Light irradiation system, light irradiation method, light measurement method, and light measurement device

Abstract

Provided are a light irradiation system, a light irradiation method, a light measurement method, and a light measurement device that are advantageous for activation of OPN5 present in the retina of a person. The problem is solved by a light irradiation system configured so as to be provided with one or more light sources that irradiate light having a wavelength in a wavelength region that overlaps the peak wavelength of an OPN5 absorption spectrum, the light irradiation system adjusts one or more selected from among an installation position of the light source, an irradiation direction of the light, a wavelength range of the light, an irradiance of the light, an irradiation period of the light, and an irradiation time of the light. Furthermore, the problem can be solved by a light irradiation system comprising a light irradiation unit provided with the one or more light sources, and a light measurement unit provided with the one or more light sources. The light measuring unit measures spectral data of the light and compares the spectral data of the light with the OPN5 absorption spectrum data, and the light irradiation system adjusts the installation position and the like of the light source on the basis of the result of the comparison.

Description

Technical Field

[0001] The present invention relates to a light irradiation system, a light irradiation method, a light measurement method, and a light measurement device. Background Art

[0002] In recent years, the effects of light on the human body have been studied from various viewpoints, and reports based on new insights have been made. For example, it has been reported that: circadian rhythms can be improved by basking in sunlight (non-patent document 1), light emitted from LED lighting, liquid crystal displays using LEDs as backlights, etc., can have a great impact on the body and mood (non-patent document 2), and violet light can prevent myopia and inhibit the onset of myopia (patent document 1), etc. In particular, recently, the inventors have reported on the effects of violet light on myopia, for example, in patent document 1 and non-patent document 3, it is proposed that light of a specific wavelength has the effect of preventing or inhibiting the progression of myopia, and in recent years, as the number of people with myopia continues to increase worldwide, it has been highly anticipated.

[0003] Opsin 5 (OPN5) is known as a photoreceptor protein, and research has been conducted on visual functions and non-visual functions of humans and animals (Non-Patent Document 4).

[0004] Prior art literature

[0005] Non-patent literature

[0006] Non-patent literature 1: Hatori Kei, Tsuboda Kazuo, Amano·Essue Medicine-Journal of the Japanese Anti-Targeting Medical Association, Vol.11, No.3, 065(385)-072(392), (2015).

[0007] Non-patent document 2: Kazuo Tsuboda, "The Threat of the Timepiece in the Body of Furuta", Shueisha, published on November 20, 2013.

[0008] Non-patent literature 3: Hidemasa Torii et al., EBioMedicine, "DOI: http: / / dx.doi.org / 10.1016 / j.ebiom.2016.12.007".

[0009] Non-patent document 4: Takahiro Yamashita, "New regulation of ultraviolet photoreceptivity of vertebrates - Ultraviolet photoreceptor? -", Biophysics, 51(4), 186-187(2011).

[0010] Patent Literature

[0011] Patent document 1: WO2015 / 186723A1 Summary of the invention

[0012] Problem that the invention aims to solve

[0013] like Figure 1 As shown, OPN5 shows an absorption spectrum having a peak at 380 nm. If such OPN5 can be activated, it is expected that the relationship with visual function and non-visual function and the relationship with the inhibition of myopia progression studied by the present inventors will be clarified.

[0014] The present invention has been made to solve the above-mentioned problems, and an object of the present invention is to provide a light irradiation system, a light irradiation method, a light measurement method, and a light measurement device.

[0015] Solutions for solving problems

[0016] (1) The light irradiation system (first light irradiation system) involved in the present invention is characterized in that it has one or more light sources, and the one or more light sources irradiate light of a wavelength in a wavelength region overlapping with the peak wavelength of the absorption spectrum of visual protein 5, i.e., the absorption spectrum of OPN5, and the light irradiation system adjusts one or more selected from the setting position of the light source, the irradiation direction of the light, the wavelength range of the light, the irradiance of the light, the irradiation time period of the light, and the irradiation time of the light.

[0017] According to the first light irradiation system, the light source can be adjusted according to any of the above, so that the irradiated object is irradiated with light of a wavelength region overlapping with the peak wavelength of the absorption spectrum of OPN5. As a result, it is advantageous for activating OPN5 present in the retina of a person as the irradiated object.

[0018] (2) The light irradiation system (second light irradiation system) involved in the present invention is characterized in that it has one or more light sources, and the one or more light sources irradiate light with a wavelength in a wavelength region overlapping with the peak wavelength of the absorption spectrum of opsin 5, that is, the absorption spectrum of OPN5, and the unit of the spectrum of the light received by the irradiated body is W / m 2 The effective spectral irradiance of the light received by the sensor is adjusted to W / m 2 / nm, wherein the effective spectral irradiance of the received light is calculated as W / m at each wavelength in the wavelength range of 280nm to 500nm of the light. 2 The reference effective spectral irradiance is calculated as the product of the spectral irradiance of 100 nm / nm and the relative absorbance of the OPN5 absorption spectrum data at each wavelength. The unit of the reference effective spectral irradiance is W / m 2 The product of the spectral irradiance of / nm and the relative absorbance of the OPN5 absorption spectrum at each wavelength.

[0019] According to the second light irradiation system, the spectrum of light received by the irradiated body is adjusted so that the effective spectrum irradiance of the received light is 0.2% or more of the reference effective spectrum irradiance. As a result, it is beneficial for the activation of OPN5 present in the retina of the person who is the irradiated body. The light that becomes the proportion within the above range is calculated based on the spectrum of light measured at the irradiated body or the peripheral position of the irradiated body.

[0020] (3) The light irradiation system (third light irradiation system) involved in the present invention is characterized in that it is composed of a light irradiation unit and a light measuring unit, wherein the light irradiation unit has one or more light sources, and the one or more light sources irradiate light of a wavelength in a wavelength region overlapping with a peak wavelength of an absorption spectrum of visual protein 5, i.e., an OPN5 absorption spectrum, and the light measuring unit measures spectral data of the light and compares the spectral data of the light with the OPN5 absorption spectrum data, and the light irradiation system adjusts one or more selected from the setting position of the light source, the irradiation direction of the light, the wavelength range of the light, the irradiance of the light, the irradiation time period of the light, and the irradiation time of the light based on the result obtained by the comparison.

[0021] According to the third light irradiation system, the installation position of the light source, the irradiation direction of the light, the wavelength range of the light, the irradiance, the irradiation time period or the irradiation time are adjusted based on the result obtained by the comparison in the light measurement method. As a result, it is advantageous for activating OPN5 present in the retina of a person as an irradiated body.

[0022] In the first light irradiation system to the third light irradiation system, it is preferred that the light is light including 380 nm as the peak wavelength of the absorption spectrum of the OPN5, and it is more preferred that the light is light having a wavelength of 400 nm or less or 410 nm or less. In addition, since light having a wavelength of 400 nm or less or 410 nm or less is light having a low relative luminous efficiency, even if the light is composed only of wavelengths of 400 nm or less or includes wavelengths of 400 nm or more or 410 nm, and the spectral irradiance or irradiance in its wavelength region is lower than the spectral irradiance or irradiance in the wavelength region of 400 nm or less or less, this light is advantageous in that it can be irradiated toward a person for a long time.

[0023] In the first light irradiation system to the third light irradiation system, the light source is configured at one or more positions selected from the following positions: a position where the light is irradiated toward an irradiated body as an irradiation object; a position where the light enters the field of view of the irradiated body; a position in the line of sight direction from the side of the irradiated body; a position where the light is irradiated toward the irradiated body as diffused light after being diffused by a diffuse material; and a position where the light is irradiated toward the irradiated body as reflected light after being reflected by a reflective material.

[0024] In the first to third light irradiation systems, (i) when the light source is arranged at a position to irradiate the light toward the irradiated body, the irradiance of the light is adjusted by using the distance and / or angle from the light source to the irradiated body; (ii) when the light source is arranged at a position to enter the field of view of the irradiated body or a position in the line of sight direction viewed from the side of the irradiated body, the irradiance of the light is adjusted by using the distance and / or angle from the light source to the irradiated body; (iii) when the light source is arranged at a position to irradiate the irradiated body as diffused light after being diffused by the diffuser, the irradiance of the light is adjusted by using the distance and / or angle from the light source and the diffuser to the irradiated body, or the diffusion angle and / or transmittance of the diffuser; (iv) when the light source is arranged at a position to irradiate the irradiated body as reflected light after being reflected by the reflector, the irradiance of the light is adjusted by using the distance and / or angle from the light source and the reflector to the irradiated body, or the reflection angle and / or reflectivity of the reflector.

[0025] In the first to third light irradiation systems, the light source is selected from a structure-mounted light source, a setting-mounted light source, a built-in or mounted light source, a body-mounted tool-mounted light source, and a functional device-mounted light source. The structure-mounted light source is installed on the ground, wall, ceiling, or other structures, wherein the ground also includes the ground under the feet, and the ceiling also includes hanging objects. The setting-mounted light source is installed on a desk, dining table, partition, shelf, table component, personal computer, display, PC keyboard, television, stereo, or other equipment or setting, wherein , the partition is a partition wall or a screen, the built-in or installed light source is a built-in or installed light source of a portable personal computer, a tablet computer, a smart phone or other portable terminals, the body-mounted tool-mounted light source is installed on or detachably installed as an accessory on a vision correction tool, an eye protection tool, a face protection tool, a neck-hanging tool, an ear-hanging tool, a head-mounted tool or other body-mounted tool, and the functional device-mounted light source is installed on a functional device for AR, VR or MR, wherein the functional device is goggles, headphones or other functional devices.

[0026] In the first light irradiation system to the third light irradiation system, the direction or position of the light source is adjusted manually or automatically.

[0027] In the third light irradiation system, the unit of calculation is W / m, which is the product of the spectrum data of the light and the absorption spectrum data of the OPN5 at each wavelength. 2 / nm effective spectral irradiance of light received.

[0028] In the third light irradiation system, the unit of each wavelength of the sunlight spectrum specified by AM1.5G is calculated as W / m 2 The unit is W / m 2 / nm, and the unit is W / m 2 / nm benchmark effective spectral irradiance and the unit is W / m 2 / nm is used for comparison of the effective spectral irradiance of the light received.

[0029] In the third light irradiation system, the spectrum data of the light is compared in all or part of the wavelength region of the OPN5 absorption spectrum. In the present application, "all" refers to the wavelength region in the range of 280nm to 500nm, and "part" refers to a wavelength region arbitrarily determined from the whole wavelength region, for example, the wavelength region in the range of 360nm to 400nm, 370nm to 390nm, etc.

[0030] In the third light irradiation system, when the comparison is made in the wavelength region, the unit W / m 2 / nm is obtained by integrating the effective spectral irradiance of the light received to obtain the unit of W / m 2 The effective irradiance of the light received is W / m 2 / nm is integrated to obtain the unit of W / m 2 The obtained effective irradiance of received light is compared with the reference effective irradiance. This comparison is useful for quantitative evaluation of changes in the body caused by light absorption by OPN5 present in the human retina.

[0031] In the third light irradiation system, the unit is W / m 2 The unit is J / m, which is obtained by multiplying the effective irradiance of the light by the exposure time in seconds. 2 The effective dose of light is W / m 2 The unit is J / m2 This comparison is useful for quantitative evaluation of changes in the body caused by light absorption by OPN5 present in the human retina.

[0032] In the third light irradiation system, the measurement is performed by a measuring unit, which is arranged on glasses, headphones, watches, badges or other items worn on the body based on the way the light source irradiates the light, or is worn on the body itself, or is installed on a setting near or around the body.

[0033] (4) The light irradiation method according to the present invention is characterized in that the light is irradiated from one or more light sources that irradiate the light of a wavelength region overlapping with the peak wavelength of the opsin 5 absorption spectrum, i.e., OPN5 absorption spectrum, to the irradiated body, and the spectrum data of the light received by the irradiated light is compared with the OPN5 absorption spectrum data, and the irradiation conditions of the light are adjusted based on the comparison result, wherein the irradiation conditions of the light are one or more conditions selected from the setting position of the light source, the irradiation direction of the light, the wavelength range of the light, the irradiance of the light, the irradiation time period of the light, and the irradiation time of the light. The present invention is a working scheme for adjusting the conditions of the irradiation light, and the irradiated light is adjusted based on the comparison between the spectrum data of the received light and the OPN5 absorption spectrum data, and therefore, it is advantageous for activating OPN5 present in the retina of a person as the irradiated body.

[0034] The light irradiation method further includes a light measurement scheme, in which the spectrum data of the light is measured and compared with the OPN5 absorption spectrum data. In the light irradiation method, the unit of the product of the spectrum data of the light and the OPN5 absorption spectrum data for each wavelength is calculated as W / m 2 / nm effective spectral irradiance of light received.

[0035] (5) The light measurement method involved in the present invention is characterized in that spectral data of light with a wavelength in a wavelength region overlapping with the peak wavelength of the visual protein 5 absorption spectrum, i.e., the OPN5 absorption spectrum, is measured, and the measured spectral data of the light is compared with the pre-stored OPN5 absorption spectrum data, and the comparison result is displayed on a display device or output as data.

[0036] According to the present invention, the spectral data of the received light is measured, and the measured spectral data of the light is compared with the pre-stored known OPN5 absorption spectral data. Therefore, by evaluating the obtained comparison results, it is possible to help clarify the relationship between light irradiation and visual function and non-visual function (including the relationship with the inhibition of myopia progression).

[0037] In the optical measurement method, the comparison is performed by a calculation unit, in which the unit of the calculation is W / m, which is a product of the spectrum data of the light and the absorption spectrum data of the OPN5 for each wavelength. 2 / nm effective spectral irradiance of light received.

[0038] In this light measurement method, the unit of calculation of the sunlight spectrum specified by AM1.5G is W / m 2 The unit is W / m 2 / nm, and the unit is W / m 2 / nm benchmark effective spectral irradiance and the unit is W / m 2 / nm is used for comparison of the effective spectral irradiance of the light received.

[0039] According to the present invention, the degree (for example, ratio: %) of the actual effective spectral irradiance of light received relative to the common reference effective spectral irradiance can be generally evaluated regardless of the measurement area and measurement time. As a result, the result obtained by comparison can be used to objectively evaluate whether light irradiation is related to the effect on the body.

[0040] In the optical measurement method, the spectrum data of the light are compared in the entire or a part of the wavelength region of the OPN5 absorption spectrum.

[0041] According to the present invention, even when the received light contains various spectral data, it is compared with all or part of the wavelength regions of the OPN5 absorption spectrum, so it can also be applied to the case where the wavelength region of the light is determined using a filter or the like. As a result, it can be used as a measurement method for clarifying whether the effect of the body that has changed due to light irradiation is related to the effective spectral irradiance of the light received in the entire wavelength region of the OPN5 absorption spectrum, or the effective spectral irradiance of the light received in a specific wavelength region of the OPN5 absorption spectrum. In addition, as the determination of the wavelength region of the light using a filter or the like, it can also be determined as a specific wavelength region such as the wavelength region of 360nm to 400nm of purple light, so it can also be used to verify the detailed effect of the determined wavelength region, etc. In the present application, "all" is set to the wavelength region in the range of 280nm to 500nm, and "part" is set to a wavelength region arbitrarily determined from the entire wavelength region, for example, a wavelength region in the range of 360nm to 400nm, 370nm to 390nm, etc.

[0042] In the light measurement method, when the comparison is made in the wavelength region, the effective spectral irradiance of the received light is integrated in the wavelength region to obtain the value in W / m 2 The effective irradiance of the received light is calculated by integrating the reference effective spectral irradiance in the same wavelength region to obtain the value in W / m 2 The obtained effective irradiance of the received light is compared with the reference effective irradiance.

[0043] In this light measurement method, the unit is W / m 2 The unit is J / m, which is obtained by multiplying the effective irradiance of the light by the exposure time in seconds. 2 The effective dose of light is W / m 2 The unit is J / m 2 This comparison is useful for quantitative evaluation of changes in the body caused by light absorption by OPN5 present in the human retina.

[0044] In the optical measurement method, the measurement is performed by a measurement unit, which is provided on glasses, headphones, a watch, a badge or other articles worn on the body, or is worn on the body itself, or is installed on an object installed near or around the body, based on the manner of the light source irradiating the light. According to the present invention, the installation in the above manner is arbitrarily selected and set based on the installation manner of the light source irradiating the light (light source manner, installation position of the light source, etc.), so it is not easy to become an obstacle, and it is easy to measure the spectrum data of the light received by the eyes and the body.

[0045] (6) The light measuring device involved in the present invention is characterized in that it has a measuring unit that measures spectral data of light with a wavelength in a wavelength region overlapping with a peak wavelength of the visual protein 5 absorption spectrum, i.e., the OPN5 absorption spectrum, and the light measuring device compares the spectral data of the light measured by the measuring unit with the OPN5 absorption spectrum data stored in advance, and displays the result of the comparison on a display device or outputs it as data.

[0046] The present invention is a device for implementing the above-mentioned light measurement method (5), wherein at least the measuring unit among the measuring unit, the computing unit, and the output unit is built into the light measurement device, but the computing unit and the output unit may be built into the light measurement device or may not be built into the device but be provided by an external device or equipment.

[0047] Effects of the Invention

[0048] According to the first light irradiation system of the present invention, the light source can be adjusted so that the irradiated object is irradiated with light of a wavelength in a wavelength region overlapping with the peak wavelength of the absorption spectrum of OPN5. As a result, it is advantageous for activating OPN5 present in the retina of a person serving as the irradiated object.

[0049] According to the second light irradiation system of the present invention, the irradiated object can be irradiated with light having a calculated effective spectral irradiance of 0.2% or more of the reference effective spectral irradiance, which is advantageous for activating OPN5 in the retina of a person serving as the irradiated object.

[0050] According to the third light irradiation system involved in the present invention, the installation position of the light source, the irradiation direction of the light, the wavelength range of the light, the irradiance, the irradiation time period or the irradiation time are adjusted based on the result obtained by the comparison in the light measurement method. As a result, it is advantageous for activating OPN5 existing in the retina of a person as an irradiated body.

[0051] According to the light irradiation method involved in the present invention, the irradiated light is adjusted based on the comparison between the spectral data of the light received and the OPN5 absorption spectral data, which is beneficial for activating the OPN5 existing in the retina of the person serving as the irradiated body.

[0052] According to the light measurement method and light measurement device involved in the present invention, the spectral data of the received light is measured, and the spectral data of the measured light is compared with the known OPN5 absorption spectrum data stored in advance. Therefore, by evaluating the obtained comparison results, it is possible to expect the relationship between light irradiation and visual function and non-visual function (including the relationship with the inhibition of myopia progression). This comparison result can be used as basic data for evaluating the relationship between the received light and the activation of OPN5, and in particular, it can be calculated and digitized based on the degree of overlap between the spectral data of the measured light and the known OPN5 absorption spectrum data, so it can be used for objective evaluation of whether light irradiation is related to the effect on the body. BRIEF DESCRIPTION OF THE DRAWINGS

[0053] Figure 1 is the absorbance of the OPN5 absorption spectrum (dimensionless).

[0054] Figure 2 These are the absorption spectra of OPN5, OPN4, rhodopsin (Rh), and three photoreceptins (S, M, L).

[0055] Figure 3 The relative luminous efficiency of the photopic standard at each wavelength (upper graph) and the color of light (lower graph).

[0056] Figure 4 This is an example of a violet light LED having an irradiation wavelength range of 360 nm to 400 nm.

[0057] Figure 5 (A) is an example of a light source that irradiates light in a wide wavelength range including a wavelength exceeding 400 nm. Figure 5 (B) is an example in which the wavelength range of the irradiated light is limited to 360nm to 400nm by using a shielding filter. Figure 5 (C) is an explanatory diagram showing the overlap between the irradiation light limited in the above (B) and the absorption spectrum of OPN5.

[0058] Figure 6 This is an example of how light sources are set up in a spacious office space.

[0059] Figure 7 This is an example of setting up light sources in homes and offices.

[0060] Figure 8 This is an installation example of a desktop light source on a desk or a personal computer installation light source.

[0061] Fig. 9 (A) is the absorbance of the OPN5 absorption spectrum (dimensionless), Fig. 9 (B) is the spectral irradiance (intensity of light received at the position of the eye) of a violet LED having a peak at 375 nm, Fig. 9 (C) is the effective spectral irradiance of the light received, which is composed of the product of the two at each wavelength.

[0062] Fig.10 (A) is the absorbance of the OPN5 absorption spectrum (dimensionless), (B) is the spectral irradiance of a wide-area light source emitting light above 300nm (the intensity of light received at the position of the eye), and (C) is the effective spectral irradiance of received light, which is the product of the two at each wavelength.

[0063] Fig.11 (A) is the absorbance of the OPN5 absorption spectrum (dimensionless), Fig.11 (B) is the spectral irradiance of the sunlight spectrum specified by AM1.5G, Fig.11 (C) is the benchmark effective spectral irradiance composed of the product of the two at each wavelength.

[0064] Fig.12 Yes Fig.11 The reference effective spectral irradiance (reference symbol b) shown in (C) is Fig. 9 A graph comparing the effective spectral irradiance of the light received (reference numeral a) shown in (C).

[0065] Fig.13 It is a schematic diagram showing an example of a light measurement method and a light measurement device. DETAILED DESCRIPTION

[0066] Hereinafter, the light irradiation system, light irradiation method, light measurement method and light measurement device according to the present invention will be described with reference to the drawings. The present invention is not limited to the following embodiments as long as it includes the gist described in this application, and can be modified in various forms.

[0067] (1) The light irradiation system (first light irradiation system) involved in the present invention is characterized in that it has one or more light sources, and the one or more light sources irradiate light of a wavelength in a wavelength region overlapping with the peak wavelength of the absorption spectrum of visual protein 5, i.e., the absorption spectrum of OPN5, and the light irradiation system adjusts one or more selected from the setting position of the light source, the irradiation direction of the light, the wavelength range of the light, the irradiance of the light, the irradiation time period of the light, and the irradiation time of the light.

[0068] (2) The light irradiation system (second light irradiation system) involved in the present invention is characterized in that it has one or more light sources, and the one or more light sources irradiate light with a wavelength in a wavelength region overlapping with the peak wavelength of the absorption spectrum of opsin 5, that is, the absorption spectrum of OPN5, and the unit of the spectrum of the light received by the irradiated body is W / m 2 The effective spectral irradiance of the light received by the sensor is adjusted to W / m 2 / nm, wherein the effective spectral irradiance of the received light is calculated as W / m at each wavelength in the wavelength range of 280nm to 500nm of the light. 2 The reference effective spectral irradiance is calculated as the product of the spectral irradiance of 100 nm / nm and the relative absorbance of the OPN5 absorption spectrum data at each wavelength. The unit of the reference effective spectral irradiance is W / m 2 The product of the spectral irradiance of / nm and the relative absorbance of the OPN5 absorption spectrum at each wavelength.

[0069] (3) The light irradiation system (third light irradiation system) involved in the present invention is characterized in that it is composed of a light irradiation unit and a light measuring unit, wherein the light irradiation unit has one or more light sources, and the one or more light sources irradiate light of a wavelength in a wavelength region overlapping with a peak wavelength of an absorption spectrum of visual protein 5, i.e., an OPN5 absorption spectrum, and the light measuring unit measures spectral data of the light and compares the spectral data of the light with the OPN5 absorption spectrum data, and the light irradiation system adjusts one or more selected from the setting position of the light source, the irradiation direction of the light, the wavelength range of the light, the irradiance of the light, the irradiation time period of the light, and the irradiation time of the light based on the result obtained by the comparison.

[0070] (4) The light irradiation method involved in the present invention is characterized in that the light is irradiated from one or more light sources that irradiate light of a wavelength region overlapping with the peak wavelength of the visual protein 5 absorption spectrum, i.e., the OPN5 absorption spectrum, to the irradiated object, and the spectrum data of the light received by the irradiated light is compared with the OPN5 absorption spectrum data, and the irradiation conditions of the light are adjusted based on the result of the comparison, wherein the irradiation conditions of the light are one or more conditions selected from the setting position of the light source, the irradiation direction of the light, the wavelength range of the light, the irradiance of the light, the irradiation time period of the light, and the irradiation time of the light.

[0071] (5) The light measurement method involved in the present invention is characterized in that spectral data of light with a wavelength in a wavelength region overlapping with the peak wavelength of the visual protein 5 absorption spectrum, i.e., the OPN5 absorption spectrum, is measured, and the measured spectral data of the light is compared with the pre-stored OPN5 absorption spectrum data, and the comparison result is displayed on a display device or output as data.

[0072] (6) The light measuring device involved in the present invention is characterized in that it has a measuring unit that measures spectral data of light with a wavelength in a wavelength region overlapping with a peak wavelength of the visual protein 5 absorption spectrum, i.e., the OPN5 absorption spectrum, and the light measuring device compares the spectral data of the light measured by the measuring unit with the OPN5 absorption spectrum data stored in advance, and displays the result of the comparison on a display device or outputs it as data.

[0073] [Each component]

[0074] Hereinafter, each component constituting each of the above-mentioned inventions will be described in detail. In addition, each component is related to each invention, and therefore, the components will be described sequentially instead of in the order of the inventions.

[0075] [OPN5, OPN5 absorption spectrum]

[0076] OPN5 (opsin 5) is a light receptor protein found in the human retina. Figure 1 As shown, OPN5 shows an absorption spectrum with a peak at 380 nm. In the present invention, "OPN5 absorption spectrum" is defined as Figure 1 The absorption spectrum of OPN5 is shown. Figure 1 From "Kojima D, Mori S, Torii M, Wada A, Morishita R, et al. (2011) UV-Sensitive Photoreceptor Protein OPN5 in Humans and Mice. PLoS ONE 6(10): e26388. doi: 10.1371 / journal.pone.0026388" Figure 5 The figure cited in A is understood as a standard figure by those skilled in the art at the time of filing this application. In addition, the reference also clearly states that the OPN5 absorption spectrum has an absorption peak at 380nm, and is understood by those skilled in the art. Through the irradiation of light in the present invention, it can be expected that OPN5 present in the retina of a person as the irradiated body will be activated, and it can be expected that visual function and non-visual function will be improved, myopia progression will be suppressed, etc. will be achieved, and those studies will be explored and developed. In addition, Figure 2is the absorption spectrum of OPN5, OPN4, rhodopsin (Rh) and three photoreceptins (S, M, L). This is also recorded in the aforementioned reference by Kojima et al. Figure 5 A. OPN5 is also located in the lowest wavelength region among them.

[0077] Regarding the absorption spectrum of OPN5, when the absorbance at the peak of 380nm is set to 1, Figure 1 As shown, the following absorption spectrum is shown: the wavelength range with absorbance of 0.1 or more is about 300nm to 440nm, the wavelength range with absorbance of 0.5 or more is about 340nm to 420nm, the wavelength range with absorbance of 0.7 or more is about 350nm to 410nm, and the wavelength range with absorbance of 0.8 or more is about 360nm to 400nm. For OPN5 having such absorbance characteristics, it is preferable to irradiate light showing a high absorbance of 0.5 or more, 0.7 or more, or 0.8 or more from the viewpoint of activation of OPN5.

[0078] [Light source, light irradiation unit, light irradiation method]

[0079] <Light>

[0080] In the present invention, the light irradiated from the light source or the light received by the irradiated object includes light of a wavelength region overlapping with the peak wavelength of the OPN5 absorption spectrum. The peak wavelength of the OPN5 absorption spectrum is 380nm as mentioned above. Here, "light of a wavelength region overlapping with the peak wavelength" means light of a wavelength region including Figure 1 The light in the wavelength region of the peak wavelength (380 nm) in the OPN5 absorption spectrum shown in FIG. Figure 1 The light in the wavelength region that overlaps with the entire wavelength region of about 270nm to 460nm shown in all wavelength regions may also be the light in the wavelength region that overlaps with a portion of the wavelength region. As described above, the “partial wavelength region” refers to, for example, a wavelength range with an absorbance of 0.1 or more (about 300nm to 440nm), a wavelength range with an absorbance of 0.5 or more (about 340nm to 420nm), a wavelength range with an absorbance of 0.7 or more (about 350nm to 410nm), a wavelength range with an absorbance of 0.8 or more (about 360nm to 400nm), etc., which do not overlap with the entire wavelength region of the absorption spectrum of OPN5 (about 270nm to 460nm) but only include the peak wavelength (380nm).

[0081] In addition, as "light in a wavelength region including the peak wavelength (380nm) of the absorption spectrum of OPN5", for example, it may also be light in a wavelength range of ±20nm including the peak wavelength (380nm) of the absorption spectrum of OPN5 or light that partially overlaps. This means that, although it is more preferred that the irradiated light is light having a peak in a wavelength range of ±20nm of 380nm, it may also be light in a wavelength region that does not have a peak but emits light in this range. In addition, "light including..." refers to light irradiated with a wavelength of 360nm to 400nm including ±20nm of 380nm, and "light that partially overlaps" refers to light that overlaps at least 380nm, for example, a wavelength region including 370nm to 400nm, 360nm to 390nm, 365nm to 395nm, etc. In addition, the inventors refer to light in a wavelength range of 360nm to 400nm as violet light, and therefore, the light in these wavelength ranges is sometimes referred to as violet light for explanation below.

[0082] “Being illuminated” means that the light emitted from a light source is illuminated to a person as an illuminated object. As a method of being illuminated, the light source may be directed toward the illuminated object as an illuminated object and the light emitted from the light source is directly illuminated to the illuminated object, or the light emitted from a light source that is in the field of vision of the person as the illuminated object or in the direction of sight from the side of the illuminated object is illuminated to the illuminated object, or the light emitted from the light source is not directed toward the illuminated object but is illuminated to the illuminated object as diffuse light or reflected light. “Received light” means light received by a person as an illuminated object. The irradiance and absorption spectrum of the received light are measured by a measuring device installed at a person or a peripheral position of the person. In addition, in the present application, the illuminated object and the person or the person's eye have the same meaning and can be replaced with each other.

[0083] (Wavelength range of light)

[0084] Since it is believed that light with a wavelength less than 315nm has an adverse effect on the human eye, the lower limit wavelength of light is preferably 340nm, 350nm or 360nm. Which wavelength is set as the lower limit depends on the irradiance of the light in the lower limit region. Therefore, if the irradiance of light near the lower limit is small, it can also be less than 340nm. However, it is preferred to use 340nm, 350nm or 360nm as the lower limit range of light, and it is more preferred to use 350nm or 360nm as the lower limit range of light. In addition, Figure 1In the absorption spectrum of OPN5 shown, the absorbance is greater than 0.5 in the wavelength range of about 340nm to 420nm, the absorbance is greater than 0.7 in the wavelength range of about 350nm to 410nm, and the absorbance is greater than 0.8 in the wavelength range of about 360nm to 400nm. Therefore, by adopting a light source that irradiates light in the wavelength range of about 340nm to 420nm, the wavelength range of about 350nm to 410nm, or the wavelength range of about 360nm to 400nm, it can help to activate OPN5.

[0085] Preferably, the light is light of a wavelength whose upper limit wavelength is below 400nm or below 410nm. Light of such a wavelength is light with relatively low luminous efficiency. Light with relatively low luminous efficiency is non-glaring light. "Non-glaring light" refers to light that is not glaring to a person as the irradiated object. Even if irradiated with such light, the person will not feel the glare or will not easily feel the glare. Therefore, it is advantageous in that long-term irradiation toward a person can be performed. Regarding "irradiation with light of a wavelength of below 400nm or below 410nm with low luminous efficiency", the case of irradiating light from a light source that does not radiate or substantially does not radiate light exceeding 400nm or exceeding 410nm can be cited. As such a light source, particularly preferred is violet light of 360nm to 400nm or light of 350nm to 410nm. In addition, when light is irradiated from a light source having a filter that blocks light with a wavelength exceeding 400nm or exceeding 410nm, or when light with a wavelength exceeding 400nm or exceeding 410nm is radiated, light with a wavelength below 400nm or below 410nm can also be irradiated.

[0086] Regarding relative luminous efficiency, for example, "Masanori Takase, Katsunori Okajima, Eiji Uchikawa, Mitsuo Ikeda, 'Changes in the Brightness of Colored Light in Direct Comparison', Optics, Vol. 19 (No. 3), published in 1990" records that relative luminous efficiency can be measured by direct comparison method, flicker photometry, stepwise brightness matching method, MDB method, absolute threshold method, etc., and that the CIE standard relative luminous efficiency is mainly calculated by flicker photometry. Generally speaking, relative luminous efficiency is evaluated by direct comparison method and flicker photometry. In addition, in Appendix 8 of "https: / / elaws.e-gov.go.jp / download?law_unique_id=404M50000400080_20161001_0000000000000000&file_type=PDF_H1", data on relative luminous efficiency (spectral luminous efficiency) are listed. The relative luminous efficiency (relative luminous efficiency in bright places) is obtained by standardization using light with a wavelength of 555nm (green light). According to the table, for example, a relative luminous efficiency of less than 0.01 refers to a wavelength region less than 430nm on the short wavelength side. In this way, people feel that green light is the brightest, and the feeling of brightness will weaken regardless of whether the wavelength increases or decreases compared to it. The relative luminous efficiency is a value in which the brightness of a wavelength of 555nm is set to 1 and a comparative value is used to represent the brightness of other wavelengths with the same energy. Figure 3 The figure shows the relative light efficiency of the photopic vision standard. In fact, there are individual differences in the degree to which people perceive non-glaring light, so it is difficult to generalize. Figure 3 The relative value of the vertical axis shown in the figure is used to determine the degree of value, but the light with a wavelength of less than 400nm or less than 410nm is a lower wavelength than the wavelength region less than 430nm where the relative luminous efficiency is less than 0.01, so the relative luminous efficiency is smaller, and can be called a relative luminous efficiency of at least less than 0.01. The light with a wavelength of less than 400nm or less than 410nm, which is an extremely small value of relative luminous efficiency, can be said to be less dazzling than the light in other wavelength regions where the relative luminous efficiency exceeds 0.01 regardless of individual differences. As a result, it is advantageous in that a person can be irradiated or irradiated for a long time without causing the person to feel the irradiated light. In addition, in the present application, the irradiated body and the person or the person's eyes have the same meaning and can therefore be replaced with each other.

[0087] <Light source>

[0088] The light source is not particularly limited as long as it is a light source that irradiates light in the above wavelength range. "Light irradiating the wavelength range" may be a light source whose own emission spectrum has the above wavelength range (e.g., light of 360nm to 400nm, 350nm to 410nm), or a light source whose own emission spectrum exceeds the upper limit of the above wavelength range but irradiates within the above wavelength range through a shielding filter. In addition, the following may be used: Figure 4 As shown in FIG. 1 , a light source that does not radiate or substantially does not radiate light with a wavelength exceeding 400 nm (e.g., a violet LED light source having a peak wavelength at 375 nm) may also be used for Figure 5 As shown in (A) of FIG. 1 , a light source that irradiates light in a wide wavelength range including a wavelength exceeding 400 nm is provided. Figure 5 The light source is shielded by the filter shown in (B). In addition, Figure 5 (B) is an example of a light source in which the wavelength range of the irradiated light is limited to 360nm to 400nm by a shielding filter. Figure 5 (C) is an explanatory diagram showing overlap between the light emitted from the light source and the absorption spectrum of OPN5.

[0089] For example, light of 360nm to 400nm and 350nm to 410nm overlaps with the absorption spectrum of OPN5 having a peak at 380nm, and has a low relative luminous efficiency and is not dazzling. Therefore, even if the light is irradiated to the human eye as direct light, diffuse light, or reflected light, there is less to worry about. For example, it is advantageous in that light can activate OPN5 present in the human retina.

[0090] In addition, in the case of irradiating light toward the eyes of a person as the irradiated object, it is desirable to use a light source that emits only non-glaring light of 400nm or less or 410nm. However, in the case of a light source configured not to irradiate light toward the eyes of a person, it may be a light source that includes light of 400nm or less or 410nm and also includes light of a wavelength exceeding 400nm or 410nm (white light, etc.), or it may be a light source obtained by combining a light source of 400nm or less or 410nm with a light source emitting light of wavelengths other than these.

[0091] The light emitted from the light source may be either a constant light or a flashing light. In the case of a flashing light, the flashing light may be continuously irradiated or may be irradiated at intervals of several seconds, tens of seconds, or several minutes.

[0092] <How to install the light source>

[0093] One or more light sources are provided. Regarding the light source, it is selected from a structure-mounted light source, a setting-mounted light source, a built-in or mounted light source, a body-mounted tool-mounted light source, and a functional device-mounted light source. The structure-mounted light source is installed on the ground (including under the feet), a wall, a ceiling (including hanging objects), and other structures. The setting-mounted light source is installed on a desk, a dining table, a partition (partition wall, screen), a shelf, a table component, a personal computer, a display, a PC keyboard, a television, a stereo, other equipment or a setting. The built-in or mounted light source is a built-in or mounted light source of a portable personal computer, a tablet, a smart phone, or other portable terminals. The body-mounted tool-mounted light source is installed or removably installed as an accessory on a vision correction tool, an eye protection tool, a face protection tool, a neck hanging tool, an ear hanging tool, a head-mounted tool, or other body-mounted tools. The functional device-mounted light source is installed on a functional device for AR, VR, or MR (goggles, headphones, and other functional devices). The light source is built into or installed in a structure, equipment, installation, portable terminal, body-mounted tool, functional device, etc. depending on its form, and can irradiate the light emitted from the light source to a person as direct light, as diffuse light, or as reflected light.

[0094] As such a light source mode, it can be a setting-mounted light source, which is directly installed in public buildings or shared buildings such as residences, school buildings, government buildings, company office buildings, gymnasiums, etc., such as ordinary families, and buildings that are covered by roofs but have no walls, or it can be a setting-mounted light source installed on furniture or settings. In addition, it can also be a portable light source that can be assembled on portable terminals such as portable personal computers, tablets, and smart phones that people can carry. In addition, it can also be a wearable light source installed on wearable devices such as vision correction equipment, eye protection equipment, facial protection equipment, neck hanging equipment, ear hanging equipment, head installation equipment, etc. In addition, with respect to wearable light sources that people can wear, it can also be a glasses-wearing light source with a light source installed on glasses that people can wear regardless of whether they have a vision correction function, an accessory light source that can be loaded and unloaded relative to such glasses, and a light source installed on a goggle-type device for functional use, AR, VR, or MR.

[0095] Figure 6 to Figure 8 This is an example of light source settings. Figure 6 This is an example of how light sources are set up in a spacious office space. Figure 7 This is an example of how to set up light sources in homes and offices. Figure 8 Examples of such light sources include a desktop light source on a desk and a light source installed on a personal computer. As such, light sources can be installed in various ways.

[0096] "One or more light sources" means that the light source is one or more light sources selected from the above-mentioned various light sources (set-type light sources, body-mounted tool-type light sources, functional device-set-type light sources). When there is one light source, it is desirable to configure it so that the light emitted from the light source is directed toward the eyes.

[0097] As a specific setting method of the setting type light source, for example Figure 6 , Figure 7 As shown, when the direction of the sight line does not change much, such as when the person is mainly doing desk work in an office, or studying and working in a school, a study room, or a home, it is desirable to arrange the setting light source 10 in front of the sight line, and adjust the direction of the setting light source 10 so as to emit light in the direction D of the eyes. Figure 6 , Figure 7 In the embodiment, the light source 10 is arranged at a position that enters the visual field or the direction of the visual line, so the light source 10 can also be arranged at such a position. In addition, even if the light source 10 is not directed toward a person, the light source 10 can be arranged at a position where the light source 10 can be reflected by the diffusion material or the reflection material 11 (see Figure 6 and Figure 7 ) to irradiate light to the position of the eye (for example, a position outside the field of vision or in a direction other than the line of sight). In this way, one or more light sources 10 can be set at various positions. Figure 6 and Figure 7 In the example of a set-up type light source in which the light source 10 is mainly set on a wall, a hanging object hanging from a ceiling, a desk, a dining table, the ground (including under the feet), etc., the light source 10 may be set on other structures, or on a partition (partition wall, screen), a shelf, a table member, or other set-up objects. In addition, it is desirable that Figure 8 As shown, the light source 10 is set at a position that enters the field of vision, a position in the direction of sight, such as a position on the frame of a display or an extension line thereof, or a position around the keyboard of a personal computer in such a way that the orientation of the set-type light source 10 is adjusted.

[0098] In addition, in Figure 7As shown in the figure, when the direction of sight line in the workplace, family etc. may change, it is desirable to configure more than 2 multiple setting type light sources 10, and adjust the position and direction of the light source 10 to emit light towards the direction of eyes as much as possible. For example, when sitting on a chair, a sofa, it is desirable to configure the setting type light source 10 at the height of eyes as much as possible, and the light source is set to be in the direction towards eyes as much as possible at this height. In addition, it is also the same when the situation of standing is more, it is desirable to configure the setting type light source 10 at the height of eyes as much as possible, and the light source is set to be in the direction towards eyes as much as possible at this height. In addition, when sitting down sometimes and standing sometimes, it is desirable to set the setting type light source 10 in a mode that satisfies both parties, and the setting type light source 10 is set to be in the direction towards eyes as much as possible at each height.

[0099] For example, non-glaring light such as light with a wavelength of about 400nm or less is usually difficult to be reflected by walls and the ground, so it is desirable that the light source is arranged at a position where the light is directly irradiated toward the irradiated object. On the other hand, even if the light is not directly irradiated toward the irradiated object, it is possible to a) arrange the light source at a position that enters the field of vision of the irradiated object or at a position in the direction of sight from the side of the irradiated object, b) arrange the light source at a position where the irradiated object is irradiated as diffused light after being diffused by a diffuser, or c) appropriately set a special reflective material that reflects light with a wavelength of less than 400nm, and arrange the light source at a position where the irradiated object is irradiated as reflected light after being reflected by such a reflective material. For example, in desk work, it is desirable to set the light source at a position directly in front of the eyes of the person who is the irradiated object, at a position in the field of vision, or at a position in the direction of sight. However, even if it is impossible or difficult to set it at those positions, it is preferable to set a diffuser or a reflector, and diffuse or reflect the light through the diffuser or the reflector so that the diffused light or the reflected light is irradiated toward the eyes of the person who is the irradiated object. Preferably, one or more of these units are combined to irradiate light toward the human eye. As the diffusion material, it is possible to select from various diffusion materials according to the diffusion angle characteristics and transmittance characteristics, and as the reflective material, a special reflective material that reflects the aforementioned light that is difficult to reflect is made into a fixed type, a mobile type, or a portable type for use, thereby having the advantage of increasing the degree of freedom of the location where the light source is installed.

[0100] It is preferred that the setting type light source is set in advance in the direction of the eye, in the position entering the field of vision, or in the position in the direction of the line of sight. In addition, it is also possible to adjust the direction or position of the setting position of the light source manually or automatically, or to adjust the angle of the light emitted from the light source manually or automatically. By adjusting the direction or position of the light source manually or automatically, the direction and position of direct irradiation or reflected irradiation toward the irradiated body can be arbitrarily changed. As a result, effective activation of OPN5 can be expected. "Adjusting the direction" means adjusting by arbitrarily rotating in the three-dimensional X, Y, and Z directions, and "adjusting the position" means adjusting by arbitrarily moving in the three-dimensional X, Y, and Z directions. "Manually operating" can be exemplified by, for example, an angle adjustment adapter that can fine-tune the mounting platform of the light source in the up and down direction, up and down tilt direction, left and right rotation direction, etc., such as a camera adjustment adapter. "Automatically operating" can be exemplified by the situation where the aforementioned angle adjustment adapter can be automatically adjusted by motor drive. In addition, the following cases can be exemplified: when it is operated manually, the operator performs it manually, but when it is operated automatically, the angle adjustment adapter is provided with a CCD camera or the like to detect the position of the irradiated object and then automatically adjusted by a motor drive. In addition, it is also effective to have a tracking system in the light source that detects the eyes of a person or detects the movement of a person to perform irradiation. It is also effective to swing the light source in various directions or to use a light source with a large directional angle of light emission. In addition, when using a diffuse material or a reflective material, adjustments such as changing the position of the light source can be made, and adjustments can also be made by changing the type of the diffuse material, the setting angle of the reflective material, etc.

[0101] Regarding the portable terminal setting type light source, for example, there can be listed light sources installed in portable terminals such as portable personal computers, tablets, and smart phones, but it can also be a light source that can be worn on portable terminals other than these. The portable terminal setting type light source is also similar to the setting type light source, and it is preferred that the direction of the light is pre-set to the direction of the eyes, etc. In addition, similar to the above-mentioned setting type light source, the setting position of the light source can be changed manually or automatically, or the angle of the light emitted from the light source can be changed manually or automatically. Similar to the above, it is effective to have a tracking system in the light source, and it is also effective to swing the light source in various directions or use a light source with a large directional angle of light emission.

[0102] Regarding body-mounted tool-type light sources, there can be listed accessory light sources that are mounted on or detachably mounted on vision correction tools, eye protection tools, face protection tools, neck hanging tools, ear hanging tools, head-mounted tools, etc., but as long as they can be worn on the body, light sources other than these are also possible. As with the above-mentioned light sources, the body-mounted tool-type light source is also preferably set in advance to the direction of the eyes, etc. The distance between the body-mounted tool-type light source and the eyes is short, so there is no need to change the setting position compared to the above-mentioned light sources, but it can also be changed manually or automatically as needed, or the angle of the light emitted from the light source can be changed manually or automatically.

[0103] The functional device setting type light source is a light source installed in functional devices (goggles, headphones, etc.) for AR, VR, and MR, but it can also be a light source that can be worn on devices other than them. The functional device setting type light source is at a short distance from the eyes like the above-mentioned body-mounted tool type light source, so there is no need to change the setting position compared to the above-mentioned light sources, but it can also be changed manually or automatically as needed, or the angle of light emitted from the light source can be changed manually or automatically.

[0104] <Irradiation method>

[0105] The light emitted from the light source is irradiated toward the person, and it is particularly preferred that the light is irradiated toward the eyes. "Irradiated" means that the light emitted from the light source is irradiated toward the person. The light source can be directed toward the person and the light emitted from the light source is directly irradiated toward the person, or the light emitted from the light source at a position entering the field of vision or in the direction of the line of sight is irradiated toward the person, or the light source is not directed toward the person but the light emitted from the light source is irradiated toward the person as diffuse light or reflected light. "Directly or after reflection" means that the light source can be directly irradiated toward the person (preferably the eyes) or can be irradiated after being reflected by a reflective material. In addition, "direct irradiation" also includes making the light diffused by a diffuse material and irradiating the diffuse light toward the eyes. In addition, as mentioned above, the direction or position of the light source can also be adjusted manually or automatically, so the way of irradiating the light toward the person directly or after reflection and efficiently can be changed arbitrarily.

[0106] In this light irradiation method, it is preferred that: (i) when the light source is set at a position to irradiate light toward the irradiated body, the irradiance of the light is adjusted by using the distance and / or angle from the light source to the irradiated body; (ii) when the light source is set at a position entering the field of view of the irradiated body or in the direction of the line of sight viewed from the side of the irradiated body, the irradiance of the light is adjusted by using the distance and / or angle from the light source to the irradiated body; (iii) when the light source is set at a position to irradiate the irradiated body as diffused light after being diffused by a diffuse material, the irradiance of the light is adjusted by using the distance and / or angle from the light source and the diffuse material to the irradiated body, or the diffusion angle and / or transmittance of the diffuse material; (iv) when the light source is set at a position to irradiate the irradiated body as reflected light after being reflected by a reflective material, the irradiance of the light is adjusted by using the distance and / or angle from the light source and the reflective material to the irradiated body, or the reflection angle and / or reflectivity of the reflective material. By adjusting the irradiance of light using each of the above methods (i) to (iv), it is possible to allow light of an irradiance required for activating OPN5 to reach a person.

[0107] (Reflective material)

[0108] The reflective material is a member that reflects the light irradiated in the present invention in a specific direction. For example, light with a wavelength of 400 nm or less or 410 nm or less will not be reflected by the reflective material that reflects ordinary white light. Therefore, by providing a special reflective material that reflects light with a wavelength of 400 nm or less or less or less than 410 nm, even if such light is not irradiated directly toward a person or cannot be irradiated directly due to the reasons for the setting, it can be irradiated toward a person after being reflected by the reflective material.

[0109] In the case where the light source cannot be placed at a position where it can directly irradiate light toward the eyes due to the installation conditions of the light source, the above-mentioned special reflective material can be placed at an appropriate position so that the reflected light can be irradiated toward the eyes. Figure 6 In the desk work shown, when it is desired to set the light source 10 in front of the eyes but it is not possible to set the light source in front of the eyes, it is preferred to set a reflective material 11 in front of the eyes to reflect the light toward the eyes. Figure 6 The reflective material denoted by reference numeral 11 is an example of a reflective material that reflects light from a light source suspended from a ceiling toward the eyes. As the reflective material, for example, a fixed, mobile, or portable reflective material is used, which has the advantage of increasing the degree of freedom of the location where the light source is installed. As described above, although it is desirable that the light source is installed at a position where the light emitted from the light source is directly irradiated to the eyes, in other cases, it is preferable to utilize the reflective material to irradiate light toward the eyes.

[0110] Resist ink can be applied to a plate or wall to provide a reflective material. Specifically, for example, a highly reflective white resist ink made by Okamoto Glass Co., Ltd. can be cited. The reflective material formed by applying the white resist ink to a thickness of 20 μm on a glass substrate is 69 μm / cm thick at a distance of 10 cm from the reflective material. 2 In an experiment where NSPU510CS (cannonball-type LED, peak wavelength: 375nm) manufactured by Nichia Chemical Corporation was irradiated with an irradiance of , the reflectivity could be increased by about 2.9 times.

[0111] (Directivity)

[0112] Regarding the directivity of light, it is particularly desirable to set the light source or to set a diffusing material or a reflecting material in a manner that allows the light to reach the direction of the face (line of sight). The height of the light source is also an important factor. For example, it is preferable to set the light source at a position based on the movement pattern in the office or home and adjust the height and direction of the light source. As a solution for improving the directivity, it is preferable to set the light source in a manner that allows the light emitted from the light source to directly reach the eyes, or to set the light source in a position that enters the field of vision or in the direction of the line of sight in a manner that allows the light emitted from the light source to easily reach the eyes. For example, in the case where the change in the line of sight axis is relatively small (for example Figure 6 , Figure 8 In the desk work as shown in FIG. 1 , it is preferably arranged at a position irradiated at an angle of 30° or less relative to the imaginary sight line of the person. In this way, light can be irradiated to the eyes of the person being irradiated.

[0113] In addition, regarding the diffusion material, since there are diffusion materials having characteristic diffusion angle characteristics and transmittance characteristics on the market, it is possible to select from various diffusion materials according to these characteristics.

[0114] [Optical measurement method, optical measurement unit]

[0115] Next, the light measurement method and the light measurement unit are described. The light measurement method and the light measurement unit have different categories, but have the same meaning, so they are sometimes referred to as the light measurement unit below. The light measurement unit may also include the light irradiation system involved in the present invention.

[0116] In the present invention, it is preferred to have a light measuring unit that measures the spectral data of light received by a person as an irradiated body after being irradiated from a light source, and compares the spectral data of the light with the absorption spectral data of OPN5. In this way, the spectral data of the received light can be measured by the light measuring unit, and the spectral data of the measured light can be compared with the known absorption spectral data of OPN5 stored in advance. Therefore, by studying the obtained comparison results (also referred to as comparison data), it is possible to help clarify the relationship between light irradiation and visual function and non-visual function (including the relationship with the inhibition of myopia progression). The obtained comparison results can be used as basic data for studying and evaluating the relationship between the received light and the activation of OPN5, and in particular, can be compared and digitized based on the degree of overlap between the spectral data of the measured light and the known absorption spectral data of OPN5, so it can be used for objective evaluation of whether light irradiation is related to the effect on the body. By using this utilization, for example, it can be used to evaluate whether light of what wavelength range is effective at what degree of irradiance, in what time period, and for what degree of time, based on the relationship with the effect of OPN5 on the body.

[0117] In addition, based on the obtained comparison result, when the light cannot be sufficiently irradiated to the irradiated body, one or more conditions selected from the setting position of the light source, the irradiation direction of the light, the wavelength range of the light, the irradiance of the light, the irradiation time period of the light, and the irradiation time of the light can be adjusted. As a result, it is advantageous for the activation of OPN5 present in the retina of the person who is the irradiated body. In addition, the "spectral data of light" is the spectral data of light measured by the measuring unit set at the position of the eye of the irradiated body or the peripheral position of the eye. The light measuring unit constituting the system can be configured in the system as a whole with the above-mentioned light irradiation unit, or can be independently configured in a separate place with the help of a communication unit. In addition, the measurement of the light measuring unit is performed in the system, but the comparison can also be independently displayed in a separate place with the help of a communication unit or performed by comparison operation. The independent light measuring unit only needs to perform measurement and comparison at each time of measurement and comparison and display the result for adjusting the light irradiation. When a calculation unit is provided for comparison, the measuring unit and the calculation unit may be always arranged in the system to perform measurement and comparison always or when necessary, or may be arranged in the system when necessary to perform measurement and comparison when necessary.

[0118] In addition, the "light" in "spectral data of received light" is not limited to light emitted from a light source, but refers to the spectral data of light measured including all light from other than the light source, but mainly refers to the spectral data of light emitted from the light source indoors. In addition, the light measuring unit is preferably capable of measuring light entering a person's eyes with high accuracy, and is particularly preferably worn on a person or mounted on a wearing member worn on a person. The comparison is performed by a computing unit, but such a computing unit may be built into the light measuring method, or may be sent to an external computing unit that is not built into the light measuring method.

[0119] The result obtained by comparison can be displayed on a display device or output as data. The part that performs such display or output can also be set as an output unit. In addition, it can also be called a display unit. The output unit is also similar to the above-mentioned operation unit, and can be configured in the same system or device, or can be independently configured in a separate place with the help of a communication unit. The independent output unit only needs to output the result obtained by comparison (display or data output), and can be always configured in the system and output at all times or when necessary, or can be configured in the system when necessary and output when necessary.

[0120] As an example of a light measuring unit, Fig.13 As shown in FIG. 1 , the optical measurement unit 21 is characterized by comprising: a measurement unit 22 for measuring received optical spectrum data; and a calculation unit 23 for comparing the optical spectrum data with OPN5 absorption spectrum data. Fig.13 As shown, a memory 24 and a display unit 25 may also be provided. The memory 24 stores OPN5 absorption spectrum data, etc. The display unit 25 is used to display the comparison result, and is also called an output unit. The comparison in the calculation unit 23 is used to include the case where only comparison is performed and displayed or output, and the case where the compared data is calculated and displayed or output.

[0121] The light measuring unit 21 can measure the received light spectrum data through the measuring unit 22, and compare the measured light spectrum data with the OPN5 absorption spectrum data through the internal or external calculation unit 23. Therefore, by studying the obtained comparison results, it can help to clarify the relationship between light irradiation and visual function and non-visual function (including the relationship with the inhibition of myopia progression). In particular, by comparing and calculating the overlap between the measured light spectrum data and the pre-stored OPN5 absorption spectrum data and digitizing them, it can be used to evaluate the objectivity of the effect of the body obtained by OPN5. With this utilization, for example, it can be used to evaluate whether light of what wavelength range is effective at what degree of irradiance, in what time period, and for what degree of time, based on the relationship with the effect of OPN5 on the body. In addition, the light in the "received light spectrum data" is not limited to the light from the light source in the above-mentioned light irradiation method, but refers to the light spectrum data including all the measured light. In addition, the light measuring method is preferably capable of measuring the light entering the human eye with high precision, and is particularly preferably worn on the human body or installed on a wearing member worn on the human body.

[0122] like Fig. 9 and Fig.10 As shown in the figure, the calculation unit calculates the product of the light spectrum data at each wavelength and the OPN5 absorption spectrum data at each wavelength as the effective spectral irradiance (W / m 2 / nm). In this way, the effective spectral irradiance (W / m 2 / nm) as evaluation data, and therefore, can be used as a measuring device for clarifying the objective relationship between the obtained evaluation data and the physical effect obtained by OPN5.

[0123] In addition, in the operation part, if Fig.11 As shown, the spectral irradiance (W / m 2 / nm) and the OPN5 absorption spectrum at each wavelength to form the benchmark effective spectral irradiance (W / m 2 / nm, and the benchmark effective spectral irradiance (W / m 2 / nm) and effective spectral irradiance (W / m 2 / nm) for comparison.

[0124] Specifically, for example, the spectral irradiance (W / m 2 The benchmark effective spectral irradiance (W / m2 / nm). In addition, in the spectrum of light received by the irradiated object, the effective spectral irradiance (W / m 2 / nm), calculated as the product of the spectral irradiance of the light at each wavelength in the wavelength region of 280nm to 500nm and the relative absorbance of the OPN5 absorption spectrum data at each wavelength. In the comparison between the calculated reference effective spectral irradiance and the calculated light-receiving effective spectral irradiance, the light-receiving effective spectral irradiance can be adjusted to a range of more than 0.2% of the reference effective spectral irradiance. This range can be referred to as a range in which the irradiation conditions of light can be adjusted to irradiate realistic light to the irradiated object. In addition, if the lower limit of the range is less than 0.2%, the irradiation of light is very small and sometimes does not produce a sufficient effect. On the other hand, the upper limit of the range can be set to 4000%.

[0125] The above range is based on the reference effective spectral irradiance formed by the product of the spectral irradiance of the sunlight spectrum specified by AM1.5G and the OPN5 absorption spectrum at each wavelength. The reference effective spectral irradiance is set to [received effective spectral irradiance] / [reference effective spectral irradiance]×100 for comparison, wherein the received effective spectral irradiance is calculated as the product of the spectral irradiance of the spectrum of the actually received light (spectral irradiance at each wavelength in the wavelength range of 280nm to 500nm) and the relative absorbance of the OPN5 absorption spectrum data at each wavelength. Through this comparison, the degree (ratio: %) of the actual received effective spectral irradiance relative to the common reference effective spectral irradiance can be generally evaluated regardless of the measurement area and measurement time. The objective relationship between the effect on the body obtained by OPN5 can be clarified based on the calculated result.

[0126] Fig.12 Yes Fig.11 The reference effective spectral irradiance (reference symbol b) shown in (C) is Fig. 9 The graph is obtained by comparing the effective spectral irradiance (reference numeral a) shown in (C) of the light received. Fig. 9 The effective spectral irradiance obtained from the received light is the reference effective spectral irradiance (W / m2) formed by multiplying the spectral irradiance of the sunlight spectrum specified by AM1.5G at each wavelength by the OPN5 absorption spectrum at each wavelength. 2 / nm) for comparison. In this way, the degree (ratio: %) of the actual light-receiving effective spectral irradiance relative to the common reference effective spectral irradiance can be generally evaluated regardless of the measurement area and measurement time. Fig.12In the results shown, for example, the effective irradiance obtained by integrating in the wavelength range of 280 nm to 500 nm is 57 W / m 2 , in the case of purple light (reference symbol a), it is 3.3 W / m 2 , if the sunlight is set as 100% for benchmarking, the purple light can be evaluated as 6%. In this way, by comparing with the value obtained by benchmarking with the sunlight as 100%, the objective relationship between the comparison result and the effect on the body obtained by OPN5 can be clearly understood. In addition, the obtained effective irradiance of light can be compared not only with the benchmark effective irradiance of sunlight, but also with the effective irradiance of light obtained by other light source systems, so that comparison between light sources can be made.

[0127] In addition, "AM1.5G" refers to sunlight data adopted at a standard level in solar cell development, etc., and "AM" refers to Air Mass. This AM1.5G is data standardized by ASTM (American Society for Testing and Materials) as shown in the URL "https: / / unit.aist.go.jp / rp-envene2022 / PV / ja / about_pv / output / measure.html", and the data is made public at "https: / / tinystones.net / pv / pv04.html" (National Renewable Energy Laboratory (NREL) of the United States) ("https: / / www.nrel.gov / grid / solar-resource / spectra.html").

[0128] according to Fig.11 From (c), we can see that the maximum effective spectral irradiance is 0.93W / m 2 / nm (value at 402nm). As mentioned above, the integral value of effective irradiance in the wavelength region of 280nm to 500nm is 57W / m 2 It can be seen that the effective dose of 3 hours of AM1.5G sunlight a day is 57W / m 2 Multiplying the value by 10800 seconds gives 615,600 J / m 2 (=615.6kJ / m 2 ). In addition, regarding the maximum value, if the maximum value of the effective spectral irradiance is set to about 1W / m 2 / nm, it can be 10 times as strong as 10W / m 2 If the effective spectral irradiance is a rectangular spectrum, the effective irradiance is 10W / m2 / nm×220nm=2200W / m 2 , it can be assumed that the effective irradiance is irradiated for 3 hours a day, and the effective dose is 21,600,000 J / m 2 (=21.6MJ / m 2 ).

[0129] As mentioned above, the effective irradiance obtained by integrating in the wavelength range of 280nm to 500nm is 57W / m 2 , 3.3W / m in the case of purple light 2 Regarding this value, for example, as a minimum value, the effective spectral irradiance can be set to 0.01 W / m 2 / nm, the effective irradiance is set to 0.1W / m 2 , the effective dose is set to 1000 J / m 2 In addition, as the highest value, the effective spectral irradiance can be set to 10W / m 2 / nm, effective irradiance is set to 2200W / m 2 , the effective dose is set at 21.6MJ / m 2 (M is an example of million.) In addition, the effective irradiance is a value when irradiation is performed for 3 hours.

[0130] The optical spectrum data can be compared and calculated in the whole or a part of the wavelength region of the OPN5 absorption spectrum. In this way, even if the received light contains various optical spectrum data, it can be compared and calculated in the whole or a part of the wavelength region of the OPN5 absorption spectrum. Therefore, it can be applied to any evaluation that uses a filter or the like to determine the wavelength region of the light. As a result, it can be used as a measuring device for clarifying whether the effect on the body obtained by OPN5 is related to the effective spectral irradiance of the light received in the entire wavelength region of the OPN5 absorption spectrum or the effective spectral irradiance of the light received in a specific wavelength region of the OPN5 absorption spectrum. In addition, as the determination of the wavelength region of the light using a filter or the like, for example, a specific wavelength region such as the wavelength region of 360nm to 400nm of ultraviolet light can also be determined.

[0131] In the above example, the spectral irradiance of the spectrum of the actually received light is set to the spectral irradiance at each wavelength in the wavelength range of 280nm to 500nm, but the wavelength range may also be set to a specific range. For example, in the calculation unit, when making a comparison within a wavelength range, the effective spectral irradiance of the received light may be integrated within the wavelength range to obtain (W / m 2), and integrate the effective irradiance of the light received in the same wavelength region and the reference effective spectral irradiance. The results can also be compared for evaluation.

[0132] For comparison of the integration results, for example, the effective irradiance (W / m 2 ) The benchmark effective irradiance of sunlight is compared with the effective irradiance of ultraviolet light, and the effective irradiance of ultraviolet light is compared with the benchmark effective irradiance of sunlight.

[0133] In the calculation unit, the effective irradiance (W / m 2 ) multiplied by the irradiation time (seconds) to obtain the effective dose (J / m 2 ) and the reference effective irradiance (W / m 2 ) multiplied by the irradiation time (seconds) to obtain the reference effective dose (J / m 2 ) is compared (for example, ratio: %) to evaluate the irradiation time dependence of the effect of light on the body through absorption of light by the body via OPN5. In addition, the dose is the amount of light irradiated in a day, and the irradiation time may be short (for example, a case of briefly irradiating strong flash-like light) or long-term irradiation of weak light. On the other hand, the time (time period) of irradiation is not particularly limited, but in fact, irradiation during the day is more effective.

[0134] Through such evaluation based on effective irradiance and effective dose, it is possible to quantitatively evaluate the effect on the body caused by the body absorbing light through OPN 5. By clarifying this relationship, it is possible to evaluate, for example, whether light of a certain wavelength range, irradiated at a certain irradiance, in a certain time period, and for a certain period of time is effective based on the relationship with the effect of OPN 5 on the body.

[0135] The measuring unit can be exemplified by Figure 8 The sensor 12 shown in (A) and (B) is preferably provided on glasses, headphones, watches, badges or other articles worn on the body, worn on the body itself by pasting, etc., or installed on an object near or around the body. The installation in this manner is arbitrarily selected and set based on the setting method of the light source for irradiating light (light source method, setting position of the light source, etc.), so it is not easy to become an obstacle in daily life, and it is easy to measure the light spectrum data received by the eyes and the body.

[0136] (Measurement of spectral data)

[0137] The spectral data of light can usually be measured by a spectrometer (spectrometer) or a UV meter (also called a power meter). The spectrometer can measure and obtain the spectral irradiance, and if the result is integrated with respect to the wavelength, it is the irradiance. If the integration is performed in a wavelength region within a specific range, it can be expressed as the irradiance within the wavelength region, so it can be preferably used. On the other hand, the UV meter can directly display the irradiance. For example, the commercially available UVA meter senses light of 320nm to 400nm and displays the irradiance within the wavelength region, so it is convenient, but from a quantitative point of view, it is preferably calibrated according to the sensor used. Therefore, since the UV meter cannot measure the spectral information (wavelength dependence), it can be said that it is difficult to apply to the various spectral quantities in the present invention. In addition, the "dose" is simply obtained by multiplying the irradiance by the irradiation time (seconds).

[0138] [Light irradiation system]

[0139] Regarding the light irradiation system, the first to third aspects of (1) to (3) mentioned above can be cited.

[0140] (First light irradiation system)

[0141] The first light irradiation system involved in the present invention is characterized in that it has one or more light sources, and the one or more light sources irradiate light of a wavelength region overlapping with the peak wavelength of the opsin 5 absorption spectrum, that is, the OPN5 absorption spectrum, and the light irradiation system adjusts one or more selected from the setting position of the light source, the irradiation direction of the light, the wavelength range of the light, the irradiance of the light, the irradiation time period of the light, and the irradiation time of the light. According to the first light irradiation system, the light source can be adjusted according to any of the above, so that the irradiated body is irradiated with light of a wavelength region overlapping with the peak wavelength of the OPN5 absorption spectrum. As a result, it is advantageous for activating OPN5 present in the retina of a person as the irradiated body.

[0142] The second light irradiation system involved in the present invention is characterized in that it has one or more light sources, and the one or more light sources irradiate light with a wavelength in a wavelength region overlapping with the peak wavelength of the absorption spectrum of opsin 5, that is, OPN5. In the spectrum of the light received by the irradiated body, the unit is W / m 2 The effective spectral irradiance of the light received by the sensor is adjusted to W / m 2 / nm, wherein the effective spectral irradiance of the received light is calculated as W / m at each wavelength in the wavelength range of 280nm to 500nm of the light. 2The reference effective spectral irradiance is calculated as the product of the spectral irradiance of 100 nm / nm and the relative absorbance of the OPN5 absorption spectrum data at each wavelength. The unit of the reference effective spectral irradiance is W / m 2 The product of the spectral irradiance of / nm and the relative absorbance of the OPN5 absorption spectrum at each wavelength. According to the second light irradiation system, the spectrum of light received by the irradiated body is adjusted so that the effective spectral irradiance of the received light is more than 0.2% of the reference effective spectral irradiance. As a result, it is beneficial for the activation of OPN5 present in the retina of a person as the irradiated body. The light that becomes the proportion within the above range is calculated based on the spectrum of light measured at the irradiated body or at a position around the irradiated body.

[0143] (Third light irradiation system)

[0144] The third light irradiation system according to the present invention is characterized in that it is composed of a light irradiation unit and a light measurement unit, the light irradiation unit having one or more light sources, the one or more light sources irradiating light of a wavelength region overlapping with a peak wavelength of an absorption spectrum of opsin 5, namely, OPN5, the light measurement unit measuring spectrum data of the light and comparing the spectrum data of the light with the OPN5 absorption spectrum data, and the light irradiation system adjusting one or more selected from the setting position of the light source, the irradiation direction of the light, the wavelength range of the light, the irradiance of the light, the irradiation time period of the light, and the irradiation time of the light based on the result of the comparison. According to the third light irradiation system, the setting position of the light source, the irradiation direction of the light, the wavelength range of the light, the irradiance, the irradiation time period, or the irradiation time is adjusted based on the result of the comparison in the light measurement method. As a result, it is advantageous for the activation of OPN5 present in the retina of a person as an irradiated body.

[0145] Since the components of the first to third light irradiation systems have been described above, their description will be omitted below, and components that have not been described above will be described below.

[0146] (Light Sensor)

[0147] In the light irradiation system, the effective spectral irradiance of the light actually received by the eye is determined, and thus the actual spectral irradiance of the light received by the eye is measured by using a light sensor. As a light sensor, for example, a GaAsP photodiode can be listed, and any of them can be selected and applied. For example Figure 8As shown, this optical sensor 12 can be an optical sensor 12 set on glasses, a sensor 12 in the form of a badge, or an optical sensor set around the eyes, without any special limitation. There is no special limitation on the scheme of setting the optical sensor on glasses and the scheme of setting the optical sensor around the eyes. It can also be directly fixed to the glasses, or hung on the glasses by a hook or the like. In addition, the optical sensor can also be fixed to an ear hanging clamp or the like to hang on the ear. As described in the description column of the measurement of spectral data, the optical sensor preferably includes a spectrometer (spectrometer).

[0148] (Light source setting and light adjustment)

[0149] In the light irradiation system, the arrangement of the light source (including the arrangement when a diffuser or reflector is provided as needed) and the adjustment of the light reaching the eye are important. The light reaching the eye can be adjusted by the arrangement of the light source and the adjustment of the light described below. As the method of adjusting the light, the adjustment scheme related to the irradiation conditions of the light and the adjustment scheme of the directivity of the light can be listed.

[0150] As an "adjustment scheme related to light irradiation conditions", it is preferred that the light emitted from one or more light sources is adjusted according to one or more schemes selected from setting or changing the wavelength range, setting or changing the irradiance, setting or changing the time period, and setting or changing the irradiation time.

[0151] Regarding “setting or changing the wavelength range”, “setting a specific wavelength range” refers to setting the wavelength range of light irradiated from a light source, and for example, a scheme of emitting light in a specific wavelength range by setting a light source that emits light in a specific wavelength range, or setting a filter that transmits a specific wavelength range on the front surface of the light source to emit light in a specific wavelength range. In addition, “changing a specific wavelength range” refers to changing the wavelength range of light irradiated from a light source, and for example, a scheme of changing by switching to another light source that emits light in a different wavelength range, or switching to another filter that transmits a specific wavelength range on the front surface of the light source to transmit light in a different wavelength range can be listed.

[0152] "Setting or changing the irradiance" means setting or changing the irradiance of the light emitted from the light source to an arbitrary value. Such setting or changing of the irradiance is preferably set or changed according to the degree of irradiance of the effective spectrum of light received by the eye. In the case where a sufficient irradiance of the effective spectrum of light received is received from the perspective of the light effect of OPN5 evaluated based on the light measurement unit of the present invention, the irradiation can be stopped or the irradiance can be reduced. On the other hand, in the case where an insufficient irradiance of the effective spectrum of light received is received from the perspective of the light effect of OPN5 evaluated based on the light measurement unit of the present invention, the irradiance can be increased. Specifically, for example, in the case of using a violet light source that emits violet light with a wavelength of 360nm to 400nm, the lower limit of the irradiance can preferably be set to 0.05W / m 2 (5μW / cm 2 ), more preferably 0.10 W / m 2 , and more preferably 0.2 W / m 2 The upper limit of the irradiance can preferably be set to 2000 W / m 2 , more preferably 20W / m 2 , and more preferably 10W / m 2 The actual irradiance range can be set to a range obtained by combining the above lower limit value and upper limit value, and it is preferable to arbitrarily set or change the irradiance within such a range.

[0153] "Setting or changing the time period" means arbitrarily setting or changing the time period in which light is radiated from the light source. Regarding the setting or changing of the time period, it is preferred to set or change it based on which time period the light should be irradiated from the viewpoint of the light effect of OPN5 evaluated based on the light measurement unit of the present invention. Specifically, for example, after the evening when the sun has set, light within the range of the absorption spectrum of OPN5 cannot be obtained from the sun outdoors. Therefore, from the viewpoint of not disrupting the circadian rhythm, it is desirable not to set or change the time period in which the light is irradiated indoors after the evening when the sun has set. In addition, since the time period can be set arbitrarily, it can also be a period of time that is regular or intermittent.

[0154] "Setting or changing the irradiation time" means arbitrarily setting or changing the irradiation time of light radiated from a light source. Regarding the setting or changing of the irradiation time, it is preferred to set or change it based on the length of time for which the light should be irradiated based on the comparison results of the light measurement unit based on the present invention. Specifically, for example, the irradiation may be performed intermittently or discontinuously. In addition, when setting or changing the irradiation time, it is preferred to also set the irradiance.

[0155] As a "scheme for adjusting the directivity of light", for example, it is preferred that the light emitted from one or more light sources be directed toward the eye by one or more schemes selected from the following: setting or changing the light source (including setting or changing the light source when a diffuser or reflector is provided as needed), setting or changing the angle of light emitted from the light source, setting or changing the diffusion angle of the diffuser when a diffuser for diffusing light is provided and the light source using the diffuser, adjusting the reflection angle of the reflector when a reflector for reflecting light is provided and setting or changing the light source using the reflector. This method is a scheme for adjusting the directivity of light. From the perspective of the light effect of OPN5, "directivity" is an important factor. For example, in the case of desk work, it is particularly desirable to set the light source in front of the line of sight so that it irradiates in the direction of the eyes. In addition, if Figure 7 As shown, it is preferable that the direction of light can be changed from "D" to "D'" automatically or manually.

[0156] As described, "setting or changing the light source", "setting or changing the angle of light emitted from the light source", "setting or changing the diffuse material for diffusing light", and "setting or changing the reflective material for reflecting light" all preferably set the direction of light in advance to the direction of the eyes, or set it to be changeable to any direction.

[0157] (use)

[0158] The first to third light irradiation systems of the present invention are advantageous for activating OPN5 present in the retina of a person being irradiated. By implementing such a light irradiation system, visual function and non-visual function can be improved, myopia progression can be inhibited (for example, the elongation of the axial length can be inhibited), the occurrence of myopia can be inhibited, the thickness of the choroid, cerebral blood flow, the effects on the nervous system and the effects on other things (testis, skin, etc.) can be improved, and the exploration and development of these studies can be expected.

[0159] Description of Reference Numerals

[0160] 10: light source; 11: reflective material; 12: sensor; D, D': direction of light; 21: light measuring unit; 22: measuring unit; 23: computing unit; 24: memory; 25: output unit (display unit).

Claims

1. A light irradiation system, characterized in that: The device is provided with one or more light sources, wherein the one or more light sources irradiate light of a wavelength region overlapping with a peak wavelength of an absorption spectrum of visual protein 5, i.e., an absorption spectrum of OPN5, and the light irradiation system adjusts one or more selected from a setting position of the light source, an irradiation direction of the light, a wavelength range of the light, an irradiance of the light, an irradiation time period of the light, and an irradiation time of the light.

2. A light irradiation system, characterized in that: A device having one or more light sources, wherein the one or more light sources irradiate light having a wavelength in a wavelength region overlapping with a peak wavelength of an absorption spectrum of opsin 5, i.e., an absorption spectrum of OPN5, wherein the unit of the light received by the irradiated object is W / m 2 The effective spectral irradiance of the light received by the sensor is adjusted to W / m 2 / nm, wherein the effective spectral irradiance of the received light is calculated as W / m at each wavelength in the wavelength range of 280nm to 500nm of the light. 2 The reference effective spectral irradiance is calculated as the product of the spectral irradiance of 100 nm / nm and the relative absorbance of the OPN5 absorption spectrum data at each wavelength. The unit of the reference effective spectral irradiance is W / m 2 The product of the spectral irradiance of / nm and the relative absorbance of the OPN5 absorption spectrum at each wavelength.

3. A light irradiation system, characterized in that: The light irradiation system is composed of a light irradiation unit and a light measuring unit, wherein the light irradiation unit has one or more light sources, and the one or more light sources irradiate light of a wavelength region overlapping with a peak wavelength of an absorption spectrum of opsin 5, i.e., an OPN5 absorption spectrum; the light measuring unit measures spectral data of the light and compares the spectral data of the light with the OPN5 absorption spectrum data; and the light irradiation system adjusts one or more selected from the setting position of the light source, the irradiation direction of the light, the wavelength range of the light, the irradiance of the light, the irradiation time period of the light, and the irradiation time of the light based on a result of the comparison.

4. The light irradiation system according to any one of claims 1 to 3, characterized in that: The light is light including 380 nm which is a peak wavelength of the absorption spectrum of the OPN5.

5. The light irradiation system according to claim 4, characterized in that: The light is light having a wavelength of 400 nm or less or 410 nm or less.

6. The light irradiation system according to any one of claims 1 to 3, characterized in that: The light source is configured at one or more positions selected from the following positions: a position where the light is irradiated toward an irradiated object as an irradiation object; a position where the light enters the field of view of the irradiated object; a position in the line of sight direction viewed from the side of the irradiated object; a position where the light is irradiated toward the irradiated object as diffused light after being diffused by a diffusing material; and a position where the light is irradiated toward the irradiated object as reflected light after being reflected by a reflecting material.

7. The light irradiation system according to claim 6, characterized in that: (i) when the light source is arranged at a position to irradiate the light toward an irradiated object, the irradiance of the light is adjusted by using the distance and / or angle from the light source to the irradiated object; (ii) when the light source is arranged at a position that enters the field of view of the illuminated object or at a position in the line of sight direction viewed from the illuminated object, the irradiance of the light is adjusted by using the distance and / or angle from the light source to the illuminated object; (iii) when the light source is arranged at a position where the light is irradiated to the irradiated object as diffused light diffused by the diffusing material, the irradiance of the light is adjusted by using the distance and / or angle from the light source and the diffusing material to the irradiated object, or the diffusion angle and / or transmittance of the diffusing material; (iv) When the light source is arranged at a position where the reflected light after being reflected by the reflecting material irradiates the irradiated object, the irradiance of the light is adjusted by utilizing the distance and / or angle from the light source and the reflecting material to the irradiated object, or the reflection angle and / or reflectivity of the reflecting material.

8. The light irradiation system according to any one of claims 1 to 3, characterized in that: The light source is selected from a structure-mounted light source, a setting-mounted light source, a built-in or mounted light source, a body-mounted tool-mounted light source, and a functional device-mounted light source. The structure-mounted light source is mounted on the ground, wall, ceiling, or other structures, wherein the ground also includes the ground under the feet, and the ceiling also includes hanging objects. The setting-mounted light source is mounted on a desk, a dining table, a partition, a shelf, a table component, a personal computer, a display, a PC keyboard, a television, an audio system, or other equipment or settings, wherein the partition is a partition wall or a screen. The built-in or mounted light source is a built-in or mounted light source of a portable personal computer, a tablet computer, a smart phone, or other portable terminals. The body-mounted tool-mounted light source is mounted on or detachably mounted as an accessory to a vision correction tool, an eye protection tool, a face protection tool, a neck hanging tool, an ear hanging tool, a head-mounted tool, or other body-mounted tools. The functional device-mounted light source is mounted on a functional device for AR, VR, or MR, wherein the functional device is a pair of goggles, headphones, or other functional devices.

9. The light irradiation system according to any one of claims 1 to 3, characterized in that: The direction or position of the light source is adjusted manually or automatically.

10. The light irradiation system according to claim 3, characterized in that: The unit of light is W / m 2 The unit is W / m 2 / nm effective spectral irradiance of light received.

11. The light irradiation system according to claim 10, characterized in that: The unit of calculation is W / m 2 The unit is W / m 2 / nm, and the unit is W / m 2 / nm benchmark effective spectral irradiance and the unit is W / m 2 / nm is used for comparison of the effective spectral irradiance of the light received.

12. The light irradiation system according to claim 3, characterized in that: The spectrum data of the light is calculated by comparing the whole or part of the wavelength region of the absorption spectrum of the OPN5.

13. The light irradiation system according to claim 12, characterized in that: When comparing within the wavelength region, the unit W / m 2 / nm is obtained by integrating the effective spectral irradiance of the light received to obtain the unit of W / m 2 The effective irradiance of the light received is W / m 2 / nm is integrated to obtain the unit of W / m 2 The obtained effective irradiance of the received light is compared with the reference effective irradiance.

14. The light irradiation system according to claim 13, characterized in that: The unit is W / m 2 The unit is J / m, which is obtained by multiplying the effective irradiance of the light by the exposure time in seconds. 2 The effective dose of light is W / m 2 The unit is J / m 2 The reference effective dose of light is used for comparison.

15. The light irradiation system according to claim 3, characterized in that: The measurement is performed by a measuring unit, which is set on glasses, headphones, watches, badges or other items worn on the body, or is worn on the body itself, or is installed in a setting near or around the body based on the way the light source irradiates the light.

16. A light irradiation method, characterized in that: The light is irradiated from one or more light sources that irradiate light of a wavelength region overlapping with a peak wavelength of an absorption spectrum of visual protein 5, i.e., OPN5, toward an irradiated object, and spectrum data of the light received by the irradiated light is compared with the OPN5 absorption spectrum data, and irradiation conditions of the light are adjusted based on a result of the comparison, wherein the irradiation conditions of the light are one or more conditions selected from a setting position of the light source, an irradiation direction of the light, a wavelength range of the light, an irradiance of the light, an irradiation time period of the light, and an irradiation time of the light.

17. The light irradiation method according to claim 16, characterized in that: The method further includes a light measurement scheme, in which the spectrum data of the light is measured and compared with the OPN5 absorption spectrum data. In the light irradiation method, the unit of the product of the spectrum data of the light and the OPN5 absorption spectrum data for each wavelength is calculated as W / m 2 / nm effective spectral irradiance of light received.

18. A method for optical measurement, characterized in that: Spectral data of light with a wavelength in a wavelength region overlapping with a peak wavelength of the visual protein 5 absorption spectrum, i.e., the OPN5 absorption spectrum, is measured, and the measured spectral data of the light is compared with the pre-stored OPN5 absorption spectrum data, and the comparison result is displayed on a display device or output as data.

19. The light measurement method according to claim 18, characterized in that: The comparison is performed by a calculation unit, in which the product of the spectrum data of the light and the absorption spectrum data of the OPN5 for each wavelength is calculated in units of W / m 2 / nm effective spectral irradiance of light received.

20. The optical measurement method according to claim 19, characterized in that: The unit of calculation is W / m 2 The unit is W / m 2 / nm, and the unit is W / m 2 / nm benchmark effective spectral irradiance and the unit is W / m 2 / nm is used for comparison of the effective spectral irradiance of the light received.

21. The optical measurement method according to claim 18 or 19, characterized in that: The spectral data of the light is compared over all or a portion of the wavelength region of the OPN5 absorption spectrum.

22. The optical measurement method according to claim 21, characterized in that: When comparing within the wavelength region, the effective spectral irradiance of the received light is integrated within the wavelength region to obtain the unit of W / m 2 The effective irradiance of the received light is calculated by integrating the reference effective spectral irradiance in the same wavelength region to obtain the value in W / m 2 The obtained effective irradiance of the received light is compared with the reference effective irradiance.

23. The optical measurement method according to claim 22, characterized in that: The unit is W / m 2 The unit is J / m, which is obtained by multiplying the effective irradiance of the light by the exposure time in seconds. 2 The effective dose of light is W / m 2 The unit is J / m 2 The reference effective dose of light is used for comparison.

24. The optical measurement method according to claim 18 or 19, characterized in that: The measurement is performed by a measuring unit, which is set on glasses, headphones, watches, badges or other items worn on the body, or is worn on the body itself, or is installed in a setting near or around the body based on the way the light source irradiates the light.

25. A light measuring device, characterized in that: A measuring unit is provided for measuring spectrum data of light having a wavelength in a wavelength region overlapping with a peak wavelength of an opsin 5 absorption spectrum, namely, an OPN5 absorption spectrum, The light measuring device compares the spectrum data of the light measured by the measuring unit with the absorption spectrum data of the OPN5 stored in advance, and displays the result of the comparison on a display device or outputs it as data.

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