Sample collecting device for PCR (Polymerase Chain Reaction) detection

Abstract

The invention relates to the technical field of medical instruments, in particular to a sample collecting device for PCR detection, which comprises a sampling tube, a sampling mechanism and a protective cover, the sampling tube comprises a tube body, and the bottom of the tube body is provided with an opening; the sampling mechanism comprises a sampling rod, the sampling rod is located in the pipe body, sampling cotton is arranged at the end of the sampling rod, a driving handle is fixedly connected to the upper end of the sampling rod, the pipe body is sleeved with the driving handle, and the driving handle is in threaded fit with the pipe body. The protective cover comprises a shell, the shell is arranged at the bottom of the pipe body in a sleeving mode, and a protective opening is formed in the bottom of the shell. The protective cover further comprises a sliding plate, the sliding plate can horizontally slide in the shell, and a connecting piece is arranged between the sliding plate and the pipe body. A driving plate is rotationally arranged on the driving handle and can be inserted into the shell and drive the sliding plate to move in the horizontal direction, the protective opening is opened while the oral cavity of the human body is opened, meanwhile, the connecting piece can be cut off, and separation of the protective cover and the sampling tube is achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a sample collection device for PCR detection. Background Art

[0002] PCR testing is a medical testing method. A small amount of secretions is taken from the human throat with a medical cotton swab, inoculated into a special culture dish, and then placed in a temperature-controlled device for culture. This can be used to understand the patient's condition, oral mucosa and pharyngeal infection.

[0003] Existing conventional PCR sampling usually requires medical staff to use cotton swabs to obtain the sample to be tested, then open the test tube, and finally seal the sample to be tested in the test tube. During the entire sampling process, medical staff can easily come into contact with the inside of the patient's mouth, which can easily cause cross-infection. The entire sampling process is cumbersome, and the sample obtained from the cotton swab may come into contact with pollutants exposed in the air, which is not conducive to ensuring the accuracy of the test results. Summary of the invention

[0004] Based on this, it is necessary to provide a sample collection device for PCR detection to address the technical problem that current PCR sampling is prone to cross-infection, thereby affecting detection accuracy.

[0005] The above purpose is achieved through the following technical solutions: A sample collection device for PCR detection comprises a sampling tube, a sampling mechanism and a protective cover, wherein the sampling tube comprises a tube body, and an opening is provided at the bottom of the tube body; The sampling mechanism comprises a sampling rod, the sampling rod is located inside the tube body, a sampling cotton is arranged at the end of the sampling rod, the upper end of the sampling rod is fixedly connected with a driving handle, the driving handle is sleeved outside the tube body and matched with the tube body thread, and the driving handle can be moved downward along the tube body by rotating the driving handle, thereby driving the sampling rod to extend from the opening; The protective cover comprises a shell, the shell is sleeved on the bottom of the tube body, the bottom of the shell is provided with a protective opening, the protective opening corresponds to the opening, the protective cover also comprises a sliding plate, the sliding plate can slide horizontally in the shell, and a connecting piece is provided between the sliding plate and the tube body; In the initial state, the sliding plate blocks the protective opening; a driving plate is rotatably provided on the driving handle, and the driving plate can be inserted into the outer shell and drive the sliding plate to move in the horizontal direction, thereby opening the human oral cavity and the protective opening at the same time. At this time, the driving plate can also cut off the connecting piece to separate the protective cover from the sampling tube.

[0006] Furthermore, the bottom of the driving plate is a driving inclined surface, and the driving inclined surface is inclined from the outside of the tube body to the inside of the tube body from top to bottom.

[0007] Furthermore, a cutting edge is provided on the outer side surface of the driving plate, and in the up-down direction, the bottom end of the cutting edge is higher than the bottom end of the driving inclined surface and lower than the top end of the driving inclined surface.

[0008] Furthermore, the driving plates are provided in plurality, the housing is provided with vertical insertion slots, the vertical insertion slots correspond to the driving plates one by one, and the housing is further provided with horizontal slots, the horizontal slots are connected to the vertical insertion slots.

[0009] Furthermore, the sliding plate includes a vertical section and a horizontal section, the vertical section is located in the horizontal groove, and the horizontal section is used to cover the protective opening. When the driving plate is inserted into the vertical insertion groove from top to bottom, the driving inclined surface will push the sliding plate to slide outward along the horizontal groove.

[0010] Furthermore, the connecting member is an elastic rope, one end of the elastic rope extends into the horizontal groove and is connected to the vertical section, and the other end of the elastic rope is connected to the outer side surface of the tube body.

[0011] Furthermore, a storage cavity is provided in the vertical section, the elastic rope is a hollow structure, the interior of the elastic rope is connected to the storage cavity, and a virus preservation liquid is placed in the storage cavity.

[0012] Furthermore, a transfer cavity is provided on the driving plate, and a connecting port is provided on the tube body. The left side of the transfer cavity can be connected with the storage cavity, and the right side of the transfer cavity can be connected with the connecting port.

[0013] Furthermore, a water-isolating ring is provided around the opening.

[0014] Furthermore, the upper end of the tube body is provided with an external thread, the driving handle is provided with an internal thread, and the tube body is provided with a plurality of through holes, which are used to guide the driving plate to move up and down, and the through holes correspond to the vertical insertion slots.

[0015] The beneficial effects of the present invention are: The sample collection device for PCR detection provided by the present invention, when in use, the driving handle is rotated forward to move the driving plate downward along the tube body, the driving handle can drive the sampling rod to extend from the opening of the tube body, and at the same time, the driving plate on the driving handle can be inserted into the outer shell of the protective cover, and the driving sliding plate is driven to slide outward in the horizontal direction, so that the protective opening of the protective cover is opened, and at the same time, the sliding plate slides outward to open the human mouth to facilitate sampling by the sampling rod. In addition, the downward movement of the driving plate can cut off the connecting piece, so that the protective cover is separated from the sampling tube. In this way, after the sampling is completed, the protective cover remains in the human mouth, and the sampling rod can be retracted into the tube body by rotating the driving handle in the opposite direction, so that the sampling rod will not be contaminated by the outside air, and medical staff does not need to touch the human mouth, thereby improving the accuracy of subsequent detection results.

[0016] Secondly, after the driving plate of the present application cuts off the elastic rope, the virus preservation liquid in the storage chamber of the sliding plate will flow into the transfer chamber on the driving plate. After the driving plate is moved up and reset, the transfer chamber can be connected with the connecting port on the tube body, so that the virus preservation liquid will flow into the tube body to process the sample in the tube body. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 A schematic diagram of the three-dimensional structure of a sample collection device for PCR detection provided by an embodiment of the present invention; Figure 2 for Figure 1 Bottom view of Figure 3 for Figure 2 Middle AA section view; Figure 4 A working state diagram of a sample collection device for PCR detection provided by an embodiment of the present invention; Figure 5 for Figure 4 Bottom view of Figure 6 for Figure 5 Middle BB section view; Figure 7 A schematic diagram of the structure of a sample collection device for PCR detection provided by one embodiment of the present invention; Figure 8 A schematic diagram of the structure of a sample collection device for PCR detection provided by one embodiment of the present invention; Fig. 9 This is a schematic diagram of the structure of a sample collection device for PCR detection provided by one embodiment of the present invention.

[0018] in: 100. Sampling mechanism; 101. Driving handle; 102. Driving plate; 103. Driving ramp; 104. Cutting blade; 105. Transfer chamber; 106. Sampling rod; 200. Sampling tube; 201. Tube body; 202. Connecting port; 203. Waterproof ring; 204. Through hole; 300. Protective cover; 301. Housing; 302. Sliding plate; 303. Storage chamber; 304. Elastic rope; 305. Protective port; 306. Vertical insertion slot. DETAILED DESCRIPTION

[0019] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below through embodiments and in conjunction with the accompanying drawings. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0020] The serial numbers assigned to the components herein, such as "first", "second", etc., are only used to distinguish the objects described and do not have any order or technical meaning. The "connection" and "coupling" mentioned in this application, unless otherwise specified, include direct and indirect connections (couplings). In the description of the present invention, it should be understood that the orientation or position relationship indicated by the terms "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", etc. are based on the orientation or position relationship shown in the accompanying drawings, which is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation to the present invention.

[0021] In the present invention, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may mean that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediate medium. Moreover, a first feature being "above", "above" or "above" a second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. A first feature being "below", "below" or "below" a second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0022] like Figures 1 to 9 As shown, a sample collection device for PCR detection provided by an embodiment of the present invention includes a sampling tube 200, a sampling mechanism 100 and a protective cover 300. The sampling tube 200 includes a tube body 201, and an opening is provided at the bottom of the tube body 201.

[0023] The sampling mechanism 100 includes a sampling rod 106, which is located inside the tube body 201. A sampling cotton is provided at the end of the sampling rod 106. The upper end of the sampling rod 106 is fixedly connected to a driving handle 101. The driving handle 101 is sleeved on the outside of the tube body 201 and threadedly matched with the tube body 201. By rotating the driving handle 101, the driving handle 101 can be moved downward along the tube body 201, thereby driving the sampling rod 106 to extend out of the opening.

[0024] The protective cover 300 includes a shell 301, which is sleeved on the bottom of the tube body 201. The bottom of the shell 301 is provided with a protective opening 305, and the protective opening 305 corresponds to the opening. The protective cover 300 also includes a sliding plate 302, which can slide horizontally in the shell 301, and a connecting piece is provided between the sliding plate 302 and the tube body 201.

[0025] In the initial state, the sliding plate 302 covers the protective opening 305; a driving plate 102 is rotatably provided on the driving handle 101, and the driving plate 102 can be inserted into the shell 301 and drive the sliding plate 302 to move in the horizontal direction, thereby stretching the human oral cavity and opening the protective opening 305 at the same time. At this time, the driving plate 102 can also cut off the connecting piece to separate the protective cover 300 from the sampling tube 200.

[0026] In one embodiment, the bottom of the driving plate 102 is a driving inclined surface 103, and the driving inclined surface 103 is inclined from the outside of the tube body 201 to the inside of the tube body 201 from top to bottom. In other embodiments, a wedge block is fixedly installed at the bottom of the driving plate 102.

[0027] In one embodiment, a cutting blade 104 is provided on the outer side of the driving plate 102. In the up-down direction, the bottom end of the cutting blade 104 is higher than the bottom end of the driving inclined surface 103 and lower than the top end of the driving inclined surface 103. When the driving plate 102 moves downward, the horizontal sliding of the sliding plate 302 is realized first, and then the cutting of the connecting piece is realized. In this embodiment, the cutting blade 104 is integrally formed with the driving plate 102, so as to facilitate processing. In other embodiments, the cutting blade 104 can be set as a metal blade, which is fixedly set on the driving plate 102.

[0028] In one embodiment, the driving plate 102 is provided with a plurality of vertical insertion slots 306, the housing 301 is provided with a vertical insertion slot 306, the vertical insertion slot 306 corresponds to the driving plate 102 one by one, and the housing 301 is also provided with a horizontal slot, the horizontal slot is connected to the vertical insertion slot 306. In this embodiment, the driving plate 102 is provided with four and is evenly distributed along the circumference of the driving handle 101, the housing 301 is provided with four vertical insertion slots 306, and the horizontal cross-sections of the driving plate 102 and the vertical insertion slot 306 are both arc-shaped. In other embodiments, the driving plate 102 and the vertical insertion slot 306 can be provided with two, six or eight, as long as they are provided in pairs.

[0029] In one embodiment, the sliding plate 302 includes a vertical section and a horizontal section, the vertical section is located in the horizontal groove, and the horizontal section is used to cover the protective opening 305. When the driving plate 102 is inserted into the vertical insertion groove 306 from top to bottom, the driving inclined surface 103 will push the vertical section of the sliding plate 302 to slide outward along the horizontal groove, driving the sliding plate 302 to slide outward as a whole. The number of the sliding plates 302 corresponds to the number of the driving plates 102. In this embodiment, four sliding plates 302 are provided, and the horizontal section of each sliding plate 302 is provided with a fan-shaped portion, and the curvature of the fan-shaped portion is 90 degrees. In other embodiments, the sliding plates 302 can be set to two, six or eight, and the curvature of the fan-shaped portion is adaptively adjusted.

[0030] In one embodiment, the connecting member is an elastic rope 304 , one end of the elastic rope 304 extends into the horizontal groove and is connected to the vertical section, and the other end of the elastic rope 304 is connected to the outer side surface of the tube body 201 .

[0031] In one embodiment, a storage cavity 303 is provided in the vertical section, the elastic rope 304 is a hollow structure, the interior of the elastic rope 304 is connected to the storage cavity 303, and a virus preservation solution is placed in the storage cavity 303. In other embodiments, the connector is a retractable tube, such as a corrugated tube.

[0032] In one embodiment, the driving plate 102 is provided with a transfer chamber 105, and the tube body 201 is provided with a communication port 202, the left side of the transfer chamber 105 can be communicated with the storage chamber, and the right side of the transfer chamber 105 can be communicated with the communication port 202. The communication port 202 is inclined from outside to inside, so as to facilitate the virus preservation liquid to flow to the tube body 201.

[0033] In one embodiment, a water-isolating ring 203 is provided around the opening, and the water-isolating ring 203 has a certain height to prevent the virus preservation solution from flowing out of the opening. In this embodiment, a sealing plug is also provided on the opening, and the opening is finally sealed to facilitate the transfer of the sampling tube 200.

[0034] In one embodiment, the upper end of the tube body 201 is provided with an external thread, the driving handle 101 is provided with an internal thread, and the tube body 201 is provided with a plurality of through holes 204, which are used to guide the driving plate 102 to move up and down, and the through holes 204 correspond to the vertical insertion slots 306. The through holes 204 are arc-shaped holes, and the through holes 204 enable the driving plate 102 to be smoothly inserted into the vertical insertion slots 306 of the protective cover 300.

[0035] In combination with the above embodiments, the use principle and working process of the sample collection device for PCR detection in the embodiment of the present invention are as follows: When in use, the driving handle 101 is first rotated forward to move the driving plate 102 downward along the through hole 204 of the tube body 201. The driving handle 101 drives the sampling rod 106 to extend from the opening of the tube body 201, and the driving plate 102 can be inserted into the vertical insertion groove 306 of the protective cover 300. Then, the driving inclined surface 103 at the bottom of the driving plate 102 drives the sliding plate 302 to slide outward along the horizontal groove, so that the protective opening 305 of the protective cover 300 is opened, and multiple sliding plates 302 slide outward at the same time. The kinetic energy will open the oral cavity of the human body, so that the sampling rod 106 can take samples. At this time, the sliding plate 302 moves outward to pull the elastic rope 304, so that the elastic rope 304 is tightened. As the driving plate 102 continues to move downward, the cutting blade 104 on the outer side of the driving plate 102 will contact the elastic rope 304 to cut off the elastic rope 304, so that the sliding plate 302 is separated from the tube body 201, that is, the protective cover 300 is separated from the sampling tube 200, so that after the sampling is completed, the protective cover 300 will remain in the oral cavity of the human body. Finally, the driving handle 101 is rotated in the opposite direction to move the driving plate 102 upward, and the sampling rod 106 is moved upward and retracted into the tube body 201, so that the sampling rod 106 will not be contaminated by the outside air, and the medical staff does not need to touch the oral cavity of the human body, thereby improving the accuracy of the subsequent test results.

[0036] When the cutting blade 104 on the driving plate 102 cuts the elastic rope 304, the virus preservation liquid in the storage chamber of the sliding plate 302 will flow into the transfer chamber 105 of the driving plate 102. After the driving plate 102 moves up, the transfer chamber 105 can be connected with the connecting port 202 on the tube body 201, so that the virus preservation liquid will flow into the tube body 201. Due to the provision of the water-isolating ring 203, the virus preservation liquid will not flow out of the opening, thereby realizing the preservation of the sample in the tube body 201. Finally, the opening is closed by the closing plug to transfer the sampling tube 200.

[0037] The technical features of the above embodiments may be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0038] The above-described embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the present invention. It should be pointed out that, for a person of ordinary skill in the art, several modifications and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the attached claims.

Claims

1. A sample collection device for PCR detection, characterized in that: It includes a sampling tube, a sampling mechanism and a protective cover, wherein the sampling tube includes a tube body, and an opening is provided at the bottom of the tube body; The sampling mechanism comprises a sampling rod, the sampling rod is located inside the tube body, a sampling cotton is arranged at the end of the sampling rod, the upper end of the sampling rod is fixedly connected with a driving handle, the driving handle is sleeved outside the tube body and matched with the tube body thread, and the driving handle can be moved downward along the tube body by rotating the driving handle, thereby driving the sampling rod to extend from the opening; The protective cover comprises a shell, the shell is sleeved on the bottom of the tube body, the bottom of the shell is provided with a protective opening, the protective opening corresponds to the opening, the protective cover also comprises a sliding plate, the sliding plate can slide horizontally in the shell, and a connecting piece is provided between the sliding plate and the tube body; In the initial state, the sliding plate blocks the protective opening; a driving plate is rotatably provided on the driving handle, and the driving plate can be inserted into the outer shell and drive the sliding plate to move in the horizontal direction, thereby opening the human oral cavity and the protective opening at the same time. At this time, the driving plate can also cut off the connecting piece to separate the protective cover from the sampling tube.

2. The sample collection device for PCR detection according to claim 1, characterized in that: The bottom of the driving plate is a driving inclined surface, and the driving inclined surface is inclined from the outside of the tube body to the inside of the tube body from top to bottom.

3. The sample collection device for PCR detection according to claim 2, characterized in that: A cutting edge is provided on the outer side surface of the driving plate. In the up-down direction, the bottom end of the cutting edge is higher than the bottom end of the driving inclined surface and lower than the top end of the driving inclined surface.

4. The sample collection device for PCR detection according to claim 2, characterized in that: There are multiple drive plates, the shell is provided with vertical insertion slots, the vertical insertion slots correspond to the drive plates one by one, and the shell is also provided with horizontal slots, which are connected with the vertical insertion slots.

5. The sample collection device for PCR detection according to claim 4, characterized in that: The sliding plate includes a vertical section and a horizontal section, the vertical section is located in the horizontal groove, and the horizontal section is used to cover the protective opening. When the driving plate is inserted into the vertical insertion groove from top to bottom, the driving inclined surface will push the sliding plate to slide outward along the horizontal groove.

6. The sample collection device for PCR detection according to claim 5, characterized in that: The connecting piece is an elastic rope, one end of which extends into the horizontal groove and is connected to the vertical section, and the other end of the elastic rope is connected to the outer side surface of the tube body.

7. The sample collection device for PCR detection according to claim 6, characterized in that: A storage cavity is arranged in the vertical section, the elastic rope is a hollow structure, the interior of the elastic rope is communicated with the storage cavity, and virus preservation liquid is placed in the storage cavity.

8. The sample collection device for PCR detection according to claim 7, characterized in that: The driving plate is provided with a transfer cavity, the tube body is provided with a communication port, the left side of the transfer cavity can be communicated with the storage cavity, and the right side of the transfer cavity can be communicated with the communication port.

9. The sample collection device for PCR detection according to claim 1, characterized in that: A water-isolating ring is arranged around the opening.

10. The sample collection device for PCR detection according to claim 4, characterized in that: The upper end of the tube body is provided with an external thread, the driving handle is provided with an internal thread, and the tube body is provided with a plurality of through holes, which are used to guide the driving plate to move up and down, and the through holes correspond to the vertical insertion slots.

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