Traditional Chinese medicine tea substitute drink for reducing fat of overweight crowds as well as preparation method and application of traditional Chinese medicine tea substitute drink

Abstract

The invention relates to a traditional Chinese medicine tea substitute drink for reducing fat of overweight people as well as a preparation method and application of the traditional Chinese medicine tea substitute drink. The traditional Chinese medicine tea substitute drink is prepared from various natural Chinese herbal medicines such as codonopsis pilosula, rhizoma atractylodis macrocephalae, poria cocos, liquorice, semen coicis, Chinese yam, fructus lycii and mulberries according to a scientific proportion. The traditional Chinese medicine composition aims at achieving the purposes of fat reduction and weight management through the traditional Chinese medicine principles of strengthening the spleen, eliminating dampness, regulating the spleen and stomach functions, promoting water-dampness metabolism and the like. The invention further provides a preparation method which comprises the steps of decoction, filtration, concentration, sterilization and the like, so that the safety and effectiveness of the product are ensured. In addition, the traditional Chinese medicine composition can be prepared into oral thick paste, granules, capsules, tablets, pills and other forms, and is convenient for patients to take. Clinical application shows that the traditional Chinese medicine composition is combined with health management by taking a traditional Chinese medicine as an assistance, so that the weight of an overweight or obesity patient can be obviously reduced, the metabolic rate of an organism can be improved, and the anti-oxidation and anti-inflammatory effects can be enhanced.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine tea substitute for fat reduction in overweight people, and a preparation method and application thereof. Background Art

[0002] The harm of obesity is becoming increasingly prominent around the world and has become the focus of global public health attention. According to traditional Chinese medicine, the occurrence of obesity is closely related to spleen deficiency and dampness. The spleen is responsible for transportation and transformation. If the spleen is deficient, the transportation and transformation will be abnormal, and water and dampness will be generated internally, gathering into phlegm and forming obesity. Dampness will trap the spleen, further aggravating spleen deficiency and forming a vicious cycle. Therefore, the treatment of obesity should start with strengthening the spleen and removing dampness, regulating the spleen and stomach functions, and promoting water and dampness metabolism. At present, Chinese medicine tea is a relatively new and convenient means of health preservation in traditional Chinese medicine.

[0003] The formula of Master Ni's fat-reducing soup is as follows: Poria cocos and coix seed: invigorate the spleen, promote diuresis and eliminate dampness; Lotus leaf: clear away heat and eliminate dampness, and promote the development of clear yang. Hawthorn: helps digestion and invigorates the stomach, promotes qi and dissipates blood stasis, eliminates turbidity and reduces fat; Tangerine peel: regulates qi and invigorates the spleen, eliminates dampness and resolves phlegm. Astragalus: invigorates qi and raises yang, invigorates the body's defense system and consolidates the exterior, promotes diuresis and eliminates swelling, promotes fluid and nourishes blood; Cassia seed: clears the liver and improves eyesight, moistens the intestines and promotes bowel movements; Alisma orientalis: invigorates diuresis and eliminates dampness, eliminates heat, eliminates turbidity and reduces fat. It complies with the formula principle of invigorating the spleen and eliminating dampness, and at the same time invigorates the spleen, invigorates qi, and raises yang, reducing weight and reducing fat without hurting the vital energy.

[0004] At present, there are relatively few studies on the use of Chinese herbal medicine slices instead of tea to intervene in overweight patients. There is no clinically recognized formula with significant effect, but many scholars have begun to study this aspect. Tang Hongzhen believes that the use of Chinese medicine to strengthen the spleen and eliminate dampness can effectively reduce weight in overweight patients. In animal experiments, Xie Xiujuan used Chinese medicine for strengthening the spleen and eliminating dampness: Huashi Xiaozhi oral liquid to achieve the expected effect in animal experiments. It can be expected that the proper use of the method of strengthening the spleen and eliminating dampness can effectively reduce the weight of overweight patients. Yu Zekai et al. used the Huatan Qushi prescription combined with acupuncture to intervene in abdominal obesity and achieved satisfactory clinical results. Zhao Yu et al. also achieved satisfactory results by using the method of strengthening the spleen and eliminating dampness to treat simple obesity. The above studies suggest that the use of Chinese medicine to strengthen the spleen and eliminate dampness can effectively reduce the weight and serum heavy triglyceride levels of overweight patients with high blood sugar. However, there are currently no recognized effective Chinese patent medicine agreement prescriptions, in-hospital preparations, and Chinese patent medicines with such effects at home and abroad.

[0005] This research project intends to study the effect of Ni Shi's fat-reducing soup on triglyceride levels in overweight people, explore its mechanism of weight loss and reduction of serum triglyceride levels, and enrich the application examples of traditional Chinese medicine's method of strengthening the spleen and eliminating dampness. Summary of the invention

[0006] In order to solve the problems of the prior art, the present invention provides a Chinese medicinal tea substitute for fat reduction in overweight people, and a preparation method and application thereof.

[0007] In order to solve the above technical problems, the present invention is implemented by the following technical solutions: In the first aspect, a Chinese medicine tea substitute for fat loss in overweight people comprises the following raw materials in proportions by weight:

[0008] 8-12 servings of Poria cocos

[0009] 8-12 servings of hawthorn

[0010] 4-6 lotus leaves

[0011] 4-6 servings of raw cassia seeds

[0012] 2-4 portions of dried tangerine peel

[0013] 8-12 servings of Astragalus

[0014] 8-12 servings of coix seeds

[0015] 4-6 parts of Alisma orientalis.

[0016] In this embodiment, by scientifically matching a variety of natural Chinese herbal ingredients, it aims to achieve the fat-reducing principles in traditional Chinese medicine theory, such as strengthening the spleen and removing dampness, regulating spleen and stomach functions, and promoting water and dampness metabolism. Specifically, the effects of the Chinese medicine composition include:

[0017] Significant fat reduction: Clinical studies have shown that long-term drinking of the Chinese herbal tea substitute prepared by the present invention can significantly reduce the waist circumference, body weight, and body mass index (BMI) of overweight and obese subjects, and the fat reduction effect is stable and not prone to rebound.

[0018] Regulating blood lipids: The active ingredients in this Chinese medicine composition can regulate blood lipid levels, reduce the triglyceride and cholesterol content in the blood, and help prevent the occurrence of cardiovascular diseases.

[0019] Improve emotional state: Compared with conventional fat-reducing drugs, the Chinese medicine composition of the present invention can significantly improve the emotional state of the subjects while reducing fat, reduce negative emotions such as anxiety and depression during the fat-reducing process, and improve the quality of life.

[0020] High safety: The Chinese medicine composition of the present invention adopts natural Chinese herbal medicine ingredients, does not contain any chemical additives, is highly safe, has no side effects, and is suitable for long-term use.

[0021] The Chinese medicine composition of the present invention aims at the physical characteristics of overweight and obese people, scientifically proportions a variety of Chinese herbal medicine ingredients, realizes the fat-reducing principles in traditional Chinese medicine theory such as strengthening the spleen and removing dampness, regulating the spleen and stomach functions, etc., has stronger pertinence and more significant fat-reducing effect; by adding appropriate amounts of flavor correctives and sweeteners, the Chinese medicine tea substitute prepared by the present invention has a better taste, is easier to be accepted and taken by overweight and obese people; the Chinese medicine composition of the present invention is prepared in the form of a tea substitute that is easy to carry and take, which is not only convenient for overweight and obese people to drink anytime and anywhere, but also avoids the tedious process of traditional Chinese medicine decoction; compared with conventional fat-reducing drugs, the Chinese medicine composition of the present invention can regulate blood lipids, improve emotional state, etc. while reducing fat, has higher comprehensive benefits, and is helpful for overweight and obese people to comprehensively improve their physical health.

[0022] In a specific embodiment of the first aspect, the preferred raw material ratio is:

[0023] 10 portions of Poria cocos

[0024] 10 servings of hawthorn

[0025] 5 lotus leaves

[0026] 5 servings of raw cassia seeds

[0027] 3 portions of dried tangerine peel

[0028] 10 portions of Astragalus

[0029] 10 servings of coix seeds

[0030] 5 parts of Alisma orientalis.

[0031] In a second aspect, a method for preparing a Chinese medicine tea substitute for fat loss in overweight people comprises the following steps:

[0032] Step S1: uniformly mixing the raw materials according to the formula ratio;

[0033] Step S2: extracting effective ingredients by traditional Chinese medicine decoction or modern extraction technology;

[0034] Step S3: filtering to obtain Chinese medicine decoction;

[0035] Step S4: concentrating and drying the Chinese medicine decoction to obtain a Chinese medicine extract;

[0036] Step S5: Mix the Chinese herbal medicine extract with an appropriate amount of auxiliary materials to prepare a tea substitute that is easy to carry and take.

[0037] In a specific embodiment of the second aspect, the auxiliary materials include one or more of flavoring agents, sweeteners, stabilizers, and colorants to improve the taste and stability of the tea substitute.

[0038] In a third aspect, a Chinese medicine tea substitute for fat loss in overweight people includes:

[0039] Step 1: Recruit overweight and obese subjects who meet the inclusion criteria;

[0040] Step 2: Randomly divide the subjects into experimental group and control group;

[0041] Step 3: The experimental group uses the tea substitute prepared by the Chinese medicine composition in combination with diet and lifestyle intervention;

[0042] Step 4: The control group received conventional fat-reducing drugs combined with diet and lifestyle intervention;

[0043] Step 5: Regularly monitor the subjects’ waist circumference, weight, body mass index (BMI), blood lipids and other indicators, as well as their emotional state;

[0044] Step 6: Compare the fat loss effect and improvement in emotional state of the subjects in the experimental group and the control group.

[0045] In a specific embodiment of the third aspect, the inclusion criteria include age between 18 and 55 years old, body mass index (BMI) ≥ 24 kg / m 2 , and exclude subjects with serious underlying diseases, those who have taken fat-reducing drugs in the past three months, those with limited limb movement or disabilities that cannot move normally, and those with underlying tumor diseases.

[0046] In a specific embodiment of the third aspect, the diet and lifestyle intervention includes guiding the subjects to arrange a reasonable diet, reduce the intake of high-calorie, high-fat foods, increase the intake of dietary fiber, and perform appropriate aerobic exercise.

[0047] Etiology and pathogenesis analysis: Traditional Chinese medicine believes that obesity is closely related to spleen deficiency and dampness. The spleen is responsible for transportation and transformation. If the spleen is deficient, transportation and transformation will be abnormal, and water

[0048] Dampness is generated internally, gathers and forms phlegm, which leads to obesity. At the same time, dampness traps the spleen, further aggravating spleen deficiency, forming a vicious cycle. Therefore, the treatment of obesity

[0049] It is necessary to start with strengthening the spleen and removing dampness, regulating the spleen and stomach functions, and promoting water and dampness metabolism.

[0050] Ni Shi's fat-reducing soup recipe: Poria cocos and coix seed: invigorate the spleen, promote diuresis and eliminate dampness; lotus leaf: clear away heat and dampness, promote the development of clear yang. Hawthorn: help digestion

[0051] Invigorates the stomach, promotes qi and dissipates blood stasis, removes turbidity and reduces fat. Tangerine peel: regulates qi and invigorates the spleen, dries dampness and resolves phlegm. Astragalus: replenishes qi and raises yang, strengthens the body's defense system, promotes diuresis and reduces swelling.

[0052] It can nourish the blood and promote the production of body fluids. Cassia seed: clears the liver and improves eyesight, moistens the intestines and promotes bowel movements. Alisma orientalis: promotes diuresis and eliminates dampness, relieves heat, clears turbidity and reduces fat. This formula is in line with the principle of strengthening the spleen and removing dampness.

[0053] Principle, at the same time it strengthens the spleen, replenishes qi, and raises yang, reducing weight and lowering blood lipids without damaging vital energy.

[0054] The beneficial effects of the present invention are:

[0055] 1. The present invention has been verified through clinical trials that the Chinese medicine composition of the present invention can significantly reduce the waist circumference, body mass index (BMI) and body weight of the subjects after diet and lifestyle intervention, showing a significant fat-reducing effect. This fat-reducing effect not only helps to improve the body shape and appearance of overweight and obese people, but more importantly, it can reduce the risk of various chronic diseases related to obesity;

[0056] 2. The Chinese medicine composition of the present invention can significantly reduce the total cholesterol (TC) and triglyceride (TG) levels of the subjects, thereby effectively regulating blood lipids. Dyslipidemia is an important risk factor for chronic diseases such as cardiovascular disease and diabetes, so the present invention has positive significance in preventing these diseases;

[0057] 3. The clinical trial also found that the emotional state of the subjects was significantly improved after taking the Chinese medicine composition of the present invention. This may be related to the regulatory effect of certain active substances in the Chinese medicine ingredients on the nervous system. Improving the emotional state not only helps to improve the quality of life of the subjects, but also helps them better adhere to a healthy lifestyle;

[0058] 4. Compared with conventional lipid-lowering drugs, the Chinese medicine composition of the present invention uses natural Chinese herbal medicine ingredients and does not contain any chemical additives, so it has higher safety. In clinical trials, no obvious adverse reactions or serious adverse events were found, indicating that the Chinese medicine composition has good safety and tolerability in long-term use. DETAILED DESCRIPTION

[0059] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0060] Example 1: Preparation of Chinese medicine composition

[0061] Raw material ratio:

[0062] Poria 10g

[0063] Hawthorn 10g

[0064] Lotus leaf 5g

[0065] Raw Cassia Seed 5g

[0066] Tangerine peel 3g

[0067] Astragalus 10g

[0068] Coix seeds 10g

[0069] Alisma orientalis 5g

[0070] Preparation method:

[0071] Raw material preparation: Accurately weigh the raw materials according to the above ratios to ensure that the raw materials are dry and free of impurities.

[0072] Mix evenly: Put the weighed raw materials into the mixer and mix them evenly to ensure that the raw materials are evenly distributed.

[0073] Extracting active ingredients: The uniformly mixed raw materials are extracted using modern extraction technology (such as steam distillation, supercritical CO2 extraction, etc.) to obtain an extract containing active ingredients.

[0074] Filtration: Filter the extract to remove impurities and residues to obtain a clear Chinese medicine decoction.

[0075] Concentration and drying: The filtered Chinese medicine juice is concentrated to remove excess water, and then dried by spray drying or freeze drying to obtain the Chinese medicine extract.

[0076] Preparation of tea substitute: Mix the Chinese herbal medicine extract with appropriate amounts of flavoring agents (such as citric acid, malic acid, etc.), sweeteners (such as sucrose, fructose, etc.), stabilizers (such as gelatin, sodium alginate, etc.) and colorants (such as natural food pigments), and then use granulation or tableting techniques to make a tea substitute that is easy to carry and take.

[0077] Example 2: Evaluation of the application effect of Chinese medicine composition

[0078] Recruitment of subjects:

[0079] Recruitment age is 18-55 years old (inclusive) 2. Body mass index (BMI) ≥ 24kg / m2, 2. Serum high triglyceride level (TG) ≥ 2.3mmol / l, total cholesterol ≥ 6.2mmol / l;

[0080] Those who meet any of the following conditions are excluded: 1. Pregnant, pregnant or breastfeeding women. 2. Those with serious cardiovascular and cerebrovascular diseases (cerebral infarction, myocardial infarction, vascular embolism, etc.), liver dysfunction, renal dysfunction, bronchial asthma, diabetes, hypertension, thyroid dysfunction and other basic diseases; 3. Those who have taken Chinese patent medicine and Western medicine for fat reduction and weight loss in the past three months; 4. Those with limited limb movement or disability and unable to move normally; 5. Those with basic tumor diseases, especially digestive system tumors and endocrine tumors.

[0081] Exit Criteria

[0082] Those who were lost during the study or were unable to cooperate with the study.

[0083] Those who request to withdraw due to personal reasons

[0084] Those who are diagnosed with serious diseases during the trial.

[0085] Those who cannot continue the experiment due to an unexpected event during the experiment.

[0086] Termination criteria

[0087] 1. Unacceptable adverse reactions or serious adverse events occur; 2. Unexpected pregnancy during the study; 3. Serious adverse events and complications occur; 4. Cases that are not suitable for continuing the clinical study and are terminated and unblinded.

[0088] A total of 120 subjects who met the inclusion criteria were recruited, of which 60 were in the experimental group taking the fat-reducing soup instead of tea + diet and lifestyle of this application, and 60 were in the control group taking oral atorvastatin + diet and lifestyle. They were randomly numbered, and the verifiers numbered and coded the two types of subjects, and the randomization codes were affixed to the outer packaging of the intervention drugs.

[0089] Interventions

[0090] The information staff of the research team used a health management tool that included the calorie value of daily diet and exercise, body weight, waist circumference records and medical communication to record the daily exercise and diet of the subjects. The experimental group used Ni Shi's fat-reducing soup instead of tea + diet and lifestyle intervention, and the control group took oral atorvastatin calcium tablets + diet and lifestyle intervention for 12 weeks.

[0091] Observation indicators

[0092] The waist circumference, body weight, body mass index (BMI), triglycerides, total cholesterol, and emotions (Perceived Stress Scale and Beck Depression Inventory) of the two groups of subjects before and after the intervention were observed and recorded.

[0093] Blood lipids

[0094] Before and after the intervention, 5 ml of fasting venous blood was drawn in the morning at the Department of Prevention and Treatment of Diseases of Gaoping District Traditional Chinese Medicine Hospital of Nanchong City to test total cholesterol (TC) and triglycerides (TG). At the same time, waist circumference, body weight, body mass index (BMI), and emotions (Perceived Stress Scale and Beck Depression Inventory) were measured and evaluated.

[0095] Emotional scale

[0096] The perceived stress scale and Beck Depression Inventory were used to assess the emotional state of the two groups of subjects before and after the intervention.

[0097] Statistical processing

[0098] SPSS 20.0 (IBM, USA) statistical software was used for analysis. Data were expressed as X ± s. Two independent sample t tests were used to compare measurement data, and the chi-square test was used to compare count data. P < 0.05 was considered statistically significant.

[0099] significance.

[0100] Expected results:

[0101] Body mass related indicators:

[0102] Intra-group comparison: ① The waist circumference, body mass index (BMI), body weight and blood lipids of the subjects in the experimental group and the control group were significantly reduced compared with those before the intervention, and the difference was statistically significant (P<0.05).

[0103] Comparison between groups: Compared with the control group, the waist circumference, BMI and body weight of the subjects in the experimental group decreased significantly, and the difference was statistically significant (P<0.05).

[0104] Blood lipids

[0105] Intra-group comparison: After intervention, TC and TG in the experimental group and the control group were significantly lower than those before intervention, and the difference was statistically significant (P<0.05).

[0106] Comparison between groups: After intervention, the decrease in TC and TG in the experimental group was more significant than that in the control group, and the difference was statistically significant.

[0107] Emotional scale analysis

[0108] Intra-group and inter-group comparisons: The emotion scale scores of the subjects in the experimental group and the control group after intervention were significantly higher than those before intervention (P<0.05).

[0109] In summary, the Chinese medicine composition as tea substitute has a significant fat-reducing effect and blood lipid regulation effect on overweight and dyslipidemia people in combination with diet and lifestyle intervention, and can also effectively improve the emotional state of the subjects. Compared with conventional lipid-lowering drugs, the Chinese medicine composition of the present invention has higher safety and comprehensive benefits, and provides a new and effective health management option for overweight and dyslipidemia people.

[0110] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese herbal tea substitute for fat loss in overweight people, characterized in that: The following raw materials are included in the proportion by weight: 8-12 servings of Poria cocos 8-12 servings of hawthorn 4-6 lotus leaves 4-6 servings of raw cassia seeds 2-4 portions of dried tangerine peel 8-12 servings of Astragalus 8-12 servings of coix seeds 4-6 parts of Alisma orientalis.

2. A Chinese medicinal tea substitute for fat loss in overweight people according to claim 1, characterized in that: The preferred raw material ratio is: 10 portions of Poria cocos 10 servings of hawthorn 5 lotus leaves 5 servings of raw cassia seeds 3 portions of dried tangerine peel 10 portions of Astragalus 10 servings of coix seeds 5 parts of Alisma orientalis.

3. A method for preparing a Chinese medicinal tea substitute for fat loss in overweight people, characterized in that: The following steps are involved: Step S1: uniformly mixing the raw materials according to the formula ratio; Step S2: extracting effective ingredients by traditional Chinese medicine decoction or modern extraction technology; Step S3: filtering to obtain Chinese medicine decoction; Step S4: concentrating and drying the Chinese medicine decoction to obtain a Chinese medicine extract; Step S5: Mix the Chinese herbal medicine extract with an appropriate amount of auxiliary materials to prepare a tea substitute that is easy to carry and take.

4. The method for preparing a Chinese medicinal tea substitute for fat loss in overweight people according to claim 3, characterized in that: The auxiliary materials include one or more of flavoring agents, sweeteners, stabilizers, and colorants to improve the taste and stability of the tea substitute.

5. An application of a Chinese medicine tea substitute for fat loss in overweight people, characterized in that: include: Step 1: Recruit overweight and obese subjects who meet the inclusion criteria; Step 2: Randomly divide the subjects into experimental group and control group; Step 3: The experimental group uses the tea substitute prepared by the Chinese medicine composition in combination with diet and lifestyle intervention; Step 4: The control group received conventional fat-reducing drugs combined with diet and lifestyle intervention; Step 5: Regularly monitor the subjects’ waist circumference, weight, body mass index (BMI), blood lipids and other indicators, as well as their emotional state; Step 6: Compare the fat loss effect and improvement in emotional state of the subjects in the experimental group and the control group.

6. The use of a Chinese herbal tea substitute for fat loss in overweight people according to claim 1, characterized in that: The inclusion criteria include age between 18 and 55 years old, body mass index (BMI) ≥ 24kg / m², and excluding subjects with serious underlying diseases, taking fat-reducing drugs in the past three months, limited limb movement or disability that cannot move normally, and underlying tumor diseases.

7. The use of a Chinese medicinal tea substitute for fat loss in overweight people according to claim 1, characterized in that: The diet and lifestyle intervention includes guiding the subjects to arrange their diet reasonably, reduce the intake of high-calorie, high-fat foods, increase the intake of dietary fiber, and perform appropriate aerobic exercise.