Formula system for improving solubility and stability of ceramide NP and preparation method

Abstract

The invention provides a formula system for improving solubility and stability of ceramide NP and a preparation method, and belongs to the field of cosmetics. The formula system comprises an active component, an emulsifier, a thickening agent and a solvent, the active component is ceramide NP; the emulsifier comprises at least one of an anionic emulsifier, a natural polymer emulsifier, a nonionic emulsifier and a phospholipid emulsifier; the solvent comprises water, polyhydric alcohol and an oil-soluble solvent. According to the formula system provided by the invention, the stability of the oil-in-water cosmetic containing more ceramide NP is greatly improved by selecting the proper emulsifier, thickener and solvent, and the formula system has unexpected technical effects.

Description

Technical Field

[0001] The present invention relates to the field of cosmetics, and in particular to a formula system and a preparation method for improving the solubility and stability of ceramide NP. Background Art

[0002] Ceramide is a lipid found naturally in the skin. Ceramide forms a waterproof barrier on the surface of the skin. The skin of newborn babies is often covered with a waxy substance called vernix caseosa, which is mainly composed of ceramide, which can prevent the loss of moisture from the skin. The secretion of ceramide in the skin decreases with age, which leads to dry skin, wrinkles and some skin inflammation.

[0003] Ceramide NP is a class of compounds composed of sphingosine bottom chain and amide fatty acid, and has long-chain fatty acids in its structure. Due to its structural characteristics, the water-in-oil emulsion system containing a high content of ceramide NP is difficult to stabilize, and it is difficult to pass the high and low temperature stability, and separation or chromatography may occur.

[0004] In addition, ceramide NPs have poor stability under high temperature and light conditions and are prone to degradation. Therefore, how to improve the stability of ceramide NPs in products remains a difficult problem that needs to be solved urgently.

[0005] Therefore, there is still an urgent need for a ceramide NP composition that is easy to emulsify, simple to operate, and has good emulsification system stability. Summary of the invention

[0006] In order to solve the above technical problems, the present invention provides the following technical solutions.

[0007] In a first aspect, the present invention provides a composition comprising ceramide NPs.

[0008] A composition comprising: an active ingredient, an emulsifier, a thickener and a solvent; The active ingredient is ceramide NP; The emulsifier includes at least one of anionic emulsifier, natural polymer emulsifier, nonionic emulsifier and phospholipid emulsifier; The solvents include water, polyols and oil-soluble solvents.

[0009] In some embodiments, the thickening agent is propylene glycol alginate.

[0010] In some embodiments, the anionic emulsifier is sodium stearoyl glutamate.

[0011] In some embodiments, the natural polymer emulsifier is inulin lauryl carbamate.

[0012] In some embodiments, the nonionic emulsifier is polyglyceryl-10 stearate.

[0013] In some embodiments, the phospholipid emulsifier is lecithin.

[0014] In some embodiments, the polyol includes at least one of butylene glycol, propylene glycol, and dipropylene glycol. In some preferred embodiments, the polyol is 1,3-butylene glycol, which is more conducive to improving the stability of the appearance, viscosity, and ceramide NP content of the obtained composition under conditions such as high temperature, refrigeration (0°C), freezing (-15°C), room temperature, light, high and low temperature cycles, etc.

[0015] In some embodiments, the oil-soluble solvent includes at least one of an alkyl alcohol solvent, tri(ethylhexanoin), caprylic / capric triglyceride, isononyl isononanoate, etc. In some embodiments, the oil-soluble solvent is preferably an alkyl alcohol solvent, which is beneficial to improve the stability of the appearance, viscosity, and ceramide NP content of the obtained composition under conditions such as high temperature, refrigeration (0°C), freezing (-15°C), room temperature, light, and high and low temperature cycles. In some embodiments, the oil-soluble solvent is more preferably octyldodecanol, which is more beneficial to improve the stability of the appearance, viscosity, and ceramide NP content of the obtained composition under conditions such as high temperature, refrigeration (0°C), freezing (-15°C), room temperature, light, and high and low temperature cycles.

[0016] In some embodiments, the solvent is preferably water, 1,3-butanediol and octyldodecanol, which is beneficial to improve the appearance, viscosity and stability of the ceramide NP content of the obtained composition under conditions such as high temperature, refrigeration (0°C), freezing (-15°C), room temperature, light, high and low temperature cycles, etc.

[0017] In some embodiments, the content of the ceramide NP is 0.010wt%-2.000wt% based on the total weight of the composition. In some embodiments, the content of the ceramide NP is 0.010wt%, 0.050wt%, 0.100wt%, 0.500wt%, 1.000wt%, 1.500wt% or 2.000wt% based on the total weight of the composition.

[0018] In some embodiments, the content of the anionic emulsifier is 0.010 wt%-0.400 wt% based on the total mass of the composition. In some embodiments, the content of the anionic emulsifier is 0.010 wt%, 0.100 wt%, 0.200 wt%, 0.300 wt% or 0.400 wt% based on the total mass of the composition.

[0019] In some embodiments, the content of the natural polymer emulsifier is 0.050 wt%-1.000 wt% based on the total mass of the composition. In some embodiments, the content of the natural polymer emulsifier is 0.050 wt%, 0.100 wt%, 0.150 wt%, 0.200 wt%, 0.250 wt%, 0.300 wt%, 0.350 wt% or 1.000 wt% based on the total mass of the composition.

[0020] In some embodiments, the content of the nonionic emulsifier is 0.100wt%-3.000wt% based on the total mass of the composition. In some embodiments, the content of the nonionic emulsifier is 0.100wt%, 0.200wt%, 0.300wt%, 0.400wt%, 0.500wt%, 1.000wt%, 1.500wt%, 2.000wt%, 2.500wt% or 3.000wt% based on the total mass of the composition. In some embodiments, the content of the nonionic emulsifier is 0.100wt%-0.400wt% based on the total mass of the composition.

[0021] In some embodiments, the content of the phospholipid emulsifier is 0.010wt%-0.600wt% based on the total mass of the composition. In some embodiments, the content of the phospholipid emulsifier is 0.010 wt%, 0.050 wt%, 0.100 wt%, 0.150 wt%, 0.200 wt%, 0.300 wt%, 0.400 wt%, 0.500wt% or 0.600wt% based on the total mass of the composition.

[0022] In some embodiments, the content of the thickener is 0.0002 wt%-0.500 wt% based on the total mass of the composition. In some embodiments, the content of the thickener is 0.0002 wt%, 0.0010 wt%, 0.0050 wt%, 0.010 wt%, 0.020 wt%, 0.030 wt%, 0.040 wt%, 0.100 wt%, 0.200 wt%, 0.300 wt%, 0.400 wt% or 0.500 wt% based on the total mass of the composition.

[0023] In some embodiments, the content of the polyol is 2.000wt%-12.000wt% based on the total mass of the composition. In some embodiments, the content of the polyol is 2.000wt%, 3.000wt%, 3.500wt%, 4.000wt%, 5.000wt%, 6.000wt%, 7.000wt%, 8.000wt%, 9.000wt%, 10.000wt%, 11.000wt% or 12.000wt% based on the total mass of the composition.

[0024] In some embodiments, the oil-soluble solvent is an alkyl alcohol solvent, and the content of the alkyl alcohol solvent is 0.200 wt%-7.000wt%, calculated based on the total mass of the composition. In some embodiments, the oil-soluble solvent is an alkyl alcohol solvent, and the content of the alkyl alcohol solvent is 0.200 wt%, 0.500 wt%, 1.000 wt%, 2.000 wt%, 3.000 wt%, 4.000 wt%, 5.000 wt%, 6.000 wt% or 7.000wt%, calculated based on the total mass of the composition.

[0025] In some embodiments, calculated based on the total mass of the composition, the content of the ceramide NP is 0.010wt%-2.000wt%, the content of the anionic emulsifier is 0.010 wt%-0.400wt%, the content of the natural polymer emulsifier is 0.050 wt%-1.000wt%, the content of the non-ionic emulsifier is 0.100wt%-3.000wt%, the content of the phospholipid emulsifier is 0.010wt%-0.600wt%, the content of the thickener is 0.0002 wt%-0.500wt%, the content of the polyol is 2.000wt%-5.000wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 0.200 wt%-7.000wt%, and the balance is water.

[0026] In some embodiments, calculated based on the total mass of the composition, the content of the ceramide NP is 0.010wt%, the content of the anionic emulsifier is 0.010 wt%, the content of the nonionic emulsifier is 0.100wt%, the content of the natural polymer emulsifier is 0.050 wt%, the content of the phospholipid emulsifier is 0.010 wt%, the content of the thickener is 0.0002 wt%, the content of the polyol is 3.500wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 0.200wt%, and the balance is water.

[0027] In some embodiments, calculated based on the total mass of the composition, the content of the ceramide NP is 2.000wt%, the content of the anionic emulsifier is 0.400wt%, the content of the nonionic emulsifier is 3.000wt%, the content of the natural polymer emulsifier is 1.000wt%, the content of the phospholipid emulsifier is 0.600wt%, the content of the thickener is 0.500wt%, the content of the polyol is 3.500wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 7.000wt%, and the balance is water.

[0028] In some embodiments, calculated based on the total mass of the composition, the content of the ceramide NP is 1.000wt%, the content of the anionic emulsifier is 0.300wt%, the content of the nonionic emulsifier is 1.000wt%, the content of the natural polymer emulsifier is 0.500wt%, the content of the phospholipid emulsifier is 0.200wt%, the content of the thickener is 0.300wt%, the content of the polyol is 3.500wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 5.000wt%, and the balance is water.

[0029] In some embodiments, calculated based on the total mass of the composition, the content of the ceramide NP is 1.000wt%, the content of the anionic emulsifier is 0.300wt%, the content of the nonionic emulsifier is 1.000wt%, the content of the natural polymer emulsifier is 0.200wt%, the content of the phospholipid emulsifier is 0.200wt%, the content of the thickener is 0.300wt%, the content of the polyol is 3.500wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 5.000wt%, and the balance is water.

[0030] In some embodiments, the thickener is propylene glycol alginate; the anionic emulsifier is sodium stearoyl glutamate; the natural polymer emulsifier is inulin lauryl carbamate; the nonionic emulsifier is polyglyceryl-10 stearate; the phospholipid emulsifier is lecithin; the solvent includes water, a polyol and an oil-soluble solvent; the polyol is 1,3-butylene glycol; and the oil-soluble solvent is octyldodecanol.

[0031] In some embodiments, the thickener is propylene glycol alginate; the anionic emulsifier is sodium stearoyl glutamate; the natural polymer emulsifier is inulin lauryl carbamate; the nonionic emulsifier is polyglycerol-10 stearate; the phospholipid emulsifier is lecithin; the solvent includes water, polyols and oil-soluble solvents; the polyol is 1,3-butylene glycol; the oil-soluble solvent is octyldodecanol; calculated based on the total mass of the composition, the content of the ceramide NP is 0.010 wt%-2.000wt%, the content of the anionic emulsifier is 0.010 wt%-0.400wt%, and the content of the natural polymer emulsifier is 0.050 wt%-1.000wt%, the content of the nonionic emulsifier is 0.100wt%-3.000wt%, the content of the phospholipid emulsifier is 0.010wt%-0.600wt%, the content of the thickener is 0.0002wt%-0.500wt%, the content of the polyol is 2.000wt%-5.000wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 0.200 wt%-7.000wt%, and the balance is water.

[0032] In some embodiments, the thickener is propylene glycol alginate; the anionic emulsifier is sodium stearoyl glutamate; the natural polymer emulsifier is inulin lauryl carbamate; the nonionic emulsifier is polyglycerol-10 stearate; the phospholipid emulsifier is lecithin; the solvent includes water, polyols and oil-soluble solvents; the polyol is 1,3-butylene glycol; the oil-soluble solvent is octyldodecanol; calculated based on the total mass of the composition, the content of ceramide NP is 0.010 wt%, the content of the anionic emulsifier is 0.010 wt%, the content of the nonionic emulsifier is 0.100 wt%, the content of the natural polymer emulsifier is 0.050 wt%, the content of the phospholipid emulsifier is 0.010 wt%, and the content of the thickener is 0.0002 wt%, the content of the polyol is 3.500wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 0.200wt%, and the balance is water.

[0033] In some embodiments, the thickener is propylene glycol alginate; the anionic emulsifier is sodium stearoyl glutamate; the natural polymer emulsifier is inulin lauryl carbamate; the nonionic emulsifier is polyglycerol-10 stearate; the phospholipid emulsifier is lecithin; the solvent includes water, polyol and oil-soluble solvent; the polyol is 1,3-butylene glycol; the oil-soluble solvent is octyldodecanol; calculated based on the total mass of the composition, the content of ceramide NP is 2.0 00wt%, the content of the anionic emulsifier is 0.400wt%, the content of the nonionic emulsifier is 3.000wt%, the content of the natural polymer emulsifier is 1.000wt%, the content of the phospholipid emulsifier is 0.600wt%, the content of the thickener is 0.500wt%, the content of the polyol is 3.500wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 7.000wt%, and the balance is water.

[0034] In some embodiments, the thickener is propylene glycol alginate; the anionic emulsifier is sodium stearoyl glutamate; the natural polymer emulsifier is inulin lauryl carbamate; the nonionic emulsifier is polyglycerol-10 stearate; the phospholipid emulsifier is lecithin; the solvent includes water, polyol and oil-soluble solvent; the polyol is 1,3-butylene glycol; the oil-soluble solvent is octyldodecanol; calculated based on the total mass of the composition, the content of ceramide NP is 1.0 00wt%, the content of the anionic emulsifier is 0.300wt%, the content of the nonionic emulsifier is 1.000wt%, the content of the natural polymer emulsifier is 0.500wt%, the content of the phospholipid emulsifier is 0.200wt%, the content of the thickener is 0.300wt%, the content of the polyol is 3.500wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 5.000wt%, and the balance is water.

[0035] In some embodiments, the thickener is propylene glycol alginate; the anionic emulsifier is sodium stearoyl glutamate; the natural polymer emulsifier is inulin lauryl carbamate; the nonionic emulsifier is polyglycerol-10 stearate; the phospholipid emulsifier is lecithin; the solvent includes water, polyol and oil-soluble solvent; the polyol is 1,3-butylene glycol; the oil-soluble solvent is octyldodecanol; calculated based on the total mass of the composition, the content of ceramide NP is 1.0 00wt%, the content of the anionic emulsifier is 0.300wt%, the content of the nonionic emulsifier is 1.000wt%, the content of the natural polymer emulsifier is 0.200wt%, the content of the phospholipid emulsifier is 0.200wt%, the content of the thickener is 0.300wt%, the content of the polyol is 3.500wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 5.000wt%, and the balance is water.

[0036] In some embodiments, the thickener is propylene glycol alginate; the anionic emulsifier is sodium stearoyl glutamate; the natural polymer emulsifier is inulin lauryl carbamate; the nonionic emulsifier is polyglycerol-10 stearate; the phospholipid emulsifier is lecithin; the solvent includes water, a polyol and an oil-soluble solvent; the polyol is 1,3-butylene glycol; and the oil-soluble solvent includes an alkyl alcohol solvent.

[0037] In some embodiments, the thickener is propylene glycol alginate; the anionic emulsifier is sodium stearoyl glutamate; the natural polymer emulsifier is inulin lauryl carbamate; the nonionic emulsifier is polyglycerol-10 stearate; the phospholipid emulsifier is lecithin; the solvent includes water, polyols and oil-soluble solvents; the polyol is 1,3-butylene glycol; the oil-soluble solvent includes an alkyl alcohol solvent; calculated based on the total mass of the composition, the content of the ceramide NP is 0.010 wt%-2.000wt%, the content of the anionic emulsifier is 0.010 wt%-0.400wt%, and the content of the natural polymer emulsifier is 0.050 wt%-1.000wt%, the content of the nonionic emulsifier is 0.100wt%-3.000wt%, the content of the phospholipid emulsifier is 0.010wt%-0.600wt%, the content of the thickener is 0.0002wt%-0.500wt%, the content of the polyol is 2.000wt%-5.000wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 0.200 wt%-7.000wt%, and the balance is water.

[0038] In some embodiments, the thickener is propylene glycol alginate; the anionic emulsifier is sodium stearoyl glutamate; the natural polymer emulsifier is inulin lauryl carbamate; the nonionic emulsifier is polyglycerol-10 stearate; the phospholipid emulsifier is lecithin; the solvent includes water, polyols and oil-soluble solvents; the polyol is 1,3-butylene glycol; the oil-soluble solvent includes an alkyl alcohol solvent; calculated based on the total mass of the composition, the content of the ceramide NP is 0.010 wt%, the content of the anionic emulsifier is 0.010 wt%, the content of the nonionic emulsifier is 0.100 wt%, the content of the natural polymer emulsifier is 0.050 wt%, the content of the phospholipid emulsifier is 0.010 wt%, and the content of the thickener is 0.0002 wt%, the content of the polyol is 3.500wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 0.200wt%, and the balance is water.

[0039] In some embodiments, the thickener is propylene glycol alginate; the anionic emulsifier is sodium stearoyl glutamate; the natural polymer emulsifier is inulin lauryl carbamate; the nonionic emulsifier is polyglycerol-10 stearate; the phospholipid emulsifier is lecithin; the solvent includes water, polyol and oil-soluble solvent; the polyol is 1,3-butylene glycol; the oil-soluble solvent includes alkyl alcohol solvent; calculated based on the total mass of the composition, the content of ceramide NP is 2. 000wt%, the content of the anionic emulsifier is 0.400wt%, the content of the nonionic emulsifier is 3.000wt%, the content of the natural polymer emulsifier is 1.000wt%, the content of the phospholipid emulsifier is 0.600wt%, the content of the thickener is 0.500wt%, the content of the polyol is 3.500wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 7.000wt%, and the balance is water.

[0040] In some embodiments, the thickener is propylene glycol alginate; the anionic emulsifier is sodium stearoyl glutamate; the natural polymer emulsifier is inulin lauryl carbamate; the nonionic emulsifier is polyglycerol-10 stearate; the phospholipid emulsifier is lecithin; the solvent includes water, polyol and oil-soluble solvent; the polyol is 1,3-butylene glycol; the oil-soluble solvent includes alkyl alcohol solvent; calculated based on the total mass of the composition, the content of ceramide NP is 1. 000wt%, the content of the anionic emulsifier is 0.300wt%, the content of the nonionic emulsifier is 1.000wt%, the content of the natural polymer emulsifier is 0.500wt%, the content of the phospholipid emulsifier is 0.200wt%, the content of the thickener is 0.300wt%, the content of the polyol is 3.500wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 5.000wt%, and the balance is water.

[0041] In some embodiments, calculated based on the total mass of the composition, the content of the ceramide NP is 1.000wt%, the content of the anionic emulsifier is 0.300wt%, the content of the nonionic emulsifier is 1.000wt%, the content of the natural polymer emulsifier is 0.200wt%, the content of the phospholipid emulsifier is 0.200wt%, the content of the thickener is 0.300wt%, the content of the polyol is 3.500wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 5.000wt%, and the balance is water.

[0042] In a second aspect, the present invention provides a method for preparing the composition of the first aspect.

[0043] A method for preparing the composition of the first aspect, characterized in that it comprises the following steps: Step (1): mixing and dispersing the components in component 2 to obtain a mixed solution of component 2; then mixing and heating the components in component 1 to obtain a mixed solution of component 1, adding the mixed solution of component 2 to the mixed solution of component 1, homogenizing, and defoaming to obtain a mixture A; the component 1 comprises water, an anionic emulsifier, a phospholipid emulsifier, a natural polymer emulsifier, and a part of the formula amount of polyol; the component 2 comprises a thickener and the remaining formula amount of polyol; Step (2): heating and dissolving component 3 to obtain a mixture B; the component 3 comprises a nonionic emulsifier, an active ingredient and an oil-soluble solvent; Step (3): Mixing the mixture A and the mixture B, homogenizing, and defoaming to obtain the composition.

[0044] In some embodiments, the partial amount of polyol in step (1) is three-sevenths to five-sevenths of the amount of polyol. In some embodiments, the partial amount of polyol in step (1) is four-sevenths of the amount of polyol.

[0045] In some embodiments, the temperature of the heated component 1 in step (1) is 80° C. to 90° C. In some embodiments, the temperature of the heated component 1 in step (1) is 80° C., 85° C. or 90° C.

[0046] In some embodiments, the homogenization speed of the step (1) is 2500 rpm-3500 rpm. In some embodiments, the homogenization speed of the step (1) is 2500 rpm, 3000 rpm or 3500 rpm.

[0047] In some embodiments, the homogenization time of step (1) is 2 minutes to 6 minutes. In some embodiments, the homogenization time of step (1) is 2 minutes, 3 minutes, 4 minutes, 5 minutes or 6 minutes.

[0048] In some embodiments, the defoaming in step (1) is vacuum defoaming.

[0049] In some embodiments, the temperature of heating and dissolving in step (2) is 80°C-95°C. In some embodiments, the temperature of heating and dissolving in step (2) is 80°C, 85°C, 90°C or 95°C.

[0050] In some embodiments, the homogenization speed of the step (3) is 2500 rpm-3500 rpm. In some embodiments, the homogenization speed of the step (3) is 2500 rpm, 3000 rpm or 3500 rpm.

[0051] In some embodiments, the homogenization time of step (3) is 2 minutes to 8 minutes. In some embodiments, the homogenization time of step (3) is 2 minutes, 3 minutes, 4 minutes, 5 minutes, 6 minutes, 7 minutes or 8 minutes.

[0052] In some embodiments, the defoaming in step (3) is vacuum defoaming.

[0053] In a third aspect, the present invention provides use of the composition of the first aspect or the composition prepared by the method of the second aspect.

[0054] A use of the composition of the first aspect or the composition prepared by the method of the second aspect in preparing cosmetics.

[0055] Beneficial Effects Compared with the prior art, the technical solution provided by the present invention has at least one of the following beneficial technical effects: (1) Compared with the formulation lacking any one of the natural polymer emulsifier, phospholipid emulsifier and anionic emulsifier, the formulation obtained by using the natural polymer emulsifier, phospholipid emulsifier and anionic emulsifier as emulsifiers at the same time has better appearance and stability of appearance, viscosity and ceramide NP content under conditions such as high temperature, refrigeration (0°C), freezing (-15°C), room temperature, light, high and low temperature cycle, etc., indicating that the natural polymer emulsifier, phospholipid emulsifier and anionic emulsifier provided by the present invention play a synergistic role with each other.

[0056] (2) Compared with other oil-soluble solvents (such as caprylic acid / capric acid triglyceride), the alkyl alcohol solvent (such as octyldodecanol) provided by the present invention is more conducive to improving the appearance and stability of the appearance, viscosity and ceramide NP content of the obtained ceramide NP composition under conditions such as high temperature, refrigeration (0°C), freezing (-15°C), room temperature, light, high and low temperature cycles, etc., and has unexpected technical effects.

[0057] (3) Compared with other natural polymer emulsifiers (such as glyceryl stearate citrate, coconut glucoside or arachidyl glucoside), the natural polymer emulsifier (such as inulin lauryl carbamate) provided by the present invention is more conducive to improving the appearance and stability of the appearance, viscosity and ceramide NP content of the obtained ceramide NP composition under conditions such as high temperature, refrigeration (0°C), freezing (-15°C), room temperature, light, high and low temperature cycles, etc., and has unexpected technical effects.

[0058] (4) Compared with other phospholipid emulsifiers (such as hydrogenated lysolecithin, hydrogenated lecithin or hydroxylated lecithin), the lecithin provided by the present invention is more conducive to improving the appearance and stability of the appearance, viscosity and ceramide NP content of the obtained ceramide NP composition under conditions such as high temperature, refrigeration (0°C), freezing (-15°C), room temperature, light, high and low temperature cycles, etc., and has unexpected technical effects.

[0059] (5) Compared with other thickeners (such as caesalpinia spinosa gum, xanthan gum or hydrogenated xanthan gum), the use of propylene glycol alginate provided by the present invention as a thickener is more conducive to improving the appearance and stability of the appearance, viscosity and ceramide NP content of the obtained ceramide NP composition under conditions such as high temperature, refrigeration (0°C), freezing (-15°C), room temperature, light, high and low temperature cycles, etc., and has unexpected technical effects.

[0060] (7) The ceramide NP composition provided by the present invention has good appearance and shape, and good stability in appearance and shape, viscosity and ceramide NP content, and has excellent technical effects.

[0061] Terminology In the above text of the present invention, regardless of whether the words "about" or "approximately" are used, all the numbers disclosed herein are approximate values. Based on the disclosed numbers, the value of each number may vary by less than ±10% or reasonable differences considered by those skilled in the art, such as ±1%, ±2%, ±3%, ±4% or ±5%.

[0062] The term "room temperature" means ambient temperature, which refers to a temperature between about 15°C and about 35°C, or between about 20°C and 30°C, or about 25°C.

[0063] The terms "optional", "optional" or "optionally" mean that the subsequently described event or circumstance may but need not occur.

[0064] The term "and / or" should be understood to mean any one of the optional items or a combination of any two or more of the optional items.

[0065] The term "wt%" means percent by mass.

[0066] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art may combine and combine the different embodiments or examples described in this specification and the features of the different embodiments or examples, without contradiction.

[0067] The structure of "ceramide NP" described in the present invention is:

[0068] The term "illuminant D65" is also known as the international standard artificial daylight (Artificial Daylight), whose color temperature is 6500K and its spectrum is similar to natural daylight.

[0069] The term "TL84 light source" refers to a tri-color fluorescent light source with a color temperature of 4000K. DETAILED DESCRIPTION

[0070] In order to enable those skilled in the art to better understand the technical solution of the present invention, some non-limiting embodiments are further disclosed below to further illustrate the present invention in detail.

[0071] The reagents used in the present invention can be purchased from the market or prepared by the method described in the present invention.

[0072] The detection method of ceramide NP content can refer to the following literature or other existing technical methods for detection: Zhao Gege, Su Wenrou, Wang Feifei. Determination of ceramide NP and AP content in liposomes by high performance liquid chromatography-evaporative light scattering method [J]. Daily Detergent Industry (Chinese and English), 2023, 53(12): 1466-1471. Example 1-Example 4: Preparation of Ceramide NP Compositions Recipe: See Table 1.

[0073] Table 1: Ceramide NP composition formula Preparation method: Step (1): Mix and disperse the components in component 2 to obtain a component 2 mixed solution; then mix the components in component 1 and heat to 80° C. to obtain a component 1 mixed solution, add the component 2 mixed solution to the component 1 mixed solution, homogenize (homogenizing speed 2000 rpm (can be 2000 rpm-3000 rpm), time 2 minutes (can be 2 minutes-6 minutes)), defoam, and obtain a mixture A; Step (2): Mix the components of component 3, heat to 80°C (can be 80-90°C) to dissolve, and obtain mixture B; Step (3): Mix the mixture A and the mixture B, homogenize (homogenizing speed 2500 rpm (can be 2500 rpm-3500 rpm), time 3 minutes (can be 2 minutes-8 minutes)), defoam, and cool to room temperature to obtain the composition.

[0074] Comparative Examples 1-5: Ceramide NP compositions lacking a single component Recipe: See Table 2.

[0075] Table 2: Compositions of ceramide NPs lacking a single component Preparation method: Prepare according to the method of Example 3 (components with a formula content of 0 are not added).

[0076] Comparative Example 6: Investigation of Oil-soluble Solvents in Component 3 of Ceramide NP Composition Formula Recipe: See Table 3.

[0077] Table 3: Preparation method: Prepared according to the method of Example 3.

[0078] Comparative Examples 7-9: Investigation of Natural Polymer Emulsifiers Recipe: See Table 4.

[0079] Table 4: Natural polymer emulsifier formulations Preparation method: Prepared according to the method in Example 3.

[0080] Comparative Example 10-Comparative Example 12: Investigation of phospholipid emulsifiers Recipe: See Table 5.

[0081] Table 5: Investigation of formulas of phospholipid emulsifiers Preparation method: Prepared according to the method in Example 3.

[0082] Comparative Example 13-Comparative Example 15: Investigation of Thickener Recipe: See Table 6.

[0083] Table 6: Thickener formulations investigated Preparation method: Prepared according to the method in Example 3.

[0084] Test Example 1: Stability Study 30 mL of the composition obtained in each of the above embodiments and comparative examples were taken respectively, and placed under 50°C, 0°C, light, room temperature (25°C), and high and low temperature cycle conditions to test the product stability (appearance, viscosity, ceramide NP content (ceramide NP content indicates the percentage of the measured concentration of ceramide NP to the theoretical concentration, and the content is mixed before detection)), and the test time was 3 months.

[0085] Lighting test: Place the sample to be tested in a light box and expose it to light (D65 light source: simulated sunlight, 10000 lux; TL84 light source: simulated counter light source, 500 lux).

[0086] High and low temperature cycle: Place the sample to be tested in a high and low temperature cycle box, and set the conditions as follows: place it at 45°C for 24 hours, then return to room temperature for 12 hours, then place it at 15°C for 24 hours, and then return to room temperature for 12 hours. This is a high and low temperature cycle. Each sample to be tested needs to be tested for six cycles to observe its stability.

[0087] The results are shown in Tables 7, 8 and 9.

[0088] "○" in Tables 7 to 9 indicates that the emulsified state is uniform and normal, while "×" indicates that the state is abnormal (oiling, emulsion breaking, particle precipitation, etc.).

[0089] Table 7: 0-day sample test results Table 8: Stability test results Table 9: Stability test results “ / ” means no data.

[0090] in conclusion: (1) Compared with the formulation lacking any one of the natural polymer emulsifier, phospholipid emulsifier and anionic emulsifier, the formulation obtained by using the natural polymer emulsifier, phospholipid emulsifier and anionic emulsifier as emulsifiers at the same time has better appearance and stability of appearance, viscosity and ceramide NP content under conditions such as high temperature, refrigeration (0°C), freezing (-15°C), room temperature, light, high and low temperature cycle, etc., indicating that the natural polymer emulsifier, phospholipid emulsifier and anionic emulsifier provided by the present invention play a synergistic role with each other.

[0091] (2) Compared with other oil-soluble solvents (such as caprylic acid / capric acid triglyceride), the alkyl alcohol solvent (such as octyldodecanol) provided by the present invention is more conducive to improving the appearance and stability of the appearance, viscosity and ceramide NP content of the obtained ceramide NP composition under conditions such as high temperature, refrigeration (0°C), freezing (-15°C), room temperature, light, high and low temperature cycles, etc., and has unexpected technical effects.

[0092] (3) Compared with other natural polymer emulsifiers (such as glyceryl stearate citrate, coconut glucoside or arachidyl glucoside), the natural polymer emulsifier (such as inulin lauryl carbamate) provided by the present invention is more conducive to improving the appearance and stability of the appearance, viscosity and ceramide NP content of the obtained ceramide NP composition under conditions such as high temperature, refrigeration (0°C), freezing (-15°C), room temperature, light, high and low temperature cycles, etc., and has unexpected technical effects.

[0093] (4) Compared with other phospholipid emulsifiers (such as hydrogenated lysolecithin, hydrogenated lecithin or hydroxylated lecithin), the lecithin provided by the present invention is more conducive to improving the appearance and stability of the appearance, viscosity and ceramide NP content of the obtained ceramide NP composition under conditions such as high temperature, refrigeration (0°C), freezing (-15°C), room temperature, light, high and low temperature cycles, etc., and has unexpected technical effects.

[0094] (5) Compared with other thickeners (such as caesalpinia spinosa gum, xanthan gum or hydrogenated xanthan gum), the use of propylene glycol alginate provided by the present invention as a thickener is more conducive to improving the appearance and stability of the appearance, viscosity and ceramide NP content of the obtained ceramide NP composition under conditions such as high temperature, refrigeration (0°C), freezing (-15°C), room temperature, light, high and low temperature cycles, etc., and has unexpected technical effects.

[0095] The method of the present invention has been described through preferred embodiments, and relevant personnel can obviously modify or appropriately change and combine the methods and applications described herein within the content, spirit and scope of the present invention to implement and apply the technology of the present invention. Those skilled in the art can refer to the content of this article and appropriately improve the process parameters. It is particularly important to point out that all similar replacements and modifications are obvious to those skilled in the art, and they are all considered to be included in the present invention.

Claims

1. A composition, characterized in that include: Active ingredients, emulsifiers, thickeners and solvents; The active ingredient is ceramide NP; The emulsifier includes at least one of anionic emulsifier, natural polymer emulsifier, nonionic emulsifier and phospholipid emulsifier; The solvents include water, polyols and oil-soluble solvents.

2. The composition according to claim 1, wherein the thickener is propylene glycol alginate; and / or The anionic emulsifier is sodium stearoyl glutamate; and / or The natural polymer emulsifier is inulin lauryl carbamate; and / or The nonionic emulsifier is polyglyceryl-10 stearate; and / or The phospholipid emulsifier is lecithin.

3. The composition according to any one of claims 1 to 2, wherein the polyol comprises at least one of butylene glycol, propylene glycol and dipropylene glycol; and / or The oil-soluble solvent includes at least one of an alkyl alcohol solvent, triethylhexanoin, caprylic / capric triglyceride, isononyl isononanoate, etc.; and / or The solvent is preferably water, 1,3-butanediol and octyldodecanol.

4. The composition according to any one of claims 1 to 3, wherein the polyol is preferably 1,3-butanediol; and / or The oil-soluble solvent is preferably an alkyl alcohol solvent; more preferably, the oil-soluble solvent is octyl dodecanol; and / or The solvent is preferably water, 1,3-butanediol and octyldodecanol.

5. The composition according to any one of claims 1 to 4, wherein the content of the ceramide NP is 0.010 wt%-2.000 wt% based on the total mass of the composition; and / or The content of the anionic emulsifier is 0.010 wt%-0.400 wt% based on the total mass of the composition; and / or Calculated based on the total mass of the composition, the content of the natural polymer emulsifier is 0.050 wt%-1.000 wt%; and / or The content of the nonionic emulsifier is 0.100wt%-3.000wt% based on the total mass of the composition; and / or Calculated based on the total mass of the composition, the content of the phospholipid emulsifier is 0.010 wt%-0.600 wt%; and / or The content of the thickener is 0.0002 wt%-0.500 wt% based on the total mass of the composition; and / or Calculated based on the total mass of the composition, the content of the polyol is 2.000wt%-12.000wt%; and / or Calculated based on the total mass of the composition, the oil-soluble solvent is an alkyl alcohol solvent, and the content of the alkyl alcohol solvent is 0.200 wt%-7.000 wt%.

6. The composition according to any one of claims 1 to 5, wherein, calculated based on the total mass of the composition, the content of the ceramide NP is 0.010 wt%-2.000wt%, the content of the anionic emulsifier is 0.010 wt%-0.400wt%, the content of the natural polymer emulsifier is 0.050 wt%-1.000wt%, the content of the nonionic emulsifier is 0.100wt%-3.000wt%, the content of the phospholipid emulsifier is 0.010 wt%-0.600wt%, the content of the thickener is 0.0002 wt%-0.500wt%, the content of the polyol is 2.000wt%-5.000wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 0.200 wt%-7.000wt%, and the balance is water; or Calculated based on the total mass of the composition, the content of the ceramide NP is 0.010 wt%, the content of the anionic emulsifier is 0.010 wt%, the content of the nonionic emulsifier is 0.100 wt%, the content of the natural polymer emulsifier is 0.050 wt%, the content of the phospholipid emulsifier is 0.010 wt%, the content of the thickener is 0.0002 wt%, the content of the polyol is 3.500 wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 0.200 wt%, and the balance is water; or Calculated based on the total mass of the composition, the content of the ceramide NP is 2.000wt%, the content of the anionic emulsifier is 0.400wt%, the content of the nonionic emulsifier is 3.000wt%, the content of the natural polymer emulsifier is 1.000wt%, the content of the phospholipid emulsifier is 0.600wt%, the content of the thickener is 0.500wt%, the content of the polyol is 3.500wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 7.000wt%, and the balance is water; or Calculated based on the total mass of the composition, the content of the ceramide NP is 1.000wt%, the content of the anionic emulsifier is 0.300wt%, the content of the nonionic emulsifier is 1.000wt%, the content of the natural polymer emulsifier is 0.500wt%, the content of the phospholipid emulsifier is 0.200wt%, the content of the thickener is 0.300wt%, the content of the polyol is 3.500wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 5.000wt%, and the balance is water; or Calculated based on the total mass of the composition, the content of the ceramide NP is 1.000wt%, the content of the anionic emulsifier is 0.300wt%, the content of the nonionic emulsifier is 1.000wt%, the content of the natural polymer emulsifier is 0.200wt%, the content of the phospholipid emulsifier is 0.200wt%, the content of the thickener is 0.300wt%, the content of the polyol is 3.500wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 5.000wt%, and the balance is water.

7. A method for preparing the composition according to any one of claims 1 to 6, characterized in that: The following steps are involved: Step (1): mixing and dispersing the components in component 2 to obtain a mixed solution of component 2; then mixing and heating the components in component 1 to obtain a mixed solution of component 1, adding the mixed solution of component 2 to the mixed solution of component 1, homogenizing, and defoaming to obtain a mixture A; the component 1 comprises water, an anionic emulsifier, a phospholipid emulsifier, a natural polymer emulsifier, and a part of the formula amount of polyol; the component 2 comprises a thickener and the remaining formula amount of polyol; Step (2): heating and dissolving component 3 to obtain a mixture B; the component 3 comprises a nonionic emulsifier, an active ingredient and an oil-soluble solvent; Step (3): Mixing the mixture A and the mixture B, homogenizing, and defoaming to obtain the composition.

8. The method according to claim 1, wherein the partial amount of polyol in step (1) is three-sevenths to five-sevenths of the amount of polyol, or four-sevenths of the amount of polyol.

9. The method according to any one of claims 7 to 8, wherein the temperature of the heated component 1 in step (1) is 80°C to 90°C; and / or The homogenization speed of the step (1) is 2500 rpm -3500 rpm; and / or The homogenization time in step (1) is 2 minutes to 6 minutes; and / or The defoaming in step (1) is vacuum defoaming; and / or The temperature of heating and dissolving in step (2) is 80°C-95°C; and / or The homogenization speed of the step (3) is 2500 rpm -3500 rpm; and / or The homogenization time in step (3) is 3 minutes to 8 minutes; and / or The defoaming in step (3) is vacuum defoaming.

10. Use of the composition according to any one of claims 1 to 6 or the composition prepared by the method according to any one of claims 7 to 9 in the preparation of cosmetics.

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