Tibetan medicine composition for improving depression and preparation method thereof

Abstract

The invention relates to a Tibetan medicine composition for improving depression. The Tibetan medicine composition is prepared from the following raw materials in parts by weight: 10 to 20 parts of fructus choerospondiatis, 5 to 10 parts of saffron crocus, 10 to 15 parts of clove, 40 to 50 parts of cardamom, 40 to 50 parts of cumin, 12 to 15 parts of piper longum and 20 to 30 parts of fresh yak milk. The invention also relates to a preparation method of the Tibetan medicine composition for improving depression. The preparation method comprises the following steps: S1, decocting fresh yak milk until the fresh yak milk is thick, and cooling to room temperature for later use to obtain yak cream; s2, denucleating saffron crocus, clove and fructus choerospondiatis, respectively grinding into fine powder, and sieving for later use; s3, decocting the other raw materials into paste; and S4, uniformly mixing the paste and the fine powder. The traditional Chinese medicine composition can significantly improve the depression mood and can significantly improve the sleep quality at the same time. The preparation method is simple, the raw materials are fully utilized, and the prepared preparation is remarkable in curative effect and convenient to take.

Description

Technical Field

[0001] The invention relates to the field of medicine, and in particular to a Tibetan medicine composition for improving depression and a preparation method thereof. Background Art

[0002] Depression is a type of mental disorder characterized by depression and mood disorders. It has the characteristics of high prevalence, high disability rate, high recurrence rate and high mortality rate, which brings huge burden and harm to families and society. According to the World Health Organization, more than 298 million people suffer from depression worldwide, and the incidence rate is increasing year by year. It is expected that by 2030, depression will become the second largest burden disease in the world. Data from the China Mental Health Survey show that the number of people suffering from depression is increasing year by year and showing a trend of younger age, becoming the most common chronic mental illness. Although the understanding of depression in all walks of life is becoming more and more in-depth, and the diagnosis rate of the disease is also increasing, the recurrence rate is relatively high and the adverse reactions are more obvious, which increases the burden on individuals, families and society. Current studies have found that the neurocognitive damage of depression is relatively serious and is the biggest factor causing non-fatal health loss because it seriously affects the social function and quality of life of patients. The main method of clinical treatment of this disease is oral antidepressant therapy. Although it has a certain effect, it is taken for a long time and there are adverse reactions to varying degrees in the drugs, which reduces the patient's compliance with treatment. Tibetan medicine has the advantages of multiple targets and few adverse reactions, and plays an important role in improving treatment effects and reducing complications. Therefore, there is an urgent need for a traditional preparation that is drug-free, safe and reliable, has few adverse reactions and has significant antidepressant effects. Summary of the invention

[0003] The purpose of the present invention is to provide a Tibetan medicine composition and a preparation method thereof which can significantly improve symptoms such as depression, irritability, fear, insomnia, dreaminess, slow thinking, etc. The composition can significantly improve sleep quality while improving depression, thereby effectively consolidating the therapeutic effect.

[0004] The technical solution of the present invention:

[0005] A Tibetan medicine composition for improving depression comprises the following raw materials in parts by weight: 10-20 parts by weight of jujube, 5-10 parts by weight of saffron, 10-15 parts by weight of cloves, 40-50 parts by weight of cardamom, 40-50 parts by weight of cumin, 12-15 parts by weight of cymbopogon citratus and 20-30 parts by weight of fresh yak milk.

[0006] Preferably, a Tibetan medicine composition for improving depression comprises the following raw materials in parts by weight: 15 parts by weight of Ziziphus jujuba, 8 parts by weight of saffron, 12 parts by weight of cloves, 45 parts by weight of cardamom, 45 parts by weight of cumin, 12 parts by weight of basil and 25 parts by weight of fresh yak milk.

[0007] Preferably, a Tibetan medicine composition for improving depression comprises the following raw materials in parts by weight: 16 parts by weight of Ziziphus jujuba, 8 parts by weight of saffron, 12 parts by weight of cloves, 46 parts by weight of cardamom, 46 parts by weight of cumin, 13 parts by weight of basil and 24 parts by weight of fresh yak milk.

[0008] Preferably, a Tibetan medicine composition for improving depression comprises the following raw materials in parts by weight: 15 parts by weight of Ziziphus jujuba, 6 parts by weight of saffron, 13 parts by weight of cloves, 45 parts by weight of cardamom, 46 parts by weight of cumin, 15 parts by weight of basil and 27 parts by weight of fresh yak milk.

[0009] Preferably, a method for preparing a Tibetan medicine composition for improving depression comprises the following steps:

[0010] S1. First, boil fresh yak milk until it becomes a paste, cool it to room temperature and then prepare yak milk paste;

[0011] S2, remove the cores of saffron, cloves and jujube, grind them into fine powder and sieve them for later use;

[0012] S3, wash the cardamom, cumin and basil, soak them in pure water for 2 hours after mixing, boil them in boiling water in an evaporator for 2 hours, filter out the juice; add pure water to the residue and continue boiling water for 2 hours, filter out the juice; add pure water to the residue and continue boiling water for 2 hours, filter out the juice; mix the three juices together, boil and concentrate until the volume is 1 / 3 to 1 / 2 of the original volume, pour the concentrated juice into the rice cooker and boil and concentrate on low heat for 4 hours;

[0013] S4. Mix saffron powder, clove powder and jujube powder into the concentrated paste in S3 and stir evenly. Then add yak cream and stir evenly.

[0014] Preferably, the density of the yak cream in S1 is 1.15-1.25 g / cm 3 .

[0015] Preferably, the fine powder in S2 is sieved through a 150-200 mesh sieve.

[0016] Preferably, in S3, the cardamom, cumin and basil are washed twice.

[0017] Preferably, the weight ratio of the sum of the weight of cardamom, cumin and basil in S3 to the pure water for soaking is 92-115:2000;

[0018] The weight of pure water added to the medicinal residue is the same as the weight of pure water used for soaking;

[0019] Medium or low heat is the lowest temperature setting used in rice cookers when cooking porridge or slow cooking.

[0020] Preferably, the room temperature is 4-38°C.

[0021] Theory of the Invention:

[0022] Tibetan medicine believes that the pulse of consciousness is located in the heart. When evil qi invades the heart pulse, it blocks the flow of consciousness, affects the function of the mind, and causes various mental diseases. The brain is the sea of ​​white veins, one of the organs that manages thinking and emotions, and is the basis of psychology. Therefore, the heart and brain are considered to be organs of psychological activities. Depression belongs to the category of "Saulong disease, which is life-preserving Long disease" in Tibetan medicine theory. It is mainly manifested by symptoms such as emotional depression, irritability, fear, insomnia, dreaminess, slow thinking, and night sweats. The main reason for this symptom is that various internal and external factors such as emotional disharmony, restlessness, depression, fright, long-term insomnia, extreme anger and resentment cause the three factors of the body, Long, Tripa, and Bacon, to be disordered, especially the excessive, weak or disordered function of Suolong, which causes the "brain god" and "mind" to malfunction. 10-20 parts by weight of Choerospondias jujuba, 5-10 parts by weight of saffron, 10-15 parts by weight of cloves, 40-50 parts by weight of cardamom, 40-50 parts by weight of cumin, 12-15 parts by weight of Bi Bo and 20-30 parts by weight of fresh yak milk can relieve symptoms such as dullness. The Tibetan medicinal material Choerospondias fasciata introduced by the present invention is shaped like a heart in Tibetan medicine, and has the effects of purging heart fire, relieving heart pain, improving heart blood circulation and depression; saffron has the effects of relieving fever, nourishing blood, strengthening the body and treating liver disease; clove has the effects of calming the nerves and regulating qi, strengthening the spleen and stomach, stopping diarrhea, treating vital pulse disease and lung disease; cardamom has the effects of nourishing the kidney and regulating cold diseases; cumin has the effects of strengthening the stomach and digesting food, treating sorlong disease and lung heat disease; bibo has the effects of calming sorlong, strengthening the stomach, relieving gastrointestinal flatulence, treating cold syndrome and sorlong disease; fresh yak milk has the effects of nourishing qi and blood, calming sorlong and strengthening the body.

[0023] Fructus Atractylodes: neutral in nature, sweet and sour in taste. No meridians are currently available. Neutral in nature, sweet and sour in taste. No meridians are currently available. Used to treat qi stagnation and blood stasis, chest pain, palpitations, shortness of breath, and restlessness. Contains flavonoids, phenolic acid compounds, amino acids and other ingredients. The active ingredient, total flavonoids, has anti-hypoxia and protective effects on acute myocardial ischemia, and has significant anti-arrhythmia, anti-platelet aggregation and immune enhancement effects in various animal models.

[0024] Saffron: sweet, mild, non-toxic. "Main treatment" for depression, suffocation, blood circulation. Long-term use makes people happy. Also treats palpitations (Shizhen).

[0025] Clove: spicy, warm in nature. It enters the stomach meridian, spleen meridian, and kidney meridian. It warms the middle and lowers adverse symptoms, nourishes the kidney and helps yang. It is a warm medicine. It warms the middle and lowers adverse symptoms, nourishes the kidney and helps yang. It is a warm medicine. It warms the middle and lowers adverse symptoms, nourishes the kidney and helps yang. It is a warm medicine. Clove has the effects and functions of anti-gastric ulcer, anti-diarrhea, gallbladder, analgesia, anti-hypoxia, anti-coagulation, anti-mutation, antibacterial and insecticidal. Clove also has the effect and function of strengthening the stomach. The extract has a significant effect of stimulating gastric juice secretion and can relieve abdominal distension, nausea, vomiting, etc. In addition, clove has an inhibitory effect on a variety of pathogenic fungi, cocci, streptococci, pneumonia, dysentery, large intestine, typhoid and other bacilli, as well as influenza viruses. It contains 15% to 20% volatile oil, and the main components of the oil are eugenol, β-caryophyllene, acetyl eugenol, etc. It also contains eugenol, acetyl eugenol, isoquercetin, kaempferol, quercetin, caryophyllene oxide, oleanolic acid, α-ylang-ylangolene and other ingredients.

[0026] Cardamom: It can dissipate dampness and promote qi, warm the middle and stop vomiting, stimulate appetite and help digestion. It is used to treat dampness and turbidity blocking the middle, loss of appetite, initial onset of damp-heat, chest tightness without hunger, cold-damp vomiting, chest and abdominal distension and pain, and indigestion. Cardamom contains volatile oil, a small amount of saponin, pigment and starch. The main components of volatile oil are d-camphor and eucalyptol cymene. It is used as a digestive and wind-expelling agent and aromatic stimulant.

[0027] Cumin: (seeds) are often used to treat indigestion, stomach cold and abdominal pain.

[0028] Bi Bo: Very spicy and hot, similar to pepper in taste, enters the stomach and large intestine, and is a Yangming medicine. It warms the middle and dispels cold, breaks stagnant qi, relieves depression, removes phlegm, and can also disperse the floating heat in the upper part of the body. All toothaches, headaches, acid regurgitation and other symptoms that belong to Yangming damp fire can be treated with this. The fruit contains piperine, palmitic acid, tetrahydropiperidinic acid, volatile oil, etc. The unsaponifiable matter of volatile oil can reduce exogenous and endogenous total cholesterol in animals; volatile oil can counteract hypoxia and myocardial ischemia caused by various conditions; correct experimental arrhythmias in animals; and has sedative, analgesic, and antipyretic effects.

[0029] Beneficial effects of the present invention:

[0030] The Tibetan medicine composition can significantly improve depression and improve sleep quality.

[0031] The preparation method of the Tibetan medicine composition is simple, the raw materials are fully utilized, the prepared preparation has significant curative effect and is easy to take.

[0032] The dosage and usage of the present invention are as follows: 1-2 times a day, 10-20 g each time, mixed in hot milk and taken. DETAILED DESCRIPTION

[0033] Composition Example 1

[0034] A Tibetan medicine composition for improving depression comprises the following raw materials by weight: 15g of jujube, 8g of saffron, 12g of cloves, 45g of cardamom, 45g of cumin, 12g of cymbopogon citratus and 25g of fresh yak milk.

[0035] Composition Example 2

[0036] A Tibetan medicine composition for improving depression comprises the following raw materials by weight: 16g of jujube, 8g of saffron, 12g of cloves, 46g of cardamom, 46g of cumin, 13g of cymbopogon citratus and 24g of fresh yak milk.

[0037] Composition Example 3

[0038] A Tibetan medicine composition for improving depression comprises the following raw materials by weight: 15g of jujube, 6g of saffron, 13g of cloves, 45g of cardamom, 46g of cumin, 15g of basil and 27g of fresh yak milk.

[0039] Composition Example 4

[0040] A Tibetan medicine composition for improving depression comprises the following raw materials by weight: 10 g of jujube, 10 g of saffron, 10 g of clove, 40 g of cardamom, 50 g of cumin, 12 g of basil and 30 g of fresh yak milk.

[0041] Composition Example 5

[0042] A Tibetan medicine composition for improving depression comprises the following raw materials by weight: 20g of jujube, 5g of saffron, 15g of clove, 50g of cardamom, 40g of cumin, 15g of basil and 20g of fresh yak milk.

[0043] Method Example 1

[0044] A method for preparing a Tibetan medicine composition for improving depression comprises the following steps:

[0045] S1. First, boil fresh yak milk until it is in a paste form and cool it to room temperature for later use to obtain yak cream. The density of yak cream is 1.15 g / cm 3 ;

[0046] S2, remove the cores of saffron, cloves and jujube, grind them into fine powder and pass through a 200 sieve for later use;

[0047] S3, cardamom, cumin and bipo are washed twice, mixed and soaked in pure water for 2 hours, the weight ratio of the sum of the weight of cardamom, cumin and bipo to the pure water for soaking is 100:2000, and after soaking, they are boiled in an evaporator for 2 hours, and the juice is filtered out; pure water with the same weight as the pure water for soaking is added to the medicinal residues, and the boiling water is continued for 2 hours, and the juice is filtered out; pure water with the same weight as the pure water for soaking is added to the medicinal residues, and the boiling water is continued for 2 hours, and the juice is filtered out; the three juices are mixed together, boiled and concentrated to 1 / 2 of the original volume, and the concentrated juice is poured into the rice cooker and boiled and concentrated on low heat for 4 hours;

[0048] S4. Mix saffron powder, clove powder and jujube powder into the concentrated paste in S3 and stir evenly. Then add yak cream and stir evenly.

[0049] Method Example 2

[0050] A method for preparing a Tibetan medicine composition for improving depression comprises the following steps:

[0051] S1. First, boil fresh yak milk until it is paste-like and cool it to room temperature for later use to obtain yak cream. The viscosity of yak cream is 1.20g / cm 3 ;

[0052] S2, remove the cores of saffron, cloves and jujube, grind them into fine powder and pass through a 200 sieve for later use;

[0053] S3, cardamom, cumin and bipo are washed twice, mixed and soaked in pure water for 2 hours, the weight ratio of the sum of the weight of cardamom, cumin and bipo to the pure water for soaking is 92:2000, and after soaking, they are boiled in an evaporator for 2 hours, and the juice is filtered out; pure water with the same weight as the pure water for soaking is added to the medicinal residues, and the boiling water is continued for 2 hours, and the juice is filtered out; pure water with the same weight as the pure water for soaking is added to the medicinal residues, and the boiling water is continued for 2 hours, and the juice is filtered out; the three juices are mixed together, boiled and concentrated to 1 / 3 of the original volume, and the concentrated juice is poured into the rice cooker and boiled and concentrated on low heat for 4 hours;

[0054] S4. Mix saffron powder, clove powder and jujube powder into the concentrated paste in S3 and stir evenly. Then add yak cream and stir evenly.

[0055] Method Example 3

[0056] A method for preparing a Tibetan medicine composition for improving depression comprises the following steps:

[0057] S1. First, boil fresh yak milk until it is in a paste form and cool it to room temperature for later use to obtain yak cream. The density of yak cream is 1.25g / cm 3 ;

[0058] S2, remove the cores of saffron, cloves and jujube, grind them into fine powder and pass through a 150 sieve for later use;

[0059] S3, cardamom, cumin and basil were washed twice, mixed and soaked in pure water for 2 hours, the weight ratio of the sum of the weight of cardamom, cumin and basil to the pure water for soaking was 115:2000, and after soaking, they were boiled in an evaporator for 2 hours, and the juice was filtered out; pure water with the same weight as the pure water for soaking was added to the medicinal residues, and the boiling water was continued for 2 hours, and the juice was filtered out; pure water with the same weight as the pure water for soaking was added to the medicinal residues, and the boiling water was continued for 2 hours, and the juice was filtered out; the three juices were mixed together, boiled and concentrated to 5 / 12 of the original volume, and the concentrated juice was poured into the rice cooker and boiled and concentrated on low heat for 4 hours;

[0060] S4. Mix saffron powder, clove powder and jujube powder into the concentrated paste in S3 and stir evenly. Then add yak cream and stir evenly.

[0061] Composition Examples 1-2 were prepared using Method Example 1, Composition Examples 3-4 were prepared using Method Example 2, and Composition Example 5 was prepared using Method Example 3.

[0062] Case

[0063] 1. Materials and methods

[0064] 1.1 General data A total of 30 inpatients and outpatients in the Department of Mental Diseases of Qinghai Tibetan Hospital from September 2024 to January 2025 were selected, including 21 males and 9 females. The oldest was 77 years old, the youngest was 22 years old, and the average age was 44.71±11.36 years old. All personnel voluntarily participated and signed informed consent.

[0065] 1.2 Inclusion and Exclusion Criteria

[0066] Inclusion criteria: Meet the clinical diagnostic criteria for depression in the ICD-11 criteria; Hamilton Depression Rating Scale (HAMD-17) score > 7 points; Pittsburgh Sleep Quality Index (PSQI) score > 5 points;

[0067] Exclusion criteria: 1. Patients with major organ dysfunction; 2. Patients with suicidal or self-harming tendencies; 3. Patients who have recently taken antidepressants; 4. Patients who are unable to communicate normally and have poor compliance; 5. Patients with other serious mental illnesses.

[0068] 1.3 Methods

[0069] Method of administration: The composition of Example 1 prepared in Example 1 is taken once a day, 10-20 grams each time mixed in hot milk for 3 weeks.

[0070] 1.4 Observation indicators

[0071] Hamilton Depression Rating Scale (HAMD-17) scores and Pittsburgh Sleep Quality Index (PSQI) scores were measured before and after treatment.

[0072] 1.5 Efficacy evaluation criteria

[0073] According to the efficacy evaluation criteria of "Chinese Medicine Disease Efficacy Diagnosis and Efficacy Standards ZY / T001.1-94-Depression":

[0074] Cured: symptoms disappear and emotions return to normal;

[0075] Improvement: Symptoms are alleviated and emotions are basically stable;

[0076] Uncured: No improvement in symptoms or mood.

[0077] 1.6 Statistical methods

[0078] SPSS 17.0 statistical software was used for analysis. The t test was used for comparison between groups, and analysis of variance was used for comparison of different time periods before and after treatment in the same group. 2 The Kruskal-Wallis H test was used for significance test, and P < 0.05 was considered statistically significant.

[0079] 2. Results and Analysis

[0080] 2.1 Table-1 Clinical results (examples)

[0081] Number of Examples cure Improvement invalid 30 20 5 5

[0082] According to Table 1, among the 30 cases implemented, a large number of patients were cured by the preparation, while a small number were ineffective, indicating that taking the preparation can significantly improve depression, sleep quality and related physical symptoms.

[0083] 2.2 Table-2 Clinical Results

[0084] Table-2 Comparison of HAMD scores and PSQI scores before and after treatment

[0085]

[0086] As shown in Table 2, by comparing the Hamilton Depression Rating Scale scores and the Pittsburgh Sleep Quality Index scores before and after treatment, the HAMD scores and PSQI scores were significantly lower after 3 weeks of treatment than before treatment, and the difference between before and after treatment was statistically significant (p<0.001), indicating that the preparation can significantly improve depression and improve sleep quality.

[0087] The above description is only used to introduce the specific implementation methods of the present invention in detail, but the technical solution proposed by the present invention is not limited to the above method. Without departing from the basic principles of the present technology, equivalent modifications and changes made by those skilled in the art to the technology proposed by the present invention should be included in the scope of the claims of the present invention.

Claims

1. A Tibetan medicine composition for improving depression, characterized in that: The invention comprises the following raw materials in parts by weight: 10-20 parts by weight of jujube, 5-10 parts by weight of saffron, 10-15 parts by weight of cloves, 40-50 parts by weight of cardamom, 40-50 parts by weight of cumin, 12-15 parts by weight of basil and 20-30 parts by weight of fresh yak milk.

2. A Tibetan medicine composition for improving depression according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 15 parts by weight of jujube, 8 parts by weight of saffron, 12 parts by weight of cloves, 45 parts by weight of cardamom, 45 parts by weight of cumin, 12 parts by weight of basil and 25 parts by weight of fresh yak milk.

3. A Tibetan medicine composition for improving depression according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 16 parts by weight of jujube, 8 parts by weight of saffron, 12 parts by weight of cloves, 46 parts by weight of cardamom, 46 parts by weight of cumin, 13 parts by weight of basil and 24 parts by weight of fresh yak milk.

4. A Tibetan medicine composition for improving depression according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 15 parts by weight of jujube, 6 parts by weight of saffron, 13 parts by weight of cloves, 45 parts by weight of cardamom, 46 parts by weight of cumin, 15 parts by weight of basil and 27 parts by weight of fresh yak milk.

5. A method for preparing a Tibetan medicine composition for improving depression according to any one of claims 1 to 4, characterized in that: The following steps are involved: S1. First, boil fresh yak milk until it becomes a paste, cool it to room temperature and then prepare yak milk paste; S2, remove the cores of saffron, cloves and jujube, grind them into fine powder and sieve them for later use; S3, wash the cardamom, cumin and basil, soak them in pure water for 2 hours after mixing, boil them in boiling water in an evaporator for 2 hours, filter out the juice; add pure water to the residue and continue boiling water for 2 hours, filter out the juice; add pure water to the residue and continue boiling water for 2 hours, filter out the juice; mix the three juices together, boil and concentrate until the volume is 1 / 3 to 1 / 2 of the original volume, and then boil the concentrated juice on medium and low heat for 4 hours; S4. Mix saffron powder, clove powder and jujube powder into the concentrated paste in S3 and stir evenly. Then add yak cream and stir evenly.

6. The method for preparing a Tibetan medicine composition for improving depression according to claim 5, characterized in that: The density of yak cream in S1 is 1.15-1.25 g / cm3.

7. The method for preparing a Tibetan medicine composition for improving depression according to claim 5, characterized in that: The fine powder in S2 is passed through a 150-200 mesh sieve.

8. The method for preparing a Tibetan medicine composition for improving depression according to claim 5, characterized in that: In S3, wash the cardamom, cumin and celery twice.

9. The method for preparing a Tibetan medicine composition for improving depression according to claim 5, characterized in that: In S3, the weight ratio of the sum of the weight of cardamom, cumin and celery to the pure water used for soaking is 92-115:2000; the weight of the pure water added to the medicinal residue is the same as the weight of the pure water used for soaking; medium or low heat is the lowest temperature used in the rice cooker when cooking porridge or slow stewing.

10. The method for preparing a Tibetan medicine composition for improving depression according to claim 5, characterized in that: The room temperature is 4-38°C.

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