Traditional Chinese medicine composition for treating oral lichen planus, traditional Chinese medicine decoction-free granules and application

Abstract

The invention discloses a traditional Chinese medicine composition for treating oral lichen planus, traditional Chinese medicine decoction-free granules and application. The traditional Chinese medicine composition comprises 8-10 parts of pogostemon cablin, 6-8 parts of cortex dictamni, 6-10 parts of radix paeoniae alba, 8-10 parts of semen coicis, 6-10 parts of pericarpium citri reticulatae, 6-10 parts of radix curcumae, 6-10 parts of caulis spatholobi, 2-5 parts of coptis chinensis, 7-10 parts of talc, 10-12 parts of dandelion and 5-8 parts of liquorice. The traditional Chinese medicine decoction-free granules comprise the single traditional Chinese medicine formula granules in parts by weight, and the traditional Chinese medicine decoction-free granules are mainly used for soothing the liver, strengthening the spleen and promoting diuresis and are supplemented by regulating qi and promoting blood circulation, so that liver depression is dredged, qi activity is regulated, blood vessels are dredged, the spleen is strengthened, and water dampness is normally transferred, transformed and distributed, and the aim of treating the liver depression, spleen deficiency and dampness winning type oral lichen planus is achieved.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for treating oral lichen planus, a traditional Chinese medicine decoction-free granule and applications thereof. Background Art

[0002] Oral lichen planus is a common chronic oral mucosal skin disease, which is generally not contagious. Its onset is related to mental factors (such as fatigue, anxiety, tension), immune factors, endocrine factors, infection factors, microcirculatory disorders, trace element deficiencies, and certain systemic diseases (diabetes, infection, hypertension, digestive tract dysfunction). Certain drugs such as methyldopa, adipine, chloroquine, aminobenzazole, captopril, quinidine, etc., as well as taking certain Chinese medicines, or when there are metal fillings or restorations in the mouth, changes similar to lichen planus may occur in the mouth, or the original lichen planus lesions may be aggravated. After stopping the use of suspected drugs or replacing fillings and restorations, the lesions are significantly reduced or disappear.

[0003] The pathophysiological manifestations of oral lichen planus are: incomplete keratinization of the epithelium, liquefaction degeneration of basal cells, and dense lymphocyte infiltration bands in the lamina propria. The granular layer is obvious, and the spinous layer is mostly thickened, while a few are atrophic and thin. The epithelial spikes are irregularly extended, and the lower ends sometimes become pointed and serrated. The basal cells are disorderly arranged, and the boundaries of the basement membrane are unclear. Subepithelial blisters may form in those with obvious liquefaction degeneration of basal cells. Eosinophilic red-stained colloid bodies can be seen in the spinous layer, basal layer or lamina propria. Oral lichen planus is often classified as atrophic, reticular, and erosive. The atrophic type is more common on the dorsum of the tongue and is a slightly bluish white plaque. , slightly concave, the lingual papilla atrophy causes the lesion surface to be smooth. When it occurs in the gums, there is congestion or superficial erosion, and white patterns can be seen nearby; the reticular type is a linear white or grayish-white pattern connected by small papules. The patterns can be composed of various shapes such as reticular, dendritic, annular or semi-annular, and can also appear as white patches. It can occur in any part of the oral mucosa, most commonly in the cheeks, and most of them are symmetrical on the left and right; the erosive type often causes erosion on the basis of congestion, so it is also called the congestive erosive type. There are white patterns or papules around the erosions, and the pain is obvious. It often occurs in the cheeks, lips, vestibule grooves, retromolar area, and tongue belly.

[0004] In traditional Chinese medicine theory, oral lichen planus belongs to the category of "mouth sores" and "oral erosions". Its onset is closely related to liver depression and spleen deficiency, internal victory of dampness, and emotional distress. The Western medicine treatment of oral lichen planus usually has problems such as a single target, possible obvious side effects, and only focusing on eliminating symptoms without paying attention to prevention and rehabilitation. Summary of the invention

[0005] In view of the problems of the prior art, the present invention proposes a Chinese medicine composition, a Chinese medicine decoction-free granule and an application thereof for treating oral lichen planus. The Chinese medicine composition and the Chinese medicine decoction-free granule are mainly used for soothing the liver, strengthening the spleen and removing dampness, and are supplemented by regulating qi and activating blood circulation, so that liver depression can be relieved, qi can be regulated and blood vessels can be unblocked, spleen function can be strengthened, and water and dampness can be normally transported, transformed and distributed, thereby achieving the purpose of treating oral lichen planus of liver depression, spleen deficiency and dampness predominance type. The whole formula has rigorous compatibility, and the monarch, minister, assistant and envoy perform their respective functions. The effects of soothing the liver, strengthening the spleen, removing dampness, activating blood circulation and clearing heat complement each other. It not only targets the main pathogenesis of soothing the liver, strengthening the spleen and removing dampness, but also takes into account the pathological changes of blood stasis and stagnation of heat, reflecting the holistic concept and the principle of syndrome differentiation and treatment in the treatment of oral lichen planus in traditional Chinese medicine.

[0006] The present invention provides the following scheme, a Chinese medicine composition for treating oral lichen planus, wherein the Chinese medicine composition comprises the following raw materials in parts by weight: 8-10 parts of patchouli, 6-8 parts of dittany, 6-10 parts of white peony root, 8-10 parts of coix seed, 6-10 parts of tangerine peel, 6-10 parts of turmeric, 6-10 parts of millettia reticulata, 2-5 parts of coptis root, 7-10 parts of talc, 10-12 parts of dandelion, and 5-8 parts of liquorice.

[0007] The Chinese medicine composition for treating oral lichen planus according to the present invention has the following beneficial effects: 1. Overall conditioning: Western medicine often treats local symptoms or a single cause of disease. The Chinese medicine composition provided by the present invention is based on the overall concept of traditional Chinese medicine, starting from the human body as a whole, considering the patient's constitution, viscera function and other factors, and improving the overall internal environment by regulating the body's yin and yang balance, qi and blood circulation and viscera function to achieve the purpose of treatment. It not only eliminates local symptoms, but also adjusts the body's internal state such as dampness and heat to reduce the possibility of recurrence.

[0008] 2. Multi-target action: Western medicine usually acts on a single target. The Chinese medicine composition provided by the present invention contains multiple Chinese medicine ingredients, which can act on multiple pathological links and targets. When treating related diseases, multiple ingredients simultaneously play a role in multiple aspects such as inflammatory response, immune regulation, and cell metabolism, and work synergistically to improve the condition more comprehensively.

[0009] 3. Relatively small side effects: Some Western medicines may have obvious side effects during the treatment process. For example, long-term use of hormone drugs may lead to endocrine disorders and other problems. The Chinese medicine composition provided by the present invention is composed of natural Chinese medicines. Under the condition of reasonable use of the medicines, the side effects are relatively few.

[0010] 4. Personalized treatment: Western medicine often adopts standardized treatment plans, while the Chinese medicine composition provided by the present invention is based on syndrome differentiation and treatment according to the patient's specific symptoms, signs, tongue, pulse, etc., and the drug composition and dosage of the prescription are flexibly adjusted to achieve personalized treatment, which is better adapted to the conditions and physical requirements of different patients.

[0011] 5. Focus on prevention and rehabilitation: Western medicine treatment is mainly to eliminate symptoms. The Chinese medicine composition provided by the present invention can not only treat diseases, but also focus on disease prevention and rehabilitation conditioning. After disease treatment, the conditioning of Chinese medicine can enhance the patient's physical fitness, improve the body's resistance and repair ability, promote physical recovery, prevent disease recurrence, and help patients return to a better health state; 6. Significant therapeutic effect: The Chinese medicine composition provided by the present invention mainly focuses on soothing the liver, invigorating the spleen and eliminating dampness, supplemented by regulating qi and activating blood circulation, so that liver depression can be relieved, qi can be regulated and blood vessels can be unblocked, spleen can be strengthened, and water and dampness can be normally transported and distributed, thereby achieving the purpose of treating oral lichen planus of liver depression, spleen deficiency and dampness predominance type. The whole formula is rigorously compatible, and the monarch, minister, assistant and envoy perform their respective functions. The effects of soothing the liver, invigorating the spleen, eliminating dampness, activating blood circulation and clearing away heat complement each other. It not only targets the main pathogenesis of soothing the liver, invigorating the spleen and eliminating dampness, but also takes into account the pathological changes of blood stasis and stagnation of heat, embodies the holistic concept and principle of syndrome differentiation and treatment of traditional Chinese medicine in the treatment of oral lichen planus, pays attention to the mutual compatibility between drugs and the relationship between the internal organs, and has significant therapeutic effect.

[0012] In addition, the Chinese medicine composition for treating oral lichen planus provided by the present invention may also have the following additional technical features: Preferably, the Chinese medicine composition comprises the following raw materials in parts by weight: 10 parts of patchouli, 8 parts of dittany, 10 parts of white peony root, 10 parts of coix seed, 6 parts of dried orange peel, 6 parts of curcuma, 8 parts of millettia, 2 parts of coptis, 10 parts of talc, 10 parts of dandelion, and 6 parts of liquorice.

[0013] The present invention also provides an application of the above-mentioned traditional Chinese medicine composition for treating oral lichen planus in preparing a medicine for treating oral lichen planus.

[0014] The present invention also provides a decoction-free Chinese medicine granule for treating oral lichen planus, wherein the decoction-free Chinese medicine granule comprises the following single Chinese medicine formula granules in parts by weight: 8-10 parts of patchouli, 6-8 parts of dittany, 6-10 parts of white peony root, 8-10 parts of coix seed, 6-10 parts of tangerine peel, 6-10 parts of turmeric, 6-10 parts of millettia reticulata, 2-5 parts of coptis root, 7-10 parts of talc, 10-12 parts of dandelion, and 5-8 parts of liquorice.

[0015] In addition, the Chinese medicine decoction-free granules for treating oral lichen planus provided by the present invention may also have the following additional technical features: Preferably, the Chinese medicine decoction-free granules include the following single Chinese medicine formula granules in parts by weight: 10 parts of patchouli, 8 parts of dittany, 10 parts of white peony root, 10 parts of coix seed, 6 parts of dried orange peel, 6 parts of curcuma, 8 parts of millettia, 2 parts of coptis, 10 parts of talc, 10 parts of dandelion, and 6 parts of liquorice.

[0016] The present invention also provides an application of the above-mentioned traditional Chinese medicine decoction-free granules for treating oral lichen planus in preparing a medicine for treating oral lichen planus.

[0017] The present invention aims at the pathology of oral lichen planus and adopts a treatment method of soothing the liver, strengthening the spleen, removing dampness, activating blood circulation and clearing away heat. The Chinese medicine treatment mechanism of the present invention is as follows: The main ingredients are Dictamni Cortex and Patchouli. Dictamni Cortex is bitter, cold and clears away heat, and is good at removing dampness and detoxifying. Patchouli is pungent, warm and can relieve exterior symptoms, and is good at removing dampness and harmonizing the middle. At the same time, it can enrich the spleen and restore the qi of the spleen and stomach. The two are complementary to each other, one cold and one warm, and together they can play a role in removing dampness while not forgetting to strengthen the spleen, preventing the return of dampness due to spleen deficiency and dysfunction.

[0018] White peony root, coix seed and tangerine peel are used as ministers. White peony root is slightly cold and sour in taste. It can restrain liver yin, nourish blood and soften the liver. Together with patchouli, it can prevent liver depression from invading the spleen by softening the liver, and strengthen the spleen-strengthening effect of patchouli. Coix seed is cool in nature and sweet in taste. It has the effects of diuretic and dampness-injecting, spleen-strengthening and diarrhea-stopping, and numbness-removing and pus-discharging. It can not only strengthen the dampness-removing function of Dictamni and Patchouli, but also play the role of strengthening the spleen together with patchouli. Tangerine peel is warm in nature and pungent and bitter in taste. It is good at soothing the liver, strengthening the spleen and regulating qi. When the liver is soothed, qi flows, and when qi flows, dampness is removed, and when dampness is removed, moss disappears.

[0019] With turmeric, Millettia reticulata, Coptis chinensis, dandelion and talcum powder as adjuvants, turmeric powder is cold in nature, pungent and bitter in taste, and has the effects of promoting qi and relieving depression, promoting blood circulation and relieving pain, and can enhance the effects of white peony root on soothing the liver and regulating qi, nourishing blood and activating blood circulation. Millettia reticulata is warm, bitter and sweet in nature, and has the functions of activating blood circulation and nourishing blood. It is used together with turmeric powder to enhance the blood circulation and pain-relieving effect of the prescription. Oral lichen planus is prone to depression and heat after long-term illness. Coptis chinensis is a bitter and cold medicine, and dandelion is a sweet and cold medicine. Both have the effects of clearing heat and detoxifying. Together with Dictamni cortex, they enhance the heat-clearing effect of the main medicine. Talcum powder is cold in nature, sweet and light in taste, and its effect of clearing heat and promoting diuresis helps to eliminate damp heat through urination, so that dampness and heat evils have a way out.

[0020] Licorice is used as the messenger. Licorice is sweet and mild in nature. It can harmonize various medicines, alleviate their properties, and reduce possible adverse reactions.

[0021] At the same time, the single-ingredient Chinese medicine formula granules used in the Chinese medicine decoction-free granules proposed in the present invention are a series of pure Chinese medicine products that are extracted, concentrated, separated, dried, granulated and packaged with modern pharmaceutical technology using traditional Chinese medicine pieces that meet processing specifications as raw materials.

[0022] Additional aspects and advantages of the present invention will be given in part in the following description and in part will be obvious from the following description, or will be learned through practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0024] Figure 1 A comparison chart of patient 1 before and after treatment provided by an embodiment of the present invention; Figure 2 A comparison chart of patient 2 before and after treatment provided by an embodiment of the present invention; Figure 3 A comparison chart of patient 3 before and after treatment provided by an embodiment of the present invention; Figure 4 A comparison chart of patient 4 before and after treatment provided by an embodiment of the present invention; Figure 5 This is a comparison chart before and after treatment of patient 5 provided in an embodiment of the present invention.

[0025] The embodiments of the present invention will be further described below with reference to the accompanying drawings. DETAILED DESCRIPTION

[0026] In order to make the purpose, features and advantages of the present invention more obvious and easy to understand, the specific embodiments of the present invention are described in detail below in conjunction with the examples. Several embodiments of the present invention are given in the examples. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present invention more thorough and comprehensive.

[0027] Example 1 In Example 1 of the present invention, a traditional Chinese medicine composition for treating oral lichen planus is provided, which comprises the following raw materials in parts by weight: 10 parts of patchouli, 8 parts of dittany, 10 parts of white peony root, 10 parts of coix seed, 6 parts of tangerine peel, 6 parts of curcuma, 8 parts of millettia reticulata, 2 parts of coptis root, 10 parts of talc, 10 parts of dandelion, and 6 parts of licorice.

[0028] Example 2 In Example 2 of the present invention, a traditional Chinese medicine composition for treating oral lichen planus is provided, which comprises the following raw materials in parts by weight: 10 parts of patchouli, 8 parts of licorice, 8 parts of white peony root, 8 parts of coix seed, 6 parts of tangerine peel, 10 parts of curcuma, 8 parts of millettia reticulata, 2 parts of coptis root, 8 parts of talc, 12 parts of dandelion, and 6 parts of licorice.

[0029] Example 3 In Example 3 of the present invention, a traditional Chinese medicine composition for treating oral lichen planus is provided, which comprises the following raw materials in parts by weight: 10 parts of patchouli, 6 parts of licorice, 10 parts of white peony root, 10 parts of coix seed, 6 parts of tangerine peel, 10 parts of curcuma, 6 parts of millettia reticulata, 2 parts of coptis root, 7 parts of talc, 12 parts of dandelion, and 6 parts of licorice.

[0030] Example 4 In Example 4 of the present invention, a traditional Chinese medicine composition for treating oral lichen planus is provided, which comprises the following raw materials in parts by weight: 10 parts of patchouli, 6 parts of licorice, 10 parts of white peony root, 8 parts of coix seed, 10 parts of tangerine peel, 10 parts of curcuma, 10 parts of millettia reticulata, 2 parts of coptis root, 7 parts of talc, 10 parts of dandelion, and 6 parts of licorice.

[0031] Example 5 In Example 5 of the present invention, a traditional Chinese medicine composition for treating oral lichen planus is provided, which comprises the following raw materials in parts by weight: 10 parts of patchouli, 8 parts of licorice, 6 parts of white peony root, 8 parts of coix seed, 6 parts of tangerine peel, 6 parts of curcuma, 8 parts of millettia reticulata, 5 parts of coptis root, 8 parts of talc, 12 parts of dandelion, and 6 parts of licorice.

[0032] Example 6 In Example 6 of the present invention, a traditional Chinese medicine composition for treating oral lichen planus is provided, which comprises the following raw materials in parts by weight: 10 parts of patchouli, 8 parts of licorice, 6 parts of white peony root, 10 parts of coix seed, 6 parts of tangerine peel, 6 parts of curcuma, 8 parts of millettia reticulata, 2 parts of coptis root, 8 parts of talc, 12 parts of dandelion, and 5 parts of licorice.

[0033] Example 7 In Example 7 of the present invention, a traditional Chinese medicine composition for treating oral lichen planus is provided, which comprises the following raw materials in parts by weight: 8 parts of patchouli, 8 parts of licorice, 8 parts of white peony root, 10 parts of coix seed, 6 parts of tangerine peel, 8 parts of curcuma, 8 parts of millettia reticulata, 2 parts of coptis root, 8 parts of talc, 12 parts of dandelion, and 8 parts of licorice.

[0034] Example 8 In Example 8 of the present invention, a traditional Chinese medicine composition for treating oral lichen planus is provided, which comprises the following raw materials in parts by weight: 10 parts of patchouli, 8 parts of dittany, 10 parts of white peony root, 10 parts of coix seed, 6 parts of tangerine peel, 6 parts of curcuma, 8 parts of millettia reticulata, 2 parts of coptis root, 10 parts of talc, 10 parts of dandelion, and 6 parts of licorice.

[0035] Example 9 In Example 9 of the present invention, a decoction-free Chinese medicine granule for treating oral lichen planus is provided, and the decoction-free Chinese medicine granule comprises the following weights of single Chinese medicine formula granules: 10g of patchouli, 8g of white peony root, 10g of white peony root, 10g of coix seed, 6g of tangerine peel, 6g of curcuma, 8g of millettia reticulata, 2g of coptis root, 10g of talc, 10g of dandelion, and 6g of licorice.

[0036] Example 10 In embodiment 10 of the present invention, a decoction-free Chinese medicine granule for treating oral lichen planus is provided, and the decoction-free Chinese medicine granule comprises the following weights of single Chinese medicine formula granules: 10g of patchouli, 8g of white peony root, 8g of coix seed, 6g of tangerine peel, 10g of curcuma, 8g of millettia reticulata, 2g of coptis root, 8g of talc, 12g of dandelion, and 6g of licorice.

[0037] Embodiment 11 In Example 11 of the present invention, a decoction-free Chinese medicine granule for treating oral lichen planus is provided, and the decoction-free Chinese medicine granule comprises the following weights of single Chinese medicine formula granules: 10g of patchouli, 6g of white peony root, 10g of white peony root, 10g of coix seed, 6g of tangerine peel, 10g of curcuma, 6g of Millettia reticulata, 2g of coptis root, 7g of talc, 12g of dandelion, and 6g of licorice.

[0038] Example 12 In Example 12 of the present invention, a Chinese medicine decoction-free granule for treating oral lichen planus is provided, and the Chinese medicine decoction-free granule comprises the following weights of single Chinese medicine formula granules: 10g of patchouli, 6g of white peony root, 10g of white peony root, 8g of coix seed, 10g of tangerine peel, 10g of curcuma, 10g of Millettia reticulata, 2g of coptis root, 7g of talc, 10g of dandelion, and 6g of licorice.

[0039] Embodiment 13 In Example 13 of the present invention, a decoction-free Chinese medicine granule for treating oral lichen planus is provided, and the decoction-free Chinese medicine granule comprises the following weights of single Chinese medicine formula granules: 10g of patchouli, 8g of white peony root, 6g of white peony root, 8g of coix seed, 6g of tangerine peel, 6g of curcuma, 8g of millettia reticulata, 5g of coptis root, 8g of talc, 12g of dandelion, and 6g of licorice.

[0040] Embodiment 14 In Example 14 of the present invention, a decoction-free Chinese medicine granule for treating oral lichen planus is provided, and the decoction-free Chinese medicine granule comprises the following weights of single Chinese medicine formula granules: 10g of patchouli, 8g of white peony root, 6g of white peony root, 10g of coix seed, 6g of tangerine peel, 6g of curcuma, 8g of millettia reticulata, 2g of coptis root, 8g of talc, 12g of dandelion, and 6g of licorice.

[0041] Embodiment 15 In Example 15 of the present invention, a decoction-free Chinese medicine granule for treating oral lichen planus is provided, and the decoction-free Chinese medicine granule comprises the following weights of single Chinese medicine formula granules: 8g of patchouli, 8g of white peony root, 8g of white peony root, 10g of coix seed, 6g of tangerine peel, 8g of curcuma, 8g of millettia reticulata, 2g of coptis root, 8g of talc, 12g of dandelion, and 6g of licorice.

[0042] Example 16 In Example 16 of the present invention, a decoction-free Chinese medicine granule for treating oral lichen planus is provided, and the decoction-free Chinese medicine granule comprises the following weights of single Chinese medicine formula granules: 10g of patchouli, 8g of white peony root, 10g of white peony root, 10g of coix seed, 6g of tangerine peel, 6g of curcuma, 8g of millettia reticulata, 2g of coptis root, 10g of talc, 10g of dandelion, and 6g of licorice.

[0043] In another embodiment of the present invention, there is provided a use of the traditional Chinese medicine composition for treating oral lichen planus according to any one of embodiments 1-8 in the preparation of a medicament for treating oral lichen planus.

[0044] In another embodiment of the present invention, there is provided a use of the decoction-free Chinese medicine granules for treating oral lichen planus according to any one of Examples 9-16 in the preparation of a drug for treating oral lichen planus.

[0045] In the above embodiments of the present invention, the raw materials are all commercially available Chinese medicinal materials, and the single-flavor Chinese medicinal formula granules are all commercially available Chinese medicinal granules.

[0046] The beneficial effects of the decoction-free Chinese medicine granules for treating oral lichen planus provided in the above embodiment will be further illustrated by specific test examples. Meanwhile, for the sake of convenience, the decoction-free Chinese medicine granules for treating oral lichen planus will be referred to as Xiaozhenyin below: The core pathogenesis of oral lichen planus: liver depression, spleen deficiency, and internal victory of dampness.

[0047] TCM diagnostic criteria: The diagnostic criteria for oral lichen planus of liver depression, spleen deficiency and dampness predominance type are based on "Oral Mucosal Pathology" and "TCM Diagnosis" and are developed in combination with clinical experience.

[0048] Symptoms of oral lichen planus: Main symptoms: a1) White keratinized stripes or plaques on the oral mucosa, accompanied by redness or erosion of the surrounding mucosa, accompanied by a burning sensation or pain; a2) A preference for fatty and sweet foods; Secondary symptoms: b1), dry mouth, bitter taste or sticky mouth; b2), irritability or depression; b3), abdominal distension; Tongue and pulse symptoms: red or pale tongue with teeth marks, yellow or white greasy fur, stringy and moist pulse or stringy and thin pulse; Clinical diagnosis: Patients who meet the clinical manifestations of oral lichen planus, have 1 or more main symptoms, 1 or more secondary symptoms, and have consistent tongue and pulse symptoms can be diagnosed.

[0049] Effective cases of Xiaozhenyin in treating oral lichen planus: 1. Patient 1, male, 51 years old, first diagnosed on January 15, 2024.

[0050] Chief complaint: Recurrent pain in the left cheek mucosa for more than 3 years, aggravated for 1 month.

[0051] Current medical history: 3 years ago, the patient often had ulcers in the oral mucosa due to irregular diet and spicy food. The ulcers did not heal for a long time and recurred after recovery. He went to the local hospital for treatment and was treated with oral Western medicine and external medication Xilei San, but the treatment effect was not good. 1 month ago, the patient developed oral mucosal pain after eating spicy food. The symptoms did not improve after oral medication. He came to the hospital for treatment. Symptoms: The patient complained of pain and discomfort in the oral mucosa, accompanied by a burning sensation or pain, dry mouth, bitter mouth, irritability, short and red urine, sticky stools, abdominal distension, red tongue, yellow and greasy tongue coating, and a wiry and slippery pulse.

[0052] Examination: 15*15mm can be seen on the left side of the tongue 2 White keratinized streaks, congestion may be seen in the center of the lesion, the texture is soft and thick, please refer to Figure 1 Image of the patient before treatment.

[0053] Past history: in good health.

[0054] TCM diagnosis: oral erosion, liver depression, spleen deficiency and dampness.

[0055] Western medicine diagnosis: oral lichen planus.

[0056] Treatment method: Soothe the liver and strengthen the spleen, clear away heat and remove dampness.

[0057] The first treatment with Chinese medicine: Xiaozhen Decoction, using the Xiaozhen Decoction as described in Example 9, specifically as follows: Patchouli 10g, Dictamni 8g, White Peony 10g, Coix Seed 10g, Tangerine Peel 6g, Curcuma 6g, Millettia Reticulata 8g, Coptis chinensis 2g, Talcum 10g, Taraxacum 10g, Licorice 6g, 7 doses, taken with water, one dose a day, divided into two doses.

[0058] Follow-up date: January 29, 2024.

[0059] After the first treatment, i.e., two courses of treatment, the patient reported that the pain in the oral mucosa was relieved, with occasional dryness and bitterness in the mouth, yellowish urine, sticky stools, reduced abdominal distension, red tongue, yellow fur, and slippery pulse; Examination: 10*7mm can be seen on the left side of the tongue 2 White keratinized stripes, light texture, please refer to Figure 1 Image of the patient after the first treatment.

[0060] The second treatment with Chinese medicine: Xiaozhen Decoction, using the Xiaozhen Decoction as described in Example 16, specifically as follows: Patchouli 10g, Dictamni 8g, White Peony 10g, Coix Seed 10g, Tangerine Peel 6g, Curcuma 6g, Millettia Reticulata 8g, Coptis chinensis 2g, Talcum 10g, Taraxacum 10g, Licorice 6g, 7 doses, taken with water, one dose a day, divided into two doses.

[0061] After the second treatment, the patient reported no pain in the oral mucosa, occasional dry mouth, no bitter taste, normal urination, sticky stool, good sleep, no abdominal distension, red tongue, yellow tongue coating, and slippery pulse; Examination: 8*6mm can be seen on the left side of the tongue 2 White keratinized stripes, light texture, please refer to Figure 1 Image of the patient after the second treatment.

[0062] 2. Patient 2, female, 47 years old, first visit date: January 15, 2024.

[0063] Chief complaint: Recurrent oral mucosal erosion and pain for more than 2 years, aggravated for 2 weeks.

[0064] Current medical history: The patient developed oral mucosal ulcers without obvious cause 2 years ago. He felt obvious pain when eating spicy and irritating food, and the symptoms recurred. He went to a local clinic for treatment and was given oral treatment with vitamin B and other drugs. The symptoms were slightly relieved. 2 weeks ago, he often stayed up late at work, which aggravated the above symptoms. The symptoms did not improve after taking oral drugs on his own. He came to the clinic for treatment. Symptoms: The patient had pain in the right cheek mucosa, mainly with a burning sensation, grid-like white stripes on the oral mucosa, slight congestion of the mucosa at the lesion site accompanied by dry mouth and bitter taste, irritability, general heaviness, short and red urine, sticky stools, poor sleep, red tongue, yellow and greasy tongue coating, tooth marks on the edge of the tongue, and a slippery and rapid pulse.

[0065] Examination: Congestion of the cheek mucosa can be seen on the right side, 25*10mm 2 White keratinized stripes, light texture, please refer to Figure 2 Image of the patient before treatment.

[0066] Menstrual history: menarche at the age of 14, early menstruation, history of dysmenorrhea, small blood clots, dark red color, normal amount.

[0067] Past history: in good health.

[0068] TCM diagnosis: oral erosion, liver depression, spleen deficiency and dampness.

[0069] Western medicine diagnosis: oral lichen planus.

[0070] Treatment method: Soothe the liver and strengthen the spleen, clear away heat and remove dampness.

[0071] The first treatment with Chinese medicine: Xiaozhen Decoction, using the Xiaozhen Decoction as described in Example 10, specifically as follows: Patchouli 10g, Dictamni 8g, White Peony 8g, Coix Seed 8g, Tangerine Peel 6g, Curcuma 10g, Millettia 8g, Coptis 2g, Talcum 8g, Taraxacum 12g, Licorice 6g, 7 doses, taken with water, one dose a day, divided into two doses.

[0072] Follow-up date: January 22, 2024.

[0073] After the first treatment, the patient reported that the pain in the right cheek mucosa was relieved, and he occasionally had dry mouth and bitter taste in the mouth, which was more obvious in the morning, normal bowel movements, poor sleep, red tongue, yellow tongue coating, and slippery pulse; Examination: Congestion of the right cheek mucosa was observed, with a 15*12mm 2 White keratinized stripes, light texture, please refer to Figure 2 Image of the patient after the first treatment.

[0074] The second treatment with Chinese medicine: Xiaozhen Decoction, using the Xiaozhen Decoction as described in Example 9, specifically as follows: Patchouli 10g, Dictamni 8g, White Peony 10g, Coix Seed 10g, Tangerine Peel 6g, Curcuma 6g, Millettia Spatholobi 8g, Coptis chinensis 2g, Talcum 10g, Taraxacum 10g, Licorice 6g, 7 doses, taken with water, one dose a day, divided into two doses.

[0075] After the second treatment, the patient reported no obvious pain in the right cheek mucosa, no local numbness, normal bowel movements, less sleep than before, red tongue, yellow fur, and soft pulse; Examination: Congestion of the right cheek mucosa was observed, with a size of 8*4 mm. 2 White keratinized stripes, light texture, please refer to Figure 2 Image of the patient after the second treatment.

[0076] 3. Patient 3, female, 52 years old, first diagnosed on May 13, 2024.

[0077] Chief complaint: bilateral cheek mucosal pain for more than half a year.

[0078] Current medical history: The patient developed cheek mucosal pain without obvious cause half a year ago, especially when eating. The symptoms would be relieved after eating, but the symptoms often recurred during this period. Recently, the above symptoms reappeared due to staying up late frequently. The symptoms did not improve after oral medication. Now in order to seek further treatment, he came to the hospital for treatment. Current symptoms: The patient complained of pain and discomfort in the oral mucosa, obvious pain when eating spicy and irritating food, fatigue, accompanied by dry mouth and bitter taste, yellow urine, sticky stool, poor appetite, poor sleep quality, pale tongue, white and greasy tongue coating, tooth marks on the edge of the tongue, and stringy and moist pulse.

[0079] Examination: A 10*12mm thick lump can be seen on the right cheek near the lower 6 teeth 2White keratinized streaks, light texture, local mucosal redness and swelling, please refer to Figure 3 Image of the patient before treatment.

[0080] Menstrual history: Menarche at age 14, regular menstruation, dark red color, normal flow.

[0081] Past history: in good health.

[0082] TCM diagnosis: oral erosion, liver depression, spleen deficiency and dampness.

[0083] Western medicine diagnosis: oral lichen planus.

[0084] Treatment method: Soothe the liver and strengthen the spleen, clear away heat and remove dampness.

[0085] The first treatment with Chinese medicine: Xiaozhen Decoction, using the Xiaozhen Decoction as described in Example 11, specifically as follows: Patchouli 10g, Dictamni 6g, White Peony 10g, Coix Seed 10g, Tangerine Peel 6g, Curcuma 10g, Millettia 6g, Coptis chinensis 2g, Talcum 7g, Taraxacum 12g, Licorice 6g, 7 doses, taken with water, one dose a day, divided into two doses.

[0086] Follow-up date: May 20, 2024.

[0087] After the first treatment, the patient reported that the pain in the right oral mucosa was relieved, there was no local numbness, fatigue, pale tongue, greasy white fur, teeth marks on the tongue edge, and stringy pulse; Examination: A 6*8mm diameter can be seen on the right cheek near the lower 6 teeth 2 White keratinized stripes, light texture, please refer to Figure 3 Image of the patient after the first treatment.

[0088] The second treatment with Chinese medicine: Xiaozhen Decoction, using the Xiaozhen Decoction as described in Example 12, specifically as follows: Patchouli 10g, Dictamni 6g, White Peony 10g, Coix Seed 8g, Tangerine Peel 10g, Curcuma 10g, Millettia 10g, Coptis chinensis 2g, Talcum 7g, Taraxacum 10g, Licorice 6g, 7 doses, taken with water, one dose a day, taken in two doses.

[0089] After the second treatment, the patient reported no pain in the right oral mucosa, no other discomfort, pale tongue, greasy white fur, tooth marks on the tongue edge, and soft pulse; Examination: 4*5mm can be seen on the right cheek 2 White stripes, light texture, please refer to Figure 3 Image of the patient after the second treatment.

[0090] 4. Patient 4, female, 31 years old, first visit date: April 22, 2024.

[0091] Chief complaint: Pain in the left cheek mucosa for more than 3 months.

[0092] Current medical history: The patient often stayed up late and had irregular work and rest schedules 3 months ago, and had pain in the left cheek mucosa, with a diameter of 5*10mm. 2 The ulcer surface of the patient complained of pain and discomfort in the left cheek mucosa, with obvious tingling, obvious pain when eating spicy and irritating food, accompanied by numbness and discomfort, red tongue, yellow and greasy tongue coating, tooth marks on the edge of the tongue, and rapid and stringy pulse.

[0093] Examination: 20*15mm can be seen on the left cheek 2 White keratinized streaks, medium texture, scattered distribution, redness and swelling of the affected mucosa, please refer to Figure 4 Image of the patient before treatment.

[0094] Menstrual history: Menarche at age 14, regular menstruation, dark red color, normal flow.

[0095] Past history: in good health.

[0096] TCM diagnosis: oral erosion, liver depression, spleen deficiency and dampness.

[0097] Western medicine diagnosis: oral lichen planus.

[0098] Treatment method: Soothe the liver and strengthen the spleen, clear away heat and remove dampness.

[0099] The first treatment with Chinese medicine: Xiaozhen Decoction, using the Xiaozhen Decoction as described in Example 13, specifically as follows: Patchouli 10g, Dictamni 8g, White Peony 6g, Coix Seed 8g, Tangerine Peel 6g, Curcuma 6g, Millettia Reticulata 8g, Coptis chinensis 5g, Talcum 8g, Taraxacum 12g, Licorice 6g, 7 doses, taken with water, one dose a day, divided into two doses.

[0100] Follow-up date: April 29, 2024.

[0101] After the first treatment, the patient reported that the tightness of the left cheek mucosa was relieved, the tingling sensation was relieved during the day, and the symptoms were more obvious at night. He felt pain when eating spicy and irritating foods, and felt local numbness and discomfort. His tongue was red, with yellow fur, teeth marks on the sides of the tongue, and his pulse was stringy and slippery. Examination: 20*13mm can be seen on the left cheek 2 White keratinized streaks, lighter in color, medium in texture, scattered, see Figure 4 Image of the patient after the first treatment.

[0102] The second treatment with Chinese medicine: Xiaozhen Decoction, using the Xiaozhen Decoction as described in Example 14, specifically as follows: Patchouli 10g, Dictamni 8g, White Peony 6g, Coix Seed 10g, Tangerine Peel 6g, Curcuma 6g, Millettia Reticulata 8g, Coptis chinensis 2g, Talcum 8g, Taraxacum 12g, Licorice 5g, 7 doses, taken with water, one dose per day, divided into two doses.

[0103] After the second treatment, the patient reported that the tingling sensation in the left cheek mucosa was significantly relieved, the numbness and tightness were reduced, the tongue was dark red, the tongue coating was thin and yellow, and the pulse was stringy and thin; Examination: 16*10mm is visible on the left cheek 2 White keratinized streaks, lighter in color, medium in texture, scattered, see Figure 4 Image of the patient after the second treatment.

[0104] After the second treatment, a third treatment was conducted, using the same prescription as the second treatment; After the third treatment, the patient reported that the tingling sensation in the left cheek mucosa was significantly relieved, with no numbness or tightness, and the tongue was pale red with a thin coating and a fine pulse; Examination: 5*5mm is visible on the left cheek 2 White keratinized stripes, lighter color, lighter texture, please refer to Figure 4 Image of the patient after the third treatment.

[0105] 5. Patient 5, 29 years old, first diagnosis date: July 8, 2024.

[0106] Chief complaint: Bilateral buccal mucosal erosions for 3 years, aggravated for 1 month.

[0107] Current medical history: 3 years ago, the patient developed a white keratinized stripe on the left side of the tongue, the size of which was 5*8mm, due to frequent smoking and drinking, plus staying up late. 2 , the symptoms were relieved after self-medication, but they were aggravated every time he ate spicy food, and the symptoms were repeated. One month ago, he had pain and discomfort in the cheek mucosa again after eating spicy food, mainly tingling. The symptoms did not improve after oral medication. Now he came to see a doctor for further treatment. Symptoms: The patient complained of pain and discomfort in the cheek mucosa on both sides, obvious pain when eating, numbness at the tip of the tongue, bitter taste in the mouth in the morning, frequent chest tightness, fear of heat, easy sweating, yellow urine, sticky stool, normal diet, good sleep, red tongue, yellow and greasy tongue coating, tooth marks on the edge of the tongue, and weak and rapid pulse.

[0108] Examination: 15*10mm can be seen on the left cheek mucosa 2 White keratotic streaks, soft and thick, visible on the right cheek 8*10mm 2 White keratinized stripes, soft and thick texture, please refer to Figure 5 Image of the patient before treatment.

[0109] Past history: in good health.

[0110] TCM diagnosis: oral erosion, liver depression, spleen deficiency and dampness.

[0111] Western medicine diagnosis: oral lichen planus.

[0112] Treatment method: Soothe the liver and strengthen the spleen, clear away heat and remove dampness.

[0113] The first treatment with Chinese medicine: Xiaozhen Decoction, using the Xiaozhen Decoction as described in Example 14, specifically as follows: Patchouli 10g, Dictamni 8g, White Peony 6g, Coix Seed 10g, Tangerine Peel 6g, Curcuma 6g, Millettia Reticulata 8g, Coptis chinensis 2g, Talcum 8g, Taraxacum 12g, Licorice 5g, 7 doses, taken with water, one dose per day, divided into two doses.

[0114] Follow-up date: July 15, 2024.

[0115] After the first treatment, the patient reported that the pain in the buccal mucosa on both sides was relieved, the numbness at the tip of the tongue was relieved, bowel movements were normal, the tongue was light red, the tongue coating was white and greasy, and the pulse was soft; Examination: 10*6mm can be seen on the left cheek mucosa 2 White keratotic streaks, light in texture, 8*10mm visible on the right cheek 2 White keratinized stripes, light texture, please refer to Figure 5 Image of the patient after the first treatment.

[0116] The second treatment with Chinese medicine: Xiaozhen Decoction, using the Xiaozhen Decoction as described in Example 15, specifically as follows: Patchouli 8g, Dictamni 8g, White Peony 8g, Coix Seed 10g, Tangerine Peel 6g, Curcuma 8g, Millettia Spatholobi 8g, Coptis chinensis 2g, Talcum 8g, Taraxacum 12g, Licorice 8g, 7 doses, taken with water, one dose a day, divided into two doses.

[0117] After the second treatment, the patient reported no pain in the cheek mucosa on both sides, good sleep, normal bowel movements, pale red tongue, white fur, and a soft pulse. Examination: 4*4mm can be seen on the left cheek mucosa 2 White keratotic streaks, light texture, light texture, please refer to Figure 5 Image of the patient after the second treatment.

[0118] It should be noted that the above-mentioned moss-eliminating drink can also correspond to the Chinese medicine composition described in Examples 1-9.

[0119] In summary, the present invention focuses on soothing the liver, invigorating the spleen and eliminating dampness, supplemented by regulating qi and activating blood circulation, so that liver depression can be relieved, qi can be regulated and blood vessels can be unblocked, spleen function can be strengthened, and water and dampness can be normally transported and distributed, thereby achieving the purpose of treating oral lichen planus of liver depression, spleen deficiency and dampness predominance type. The whole prescription has rigorous compatibility, and the monarch, minister, assistant and envoy perform their respective functions. The effects of soothing the liver, invigorating the spleen, eliminating dampness, activating blood circulation and clearing away heat complement each other. It not only targets the main pathogenesis of soothing the liver, invigorating the spleen and eliminating dampness, but also takes into account the pathological changes of blood stasis and stagnation of heat, reflecting the holistic concept and principle of syndrome differentiation and treatment in the treatment of oral lichen planus in traditional Chinese medicine.

[0120] The above-mentioned embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the patent of the present invention. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A Chinese medicine composition for treating oral lichen planus, characterized in that: The Chinese medicine composition comprises the following raw materials in parts by weight: 8-10 parts of patchouli, 6-8 parts of dittany, 6-10 parts of white peony root, 8-10 parts of coix seed, 6-10 parts of tangerine peel, 6-10 parts of turmeric, 6-10 parts of millettia reticulata, 2-5 parts of coptis root, 7-10 parts of talc, 10-12 parts of dandelion, and 5-8 parts of liquorice.

2. The Chinese medicine composition for treating oral lichen planus according to claim 1, characterized in that: The Chinese medicine composition comprises the following raw materials in parts by weight: 10 parts of patchouli, 8 parts of dittany, 10 parts of white peony root, 10 parts of coix seed, 6 parts of dried orange peel, 6 parts of curcuma, 8 parts of millettia, 2 parts of coptis, 10 parts of talc, 10 parts of dandelion, and 6 parts of liquorice.

3. Use of the traditional Chinese medicine composition for treating oral lichen planus according to claim 1 or 2 in the preparation of a medicament for treating oral lichen planus.

4. A decoction-free Chinese medicine granule for treating oral lichen planus, characterized in that: The Chinese medicine decoction-free granules include the following single-ingredient Chinese medicine formula granules in parts by weight: 8-10 parts of patchouli, 6-8 parts of dittany, 6-10 parts of white peony root, 8-10 parts of coix seed, 6-10 parts of tangerine peel, 6-10 parts of turmeric, 6-10 parts of millettia reticulata, 2-5 parts of coptis root, 7-10 parts of talc, 10-12 parts of dandelion, and 5-8 parts of liquorice.

5. The Chinese medicine decoction-free granules for treating oral lichen planus according to claim 4, characterized in that: The Chinese medicine decoction-free granules include the following single-ingredient Chinese medicine formula granules in parts by weight: 10 parts of patchouli, 8 parts of dittany, 10 parts of white peony root, 10 parts of coix seed, 6 parts of dried orange peel, 6 parts of curcuma, 8 parts of millettia, 2 parts of coptis, 10 parts of talc, 10 parts of dandelion, and 6 parts of liquorice.

6. Use of the decoction-free Chinese medicinal granules for treating oral lichen planus according to claim 4 or 5 in preparing a drug for treating oral lichen planus.

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