Data acquisition device for lipid nanoparticle preparation system

Abstract

The invention relates to the technical field of data acquisition equipment, in particular to a data acquisition device for a lipid nanoparticle preparation system, which comprises an MCU (Microprogrammed Control Unit), a 10 / 100M adaptive Ethernet communication interface supporting eight channels, an eight-channel isolation RS232 full-duplex communication interface and a six-channel isolation RS485 half-duplex communication interface, the MCU is electrically connected with the Ethernet exchange chip through the Ethernet communication controller to form an eight-channel Ethernet communication interface, and the eight-channel Ethernet communication interface is electrically connected with an upper computer for communication and a plunger pump; the MCU is electrically connected with six paths of RS-485 isolation type transceivers through an asynchronous transceiving transmitter, the six paths of RS-485 isolation type transceivers form six-channel RS485 communication, and any two paths of RS-485 isolation type transceivers are electrically connected with a mass flow meter, a peristaltic pump and a liquid phase direction selection valve; the device is lower in control cost, smaller in integrated space and higher in anti-reverse technology and process confidentiality.

Description

Technical Field

[0001] The invention relates to the technical field of data acquisition equipment, and in particular to a data acquisition device for a lipid nanoparticle preparation system. Background Art

[0002] The lipid nanoparticle preparation system is a system for preparing lipid nanoparticles (LNP), which are mainly used to encapsulate and deliver nucleic acid drugs such as mRNA, siRNA, etc. The lipid nanoparticle preparation system includes several key steps such as the selection of lipid components, the selection of preparation methods, and subsequent characterization and application. For example, the existing lipid nanoparticle preparation system is composed of traditional central control chips, control circuits and information transmission circuits. The traditional PLC control method has higher costs, larger integration space, weaker anti-reverse technology and process confidentiality, making the equipment product less standardized and inconvenient to use.

[0003] Based on the above problems, there is an urgent need for a data acquisition device for a lipid nanoparticle preparation system with lower control cost, smaller integration space, stronger anti-reverse technology and process confidentiality, which can achieve a higher degree of product standardization. Summary of the invention

[0004] In view of the problems of the current traditional PLC control method, such as high cost, larger integration space, weak anti-reverse technology and process confidentiality, the present application provides a data acquisition device for a lipid nanoparticle preparation system to solve the above problems.

[0005] To achieve the above object, the present invention is implemented through the following technical solutions: The present application embodiment discloses a data acquisition device for a lipid nanoparticle preparation system, characterized in that it comprises: MCU, supports 8-channel 10 / 100M adaptive Ethernet communication interface, 8-channel isolated RS232 full-duplex communication interface, and 6-channel isolated RS485 half-duplex communication interface; the MCU is electrically connected to the Ethernet switching chip through the Ethernet communication controller to form an 8-channel Ethernet communication interface, and the 8-way Ethernet communication interface is electrically connected to the host computer communication and the plunger pump; The MCU is electrically connected to 6 RS-485 isolated transceivers through an asynchronous transceiver transmitter, the 6 RS-485 isolated transceivers form a 6-channel RS485 communication, and any two of the RS-485 isolated transceivers are electrically connected to a mass flow meter, a peristaltic pump, and a liquid phase selection valve; The MCU is electrically connected to an SPI signal isolator, and is connected to an 8-way RS-232 transmission channel consisting of four RS-232 transceivers through a serial port expansion; the 8-way RS-232 transmission channel is electrically connected to a weighing system; A plunger pump and a power supply circuit, wherein the power supply circuit is used to supply power to the MCU, the mass flow meter, the weighing system, the plunger pump, the peristaltic pump and the liquid phase selection valve.

[0006] The above technical solution is adopted: the above solution provides a circuit of a data acquisition device for a lipid nanoparticle preparation system, including an MCU, a 6-way RS485 isolated transceiver connected to the MCU, and an 8-way RS32 transmission channel. The core board interface of the present invention is mainly based on serial communication and bus communication, and the interface is reasonably arranged for convenient wiring. The power interface board of the present invention has a smaller space and a higher degree of integration than the traditional electrical wiring, which is convenient for the power supply wiring of all components of the equipment and is equipped with short-circuit protection.

[0007] Preferably, the power supply circuit includes: a 24V voltage input port, a power supply board electrically connected to the 24V voltage input port, a voltage protection circuit electrically connected to the power supply board, a power supply filter electrically connected to the voltage protection circuit, a 24V isolated power supply electrically connected to the power supply filter and an isolated front-end chip power conversion DC-DC LDO, and the 24V isolated power supply is electrically connected to the isolated back-end chip power conversion circuit and the power monitoring chip DC-DC LDO.

[0008] The above technical solution is adopted: the system input power adopts DC24V input, and lightning and surge protection are performed through gas discharge tubes and varistors. The filter circuit composed of 2-level common-mode inductors and capacitors eliminates common-mode interference, conduction and radiation interference of the input power supply, reduces external interference to the 24V input power supply, ensures the stability of the 24V input power supply, and is conducive to improving the stability of the system.

[0009] Further preferably, the 8-channel 10 / 100M adaptive Ethernet communication interface uses an IP1811 industrial-grade network switching chip, supports 8-port 100M + 4-port Gigabit communication interfaces and integrates 8-port 100M PHY, is connected to the RJ45 network port connector through a network transformer, and the IP1811 industrial-grade network switching chip and the MCU use an RMII interface for data transmission.

[0010] Further preferably, the 8-channel RS-232 transmission channel uses a CH9434 chip to expand 8-channel UART serial ports, uses an SP232 chip to convert the serial port level into an RS232 level and provide an external RS232 communication interface, and the RS232 communication interface uses TVS to achieve interface protection against static electricity and surge shock; signal transmission is performed between the CH9434 chip and the MCU through the SPI interface, and signal isolation is achieved between the CH9434 chip and the MCU using a CA-IS3741HB digital isolation chip.

[0011] Further preferably, the 6-channel RS485 communication uses ADM2461 with integrated digital isolation, and the signal interface uses TVS to achieve interface protection against static electricity and surge shock.

[0012] Further preferably, the power supply circuit adopts a DC24V input, performs lightning protection and surge protection through a gas discharge tube and a varistor, and eliminates common-mode interference of the input power supply through a filter circuit composed of a secondary common-mode inductor and capacitor.

[0013] Further preferably, the RS485 communication circuit includes: an RS485 chip, a 3V voltage access terminal and a 5V voltage access terminal electrically connected to the RS485 chip, and a first transient voltage suppression circuit electrically connected to the RS485 chip, wherein the first transient voltage suppression circuit is composed of three transient voltage suppression diodes, and two fuses are also electrically connected to the ends of the transient voltage suppression circuit.

[0014] Further preferably, the RS232 transceiver circuit includes: an RS232 chip, a 3V voltage access terminal electrically connected to the RS232 chip, and a second transient voltage suppression circuit electrically connected to the RS485 chip, the second transient voltage suppression circuit is composed of four transient voltage suppression diodes, the four transient voltage suppression diodes are grounded, and the second transient voltage suppression circuit is also electrically connected to a four-way fuse. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0016] Figure 1 This is a circuit connection block diagram of the data acquisition device of the lipid nanoparticle preparation system of the present application; Figure 2 The power supply circuit diagram for this application; Figure 3 MCU circuit diagram for this application; Figure 4 This is the circuit diagram of the IP1811 industrial-grade network switching chip for this application; Figure 5 This is the circuit diagram of the CH9434 chip for this application; Figure 6 For this application RS485 circuit diagram; Figure 7 RS232 circuit diagram for this application.

[0017] In the figure: 1. MCU; 2. RS485 isolated transceiver; 3. Mass flow meter; 4. Peristaltic pump; 5. Liquid phase selection valve; 6. SPI signal isolator; 7. RS232 transceiver; 8. Weighing system; 9. Plunger pump; 10. Power supply circuit; 11. 24V voltage input port; 12. Power board; 13. Voltage protection circuit; 14. Power filter; 15. 24V isolated power supply; 16. Isolated front-end chip power conversion DC-DC LDO; 17. Isolated back-end chip power conversion circuit; 18. Power monitoring chip DC-DC LDO. DETAILED DESCRIPTION

[0018] In the following description, specific details such as specific system structures, technologies, etc. are provided for the purpose of illustration rather than limitation, so as to provide a thorough understanding of the embodiments of the present application. However, it should be clear to those skilled in the art that the present application may also be implemented in other embodiments without these specific details. In other cases, detailed descriptions of well-known systems, devices, circuits, and methods are omitted to prevent unnecessary details from obstructing the description of the present application.

[0019] It should be understood that when used in the present specification and the appended claims, the term "comprising" indicates the presence of described features, wholes, steps, operations, elements and / or components, but does not exclude the presence or addition of one or more other features, wholes, steps, operations, elements, components and / or combinations thereof.

[0020] See also Figure 1-7 , such as the original data acquisition circuit PLC control mode has high cost, larger integration space, weak anti-reverse technology and process confidentiality, which makes the equipment product less standardized and inconvenient to use. Based on the above problems, the embodiment of the present application discloses a data acquisition device for a lipid nanoparticle preparation system, including: MCU1 supports 8-channel 10 / 100M adaptive Ethernet communication interface, 8-channel isolated RS232 full-duplex communication interface, and 6-channel isolated RS485 half-duplex communication interface; the MCU1 adopts 32bitAMR Cortex M7 embedded MCU1, and can also be replaced by STM32H753 or STM32H7 series MCU1 of the same type.

[0021] The MCU is electrically connected to the Ethernet switching chip through an Ethernet communication controller to form an 8-way Ethernet communication interface, and the 8-way Ethernet communication interface is electrically connected to the host computer communication and the plunger pump; the MCU is electrically connected to a 6-way RS-485 isolated transceiver through an asynchronous transceiver transmitter, and the 6-way RS-485 isolated transceiver forms a 6-channel RS485 communication.

[0022] The 8-channel 10 / 100M adaptive Ethernet communication interface uses the IP1811 industrial-grade network switching chip, supports 8-port 100M + 4-port Gigabit communication interfaces, integrates 8-port 100M PHY, and connects to the RJ45 network port connector through a network transformer. The RMII interface is used for data transmission between IP1811 and MCU1.

[0023] See also Figure 5 , the MCU1 is electrically connected to 6 RS485 isolated transceivers 2 through an asynchronous transceiver transmitter, the 6 RS485 isolated transceivers 2 form a 6-channel RS485 communication, and any two of the RS485 isolated transceivers 2 are electrically connected to a mass flow meter 3, a peristaltic pump 4 and a liquid phase selection valve 5; See also Figure 7 , 8-channel RS232 uses CH9434 chip to expand 8-way UART serial port, uses SP232 chip to convert serial port level to RS232 level to provide external interface, RS232 communication interface uses TVS to achieve anti-static and surge protection. Signal transmission between CH9434 and MCU1 is carried out through SPI interface, and signal isolation is achieved between CH9434 and MCU1 using CA-IS3741HB digital isolation chip.

[0024] The MCU1 is electrically connected to an SPI signal isolator 6, and is connected to an 8-way RS232 transmission channel consisting of four RS232 transceiver 7 circuits through a serial port expansion; the 8-way RS232 transmission channel is electrically connected to a weighing system 8; The plunger pump 9 and the power supply circuit 10 are used to supply power to the MCU 1 , the mass flow meter 3 , the weighing system 8 , the plunger pump 9 , the peristaltic pump 4 and the liquid phase selection valve 5 .

[0025] The above scheme provides a circuit for a data acquisition device for a lipid nanoparticle preparation system, including an MCU1, a 6-way RS485 isolated transceiver 2 connected to the MCU1, and an 8-way RS32 transmission channel. The core board interface of the present invention is mainly based on serial communication and bus communication, and the interface is reasonably arranged for convenient wiring. The power interface board of the present invention has a smaller space and a higher degree of integration than traditional electrical wiring, is convenient for power supply wiring of all components of the device, and is equipped with short-circuit protection.

[0026] See also Figure 1 and Figure 2The power supply circuit 10 includes: a 24V voltage input port 11, a power board 12 electrically connected to the 24V voltage input port 11, a voltage protection circuit 13 electrically connected to the power board 12, a power filter 14 electrically connected to the voltage protection circuit 13, a 24V isolated power supply 15 electrically connected to the power filter 14 and an isolated front-end chip power conversion DC-DC LDO 16, and the 24V isolated power supply 15 is electrically connected to an isolated back-end chip power conversion circuit 17 and a power monitoring chip DC-DC LDO 18. The voltage protection circuit 13 includes: +24V input voltage, overvoltage, overcurrent, reverse connection protection, surge protection and soft start.

[0027] The system input power adopts DC24V input, and is protected against lightning and surges through gas discharge tubes and varistors. The filter circuit composed of 2-level common-mode inductors and capacitors eliminates the common-mode interference, conduction and radiation interference of the input power supply, reduces external interference to the 24V input power supply, ensures the stability of the 24V input power supply, and is conducive to improving the stability of the system.

[0028] The system power supply has overvoltage, overcurrent, undervoltage and reverse connection protection function modules, and each function module uses an electronic fuse chip to independently protect each other. The SOC core circuit module uses an isolated power supply to prevent external interface abnormalities from affecting the core module.

[0029] The 8-channel 10 / 100M adaptive Ethernet communication interface uses the IP1811 industrial-grade network switching chip, supports 8-port 100M + 4-port Gigabit communication interfaces, integrates 8-port 100M PHY, connects to the RJ45 network port connector through a network transformer, and uses the RMII interface for data transmission between the IP1811 industrial-grade network switching chip and MCU1. The 8-channel 100M network switching chip IP1811 can be replaced by RTL8310B or other chips with 8-channel 100M network interfaces.

[0030] The 8-way RS232 transmission channel uses the CH9434 chip to expand the 8-way UART serial port, uses the SP232 chip to convert the serial port level to the RS232 level and provide an external RS232 communication interface, and the RS232 communication interface uses TVS to achieve interface protection against static electricity and surge impact; the CH9434 chip and MCU1 transmit signals through the SPI interface, and the CA-IS3741HB digital isolation chip is used between the CH9434 chip and the MCU1 to achieve signal isolation. The serial port expansion chip CH9434 can be replaced by WK2124 or other 4-channel SPI to UART chips.

[0031] The 6-channel RS485 communication circuit uses the ADM2461 with integrated digital isolation, and the signal interface uses TVS to achieve interface protection against static electricity and surge shock.

[0032] The RS485 interface can use an independent digital isolation IC or an optocoupler + RS485 chip to replace the existing RS485 interface solution with integrated digital isolation.

[0033] The power supply circuit 10 uses a DC 24V input, and is protected against lightning and surges by a gas discharge tube and a varistor, and eliminates common-mode interference of the input power supply through a filter circuit composed of a secondary common-mode inductor and capacitor.

[0034] The RS485 communication circuit includes: an RS485 chip, a 3V voltage access terminal and a 5V voltage access terminal electrically connected to the RS485 chip, and a first transient voltage suppression circuit electrically connected to the RS485 chip, wherein the first transient voltage suppression circuit is composed of three transient voltage suppression diodes, and two fuses are also electrically connected to the ends of the transient voltage suppression circuit.

[0035] The RS232 transceiver 7 circuit includes: an RS232 chip, a 3V voltage access terminal of the RS232 chip electrically connected to the RS232 chip using an SP3232EEN-L / TR chip, and a second transient voltage suppression circuit electrically connected to the RS485 chip, the second transient voltage suppression circuit is composed of four transient voltage suppression diodes, the four transient voltage suppression diodes are grounded, and the second transient voltage suppression circuit is also electrically connected to a four-way fuse.

[0036] This device can achieve better matching with the use of the biopharmaceutical industry. The core board interface of the present invention is mainly based on serial communication and bus communication, and the interface layout is reasonable and convenient for wiring. Compared with traditional electrical wiring, the power interface board of the present invention has a smaller space and higher integration, which is convenient for power supply wiring of all components of the equipment and equipped with short-circuit protection.

[0037] Unless otherwise specified, the device components involved in the above embodiments are all conventional device components, and the connection methods and control methods involved are all conventional connection methods and control methods unless otherwise specified.

[0038] The present invention has been described in detail above in conjunction with the embodiments. However, those skilled in the art will appreciate that, without departing from the spirit of the present invention, the specific parameters in the above embodiments may be changed to form a plurality of specific embodiments, which are all within the common variation range of the present invention and will not be described in detail herein.

Claims

1. A data acquisition device for a lipid nanoparticle preparation system, characterized in that: include: MCU, supports 8-channel 10 / 100M adaptive Ethernet communication interface, 8-channel isolated RS232 full-duplex communication interface, and 6-channel isolated RS485 half-duplex communication interface; the MCU is electrically connected to the Ethernet switching chip through the Ethernet communication controller to form an 8-channel Ethernet communication interface, and the 8-way Ethernet communication interface is electrically connected to the host computer communication and the plunger pump; The MCU is electrically connected to 6 RS-485 isolated transceivers through an asynchronous transceiver transmitter, the 6 RS-485 isolated transceivers form a 6-channel RS485 communication, and any two of the RS-485 isolated transceivers are electrically connected to a mass flow meter, a peristaltic pump, and a liquid phase selection valve; The MCU is electrically connected to an SPI signal isolator, and is connected to an 8-way RS-232 transmission channel consisting of four RS-232 transceivers through a serial port expansion; the 8-way RS-232 transmission channel is electrically connected to a weighing system; A plunger pump and a power supply circuit, wherein the power supply circuit is used to supply power to the MCU, the mass flow meter, the weighing system, the plunger pump, the peristaltic pump and the liquid phase selection valve.

2. A data acquisition device for a lipid nanoparticle preparation system according to claim 1, characterized in that: The power supply circuit includes: a 24V voltage input port, a power supply board electrically connected to the 24V voltage input port, a voltage protection circuit electrically connected to the power supply board, a power supply filter electrically connected to the voltage protection circuit, a 24V isolated power supply electrically connected to the power supply filter and an isolated front-end chip power conversion DC-DC LDO, and the 24V isolated power supply is electrically connected to the isolated back-end chip power conversion circuit and the power monitoring chip DC-DC LDO.

3. A data acquisition device for a lipid nanoparticle preparation system according to claim 1, characterized in that: The 8-channel 10 / 100M adaptive Ethernet communication interface uses an IP1811 industrial-grade network switching chip, supports 8-port 100M + 4-port Gigabit communication interfaces and integrates 8-port 100M PHY, is connected to the RJ45 network port connector through a network transformer, and the IP1811 industrial-grade network switching chip and the MCU use the RMII interface for data transmission.

4. A data acquisition device for a lipid nanoparticle preparation system according to claim 1, characterized in that: The 8-channel RS-232 transmission channel uses the CH9434 chip to expand the 8-channel UART serial port, uses the SP232 chip to convert the serial port level into the RS232 level and provides an external RS232 communication interface, and the RS232 communication interface uses TVS to achieve interface protection against static electricity and surge shock; the CH9434 chip and the MCU transmit signals through the SPI interface, and the CA-IS3741HB digital isolation chip is used between the CH9434 chip and the MCU to achieve signal isolation.

5. A data acquisition device for a lipid nanoparticle preparation system according to claim 1, characterized in that: The 6-channel RS485 communication uses the ADM2461 with integrated digital isolation, and the signal interface uses TVS to achieve interface protection against static electricity and surge shock.

6. A data acquisition device for a lipid nanoparticle preparation system according to claim 2, characterized in that: The power supply circuit adopts DC24V input, and is protected against lightning and surge by gas discharge tubes and varistors, and the common-mode interference of the input power supply is eliminated by a filter circuit composed of secondary common-mode inductors and capacitors.

7. A data acquisition device for a lipid nanoparticle preparation system according to claim 1, characterized in that: The RS485 communication circuit includes: an RS485 chip, a 3V voltage access terminal and a 5V voltage access terminal electrically connected to the RS485 chip, and a first transient voltage suppression circuit electrically connected to the RS485 chip, wherein the first transient voltage suppression circuit is composed of three transient voltage suppression diodes, and two fuses are also electrically connected to the ends of the transient voltage suppression circuit.

8. A data acquisition device for a lipid nanoparticle preparation system according to claim 1, characterized in that: The RS232 transceiver circuit includes: an RS232 chip, a 3V voltage access terminal electrically connected to the RS232 chip, and a second transient voltage suppression circuit electrically connected to the RS485 chip, wherein the second transient voltage suppression circuit is composed of four transient voltage suppression diodes, the four transient voltage suppression diodes are grounded, and the second transient voltage suppression circuit is also electrically connected to a four-way fuse.

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