Sample analyzer

Abstract

The invention provides a sample analyzer, which is characterized in that a sampling distribution module is used for sucking a blood sample from a sample tube and distributing the blood sample to a glycosylated hemoglobin detection module and a glucose detection module; the glycosylated hemoglobin detection module is used for obtaining glycosylated hemoglobin parameters of the blood sample; the glucose detection module comprises a test strip supply mechanism and a second detector, the test strip supply mechanism is used for supplying test strips to enable the test strips to receive the distributed blood samples, and the second detector is used for being electrically connected with the test strips distributed with the blood samples to detect and obtain glucose parameters of the blood samples. Glucose detection and glycosylated hemoglobin detection can be achieved at the same time, the test strip is adopted for blood glucose detection, and the advantages of being low in sample consumption, small in pollution risk and high in detection flux are achieved.

Description

Technical Field

[0001] The present invention relates to the field of in vitro diagnosis, and in particular to a sample analyzer. Background Art

[0002] Currently, when doctors in clinical departments find that a patient's blood sugar is abnormal, they usually still need to test the patient's glycosylated hemoglobin content, and use the two results together to diagnose the patient and formulate the next treatment plan. For physical examination patients, blood sugar and glycosylated hemoglobin are often tested at the same time. When the operating teacher in the laboratory department finds that the glycosylated hemoglobin result of a sample is abnormal, in addition to retesting the sample, he will also pay attention to the patient's blood sugar result for joint judgment.

[0003] Currently, glycated hemoglobin testing and blood sugar testing are performed using different instruments, which requires multiple blood draws from patients. The existing technology needs to be improved and developed. Summary of the invention

[0004] In view of the above problems, the present invention provides a sample analyzer which can detect glycated hemoglobin and blood sugar at the same time.

[0005] The sample analyzer comprises: a sampling distribution module, a glycated hemoglobin detection module and a glucose detection module; the sampling distribution module is used to obtain a blood sample from a target sample tube and distribute the blood sample to the glycated blood sugar protein detection module and the glucose detection module; the glycated hemoglobin detection module comprises a reaction pool, a chromatographic column and a first detector, the reaction pool is used for the blood sample to react with a reagent to form a sample liquid to be tested, the chromatographic column is used to separate components in the sample liquid to be tested, and the first detector is used to detect the separated components to obtain the glycated hemoglobin parameters of the blood sample; the glucose detection module comprises a test strip supply mechanism and a second detector, the test strip supply mechanism is used to supply a test strip to a sample dropping position, the test strip at the sample dropping position is used to receive the blood sample, and the second detector is used to be electrically connected to the test strip at the sample dropping position to detect and obtain the glucose parameters of the blood sample.

[0006] In one embodiment, the test strip supply mechanism includes a test strip storage container and a test strip transfer mechanism. The test strip storage container is used to store test strips. The test strip transfer mechanism is used to transfer the test strips in the test strip storage container to the sample dropping position one by one.

[0007] In one embodiment, the test strip transfer mechanism includes any one of a gripper, a suction cup, or a pusher.

[0008] In one embodiment, the test strip supply mechanism includes a strip selection mechanism and a strip transport mechanism; the strip selection mechanism is used to store the test strips and output the test strips one by one to the strip transport mechanism; the strip transport mechanism is used to transport the test strips output by the strip selection mechanism to the sample dropping position; the sampling distribution module is configured to distribute part of the blood sample to the test strip located at the sample dropping position.

[0009] In one embodiment, the strip selection mechanism includes a shell and a rotating roller, the top of the shell is provided with a receiving groove, the rotating roller is arranged inside the shell, and the rotating roller is located below the receiving groove, the circumferential surface of the rotating roller is provided with a groove, and the groove can only accommodate one test strip, and the rotating roller rotates to bring the test strip that falls into the groove from the receiving groove out of the shell, so as to output the test strip to the strip transport mechanism.

[0010] In one embodiment, the test strip transport mechanism includes a pushing assembly and a first carrying plate, the first carrying plate is used to carry the test strip, and the pushing assembly is used to push the test strip to move on the first carrying plate.

[0011] In one embodiment, the second detector includes a detection head and a second driving assembly, and the second driving assembly is used to drive the detection head to move so that the detection head is electrically connected to the test strip at the sample dropping position.

[0012] In one embodiment, the glucose detection module further includes a blocking mechanism, which is used to cooperate with the test strip supply mechanism to position the test strip at the sample dropping position.

[0013] In one embodiment, the blocking mechanism includes a block and a third drive assembly, the third drive assembly is used to drive the block to block the test strip from continuing to move, the third drive assembly includes a second power assembly and a transmission assembly, and the second power assembly drives the block to move through the transmission assembly.

[0014] In one embodiment, the second detector includes a detection head and a second drive assembly, the second drive assembly includes a first power assembly, the first power assembly is used to drive the detection head to move so that the detection head is electrically connected to the test strip, and the second power assembly is the same power assembly as the first power assembly.

[0015] In one embodiment, the transmission assembly includes a detection support plate, a flip block and a rotating shaft. The detection support plate is rotatably connected to the rotating shaft, and the flip block and the stop block are both connected to the rotating shaft. The second power assembly is used to drive the flip block to rotate, thereby driving the stop block to rotate to limit the test strip.

[0016] In one embodiment, the transmission assembly further includes a roller, which is mounted on the second power assembly and fits the flip block. The second power assembly drives the roller to move in a direction perpendicular to the rotation axis to drive the flip block to rotate.

[0017] In one embodiment, the flip block is connected to a tension spring, and the tension spring is used to drive the flip block to reset.

[0018] In one embodiment, the glucose detection module further includes a recovery module, which includes a recovery box disposed at an output end of the test strip supply mechanism, and the recovery box is used to receive and store the test strips that have completed the test.

[0019] In one embodiment, the recycling module also includes a conveying mechanism, which is provided with a working position and a box return cache position. The working position is arranged at the output end of the test strip supply mechanism. The conveying mechanism is used to drive the recycling box to move, so that the fully loaded recycling box at the working position moves to the box return cache position.

[0020] In one embodiment, the recycling module further includes a conveying mechanism, which is provided with a working position and a spare buffer position, the spare buffer position is used to place a spare recycling box, and the conveying mechanism is also used to drive the recycling box on the spare buffer position to move to the working position.

[0021] In one embodiment, it also includes an injection module, which is used to transport the target sample tube to the sampling position of the sampling distribution module. The sampling position, reaction pool and dripping position of the glucose detection module are located in sequence on the horizontal movement path of the sampling needle, and the horizontal movement path of the sampling needle is a straight path.

[0022] In one embodiment, the injection module can transport a sample rack carrying conventional sample tubes along a first direction, where the first direction is the length direction of the sample rack; the paper strip supply mechanism is used to transfer the test strip to the sample dropping position along a second direction, where the first direction is parallel to the second direction.

[0023] In one embodiment, projections of the reaction pool and the injection module on the horizontal plane overlap.

[0024] In one embodiment, a control module is further included, which is communicatively connected with the sampling and distribution module, the glycated hemoglobin detection module and the glucose detection module. The control module is configured to control the sampling and distribution module to collect blood samples from the target sample tube, and then control the sampling and distribution module to first distribute the samples to the reaction pool in the glycated hemoglobin detection module, and then distribute the samples to the dripping position of the glucose detection module.

[0025] In one embodiment, the control module is configured to control the glucose detection module to complete the preparation work before or at the same time as controlling the sampling distribution module to distribute the sample to the reaction pool of the saccharification detection module, wherein the preparation work includes moving the test paper to the sample dropping position and electrically connecting the second detector to the test paper.

[0026] In one embodiment, the amount of blood sample for glucose detection is 0.3-3 ul, and the amount of blood sample for glycated hemoglobin detection is 3-8 ul.

[0027] In one embodiment, the glycated hemoglobin detection module also includes an eluent supply component, a hemolytic agent supply component, and an injection valve. The eluent supply component can provide eluents with different composition ratios, and can bring the quantified sample liquid to be tested in the quantitative loop of the injection valve into the chromatographic column through the eluent for gradient elution to separate the components in the sample liquid to be tested. The first detector is used to detect the separated components, and after detecting the absorbance of each component, a chromatogram is formed through data processing to obtain the parameters of glycated hemoglobin.

[0028] By adopting the above scheme, glycated hemoglobin and blood sugar can be tested at the same time, and the blood sugar test is tested with a test strip, which requires a small amount of sample and has a low test cost. In the glucose detection module, it is not necessary to set up a reusable detection pipeline, which reduces the carryover contamination rate of glucose detection, saves time for cleaning the glucose detection pipeline, and improves the detection throughput. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0030] Figure 1 A schematic diagram of a sampling needle movement path and a test strip transport path according to an embodiment of the present invention is shown.

[0031] Figure 2 A schematic diagram of the fluid path of a glycated hemoglobin detection module according to an embodiment of the present invention is shown.

[0032] Figure 3 A three-dimensional structural diagram of a sample analyzer according to an embodiment of the present invention is shown.

[0033] Figure 4 A left side structural diagram of a sample analyzer according to an embodiment of the present invention is shown.

[0034] Figure 5 A top view of a sample analyzer according to an embodiment of the present invention is shown.

[0035] Figure 6 A schematic diagram of the structure of a glucose detection module according to an embodiment of the present invention is shown.

[0036] Figure 7 A structural schematic diagram of a strip selection mechanism according to an embodiment of the present invention is shown.

[0037] Figure 8A perspective view of a strip transport structure according to an embodiment of the present invention is shown.

[0038] Fig. 9 A front view of a strip transport structure according to an embodiment of the present invention is shown.

[0039] Fig.10 A schematic structural diagram of a second detector and a blocking mechanism according to an embodiment of the present invention is shown.

[0040] Fig.11 A schematic structural diagram of a blocking mechanism according to an embodiment of the present invention is shown.

[0041] Fig.12 A schematic diagram of the structure of a recycling module according to an embodiment of the present invention is shown.

[0042] Fig.13 A schematic diagram of the structure of a test strip according to an embodiment of the present invention is shown.

[0043] Reference numerals:

[0044] 1. Glycated hemoglobin detection module; 11. Reaction pool; 12. First detector; 13. Chromatographic column; 14. Eluent supply assembly; 141. Eluent A storage bottle; 142. Eluent B storage bottle; 143. Degasser; 144. Proportional valve; 145. High-pressure pump; 146. Damper; 15. Injection valve; 151. Quantitative loop;

[0045] 2. Glucose detection module; 21. Bar selection mechanism; 211. Rotating roller; 2111. Groove; 212. Screen bar assembly;

[0046] 22, strip transport mechanism; 221, push plate; 222, synchronous belt; 223, spring; 224, first bearing plate; 2241, strip through hole; 225, guide block; 226, drive plate; 227, push support plate; 2271, slide rail;

[0047] 23. Second detector; 231. Detection head; 232. Screw motor; 233. Mounting plate; 234. Connecting plate;

[0048] 24. blocking mechanism; 241. stopper; 242. detection support plate; 243. flip block; 244. rotating shaft; 245. rotating bushing; 246. roller; 247. tension spring;

[0049] 25, recycling module; 251, recycling box; 2521, fourth driving assembly; 2522, fifth driving assembly; 2531, box-input push plate; 2532, box-output push plate; 2541, first detection photoelectric; 2542, second detection photoelectric; 2543, third detection photoelectric; 255, limit stopper;

[0050] 3. Injection module;

[0051] 4. Sampling distribution module; 41. Sampling needle;

[0052] 5. Test strip; 51. Sample drop area; 52. Contact area;

[0053] 6. Sample rack; 7. Sample tube. DETAILED DESCRIPTION

[0054] The embodiments of the present invention are described in detail below. The embodiments described below are exemplary and are only used to explain the present invention, and should not be construed as limiting the present invention. If no specific techniques or conditions are specified in the embodiments, the techniques or conditions described in the literature in the art or the product specifications are used.

[0055] In one aspect of the present invention, the present invention provides a sample analyzer. In some embodiments of the present invention, reference Figure 1 , Figure 2 and Figure 3 , the sample analyzer includes: a sampling distribution module 4, a glycosylated hemoglobin detection module 1 and a glucose detection module 2;

[0056] See also Figure 1 and Figure 3 As shown, the sampling distribution module 4 is used to collect blood samples from the target sample tube 7 and distribute the blood samples to the glycated hemoglobin detection module 1 and the glucose detection module 2; specifically, the blood samples are whole blood samples.

[0057] See also Figure 1 , Figure 2 as well as Figure 4 As shown, the glycated hemoglobin detection module 1 comprises a reaction pool 11, a chromatographic column 13 and a first detector 12. The reaction pool 11 is used for the distributed blood sample to react with the reagent to form a sample liquid to be tested. The chromatographic column 13 is used to separate the components in the sample liquid to be tested. The first detector 12 is used to detect the separated components to obtain the glycated hemoglobin parameters of the blood sample.

[0058] The glucose detection module 2 includes a test strip 5 and a second detector 23. Fig.13As shown, the test strip 5 includes a dripping area 51, a reaction area and a contact area 52, wherein the dripping area 51 is used to receive the distributed blood sample, the reaction area is provided with an enzyme coating for reacting with the blood sample, and the second detector 23 is electrically connected to the contact area 52 for detecting the glucose parameter of the blood sample. The dripping area 51 and the reaction area can be the same area, that is, the contact area 52 is directly provided with an enzyme coating; the dripping area 51 and the reaction area can be different areas. When the dripping area 51 and the reaction area are different areas, a fluid channel is provided between the two areas, and the blood sample in the dripping area 51 can reach the reaction area by siphoning or the like, and react with the enzyme coating in the reaction area.

[0059] By adopting the above scheme, glycated hemoglobin and blood sugar can be tested at the same time, and the blood sugar test is tested by using the test strip 5, the required sample amount is small, and the consumables for glucose testing are only the test strip 5, and the testing cost is low. There is no need to set a reusable detection pipeline in the glucose detection module 2, which reduces the carryover contamination rate of glucose detection, saves time for cleaning the glucose detection pipeline, and improves the detection throughput.

[0060] The detection principle of the glucose detection module 2 is: the blood sample reacts chemically with the enzyme coating to release electrons, which generate a tiny current, the magnitude of which is proportional to the glucose concentration in the blood sample, and the blood sugar content can be calculated by collecting the electrical signal. The enzyme coating can be a glucose oxidase coating or a glucose dehydrogenase coating.

[0061] In some embodiments of the present invention, the test strip 5 is further provided with a first electrode and a second electrode, one end of the first electrode and the second electrode is located in the reaction zone, and the other end of the first electrode and the second electrode is located in the contact zone 52. The second detector is electrically connected to the contact zone 52, and forms a glucose detection circuit with the first electrode and the second electrode, which is used to detect the electrical signal generated by the chemical reaction between the blood sample and the enzyme coating in the reaction zone to detect the glucose parameter. In some embodiments of the present invention, the glucose detection module 2 also includes a test strip supply mechanism, which is used to supply the test strips 5 to the sample dripping position one by one, and the test strip supply mechanism may include a test strip storage container and a test strip transfer mechanism, and a plurality of test strips 5 are neatly placed in the test strip 5 storage container, and the test strip transfer mechanism is used to transfer the test strips 5 in the test strip storage container to the sample dripping position one by one to participate in the detection.

[0062] In some embodiments of the present invention, the test strip transfer mechanism may be a gripper, a suction cup, a pusher, etc. Compared with pushing the test strip 5, the transfer of the test strip 5 can be completed more flexibly.

[0063] In some embodiments of the present invention, Figure 5 as well as Figure 6 As shown, the test strip supply mechanism includes a strip selection mechanism 21 and a strip transport mechanism 22. The strip selection mechanism 21 is used to store the test strips 5 and output the test strips 5 one by one to the strip transport mechanism 22. The strip transport mechanism 22 is used to transport the test strips 5 output by the strip selection mechanism 21 to the sample dropping position.

[0064] The test strips 5 are output one by one through the strip selection mechanism 21 , thereby avoiding the need to simultaneously deliver multiple test strips 5 to the sample dropping position, and reducing the consumption of the test strips 5 .

[0065] In some embodiments of the present invention, Figure 5 As shown, the strip selection mechanism 21 is arranged adjacent to the sample injection module 3 and close to a side panel of the sample analyzer housing, and a first side door is provided on a side panel of the sample analyzer housing, through which the operator can add the test strip 5 to the strip selection mechanism 21. With this solution, when the operator stands in front of the analyzer, it is convenient to add the sample tube 7 to the sample injection module 3, and it is also convenient to add the test strip 5 to the strip selection mechanism 21 from the first side door, thereby improving the convenience of operation.

[0066] See also Figure 6 as well as Figure 7 As shown, in some embodiments of the present invention, the strip selection mechanism 21 includes a shell, a test strip accommodating groove arranged on the top of the shell and a rotating roller 211 arranged inside the shell, and one or more grooves 2111 are provided on the circumferential outer surface of the rotating roller 211, and the grooves 2111 are arranged along the axial direction of the rotating roller 211, and the grooves 2111 can only accommodate one test strip 5; the rotating roller 211 rotates to bring the test strip 5 that falls into the groove 2111 from the accommodating groove out of the shell and output it to the strip selection mechanism 21.

[0067] The strip selection mechanism 21 also includes a screen bar assembly 212, which is used to screen the test strips on the rotating roller 211, so as to intercept the test strips 5 outside the groove 2111. In the rotation direction of the rotating roller 211, the screen bar assembly 212 is located in front of the test strip receiving groove. When the test strip 5 falls from the test strip receiving groove to the top of the rotating roller 211, the rotating roller 211 will rotate and drive the test strip 5 to gradually transport toward the screen bar assembly 212, and the test strip 5 is screened by the screen bar assembly 212. It can be understood that the distance from the screen bar assembly 212 to the outer peripheral surface of the rotating roller 211 is less than the thickness of the test strip 5, so as to avoid the test strip 5 outside the groove 2111 from being directly sent out from the gap between the screen bar assembly 212 and the outer peripheral surface of the rotating roller 211.

[0068] When the sieve bar assembly 212 is used to select the test strips, two situations may occur. In the first situation, the test strip 5 is just inserted into the groove 2111, and the test strip 5 inserted into the groove 2111 can pass through the sieve bar assembly 212 smoothly. When the test strip 5 is not inserted into the groove 2111, the sieve bar assembly 212 helps to filter out the test strip 5 that is not in the groove 2111. Specifically, when the test strip 5 is not inserted into the groove 2111, the sieve bar assembly 212 can not only filter out the test strip 5 that is not in the groove 2111, but also push the test strip 5 at the edge of the groove 2111 into the groove 2111, so that the test strips 5 are output one by one from the strip selection mechanism 21, so that the test strips 5 can be subsequently tested.

[0069] That is to say, the test strips 5 are selected by rotating the rotating roller 211 with the groove 2111 , so that the test strips 5 in the test strip receiving slot are selected one by one so that the test strip transport mechanism 22 can transport the test strips 5 .

[0070] In some embodiments of the present invention, the strip transport mechanism 22 includes a first carrier plate 224 and a push assembly, wherein the first carrier plate 224 is used to carry the test strips 5, and the push assembly is used to push the test strips 5 to move on the first carrier plate 224. After the test strips 5 are selected, they enter the strip transport mechanism 22 one by one. In the present application, the test strips 5 entering the strip transport mechanism 22 one by one are transferred and transported by pushing. Compared with direct transportation by a conveyor belt, the risk of the test strips 5 being stuck during transportation can be reduced, and the transportation speed of the test strips 5 can be accurately controlled by controlling the pushing speed of the push assembly.

[0071] Among them, in some implementations, guide blocks 225 for guiding the movement of the test strip 5 are provided on both sides of the first carrier plate 224 along the conveying direction; the first carrier plate 224 is provided with a strip-shaped through hole 2241 along the pushing direction, and the strip-shaped through hole 2241 is at least two; the pushing assembly includes a pushing support plate 227, a push plate 221 installed on the pushing support plate 227, and a first driving assembly, wherein the push plate 221 is slidably arranged on the pushing support plate 227 through a slide rail 2271, and the first driving assembly can drive the push plate 221 to move in the strip-shaped through hole 2241. The push plate 221 is located in the strip-shaped through hole 2241 of the first carrier plate 224, and is symmetrically distributed at two positions near the head and tail of the side surface of the test strip 5, and pushes the test strip 5 in parallel, and cooperates with the guide blocks 225 on both sides of the first carrier plate 224, so as to ensure that the test strip 5 is smoothly transported in the entire transportation mechanism and can accurately reach the sample dropping position.

[0072] Since the push support plate 227 is provided with a slide rail 2271 , and the slide rail 2271 cooperates with the push plate 221 , the precision of the moving direction of the push plate 221 can be improved, thereby improving the precision of the transfer direction of the test strip 5 .

[0073] In some embodiments of the present invention, the first driving component may be a synchronous belt 222 transmission component, the push plate 221 is connected to the synchronous belt 222 of the synchronous belt 222 transmission component, and the push plate 221 follows the movement of the synchronous belt 222 to move inside the strip-shaped through hole 2241 .

[0074] In some embodiments of the present invention, Figure 8 as well as Fig. 9 As shown, the pushing assembly also includes a driving plate 226, and the pushing block is connected to the synchronous belt 222 through the driving plate 226, and the connected synchronous belt 222 moves synchronously with it. The pushing plate 221 and the driving plate 226 are flexibly matched through the guide shaft and the compression spring; the pushing plate 221 adopts a flexible design. After the pushing plate 221 pushes the test strip 5 to the sample dripping position, one side of the test strip 5 contacts the test paper stopper 241, and the opposite side contacts the pushing plate 221. The spring 223 has a certain elastic deformation, and the pushing plate 221 exerts a certain pressure on the test strip 5, which can ensure the accurate positioning of the test strip 5 on the first supporting plate 224.

[0075] In some embodiments of the present invention, Fig.10 as well as Fig.11 The glucose detection module 2 further includes a blocking mechanism 24, which is used to cooperate with the test strip supply mechanism to position the test strip 5 at the sample dripping position. The test strip 5 is positioned at the sample dripping position by the blocking mechanism 24, which improves the positioning accuracy of the test strip 5 and avoids the movement of the test strip 5 at the sample dripping position. It can ensure that the sampling distribution module can smoothly distribute the sample to the sample dripping area 51 of the test strip 5, and at the same time ensure that the second detector 23 is stably electrically connected to the test strip 5 at the sample dripping position.

[0076] In some embodiments of the present invention, the blocking mechanism 24 includes a block 241 and a third drive assembly, and the third drive assembly is used to drive the block 241 to block the test strip 5 from continuing to move. The third drive assembly includes a second power assembly and a transmission assembly. The second power assembly drives the block 241 to move through the transmission assembly. Specifically, the third drive assembly can drive the block 241 to move vertically or rotate to approach the first bearing plate 224, or drive the block 241 to extend horizontally, etc., to achieve driving the block 241 to block the test strip 5 from continuing to move, which is not limited here.

[0077] In some embodiments of the present invention, Fig.10 and Fig.11 As shown, the second detector 23 includes a detection head 231 and a second driving assembly, and the second driving assembly is used to drive the detection head 231 to move so that the detection head 231 is electrically connected to the contact area 52 of the test strip 5.

[0078] The second driving assembly includes a mounting plate 233, a connecting plate 234 and a first power assembly, wherein the connecting plate 234 is vertically slidably disposed on the mounting plate 233, the detecting head 231 is mounted on the connecting plate 234, and the power assembly is used to drive the connecting plate 234 to move vertically relative to the mounting plate 233, so as to drive the detecting head 231 to move downward and be electrically connected to the contact area 52 of the test strip 5. The first power assembly can be a screw motor 232, a linear motor, etc., as long as it can make the connecting plate 234 move vertically.

[0079] In some embodiments of the present invention, the first power assembly and the second power assembly are the same power assembly, which can simplify the instrument structure, save installation space, and save costs.

[0080] In some embodiments of the present invention, the transmission assembly includes a detection support plate 242, a flip block 243 and a rotating shaft 244, the detection support plate 242 is rotatably connected to the rotating shaft 244, the flip block 243 and the stop block 241 are both connected to the rotating shaft 244, and the second power assembly is used to drive the flip block 243 to rotate, thereby driving the stop block 241 to rotate to limit the test strip 5.

[0081] That is, the second power assembly drives the flip block 243 to rotate, so that the rotating shaft 244 connected to the flip block 243 rotates synchronously, thereby driving the stopper 241 connected to the rotating shaft 244 to rotate, so that the second power assembly and the stopper 241 can be staggered. Since the second power assembly does not need to directly drive the stopper 241 to rotate, the spacing between the second power assembly and the stopper 241 can be adapted by setting the rotating shaft 244 of different lengths.

[0082] See also Fig.10 and Fig.11 As shown, in some embodiments of the present invention, the transmission assembly further includes a roller 246, the roller 246 is mounted on the second power assembly, and the roller 246 is in contact with the flip block 243, and the second power assembly drives the roller 246 to move in a direction perpendicular to the rotating shaft 244 to drive the flip block 243 to rotate. Since the transmission assembly further includes the roller 246, the second power assembly can drive the roller 246 to move linearly to drive the flip block 243 to rotate, thereby realizing the rotation of the stopper 241 and completing the positioning of the test strip 5.

[0083] Since the first power component that drives the detection head 231 to move linearly and the second power component that drives the roller 246 to move linearly are the same power component, and the driving directions of both are also linear movement, the detection head 231 can be driven synchronously during the process of the power component driving the roller 246 to move downward.

[0084] Since the roller 246 and the detection head 231 are driven by the same power assembly, the stroke lengths of the roller 246 and the detection head 231 are consistent. Using a conventional transmission assembly will cause the rotation angle of the stopper 241 to be related to the stroke accuracy of the detection head 231, affecting the positioning effect of the stopper 241.

[0085] In the above embodiment, since the second power assembly is used to drive the roller 246 to move in a direction perpendicular to the rotating shaft 244, during the downward movement of the roller 246, the roller 246 will first drive the contact surface of the flip block 243 to rotate downward. As the roller 246 gradually moves downward, the contact surface of the flip block 243 will eventually rotate to be parallel to the displacement direction of the roller 246, and then the downward movement of the roller 246 can no longer further drive the rotation of the flip block 243. In other words, since the roller 246 is used to drive the flip block 243 to rotate, the rotation angle of the flip block 243 can be fixed each time, thereby ensuring that the stopper 241 rotates to a specific angle to achieve the positioning of the test strip 5.

[0086] In some embodiments of the present application, Fig.11 As shown, the flip block 243 is connected to a tension spring 247, and the tension spring 247 is used to drive the flip block 243 to reset. Through the elastic force of the tension spring 247, it can be ensured that the contact surface of the flip block 243 is always in contact with the roller 246.

[0087] In order to more clearly explain how the blocking mechanism 24 achieves blocking positioning of the test strip 5, the blocking process of the blocking mechanism 24 is further described below:

[0088] like Fig.10 As shown, it is the limit state of the block 241. The transmission assembly includes a detection support plate 242, a rotating shaft 244, a rotating bushing 245, a block 241, a flip block 243, a roller 246, and a tension spring 247. The limit realization process of pushing the test strip 5 to the dripping position is as follows: the second power assembly drives the connecting plate 234 to move downward, and the connecting plate 234 drives the detection head 231 and the roller 246 to move downward synchronously. The flip block 243 is connected to one end of the tension spring 247, and at the same time, the flip block 243 is tightly attached to the roller 246 under the action of the tension spring 247, and the roller 246 is driven The dynamic flip block 243 rotates, thereby driving the rotating shaft 244 to rotate relative to the detection support plate 242, and driving the stopper 241 on the rotating shaft 244 to rotate. Under the action of the roller 246 and the flip block 243, the test paper stopper 241 remains in a vertical state and does not change, thereby blocking the test strip 5; when the test strip 5 is positioned, the second power component continues to act to move the detection head 231 downward by a certain distance, so that the contacts of the detection head 231 and the contacts of the test strip 5 can be in good contact and action, and the electrical signal after the whole blood drop sample is collected to obtain the glucose detection result of the blood sample.

[0089] like Fig.11 As shown, the block 241 is in the release state. When the test strip 5 completes the test, the second power assembly drives the connecting plate 234 upward, and the connecting plate 234 drives the detection head 231 and the roller 246 upward, and the detection head 231 leaves the surface of the test strip 5; the connecting plate 234 continues to move, and after the roller 246 moves upward for a certain displacement, the flip block 243 and the test paper block 241 rotate synchronously under the action of the tension spring 247, and rotate clockwise from the vertical state to the horizontal state, which is the release position state. At this time, the test strip 5 that has completed the test continues to move to the recovery box 251 under the action of the push assembly, and then the push assembly is reset to the vicinity of the strip selection mechanism 21, and then the first power assembly drives the connecting plate 234 downward to rotate the test paper block 241 to the limit state, preparing for the detection of the next sample.

[0090] During the test strip transportation process, the screw motor 232 drives the roller 246 to move vertically downward for a distance Z, so that the block 241 is in a limited state. After the test strip is transported here and positioned, the detection head 231Z located just above the detection position moves downward. There are two positions where the detection head 231 presses down and contacts the test strip 5. The middle one is used to assist in fixing the test strip 5, and the end is a common protruding metal pin. The setting of the metal pin corresponds one-to-one to the detection pin of the test strip 5. After the detection head 231 moves downward to the specified position, the reaction electrical signal of the test strip 5 can be collected. Similarly, the drive of the detection head 231 also adopts a flexible drive design, and the compression spring and the connecting block are used to ensure the stability of the contact between the detection head 231 and the test strip 5.

[0091] In some embodiments of the present invention, Figure 5 as well as Fig.12 As shown, the glucose detection module 2 includes a recovery module 25, and the recovery module 25 is used to collect the test strips 5 that have completed the test. The recovery module 25 includes a recovery box 251 arranged at the output end of the strip transport mechanism 22, and the recovery box 251 is used to receive and store the test strips 5 that have completed the test. The test strips 5 are tested and discarded, which avoids the problem of cleaning and can reduce the carryover contamination rate of sample glucose detection.

[0092] In some embodiments of the present invention, the recovery module 25 is arranged adjacent to the injection module 3 and close to the other side panel of the sample analyzer housing. A second side door is provided on the other side panel of the housing of the sample analyzer, and the operator can take out the full recovery box 251 and replenish the empty recovery box 251 through the second side door. With this solution, the operator can conveniently add sample tubes 7 to the injection module 3 when standing in front of the analyzer, and it is also convenient to replenish the spare recovery box 251 and take out the full recovery box 251 in the recovery module 25 through the second side door, thereby improving the convenience of operation.

[0093] In some embodiments of the present invention, Fig.12 As shown, the recycling module 25 also includes a conveying mechanism, which is provided with a working position and a box-returning buffer position, the working position is arranged at the output end of the strip transport mechanism 22, and the conveying mechanism is used to drive the recycling box 251 to move, so that the fully loaded recycling box 251 at the working position moves to the box-returning buffer position, so that the operator can take away the recycling box 251 filled with test strips 5 from the side of the analyzer.

[0094] In some embodiments of the present invention, a spare buffer position is further provided on the conveying mechanism, and the spare buffer position is used to place a spare recovery box 251, and the conveying mechanism is also used to drive the recovery box 251 on the spare buffer position to move to the working position.

[0095] In some embodiments of the present invention, Fig.12 As shown, the conveying mechanism includes a second carrying plate, a first conveying assembly, and a second conveying assembly. The second carrying plate is used to place the recovery box 251. The first conveying assembly includes a box-input push plate 2531 and a fourth drive assembly 2521. The box-input push plate 2531 is used to push the spare recovery box 251 on the second carrying plate to the working position, and the fourth drive assembly 2521 is used to drive the box-input push plate 2531 to move; the second conveying assembly includes a box-returning push plate 2532 and a fifth drive assembly 2522. The box-returning push plate 2532 is used to push the fully loaded recovery box 251 on the second carrying plate to the box-returning cache position, and the fifth drive assembly 2522 is used to drive the box-returning push plate 2532 to move.

[0096] In some embodiments of the present invention, the second carrier plate is in an L-shaped structure, so that the box ejection buffer position and the spare buffer position are relatively close to the injection module, thereby improving the convenience of operation.

[0097] In some embodiments of the present invention, the conveying mechanism further includes a first detection photoelectric device 2541, a second detection photoelectric device 2542 and a third detection photoelectric device 2543 respectively arranged at the box ejection buffer position, the working position and the standby buffer position.

[0098] The test paper recycling process is as follows: Fig.12As shown, the recovery box 251 located at the working position has a certain coordination relationship with the strip transport mechanism 22. The test strips 5 that have completed the test can be directly sent into the recovery box 251 through the push plate 221 in the strip transport mechanism 22. The control module counts the test strips 5 that have completed the test in real time. When the number of test strips 5 in the recovery box 251 reaches the set value, the control module issues a box-returning instruction to drive the fifth drive component 2522 to drive the box-returning push plate 2532 to move, and push the recovery box 251 at the working position to move to the box-returning cache position through the limit block 255 with a torsion spring. If the first detection photoelectric 2541 detects that there is a recovery box 251 on the box-returning cache position, the control module sends a prompt message through the human-computer interaction interface on the analyzer, prompting the operator to take it away from the side of the instrument. After the box-returning push plate 2532 is reset, the fourth driving assembly 2521 drives the box-entering push plate 2531 to transport and push the spare recovery box 251 to the working position. If the second detection photoelectric 2542 photoelectric detection detects that there is a recovery box 251 at the working position, the test strip 5 that has completed the test can be pushed out normally; then after the box-entering push plate 2531 is reset, the control module sends a prompt message through the human-computer interaction interface on the analyzer, prompting the operator to place the empty recovery box 251 in the spare cache position. If the third detection photoelectric 2543 detects the spare recovery box 251, the automatic box replacement after the next full material can be performed. The closed-loop control of the test paper recovery box 251 can be achieved by transporting and detecting the recovery box 251, ensuring its reliable automatic replacement and the collection of the test paper that has completed the test, and avoiding other risks such as downtime caused by manual replacement.

[0099] In some embodiments of the present invention, the sample analyzer further comprises a sampling module 3, and the sampling module 3 is used to transport the target sample tube 7 to the sampling position of the sampling distribution module 4. The sampling position, the reaction pool 11 and the dripping position of the glucose detection module 2 are sequentially located on the horizontal movement path of the sampling needle 41, and the horizontal movement path of the sampling needle 41 is a straight path.

[0100] In some embodiments of the present invention, the sampling distribution module 4 includes a sampling needle 41 and a moving mechanism, and the moving mechanism is used to drive the sampling needle 41 to move horizontally and vertically.

[0101] The blood samples include conventional samples and emergency samples, that is, the target sample tube 7 includes a conventional sample tube 7 and an emergency sample tube 7, and the sampling position includes a conventional sampling position and an emergency sampling position.

[0102] See also Figure 1 As shown, in some embodiments of the present invention, the sample introduction module 3 can transport the sample rack 6 carrying the conventional sample tube 7 along the first direction, and the first direction refers to the length direction of the sample rack 6, so as to transport the target sample tube 7 on the sample rack 6 to the conventional sampling position ( Figure 1 test tube rack sampling position in the test tube rack);

[0103] The paper strip supply mechanism is used to transfer the test strip 5 to the sample dropping position along the second direction; wherein the first direction is parallel to the second direction.

[0104] It can be understood that in order to transport the sample rack 6, the injection module is larger in the length direction (first direction) of the sample rack 6, while the paper strip supply mechanism is larger in the direction of transporting the test strip 5 (second direction). By arranging the large dimension direction of the injection module parallel to the large dimension direction of the paper strip supply mechanism, it is possible to avoid the injection module and the paper strip supply mechanism extending in different directions, thereby increasing the overall size of the sample analyzer.

[0105] In some embodiments of the present invention, the sampling needle 41 collects and distributes samples along a third direction. The third direction is at an angle to the first direction. In some embodiments of the present invention, the third direction is perpendicular to the first direction, which can make the path of the sampling needle 41 shorter, which is conducive to reducing the volume of the moving mechanism in the sampling and distribution module.

[0106] In some embodiments of the present invention, an emergency sample tube placement seat is provided on the injection module 3, and the injection module 3 transports the emergency sample tube on the placement seat to transport the target sample tube on the placement seat to the emergency sampling position.

[0107] In some embodiments of the present invention, Figure 4 and Figure 5 As shown, the projections of the reaction pool 11 and the injection module 3 on the horizontal plane overlap, making the instrument structure more compact and reducing the footprint of the instrument.

[0108] In some embodiments of the present invention, the glucose detection module 2 has a glucose selection mechanism 21, a glucose transport mechanism 22 and a recovery module arranged in sequence along the second direction.

[0109] In some embodiments of the present invention, the second direction is parallel to the first direction, so that the strip selection mechanism 21 and the recovery module are as close to the injection module as possible, thereby improving the operational convenience and making the instrument layout more compact.

[0110] In some embodiments of the present invention, Figure 1 and 5 As shown, the strip selection mechanism 21 is close to the right side of the instrument, and the recovery module 25 is close to the left side of the instrument. By exchanging their positions, the width of the analyzer can be narrower and the structure of the instrument can be more compact.

[0111] In some embodiments of the present invention, the reaction pool 11 and the sample dropping position of the glucose detection module 2 are located on the same side of the sample rack 6, and the reaction pool 11 is located between the sample dropping position of the glucose detection module 2 and the sample rack 6. After the sampling is completed from the sample tube 7 of the sample rack 6 by using the sampling distribution module, the sampling needle 41 can be controlled to move linearly to the reaction pool 11 to complete the sample distribution of the reaction pool 11, and then the sampling needle 41 is controlled to continue to move linearly along the direction to the sample dropping position of the glucose detection module 2 to complete the sample distribution of the sample at the sample dropping position of the glucose detection module 2.

[0112] In some embodiments of the present invention, the sample analyzer also includes a control module, which is communicatively connected with the injection module 3, the sampling and distribution module 4, the glycated hemoglobin detection module 1 and the glucose detection module 2. The control module is configured to control the injection module 3 to transport the target sample tube 7 to the sampling position of the sampling and distribution module 4, control the sampling and distribution module 4 to collect a blood sample from the target sample tube 7, and distribute the blood sample to the glycated hemoglobin detection module 1 and the glucose detection module 2, and control the glycated hemoglobin detection module 1 and the glucose detection module 2 to complete the detection of the distributed blood sample.

[0113] In some embodiments of the present invention, after the control module controls the sampling and distributing module 4 to collect the blood sample from the target sample tube 7, the control module controls the sampling and distributing module 4 to first distribute the sample to the reaction pool 11 in the glycated hemoglobin detection module 1, and then distributes the sample to the test strip 5 of the glucose detection module 2. The glycated hemoglobin detection with a long detection time is started first, thereby improving the detection speed.

[0114] That is to say, the time required for glycated hemoglobin detection is longer, and generally speaking, the difference between the first time and the second time is larger. The sample is first allocated to the glycated hemoglobin detection module 1 which takes longer time. During the process of the glycated hemoglobin detection module 1 performing sample detection, the sampling allocation module can be controlled to allocate the sample to the sample drop position of the glucose detection module 2, and the glucose detection module 2 allocated with the sample can be controlled to complete the relevant detection process, so as to achieve the effect of shortening the detection time.

[0115] In some embodiments of the present invention, the control module is configured to control the glucose detection module 2 to complete the sample pre-test preparation work before or at the same time as controlling the sampling distribution module to distribute the sample to the reaction pool 11 of the glycated detection module, wherein the preparation work includes moving the test paper to the sample drop position and electrically connecting the second detector to the test paper. That is to say, for the sample detection in the same sample tube 7, the control module will first control the glucose detection module 2 to complete the sample pre-test preparation work before completing the sample distribution of the reaction pool 11, so that after distributing the sample to the reaction pool 11, the sample can be directly distributed to the test strip 5 that has completed the sample pre-test preparation work, thereby shortening the sample distribution time. Among them, the glucose detection module 2 can be controlled to complete the sample pre-test preparation work during the process of the glycated hemoglobin detection module 1 detecting or cleaning the sample in the previous sample tube 7. The glucose detection module 2 can also be controlled to complete the sample pre-test preparation work during the process of the glycated hemoglobin detection module 1 distributing the sample, as long as the sample pre-test preparation work of the glucose detection module 2 is completed before the sample distribution of the glycated hemoglobin detection module 1 is completed.

[0116] In the above scheme, the control module is configured to control the sampling distribution module to first distribute the sample to the reaction pool 11 in the glycated hemoglobin detection module and then distribute the sample to the sample dripping position of the glucose detection module 2 after the sampling distribution module collects the blood sample from the target sample tube, and the control module is configured to control the glucose detection module 2 to complete the preparatory work before or at the same time as the sampling distribution module distributes the sample to the reaction pool 11 of the glycated detection module, wherein the preparatory work includes moving the test paper to the sample dripping position and electrically connecting the second detector to the test paper. By adopting this scheme, it is possible to avoid reducing the detection throughput of the instrument due to increasing the blood glucose detection of the sample, so that the detection throughput of the instrument depends on the glycated hemoglobin detection time of the sample, and the glycated hemoglobin and blood glucose joint detection flux of the instrument is the same as the detection flux of glycated hemoglobin alone, thereby improving the glycated hemoglobin and blood glucose joint detection flux of the instrument.

[0117] In some embodiments of the present invention, the time required for the glycated hemoglobin detection module 1 to complete the detection of a blood sample is the first time, and the time required for the glucose detection module 2 to complete the detection of a blood sample is the second time, and the second time is less than the first time. When the glucose detection module 2 completes the detection of sample 1 and the glycated hemoglobin detection module 1 has not completed the detection of sample 1, the control module controls the glucose detection module 2 to perform the preparation work such as selecting and moving the strips and pressing down the detection head 231 required for the detection of sample 2.

[0118] In some embodiments of the present invention, the amount of the blood sample for glucose detection is 0.3-3ul, preferably 0.5-1ul; the amount of the blood sample for glycated hemoglobin detection is 3-8ul.

[0119] In some embodiments of the present invention, Figure 2 As shown, the glycated hemoglobin detection module 1 also includes an eluent supply component 14, a hemolytic agent supply component, and an injection valve 15. The eluent supply component 14 can provide eluents with different composition ratios, and can bring the quantitative sample liquid to be tested in the quantitative ring 151 of the injection valve 15 into the chromatographic column 13 through the eluent for gradient elution to separate the components in the sample liquid to be tested. The first detector 12 is used to detect the separated components, and after detecting the absorbance of each component, a chromatogram is formed through data processing to obtain the parameters of glycated hemoglobin. The eluent supply component 14 includes an eluent A storage bottle 141, an eluent B storage bottle 142, a degasser 143, a proportional valve 144, a high-pressure pump 145, and a damper 146; the hemolytic agent supply component is used to supply the hemolytic agent to the reaction pool 11 to dilute and hemolyze the blood sample to release the hemoglobin in the blood sample.

[0120] After the test strip 5 completes all pre-test actions, the control module can control the movement of the sampling distribution module 4, control the sampling needle 41 tip to drop the sample at a height of 0.2-0.5mm from the test paper drop position, and push out about 0.3-3ul of sample. The sample reacts chemically with the enzyme on the test strip 5 to generate an electrical signal, which can be analyzed to obtain the blood glucose concentration test value of the sample. After the sample is dropped, the sampling needle 41 returns to the reset position, and the injection pump pushes about hemolytic agent along the inner wall of the sampling needle 41 to flush it. The negative pressure generated by the swab absorbs the cleaning waste liquid, so that the sampling needle 41 meets the sample carryover contamination rate requirements, ensuring the accuracy of the next sample detection value.

[0121] In some embodiments of the present invention, the control module is configured to control the test strip supply mechanism to supply the test strip 5 to the sample dripping position with the front side facing up, control the second detector to drive the detection head 231 close to the test strip 5, and make the detection head 231 electrically connected to the contact area 52 of the test strip 5, control the sampling and distribution module to absorb the blood sample in the target sample tube 7 once, and distribute it to the sample dripping area 51 of the test strip 5 to obtain the glucose parameter; control the sampling and distribution module to distribute the blood sample absorbed once to the reaction pool 11, control the hemolytic agent supply component to supply hemolytic agent to the reaction pool 11 to dilute the hemolyzed blood sample to prepare a sample liquid to be tested, control the chromatographic column 13 to separate the components in the sample liquid to be tested, and the first detector 12 to detect the separated components to obtain the glycated hemoglobin parameter of the blood sample. It should be noted that the side of the test strip 5 where the sample dripping area 51 and the contact area 52 are located is the front side.

[0122] In the description of the present invention, the terms "first", "second", etc. are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0123] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of this specification. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art may combine and combine the different embodiments or examples described in this specification and the features of the different embodiments or examples, unless they are contradictory.

[0124] Although the embodiments of the present invention have been shown and described above, it is to be understood that the above embodiments are exemplary and are not to be construed as limitations of the present invention. A person skilled in the art may change, modify, replace and vary the above embodiments within the scope of the present invention.

Claims

1. A sample analyzer, characterized in that: It includes: Sampling distribution module, glycosylated hemoglobin detection module and glucose detection module; The sampling distribution module is used to obtain a blood sample from a target sample tube and distribute the blood sample to the glycated blood glucose protein detection module and the glucose detection module; The glycated hemoglobin detection module comprises a reaction pool, a chromatographic column and a first detector, wherein the reaction pool is used for a blood sample to react with a reagent to form a sample solution to be tested, the chromatographic column is used for separating components in the sample solution to be tested, and the first detector is used for detecting the separated components to obtain the glycated hemoglobin parameter of the blood sample; The glucose detection module includes a test strip supply mechanism and a second detector. The test strip supply mechanism is used to supply test strips to a sample dropping position. The test strips at the sample dropping position are used to receive blood samples. The second detector is used to be electrically connected to the test strips at the sample dropping position to detect and obtain glucose parameters of the blood sample.

2. The sample analyzer according to claim 1, characterized in that: The test strip supply mechanism comprises a test strip storage container and a test strip transfer mechanism. The test strip storage container is used to store test strips, and the test strip transfer mechanism is used to transfer the test strips in the test strip storage container to the sample dropping position one by one.

3. The sample analyzer according to claim 2, characterized in that: The test strip transfer mechanism includes any one of a gripper, a suction cup or a pusher.

4. The sample analyzer according to claim 2, characterized in that: The test strip supply mechanism includes a strip selection mechanism and a strip transport mechanism; The strip selection mechanism is used to store the test strips and output the test strips one by one to the strip transport mechanism; The strip transport mechanism is used to transport the test strip output by the strip selection mechanism to the sample dropping position; The sampling distribution module is configured to distribute a portion of the blood sample to the test strip located at the sample dropping position.

5. The sample analyzer according to claim 4, characterized in that: The strip selection mechanism includes a shell and a rotating roller, the top of the shell is provided with a receiving groove, the rotating roller is arranged inside the shell, and the rotating roller is located below the receiving groove, the circumferential surface of the rotating roller is provided with a groove, and the groove can only accommodate one test strip, and the rotating roller rotates to bring the test strip that falls into the groove from the receiving groove out of the shell, so as to output the test strip to the strip transport mechanism.

6. The sample analyzer according to claim 4, characterized in that: The strip transport mechanism includes a pushing component and a first carrying plate. The first carrying plate is used for carrying the test strip, and the pushing assembly is used for pushing the test strip to move on the first carrying plate.

7. The sample analyzer according to claim 1, characterized in that: The second detector comprises a detection head and a second driving assembly, and the second driving assembly is used to drive the detection head to move so that the detection head is electrically connected to the test paper strip at the sample dropping position.

8. The sample analyzer according to claim 1, characterized in that: The glucose detection module further comprises a blocking mechanism, and the blocking mechanism is used to cooperate with the test strip supply mechanism to position the test strip at the sample dropping position.

9. The sample analyzer according to claim 8, characterized in that: The blocking mechanism includes a block and a third driving assembly, wherein the third driving assembly is used to drive the block to block the test strip from continuing to move, and the third driving assembly includes a second power assembly and a transmission assembly, wherein the second power assembly drives the block to move via the transmission assembly.

10. The sample analyzer according to claim 9, characterized in that: The second detector includes a detection head and a second drive assembly, the second drive assembly includes a first power assembly, the first power assembly is used to drive the detection head to move so that the detection head is electrically connected to the test strip, and the second power assembly is the same power assembly as the first power assembly.

11. The sample analyzer according to claim 9, characterized in that: The transmission assembly includes a detection support plate, a flip block and a rotating shaft. The detection support plate is rotatably connected to the rotating shaft. The flip block and the stop block are both connected to the rotating shaft. The second power assembly is used to drive the flip block to rotate, thereby driving the stop block to rotate to limit the test strip.

12. The sample analyzer according to claim 11, characterized in that: The transmission assembly also includes a roller, which is installed on the second power assembly and fits the flip block. The second power assembly drives the roller to move in a direction perpendicular to the rotating shaft to drive the flip block to rotate.

13. The sample analyzer according to claim 11, characterized in that: The flip block is connected with a tension spring, and the tension spring is used to drive the flip block to reset.

14. The sample analyzer according to claim 1, characterized in that: The glucose detection module further includes a recovery module, which includes a recovery box arranged at the output end of the test strip supply mechanism, and the recovery box is used to receive and store the test strips that have completed the test.

15. The sample analyzer according to claim 14, characterized in that: The recycling module also includes a conveying mechanism, which is provided with a working position and a box-returning cache position. The working position is arranged at the output end of the test strip supply mechanism. The conveying mechanism is used to drive the recycling box to move, so that the fully loaded recycling box at the working position moves to the box-returning cache position.

16. The sample analyzer according to claim 14, characterized in that: The recycling module also includes a conveying mechanism, which is provided with a working position and a spare buffer position. The spare buffer position is used to place a spare recycling box, and the conveying mechanism is also used to drive the recycling box on the spare buffer position to move to the working position.

17. The sample analyzer according to claim 1, characterized in that: It also includes an injection module, which is used to transport the target sample tube to the sampling position of the sampling distribution module. The sampling position, the reaction pool and the dripping position of the glucose detection module are located in sequence on the horizontal movement path of the sampling needle, and the horizontal movement path of the sampling needle is a straight path.

18. The sample analyzer according to claim 17, characterized in that: The sample introduction module is capable of transporting a sample rack carrying conventional sample tubes along a first direction, wherein the first direction is the length direction of the sample rack; The paper strip supply mechanism is used to transfer the test strip to the sample dropping position along a second direction, wherein the first direction is parallel to the second direction.

19. The sample analyzer according to claim 17, characterized in that: The projections of the reaction pool and the injection module on the horizontal plane overlap.

20. The sample analyzer according to claim 1, characterized in that: It also includes a control module, which is communicatively connected with the sampling and distribution module, the glycated hemoglobin detection module and the glucose detection module. The control module is configured to control the sampling and distribution module to first distribute the sample to the reaction pool in the glycated hemoglobin detection module and then distribute the sample to the dripping position of the glucose detection module after collecting the blood sample from the target sample tube.

21. The sample analyzer according to claim 20, characterized in that: The control module is configured to control the glucose detection module to complete the sample detection preparation work before or while controlling the sampling distribution module to distribute the sample to the reaction pool of the saccharification detection module, wherein the preparation work includes moving the test paper to the sample dropping position and electrically connecting the second detector to the test paper.

22. The sample analyzer according to claim 1, characterized in that: The blood sample volume for glucose detection is 0.3-3ul, and the blood sample volume for glycosylated hemoglobin detection is 3-8ul.

23. The sample analyzer according to claim 1, characterized in that: The glycated hemoglobin detection module also includes an eluent supply component, a hemolytic agent supply component, and an injection valve. The eluent supply component can provide eluents with different composition ratios, and can bring the quantitatively quantified sample liquid in the quantitative loop of the injection valve into the chromatographic column through the eluent for gradient elution to separate the components in the sample liquid to be tested. The first detector is used to detect the separated components, and after detecting the absorbance of each component, a chromatogram is formed through data processing to obtain the parameters of glycated hemoglobin.

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