Oil-soluble composition of phytosphingosine as well as preparation method and application of oil-soluble composition

Abstract

The invention discloses an oil soluble composition of phytosphingosine, which is prepared from phytosphingosine, 1, 2-hexanediol, dipropylene glycol and octyldodecanol, in the oil-soluble composition, the mass ratio of phytosphingosine to 1, 2-hexanediol to dipropylene glycol to octyldodecanol is 1: A: B: C, and A, B and C meet the following conditions: A is more than or equal to 4 and less than or equal to 96, B is more than or equal to 4 and less than or equal to 96, C is more than or equal to 0 and less than or equal to 250, A + B + C is more than or equal to 28, and A + B is more than or equal to 14. The invention further discloses a preparation method and application of the oil-soluble composition of the phytosphingosine and a cosmetic containing the oil-soluble composition of the phytosphingosine. The oil-soluble composition of the phytosphingosine disclosed by the invention is a clear and transparent oil solution, so that the phytosphingosine can be conveniently used in various cosmetic product formulas, pure transparent oil products can be prepared, and the application prospect of the phytosphingosine is expanded; the preparation process of the oil-soluble composition is simple, the application difficulty of phytosphingosine is greatly reduced, and the application cost of factories and consumers can be reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to an oil-soluble composition of phytosphingosine and a preparation method and application thereof. Background Art

[0002] Phytosphingosine is an octadecyl amino alcohol containing an unsaturated hydrocarbon chain. Figure 1 As shown. Phytosphingosine is one of the components of cell membranes and is also a lipid signaling molecule that participates in a variety of cellular processes. At the same time, phytosphingosine is a lipid naturally produced by the skin that has the function of inhibiting microorganisms, and plays an important role in regulating the skin's microecology. Related studies have found that phytosphingosine has high inhibitory activity against a variety of harmful bacteria, such as Staphylococcus aureus, Propionibacterium acnes, Malassezia, etc. These microorganisms are closely related to atopic dermatitis, acne, seborrheic dermatitis and other problems. Phytosphingosine has a very high application value in cosmetics and its market price is relatively high. However, its molecular structure contains fatty chains and hydroxyl groups, which make it neither completely soluble in water nor completely soluble in oil. It is difficult to apply in formulations, and its dosage is also subject to certain restrictions.

[0003] With the development of synthetic biology, the industrialization of phytosphingosine has made great progress, and the market price has also dropped significantly. However, due to its high difficulty in application, when it was used in actual cosmetic formulas in the past, it needed to be made into a water-soluble package through a special process, which was not cost-effective and the dosage was limited, which restricted its application in different product dosage forms, such as transparent essence oil system or transparent aqueous system. Summary of the invention

[0004] The technical problem to be solved by the present invention is to provide an oil-soluble composition of phytosphingosine, which is a clear and transparent oil solution, which not only facilitates the use of phytosphingosine in various cosmetic product formulas, but also can prepare pure and transparent oil products, thereby expanding the application prospects of phytosphingosine; the preparation process of the oil-soluble composition is simple, which greatly reduces the application difficulty of phytosphingosine and is conducive to reducing the application costs of factories and consumers.

[0005] In order to solve the above technical problems, the present invention provides the following technical solutions: A first aspect of the present invention provides an oil-soluble composition of phytosphingosine, comprising phytosphingosine, 1,2-hexanediol, dipropylene glycol and octyldodecanol; in the oil-soluble composition, the mass ratio of phytosphingosine, 1,2-hexanediol, dipropylene glycol and octyldodecanol is 1:A:B:C, wherein A, B and C satisfy: 4≤A≤96, 4≤B≤96, 0≤C≤250, and A+B+C≥28, A+B≥14.

[0006] The molecular structure of phytosphingosine contains fatty chains and hydroxyl groups, which makes it neither completely soluble in water nor completely soluble in oil. Therefore, it is difficult to apply in formulations, and the dosage is also subject to certain restrictions. Studies have found that 1,2-hexanediol and octyldodecanol have certain solubility for phytosphingosine, and can dissolve phytosphingosine under heating conditions to obtain a clear and transparent oil solution. However, the low-temperature stability of the oil solution is poor. After cooling, phytosphingosine will slowly precipitate, causing the solution to no longer be clear and transparent.

[0007] In the present invention, 1,2-hexanediol, dipropylene glycol and octyldodecanol are compounded in a certain ratio, and the obtained mixed solvent can play a good synergistic solubilizing effect on phytosphingosine, so that the phytosphingosine can be completely dissolved in the mixed solvent after heating to form a clear and transparent oil solution; and the obtained oil solution also has good low-temperature stability, and after being placed at a low temperature of 4°C, no particles will precipitate, and the oil solution can still maintain a clear and transparent state.

[0008] In the oil-soluble composition of the present invention, the addition amount A of 1,2-hexanediol satisfies 4≤A≤96. For example, the value of A can be 4, 5, 6, 8, 10, 20, 30, 40, 50, 60, 70, 80, 90, 96, etc.

[0009] In the oil-soluble composition of the present invention, the added amount B of dipropylene glycol satisfies 4≤B≤96. Exemplarily, the value of B can be 4, 5, 6, 8, 10, 20, 30, 40, 50, 60, 70, 80, 90, 96, etc.

[0010] In the oil-soluble composition of the present invention, the addition amount C of octyldodecanol satisfies 0≤C≤250. For example, the value of C can be 0, 5, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, 250, etc.

[0011] In the oil-soluble composition of the present invention, the sum of the added amounts of 1,2-hexanediol, dipropylene glycol and octyldodecanol satisfies A+B+C≥28. For example, the value of A+B+C can be 28, 30, 32, 35, 40, 45, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, 250, etc.

[0012] In the oil-soluble composition of the present invention, the sum of the added amounts of 1,2-hexanediol and dipropylene glycol satisfies A+B≥14. For example, the value of A+B can be 14, 15, 16, 18, 20, 25, 30, 35, 40, 45, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, etc.

[0013] In some embodiments of the present invention, the oil-soluble composition consists of phytosphingosine, 1,2-hexanediol, dipropylene glycol and octyldodecanol.

[0014] In some embodiments of the present invention, only 1,2-hexanediol and dipropylene glycol can be used as a solvent to dissolve phytosphingosine, and a transparent oil solution with good stability can also be obtained. In this embodiment, the amount of 1,2-hexanediol and dipropylene glycol needs to be increased accordingly.

[0015] Specifically, in this embodiment, the oil-soluble composition of phytosphingosine includes phytosphingosine, 1,2-hexanediol and dipropylene glycol; in the oil-soluble composition, the mass ratio of phytosphingosine, 1,2-hexanediol and dipropylene glycol is 1:A:B, wherein A and B satisfy: 4≤A≤96, 4≤B≤96, and A+B≥28.

[0016] The second aspect of the present invention provides a method for preparing the oil-soluble composition of phytosphingosine, comprising the following steps: The phytosphingosine powder, dipropylene glycol, 1,2-hexanediol and optional octyldodecanol in a prescribed amount are mixed, heated and kept warm until they are completely dissolved; after stirring and cooling, the oil-soluble composition of the phytosphingosine is obtained.

[0017] The oil-soluble composition of phytosphingosine provided by the present invention can be prepared by only a few steps of mixing, heating to dissolve and stirring, without adopting a complicated preparation process.

[0018] In some preferred embodiments of the present invention, the heating temperature is 75-90°C, and illustratively, it can be 75°C, 76°C, 77°C, 78°C, 79°C, 80°C, 81°C, 82°C, 83°C, 84°C, 85°C, 86°C, 87°C, 88°C, 89°C, 90°C and the like; the insulation time is 10-25 min, and illustratively, it can be 10 min, 11 min, 12 min, 13 min, 14 min, 15 min, 16 min, 17 min, 18 min, 19 min, 20 min, 21 min, 22 min, 23 min, 24 min, 25 min and the like.

[0019] The third aspect of the present invention provides the use of the oil-soluble composition of phytosphingosine in cosmetics.

[0020] The fourth aspect of the present invention discloses a cosmetic comprising the above-mentioned oil-soluble composition of phytosphingosine.

[0021] In some preferred embodiments of the present invention, the cosmetics include but are not limited to essences, facial masks, creams, makeup products and skin care products.

[0022] Compared with the prior art, the present invention has the following beneficial effects: 1. The oil-soluble composition of phytosphingosine provided by the present invention is a clear and transparent oil solution, and the oil solution has good low-temperature stability. After being placed at a low temperature of 4°C, no particles will precipitate and the oil solution can still remain clear and transparent.

[0023] 2. The oil-soluble composition of phytosphingosine provided by the present invention has a very simple preparation process, which greatly reduces the application difficulty and production and application costs of phytosphingosine.

[0024] 3. The oil-soluble composition of phytosphingosine provided by the present invention can be applied to systems such as essences, facial masks, emulsions, makeup products and cleaning products, which not only facilitates the use of phytosphingosine in various cosmetic product formulas, but also can prepare pure and transparent oil products, thereby expanding the application prospects of phytosphingosine. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 is the structural formula of phytosphingosine; Figure 2 is a state diagram of the phytosphingosine oil solution of Examples 1 to 3 after being left to stand at 4° C.; Figure 3 It is a state diagram of the phytosphingosine oil solution of Example 4 and Examples 10-11 after being left to stand at 4°C; Figure 4 It is a state diagram of the phytosphingosine oil solution of Comparative Examples 1 to 3 after being left to stand at 4°C; Figure 5 This is a state diagram of the phytosphingosine oil solutions of Comparative Examples 7 to 9 after standing at 4°C. DETAILED DESCRIPTION

[0026] The present invention is further described below in conjunction with specific embodiments so that those skilled in the art can better understand the present invention and implement it, but the embodiments are not intended to limit the present invention.

[0027] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which the present invention belongs. The terms used in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more of the related listed items.

[0028] Unless otherwise specified, the experimental methods used in the following examples and comparative examples are all conventional methods, and the materials, reagents, etc. used are all commercially available unless otherwise specified.

[0029] Experiment 1: Example and Comparative Example Example 1

[0030] This embodiment provides an oil-soluble composition of phytosphingosine, which is composed of phytosphingosine, 1,2-hexanediol, dipropylene glycol and octyldodecanol, and the ratio of the three is 1:4:10:15.

[0031] The preparation process of the oil-soluble composition of phytosphingosine in this embodiment is as follows: According to the above ratio, phytosphingosine, 1,2-hexanediol, dipropylene glycol and octyldodecanol are mixed, heated to 80° C., and kept warm until clear and transparent; then stirred and cooled to room temperature to obtain an oil-soluble composition of phytosphingosine.

[0032] Embodiment 2~15

[0033] The preparation process of the phytosphingosine oil-soluble composition in Examples 2 to 15 is the same as that in Example 1, and the formula and transparency after standing are shown in Table 1.

[0034] Table 1

[0035] Comparative Examples 1 to 9 The preparation process of the phytosphingosine oil-soluble composition in Comparative Examples 1 to 9 is the same as that in Example 1, and the formula and transparency after standing are shown in Table 2.

[0036] Table 2

[0037] As can be seen from Table 2, in Comparative Examples 6 to 8, when only one of 1,2-hexanediol, dipropylene glycol, and octyldodecanol is used as a solvent, phytosphingosine can be dissolved under heating conditions to obtain a clear and transparent oil solution at 80°C; however, the low-temperature stability of the oil solution is poor. Figure 5 As shown, when the oil solutions in Comparative Examples 7-8 were cooled to 4°C, obvious particle precipitation occurred.

[0038] In comparative example 2, the amount of 1,2-hexanediol added in the compound solvent is A=0; in comparative example 3, the amount of dipropylene glycol added in the compound solvent is B=0. Since the conditions of 4≤A≤96 and 4≤B≤96 are not met, the compound solvent has a poor solubilizing effect on phytosphingosine. Although a clear and transparent oil solution can be obtained under heating conditions, its low-temperature stability is poor. Figure 4 As shown, the oil solutions in Comparative Examples 2-3 become turbid when cooled to 4°C.

[0039] In comparative example 5, the total amount of 1,2-hexanediol and dipropylene glycol added in the compound solvent is A+B=13; in comparative example 9, the total amount of 1,2-hexanediol and dipropylene glycol added in the compound solvent is A+B=9. Since the condition of A+B≥14 is not met, the compound solvent has a poor solubilizing effect on phytosphingosine. Although a clear and transparent oil solution can be obtained under heating conditions, its low-temperature stability is poor, and obvious particle precipitation will occur when the oil solution is left to cool to 4°C.

[0040] In comparative example 1, the total amount of 1,2-hexanediol, dipropylene glycol and octyldodecanol added in the compound solvent is A+B+C=26; in comparative example 4, the total amount of 1,2-hexanediol, dipropylene glycol and octyldodecanol added in the compound solvent is A+B+C=25. Since the condition of A+B+C≥28 is not met, the compound solvent has a poor solubilizing effect on phytosphingosine. Although a clear and transparent oil solution can be obtained under heating conditions, its low-temperature stability is poor. As shown in the attached Figure 4 As shown, when the oil solution in Comparative Example 1 was cooled to 4°C, obvious particle precipitation occurred.

[0041] As can be seen from Table 1, in Examples 1 to 15, the addition amount A of 1,2-hexanediol, the addition amount B of dipropylene glycol, and the addition amount C of octyldodecanol in the compound solvent all meet the following conditions: 4≤A≤96, 4≤B≤96, 0≤C≤250, and A+B+C≥28, A+B≥14. At this time, the compound solvent exhibits a good solubilizing effect on phytosphingosine, and can not only dissolve under heating conditions to obtain a clear and transparent oil solution, but also the oil solution has good low temperature stability. Figure 2~3 As shown, when the oil solutions in Examples 1 to 4 and Examples 10 to 11 are cooled to 4° C., no particles are precipitated and no turbidity occurs, and the oil solutions remain clear and transparent.

[0042] Experiment 2: Application Example 1. Phytosphingosine essential oil

[0043] This application case provides a phytosphingosine essential oil, the formula of which is shown in Table 3.

[0044] Table 3

[0045] The preparation process of the phytosphingosine essential oil in this application case is: Heat phase A to above 80°C and dissolve it until transparent, then add phase B and stir evenly.

[0046] 2. Phytosphingosine milk

[0047] This application case provides a phytosphingosine milk, the formula of which is shown in Table 4.

[0048] Table 4

[0049] The preparation process of phytosphingosine milk in this application case is: First, heat phase A2 to 70℃ and dissolve until transparent for later use; then heat phase A1 and phase B to 80℃ respectively, and then add phase B to phase A1 for emulsification and homogenization; then add phase A2 and continue homogenization, and then add phase C and homogenize for 2-3 minutes; stir and cool to 45℃, add phase D and phase E (heat phase E to no more than 60℃ and dissolve until transparent), stir evenly, and you have it.

[0050] 3. Phytosphingosine Cream

[0051] This application case provides a phytosphingosine cream, the formula of which is shown in Table 5.

[0052] Table 5

[0053] The preparation process of the phytosphingosine cream in this application case is: First, heat phase A2 to 70℃ and dissolve it until transparent for later use; then heat phase A1 and phase B to 80℃ respectively, then add phase B into phase A1 and emulsify and homogenize, then add phase A2 and continue homogenizing; stir and cool to 45℃, add phase D and phase E (heat E to no more than 60℃ and dissolve it until transparent), stir evenly, and you have it.

[0054] 4. Phytosphingosine Gel

[0055] This application case provides a phytosphingosine gel, the formula of which is shown in Table 6.

[0056] Table 6

[0057] The preparation process of phytosphingosine gel in this application case is: Heat phase A2 to 70℃ and dissolve until transparent for later use; then heat phase A1 and phase B to 80℃ respectively, and then add phase B to phase A1 for emulsification and homogenization; then add phase A2 and continue homogenization, and then add phase C and homogenize for 2-3 minutes; stir and cool to 45℃, add phase D1 and phase D2 (heat phase D2 at no more than 60℃ and dissolve until transparent), stir evenly, and you have it.

[0058] 5. Phytosphingosine Essence

[0059] This application case provides a phytosphingosine essence, the formula of which is shown in Table 7.

[0060] Table 7

[0061] The preparation process of the phytosphingosine extract in this application case is: Heat phase A2 to 70℃ and dissolve until transparent for later use; then heat phase A1 and phase B to 80℃ respectively, and then add phase B to phase A1 for emulsification and homogenization; then add phase A2 and continue homogenization, and then add phase C and homogenize for 2-3 minutes; stir and cool to 45℃, add phase D (heat phase D to no more than 60℃ and dissolve until transparent), stir evenly, and you have it.

[0062] 6. Phytosphingosine facial mask

[0063] This application case provides a phytosphingosine facial mask solution, the formula of which is shown in Table 8.

[0064] Table 8

[0065] The preparation process of the phytosphingosine facial mask liquid in this application case is: Heat phase A2 to 70℃ and dissolve until transparent for later use; then heat phase A1 and phase B to 80℃ respectively, and then add phase B to phase A1 for emulsification and homogenization; then add phase A2 and continue homogenization; stir and cool to 45℃, add phase D (heat phase D to no more than 60℃ and dissolve until transparent), stir evenly, and you have it.

[0066] In summary, the present invention provides an oil-soluble composition of phytosphingosine, which is a clear and transparent oil solution, which not only facilitates the use of phytosphingosine in various cosmetic product formulas, but also can prepare pure and transparent oil products, expanding the application prospects of phytosphingosine; and the preparation process of the oil-soluble composition is simple, which greatly reduces the application difficulty of phytosphingosine, and is conducive to reducing the application costs of factories and consumers.

[0067] The above-described embodiments are only preferred embodiments for fully illustrating the present invention, and the protection scope of the present invention is not limited thereto. Equivalent substitutions or changes made by those skilled in the art based on the present invention are within the protection scope of the present invention. The protection scope of the present invention shall be subject to the claims.

Claims

1. An oil-soluble composition of phytosphingosine, characterized in that: These include phytosphingosine, 1,2-hexanediol, dipropylene glycol, and octyldodecanol; In the oil-soluble composition, the mass ratio of phytosphingosine, 1,2-hexanediol, dipropylene glycol and octyldodecanol is 1:A:B:C, wherein A, B and C satisfy: 4≤A≤96, 4≤B≤96, 0≤C≤250, and A+B+C≥28, A+B≥14.

2. The oil-soluble composition of phytosphingosine according to claim 1, characterized in that: The oil-soluble composition of phytosphingosine is a clear and transparent oil solution.

3. The oil-soluble composition of phytosphingosine according to claim 1, characterized in that: The oil-soluble composition comprises phytosphingosine, 1,2-hexanediol and dipropylene glycol; In the oil-soluble composition, the mass ratio of phytosphingosine, 1,2-hexanediol and dipropylene glycol is 1:A:B, wherein A and B satisfy: 4≤A≤96, 4≤B≤96, and A+B≥28.

4. A method for preparing the oil-soluble composition of phytosphingosine as claimed in claim 1, characterized in that: The following steps are involved: The phytosphingosine powder, 1,2-hexanediol, dipropylene glycol and octyldodecanol in a prescribed amount are mixed, heated and kept warm until they are completely dissolved; after stirring and cooling, the oil-soluble composition of the phytosphingosine is obtained.

5. The method for preparing the oil-soluble composition of phytosphingosine according to claim 4, characterized in that: The heating temperature is 75-90° C., and the insulation time is 10-25 min.

6. Use of the oil-soluble composition of phytosphingosine according to any one of claims 1 to 3 in cosmetics.

7. A cosmetic, characterized in that: The cosmetic comprises the oil-soluble composition of phytosphingosine according to any one of claims 1 to 3.

8. The cosmetic according to claim 7, characterized in that: The cosmetics include: essence, facial mask, cream, makeup products and cleaning products.

Images