Device and method for separating calcium L-5-methyltetrahydrofolate

Abstract

The invention relates to the field of separation, in particular to a calcium L-5-methyltetrahydrofolate separation device and method.The calcium L-5-methyltetrahydrofolate separation device comprises a hollow reaction kettle, a treatment bin and a separation bin are connected into the reaction kettle and communicate with each other through a connecting pipeline, and a separator used for filtering and separating mixed liquid is arranged in the separation bin; the intermittent rotation of the driving rotating shaft is controlled, so that the whole equipment does not need to be shut down when a filter sheet at any filter cartridge is replaced, the continuous operation time of the equipment is prolonged, the production efficiency of the equipment is improved, and the equipment is convenient to operate through the cooperation of the transmission shaft, the bevel gear and the synchronous belt. The synchronous rotation of the driving rotating shaft, the transmission shaft and the driving rotating shaft is realized, the coordination of stirring, filtering and discharging is ensured, and the overall operation efficiency is improved.

Description

Technical Field

[0001] The invention relates to the field of separation, and in particular to a device and method for separating L-5-methyltetrahydrofolate calcium. Background Art

[0002] L-5-Methyltetrahydrofolate calcium is an important folic acid derivative, widely used in medicine, food additives and nutritional supplements. Due to its high bioavailability and stability, the market demand is increasing. In order to improve the purity and yield of L-5-methyltetrahydrofolate calcium, it is of great significance to develop an efficient separation device. The existing process for separation and extraction of L-5-methyltetrahydrofolate calcium usually includes key steps such as pretreatment of plant raw materials, activation synthesis, and enzymatic separation, among which the separation and purification link is particularly complex. Traditional separation methods rely on physical or chemical means, which are prone to problems such as long process flow, high energy consumption and low processing efficiency.

[0003] With the development of science and technology, technicians in related fields have also made a lot of optimizations on the technical means for separating and extracting L-5-methyltetrahydrofolate calcium. In order to make a more accurate comparison, for example, Chinese patent No. CN114130097A discloses a purification method and device for preparing L-5-methyltetrahydrofolate calcium, including a chassis, a solution tank, a filtration assembly, a filter paper switching device and a liquid receiving tank; when in use, the filter paper is automatically replaced through the cooperation between the telescopic device and the filter paper switching device, without the need for manual replacement by operators, and in addition, the switched filter paper roll is directly scraped off the crystal material by the scraper plate when it is rolled on the roller body, thereby realizing the process of automatic unloading; the structural design of the entire filtration device is novel and its degree of automation is high, and it can realize the efficient industrial purification and processing of L-5-methyltetrahydrofolate calcium, and the actual use effect is very excellent.

[0004] However, the above technical means for separating and purifying L-5-methyltetrahydrofolate calcium still have the following shortcomings in actual use: The device lifts the solution tank up and down through the telescopic device and sets the filter paper on the filter paper and pulls it through the winding motor. After each filtration of a certain amount is completed, the solution tank is lifted up so that the clamping ring is separated from the support tray, and the filter paper roll is extended from the strip-shaped opening through the action of the winding motor. At this time, the circular filter disc of the next station above the filter paper roll is just between the clamping ring and the support tray. When the filtration operation is performed again, the telescopic device can be directly controlled to press the solution tank down, thereby realizing automatic replacement of the filter paper. However, when the filter paper in the device needs to be replaced, the solution tank needs to be driven upward by the telescopic device to separate the clamping ring from the support tray before the filter paper can be replaced. That is, whenever the filter paper needs to be replaced, the solution tank needs to be driven upward as a whole, so that the process of separating and purifying L-5-methyltetrahydrofolate calcium is suspended for a period of time until the filter paper switching is completed, which greatly reduces the efficiency of industrial separation and purification of L-5-methyltetrahydrofolate calcium.

[0005] Therefore, under the above-stated viewpoint, there is still room for improvement in the existing technical means for separating and purifying L-5-methyltetrahydrofolate calcium. Summary of the invention

[0006] In order to solve the above problems, the present invention provides an L-5-methyltetrahydrofolate calcium separation device, comprising a reactor with a hollow interior, a processing chamber and a separation chamber connected to the reactor, the processing chamber and the separation chamber are connected by a connecting pipe, and a separator for filtering and separating a mixed liquid is provided in the separation chamber.

[0007] Preferably, the separator comprises an active rotating shaft limitedly disposed on the separation bin, a separation cylinder is coaxially connected between the active rotating shaft and the connecting pipe, the separation cylinder is connected to the connecting pipe, and a plurality of filter cylinders are evenly connected circumferentially on the separation cylinder.

[0008] Preferably, a driving shaft is provided through the middle of the processing chamber, and the driving shaft is connected to a stirring frame limitedly located in the processing chamber.

[0009] Preferably, two ends of the same filter cylinder are symmetrically connected with driven rotating rods, and driven gears are sleeved on the driven rotating rods. All driven gears on the same side of the separation cylinder are meshed with an adjustment gear limitedly located in the separation chamber.

[0010] Preferably, the filter cartridge is limit-connected to the separation cartridge, and an opening is provided on the filter cartridge to communicate with the separation cartridge, and a filter plate is limit-connected on one side of the filter cartridge away from the opening to filter and separate the mixed liquid entering the separation cartridge and the filter cartridge.

[0011] Preferably, a discharge channel is formed at the lower side of the separation bin, a guide plate is rotatably connected to the discharge channel, and the guide plate and the separation cylinder are connected by a torsion spring.

[0012] Preferably, the filter plate is in an arc-shaped structure and fits on the filter cartridge, an extension block embedded on the filter cartridge is symmetrically connected to the filter plate, and a clamping ring for limiting the extension block is symmetrically connected between the separation cartridge and the filter cartridge.

[0013] Preferably, a snap-fit ​​groove is formed on the filter cartridge at a position corresponding to the extension block, and the extension block and the filter cartridge are commonly connected to a return spring limitedly located in the snap-fit ​​groove.

[0014] Preferably, a liquid outlet channel is formed at the lower side of the separation chamber, and a collecting chamber is provided at a position corresponding to the liquid outlet channel in the reaction kettle so as to collect and process the filtered mixed liquid.

[0015] In addition, the present invention also provides a method for separating L-5-methyltetrahydrofolate calcium, which uses a specific separation device for purification and separation, and the separation method comprises the following steps: S1. Take an appropriate amount of L-5-methyltetrahydrofolate calcium crude material, put it into deionized water, heat and stir until it is evenly mixed with the deionized water, and then perform ultrasonic treatment.

[0016] S2. The mixed solution after ultrasonic treatment is heated to reflux.

[0017] S3, placing the mixed solution after heating and reflux into a reactor for filtration and separation, and then drying the separated crystals to obtain refined L-5-methyltetrahydrofolate calcium.

[0018] In summary, the present application includes at least one of the following beneficial technical effects: 1. The present invention controls the intermittent rotation of the active shaft, and can replace the filter sheet at any filter cartridge without shutting down the entire equipment, thereby improving the continuous operation time and production efficiency of the equipment. The synchronous rotation of the driving shaft, the transmission shaft and the active shaft is achieved through the cooperation of the transmission shaft, the bevel gear and the synchronous belt, ensuring the coordinated operation of stirring, filtering and discharging, and improving the overall operating efficiency.

[0019] 2. The present invention drives the separation cylinder and the filter cylinder to rotate intermittently through the active rotating shaft, thereby avoiding the long-term accumulation of crystals in the filter cylinder, thereby effectively preventing the filter holes from being blocked, and then the filter cylinder is rotated and adjusted relative to the separation cylinder by cooperating with the driven gear, thereby further preventing the accumulation of crystals, and through the cooperation between the guide plate and the separation cylinder, the filtered crystals in the filter cylinder are discharged during the rotation of the filter cylinder, so as to be subsequently dried.

[0020] 3. The present invention can effectively retain crystals through the filter holes evenly distributed on the filter cartridge, while allowing the aqueous solution to pass through, ensuring separation efficiency. The filter plate is tightly fitted on the filter cartridge through the cooperation between the clamping ring, the return spring and the extension block, further improving the filtration accuracy and facilitating the replacement of the filter plate. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The present invention is further described below in conjunction with the accompanying drawings and embodiments.

[0022] Figure 1 It is a schematic structural diagram of the separation device of the present invention.

[0023] Figure 2 It is a schematic diagram of the cross-sectional structure of the reactor of the present invention.

[0024] Figure 3 It is a schematic structural diagram of the separator of the present invention.

[0025] Figure 4 It is a schematic diagram of the structure of the discharge channel of the present invention.

[0026] Figure 5 It is a schematic structural diagram of the filter sheet of the present invention.

[0027] Figure 6 It is a structural schematic diagram of the adjusting gear of the present invention.

[0028] Figure 7 It is a structural schematic diagram of the guide plate of the present invention.

[0029] Figure 8 It is a schematic structural diagram of the filter cartridge of the present invention.

[0030] Fig. 9 The present invention Figure 8 Enlarged image of .

[0031] Fig.10 It is a flow chart of the steps of the method of the present invention.

[0032] In the figure, 10, reactor; 11, processing chamber; 12, separation chamber; 13, connecting pipe; 14, separator; 140, driving shaft; 141, separation cylinder; 142, filter cylinder; 143, driving shaft; 144, stirring frame; 15, driven rotating rod; 150, driven gear; 151, adjusting gear; 16, opening; 160, filter plate; 161, discharge channel; 162, guide plate; 163, transmission shaft; 164, bevel gear; 17, extension block; 170, clamping ring; 171, engaging groove; 172, reset spring; 18, liquid outlet channel; 19, collecting chamber. DETAILED DESCRIPTION

[0033] The following is combined with Figures 1 to 10Embodiments of the present invention are described in detail.

[0034] The embodiment of the present application discloses an L-5-methyltetrahydrofolate calcium separation device and method, which illustrates that the present application is mainly used in the process of separating and purifying L-5-methyltetrahydrofolate calcium, and technically realizes the effect of separating and extracting L-5-methyltetrahydrofolate calcium from a mixed solution containing L-5-methyltetrahydrofolate calcium. In particular, during the separation process, the mutual cooperation between the rotating separation cylinder and the filter cylinder effectively avoids the problem of excessive accumulation of L-5-methyltetrahydrofolate calcium after filtration and separation in the filter cylinder and the separation cylinder, resulting in clogging of the filter holes thereon. Furthermore, the present application also realizes the intermittent rotation of the separation cylinder by driving the mutual cooperation between the bevel gears between the rotating shaft and the transmission shaft, and dynamically adjusts the position of the filter cylinder on the separation cylinder, so as to replace the filter sheet on the filter cylinder while ensuring the continuous extraction and separation of L-5-methyltetrahydrofolate calcium.

[0035] Embodiment 1, refer to Figure 1 As shown, a L-5-methyltetrahydrofolate calcium separation device includes a hollow reactor 10, a processing chamber 11 and a separation chamber 12 are connected to the reactor 10, the processing chamber 11 and the separation chamber 12 are connected through a connecting pipe 13, and a separator 14 for filtering and separating the mixed solution is provided in the separation chamber 12. When in use, the heated mixed solution is introduced into the processing chamber 11, and then introduced into the separation chamber 12 through the connecting pipe 13, and then the mixed solution entering the separation chamber 12 is filtered and separated by the separator 14, so as to separate the L-5-methyltetrahydrofolate calcium crystals precipitated in the mixed solution, and finally the separated crystals are dried to obtain refined L-5-methyltetrahydrofolate calcium.

[0036] It should be noted that L-5-methyltetrahydrofolate calcium crude liquid is prepared from L-5-methyltetrahydrofolate crude material and deionized water under certain temperature conditions, and the impurities separated by the present application are mostly L-5-methyltetrahydrofolate that is not completely reacted or dissolved in the L-5-methyltetrahydrofolate calcium crude liquid, calcified salt (usually calcium chloride) and related reaction by-products.

[0037] Reference Figure 3As shown, the separator 14 includes an active rotating shaft 140 which is limitedly penetrated on the separation chamber 12, and a separation cylinder 141 is coaxially connected between the active rotating shaft 140 and the connecting pipe 13. The separation cylinder 141 is connected to the connecting pipe 13, and a plurality of filter cylinders 142 are evenly connected circumferentially on the separation cylinder 141. When in use, the mixed liquid is introduced into the separation cylinder 141 through the connecting pipe 13, and the mixed liquid flows into the filter cylinder 142 connected to the separation cylinder 141, and is separated therefrom, so that the crystals precipitated in the mixed liquid remain in the filter cylinder 142, and the remaining aqueous solution is discharged outward through the filter cylinder 142, so as to achieve the effect of separating and extracting the crystals precipitated in the mixed liquid.

[0038] Reference Figure 3 As shown, in order to increase the crystallization rate of the mixture in the processing chamber 11, a driving shaft 143 is provided in the middle of the processing chamber 11, and the driving shaft 143 is connected to a stirring frame 144 limitedly located in the processing chamber 11. When in use, the driving shaft 143 and the stirring frame 144 are driven to rotate by the existing motor technology to drive the mixed liquid in the processing chamber 11 to shift, increase the fluidity of the mixed liquid, and help L-5-methyltetrahydrofolate calcium crystals to crystallize out from the mixed liquid.

[0039] As an optional embodiment, a heating jacket may be mounted on the outside of the processing chamber 11. By cooperating with the heating jacket and the stirring frame 144, the temperature in the preparation process can be effectively regulated to increase the crystallization efficiency of L-5-methyltetrahydrofolate calcium.

[0040] Reference Figure 3As shown, the two ends of the same filter cartridge 142 are symmetrically connected with a driven rotating rod 15, and a driven gear 150 is sleeved on the driven rotating rod 15. All the driven gears 150 on the same side of the separation cartridge 141 are meshed with an adjustment gear 151 limitedly located in the separation chamber 12. When in use, by driving the active rotating shaft 140 to rotate, the active rotating shaft 140 drives the separation cartridge 141 and the plurality of filter cartridges 142 on the separation cartridge 141 to rotate synchronously, and the rotation of the filter cartridge 142 drives the connected driven rotating rod 15 and the driven gear 150 to rotate, so that a relative rotation effect is formed between the driven gear 150 and the adjustment gear 151. At this time, the adjustment gear 151 limits the meshing driven gear 150, drives the driven gear 150, the driven rotating rod 15 and the connected filter cartridge 142 to rotate, so that the filter cartridge 142 A relative rotation effect is formed between the separation cylinder 141, that is, all the filter cylinders 142 rotate synchronously with the separation cylinder 141, and are also driven to rotate and adjust around the driven rotating rod 15 as the axis through their respectively connected driven rotating rods 15 and driven gears 150. The rotating filter cylinders 142 and the separation cylinder 141 prevent any filter cylinder 142 on the separation cylinder 141 from staying in the same position for a long time, which may easily cause excessive accumulation of precipitated crystals on the upper side to block the filter holes on the filter cylinder 142, and then affect the subsequent filtering and separation effect of the mixed liquid.

[0041] Reference Figure 3 As shown, the filter cartridge 142 is rotatably connected to the separation cartridge 141, and an opening 16 is provided on the filter cartridge 142 to be connected to the separation cartridge 141. A filter sheet 160 is limitedly connected to one side of the filter cartridge 142 away from the opening 16, and a plurality of filter holes are evenly provided on the filter sheet 160 to filter and separate the mixed liquid entering the separation cartridge 141 and the filter cartridge 142. When in use, after the mixed liquid introduced into the separation cartridge 141 flows to the filter cartridge 142, the opening 16 on any one of the filter cartridges 142 is driven to be connected to the separation cartridge 141 accordingly, so that the L-5-methyltetrahydrofolate calcium crystals precipitated in the mixed liquid are retained in the filter cartridge 142, and then the separation cartridge 141 and all the filter cartridges 142 are driven to rotate synchronously to avoid the problem that too many L-5-methyltetrahydrofolate calcium crystals filtered out from the same filter cartridge 142 are accumulated on each other, resulting in the problem that the filter holes on the filter sheet 160 are blocked and affect the subsequent filtering and separation efficiency.

[0042] Further, refer to Figure 3As shown, in order to facilitate the discharge of L-5-methyltetrahydrofolate calcium crystals remaining in the filter cylinder 142 after filtration for subsequent drying treatment, a discharge channel 161 is formed on the lower side of the separation bin 12, and a guide plate 162 is rotatably connected to the discharge channel 161. The guide plate 162 and the separation cylinder 141 are connected by a torsion spring. A collection box for collecting the discharged L-5-methyltetrahydrofolate calcium crystals is also provided on the reactor 10. In the initial state, the guide plate 162 is driven by the torsion spring to be inclined against the outer side of the separation cylinder 141. After the separation cylinder 141 and the plurality of filter cylinders 142 are driven to rotate, the rotating filter cylinder 142 will push the guide plate 162 to deflect downward so that the torsion spring is further deformed. In this process, the end of the guide plate 162 close to the filter cylinder 142 will be pressed against the filter sheet 160, and with the rotation and displacement of the filter cylinder 142 and the filter sheet 160, the outer side of the filter sheet 160 is scraped to prevent the precipitated small particles from adhering to the filter sheet 160 and affecting the subsequent filtering effect. When the filter cylinder 142 rotates, After passing over the guide plate 162, the guide plate 162 is driven by the deformed torsion spring to rest against the separation cylinder 141 again. At this time, one of the filter cylinders 142 and the filter plate 160 that have rotated over the guide plate 162 is driven by the connected driven rotating rod 15 and the driven gear 150, and rotates with the driven rotating rod 15 as the axis, and the opening 16 on the filter cylinder 142 is rotated to face the discharge channel 161, so that the crystals filtered and separated in the filter cylinder 142 fall to the guide plate 162, and then are discharged outward along the guide plate 162, completing the collection of L-5-methyltetrahydrofolate calcium crystals for subsequent drying treatment.

[0043] Furthermore, in order to drive the filter cartridge 142 to rotate at the discharge channel 161 to discharge the filtered crystals therein while rotating with the separation cartridge 141, the adjustment gear 151 is set as an incomplete gear, so that the driven rotating rod 15 and the driven gear 150 connected to the filter cartridge 142 only rotate at the discharge channel 161, and then reset to communicate with the separation cartridge 141, thereby avoiding leakage of the filtered crystals in the filter cartridge 142.

[0044] As an optional embodiment, a transmission shaft 163 is also connected in the reactor 10 and is arranged parallel to the driving shaft 140. The transmission shaft 163 and the driving shaft 143 are connected via a bevel gear 164, and the transmission shaft 163 and the driving shaft 140 are connected via a synchronous belt transmission to achieve a synchronous rotation effect between the driving shaft 143, the transmission shaft 163 and the driving shaft 140.

[0045] Furthermore, any one of the two bevel gears 164 between the transmission shaft 163 and the driving shaft 143 is set as an incomplete bevel gear 164, so as to realize the effect of continuously driving the driving shaft 143 to rotate and intermittently driving the transmission shaft 163 and the active shaft 140 to rotate. The driving shaft 143 drives the connected stirring frame 144 to rotate continuously, so as to realize the effect of promoting the precipitation efficiency of the mixed liquid in the processing chamber 11. By intermittently driving the active shaft 140 to rotate, the active shaft 140 drives the separation cylinder 141 and several filter cylinders 142 to rotate intermittently, so as to realize the effect of increasing the filtration efficiency of the filter cylinder 142.

[0046] Reference Figure 3 As shown, the filter sheet 160 is in an arc-shaped structure and fits on the filter cartridge 142. The filter sheet 160 is symmetrically connected with an extension block 17 embedded in the filter cartridge 142. A clamping ring 170 for limiting the extension block 17 is symmetrically connected between the separation cartridge 141 and the filter cartridge 142. When in use, when the separation cartridge 141 and all the filter cartridges 142 are driven to rotate, the extension block 17 connected to both ends of the filter sheet 160 on the filter cartridge 142 is limited and compressed by the clamping ring 170, so that the extension block 17 and the filter sheet 160 fit tightly on the filter cartridge 142, so as to achieve the effect of separating and filtering out the crystals precipitated in the mixed liquid.

[0047] Further, refer to Figure 3 As shown, in order to facilitate the removal and replacement of the filter plate 160 limited on the filter cartridge 142, the clamping ring 170 is an arc-shaped shape with a notch, and a snap-fit ​​groove 171 is formed on the filter cartridge 142 corresponding to the extension block 17. The extension block 17 and the filter cartridge 142 are commonly connected with a return spring 172 limitedly located in the snap-fit ​​groove 171. It should be noted that one end of the return spring 172 is limitedly connected in the snap-fit ​​groove 171, and the other end is abutted against the extension block 17 so as to be disengaged from the extension block 17. During normal use, the return spring 172 is limitedly compressed in the snap-fit ​​groove 171 and has a tendency to always protrude outward from the connected snap-fit ​​groove 171 so as to drive the extension block 17 and the filter plate 160 to separate from the connected filter cartridge 142. When in use, when the separation cylinder 141, the filter cylinder 142, the filter plate 160 and the extension block 17 are driven to rotate, the extension block 17 and the filter plate 160 are pressed and limited on the connected filter cylinder 142 through the clamping ring 170. When any one of the filter cylinder 142, the connected filter plate 160 and the extension block 17 rotates to the notch section at the clamping ring 170, the compressed reset spring 172 drives the connected extension block 17 and the filter plate 160 to slide away from the separation cylinder 141, thereby facilitating the subsequent replacement of the filter plate 160.

[0048] At the same time, since the separation cylinder 141 and all the filter cylinders 142 rotate intermittently back and forth, the filter sheet 160 at any one of the filter cylinders 142 can be replaced by controlling the intermittent rotation of the active rotating shaft 140 without stopping the entire equipment, thereby effectively improving the efficiency of separating L-5-methyltetrahydrofolate calcium.

[0049] Of course, when there is no need to remove the filter plate 160 for replacement, a limiting slide concentric with the clamping ring 170 can be detachably connected to the notch section of the clamping ring 170 to avoid accidental separation of the filter plate 160 and the filter cartridge 142 during normal use, thereby affecting subsequent filtration and separation.

[0050] Reference Figure 3 As shown, a liquid outlet channel 18 is formed at the lower side of the separation chamber 12, and a collecting chamber 19 is provided in the reaction kettle 10 at a position corresponding to the liquid outlet channel 18, so as to collect and process the filtered mixed liquid.

[0051] When the above separation device is used to separate L-5-methyltetrahydrofolate calcium, the separation method comprises the following steps: S1. Take an appropriate amount of L-5-methyltetrahydrofolate calcium crude material, put it into deionized water, heat and stir until it is evenly mixed with the deionized water, and then ultrasonically treat it for 15 minutes.

[0052] S2. Heating the mixed solution after ultrasonic treatment to at least 50° C. (preferably between 50° C. and 60° C.) for reflux.

[0053] S3, placing the mixed solution after heating and refluxing into the reaction kettle 10 for filtration and separation, and then drying the separated crystals at a temperature of 60° C. to obtain refined L-5-methyltetrahydrofolate calcium.

[0054] It is obvious to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the present invention can be implemented in other specific forms without departing from the spirit or essential features of the present invention. Therefore, the embodiments should be considered as exemplary and non-restrictive in all respects.

[0055] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A L-5-methyltetrahydrofolate calcium separation device, characterized in that: The invention comprises a reactor (10) with a hollow interior, wherein a processing chamber (11) and a separation chamber (12) are connected to the reactor (10), the processing chamber (11) and the separation chamber (12) are connected via a connecting pipe (13), and a separator (14) for filtering and separating a mixed liquid is arranged in the separation chamber (12).

2. A L-5-methyltetrahydrofolate calcium separation device according to claim 1, characterized in that: The separator (14) comprises a driving shaft (140) which is limitedly disposed on the separation chamber (12); a separation cylinder (141) is coaxially connected between the driving shaft (140) and the connecting pipe (13); the separation cylinder (141) is connected to the connecting pipe (13); and a plurality of filter cylinders (142) are evenly connected to the separation cylinder (141) in a circumferential direction.

3. A L-5-methyltetrahydrofolate calcium separation device according to claim 1, characterized in that: A driving shaft (143) is provided through the middle of the processing chamber (11), and the driving shaft (143) is connected to a stirring frame (144) which is located within the processing chamber (11).

4. A L-5-methyltetrahydrofolate calcium separation device according to claim 2, characterized in that: The two ends of the same filter cylinder (142) are symmetrically connected to driven rotating rods (15), and driven gears (150) are sleeved on the driven rotating rods (15). All driven gears (150) on the same side of the separation cylinder (141) are meshed with an adjustment gear (151) limitedly located in the separation chamber (12).

5. A L-5-methyltetrahydrofolate calcium separation device according to claim 2, characterized in that: The filter cartridge (142) is positionally connected to the separation cartridge (141), and an opening (16) is provided on the filter cartridge (142) and is connected to the separation cartridge (141). A filter sheet (160) is positionally connected to a side of the filter cartridge (142) away from the opening (16) so as to filter and separate the mixed liquid entering the separation cartridge (141) and the filter cartridge (142).

6. A L-5-methyltetrahydrofolate calcium separation device according to claim 1, characterized in that: A discharge channel (161) is formed on the lower side of the separation bin (12), and a guide plate (162) is rotatably connected to the discharge channel (161). The guide plate (162) and the separation cylinder (141) are connected via a torsion spring.

7. A L-5-methyltetrahydrofolate calcium separation device according to claim 5, characterized in that: The filter sheet (160) is in an arc-shaped structure and fits on the filter cartridge (142); an extension block (17) embedded in the filter cartridge (142) is symmetrically connected to the filter sheet (160); and a clamping ring (170) for limiting the extension block (17) is symmetrically connected between the separation cartridge (141) and the filter cartridge (142).

8. A L-5-methyltetrahydrofolate calcium separation device according to claim 7, characterized in that: A snap-fit ​​groove (171) is formed on the filter cartridge (142) at a position corresponding to the extension block (17), and a return spring (172) limitedly located in the snap-fit ​​groove (171) is commonly connected between the extension block (17) and the filter cartridge (142).

9. A L-5-methyltetrahydrofolate calcium separation device according to claim 1, characterized in that: A liquid outlet channel (18) is formed at the lower side of the separation chamber (12), and a collection chamber (19) is provided in the reaction kettle (10) at a location corresponding to the liquid outlet channel (18) so as to collect and process the filtered mixed liquid.

10. A method for separating calcium L-5-methyltetrahydrofolate, using a calcium L-5-methyltetrahydrofolate separation device as claimed in any one of claims 1 to 9, characterized in that: The separation method comprises the following steps: S1. Take an appropriate amount of L-5-methyltetrahydrofolate calcium crude material, put it into deionized water, heat and stir until it is evenly mixed with the deionized water, and then perform ultrasonic treatment; S2, heating the mixed solution after ultrasonic treatment to reflux; S3, placing the mixed solution after heating and refluxing into a reaction kettle (10) for filtration and separation, and then drying the separated crystals to obtain refined L-5-methyltetrahydrofolate calcium.

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