensing pad 11 to achieve an integrated structure.

[0070] In some preferred embodiments, a plurality of buckles 322 are disposed outside the cavity receiving opening 324 , and the plurality of buckles 322 are disposed along the periphery of the cavity receiving opening 324 for fixing the reinfusion pool 15 of the reinfusion blood line 34 .

[0071] In some preferred embodiments, Fig.10 As shown, the reinfusion blood line 34 includes a reinfusion pool 15, a reinfusion filter 16, a catheter 14, and a pump pipe joint 9 which are connected in sequence. During installation, the reinfusion pool 15 is welded to a specified position on the bottom surface of the box body 32. One port of the reinfusion pool 15 is connected to the reinfusion filter 16, and the other port passes through a side wall of the box body 32. The pump pipe joint 9 is also connected to the same side wall. The pump pipe joint 9 is installed in a pump pipe joint installation groove 329. The reinfusion blood line 34 is used to complete blood reinfusion.

[0072] In some preferred embodiments, a plurality of buckles 322 are connected to the second boss 323 , and the plurality of buckles 322 are arranged along the circumference of the second boss 323 for positioning the cavity pressure sensor of the cavity pressure sensor pipeline 35 .

[0073] In some preferred embodiments, Fig.11 As shown, the cavity pressure sensor pipeline 35 is composed of a cavity pressure sensor assembly, a pump pipe joint 9, a pipe joint 8, and a catheter 14. The pump pipe joint 9 and the pipe joint 8 are respectively connected to the two ends of the cavity pressure sensor assembly through the catheter 14. The cavity pressure sensor assembly is welded by a bracket 12 and a pressure cover 10 and pressed onto a silicone pad 17.

[0074] In some preferred embodiments, the limiting partition 325 is arranged along the length direction of the box body 32, and the limiting partition 325 is provided with a plurality of grooves penetrating along the width direction of the box body 32 for locating ports of some pipelines.

[0075] In some preferred embodiments, Fig.12 As shown, the photoelectric sensor pipeline 36 consists of a photoelectric receiving box 20, a tee 7, a catheter connector 8, a pump pipe connector 9 and a plurality of catheters 14. The photoelectric receiving box 20 contains a receiving device for transmitting signals. One end of the photoelectric receiving box 20 is connected to the catheter connector 8 through the catheter 14, and the other end is connected to the tee 7 through the catheter 14. The other two ends of the tee 7 are respectively connected to the catheter connector 8 and the pump pipe connector 9 through the catheter 14, wherein the pipe connector 8 connected to the tee 7 is located in a groove of the limiting partition 325.

[0076] In some preferred embodiments, the non-control pipeline is composed of a catheter 14, a pump pipe joint 9 or a pipe joint 8, and each non-control pipeline is installed at a designated position according to its functional requirements.

[0077] In some preferred embodiments, a limit strip 319 is further provided on the bottom surface of the box body 32. The limit strip 319 is connected to the inner wall of the bottom surface of the box body 32 to serve as a reinforcing rib and to assist in limiting the conduit 14 in the container box.

[0078] In some preferred embodiments, the first boss 321 and the second boss 323 are annular structures, and the center of the annular structure is a through-hole structure, so that the sensor can be exposed outside the box body 32 for easy operation.

[0079] In some preferred embodiments, the positive and negative pressure sensor components, the reinfusion tank 15, the cavity pressure sensor component, and the photoelectric sensor are all independent welded structures.

[0080] In some preferred embodiments, the consumables are connected to the container box via a pump pipe joint 9 or a pipe joint 8 to achieve blood circulation control.

[0081] In some preferred embodiments, the side wall of the upper cover 31 is also provided with an external pipe joint mounting groove 328 and a pump pipe joint mounting groove 329. When the upper cover 31 and the box body 32 are connected to form a container box, the two split external pipe joint mounting grooves 328 are matched and connected to form a first limiting hole that runs through the inside and outside of the container box. Correspondingly, the two split pump pipe joint mounting grooves 329 are also matched and connected to form a second limiting hole that runs through the inside and outside of the container box, wherein the structure of the first limiting hole is adapted to the structure of the pipe joint 8, and is used to limit the connection position of the pipe joint 8 with the side wall of the container box without positional displacement, and the structure of the second limiting hole is adapted to the structure of the pump pipe joint 9, and is used to limit the connection position of the pump pipe joint 9 with the side wall of the container box without positional displacement.

[0082] In some preferred embodiments, a limiting opening 318 is further provided on the top surface of the upper cover 31, and the limiting opening 318 is adapted to the cavity of the outer wall of the reinfusion pool 15, and the limiting opening 318 and the cavity accommodating opening 324 cooperate with each other to reserve installation space for the reinfusion pool 15 and to limit the reinfusion pool 15.

[0083] In some preferred embodiments, the top inner wall of the upper cover 31 is further provided with a plurality of limit strips 319 , which are connected to the top inner wall of the upper cover 31 and are used as reinforcing ribs and can assist in limiting the conduit 14 in the container box.

[0084] In some preferred embodiments, the upper cover 31 and the bottom and side walls of the box body 32 are 2 mm to 6 mm thick, so as to ensure structural strength without taking up too much space.

[0085] The above is a detailed introduction to the specific implementation methods of the present application. For those skilled in the art, several improvements and modifications may be made to the present application without departing from the principles of the present application. These improvements and modifications also fall within the scope of protection of the claims of the present application.

Claims

1. A leukocyte transfusion pipeline system, characterized in that: The invention comprises a conversion valve (30), a plasma collection pipeline (37), and a back-flushing pipeline (39). In the flow path of the back-flushing pipeline (39), a plasma peristaltic pump (381) is arranged between the conversion valve (30) and the centrifugal separation belt (4). The conversion valve (30) is used to selectively conduct the plasma collection pipeline (37) or the back-flushing pipeline (39). The plasma collection pipeline (37) is used for forward flow to transport separated plasma, and the back-flushing pipeline (39) is used for reverse flow to reversely return separated white blood cells.

2. The leukocyte transfusion pipeline system according to claim 1, characterized in that: The conversion valve (30) comprises a valve body (301) and a valve core (302); the three communication ports of the valve body (301) are respectively connected to a first pipeline (371), a second pipeline (372), and a third pipeline (393), which together constitute a two-way return pipeline; by adjusting the relative position of the valve body (301) and the valve core (302), a through connection between the first pipeline (371) and the second pipeline (372) or a through connection between the third pipeline (393) and the second pipeline (372) is achieved; Wherein, the second pipeline (372) is a common pipeline for the plasma collection pipeline (37) and the backwash pipeline (39).

3. The leukocyte transfusion pipeline system according to claim 2, characterized in that: The other end of the first pipeline (371) is connected to a pipeline interface of the centrifugal separation belt (4), the other end of the second pipeline (372) is connected to the input end of the plasma peristaltic pump (381), and the other end of the third pipeline (393) serves as a flushing liquid interface (23) of the backwash pipeline (39); The separated plasma passes through the first pipeline (371) through the conversion valve (30) to the second pipeline (372), and the flushing liquid passes through the third pipeline (393) through the conversion valve (30) to the second pipeline (372).

4. The leukocyte transfusion pipeline system according to claim 3, characterized in that: The valve body (301) has a first communication port (3011), a second communication port (3012), and a third communication port (3013) which are connected to each other. One end of the valve core (302) is arranged inside the valve body (301). Correspondingly, two communication holes are arranged in the middle of the valve core (302). By adjusting the relative positions of the communication holes of the valve core (302) and the communication ports of the valve body (301); The flushing liquid is pressurized to the second pipeline (372) through the third pipeline (393) through the conversion valve (30) and the plasma peristaltic pump (381), and the liquid flow rate is 16-26 ml / min. At the same time, the rotation speed of the centrifuge rotor is adjusted from the separation speed of 3000 rpm to 200 rpm during blood reinfusion.

5. The leukocyte transfusion pipeline system according to claim 3, characterized in that: The plasma collection pipeline (37) further comprises a first non-control pipeline (373), one end of which is connected to the pipeline output end of the plasma peristaltic pump (381), and the other end of which serves as a plasma collection interface (22); During the operation of the plasma collection pipeline (37), whole blood is collected through the blood collection interface (26), the blood flows through the pipeline to the centrifugal separation belt (4), and different components of blood are centrifuged out in the centrifugal separation belt (4), wherein plasma flows in a positive direction through the first pipeline (371) through the conversion valve (30) to the second pipeline (372), and under the action of the plasma peristaltic pump (381), through the first non-controlled pipeline (373) to the plasma collection interface (22).

6. The leukocyte transfusion pipeline system according to claim 3, characterized in that: The backwash pipeline (39) further comprises a second non-control pipeline (392), one end of which is connected to the pipeline output end of the plasma peristaltic pump (381), and the other end of which is connected to another access port of the centrifugal separation belt (4) via a photoelectric sensor pipeline (36); The photoelectric sensor pipeline (36) is connected to one end of the second non-control pipeline (392) and is also connected to a platelet peristaltic pump (382). When the backwash pipeline (39) is working, the plasma peristaltic pump (381) remains in an open state and the platelet peristaltic pump (382) remains in a closed state.

7. The leukocyte transfusion pipeline system according to claim 6, characterized in that: During the operation of the backwash pipeline (39), flushing liquid is injected from the flushing liquid interface (23), and the flushing liquid passes through the third pipeline (393) and flows in the reverse direction to the second pipeline (372) through the conversion valve (30), and under the action of the plasma peristaltic pump (381), flows through the second non-control pipeline (392) to the photoelectric sensor pipeline (36), and along the photoelectric sensor pipeline (36) to the centrifugal separation belt (4). Under the action of the plasma peristaltic pump (381), the flushing liquid impacts the inner wall of the separation tower (41) of the centrifugal separation belt (4), so that the white blood cells retained on the inner wall of the separation tower (41) are flushed into the flushing liquid, so that the flushing liquid carrying the white blood cells returns to the blood collection interface (26) through the pipeline in the reverse direction.

8. A cassette for accommodating a portion of a pipeline of a pipeline system as claimed in claim 1, characterized in that: The lower part of the conversion valve (30) is limited to be located in the cartridge (3), and the cartridge (3) comprises an upper cover (31), a box body (32), and a plurality of prefabricated pipelines. The upper cover (31) and the box body (32) are detachably connected to form a whole, and the plurality of prefabricated pipelines are detachably connected to the cartridge (3), and at least one end of each of the prefabricated pipelines is limited to be located in a limiting hole provided in a side wall of the cartridge (3).

9. The cassette according to claim 8, characterized in that: The prefabricated pipeline includes a blood collection blood line (33), a blood return blood line (34), a cavity pressure sensor line (35), a photoelectric sensor line (36), a two-way return line and a non-controlled line, wherein the two-way return line includes a conversion valve (30), and a first line (371), a second line (372), and a third line (393) respectively connected to its three connecting ports.

10. The cassette according to claim 9, characterized in that: The box body (32) is a rectangular parallelepiped structure. The top of the box body (32) is a hollow surface, and a plurality of external pipe joint installation grooves (328) and pump pipe joint installation grooves (329) are provided on four sides. The bottom surface of the box body (32) is provided with a plurality of positioning structures. Each pipeline is positioned on the positioning structure on the bottom surface of the box body (32), and at least one end is limited to be located in the external pipe joint installation groove (328) or the pump pipe joint installation groove (329), and is covered and pressed by the upper cover (31).

11. A blood cell collection system, using the pipeline system as claimed in claim 1, characterized in that: The invention comprises a blood cell collection bag (1), a connecting pipe (2), a cartridge (3), and a centrifugal separation belt (4). The blood cell collection bag (1) and the connecting pipe (2) are both provided in a plurality. The centrifugal separation belt (4) and the plurality of blood cell collection bags (1) are respectively connected to the interfaces of the cartridge (3) through the corresponding connecting pipes (2). A peristaltic pump is provided at the joint of each pipe of the cartridge (3), and each peristaltic pump and each component control valve cooperate with each other.

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