Preparation method of zinc orotate

Abstract

The invention discloses a preparation method of zinc orotate, which comprises the following steps: S1, taking orotic acid and zinc oxide to fully react in water to generate zinc orotate, the reaction mode is high-temperature circular reaction, the reaction temperature is more than 90 DEG C, and the reaction time is 2-3 hours; the zinc oxide adopts nano zinc oxide; the molar ratio of the dosage of the orotic acid to the dosage of the zinc oxide is 1: (1.2-1.4); s2, solid-liquid separation: continuously stirring the separated liquid phase for 12-16 hours under the condition of 350r / s-550r / s, so that the zinc orotate is fully cooled, crystallized and separated out; and S3, carrying out solid-liquid separation on the reaction solution again, and drying the solid phase to obtain zinc orotate. By adopting the method provided by the invention, the zinc orotate product with high yield, high purity and good solubility can be prepared.

Description

Technical Field

[0001] The invention belongs to the technical field of food processing, and particularly relates to a preparation method of zinc orotate. Background Art

[0002] Orotic acid is also known as vitamin B13, but it can be synthesized by the human body and intestinal bacteria, so it is also classified as a vitamin. It is an organic acid belonging to the nucleic acid class of biochemicals and is a substance that can be naturally produced by the intestinal flora of organisms. It has a keto structure and an enol structure. As an important intermediate product for the synthesis of uracil nucleic acid and a precursor for the biosynthesis of DNA and RNA, it is a very important pyrimidine derivative. Orotic acid itself has a wide range of applications in the fields of medicine, food, daily chemicals and life sciences.

[0003] In recent years, a series of drugs based on orotic acid have been developed at home and abroad, such as nitroorotic acid, aminoorotic acid, aminopyrimidine orotate (Akamin), etc., which can treat a variety of liver diseases. Some derivatives of orotic acid also have significant therapeutic effects on heart disease. Orotic acid drugs have attracted much attention for their good efficacy, small side effects, no stimulation to the kidneys, low residual and accumulation in the body, etc. Orotic acid is not only a component of medical vitamins, but also widely used in cosmetics as a nutritional cosmetic matrix to promote cell metabolism and delay cell aging. Zinc is involved in the synthesis and activity of many enzymes in the body, such as carbonic anhydrase, DNA polymerase, RNA polymerase, etc., which can maintain the metabolism of the central nervous system and bone metabolism, promote the normal growth of children's physique (such as height, weight, head circumference, chest circumference, etc.), brain development, sexual characteristics development and sexual maturity, and has the effect of promoting growth and development and improving taste.

[0004] Combining orotic acid with zinc can not only bring out the advantages of orotic acid in the human body, that it has no stimulation to the kidneys and low accumulation of residual substances, but also has a high biological absorption and utilization rate. At the same time, it can treat the liver and heart, promote cell metabolism, delay aging, promote growth and development, and improve taste.

[0005] However, orotic acid itself is hydrophobic, poorly soluble in water (0.18%), 13% solubility in boiling water, slightly soluble in alcohol and organic solvents, insoluble in ether, and difficult to react thoroughly with other substances, resulting in a low yield of the corresponding orotate. Moreover, most orotates on the market exist in the form of orotate free acid or orotate chloride, and their solubility in pure water or organic solvents is very low.

[0006] Since orotic acid is poorly soluble in water and organic solvents, it is difficult to fully react with other substances, resulting in a low yield of the corresponding orotate. In addition, most orotate salts on the market have a relatively low solubility and are difficult to dissolve, resulting in a reduced absorption and utilization of the corresponding products. The solubility of zinc orotate is lower than that of other orotate salts such as magnesium orotate, so zinc orotate is less soluble.

[0007] Based on the above technical problems, the present application intends to provide a method for preparing zinc orotate, by which a readily soluble zinc orotate product can be obtained. Summary of the invention

[0008] The purpose of the present invention is to provide a method for preparing zinc orotate in order to solve the deficiencies of the prior art.

[0009] The purpose of the present invention is achieved by the following technical solutions:

[0010] A method for preparing zinc orotate comprises the following steps:

[0011] S1. Take orotic acid and zinc oxide and fully react them in water to generate zinc orotic acid. The reaction method is a high-temperature cycle reaction, the reaction temperature is above 90°C, and the reaction time is 2h to 3h; the zinc oxide is nano zinc oxide; the molar ratio of the orotic acid to the zinc oxide is 1:(1.2 to 1.4);

[0012] S2. Solid-liquid separation, taking the separated liquid phase and stirring it continuously at 350r / s to 550r / s for 12h to 16h to allow zinc orotate to be fully cooled and crystallized;

[0013] S3. The reaction solution is then separated into solid and liquid again, and the solid phase is dried to obtain zinc orotate.

[0014] Preferably, the reaction in step S1 is carried out in a circulation reactor.

[0015] Preferably, firstly, an orotic acid suspension and a zinc oxide suspension are prepared, and the orotic acid suspension is heated to above 90° C., and then the zinc oxide suspension is slowly added to the orotic acid suspension, and after mixing, the mixed solution is added to the circulation reactor for reaction.

[0016] Preferably, the zinc orotate suspension is prepared in the following steps:

[0017] Take orotic acid and add it into 1.5 to 2.5 times the mass of water, heat to 50°C to 70°C, and stir thoroughly.

[0018] Preferably, the zinc oxide suspension is prepared by:

[0019] Take zinc oxide and add it into 2 to 3 times the mass of water and stir thoroughly.

[0020] Preferably, the nano zinc oxide has an average particle size of 20 nm to 30 nm and is nearly spherical.

[0021] Preferably, step S2 uses circulating cooling water to cool to room temperature.

[0022] Preferably, the drying temperature in step S3 is 85° C. to 100° C., and the drying time is 16 h to 18 h.

[0023] Preferably, the solid-liquid separation method adopts a filtration method.

[0024] By adopting the method provided in the present application, a zinc orotate product with high yield, high purity and good solubility can be prepared. DETAILED DESCRIPTION

[0025] The present invention provides a method for preparing zinc orotate, comprising the following steps:

[0026] S1. Take orotic acid and zinc oxide and fully react them in water to generate zinc orotic acid. The reaction method is a high temperature cycle reaction, the reaction temperature is above 90°C, and the reaction time is 2h to 3h; the zinc oxide uses nano zinc oxide; the molar ratio of orotic acid to zinc oxide is 1:(1.2 to 1.4);

[0027] S2. Solid-liquid separation, taking the separated liquid phase and stirring it continuously at 350r / s~550r / for 12h~16h, so that the zinc orotate is fully cooled and crystallized; the solid-liquid separation method can be a separation method such as filtration and centrifugation; preferably, circulating cooling water is introduced outside the reactor to cool it to room temperature;

[0028] S3. The reaction solution is then separated into solid and liquid again, and the solid phase is dried to obtain the zinc orotate product.

[0029] The present application first adopts nano zinc oxide as raw material, and this nano zinc oxide has a nano-level near-spherical structure, has a smaller particle size, a larger specific surface area and a higher activity, can increase the contact area between the raw material of orotic acid, increase the reaction rate, and then through high temperature cycle reaction, improve the reaction heat effect, improve the reaction rate and the utilization rate of the raw material, make orotic acid and zinc oxide fully react, improve the yield of zinc orotic acid, and reduce the preparation cost of the product. Then adopt a constant speed cooling crystallization method, so that zinc orotic acid is precipitated in large quantities, and the particle morphology of the zinc orotic acid product is made more uniform and delicate, thereby further improving the product yield, so that the zinc orotic acid product can achieve an easily soluble effect.

[0030] Orotate and zinc oxide react to synthesize zinc orotate, and product can directly react to generate and can be directly separated out without being concentrated, so the application uses high temperature cycle reaction to improve its reaction degree, promotes zinc orotate product to fully generate and separate out;Similarly, due to zinc orotate can directly separate out, if using excessive orotate, orotate overreaction is incomplete, easily remains in the product, so as to reduce the content of zinc in the product (zinc content in the product is a key indicator). And using excessive zinc oxide, orotate can be urged to fully react, even if some unreacted zinc oxide remains in the product, the content of zinc in the product will not be reduced. Then adopt constant speed cooling crystallization method, make the particle form of the zinc orotate product separated out more uniform and smooth, improve the dissolution rate of the zinc orotate product.

[0031] In summary, the method provided in this application can be used to prepare a zinc orotate product with high yield, high purity and good solubility.

[0032] Preferably, the reaction in step S1 is carried out in a circulation reactor, in which the reaction temperature can be precisely controlled and the reaction system can be circulated to increase the contact effect between orotic acid and zinc oxide, thereby promoting a full reaction between the two.

[0033] Preferably, first prepare an orotic acid suspension and a zinc oxide suspension, heat the orotic acid suspension to above 90°C, then slowly add the zinc oxide suspension to the orotic acid suspension, and after mixing, add the mixed solution to a circulation reactor for reaction. Adding zinc oxide to orotic acid can facilitate observation of the degree of reaction, and as the reaction proceeds, insoluble orotic acid will gradually react with zinc oxide to clarify. Orotic acid suspension and zinc oxide suspension can also be directly added to a circulation reactor for reaction.

[0034] Further preferably, the preparation steps of zinc orotate suspension are:

[0035] Take orotic acid and add it to 1.5 to 2.5 times the mass of water, heat it to 50 to 70 degrees Celsius, and stir it thoroughly. A certain high temperature helps to increase the solubility of orotic acid.

[0036] Preferably, the zinc oxide suspension is prepared by:

[0037] Take zinc oxide and add it into 2 to 3 times the mass of water and stir thoroughly.

[0038] At the appropriate concentration, there is enough space for orotic acid and zinc oxide to contact, thus improving the reaction effect.

[0039] Preferably, the average particle size of the nano zinc oxide is 20 nm to 30 nm and is nearly spherical, which can ensure that the nano zinc oxide has high activity.

[0040] Preferably, the drying temperature in step S3 is 85° C. to 100° C. and the drying time is 16 h to 18 h. Under such conditions, the zinc orotate can be fully dried without changing the properties of the zinc orotate.

[0041] Example 1

[0042] The preparation method of zinc orotate provided in this embodiment comprises the following steps:

[0043] 1. Add 300 ml of deionized water to a 1L beaker, slowly add 156 g of orotic acid, heat in a 60°C water bath, and stir thoroughly to obtain orotic acid suspension①;

[0044] 2. Add 200 ml of deionized water and 97 g of highly active nano zinc oxide crystals (average particle size of 20 nm to 30 nm, nearly spherical) to another 1 L beaker, and stir well at room temperature to obtain zinc oxide suspension ①;

[0045] 3. Heat the orotic acid suspension ① in step 1 to 95°C, add the zinc oxide suspension ② in step 2 to ① gradually, and after the mixing is completed, add the reaction solution to the circulating reactor and maintain a high temperature of 95°C for 2h;

[0046] 4. After sufficient reaction, the reaction solution was filtered, and the filtrate was stirred with an electric constant speed stirrer at a constant speed of 400 r / s for 12 h, and fully cooled and crystallized;

[0047] 5. After sufficient crystallization, the reaction solution is filtered twice, and then the wet material is dried in a blast drying oven at 90°C for 16 hours to obtain a white crystalline powder of zinc orotate.

[0048] Comparative Example 1

[0049] This comparative example uses ordinary zinc oxide to prepare a zinc orotate product to explore the effects of ordinary zinc oxide and high-activity zinc oxide on the preparation of a zinc orotate product. The specific experimental steps are as follows:

[0050] 1. Add 300 ml of deionized water to a 1L beaker, slowly add 156 g of orotic acid, heat in a 60°C water bath, and stir thoroughly to obtain orotic acid suspension①;

[0051] 2. Add 200 ml of deionized water and 97 g of ordinary zinc oxide (average particle size 3 um to 10 um) to another 1 L beaker, stir well at room temperature to obtain zinc oxide suspension ①;

[0052] 3. Heat the orotic acid suspension ① in step 1 to 95°C, add the zinc oxide suspension ② in step 2 to ① gradually, and after the mixing is completed, add the reaction solution to a small circulation reactor and keep the high temperature at 95°C for 2h;

[0053] 4. After sufficient reaction, the reaction solution was filtered, and the filtrate was stirred with an electric constant speed stirrer at a constant speed of 400 r / s for 12 h, and fully cooled and crystallized;

[0054] 5. After sufficient crystallization, the reaction solution is filtered twice, and then the wet material is dried in a blast drying oven at 90°C for 16 hours to obtain a white crystalline powder of zinc orotate.

[0055] The zinc orotate products of Example 1 and Comparative Example 1 were compared and analyzed, and the analysis results of the effects of common zinc oxide and high-activity raw materials on the zinc orotate products are shown in Table 1.

[0056] Table 1 Effect of using different zinc oxides on the synthetic zinc orotate products

[0057] Sample No. Example 1 Comparative Example 1 Zinc orotate content / % 99.52 90.30 Product yield / % 96.8 82.5

[0058] Comparing the data in Table 1, it can be seen that when ordinary zinc oxide is used to synthesize zinc orotate products, it cannot fully react with orotic acid during the reaction process, resulting in a low content of the generated zinc orotate product and a relatively low product yield. However, when highly active zinc oxide crystals are used to participate in the synthesis reaction, the reaction contact area between the raw materials is increased, the reaction rate is increased, and the reaction can be more fully reacted, thereby making the generated zinc orotate product have a higher content and a higher product yield.

[0059] Comparative Example 2

[0060] Except that in step 3, the mixed material is heated to a reaction temperature of 40° C., the rest is the same as in Example 1.

[0061] Comparative Example 3

[0062] Except that in step 3, the mixed material is heated to 60° C., the rest is the same as in Example 1.

[0063] Comparative Example 4

[0064] Except that in step 3, the mixed material is heated to 80° C., the rest is the same as in Example 1.

[0065] The zinc orotate products of Example 1 and Comparative Examples 2 to 4 were compared and analyzed, and the analysis results of the effects of different reaction temperatures of the mixed materials on the zinc orotate products are shown in Table 2.

[0066] Table 2 Effect of different reaction temperatures on the synthesis of zinc orotate products

[0067] Sample No. Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Reaction temperature / ℃ ＞90℃ 40℃ 60℃ 80℃ Zinc orotate content / % 99.52 35.21 50.30 88.35 Product yield / % 96.8 40.1 62.5 80.2

[0068] Comparing the data in Table 2, it can be seen that the reaction temperature of the composite materials in the process of synthesizing zinc orotate has a great influence on the product content and yield. Increasing the reaction temperature can increase the reaction rate and increase the reaction yield. Therefore, the synthesis reaction temperature of zinc orotate should be maintained at a high temperature of more than 90°C.

[0069] Comparative Example 5

[0070] The raw material addition ratio was changed from the original molar ratio of 1:1.2 to 1:1, and the remaining steps and operations were the same as in Example 1.

[0071] Comparative Example 6

[0072] The raw material addition ratio was changed from the original molar ratio of 1:1.2 to 1:1.3, and the remaining steps and operations were the same as in Example 1.

[0073] Comparative Example 7

[0074] Except that the molar ratio of the raw materials was changed from the original 1:1.2 to 1:1.5, the remaining steps and operations were the same as those in Example 1.

[0075] The zinc orotate products of Example 1 and Comparative Examples 5 to 7 were compared and analyzed, and the analysis results of the effects of different raw material ratios on the zinc orotate products are shown in Table 3.

[0076] Table 3 Effect of different raw material ratios on the synthesis of zinc orotate products

[0077] Sample No. Example 1 Comparative Example 5 Comparative Example 6 Comparative Example 7 Raw material ratio 1:1.2 1:1 1:1.3 1:1.4 Zinc orotate content / % 99.52 95.13 100.75 101.68 Product yield / % 96.8 88.3 92.3 94.5

[0078] Comparing the data in Table 3, it can be seen that the feeding ratio of raw materials will affect the product content and yield. A raw material ratio of less than 1:1.2 will reduce the content of zinc orotate product and the yield will also decrease accordingly. A raw material ratio of more than 1:1.2 will react more fully to a certain extent, but will not have much effect on improving the content and yield of zinc orotate product. Therefore, the feeding ratio of raw materials should be between 1:1.2 and 1.4, preferably 1:1.2.

[0079] Comparative Example 8

[0080] Except that in step 4, constant speed stirring is not performed, the rest is the same as in Example 1.

[0081] Comparative Example 9

[0082] Except for step 4, the constant stirring speed is changed to 200 r / s, and the rest is the same as in Example 1.

[0083] Comparative Example 10

[0084] Except for step 4, the constant speed stirring speed is changed to 600r / s, and the rest is the same as embodiment 1.

[0085] The zinc orotate products of Example 1 and Comparative Examples 8 to 10 were compared and analyzed, and the analysis results of the effects of different constant stirring speeds on the zinc orotate products are shown in Table 4.

[0086] Table 4 Effect of different constant stirring speeds on the synthesis of zinc orotate products

[0087] Sample No. Example 1 Comparative Example 8 Comparative Example 9 Comparative Example 10 Constant stirring speed r / s 400 0 200 600 Product yield / % 96.8 80.2 91.7 97.2 Solubility g / 100ml 3.2 0.2 1.2 2.8

[0088] Comparing the data in Table 4, it can be seen that different constant stirring speeds have a greater influence on the yield of synthesized zinc orotate. The faster the stirring speed, the more product precipitates and the higher the product yield. However, when the stirring speed is too fast, the precipitated product will become viscous, making it difficult to separate the water material and dry the material, resulting in excessive moisture in the product, which will reduce the solubility of the product. Therefore, in the reaction process of synthesizing zinc orotate, the constant stirring speed should be controlled in the range of 350r / s to 550r / s, and the product solubility can be >3g / 100mL.

[0089] Comparative Example 11

[0090] Except that in step 5, the drying temperature is changed to 60° C., the rest is the same as in Example 1.

[0091] Comparative Example 12

[0092] Except that in step 5, the drying temperature is changed to 80° C., the rest is the same as in Example 1.

[0093] Comparative Example 13

[0094] Except that in step 5, the drying temperature is changed to 100° C., the rest is the same as in Example 1.

[0095] The zinc orotate products of Example 1 and Comparative Examples 11 to 13 were compared and analyzed, and the analysis results of the effects of different drying conditions on the synthesis of easily soluble zinc orotate products are shown in Table 5.

[0096] Table 5 Effect of different drying conditions on the synthetic zinc orotate product

[0097] Sample No. Example 1 Comparative Example 11 Comparative Example 12 Comparative Example 13 Drying temperature 90 60 80 100 Zinc orotate content / % 99.52 98.25 98.57 98.13 Loss on drying / % 0.33 10.34 5.12 0.30 Solubility g / 100ml ＞10 ＜10 ＜10 ＞10

[0098] The crystal water of the product will be lost only under certain temperature conditions, and the effect of removing crystal water cannot be increased by simply extending the reaction time. Comparative Table 5 shows that different drying conditions have a greater impact on the moisture content of the synthesized zinc orotate product. The higher the drying temperature, the lower the moisture content of the zinc orotate product, and the better the solubility of the corresponding product. However, the degree of reduction in the moisture content of the product is no longer obvious when the drying temperature is greater than 95°C. Considering the synthesis cost of the product, the product drying temperature should be greater than 95°C, preferably in the range of 85°C to 95°C.

[0099] Example 2

[0100] The preparation method of zinc orotate provided in this embodiment comprises the following steps:

[0101] 1. Add 300 ml of deionized water to a 1L beaker, slowly add 156 g of orotic acid, heat in a 60°C water bath, and stir thoroughly to obtain orotic acid suspension①;

[0102] 2. Add 200 ml of deionized water and 97 g of highly active zinc oxide crystals to another 1L beaker, stir thoroughly at room temperature to obtain zinc oxide suspension ①;

[0103] 3. Heat the orotic acid suspension ① in step 1 to 95°C, add the zinc oxide suspension ② in step 2 to ① gradually, and after the mixing is completed, add the reaction solution to a small circulation reactor and keep the high temperature at 95°C for 2h;

[0104] 4. After sufficient reaction, the reaction solution was filtered, and the filtrate was stirred with an electric constant speed stirrer at a constant speed of 350 rpm for 12 h, and fully cooled and crystallized;

[0105] 5. After sufficient crystallization, the reaction solution is filtered twice, and then the wet material is dried in a blast drying oven at 90°C for 16 hours to obtain a white crystalline powder of zinc orotate.

[0106] Example 3

[0107] The preparation method of zinc orotate provided in this embodiment comprises the following steps:

[0108] 1. Add 300 ml of deionized water to a 1L beaker, slowly add 156 g of orotic acid, heat in a 60°C water bath, and stir thoroughly to obtain orotic acid suspension①;

[0109] 2. Add 200 ml of deionized water and 97 g of highly active zinc oxide crystals to another 1L beaker, stir thoroughly at room temperature to obtain zinc oxide suspension ①;

[0110] 3. Heat the orotic acid suspension ① in step 1 to 95°C, add the zinc oxide suspension ② in step 2 to ① gradually, and after the mixing is completed, add the reaction solution to a small circulation reactor and keep the high temperature at 95°C for 2h;

[0111] 4. After sufficient reaction, the reaction solution was filtered, and the filtrate was stirred with an electric constant speed stirrer at a constant speed of 450 rpm for 12 h, and fully cooled and crystallized;

[0112] 5. After sufficient crystallization, the reaction solution is filtered twice, and then the wet material is dried in a blast drying oven at 90°C for 16 hours to obtain a white crystalline powder of zinc orotate.

[0113] Example 4

[0114] The preparation method of zinc orotate provided in this embodiment comprises the following steps:

[0115] 1. Add 300 ml of deionized water to a 1L beaker, slowly add 156 g of orotic acid, heat in a 60°C water bath, and stir thoroughly to obtain orotic acid suspension①;

[0116] 2. Add 200 ml of deionized water and 97 g of highly active zinc oxide crystals to another 1L beaker, stir thoroughly at room temperature to obtain zinc oxide suspension ①;

[0117] 3. Heat the orotic acid suspension ① in step 1 to 95°C, add the zinc oxide suspension ② in step 2 to ① gradually, and after the mixing is completed, add the reaction solution to a small circulation reactor and keep the high temperature at 95°C for 2h;

[0118] 4. After sufficient reaction, the reaction solution was filtered, and the filtrate was stirred with an electric constant speed stirrer at a constant speed of 500 rpm for 12 h, and fully cooled and crystallized;

[0119] 5. After sufficient crystallization, the reaction solution is filtered twice, and then the wet material is dried in a blast drying oven at 90°C for 16 hours to obtain a white crystalline powder of zinc orotate.

[0120] Example 5

[0121] The preparation method of zinc orotate provided in this embodiment comprises the following steps:

[0122] 1. Add 300 ml of deionized water to a 1L beaker, slowly add 156 g of orotic acid, heat in a 60°C water bath, and stir thoroughly to obtain orotic acid suspension①;

[0123] 2. Add 200 ml of deionized water and 97 g of highly active zinc oxide crystals to another 1L beaker, stir thoroughly at room temperature to obtain zinc oxide suspension ①;

[0124] 3. Heat the orotic acid suspension ① in step 1 to 95°C, add the zinc oxide suspension ② in step 2 to ① gradually, and after the mixing is completed, add the reaction solution to a small circulation reactor and keep the high temperature at 95°C for 2h;

[0125] 4. After sufficient reaction, the reaction solution was filtered, and the filtrate was stirred with an electric constant speed stirrer at a constant speed of 550 rpm for 12 h, and fully cooled and crystallized;

[0126] 5. After sufficient crystallization, the reaction solution is filtered twice, and then the wet material is dried in a blast drying oven at 90°C for 16 hours to obtain a white crystalline powder of zinc orotate.

[0127] The products obtained in Examples 2 to 5 were tested respectively, and the results are shown in Table 6.

[0128] Table 6 Data of zinc orotate product synthesized in Example

[0129] Sample No. Example 2 Example 3 Example 4 Example 5 Zinc orotate content / % 99.52 99.31 99.53 99.68 Loss on drying / % 0.33 0.34 0.36 0.31 Product yield / % 96.35 96.84 97.01 97.23 Solubility g / 100ml 12.1 12.6 12.8 13.0

[0130] Example 6

[0131] The preparation method of zinc orotate provided in this embodiment comprises the following steps:

[0132] 1. Add 300 ml of deionized water to a 1L beaker, slowly add 156 g of orotic acid, heat in a 60°C water bath, and stir thoroughly to obtain orotic acid suspension①;

[0133] 2. Add 200 ml of deionized water and 97 g of highly active zinc oxide crystals to another 1L beaker, stir thoroughly at room temperature to obtain zinc oxide suspension ①;

[0134] 3. Heat the orotic acid suspension ① in step 1 to 95°C, add the zinc oxide suspension ② in step 2 to ① gradually, and after the mixing is completed, add the reaction solution to a small circulation reactor and maintain a high temperature of 93°C for 2.5 hours;

[0135] 4. After sufficient reaction, the reaction solution was filtered, and the filtrate was stirred with an electric constant speed stirrer at a constant speed of 400 rpm for 14 h, and fully cooled and crystallized;

[0136] 5. After sufficient crystallization, the reaction solution is filtered twice, and then the wet material is dried in a blast drying oven at 95°C for 16 hours to obtain a white crystalline powder of zinc orotate.

[0137] Although preferred embodiments of the present invention have been described, additional changes and modifications may be made to these embodiments by those skilled in the art once the basic inventive concepts are known. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments and all changes and modifications that fall within the scope of the present invention. Obviously, those skilled in the art may make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include these modifications and variations.

Claims

1. A method for preparing zinc orotate, characterized in that: The following steps are involved: S1. Take orotic acid and zinc oxide and fully react them in water to generate zinc orotic acid. The reaction method is a high-temperature cycle reaction, the reaction temperature is above 90°C, and the reaction time is 2h to 3h; the zinc oxide is nano zinc oxide; the molar ratio of the orotic acid to the zinc oxide is 1:(1.2 to 1.4); S2. Solid-liquid separation, taking the separated liquid phase and stirring it continuously at 350r / s to 550r / s for 12h to 16h to allow zinc orotate to be fully cooled and crystallized; S3. The reaction solution is then separated into solid and liquid again, and the solid phase is dried to obtain zinc orotate.

2. The method for preparing zinc orotate according to claim 1, wherein The reaction in step S1 is carried out in a circulation reactor.

3. The method for preparing zinc orotate according to claim 2, characterized in that, First, an orotic acid suspension and a zinc oxide suspension are prepared, and the orotic acid suspension is heated to above 90° C., and then the zinc oxide suspension is slowly added to the orotic acid suspension. After mixing, the mixed solution is added to the circulation reactor for reaction.

4. The method for preparing zinc orotate according to claim 3, characterized in that: The preparation steps of the zinc orotate suspension are as follows: Take orotic acid and add it into 1.5 to 2.5 times the mass of water, heat to 50°C to 70°C, and stir thoroughly.

5. The method for preparing zinc orotate according to claim 3, characterized in that: The zinc oxide suspension preparation steps are: Take zinc oxide and add it into 2 to 3 times the mass of water and stir thoroughly.

6. The method for preparing zinc orotate according to claim 1, characterized in that: The nano zinc oxide has an average particle size of 20nm to 30nm and is nearly spherical.

7. The method for preparing zinc orotate according to claim 1, characterized in that: Step S2 uses circulating cooling water to cool to room temperature.

8. The method for preparing zinc orotate according to claim 1, characterized in that: The drying temperature in step S3 is 85° C. to 100° C. and the drying time is 16 h to 18 h.

9. The method for preparing zinc orotate according to claim 1, characterized in that: The solid-liquid separation method adopts a filtration method.