2-sulfonylamino pyrrole derivative and preparation method thereof

Abstract

The invention relates to the technical field of organic chemical synthesis, in particular to a 2-sulfonyl aminopyrrole derivative and a preparation method thereof, and the preparation method comprises the following steps: in the presence of a copper compound, performing one-pot reaction on an alpha-amino acetophenone compound as shown in a formula (II), a terminal acetylenic ketone compound as shown in a formula (III) and a sulfonyl azide compound as shown in a formula (IV) to obtain the 2-sulfonyl aminopyrrole derivative. The 2-sulfonyl aminopyrrole derivative as shown in the formula (I) is obtained. A copper compound is used as a catalyst, no oxidizing agent or reducing agent needs to be added, under the promotion of alkali, an alpha-amino acetophenone compound, terminal alkyne ketone and a sulfonyl azide compound are subjected to a one-pot reaction in an organic solvent, and the 2-sulfonyl aminopyrrole derivative which is a diastereoisomer is obtained in one step. The preparation method has the advantages of one-pot reaction, simple and efficient reaction, diversified three-dimensional structure of the product, high yield, wide substrate application range, easiness in separation and purification of the product, good purity and wide industrial application prospect.

Description

Technical Field

[0001] The invention relates to the technical field of organic chemical synthesis, and in particular to a 2-sulfonylaminopyrrole derivative and a preparation method thereof. Background Art

[0002] Pyrrole derivatives are important fine chemical intermediates, widely used in the synthesis of pesticides, medicines, fine chemicals, etc., and have good market prospects. Pyrrole derivatives are the indispensable core structure in the synthesis of barnidipine (barnidipinehydrochloride), a drug for the treatment of hypertension, and are also important intermediates for the synthesis of drugs such as Darifenacin. Sulfonamides are antibacterial and anti-inflammatory pharmacophores, and are also an important class of pharmaceutical intermediates. Summary of the invention

[0003] The problem solved by the present invention is to provide a 2-sulfonylaminopyrrole derivative and a preparation method thereof, which provides a new green synthesis route for the preparation of 2-sulfonylaminopyrrole derivative compounds, and a good yield can be obtained by optimizing conditions.

[0004] In order to achieve the above-mentioned object, the present invention adopts the following technical scheme: a 2-sulfonylaminopyrrole derivative and a preparation method thereof, comprising the following steps: in the presence of a copper compound, reacting an α-aminoacetophenone compound as shown in formula (II), a terminal acetylenic ketone compound as shown in formula (III), and a sulfonyl azide compound as shown in formula (IV) in a one-pot manner to obtain the 2-sulfonylaminopyrrole derivative as shown in formula (I);

[0005]

[0006] Said R1 and R2 are independently selected from H, 4-methylphenyl, 4-halophenyl, 4-hydroxyphenyl, 4-cyanophenyl, 4-methoxyphenyl, 4-nitrophenyl;

[0007] The R3 is selected from any one of C1-C6 alkyl, tert-butyl, cyclopentyl or cyclohexyl;

[0008] The R4 is any one of phenyl, 4-methylphenyl, 4-halogenated phenyl, 4-methoxyphenyl, 4-nitrophenyl, C1-C6 alkyl or halogenated C1-C6 alkyl.

[0009] Preferably, a method for preparing a 2-sulfonylaminopyrrole derivative comprises first reacting a terminal alkynyl ketone compound (III) with a sulfonyl azide compound (IV) under the catalysis of copper to generate a triazole intermediate A, which undergoes a ring-opening rearrangement to obtain an enone imine B, which then undergoes a nucleophilic addition reaction with α-aminoacetophenone (II) to obtain an intermediate C, and then undergoes an intramolecular cyclization reaction under the action of a base to obtain the target product 2-sulfonylaminopyrrole derivative (I). The reaction mechanism is as follows:

[0010]

[0011] After the reaction is completed, the reaction product needs to be subjected to a post-treatment step, and the post-treatment includes any one of extraction, concentration, crystallization, recrystallization, column chromatography purification, or a combination of multiple treatment methods;

[0012] The reaction system is naturally cooled to room temperature, and a mixture of ethyl acetate and saturated brine in an equal volume ratio is added, and the mixture is shaken and extracted for 2-4 times. The organic layer is collected, dried, and concentrated by rotary evaporation to obtain a crude product. The crude product is chromatographed on a 200-300 mesh silica gel column using a mixture of ethyl acetate and petroleum ether as an eluent, wherein the volume ratio of ethyl acetate to petroleum ether is 1:5-10, thereby obtaining the 2-sulfonylaminopyrrole derivative described in formula (I).

[0013] Preferably, the copper compound includes any one or more of copper acetate (Cu(OAc)2), copper chloride (CuCl2), copper bromide (CuBr2), copper acetylacetonate (Cu(acac)2), copper trifluoroacetate (Cu(TFA)2), copper trifluoromethanesulfonate (Cu(OTf)2), copper oxide (CuO), cuprous iodide (CuI), cuprous bromide (CuBr), cuprous chloride (CuCl), copper thiophene-2-carboxylate (CuTc), and cuprous acetate (CuOAc), preferably copper acetate (Cu(OAc)2).

[0014] Preferably, the reaction is carried out in an organic solvent. The organic solvent includes any one or more of acetonitrile, dichloroethane, N,N-dimethylformamide (DMF), N,N-dimethylacetamide (DMA), dichloromethane, chlorobenzene, benzene, xylene, dimethyl sulfoxide (DMSO), and N-methylpyrrolidone (NMP), preferably acetonitrile.

[0015] Preferably, the base includes any one or more of sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, cesium carbonate, sodium ethoxide, triethylamine, and pyridine.

[0016] Preferably, the molar ratio of the compounds (II), (III), (IV) to the copper compound is 1:1-3:1-3:0.05-0.2, for example, 1:1.5:1.5:0.05, 1:2:2:0.1 or 1:3:3:0.2, preferably 1:2:2:0.1; the molar ratio of the α-aminoacetophenone compound (II), the terminal acetylenic ketone compound (III) and the sulfonyl azide compound (IV) is 1:1-3:1-3, for example, 1:1:1, 1:1.5:1.5 or 1:3:3; the molar ratio of the α-aminoacetophenone compound (II) to the base is 1:1-3, for example, 1:1, 1:1.5 or 1:3.

[0017] Preferably, the ratio of the α-aminoacetophenone compound (II) to the solvent is 1 mmol:5-15 mL, for example, 1 mmol:5 mL, 1 mmol:8 mL, 1 mmol:10 mL, 1 mmol:12 mL or 1 mmol:15 mL.

[0018] Preferably, the reaction temperature is 60-120°C, such as 60°C, 80°C, 100°C or 120°C, and the reaction time is 0.5-8 hours, such as 0.5 hours, 1 hour, 2 hours, 4 hours or 8 hours.

[0019] The beneficial effects of the present invention are as follows: by selecting a suitable reaction substrate and reacting under the action of a suitable catalyst, a 2-sulfonylaminopyrrole derivative of formula (I) or (II) is obtained through a one-pot reaction, the reaction conditions are simple, and a good yield is achieved, thereby providing a new green synthetic route for the preparation of 2-sulfonylaminopyrrole derivative compounds, and having good application value and potential in industrial and pharmaceutical synthesis. DETAILED DESCRIPTION

[0020] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0021] Embodiment 1

[0022] A 2-sulfonylaminopyrrole derivative and a preparation method thereof, comprising the following steps: in the presence of a copper compound, reacting an α-aminoacetophenone compound as shown in formula (II), a terminal acetylenic ketone compound as shown in formula (III), and a sulfonyl azide compound as shown in formula (IV) in a one-pot manner to obtain the 2-sulfonylaminopyrrole derivative as shown in formula (I);

[0023]

[0024] Said R1 and R2 are independently selected from H, 4-methylphenyl, 4-halophenyl, 4-hydroxyphenyl, 4-cyanophenyl, 4-methoxyphenyl, 4-nitrophenyl;

[0025] The R3 is selected from any one of C1-C6 alkyl, tert-butyl, cyclopentyl or cyclohexyl;

[0026] The R4 is any one of phenyl, 4-methylphenyl, 4-halogenated phenyl, 4-methoxyphenyl, 4-nitrophenyl, C1-C6 alkyl or halogenated C1-C6 alkyl.

[0027] A preparation method of a 2-sulfonylaminopyrrole derivative, the specific preparation method is:

[0028]

[0029] Add the compounds of the above formula (II), (III), (IV), cuprous iodide (CuI), and cesium carbonate (Cs2CO3) to acetonitrile, then heat to 60°C, and stir and seal the reaction at this temperature for 4 hours;

[0030] The molar ratio of the compound of formula (II) to cuprous iodide (CuI) is 1:0.1; the molar ratio of the compound of formula (II) to the compounds of formula (III) and (IV) is 1:1.5:1.5; the molar ratio of the compound of formula (II) to the base is 1:1.5; the ratio of the compound of formula (II) in millimole (mmol) to acetonitrile in milliliter (ml) is 1:8;

[0031] After the reaction is complete, the reaction system is naturally cooled to room temperature, and a mixture of ethyl acetate and saturated brine in an equal volume ratio is added, and the mixture is shaken and extracted for 2-4 times. The organic layer is collected, dried, and concentrated by rotary evaporation to obtain a crude product. The crude product is chromatographed on a 200-300 mesh silica gel column using a mixture of ethyl acetate and petroleum ether as an eluent, wherein the volume ratio of ethyl acetate to petroleum ether is 1:5, thereby obtaining a white product 2-sulfonylaminopyrrole derivative with a total yield of 95%; a compound of formula (I) (C26H24N2O4S);

[0032] Nuclear magnetic resonance of the compound of formula (I): 1HNMR (400MHz, CDCl3) δ7.78 (s, 1H), 7.48-7.27 (m, 12H), 7.15 (d, J = 6.8Hz, 2H), 6.76 (s, 1H), 3.78 (s, 2H), 2.36 (s, 3H), 1.00 (s, 3H); 13CNMR (100MHz z, CDCl3) δ164.7, 144.0, 138.6, 135.2, 134.4, 129.9, 129.3 (2C), 129.25 (4C), 12 7.8(2C), 127.77(3C), 126.9, 125.5, 125.4(2C), 120.4, 108.2, 60.0, 21.6, 13.9.

[0033] Embodiment 2

[0034] A 2-sulfonylaminopyrrole derivative and a preparation method thereof, comprising the following steps: in the presence of a copper compound, reacting an α-aminoacetophenone compound as shown in formula (II), a terminal acetylenic ketone compound as shown in formula (III), and a sulfonyl azide compound as shown in formula (IV) in a one-pot manner to obtain the 2-sulfonylaminopyrrole derivative as shown in formula (I);

[0035]

[0036] Said R1 and R2 are independently selected from H, 4-methylphenyl, 4-halophenyl, 4-hydroxyphenyl, 4-cyanophenyl, 4-methoxyphenyl, 4-nitrophenyl;

[0037] The R3 is selected from any one of C1-C6 alkyl, tert-butyl, cyclopentyl or cyclohexyl;

[0038] The R4 is any one of phenyl, 4-methylphenyl, 4-halogenated phenyl, 4-methoxyphenyl, 4-nitrophenyl, C1-C6 alkyl or halogenated C1-C6 alkyl.

[0039] A preparation method of a 2-sulfonylaminopyrrole derivative, the specific preparation method is:

[0040]

[0041] Add the compounds of the above formula (II), (III), (IV), cuprous iodide (CuI), and cesium carbonate (Cs2CO3) to dichloromethane, then heat to 80°C and stir and seal the reaction at this temperature for 8 hours;

[0042] Wherein, the molar ratio of the compound of formula (II) to copper acetate (Cu(OAc)2) is 1:0.5; the molar ratio of the compound of formula (II) to the compounds (III) and (IV) is 1:2:2; the molar ratio of the compound of formula (II) to the base is 1:2.0; the ratio of the compound of formula (II) in millimole (mmol) to dichloromethane in milliliter (ml) is 1:10;

[0043] After the reaction is complete, the reaction system is naturally cooled to room temperature, and a mixture of ethyl acetate and saturated brine in an equal volume ratio is added, and the mixture is shaken and extracted for 2-4 times. The organic layer is collected, dried, and concentrated by rotary evaporation to obtain a crude product. The crude product is chromatographed on a 200-300 mesh silica gel column using a mixture of ethyl acetate and petroleum ether as an eluent, wherein the volume ratio of ethyl acetate to petroleum ether is 1:6, thereby obtaining a white product 2-sulfonylaminopyrrole derivative with a total yield of 92%; a compound of formula (I) (C26H23ClN2O4S);

[0044] 1HNMR (400MHz, CDCl3) δ7.80 (s, 1H), 7.40 (s, 6H), 7.32 (s, 5H), 7.17 (s, 2H), 6.7 1 (s, 1H), 3.80 (s, 2H), 2.37 (s, 3H), 1.01 (s, 3H); 13CNMR (100MHz, CDCl3) δ164.6, 144.1, 137.0, 135.2, 134.2, 133.6, 130.0, 129.5(2C), 129.3(2C), 129.2(2C), 12 7.8(2C), 127.77(2C), 127.0, 126.7(2C), 125.8, 120.1, 108.4, 60.1, 21.6, 13.9.

[0045] Embodiment 3

[0046] A 2-sulfonylaminopyrrole derivative and a preparation method thereof, comprising the following steps: in the presence of a copper compound, reacting an α-aminoacetophenone compound as shown in formula (II), a terminal acetylenic ketone compound as shown in formula (III), and a sulfonyl azide compound as shown in formula (IV) in a one-pot manner to obtain the 2-sulfonylaminopyrrole derivative as shown in formula (I);

[0047]

[0048] Said R1 and R2 are independently selected from H, 4-methylphenyl, 4-halophenyl, 4-hydroxyphenyl, 4-cyanophenyl, 4-methoxyphenyl, 4-nitrophenyl;

[0049] The R3 is selected from any one of C1-C6 alkyl, tert-butyl, cyclopentyl or cyclohexyl;

[0050] The R4 is any one of phenyl, 4-methylphenyl, 4-halogenated phenyl, 4-methoxyphenyl, 4-nitrophenyl, C1-C6 alkyl or halogenated C1-C6 alkyl.

[0051] A preparation method of a 2-sulfonylaminopyrrole derivative, the specific preparation method is:

[0052]

[0053] Add the compounds of the above formula (II), (III), (IV), copper acetate (CuOAc)2, and cesium carbonate (Cs2CO3) to DMF, then heat to 100°C, stir and seal to react for 2 hours;

[0054] Wherein, the molar ratio of the compound of formula (II) to cuprous iodide (CuI) is 1:0.15; the molar ratio of the compound of formula (II) to the compounds (III) and (IV) is 1:1.2:1.2; the molar ratio of the compound of formula (II) to the base is 1:1.2; the ratio of the compound of formula (II) in millimole (mmol) to dichloromethane in milliliter (ml) is 1:8;

[0055] After the reaction is complete, the reaction system is naturally cooled to room temperature, and a mixture of ethyl acetate and saturated brine in an equal volume ratio is added, and the mixture is shaken and extracted for 2-4 times. The organic layer is collected, dried, and concentrated by rotary evaporation to obtain a crude product. The crude product is chromatographed on a 200-300 mesh silica gel column using a mixture of ethyl acetate and petroleum ether as an eluent, wherein the volume ratio of ethyl acetate to petroleum ether is 1:8, thereby obtaining a white product 2-sulfonylaminopyrrole derivative with a total yield of 88%; a compound of formula (I) (C27H26N2O4S);

[0056] Nuclear magnetic resonance of compound of formula (I):

[0057] 1HNMR (400MHz, CDCl3) δ7.74 (s, 1H), 7.46 (s, 3H), 7.41 (d, J = 8.0Hz, 3H), 7.36 (s, 1H), 7.23 (d, J =6.4Hz, 2H), 7.13 (s, 4H), 6.72 (s, 1H), 3.78 (d, J = 8.4Hz, 2H), 2.35 (s, 6H), 1.02 (s, 3H); 13CNMR (100MHz, CDCl3) δ164.7, 144.0, 138.6, 136.5, 135.2, 131.4, 129.7, 129.3(2C), 129.2(2C), 129 .1(2C), 128.5(2C), 127.8(2C), 127.7, 125.5, 125.4(2C), 120.2, 108.2, 60.0, 21.6, 21.3, 14.0.

[0058] Embodiment 4

[0059] A 2-sulfonylaminopyrrole derivative and a preparation method thereof, comprising the following steps: in the presence of a copper compound, reacting an α-aminoacetophenone compound as shown in formula (II), a terminal acetylenic ketone compound as shown in formula (III), and a sulfonyl azide compound as shown in formula (IV) in a one-pot manner to obtain the 2-sulfonylaminopyrrole derivative as shown in formula (I);

[0060]

[0061] Said R1 and R2 are independently selected from H, 4-methylphenyl, 4-halophenyl, 4-hydroxyphenyl, 4-cyanophenyl, 4-methoxyphenyl, 4-nitrophenyl;

[0062] The R3 is selected from any one of C1-C6 alkyl, tert-butyl, cyclopentyl or cyclohexyl;

[0063] The R4 is any one of phenyl, 4-methylphenyl, 4-halogenated phenyl, 4-methoxyphenyl, 4-nitrophenyl, C1-C6 alkyl or halogenated C1-C6 alkyl.

[0064] A preparation method of a 2-sulfonylaminopyrrole derivative, the specific preparation method is:

[0065]

[0066] Add the compounds of the above formula (II), (III), (IV), copper acetate (CuOAc)2, and potassium carbonate (K2CO3) to a dimethyl sulfoxide solvent, then heat to 120°C and stir and seal the reaction at this temperature for 12 hours;

[0067] Wherein, the molar ratio of the compound of formula (II) to cuprous iodide (CuI) is 1:0.25; the molar ratio of the compound of formula (II) to the compounds (III) and (IV) is 1:2.0:2.0; the molar ratio of the compound of formula (II) to the base is 1:2.0; the ratio of the compound of formula (II) in millimole (mmol) to dichloromethane in milliliter (ml) is 1:12;

[0068] After the reaction is complete, the reaction system is naturally cooled to room temperature, and a mixture of ethyl acetate and saturated brine in an equal volume ratio is added, and the mixture is shaken and extracted for 2-4 times. The organic layer is collected, dried, and concentrated by rotary evaporation to obtain a crude product. The crude product is chromatographed on a 200-300 mesh silica gel column using a mixture of ethyl acetate and petroleum ether as an eluent, wherein the volume ratio of ethyl acetate to petroleum ether is 1:7, thereby obtaining a white product 2-sulfonylaminopyrrole derivative with a total yield of 86%; a compound of formula (I) (C26H24N2O5S);

[0069] NMR data of compound of formula (I):

[0070] 1HNMR (400MHz, CDCl3) δ7.80 (s, 1H), 7.51-7.48 (m, 7H), 7.42-7.33 (m, 7H), 6.84 ( d, J=7.1Hz, 2H), 6.78 (s, 1H), 3.83 (s, 3H), 1.05 (s, 3H); 13CNMR (100MHz, CDCl3)δ 164.8, 163.4, 138.6, 134.4, 130.1, 130.0(2C), 129.7, 129.3(2C), 129.27(2C), 1 27.7(3C), 126.9, 125.5, 125.4(2C), 120.3, 113.8(2C), 108.2, 60.0, 55.7, 13.9.

[0071] Embodiment 5

[0072] A 2-sulfonylaminopyrrole derivative and a preparation method thereof, comprising the following steps: in the presence of a copper compound, reacting an α-aminoacetophenone compound as shown in formula (II), a terminal acetylenic ketone compound as shown in formula (III), and a sulfonyl azide compound as shown in formula (IV) in a one-pot manner to obtain the 2-sulfonylaminopyrrole derivative as shown in formula (I);

[0073]

[0074] Said R1 and R2 are independently selected from H, 4-methylphenyl, 4-halophenyl, 4-hydroxyphenyl, 4-cyanophenyl, 4-methoxyphenyl, 4-nitrophenyl;

[0075] The R3 is selected from any one of C1-C6 alkyl, tert-butyl, cyclopentyl or cyclohexyl;

[0076] The R4 is any one of phenyl, 4-methylphenyl, 4-halogenated phenyl, 4-methoxyphenyl, 4-nitrophenyl, C1-C6 alkyl or halogenated C1-C6 alkyl.

[0077] A preparation method of a 2-sulfonylaminopyrrole derivative, the specific preparation method is:

[0078]

[0079] Add the compounds of the above formula (II), (III), (IV), cuprous acetate (CuOAc), and potassium carbonate (K2CO3) to a dimethyl sulfoxide solvent, then heat to 100°C and stir and seal the reaction at this temperature for 12 hours;

[0080] Wherein, the molar ratio of the compound of formula (II) to cuprous iodide (CuI) is 1:0.25; the molar ratio of the compound of formula (II) to compounds (III) and (IV) is 1:2.5:2.5; the molar ratio of the compound of formula (II) to the base is 1:2.5; the ratio of the compound of formula (II) in millimole (mmol) to dichloromethane in milliliter (ml) is 1:12;

[0081] After the reaction is complete, the reaction system is naturally cooled to room temperature, and a mixture of ethyl acetate and saturated brine in an equal volume ratio is added, and the mixture is shaken and extracted for 2-4 times. The organic layer is collected, dried, and concentrated by rotary evaporation to obtain a crude product. The crude product is chromatographed on a 200-300 mesh silica gel column using a mixture of ethyl acetate and petroleum ether as an eluent, wherein the volume ratio of ethyl acetate to petroleum ether is 1:7, thereby obtaining a white product 2-sulfonylaminopyrrole derivative with a total yield of 86%; a compound of formula (I) (C28H28N2O4S);

[0082] NMR data of compound of formula (I):

[0083] 1HNMR (400MHz, CDCl3) δ8.13 (s, 1H), 7.53-7.46 (m, 6H), 7.32 (m, 6H), 7.18 (s, 2H), 6.7 (s, 1H), 2.39 (s, 3H), 1.17 (s, 9H); 13CNMR (100MHz, CDCl3) δ164 .4, 143.9, 138.9, 135.4, 135.0, 130.4, 129.6(2C), 129.3(4C), 127.8(2C), 127.6(3C), 126.7, 125.6, 125.2(2C), 120.0, 108.7, 80.9, 28.0(3C), 21.6.

[0084] In summary, it can be clearly seen from all the above embodiments that when the method of the present invention is adopted, the compounds of formula (II), (III), (IV) and compound (V) can react smoothly to obtain the target product with good yield and simple post-treatment. The achievement of these effects depends on the comprehensive synergistic effect of multiple factors such as catalysts and solvents.

[0085] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A 2-sulfonylaminopyrrole derivative and a preparation method thereof, characterized in that: The method comprises the following steps: in the presence of a copper compound, reacting an α-aminoacetophenone compound as shown in formula (II), a terminal acetylenic ketone compound as shown in formula (III), and a sulfonyl azide compound as shown in formula (IV) in a one-pot manner to obtain a 2-sulfonylaminopyrrole derivative as shown in formula (I); Said R1 and R2 are independently selected from H, 4-methylphenyl, 4-halophenyl, 4-hydroxyphenyl, 4-cyanophenyl, 4-methoxyphenyl, 4-nitrophenyl; The R3 is selected from any one of C1-C6 alkyl, tert-butyl, cyclopentyl or cyclohexyl; The R4 is any one of phenyl, 4-methylphenyl, 4-halogenated phenyl, 4-methoxyphenyl, 4-nitrophenyl, C1-C6 alkyl or halogenated C1-C6 alkyl.

2. The method for preparing a 2-sulfonylaminopyrrole derivative according to claim 1, characterized in that: First, the terminal acetyl ketone compound (III) reacts with the sulfonyl azide compound (IV) under the catalysis of copper to generate the intermediate A of triazole, which undergoes ring-opening rearrangement to obtain the enone imine B, which then undergoes nucleophilic addition with α-aminoacetophenone (II) to obtain the intermediate C, and then undergoes intramolecular cyclization reaction under the action of a base to obtain the target product 2-sulfonylaminopyrrole derivative (I). The reaction mechanism is as follows: After the reaction is completed, the reaction product needs to be subjected to a post-treatment step, and the post-treatment includes any one of extraction, concentration, crystallization, recrystallization, column chromatography purification, or a combination of multiple treatment methods; The reaction system is naturally cooled to room temperature, and a mixture of ethyl acetate and saturated brine in an equal volume ratio is added, and the mixture is shaken and extracted for 2-4 times. The organic layer is collected, dried, and concentrated by rotary evaporation to obtain a crude product. The crude product is chromatographed on a 200-300 mesh silica gel column using a mixture of ethyl acetate and petroleum ether as an eluent, wherein the volume ratio of ethyl acetate to petroleum ether is 1:5-10, thereby obtaining the 2-sulfonylaminopyrrole derivative described in formula (I).

3. The method for preparing a 2-sulfonylaminopyrrole derivative according to claim 1, characterized in that: The copper compound includes any one or more of copper acetate, copper chloride, copper bromide, copper acetylacetonate, copper trifluoroacetate, copper trifluoromethanesulfonate, copper oxide, cuprous iodide, cuprous bromide, cuprous chloride, copper thiophene-2-carboxylate, and cuprous acetate.

4. The method for preparing a 2-sulfonylaminopyrrole derivative according to claim 2, characterized in that: The organic solvent includes any one or more of acetonitrile, dichloroethane, N,N-dimethylformamide, N,N-dimethylacetamide, dichloromethane, chlorobenzene, benzene, xylene, dimethyl sulfoxide, and N-methylpyrrolidone.

5. The method for preparing a 2-sulfonylaminopyrrole derivative according to claim 2, characterized in that: The base includes any one or more of sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, cesium carbonate, sodium ethoxide, triethylamine, and pyridine.

6. The method for preparing a 2-sulfonylaminopyrrole derivative according to claim 2, characterized in that: The molar ratio of the compounds (II), (VI), (V) to the copper compound is 1:1-3:1-3:0.05-0.

2.

7. The method for preparing a 2-sulfonylaminopyrrole derivative according to claim 3, characterized in that: The ratio of the α-aminoacetophenone compound to the organic solvent is 1 mmol: 5-15 mL.

8. The method for preparing a 2-sulfonylaminopyrrole derivative according to claim 1, characterized in that: The reaction temperature is 60-120°C.

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