Ultrasonic thrombolysis treatment device

Abstract

The invention provides an ultrasonic thrombolysis treatment device. The ultrasonic thrombolysis treatment device is in a strip shape, and in the using state, the ultrasonic thrombolysis treatment device is spirally wound around the outer wall of a blood vessel section (100) where thrombus is located; or the ultrasonic thrombolysis treatment device is formed into a plane shape, the ultrasonic thrombolysis treatment device wraps the outer wall of the blood vessel section (100) in the using state, the ultrasonic thrombolysis treatment device comprises a plurality of piezoelectric modules (200) which are arranged in a scattered mode, the piezoelectric modules (200) can be controlled to emit ultrasonic waves, and the ultrasonic thrombolysis treatment device is used for treating the blood vessel section (100). The ultrasound is enabled to be emitted from a plurality of locations in a focused manner into the vessel section (100) to ablate the thrombus.

Description

Technical Field

[0001] The present application relates to the field of ultrasonic therapy, and in particular to an ultrasonic thrombolytic therapy device. Background Art

[0002] Ultrasound thrombolysis is a treatment method that uses ultrasound technology to dissolve blood clots in blood vessels. Ultrasound is applied to the blood clots to accelerate the dissolution of the blood clots through the mechanical action of sound waves. Ultrasound thrombolysis has the advantages of rapid dissolution and low risk, so it is often used to treat cardiovascular diseases such as myocardial infarction or stroke.

[0003] The existing ultrasonic thrombolytic therapy device makes a hole and punctures the blood vessel, inserts a catheter into the human blood vessel, and then uses the catheter to guide the ultrasonic therapy probe to the thrombus site inside the blood vessel, and then emits ultrasonic waves through the ultrasonic therapy probe to ablate the thrombus. This type of thrombolytic device requires the catheter to move a long distance in the human blood vessel to reach the thrombus site, which greatly increases the difficulty of operation and seriously reduces the patient's comfort. And due to the narrow space inside the blood vessel, the volume of the probe in the ultrasonic thrombolytic device is usually very small, which seriously reduces its energy power for ultrasonic thrombolytic therapy. The catheter inserted into the blood vessel not only significantly reduces the patient's comfort, but also affects the body's normal blood circulation. In severe cases, it will cause serious secondary trauma to the blood vessels, bringing great risks to the operation. Summary of the invention

[0004] In order to solve or alleviate at least one of the problems mentioned in the background technology, the present application provides an ultrasonic thrombolytic therapy device.

[0005] The ultrasonic thrombolytic therapy device provided in the embodiment of the present application is formed into a strip shape. When in use, the ultrasonic thrombolytic therapy device is spirally coiled around the outer wall of the blood vessel segment where the thrombus is located; or the ultrasonic thrombolytic therapy device is formed into a planar shape. When in use, the ultrasonic thrombolytic therapy device is wrapped around the outer wall of the blood vessel segment. The ultrasonic thrombolytic therapy device includes a plurality of piezoelectric modules disposed in a dispersed manner. The piezoelectric modules can emit ultrasonic waves in a controlled manner, so that the ultrasonic waves can be emitted into the blood vessel segment in a focused manner from a plurality of positions to ablate the thrombus.

[0006] In at least one embodiment, the ultrasonic thrombolytic therapy device is formed into a strip shape, and the therapy device includes a shape memory material substrate that carries the multiple piezoelectric modules, and the shape memory material substrate is configured to be able to autonomously spirally coil and conformally adhere to the outer wall of the blood vessel segment under thermal drive of body temperature.

[0007] In at least one embodiment, the ultrasonic thrombolytic therapy device is formed in a strip shape, and the plurality of piezoelectric modules are arranged on the therapy device in a linear array, and the piezoelectric modules are connected via flexible interconnecting wires.

[0008] In at least one embodiment, the flexible interconnecting wire is configured to be able to stretch and retract at least in an extension direction of the ultrasonic thrombolytic therapy device.

[0009] In at least one embodiment, the ultrasonic thrombolytic therapy device is formed into a strip shape, and the relationship between the pitch and width of the ultrasonic thrombolytic therapy device is configured such that, in a state of use, the blood vessel segment is exposed between two adjacent spiral segments of the ultrasonic thrombolytic therapy device.

[0010] In at least one embodiment, the treatment device is formed into a planar shape, and in a state of use, the piezoelectric modules are disposed on two opposite sides of the blood vessel segment in a circumferential direction, so that the thrombus can receive ultrasonic waves transmitted from opposite directions.

[0011] In at least one embodiment, the treatment device is formed into a planar shape, and the multiple piezoelectric modules are arranged in a planar array on the treatment device. The piezoelectric modules are connected via flexible interconnect wires, and the flexible interconnect wires include a spiral extension structure, so that the two ends of a flexible interconnect wire can adjust their relative positions in the axial direction of the spiral extension structure and in the radial direction of the spiral extension structure.

[0012] In at least one embodiment, the therapeutic device has a planar configuration, and the flexible interconnect wires between the piezoelectric modules extend along a first direction or along a second direction, and the first direction is perpendicular to the second direction.

[0013] In at least one embodiment, the ultrasonic thrombolytic therapy device includes: a matching module, which is arranged on the side of the piezoelectric module facing the blood vessel segment, and is used to adjust the acoustic impedance matching effect of the piezoelectric module and the blood vessel segment; a power supply module, which is used to supply power to the piezoelectric module; and a packaging layer, which is used to encapsulate each module in the ultrasonic thrombolytic therapy device.

[0014] In at least one embodiment, the piezoelectric module is fixed relative to the packaging layer, so that the ultrasonic wave emission angle of the piezoelectric module is determined by the attachment angle of the packaging layer to the blood vessel segment.

[0015] The treatment device provided in the present application does not require puncturing of the blood vessel, and can emit ultrasonic waves from outside the blood vessel to inside the blood vessel to ablate the blood clots in the blood vessel. There is no need to use a longer catheter to guide inside the blood vessel. According to clinical needs, the treatment device can be directly aimed (spirally coiled or wrapped) at the blood vessel segment where the thrombus is located, avoiding trauma to the vascular system and improving safety and patient comfort. The spiral coiling or wrapping method can fix the treatment device to the blood vessel around the entire circumference of the blood vessel, and the dispersed piezoelectric modules enable multiple angles on the circumference of the blood vessel to be affected by ultrasonic waves, which has a good ultrasonic focusing effect and high thrombolysis efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 A schematic diagram of an ultrasonic thrombolytic therapy device according to Embodiment 1 of the present application is shown.

[0017] Figure 2 A schematic diagram showing the use status of the ultrasonic thrombolytic therapy device according to the first embodiment of the present application.

[0018] Figure 3 A schematic diagram of an ultrasonic thrombolytic therapy device according to the second embodiment of the present application is shown.

[0019] Description of Reference Numerals 100 blood vessel segments 200 Piezoelectric Module 300 Shape memory material substrate 400 Flexible Interconnect Wire 410 Extension Structure 500 Helical Segments 600 matching modules 700 Power Module 800 Encapsulation Layer DETAILED DESCRIPTION

[0020] The exemplary embodiments of the present application are described below with reference to the accompanying drawings. It should be understood that these specific descriptions are only used to teach those skilled in the art how to implement the present application, and are not intended to exhaust all possible methods of the present application, nor to limit the scope of the present application.

[0021] The present application provides an ultrasonic thrombolytic therapy device (hereinafter, sometimes referred to as a "therapy device"). Figure 1 , Figure 2 The treatment device can be formed into a strip shape. When in use, the treatment device is spirally wound around the outer wall of the blood vessel segment 100 where the thrombus is located. Alternatively, see Figure 3 The treatment device is formed into a planar shape. In the use state, the treatment device can be wrapped around the outer wall of the blood vessel segment 100.

[0022] The treatment device may include a plurality of dispersed piezoelectric modules 200, which can controllably emit ultrasound waves, so that ultrasound waves can be focusedly emitted from multiple positions into the blood vessel segment 100 to ablate thrombi. The piezoelectric module 200 may include a piezoelectric transducer to emit ultrasound waves.

[0023] On the one hand, the treatment device provided by the present application does not need to puncture the blood vessel, and can emit ultrasonic waves from outside the blood vessel to the inside of the blood vessel to ablate the thrombus in the blood vessel. In addition, the present application does not need to use a long catheter to guide the blood vessel, and can directly aim (spirally coil or wrap) the treatment device at the blood vessel segment where the thrombus is located according to clinical needs, avoiding trauma to the vascular system, and improving safety and patient comfort.

[0024] On the other hand, the applicant is aware of a method of fixing the ultrasonic device on one side of the part to be treated, and then adjusting the spatial angle of the piezoelectric module through a microactuator to focus the ultrasonic waves. This method is obviously more suitable for organs with larger volumes and relatively smaller autonomous deformations. Moreover, the design of setting it on one side of the part to be treated will also increase the difficulty of fixing the ultrasonic treatment device and increase the difficulty of focusing the ultrasound.

[0025] For blood vessels, which are small and have subtle movements, the concept of adjusting the spatial angle of the piezoelectric module is complex and difficult to implement. The present application proposes a method of fixing the treatment device to the blood vessel by spiral winding or wrapping around the entire circumference of the blood vessel. The dispersed piezoelectric modules enable multiple angles on the circumference of the blood vessel to be affected by ultrasound, resulting in good ultrasound focusing effect and high thrombolysis efficiency.

[0026] Below, this application introduces each embodiment in detail.

[0027] Embodiment 1

[0028] See also Figure 1 , Figure 2 , the treatment device is formed into a strip.

[0029] In one example, the therapeutic device includes a shape memory material substrate 300 carrying a plurality of piezoelectric modules 200. The shape memory material substrate 300 is configured to be able to spirally coil autonomously and conformally adhere to the outer wall of the blood vessel segment 100 under thermal drive of body temperature.

[0030] The shape memory material has good mechanical flexibility and can be spirally coiled along the outer wall of the blood vessel under the thermal drive of body temperature. The shape memory material makes the attachment between the treatment device and the blood vessel closer and the ultrasonic transmission efficiency is high, thus making the ultrasonic-based thrombolytic therapy more efficient. The shape memory material can be a shape memory polymer. Figure 2 In the embodiment, after the shape memory material substrate 300 is deformed, the treatment device can be closely attached to the blood vessel segment 100 .

[0031] In one example, a plurality of piezoelectric modules 200 are arranged in a linear array on the treatment device, and the piezoelectric modules 200 are connected via flexible interconnect wires 400. More specifically, a treatment device may have a row of piezoelectric modules 200. Its shape allows the width of the treatment device to be smaller (the width of the treatment device is slightly larger than the piezoelectric module), which facilitates the implementation of the spiral winding shape.

[0032] In one example, the flexible interconnect wire 400 is configured to be able to stretch at least in the extension direction of the treatment device. Thus, after the blood vessel moves slightly, the piezoelectric module 200 can move accordingly to avoid damaging the blood vessel.

[0033] In one example, the relationship between the pitch and width of the treatment device is configured such that, in the use state, a blood vessel segment 100 is exposed between two adjacent spiral segments 500 of the treatment device. The spiral arrangement of the present application is relatively loose, with a larger pitch and a smaller width, and the treatment device does not affect the normal activity of the blood vessel, thereby avoiding damage to the blood vessel.

[0034] Embodiment 2

[0035] See also Figure 3 , the treatment device is formed into a surface shape.

[0036] In one example, a plurality of piezoelectric modules 200 are arranged in a planar array on the treatment device. In use, piezoelectric modules 200 are arranged on opposite sides of the vascular segment 100 in the circumferential direction, so that the thrombus can be affected by ultrasound waves transmitted from opposite directions, thereby improving the focusing effect of ultrasound waves and enhancing the treatment efficiency.

[0037] In one example, each piezoelectric module 200 is connected via a flexible interconnect wire 400, which includes a spiral extension structure 410, so that the two ends of a flexible interconnect wire 400 can adjust their relative positions in the axial direction of the spiral extension structure 410 and in the radial direction of the spiral extension structure 410.

[0038] It should be understood that the spiral extension structure 410 is a three-dimensional spiral with strong deformation and adhesion capabilities, so that the treatment device can still maintain stable treatment performance when a large deformation occurs. The three-dimensional spiral structure can adapt to the deformation process of the treatment device wrapped around the blood vessel and has better ductility in space. When the treatment device wrapped on the outer wall of the blood vessel undergoes a large deformation with the blood vessel segment 100, the three-dimensional spiral structure can withstand most of the strain through its own deformation modes such as elongation and bending, thereby reducing the strain borne by the functional element, thereby achieving protection for the functional element.

[0039] In one example, when the therapeutic device is in a planar configuration, the interconnecting wires between the piezoelectric modules 200 extend along a first direction A or along a second direction B, and the first direction A is perpendicular to the second direction B, so that the surface array is roughly in a grid shape.

[0040] In addition, for the above two embodiments, the treatment device may include a matching module 600 , a power module 700 and a packaging layer 800 .

[0041] The matching module 600 is disposed on the side of the piezoelectric module 200 facing the blood vessel segment 100, and is used to adjust the acoustic impedance matching effect of the piezoelectric module 200 and the blood vessel segment 100, so as to minimize the loss of the sound wave on the interface, thereby increasing the intensity of the ultrasonic wave entering the blood vessel. The matching module 600 can be made of materials such as silica gel.

[0042] The power module 700 is used to supply power to the piezoelectric module 200, thereby being able to drive the piezoelectric module 200 to generate ultrasonic waves.

[0043] The encapsulation layer 800 is used to encapsulate each module in the treatment device. The encapsulation layer 800 may include a flexible organic material with good flexibility and biocompatibility, and its elastic modulus may be close to that of human vascular tissue. The encapsulation layer 800 can protect each module and improve the durability of the treatment device. The encapsulation layer 800 can also prevent each component from irritating or damaging vascular tissue and improve biocompatibility.

[0044] The present application integrates and packages the modules through flexible interconnect wires 400 and packaging layers 800, so that the treatment device has good mechanical flexibility and biocompatibility, thereby avoiding damage to blood vessels.

[0045] In one example, the piezoelectric module 200 is fixed relative to the packaging layer 800, so that the ultrasonic emission angle of the piezoelectric module 200 is determined by the attachment angle between the packaging layer 800 and the blood vessel segment 100. The present application does not need to set a microactuator for adjusting the spatial angle of the piezoelectric module 200 alone, and the structure is relatively simple, avoiding electromagnetic interference of the microactuator.

[0046] In addition, the treatment device in the second embodiment may not be provided with a shape memory material substrate, for example, a common flexible substrate may be provided or the packaging layer 800 may directly package the piezoelectric module 200. An adhesive material may be provided outside the packaging layer 800 to fix the position of the treatment device in the blood vessel segment 100.

[0047] The above is a preferred embodiment of the present application. It should be pointed out that for those skilled in the art, several improvements and modifications can be made without departing from the principles of the present application. These improvements and modifications should also be regarded as the scope of protection of the present application.

Claims

1. An ultrasonic thrombolytic therapy device, characterized in that: The ultrasonic thrombolytic therapy device is formed into a strip shape, and in a state of use, the ultrasonic thrombolytic therapy device is spirally coiled around the outer wall of the blood vessel segment (100) where the thrombus is located; or the ultrasonic thrombolytic therapy device is formed into a planar shape, and in a state of use, the ultrasonic thrombolytic therapy device is wrapped around the outer wall of the blood vessel segment (100). The ultrasonic thrombolytic therapy device comprises a plurality of dispersedly arranged piezoelectric modules (200), wherein the piezoelectric modules (200) are capable of controlling the emission of ultrasonic waves, so that ultrasonic waves can be emitted from a plurality of positions into the blood vessel segment (100) in a focused manner to ablate the thrombus.

2. The ultrasonic thrombolytic therapy device according to claim 1, characterized in that: The ultrasonic thrombolytic therapy device is formed into a strip shape, and comprises a shape memory material substrate (300) that carries the plurality of piezoelectric modules (200), wherein the shape memory material substrate (300) is configured to be able to autonomously spirally coil and conformally adhere to the outer wall of the blood vessel segment (100) under thermal drive of body temperature.

3. The ultrasonic thrombolytic therapy device according to claim 1, characterized in that: The ultrasonic thrombolytic treatment device is formed in a strip shape, the plurality of piezoelectric modules (200) are arranged on the treatment device in a linear array, and the piezoelectric modules (200) are connected via flexible interconnecting wires (400).

4. The ultrasonic thrombolytic therapy device according to claim 3, characterized in that: The flexible interconnecting wire (400) is configured to be able to stretch and retract at least in the extension direction of the ultrasonic thrombolytic therapy device.

5. The ultrasonic thrombolytic therapy device according to claim 1, characterized in that: The ultrasonic thrombolytic therapy device is formed into a strip shape, and the relationship between the pitch and the width of the ultrasonic thrombolytic therapy device is configured such that, in a state of use, the blood vessel segment (100) is exposed between two adjacent spiral segments (500) of the ultrasonic thrombolytic therapy device.

6. The ultrasonic thrombolytic therapy device according to claim 1, characterized in that: The treatment device is formed into a planar shape. When in use, the piezoelectric modules (200) are arranged on two opposite sides of the blood vessel segment (100) in a circumferential direction, so that the thrombus can receive ultrasonic waves transmitted from opposite directions.

7. The ultrasonic thrombolytic therapy device according to claim 1, characterized in that: The treatment device is formed into a planar shape, the plurality of piezoelectric modules (200) are arranged on the treatment device in a planar array, the piezoelectric modules (200) are connected via a flexible interconnection wire (400), the flexible interconnection wire (400) comprises a spiral extension structure (410), so that the two ends of a flexible interconnection wire (400) can adjust their relative positions in the axial direction of the spiral extension structure (410) and in the radial direction of the spiral extension structure (410).

8. The ultrasonic thrombolytic therapy device according to claim 7, characterized in that: The therapeutic device has a planar configuration, and the flexible interconnecting wires (400) between the piezoelectric modules (200) extend along a first direction (A) or along a second direction (B), wherein the first direction (A) is perpendicular to the second direction (B).

9. The ultrasonic thrombolytic therapy device according to claim 1, characterized in that: The ultrasonic thrombolytic therapy device comprises: A matching module (600), arranged on a side of the piezoelectric module (200) facing the blood vessel section (100), and used to adjust the acoustic impedance matching effect of the piezoelectric module (200) and the blood vessel section (100); A power module (700), used to supply power to the piezoelectric module (200); The packaging layer (800) is used to package each module in the ultrasonic thrombolytic therapy device.

10. The ultrasonic thrombolytic therapy device according to claim 9, characterized in that: The piezoelectric module (200) is fixed relative to the packaging layer (800), so that the ultrasonic wave emission angle of the piezoelectric module (200) is determined by the attachment angle between the packaging layer (800) and the blood vessel segment (100).

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