Natural raw material synergistic health-care tea drink capable of reducing blood pressure and preparation method of health-care tea drink

Abstract

The present invention discloses a natural raw material synergistic blood pressure lowering health-care tea drink and a preparation method thereof, and relates to the technical field of health-care tea drinks, the raw materials comprise, by weight, 50 parts of radix glehniae, 20 parts of radix angelicae and 20 parts of fructus psoraleae, and the auxiliary materials comprise, by weight, 3 parts of sodium benzoate, 3 parts of sodium cyclamate, 2 parts of chitosan, 2 parts of xanthan gum, 0.1 part of lemon yellow and 0.1 part of carmine. According to the blood pressure-reducing health-care tea drink with natural raw materials synergistic interaction, the synergistic interaction among the raw materials is realized through the matching effect among the radix glehniae, the fructus psoraleae and the radix angelicae, the radix glehniae has the effects of reducing blood pressure and blood fat, improving digestion, improving sleep and the like, and the radix angelicae has the effects of reducing blood pressure, relieving exterior syndrome, dispelling wind, relieving pain, eliminating dampness, arresting leucorrhea, diminishing swelling, expelling pus and the like; the psoralen has pharmacological effects of strengthening heart, resisting osteoporosis, resisting tumors, resisting oxidation, protecting nerves and the like, and the active component methoxysarin is extracted and added into the tea drink, so that the tea drink can efficiently reduce blood pressure and improve blood circulation.

Description

Technical Field

[0001] The invention relates to the technical field of health tea drinks, and in particular to a blood pressure lowering health tea drink with synergistic effects of natural raw materials and a preparation method thereof. Background Art

[0002] With the acceleration of modern life and changes in eating habits, chronic diseases such as hypertension are becoming more common worldwide. Long-term hypertension can easily lead to serious complications such as heart disease and stroke, posing a threat to people's health. Natural Chinese herbal medicines often contain methoxsalen, which is a natural product of furanocoumarins extracted from natural plants. It is also known as prickly ash toxin, methoxypsoralen, and 8-methoxypsoralen. It is an odorless, white to cream-colored crystalline solid with multi-target antihypertensive effects, low toxicity, and low resistance to drug resistance. It can effectively lower blood pressure and improve blood circulation.

[0003] Health tea is a healthy drink that is both a medicine and food and is developed based on the scientific theory and practice of traditional Chinese medicine. For patients with hypertension, although traditional blood pressure lowering methods are effective, they may bring certain side effects, leading to electrolyte disorders in the human body, and long-term medication is prone to drug resistance. In addition, there are people whose blood pressure is high but who do not need medication yet. Existing health drinks containing ingredients such as hawthorn and dendrobium cannot extract the effective ingredients in the raw materials and achieve the synergistic effect between the raw materials. Therefore, the blood pressure lowering and health care effect is poor, and it is not suitable for people with high blood pressure but do not need medication yet. Therefore, it is necessary to provide a health tea that can prevent and control high blood pressure. Summary of the invention

[0004] The purpose of the present invention is to provide a blood pressure lowering health tea with synergistic natural raw materials and a preparation method thereof, so as to solve the shortcomings of the health drinks in the prior art that the effective ingredients in the raw materials cannot be extracted to achieve the synergistic effect between the raw materials, the blood pressure lowering health care effect is poor, and it is not suitable for people with high blood pressure but do not need medication yet.

[0005] In order to achieve the above-mentioned purpose, the present invention provides the following technical scheme: a blood pressure lowering health tea with synergistic natural raw materials, wherein the raw materials include, by weight: 20-50 parts of Northern Adenophora, 10-30 parts of Angelica dahurica, 10-30 parts of Psoralea corylifolia, 1-5 parts of preservatives, 1-5 parts of sweeteners, 1-3 parts of clarifiers, 1-3 parts of stabilizers, 0.05-0.1 parts of pigment one, 0.05-0.1 parts of pigment two, 80-100 parts of flavoring agent one, and 80-100 parts of flavoring agent two.

[0006] Furthermore, the preservative is sodium benzoate, the sweetener is cyclamate, the clarifier is chitosan, the stabilizer is xanthan gum, the first pigment is tartrate, the second pigment is carmine, the first flavoring agent is mixed fruit syrup, and the second flavoring agent is oolong tea syrup.

[0007] The present invention also discloses a method for preparing a blood pressure lowering health tea drink with synergistic effects of natural raw materials, and the preparation method specifically comprises the following steps:

[0008] S1, raw material pretreatment: select Adenophora radix, Angelica dahurica, and Psoralea corylifolia according to the selected weight, mix them, then wash and remove impurities, and then grind and sieve them by a grinder, and dry them by spray drying to obtain plant raw material powder, which is reserved for later use;

[0009] S2, extraction of active ingredients: soaking the plant raw material powder obtained in S1 in an organic solvent by solvent extraction, then shaking and filtering solid impurities to obtain an extract, then distilling the extract to remove the solvent, and finally separating and purifying to obtain a concentrated methoxsalen-containing extract;

[0010] S3, seasoning and mixing: sodium benzoate, sodium cyclamate, chitosan, xanthan gum, tartrazine and carmine are selected according to their weight and added in sequence to the concentrated methoxsalen-containing extract obtained in S2, seasoned to obtain a mixed solution, and then fully stirred the mixed solution with a stirring device, and then concentrated to obtain a tea base solution;

[0011] S4, granulation and drying: granulating the tea base liquid obtained in S3, and then performing low-temperature drying after granulation to obtain a solid powdered tea granule;

[0012] S5. Packaging and storage: The solid powdered tea beverage obtained in S4 is sealed and packaged into strip-shaped aluminum foil bags or small packaging bags, and then equal amounts of mixed fruit syrup and oolong tea syrup are separately sealed and packaged, and finally stored in a warehouse.

[0013] Furthermore, the mass ratio of Adenophora adenophora, Angelica dahurica and Psoralea corylifolia in S1 is 2-5:1-3:1-3.

[0014] Furthermore, the crushing particle size of the pulverizer in S1 is 50-60 mesh, and the drying temperature of the spray drying method is set to 20-40°C.

[0015] Furthermore, the organic solvent in S2 is any one of methanol, ethanol or acetone; and the mass ratio of the plant raw material powder to the organic solvent in S2 is 1:5-10.

[0016] Furthermore, the soaking time in S2 is 6 to 12 hours; the distillation method in S2 is rotary evaporation or reduced pressure distillation.

[0017] Furthermore, the stirring time of the stirring device in S3 is set to 10 to 30 minutes, and the rotation speed is set to 80 to 100 r / min; after the mixed liquid is fully stirred by the stirring device in S3, it is concentrated. At this time, the concentration pressure is set to 20 to 60 mmHg, and the temperature is set to 30 to 50°C.

[0018] Furthermore, the low-temperature drying temperature in S4 is set to 20-40°C.

[0019] Compared with the prior art, the blood pressure lowering health tea drink with synergistic effects of natural raw materials provided by the present invention has the following advantages:

[0020] 1. The health tea of ​​the present invention can achieve synergistic effects among the raw materials through the cooperation between Glehnia littoralis, Psoralea corylifolia and Angelica dahurica. Glehnia littoralis has the effects of lowering blood pressure and blood lipids, improving digestion, promoting metabolism, improving sleep and the like; Angelica dahurica has the effects and functions of lowering blood pressure, relieving exterior symptoms and dispersing wind, relieving pain, drying dampness and stopping leukorrhea, reducing swelling and discharging pus and the like; Psoralea corylifolia has the pharmacological effects of strengthening the heart, resisting osteoporosis, resisting tumor, resisting oxidation and protecting nerves and the like; Glehnia littoralis can play a harmonizing role, Angelica dahurica provides aroma and spiciness, and Psoralea corylifolia can provide a certain drug effect strength. The raw materials used are widely available and cost-effective. While having a good blood pressure-lowering effect, it can ensure food safety and help maintain the overall health of the body.

[0021] 2. The antihypertensive active ingredient methoxsalen in the health tea of ​​the present invention is extracted from natural medicinal materials such as Angelica dahurica, Psoralea corylifolia and Adenophora paniculata, which are both medicinal and edible. Its mechanism of action is multi-target, which can effectively lower blood pressure and improve blood circulation, and is not easy to produce drug resistance.

[0022] 3. The health tea of ​​the present invention combines the Chinese herbal medicine theory in traditional medicine with modern scientific and technological means, and provides a health tea that can prevent and control high blood pressure. It extracts methoxsalen, an effective ingredient of natural Chinese herbal medicine, and uses modern food processing technology to prepare it. The taste is balanced by adjusting the proportion of raw materials, and auxiliary materials such as syrup and sweetener are used to reduce the bitterness of the medicinal materials, and ensure that the final taste is suitable, so that the blood pressure-lowering health tea has the conditioning effect of traditional medicine and meets the taste requirements of modern people. Long-term use can not only effectively prevent high blood pressure, but also effectively improve the phenomenon of high blood pressure in people who do not need medication yet. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in the present invention. For ordinary technicians in this field, other drawings can also be obtained based on these drawings.

[0024] Figure 1 It is a flow chart of the preparation process of the present invention. DETAILED DESCRIPTION

[0025] In order to enable those skilled in the art to better understand the technical solution of the present invention, the present invention will be further described in detail below with reference to the accompanying drawings.

[0026] Embodiment 1:

[0027] See also Figure 1 , a health tea for lowering blood pressure with synergistic effects of natural raw materials. The raw materials include, by weight: 50 parts of Northern Adenophora, 20 parts of Angelica dahurica, 20 parts of Psoralea corylifolia, 3 parts of sodium benzoate, 3 parts of cyclamate, 2 parts of chitosan, 2 parts of xanthan gum, 0.1 parts of tartrazine, 0.1 parts of carmine, 80 parts of mixed fruit syrup, and 80 parts of oolong tea syrup.

[0028] The present invention also discloses a method for preparing a blood pressure lowering health tea drink with synergistic effects of natural raw materials, and the preparation method specifically comprises the following steps:

[0029] S1, raw material pretreatment: according to the selected weight points, the dried rhizome parts of Adenophora scabra, Angelica dahurica and Psoralea corylifolia are mixed, then washed and impurities are removed, and then crushed and sieved by a pulverizer, and finally dried by spray drying to obtain plant raw material powder, which is reserved for later use;

[0030] S2, extraction of active ingredients: soaking the plant raw material powder obtained in S1 in ethanol by solvent extraction, then shaking and filtering solid impurities to obtain an extract, then distilling the extract to remove ethanol, and finally separating and purifying to obtain a concentrated methoxsalen-containing extract;

[0031] S3, seasoning and mixing: sodium benzoate, sodium cyclamate, chitosan, xanthan gum, tartrazine and carmine are selected according to their weight and added in sequence to the concentrated methoxsalen-containing extract obtained in S2, and a mixed solution is obtained after seasoning to improve the stability of the product and the taste when drinking, and then the mixed solution is fully stirred by a stirring device to ensure that the components are evenly distributed, and then concentrated to obtain a tea base liquid;

[0032] S4, granulation and drying: granulating the tea base liquid obtained in S3 to improve the solubility and taste during brewing, and then performing low-temperature drying after granulation to obtain a solid powdered tea granule;

[0033] S5. Packaging and storage: The solid powdered tea powder obtained in S4 is sealed and packaged into strip-shaped aluminum foil bags or small packaging bags. At this point, the tea powder has the ability to be preserved for a long time. Then, equal amounts of mixed fruit syrup and oolong tea syrup are separately sealed and packaged for consumers to season themselves, and finally stored in warehouses.

[0034] The mass ratio of Adenophora radix, Angelica dahurica and Psoralea corylifolia in S1 is 5:2:2; the pulverizing particle size of the pulverizer is 50 mesh, and the spray drying temperature is set to 40°C.

[0035] The organic solvent in S2 is ethanol; the mass ratio of the plant raw material powder to the organic solvent in S2 is 1:5; the soaking time in S2 is 8 hours; and the distillation method in S2 is rotary evaporation.

[0036] The stirring time of the stirring device in S3 is set to 30 minutes, and the rotation speed is set to 80 r / min. After the mixed liquid is fully stirred by the stirring device in S3, it is concentrated. At this time, the concentration pressure is set to 60 mmHg and the temperature is set to 30°C.

[0037] The low temperature drying temperature in S4 was set to 40°C.

[0038] The specific implementation method is that the mass ratio of Adenophora acuminata, Angelica dahurica and Psoralea corylifolia in the raw materials is 5:2:2, among which Adenophora acuminata has the highest proportion. Adenophora acuminata has the effect of nourishing yin and replenishing deficiency, can enhance specific immunity and nonspecific immunity, has multiple pharmacological effects such as antitussive and expectorant, antipyretic and analgesic, antioxidant, anti-tumor, anti-mutation, and also has the effects of lowering blood pressure and blood lipids, improving digestion, promoting metabolism, improving sleep, etc. In addition to ensuring its antihypertensive effect, improving the use of Adenophora acuminata can also ensure that the taste of tea is relatively soft, which is suitable for people who are trying this kind of product for the first time, are more sensitive to the content of ingredients, and have a light taste. In addition, users can add mixed fruit syrup and oolong tea syrup according to their own preferences to adjust the taste and increase the palatability of the product.

[0039] Embodiment 2:

[0040] See also Figure 1 This embodiment provides a technical solution based on the first embodiment: a health tea drink for lowering blood pressure with synergistic effects of natural raw materials, wherein the raw materials include by weight: 50 parts of Adenophora adenophora, 20 parts of Angelica dahurica, 30 parts of Psoralea corylifolia, 1 part of sodium benzoate, 3 parts of cyclamate, 1 part of chitosan, 1 part of xanthan gum, 0.1 part of tartrazine, 0.1 part of carmine, 80 parts of mixed fruit syrup, and 80 parts of oolong tea syrup.

[0041] The present invention also discloses a method for preparing a blood pressure lowering health tea drink with synergistic effects of natural raw materials, and the preparation method specifically comprises the following steps:

[0042] S1, raw material pretreatment: according to the selected weight points, the dried rhizome parts of Adenophora scabra, Angelica dahurica and Psoralea corylifolia are mixed, then washed and impurities are removed, and then crushed and sieved by a pulverizer, and finally dried by spray drying to obtain plant raw material powder, which is reserved for later use;

[0043] S2, extraction of active ingredients: soaking the plant raw material powder obtained in S1 in ethanol by solvent extraction, then shaking and filtering solid impurities to obtain an extract, then distilling the extract to remove ethanol, and finally separating and purifying to obtain a concentrated methoxsalen-containing extract;

[0044] S3, seasoning and mixing: sodium benzoate, sodium cyclamate, chitosan, xanthan gum, tartrazine and carmine are selected according to their weight and added in sequence to the concentrated methoxsalen-containing extract obtained in S2, and a mixed solution is obtained after seasoning to improve the stability of the product and the taste when drinking, and then the mixed solution is fully stirred by a stirring device to ensure that the components are evenly distributed, and then concentrated to obtain a tea base liquid;

[0045] S4, granulation and drying: granulating the tea base liquid obtained in S3 to improve the solubility and taste during brewing, and then performing low-temperature drying after granulation to obtain a solid powdered tea granule;

[0046] S5. Packaging and storage: The solid powdered tea powder obtained in S4 is sealed and packaged into strip-shaped aluminum foil bags or small packaging bags. At this point, the tea powder has the ability to be preserved for a long time. Then, equal amounts of mixed fruit syrup and oolong tea syrup are separately sealed and packaged for consumers to season themselves, and finally stored in warehouses.

[0047] The mass ratio of Adenophora radix, Angelica dahurica and Psoralea corylifolia in S1 is 5:2:3; the pulverizing particle size of the pulverizer is 50 mesh, and the spray drying temperature is set to 40°C.

[0048] The organic solvent in S2 is ethanol; the mass ratio of the plant raw material powder to the organic solvent in S2 is 1:5; the soaking time in S2 is 8 hours; and the distillation method in S2 is rotary evaporation.

[0049] The stirring time of the stirring device in S3 is set to 30 minutes, and the rotation speed is set to 80 r / min. After the mixed liquid is fully stirred by the stirring device in S3, it is concentrated. At this time, the concentration pressure is set to 60 mmHg and the temperature is set to 30°C.

[0050] The low temperature drying temperature in S4 was set to 40°C.

[0051] The specific implementation method is that the formula of the highly concentrated functional flavored beverage provided in this embodiment has a mass ratio of Adenophora scabra, Angelica dahurica and Psoralea corylifolia in the raw materials of 5:2:3, which increases the dosage of Psoralea corylifolia. Psoralea corylifolia has pharmacological effects such as strengthening the heart, anti-osteoporosis, anti-tumor, anti-oxidation and neuroprotection. The increase in the dosage of Psoralea corylifolia can make the dosage of the effective ingredient methoxsalen in the raw materials reach a higher level, thereby enhancing the efficacy. It is suitable for people with high blood pressure who have a strong demand for efficacy but do not need medication yet. Users can also adjust the rich taste of the raw medicinal materials by mixing fruit syrup or oolong tea syrup, thereby improving the comprehensive taste and health effects of the beverage.

[0052] Embodiment three:

[0053] See also Figure 1This embodiment provides a technical solution based on the first embodiment: a health tea drink for lowering blood pressure with synergistic effects of natural raw materials, wherein the raw materials include by weight: 40 parts of Adenophora adenophora, 20 parts of Angelica dahurica, 20 parts of Psoralea corylifolia, 1 part of sodium benzoate, 1 part of cyclamate, 3 parts of chitosan, 3 parts of xanthan gum, 0.05 parts of tartrazine, 0.05 parts of carmine, 80 parts of mixed fruit syrup, and 80 parts of oolong tea syrup.

[0054] The present invention also discloses a method for preparing a blood pressure lowering health tea drink with synergistic effects of natural raw materials, and the preparation method specifically comprises the following steps:

[0055] S1, raw material pretreatment: according to the selected weight points, the dried rhizome parts of Adenophora scabra, Angelica dahurica and Psoralea corylifolia are mixed, then washed and impurities are removed, and then crushed and sieved by a pulverizer, and finally dried by spray drying to obtain plant raw material powder, which is reserved for later use;

[0056] S2, extraction of active ingredients: soaking the plant raw material powder obtained in S1 in ethanol by solvent extraction, then shaking and filtering solid impurities to obtain an extract, then distilling the extract to remove ethanol, and finally separating and purifying to obtain a concentrated methoxsalen-containing extract;

[0057] S3, seasoning and mixing: sodium benzoate, sodium cyclamate, chitosan, xanthan gum, tartrazine and carmine are selected according to their weight and added in sequence to the concentrated methoxsalen-containing extract obtained in S2, and a mixed solution is obtained after seasoning to improve the stability of the product and the taste when drinking, and then the mixed solution is fully stirred by a stirring device to ensure that the components are evenly distributed, and then concentrated to obtain a tea base liquid;

[0058] S4, granulation and drying: granulating the tea base liquid obtained in S3 to improve the solubility and taste during brewing, and then performing low-temperature drying after granulation to obtain a solid powdered tea granule;

[0059] S5. Packaging and storage: The solid powdered tea powder obtained in S4 is sealed and packaged into strip-shaped aluminum foil bags or small packaging bags. At this point, the tea powder has the ability to be preserved for a long time. Then, equal amounts of mixed fruit syrup and oolong tea syrup are separately sealed and packaged for consumers to season themselves, and finally stored in warehouses.

[0060] The mass ratio of Adenophora radix, Angelica dahurica and Psoralea corylifolia in S1 is 4:2:2; the pulverizing particle size of the pulverizer is 50 mesh, and the spray drying temperature is set to 40°C.

[0061] The organic solvent in S2 is ethanol; the mass ratio of the plant raw material powder to the organic solvent in S2 is 1:5; the soaking time in S2 is 8 hours; and the distillation method in S2 is rotary evaporation.

[0062] The stirring time of the stirring device in S3 is set to 30 minutes, and the rotation speed is set to 80 r / min. After the mixed liquid is fully stirred by the stirring device in S3, it is concentrated. At this time, the concentration pressure is set to 60 mmHg and the temperature is set to 30°C.

[0063] The low temperature drying temperature in S4 was set to 40°C.

[0064] The specific implementation method is that the low-allergy and light-enjoyment flavored beverage formula provided in this embodiment has a mass ratio of 4:2:2 among the raw materials, namely, Adenophora radix, Angelica dahurica, and Psoralea corylifolia. The dosage of raw medicinal materials is reduced and the ingredients are mild, ensuring that the beverage is more refreshing and suitable for replenishing water. At the same time, the dosage of saccharin is reduced, which is more suitable for people with sensitive constitution or light taste. Users can add mixed fruit syrup or oolong tea syrup according to their preference.

[0065] Embodiment 4:

[0066] See also Figure 1 This embodiment provides a technical solution based on the first embodiment: a health tea drink for lowering blood pressure with synergistic effects of natural raw materials, wherein the raw materials include by weight: 40 parts of Adenophora adenophora, 40 parts of Angelica dahurica, 20 parts of Psoralea corylifolia, 2 parts of sodium benzoate, 4 parts of cyclamate, 2 parts of chitosan, 2 parts of xanthan gum, 0.1 parts of tartrazine, 0.1 parts of carmine, 80 parts of mixed fruit syrup, and 80 parts of oolong tea syrup.

[0067] The present invention also discloses a method for preparing a blood pressure lowering health tea drink with synergistic effects of natural raw materials, and the preparation method specifically comprises the following steps:

[0068] S1, raw material pretreatment: according to the selected weight points, the dried rhizome parts of Adenophora scabra, Angelica dahurica and Psoralea corylifolia are mixed, then washed and impurities are removed, and then crushed and sieved by a pulverizer, and finally dried by spray drying to obtain plant raw material powder, which is reserved for later use;

[0069] S2, extraction of active ingredients: soaking the plant raw material powder obtained in S1 in ethanol by solvent extraction, then shaking and filtering solid impurities to obtain an extract, then distilling the extract to remove ethanol, and finally separating and purifying to obtain a concentrated methoxsalen-containing extract;

[0070] S3, seasoning and mixing: sodium benzoate, sodium cyclamate, chitosan, xanthan gum, tartrazine and carmine are selected according to their weight and added in sequence to the concentrated methoxsalen-containing extract obtained in S2, and a mixed solution is obtained after seasoning to improve the stability of the product and the taste when drinking, and then the mixed solution is fully stirred by a stirring device to ensure that the components are evenly distributed, and then concentrated to obtain a tea base liquid;

[0071] S4, granulation and drying: granulating the tea base liquid obtained in S3 to improve the solubility and taste during brewing, and then performing low-temperature drying after granulation to obtain a solid powdered tea granule;

[0072] S5. Packaging and storage: The solid powdered tea powder obtained in S4 is sealed and packaged into strip-shaped aluminum foil bags or small packaging bags. At this point, the tea powder has the ability to be preserved for a long time. Then, equal amounts of mixed fruit syrup and oolong tea syrup are separately sealed and packaged for consumers to season themselves, and finally stored in warehouses.

[0073] The mass ratio of Adenophora radix, Angelica dahurica and Psoralea corylifolia in S1 is 4:4:2; the particle size of the pulverizer is 50 mesh, and the spray drying temperature is set to 40°C.

[0074] The organic solvent in S2 is ethanol; the mass ratio of the plant raw material powder to the organic solvent in S2 is 1:5; the soaking time in S2 is 8 hours; and the distillation method in S2 is rotary evaporation.

[0075] The stirring time of the stirring device in S3 is set to 30 minutes, and the rotation speed is set to 80 r / min. After the mixed liquid is fully stirred by the stirring device in S3, it is concentrated. At this time, the concentration pressure is set to 60 mmHg and the temperature is set to 30°C.

[0076] The low temperature drying temperature in S4 was set to 40°C.

[0077] The specific implementation method is that the customized formula with fruity aroma preference provided in this embodiment has a mass ratio of Northern Glehnia littoralis, Angelica dahurica, and Psoralea corylifolia in the raw materials of 4:4:2, which increases the dosage of Angelica dahurica. Angelica dahurica has a fragrant aroma, spicy taste, warm nature, and a unique taste with a certain fragrance. The ratio of Angelica dahurica to Northern Glehnia littoralis is equal, which can highlight the aroma of the herbal plants and ensure the rich herbal flavor in the tea. At the same time, the dosage of saccharin is increased, which is suitable for people who prefer fruity aroma and sweet taste.

[0078] Embodiment five:

[0079] See also Figure 1 This embodiment provides a technical solution based on the first embodiment: a health tea drink for lowering blood pressure with synergistic effects of natural raw materials, wherein the raw materials include by weight: 40 parts of Adenophora adenophora, 30 parts of Angelica dahurica, 30 parts of Psoralea corylifolia, 4 parts of sodium benzoate, 2 parts of cyclamate, 2 parts of chitosan, 2 parts of xanthan gum, 0.05 parts of tartrazine, 0.05 parts of carmine, 80 parts of mixed fruit syrup, and 80 parts of oolong tea syrup.

[0080] The present invention also discloses a method for preparing a blood pressure lowering health tea drink with synergistic effects of natural raw materials, and the preparation method specifically comprises the following steps:

[0081] S1, raw material pretreatment: according to the selected weight points, the dried rhizome parts of Adenophora scabra, Angelica dahurica and Psoralea corylifolia are mixed, then washed and impurities are removed, and then crushed and sieved by a pulverizer, and finally dried by spray drying to obtain plant raw material powder, which is reserved for later use;

[0082] S2, extraction of active ingredients: soaking the plant raw material powder obtained in S1 in ethanol by solvent extraction, then shaking and filtering solid impurities to obtain an extract, then distilling the extract to remove ethanol, and finally separating and purifying to obtain a concentrated methoxsalen-containing extract;

[0083] S3, seasoning and mixing: sodium benzoate, sodium cyclamate, chitosan, xanthan gum, tartrazine and carmine are selected according to their weight and added in sequence to the concentrated methoxsalen-containing extract obtained in S2, and a mixed solution is obtained after seasoning to improve the stability of the product and the taste when drinking, and then the mixed solution is fully stirred by a stirring device to ensure that the components are evenly distributed, and then concentrated to obtain a tea base liquid;

[0084] S4, granulation and drying: granulating the tea base liquid obtained in S3 to improve the solubility and taste during brewing, and then performing low-temperature drying after granulation to obtain a solid powdered tea granule;

[0085] S5. Packaging and storage: The solid powdered tea powder obtained in S4 is sealed and packaged into strip-shaped aluminum foil bags or small packaging bags. At this point, the tea powder has the ability to be preserved for a long time. Then, equal amounts of mixed fruit syrup and oolong tea syrup are separately sealed and packaged for consumers to season themselves, and finally stored in warehouses.

[0086] The mass ratio of Adenophora radix, Angelica dahurica and Psoralea corylifolia in S1 is 4:3:3; the pulverizing particle size of the pulverizer is 50 mesh, and the spray drying temperature is set to 40°C.

[0087] The organic solvent in S2 is ethanol; the mass ratio of the plant raw material powder to the organic solvent in S2 is 1:5; the soaking time in S2 is 8 hours; and the distillation method in S2 is rotary evaporation.

[0088] The stirring time of the stirring device in S3 is set to 30 minutes, and the rotation speed is set to 80 r / min. After the mixed liquid is fully stirred by the stirring device in S3, it is concentrated. At this time, the concentration pressure is set to 60 mmHg and the temperature is set to 30°C.

[0089] The low temperature drying temperature in S4 was set to 40°C.

[0090] The specific implementation method is that the tea-flavor-dominated customized formula provided in this embodiment has a mass ratio of Northern Adenophora Root, Angelica Dahurica Root, and Psoralea Corylifolia of 4:3:3 in the raw materials. The raw materials maximize the proportion of Psoralea Corylifolia, increase the proportion of effective ingredients, and highlight the anti-hypertensive effect. It is suitable for users who need a stronger anti-hypertensive effect. The proportion of Northern Adenophora Root in the raw materials is reduced to avoid emphasizing a certain ingredient. At the same time, the amount of saccharin is reduced, which is conducive to highlighting the tea aroma of oolong tea syrup. It is suitable for people who like the aroma of tea and don’t like it to be too sweet.

[0091] Among the above drugs,

[0092] Northern Adenophora: sweet, slightly bitter, and warm in nature; Northern Adenophora has the effects of lowering blood pressure and blood lipids, improving digestion, promoting metabolism, and improving sleep; it also has the effects of nourishing yin and replenishing deficiency, nourishing yin and moistening the lungs, relieving cough and expectorant, relieving fever and pain, antioxidant, anti-tumor, anti-mutation and other pharmacological effects; it can enhance specific and nonspecific immune functions.

[0093] Angelica dahurica: It has a fragrant smell, spicy taste and warm nature. It is rich in chemical components and is used to promote blood circulation, dredge meridians, remove dampness and relieve exterior symptoms. It is often used as one of the compound medicinal materials. It has the effects of lowering blood pressure, relieving exterior symptoms and dispersing wind, relieving pain, drying dampness and stopping leukorrhea, reducing swelling and discharging pus. It also has multiple pharmacological effects such as anti-inflammatory, analgesic, antibacterial, anti-tumor, whitening, vasodilation, and anti-allergic.

[0094] Psoralea corylifolia: It has a fragrant aroma, spicy, slightly bitter taste, and warming effect. Psoralea corylifolia has pharmacological effects such as strengthening the heart, anti-osteoporosis, anti-tumor (can inhibit tumor cells such as breast cancer, prostate cancer, lung cancer, gastric cancer, liver cancer, leukemia, etc. in vitro), anti-oxidation and neuroprotection.

[0095] Embodiment six:

[0096] See also Figure 1 The concentrated methoxsalen extract extracted in any one of Examples 1-5 was applied to a rat test, and the experimental contents were as follows:

[0097] In vitro dilation test of the extract on rat aortic rings:

[0098] Based on the concentrated methoxsalen extract provided in any one of Examples 1 to 5, the methoxsalen powder obtained after drying is tested for its in vitro relaxation effect on rat aorta rings. The test comprises the following steps:

[0099] (1) Preparation before the experiment: Male SD rats, weighing 250-300 g, animal experimental procedures were strictly followed in accordance with the National Institute of Health Guide for the Care and Use of Laboratory Animals (NIH Publication No. 85-23, revised in 1996) and approved by the University Institutional Animal Care and Utilization Committee. Animal housing conditions: two rats per cage, temperature 20-24°C, humidity maintained at 40%-60%, free access to food and water. The standard block feed provided by the Experimental Animal Center of Yanbian University was used for feeding. The experiment began after the animals were kept in the cage for one week. BL-420S Biofunctional Experimental System was purchased from Chengdu Taimeng Technology Co., Ltd.

[0100] (2) Reagents and preparation: Dimethyl sulfoxide (DMSO), phenylephrine (PE), acetylcholine (Ach). Preparation of Kreb's solution: NaCl 118.0 mmol / L, KCl 4.7 mmol / L, CaCl 21.5 mmol / L, MgSO4 1.1 mmol / L, KH2PO4 1.2 mmol / L, NaHCO3 25.0 mmol / L, glucose 10.0 mmol / L (pH = 7.4). Prepare before use, prepare two portions and place them in a refrigerator and a constant temperature water bath respectively.

[0101] (3) Isolation of vascular rings: Male SD rats were killed by cervical dislocation, and their aortas were removed and placed in Kreb's solution. Vascular rings of 3 to 4 mm were prepared.

[0102] (4) Experimental measurement: The separated blood vessels were penetrated through the vascular cavity with two 3.0 cm long thin steel wires, and the two ends were connected to the two perfusion needles in the bath and fixed in the center of the tension transducer water bath. The blood vessel ring was heated and set to 37 degrees Celsius. The blood vessel ring was placed in a Kreb's solution saturated with a mixture of 95% oxygen and 5% carbon dioxide. After zero adjustment, a pretension of 3 mN was given to the blood vessel ring, and the balance was 1.5 to 2.0 hours. During this period, the Kreb's solution was changed every 20 minutes. After the tension of the blood vessel ring was stabilized and balanced, the retained Kreb's solution was removed, and 60 mmol·L-1 K+rich-Kreb's solution was placed in the water bath of the tension transducer to test the contractility of the arterial ring. After the contraction of the blood vessel ring reached a stable platform, the blood vessel ring was rinsed with Kreb's solution three times to restore its tension to the baseline level. The blood vessel ring with a difference of less than 10% in the two contraction amplitudes was used for the experiment. After the vascular contraction stabilized, 5 μL of concentration gradient solutions of the drug to be tested were added in sequence, and the changes in vascular ring tension were recorded to examine the relaxation effects of the target compound on different vascular contractions caused by high potassium solution.

[0103] The in vitro diastolic effects of the extract on rat aortic rings are shown in Table 1

[0104] Table 1 Effects of extracts on in vitro relaxation of rat aortic rings

[0105]

[0106] The results showed that there was a positive correlation between the extract concentration and the vasodilation rate, indicating that methoxsalen, the active ingredient in this natural raw material synergistic blood pressure lowering health tea, can change the vasodilation effect and thus be used to improve blood pressure problems in people who have high blood pressure but do not yet need medication.

[0107] Test on the antihypertensive effect of the extract on essential hypertension:

[0108] Based on the concentrated methoxsalen extract provided in any one of Examples 1 to 5, the methoxsalen powder obtained after drying was tested for its hypotensive effect on rats with essential hypertension. The test comprises the following steps:

[0109] (1) Preparation of experimental materials and instruments: 18 male rats with essential hypertension of 12 weeks old, weighing about 220 g. Methoxsalen extract extracted from a mixture of Adenophora adenophora, Angelica dahurica and Psoralea corylifolia prepared by our laboratory. BP-6 animal non-invasive blood pressure test system (Chengdu TaiP Technology Co., Ltd.).

[0110] (2) Experimental methods: 18 hypertensive rats were randomly divided into 6 groups, 6 rats in each group, namely, a low-dose extract group (1 g / kg), a high-dose extract group (3 g / kg), and a blank control group (equal volume of distilled water was taken in a can). The drug was administered once a day, with a volume of 10 mL / kg each time, for 4 consecutive weeks. The tail artery blood pressure of rats in the awake state was measured every week using the BP-6 non-invasive tail artery blood pressure measurement and analysis system.

[0111] The antihypertensive effect of the extract on essential hypertensive rats is shown in Table 2

[0112] Table 2 Effects of the extract on blood pressure in rats with primary hypertension (mmHg, n=6)

[0113]

[0114] Note: Compared with the blank control group, *P<0.05, **P<0.01

[0115] The results showed that with the increase of extract dosage, the diastolic blood pressure of rats decreased significantly. At the same time, with the increase of administration time, the diastolic blood pressure of rats also decreased significantly. This shows that methoxsalen, the active ingredient in this natural raw material synergistic blood pressure-lowering health tea, can help improve blood pressure problems in people with primary hypertension.

[0116] The above description is only by way of illustration of certain exemplary embodiments of the present invention. It is undoubted that those skilled in the art can modify the described embodiments in various ways without departing from the spirit and scope of the present invention. Therefore, the above drawings and descriptions are illustrative in nature and should not be construed as limiting the scope of protection of the claims of the present invention.

Claims

1. A blood pressure lowering health tea drink with synergistic effects of natural raw materials, characterized in that: The raw materials include, by weight: 20-50 parts of northern adenophora, 10-30 parts of angelica dahurica, 10-30 parts of psoralea corylifolia, 1-5 parts of preservatives, 1-5 parts of sweeteners, 1-3 parts of clarifiers, 1-3 parts of stabilizers, 0.05-0.1 parts of pigment 1, 0.05-0.1 parts of pigment 2, 80-100 parts of flavoring agent 1, and 80-100 parts of flavoring agent 2.

2. The blood pressure lowering health tea drink with synergistic effects of natural raw materials according to claim 1, characterized in that: The preservative is sodium benzoate, the sweetener is cyclamate, the clarifier is chitosan, the stabilizer is xanthan gum, the first pigment is tartrate yellow, the second pigment is carmine, the first flavoring agent is mixed fruit syrup, and the second flavoring agent is oolong tea syrup.

3. The blood pressure lowering health tea drink with synergistic effects of natural raw materials according to any one of claims 1 to 2, characterized in that: The preparation method specifically comprises the following steps: S1, raw material pretreatment: select Adenophora radix, Angelica dahurica, and Psoralea corylifolia according to the selected weight, mix them, then wash and remove impurities, and then grind and sieve them by a grinder, and dry them by spray drying to obtain plant raw material powder, which is reserved for later use; S2, extraction of active ingredients: soaking the plant raw material powder obtained in S1 in an organic solvent by solvent extraction, then shaking and filtering solid impurities to obtain an extract, then distilling the extract to remove the solvent, and finally separating and purifying to obtain a concentrated methoxsalen-containing extract; S3, seasoning and mixing: sodium benzoate, sodium cyclamate, chitosan, xanthan gum, tartrazine and carmine are selected according to their weight and added in sequence to the concentrated methoxsalen-containing extract obtained in S2, seasoned to obtain a mixed solution, and then fully stirred the mixed solution with a stirring device, and then concentrated to obtain a tea base solution; S4, granulation and drying: granulating the tea base liquid obtained in S3, and then performing low-temperature drying after granulation to obtain a solid powdered tea granule; S5. Packaging and storage: The solid powdered tea beverage obtained in S4 is sealed and packaged into strip-shaped aluminum foil bags or small packaging bags, and then equal amounts of mixed fruit syrup and oolong tea syrup are separately sealed and packaged, and finally stored in a warehouse.

4. The method for preparing a blood pressure lowering health tea drink with synergistic effects of natural raw materials according to claim 3, characterized in that: The mass ratio of Adenophora adenophora, Angelica dahurica and Psoralea corylifolia in S1 is 2-5:1-3:1-3.

5. The method for preparing a blood pressure lowering health tea drink with synergistic effects of natural raw materials according to claim 3, characterized in that: The pulverizer in S1 has a pulverizing particle size of 50-60 meshes, and the drying temperature of the spray drying method is set at 20-40°C.

6. The method for preparing a blood pressure lowering health tea drink with synergistic effects of natural raw materials according to claim 3, characterized in that: The organic solvent in S2 is any one of methanol, ethanol or acetone; the mass ratio of the plant raw material powder to the organic solvent in S2 is 1:5-10.

7. The method for preparing a blood pressure lowering health tea drink with synergistic effects of natural raw materials according to claim 3, characterized in that: The soaking time in S2 is 6 to 12 hours; the distillation method in S2 is rotary evaporation or reduced pressure distillation.

8. The method for preparing a blood pressure lowering health tea drink with synergistic effects of natural raw materials according to claim 3, characterized in that: The stirring time of the stirring device in S3 is set to 10-30 min, and the rotation speed is set to 80-100 r / min; after the mixed liquid is fully stirred by the stirring device in S3, it is concentrated. At this time, the concentration pressure is set to 20-60 mmHg and the temperature is set to 30-50°C.

9. The method for preparing a blood pressure lowering health tea drink with synergistic effects of natural raw materials according to claim 3, characterized in that: The low temperature drying temperature in S4 is set to 20-40°C.

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