Intragastric weight-losing water ball

Abstract

The invention relates to the technical field of weight-reducing instruments, and discloses an intragastric weight-reducing water ball which is made of a degradable material, and the degradable material comprises the following components in percentage by weight: 40-50% of polylactic acid, 30-40% of polyhydroxybutyrate, 15-25% of a natural cellulose material and 5-15% of a surface modifier. The intragastric weight-losing water ball is made of degradable materials such as polylactic acid and polyhydroxybutyrate, and the materials can be decomposed and absorbed in a human body and cannot cause potential health risks to the human body. And the natural cellulose material is added, so that the dissolving time of the weight-losing water balls in the stomach can be prolonged, the retention time of the weight-losing water balls in the stomach is longer, the appetite is further delayed, and the duration of satiety is prolonged. And polyethyleneimine and polyvinyl alcohol can improve the stability of the water balls and prevent the water balls from being dissolved or broken too early in the stomach. The food intake can be effectively reduced, and the duration of satiety can be prolonged.

Description

Technical Field

[0001] The invention relates to the technical field of weight loss equipment, in particular to an intragastric weight loss water ball. Background Art

[0002] Weight loss refers to a scientific method to achieve the goal of healthy weight loss. In recent years, many foreign experts and scholars have conducted extensive and in-depth research on weight loss methods and proposed many effective methods, which can be roughly divided into two categories: 1. Scientific diet weight loss method, which achieves the goal of weight loss by scientifically controlling daily diet; 2. Menstrual period weight loss method, which achieves the goal of weight loss based on the body's functional conditions and combined with diet.

[0003] Losing weight is not a short-term fast diet or high-intensity exercise that can be successful. The reason for gaining weight is that there is something wrong with your lifestyle, either eating too much or exercising too little.

[0004] There are some existing technologies that place balloons in the stomach to occupy the space in the stomach, thereby achieving dieting, increasing satiety, and reasonably controlling the amount of food, and ultimately achieving the purpose of controlling and improving weight. However, traditional weight loss water balloons are usually made of non-degradable materials, and they require surgery or the help of endoscopy to put in and take out of the stomach. This makes the operation process relatively complicated and may be accompanied by certain risks and discomfort. Secondly, since the water balloons are non-degradable, once placed in the stomach, they will exist permanently, which may cause long-term discomfort or complications. Summary of the invention

[0005] In view of the deficiencies in the prior art, the present invention provides an intragastric weight-loss water ball, which solves the problem that the traditional weight-loss water ball is non-degradable.

[0006] To achieve the above objectives, the present invention is implemented through the following technical scheme: an intragastric weight loss water ball, the weight loss water ball is made of a degradable material, and the degradable material includes the following components by weight percentage: 40-50% polylactic acid, 30-40% polyhydroxybutyrate, 15-25% natural cellulose material and 5-15% surface modifier.

[0007] Preferably, the natural cellulose material is selected from one of wood cellulose, algae cellulose and cellulose nanocrystals.

[0008] Preferably, the surface modifier is selected from one of polyethyleneimine and polyvinyl alcohol.

[0009] Preferably, the outer wall of the weight-loss water ball is provided with a soluble coating layer.

[0010] Preferably, the soluble coating layer comprises the following components by weight percentage: 30-40% polylactic acid, 20-30% polyhydroxybutyrate, 20-25% sodium carboxymethyl cellulose, 5-10% polyethyleneimine and 5-10% polyvinyl alcohol.

[0011] Preferably, the soluble coating layer is provided on the outer wall of the weight-loss water ball by coating or dipping.

[0012] The present invention provides a method for preparing an intragastric weight-loss water ball, comprising the following steps: S1. Add the polylactic acid and polyhydroxybutyrate in the weight loss water ball formula into the reactor according to the specified ratio, and stir and mix at a temperature of 70-80° C. and a stirring speed of 100-200 rpm for 30-50 minutes; S2, adding the natural cellulose material to the mixture, and continuing to stir and mix for 30-60 minutes; S3, gradually adding the surface modifier to the mixture, and continuing to stir and mix for 15-30 minutes; S4. The mixture is injection molded by an injection molding machine, and heat treated at a temperature of 50-100° C. to obtain a water ball body.

[0013] Preferably, the preparation of the soluble coating layer comprises the following steps: S10, adding polylactic acid and polyhydroxybutyrate in the soluble coating layer formula into 60-70° C. water according to the proportion, stirring and dissolving at a stirring speed of 500-700 rpm for 1-2 hours; S20, adding sodium carboxymethyl cellulose to the mixed solution, and stirring at a stirring speed of 600-800 rpm for 30-40 min; S30, adding polyethyleneimine and polyvinyl alcohol to the mixed solution, stirring and mixing at a stirring speed of 800-1200 rpm for 10-20 min to obtain a soluble coating layer solution; S40, applying the obtained soluble coating layer liquid on the outer wall of the weight loss water ball by coating or dipping, and after solidification, the weight loss water ball with a soluble coating layer is obtained.

[0014] The present invention provides an intragastric weight loss water ball, which has the following beneficial effects: The intragastric slimming water ball of the present invention is made of degradable materials, such as polylactic acid, polyhydroxybutyrate, etc. These materials can be decomposed and absorbed in the human body and will not cause potential health risks to the human body. The addition of natural cellulose materials can prolong the dissolution time of the intragastric slimming water ball, so that it stays in the stomach for a longer time, further delays the generation of appetite, and increases the duration of satiety. Polyethyleneimine and polyvinyl alcohol can improve the stability of the water ball and prevent it from dissolving or rupturing prematurely in the stomach. It can effectively reduce the amount of food intake and prolong the duration of satiety. DETAILED DESCRIPTION

[0015] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0016] The intragastric slimming water ball is a device for slimming, which can expand in the stomach to form a certain volume, thereby reducing the amount of food intake and achieving the effect of slimming. The invention provides an intragastric slimming water ball and a preparation method thereof.

[0017] The intragastric slimming water ball is made of degradable materials, which can avoid the residue of non-degradable substances in the human body and improve safety. Among them, the formula of the degradable material includes polylactic acid, polyhydroxybutyrate, natural cellulose material and surface modifier.

[0018] Degradable materials, by weight percentage, include: 40-50% polylactic acid, which has good degradability and biocompatibility.

[0019] 30-40% polyhydroxybutyrate, which also has good degradability and biocompatibility.

[0020] 15-25% natural cellulose material, which is a key component to increase the stability of the slimming water ball and prolong the dissolution time. One of wood cellulose, algae cellulose and cellulose nanocrystals can be selected as the natural cellulose material and added to the mixture for stirring and mixing to ensure uniform dispersion.

[0021] 5-15% surface modifier. The addition of surface modifier can improve the stability and lubricity of the slimming water ball and reduce the friction with the gastric mucosa. Polyethyleneimine and polyvinyl alcohol are commonly used surface modifiers. You can choose one or a mixture of the two. Add the surface modifier gradually to the mixture and continue to stir and mix to ensure uniform dispersion.

[0022] The present invention provides a method for preparing the intragastric weight-loss water balloon, comprising the following steps: S1. Add the polylactic acid and polyhydroxybutyrate in the weight loss water ball formula into the reactor according to the specified ratio, and stir and mix at a temperature of 70-80° C. and a stirring speed of 100-200 rpm for 30-50 minutes; S2, adding the natural cellulose material to the mixture, and continuing to stir and mix for 30-60 minutes; S3, gradually adding the surface modifier to the mixture, and continuing to stir and mix for 15-30 minutes; S4. The mixture is injection molded by an injection molding machine, and heat treated at a temperature of 50-100° C. to obtain a water ball body.

[0023] The intragastric slimming water ball of the present invention is made of degradable materials, such as polylactic acid, polyhydroxybutyrate, etc. These materials can be decomposed and absorbed in the human body and will not cause potential health risks to the human body. The addition of natural cellulose materials can prolong the dissolution time of the intragastric slimming water ball, so that it stays in the stomach for a longer time, further delays the generation of appetite, and increases the duration of satiety. Polyethyleneimine and polyvinyl alcohol can improve the stability of the water ball and prevent it from dissolving or rupturing prematurely in the stomach. It can effectively reduce the amount of food intake and prolong the duration of satiety.

[0024] As an embodiment of the present invention, the outer wall of the weight-loss water ball is provided with a soluble coating layer, and such a soluble coating layer can increase the stability of the water ball and prolong the dissolution time.

[0025] Specifically, the soluble coating layer includes the following components by weight percentage: 30-40% polylactic acid, 20-30% polyhydroxybutyrate, 20-25% sodium carboxymethyl cellulose, 5-10% polyethyleneimine and 5-10% polyvinyl alcohol.

[0026] As an embodiment of the present invention, the soluble coating layer is disposed on the outer wall of the weight-loss water ball by coating or dipping.

[0027] The present invention provides a method for preparing a soluble coating layer, comprising the following steps: S10, adding polylactic acid and polyhydroxybutyrate in the soluble coating layer formula into 60-70° C. water according to the proportion, stirring and dissolving at a stirring speed of 500-700 rpm for 1-2 hours; S20, adding sodium carboxymethyl cellulose to the mixed solution, and stirring at a stirring speed of 600-800 rpm for 30-40 min; S30, adding polyethyleneimine and polyvinyl alcohol to the mixed solution, stirring and mixing at a stirring speed of 800-1200 rpm for 10-20 min to obtain a soluble coating layer solution; S40, applying the obtained soluble coating layer liquid on the outer wall of the weight loss water ball by coating or dipping, and after solidification, the weight loss water ball with a soluble coating layer is obtained. Example

[0028] S1. Add 40% polylactic acid and 30% polyhydroxybutyrate into a reactor according to the prescribed ratio, and stir and mix at a temperature of 70°C and a stirring speed of 150 rpm for 40 minutes; S2, adding 20% ​​lignocellulose to the mixture, and continuing to stir and mix for 50 minutes; S3, gradually adding 10% polyethyleneimine and 10% polyvinyl alcohol into the mixture, and continuing to stir and mix for 20 minutes; S4, injection molding the mixture through an injection molding machine, and heat treating it at a temperature of 80° C. to obtain a water ball body; S10, adding 30% polylactic acid and 25% polyhydroxybutyrate into 60°C water according to the proportion, stirring and dissolving at a stirring speed of 600 rpm for 2 h; S20, adding 20% ​​sodium carboxymethyl cellulose to the mixed solution, and stirring at a stirring speed of 700 rpm for 40 min; S30, adding 5% polyethyleneimine and 5% polyvinyl alcohol to the mixed solution, stirring and mixing at a stirring speed of 1000 rpm for 15 minutes to obtain a soluble coating layer solution; S40, applying the obtained soluble coating layer liquid on the outer wall of the weight loss water ball by a coating method, and after solidification, a weight loss water ball with a soluble coating layer is obtained. Example

[0029] S1. Add 50% polylactic acid and 40% polyhydroxybutyrate into a reactor according to the prescribed ratio, and stir and mix at a temperature of 80°C and a stirring speed of 200 rpm for 50 minutes; S2, adding 15% algae cellulose to the mixture, and continuing to stir and mix for 60 minutes; S3, gradually add 5% polyethyleneimine and 10% polyvinyl alcohol into the mixture, and continue to stir and mix for 30 minutes; S4, injection molding the mixture through an injection molding machine, and heat treating it at a temperature of 70° C. to obtain a water ball body; S10, adding 40% polylactic acid and 30% polyhydroxybutyrate into 70°C water according to the proportion, stirring and dissolving at a stirring speed of 700 rpm for 1 hour; S20, adding 25% sodium carboxymethyl cellulose to the mixed solution, and stirring at a stirring speed of 800 rpm for 30 min; S30, adding 10% polyethyleneimine and 5% polyvinyl alcohol to the mixed solution, stirring and mixing at a stirring speed of 1200 rpm for 20 minutes to obtain a soluble coating layer solution; S40, setting the obtained soluble coating layer liquid on the outer wall of the weight loss water ball by using an immersion method, and obtaining the weight loss water ball with a soluble coating layer after solidification. Example

[0030] S1. Add 45% polylactic acid and 35% polyhydroxybutyrate into a reactor according to the prescribed ratio, and stir and mix at a temperature of 75°C and a stirring speed of 180 rpm for 45 minutes; S2, adding 20% ​​cellulose nanocrystals into the mixture, and continuing to stir and mix for 40 minutes; S3, gradually adding 15% polyethyleneimine and 10% polyvinyl alcohol into the mixture, and continuing to stir and mix for 25 minutes; S4, injection molding the mixture through an injection molding machine, and heat treating it at a temperature of 60° C. to obtain a water ball body; S10, adding 35% polylactic acid and 25% polyhydroxybutyrate into 65°C water according to the proportion, stirring and dissolving at a stirring speed of 650 rpm for 1.5 h; S20, adding 20% ​​sodium carboxymethyl cellulose to the mixed solution, and stirring at a stirring speed of 750 rpm for 35 min; S30, adding 5% polyethyleneimine and 5% polyvinyl alcohol to the mixed solution, stirring and mixing at a stirring speed of 900 rpm for 15 minutes to obtain a soluble coating layer solution; S40, applying the obtained soluble coating layer liquid on the outer wall of the weight loss water ball by a coating method, and after solidification, a weight loss water ball with a soluble coating layer is obtained. Example

[0031] S1. Add 50% polylactic acid and 30% polyhydroxybutyrate into a reactor according to the prescribed ratio, and stir and mix at a temperature of 75°C and a stirring speed of 150 rpm for 30 minutes; S2, adding 25% algae cellulose to the mixture, and continuing to stir and mix for 50 minutes; S3, gradually adding 10% polyethyleneimine and 5% polyvinyl alcohol into the mixture, and continuing to stir and mix for 20 minutes; S4, injection molding the mixture through an injection molding machine, and heat treating it at a temperature of 65° C. to obtain a water ball body; S10, adding 30% polylactic acid and 20% polyhydroxybutyrate into 68°C water according to the proportion, stirring and dissolving at a stirring speed of 650 rpm for 1.5 h; S20, adding 30% sodium carboxymethyl cellulose to the mixed solution, and stirring at a stirring speed of 700 rpm for 40 min; S30, adding 5% polyethyleneimine and 5% polyvinyl alcohol to the mixed solution, stirring and mixing at a stirring speed of 1000 rpm for 15 minutes to obtain a soluble coating layer solution; S40, applying the obtained soluble coating layer liquid on the outer wall of the weight loss water ball by a coating method, and after solidification, a weight loss water ball with a soluble coating layer is obtained. Example

[0032] S1. Add 45% polylactic acid and 35% polyhydroxybutyrate into a reactor according to the prescribed ratio, and stir and mix at a temperature of 80°C and a stirring speed of 200 rpm for 50 minutes; S2, adding 20% ​​cellulose nanocrystals into the mixture, and continuing to stir and mix for 40 minutes; S3, gradually adding 10% polyethyleneimine and 5% polyvinyl alcohol into the mixture, and continuing to stir and mix for 25 minutes; S4, injection molding the mixture through an injection molding machine, and heat treating it at a temperature of 70° C. to obtain a water ball body; S10, adding 35% polylactic acid and 25% polyhydroxybutyrate into 65°C water according to the proportion, stirring and dissolving at a stirring speed of 700 rpm for 2 h; S20, adding 20% ​​sodium carboxymethyl cellulose to the mixed solution, and stirring at a stirring speed of 800 rpm for 35 min; S30, adding 5% polyethyleneimine and 5% polyvinyl alcohol to the mixed solution, stirring and mixing at a stirring speed of 900 rpm for 15 minutes to obtain a soluble coating layer solution; S40, setting the obtained soluble coating layer liquid on the outer wall of the weight loss water ball by using an immersion method, and obtaining the weight loss water ball with a soluble coating layer after solidification.

[0033] Experimental example: Five water ball samples were prepared using the weight loss water ball preparation method in Examples 1-5 and subjected to a gastric environment stability test.

[0034] Experimental steps: 1. Place each water ball sample in simulated gastric fluid, which consists of 0.1M HCl solution.

[0035] 2. Stir the simulated gastric fluid in a thermostatic stirrer at 37°C at a speed of 100 rpm.

[0036] 3. Regularly observe the changes in the appearance of the water ball samples, record the time point when the water ball breaks or dissolves, and measure its volume loss rate when it breaks.

[0037] 4. Continue to observe until all water ball samples are broken or dissolved.

[0038] The experimental data table is as follows: serial number Rupture / dissolution time (months) Volume loss rate (%) Example 1 3.2 10.2 Example 2 3.8 8.7 Example 3 3.3 11.5 Example 4 2.9 15.3 Example 5 4.1 9.8 According to the above table, the following conclusions can be drawn: Rupture / dissolution time: The water balloon of Example 4 had the shortest rupture / dissolution time, which was 2.9 months. The water balloon of Example 5 had the longest rupture / dissolution time, which was 4.1 months. This indicates that the water balloon of the present invention has good stability in simulated gastric fluid and can prolong the rupture / dissolution time.

[0039] Volume loss rate: The water ball of Example 2 showed the lowest volume loss rate, which was 8.7%. The water ball of Example 4 showed the highest volume loss rate, which was 15.3%. This means that the water ball of the present invention can effectively reduce volume loss and maintain good stability.

[0040] In summary, according to the experimental results, the water ball of the present invention has good stability and low volume loss rate. Compared with other embodiments, the water ball of the present invention shows a longer rupture / dissolution time in simulated gastric fluid, which helps to slow down the drug release rate. In addition, the lower volume loss rate also shows that the water ball of the present invention can better maintain its original volume and shape. The material formula of the degradable part has good degradability and biocompatibility. They can be decomposed and absorbed in the human body and will not cause potential health risks to the human body.

[0041] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. An intragastric weight loss water ball, characterized in that: The weight-loss water ball is made of a degradable material, which comprises the following components by weight percentage: 40-50% of polylactic acid, 30-40% of polyhydroxybutyrate, 15-25% of natural cellulose material and 5-15% of a surface modifier.

2. The intragastric weight loss water ball according to claim 1, characterized in that: The natural cellulose material is selected from one of wood cellulose, algae cellulose and cellulose nanocrystals.

3. The intragastric weight loss water ball according to claim 1, characterized in that: The surface modifier is selected from one of polyethyleneimine and polyvinyl alcohol.

4. The intragastric weight loss water ball according to claim 1, characterized in that: The outer wall of the weight-loss water ball is provided with a soluble coating layer.

5. The intragastric weight loss water ball according to claim 4, characterized in that: The soluble coating layer comprises the following components by weight percentage: 30-40% of polylactic acid, 20-30% of polyhydroxybutyrate, 20-25% of sodium carboxymethyl cellulose, 5-10% of polyethyleneimine and 5-10% of polyvinyl alcohol.

6. The intragastric slimming water ball according to claim 5, characterized in that: The soluble coating layer is arranged on the outer wall of the weight-loss water ball by coating or dipping.

7. A method for preparing an intragastric slimming water ball, used for preparing an intragastric slimming water ball as claimed in any one of claims 1 to 6, characterized in that: The following steps are involved: S1. Add the polylactic acid and polyhydroxybutyrate in the weight loss water ball formula into the reactor according to the specified ratio, and stir and mix at a temperature of 70-80° C. and a stirring speed of 100-200 rpm for 30-50 minutes; S2, adding the natural cellulose material to the mixture, and continuing to stir and mix for 30-60 minutes; S3, gradually adding the surface modifier to the mixture, and continuing to stir and mix for 15-30 minutes; S4. The mixture is injection molded by an injection molding machine, and heat treated at a temperature of 50-100° C. to obtain a water ball body.

8. The method for preparing an intragastric weight loss water ball according to claim 7, characterized in that: The preparation of the soluble coating layer comprises the following steps: S10, adding polylactic acid and polyhydroxybutyrate in the soluble coating layer formula into 60-70° C. water according to the proportion, stirring and dissolving at a stirring speed of 500-700 rpm for 1-2 hours; S20, adding sodium carboxymethyl cellulose to the mixed solution, and stirring at a stirring speed of 600-800 rpm for 30-40 min; S30, adding polyethyleneimine and polyvinyl alcohol to the mixed solution, stirring and mixing at a stirring speed of 800-1200 rpm for 10-20 min to obtain a soluble coating layer solution; S40, applying the obtained soluble coating layer liquid on the outer wall of the weight loss water ball by coating or dipping, and after solidification, the weight loss water ball with a soluble coating layer is obtained.