Red date and rose cream formula for improving female reproductive health and preparation method of red date and rose cream formula

Abstract

The invention provides a red date and rose cream formula for improving female reproductive health and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following medicinal material components: red dates, roses, mulberries and Chinese wolfberry fruits. The traditional Chinese medicine composition has the main effects of benefiting qi, nourishing blood, tonifying kidney and strengthening essence. The theory of traditional Chinese medicine believes that essence and blood are homologous, essence is enriched, blood is nourished, ovarian blood circulation is good, ovarian functions and normal ovulation are improved, and female reproductive health is maintained. The fructus lycii, the mulberries, the roses and the red dates which are homologous in medicine and food belong to top-grade medicines and are combined to achieve the purposes of beautifying, maintaining the ovary and improving fertility, so that the traditional Chinese medicine composition is a preferred product for maintaining the ovary and deeply beautifying.

Description

Technical Field

[0001] The invention belongs to the field of traditional Chinese medicine, and particularly relates to a red date and rose paste prescription for improving female reproductive health and a preparation method thereof. Background Art

[0002] Women's reproductive health is receiving more and more attention. In addition to Western medicine treatment, the health care effects of traditional Chinese medicine and Chinese herbal medicine are experiencing a deeper level of demand from health to beauty. Traditional Chinese medicine emphasizes overall conditioning, closely linking the face, body, demeanor and temperament with meridians, qi and blood, and comprehensively using acupuncture, internal medicine, diet therapy and other methods to combine the overall regulation of body functions with local repairs such as the face, so as to achieve the purpose of self-cultivation, beauty and skin whitening. Menstruation is an important sign of whether the female reproductive endocrine system is normal. Abnormal menstruation in women is often caused by decreased ovarian function. How to protect ovarian function, maintain normal menstruation and improve female reproductive health is a challenge faced by the reproductive field at home and abroad.

[0003] Ovulation disorders and diminished ovarian reserve (DOR) often lead to abnormal menstruation and reduced fertility. At present, the incidence of DOR in infertile people is about 10%-35%, and it has a trend of increasing year by year and getting younger. How to prevent DOR and maintain ovaries is an issue that we urgently need to solve.

[0004] Ovaries are the root and treasure of women. Ovarian function decline can also be a manifestation of human aging as people age. Ovarian function directly affects reproductive health and pregnancy. Women's health and quality of life are inseparable from reproductive endocrinology.

[0005] Decreased ovarian function leads to estrogen deficiency, which affects women:

[0006] 1) Skin appearance: dry skin, dull skin, sagging and aging, facial spots, reduced elasticity, acne, etc.;

[0007] 2) Affecting the beauty of female body, causing local obesity, fat flowing to the back, causing breast deformation, sagging, loosening and shrinkage;

[0008] 3) It affects women’s teeth and makes them prone to falling out;

[0009] 4) Affects female voices, from the "chanting voice" of adolescence to the calm and capable voice before middle age, and then to the slowness and trembling voice in old age;

[0010] 5) The vagina becomes dry, often accompanied by symptoms such as decreased libido and sexual indifference;

[0011] 6) Dry hair, easy hair loss, and reduced hair luster.

[0012] The number of follicles in a woman's ovaries is fixed at birth due to genetic factors. It will not increase after birth, and it will decrease with age. Women are born with about 2-4 million primordial follicles. As they age, the number of follicles in the ovaries gradually decreases to about 300,000-400,000 during puberty. During sexual maturity, about 300-400 follicles mature and ovulate. Therefore, the female reproductive period is about 30 years. Generally, women are no longer fertile about 5 years before menopause (although menstruation can still be maintained for about 5 years before menopause), and enter the period of ovarian function decline (menopause, perimenopause). In other words, the development and maturation of follicles and ovulation are competitive. About one thousandth of the primordial follicles can mature and ovulate (1 / 1000). We use paste products to increase the ovarian follicle development and maturation rate, so that the competitiveness of follicles increases from 1 / 1000 to 1 / 800-900, which can retain more small follicles, prolong the ovarian ovulation function, delay or postpone the onset of menopause, and keep women young. Although aging is inevitable, it is possible to slow it down.

[0013] The idea of ​​medicine and food having the same origin and preventing illness before it occurs is an important part of the treasure house of traditional Chinese medicine: medicine and food having the same origin means that medicines that have preventive and therapeutic effects on certain diseases have the attributes of food, that is, they have the dual attributes of food and medicine. The ancients advocated the use of food to supplement medicine in order to prolong life.

[0014] Currently, the Chinese patent medicines commonly used in medicine to improve women's reproductive health are not only of few varieties, but also not very targeted. Ovarian function needs to be cared for and maintained. Long-term use of drugs is often accompanied by side effects, making it difficult to sustain the therapeutic effect. How to innovate a daily product for ovarian care and anti-aging to maintain women's menstruation and beauty is a clinical problem that urgently needs to be solved. Summary of the invention

[0015] The purpose of the present invention is to provide a Chinese medicine composition, which adopts the drug-food homology technology with cocktail characteristics to form a functional food-grade Chinese medicine composition.

[0016] The Chinese medicine composition provided by the present invention is prepared from components including the following medicinal materials: red dates, rose flowers, mulberries and wolfberries.

[0017] In the Chinese medicine composition, the mass ratio of red dates, roses, mulberries and wolfberries can be: 10: (5-15): (8-20): (5-15), specifically: 10: (8-12): (10-15): (8-12);

[0018] Furthermore, the components may also include tortoise shell glue; wherein the mass ratio of red dates, roses, mulberries, wolfberries and tortoise shell glue may be: 10: (5-15): (8-20): (5-15): (30-80), specifically: 10: (8-12): (10-15): (8-12): (40-60).

[0019] Furthermore, the components can be the following medicinal materials: red dates, roses, mulberries, wolfberries, tortoise shell glue and crystal sugar.

[0020] Among them, the mass ratio of red dates, roses, mulberries, wolfberries, tortoise shell glue and rock sugar can be: 10: (5-15): (8-20): (5-15): (30-80): (8-20), specifically: 10: (8-12): (10-15): (8-12): (40-60): (12-18).

[0021] Specifically, the mass ratio of red dates, roses, mulberries, wolfberries, tortoise shell glue and crystal sugar can be: 10:10:12:10:50:15.

[0022] In the above-mentioned medicines, each medicinal material can be a Chinese medicinal decoction piece of the corresponding medicinal material, or can be a Chinese medicinal granule prepared from the corresponding Chinese medicinal decoction piece.

[0023] In the above-mentioned drugs, the dosage form of the drug can be a dosage form for gastrointestinal administration or a dosage form for parenteral administration.

[0024] The dosage form for administration via the gastrointestinal tract can be powder, tablet, granule, capsule, pill, solution, emulsion, suspension, paste, oral liquid or tea substitute. The dosage form for administration via the parenteral tract can be injection.

[0025] The preparation method of the above-mentioned drug may include the following 1) or 2) or 3):

[0026] 1) The medicine is prepared by using red dates, roses, mulberries and wolfberries;

[0027] 2) The medicine is prepared by using red dates, roses, mulberries, wolfberries and tortoise shell glue;

[0028] 3) The medicine is prepared by using red dates, roses, mulberries, wolfberries, tortoise shell glue and crystal sugar.

[0029] The method for preparing the drug also belongs to the protection scope of the present invention, and the method comprises the following 1) or 2) or 3):

[0030] 1) The medicine is prepared by using red dates, roses, mulberries and wolfberries;

[0031] 2) The medicine is prepared by using red dates, roses, mulberries, wolfberries and tortoise shell glue;

[0032] 3) The medicine is prepared by using red dates, roses, mulberries, wolfberries, tortoise shell glue and crystal sugar.

[0033] Specifically, the present invention provides a paste prescription of the above-mentioned medicine.

[0034] The paste prescription is prepared by a method comprising the following steps: soaking red dates, roses, mulberries and wolfberries in water, decocting, collecting the Chinese medicine liquid, decocting the filtered residue with water again, collecting the Chinese medicine liquid, combining the two Chinese medicine liquids and concentrating them, adding crushed tortoise shell glue, adding rice wine and rock sugar, and boiling until the liquid is tender.

[0035] In the above method, the mass ratio of red dates, roses, mulberries, wolfberries, tortoise shell glue and crystal sugar can be: 10: (5-15): (8-20): (5-15): (30-80): (8-20), specifically: 10: (8-12): (10-15): (8-12): (40-60): (12-18), more specifically: 10: 10: 12: 10: 50: 15;

[0036] The soaking water is 8-12 times the total mass of the medicinal materials, and specifically can be 10 times;

[0037] The soaking time may be 2-3 hours, specifically 2 hours;

[0038] The decoction time may be 0.5-2h, specifically 1h;

[0039] Add twice the amount of water to the residue and boil for 1 hour;

[0040] The ratio of rice wine to red dates can be 200-300mL:100g; specifically 250mL:100g.

[0041] The use of the above-mentioned traditional Chinese medicine composition in the preparation of a product for improving the reproductive health of a subject (female) also falls within the protection scope of the present invention.

[0042] In the application, the improvement of female reproductive health includes: improving the decline of ovarian reserve function; promoting the restoration of normal menstruation (menstrual volume, color and cycle, etc.); improving the symptoms of menopausal syndrome (including improved sleep, full mood, and high energy); promoting ovarian ovulation; maintaining normal female hormone levels (including normal or restored estrogen (E2) levels, normal or decreased ovarian follicle-stimulating hormone (FSH) levels, and increased AMH values).

[0043] In the application, the subject is a patient with reproductive sub-health who receives acupuncture therapy.

[0044] The acupuncture method used is: select the acupoints Shenque, Zhongji, Guanyuan, uterus, Zusanli, Neiguan, Sanyinjiao, disinfect and insert them to feel the "qi"; use low-frequency 2Hz electroacupuncture to stimulate continuously for 30 minutes; use moxibustion on Shenque; acupuncture from Clean menstruation Initially, use it for about 10 days in a row as a treatment cycle (with 30 minutes of heat therapy using an infrared lamp).

[0045] The main effects of the Chinese medicine composition of the present invention are to invigorate qi and nourish blood, invigorate the kidney and strengthen the essence. According to the theory of traditional Chinese medicine, essence and blood are of the same origin, and invigorating essence can nourish blood. Good ovarian blood circulation can improve ovarian function and normal ovulation, and maintain female reproductive health. Among them, wolfberry is the main medicine: it has the functions of invigorating essence and improving eyesight, replenishing essence and blood to enhance blood quality; and the wolfberry polysaccharide, B-carotene and vitamins in wolfberry can delay aging and directly nourish the skin; rose is the ministerial medicine: it has the functions of promoting qi and blood, promoting blood circulation and unblocking collaterals, helping to regulate blood circulation, making the skin bright and relieving emotions; mulberry is the adjuvant medicine: it has the functions of invigorating blood and nourishing yin. Studies have found that a large amount of vitamin C and anthocyanins are hidden in dried mulberries, which are masters of anti-oxidation and can delay aging; red dates are the enabling medicine with a harmonizing function, and red date polysaccharides help to invigorate blood and qi. Wolfberry, mulberry, rose and red dates, which are both medicinal and edible, are all top-grade medicines. The combination of these four can achieve the purpose of beautifying, maintaining the ovaries and improving fertility. They are the preferred products for maintaining ovaries and deep beauty.

[0046] The main outcome indicators of this project are to improve women's reproductive health, including: normal menstruation (menstrual volume, color and cycle, etc.), effective improvement of menopausal syndrome symptoms; including improved sleep, full mood and energy; secondary outcome indicators are ovarian ovulation (B-ultrasound), normal levels of six female hormones, including normal or normal estrogen (E2), normal or decreased ovarian follicle-stimulating hormone (FSH) levels, increased AMH values, etc. Clinical practice in Guangxi, Beijing, Baotou, Jiaxing, Zhejiang and Shandong has achieved good results for people with abnormal menstruation, decreased ovarian reserve function, ineffective Western medicine ovulation, and elderly people preparing for second child pregnancy. There is a huge market demand for patented drugs that maintain ovarian restoration of normal menstruation and delay aging. Products with strong pertinence, obvious efficacy and no toxic side effects can not only help improve women's reproductive health, but also deeply nourish the skin, and have a large market demand. BRIEF DESCRIPTION OF THE DRAWINGS

[0047] Figure 1 These are the laboratory test results of polycystic ovary syndrome of the patient in Example 3.

[0048] Figure 2 B-ultrasound indicates that the patient's follicles are mature and ovulating.

[0049] Figure 3 The patient's urine pregnancy test was (+).

[0050] Figure 4 The patient's blood HCG level was 577, indicating a normal pregnancy. DETAILED DESCRIPTION

[0051] The present invention is further described in detail below in conjunction with specific embodiments, and the examples provided are only for illustrating the present invention, rather than for limiting the scope of the present invention. The examples provided below can be used as a guide for further improvements by those of ordinary skill in the art, and do not constitute a limitation of the present invention in any way.

[0052] The experimental methods in the following examples, unless otherwise specified, are conventional methods and are performed according to the techniques or conditions described in the literature in the art or according to the product instructions.

[0053] Unless otherwise specified, the materials and reagents used in the following examples can be obtained from commercial sources.

[0054] The acupuncture method used in the following embodiments is: select the acupoints Shenque, Zhongji, Guanyuan, uterus, Zusanli, Neiguan, Sanyinjiao, routinely disinfect and insert the needle to get the "qi" feeling. Use low-frequency 2Hz electroacupuncture for continuous stimulation for 30 minutes. Shenque is moxibustioned. Acupuncture from Clean menstruation Initially, use it for about 10 days in a row as a treatment cycle (with 30 minutes of heat therapy using an infrared lamp).

[0055] Example 1

[0056] Prepare the paste according to the following prescription:

[0057] 100g red dates, 100g rose, 120g mulberry, 100g wolfberry, 500g tortoise shell glue

[0058] Soak red dates, roses, mulberries and wolfberries in 10 times the amount of water for 2 hours, decoct for 1 hour, collect the medicinal liquid, add 2 times the amount of water to the residue and decoct for 1 hour, collect the medicinal liquid, pool the two medicinal liquids together and concentrate them, add crushed tortoise shell glue, then add 250ml of rice wine and 150g of rock sugar, boil until it is thick, and then package (20ml for a small bag).

[0059] The reason for not using rice wine to soak glue is that first, it is time-consuming, and second, the glue is not soaked thoroughly under the natural temperature in winter, and it is easy to cause the pot to become sticky and not smooth when put into the pot. Therefore, the glue is crushed by a crusher and added to the Chinese medicine liquid, and stirred in time to make it blend into the medicine liquid as much as possible.

[0060] Example 2: Red Date Rose Paste Recipe for Improving Female Reproductive Health

[0061] 1. Research subjects

[0062] A total of 525 female patients with menstrual disorders, manifested as menstrual disorders including decreased or increased menstrual volume, shortened or prolonged menstrual cycle and other symptoms, were randomly divided into two groups: 207 cases in the control group (acupuncture treatment), with an average age of 39.2 years; 318 cases in the experimental group (red dates and rose flower paste + acupuncture treatment), with an average age of 38.8 years.

[0063] 2. Treatment

[0064] Each course of treatment is one menstrual cycle (approximately 28-35 days), and 3 courses are required in succession.

[0065] Experimental group: (Red Date Rose Paste + Acupuncture Treatment) Red Date Rose Paste was taken with warm water once in the morning and evening, one pack (20ml) each time, starting from the 5th day of menstruation, and continued for 10 days; Acupuncture treatment (same method as acupuncture group) started from the end of menstruation, selected acupoints such as Shenque, Zhongji, Guanyuan, Uterus, Zusanli, Neiguan, Sanyinjiao, etc., routinely disinfected and inserted to get the "qi" feeling. Use low-frequency electroacupuncture 2Hz to stimulate continuously for 30 minutes. And with infrared baking lamp for 30 minutes of heat therapy; Shenque was moxibustioned. 10 consecutive days as a course of treatment.

[0066] Control group: (acupuncture group): Select acupoints Shenque, Zhongji, Guanyuan, uterus, Zusanli, Neiguan, Sanyinjiao, and sterilize them routinely before piercing to get a "qi" feeling. Use low-frequency electroacupuncture at 2Hz for continuous stimulation for 30 minutes. Use moxibustion on Shenque. Acupuncture starts from the end of menstruation, and is used for 10 consecutive days as a treatment cycle (with 30 minutes of heat therapy with infrared lamps).

[0067] At the end of each course of treatment, i.e. before the next menstruation, the patient's symptoms were recorded: such as improved sleep, normal menstruation, improved mood, improved quality of sexual life, mental state and follicle maturation and ovulation (B-ultrasound), laboratory tests: increased number of antral follicles, normal or decreased FSH, increased AMH, etc. According to the modified Kupperman scoring standard, the results were markedly effective (<=6 points); effective (7-14 points) and ineffective (>=15 points). The outcome indicators of this study were improved female reproductive health, including: normal menstruation (menstrual volume, color and cycle, etc.), effective improvement of symptoms: including improved sleep, full mood, energetic, etc. The more courses of treatment, the better the effect.

[0068] The results showed that after three courses of treatment, the effective rate of the experimental group was 88%, and that of the control group was 76%. There was a significant difference after statistical analysis (p<0.01), indicating that the efficacy of the experimental group (red dates and rose paste + acupuncture treatment group) was significantly higher than that of the control group (simple acupuncture treatment group), see Table 1.

[0069] In the experimental group (red date rose flower paste + acupuncture treatment), there were 69 cases aged 21-25 years, including 50 cases of marked effect, 15 cases of effective, and 4 cases of ineffectiveness; there were 70 cases aged 26-30 years, including 49 cases of marked effect, 17 cases of effective, and 4 cases of ineffectiveness; there were 58 cases aged 31-35 years, including 40 cases of marked effect, 15 cases of effective, and 3 cases of ineffectiveness; there were 47 cases aged 36-40 years, including 32 cases of marked effect, 11 cases of effective, and 4 cases of ineffectiveness; there were 36 cases aged 41-45 years, including 19 cases of marked effect, 8 cases of effective, and 9 cases of ineffectiveness; there were 38 cases aged 46-50 years, including 17 cases of marked effect, 8 cases of effective, and 13 cases of ineffectiveness. In the age group, the red date rose flower paste was more effective in the group <=40 years old (21-40) than in the group >40 years old (41-50) (P<0.01). However, there was no statistically significant difference among the 21-25, 26-30, 31-35 and 36-40 age groups (P>0.05). See Table 2.

[0070] Table 1. The therapeutic effect of red date rose paste prescription on improving female reproductive health

[0071]

[0072] P<0.01

[0073] Table 2. The therapeutic effect of the red date rose paste prescription on improving the reproductive health of women of different age groups

[0074]

[0075] Note 1: In Table 2, the red dates and rose flower paste prescription had a better therapeutic effect in the age group <=40 years old (21-40) than in the age group >40 years old (41-50) (P<0.01). However, there was no statistical significance among the 21-25 years old group, the 26-30 years old group, the 31-35 years old group and the 36-40 years old group (P>0.05).

[0076] Note 2: In Tables 1 and 2, markedly effective treatment means: systemic symptoms are significantly improved. Menstruation can come on a monthly basis (28-45 days), sleep improves, mental and emotional state improves, sexual life improves, B-ultrasound tests show follicle maturation and ovulation; FSH value decreases or AMH value increases. Effective treatment: systemic symptoms are significantly improved, but laboratory tests show no significant improvement. Ineffective treatment: systemic symptoms are not significantly improved, menstruation does not change, and laboratory results do not change, such as no significant decrease in FSH value or change in AMH. With a normal modified Kupperman score (<=6 points), systemic symptoms basically disappear; effective treatment: modified Kupperman score is slightly higher (7-14 points), systemic symptoms are significantly improved; ineffective treatment: modified Kupperman score is high (>15 points), and systemic symptoms are not significantly improved.

[0077] The results showed that when the Chinese medicine ointment of Example 1 was used to improve female reproductive health, the percentage of the treatment group that improved female reproductive health reached 88%, and statistically compared with the control group (76%), it had a significant therapeutic effect (p<0.01). The percentage of those with a therapeutic effect between 21 and 25 years old reached 94.2%, the percentage of those with a therapeutic effect between 26 and 30 years old reached 94.2%, the percentage of those with a therapeutic effect between 31 and 35 years old reached 94.8%, the percentage of those with a therapeutic effect between 36 and 40 years old reached 91.5%, the percentage of those with a therapeutic effect between 41 and 45 years old reached 75%, and the percentage of those with a therapeutic effect between 46 and 50 years old reached 65.8%. The data in Table 2 were converted to X 2 The test method was used for analysis, and it was found that there was no significant difference in the percentage of patients with the same treatment effect in different age groups of 21-40 years (p>0.05), indicating that the Chinese medicine ointment can improve the reproductive health of women. Statistical analysis of patients showed that the Chinese medicine ointment of the present invention can be used to treat and improve the reproductive health of women.

[0078] Example 3

[0079] The Chinese medicine ointment prescription of Example 1 of the present invention treated a patient with amenorrhea for 5 months, and the patient became pregnant naturally after menstruation was restored and successfully delivered a baby boy at full term. The mother and child are healthy. The report is as follows:

[0080] 1 Clinical Data

[0081] The patient, female, 28 years old, was treated at Zhejiang Jiaxing Yuecheng Obstetrics and Gynecology Hospital in October 2023 due to "missing menstruation for 5 months". Self-report: Since the beginning of 2022, menstruation has been delayed and cannot come on time. Sometimes menstruation comes only once every 2-3 months. Oral progesterone drugs are used to regulate menstruation. Menstruation comes when taking the medicine and stops when stopping the medicine. Menstruation has not come since June and has lasted for more than 5 months. Now she has symptoms such as irritability, mood swings, dry skin, low libido, etc., and she has gained 5 kilograms of weight due to oral progesterone drugs. She strongly requires Chinese medicine and acupuncture to regulate menstruation and refuses to take Western medicine. She has a history of polycystic disease ( Figure 1 ). There is no special medical history.

[0082] Outpatient examination: The patient was in poor spirits and had a bad complexion. Physical examination: Generally good, T36.5; P61; BP106 / 60mgHg; R20 times. No abnormality in the heart, liver, lungs, and kidneys. Laboratory examination: AMH4; LH / FSH>2( Figure 1 ).

[0083] Diagnosis: 1. Secondary amenorrhea; 2. Polycystic ovary syndrome.

[0084] Treatment plan: According to the patient's special situation, we use a cocktail of assisted reproductive technology therapy, precision acupuncture + the one-stop technology therapy of the Chinese medicine ointment prescription of Example 1 of the present invention to treat this amenorrhea patient. We formulate a personalized cocktail technology therapy for her:

[0085] The Chinese medicine ointment prepared in Example 1 starts from D5, twice a day, 20 ml each time, for 10 consecutive days, which is a treatment cycle. Precision acupuncture method: select acupoints Shenque, Zhongji, Guanyuan, uterus, Zusanli, Neiguan, Sanyinjiao, routinely disinfect and insert to get a "qi" feeling. Use low-frequency electroacupuncture 2Hz for continuous stimulation for 30 minutes. Use moxibustion on Shenque. Acupuncture starts from D5-D7 when the menstruation is over, and is used for about 10 consecutive days, which is a treatment cycle. One menstrual cycle regulates and restores ovarian function ( Figure 2 ).

[0086] After the cocktail therapy (paste prescription + acupuncture) maintains the ovaries and restores menstruation, the consolidation treatment is continued for 2 menstrual cycles, and ovulation is detected to maintain a normal menstrual cycle.

[0087] After 2 months of treatment, menstruation came naturally. In the 3rd month, I started to prepare for pregnancy. In the 4th month, I got pregnant successfully (successfully in January 2024 (see Figure 3 ) Full-term delivery of a mature male baby.

[0088] The present invention has been described in detail above. For those skilled in the art, without departing from the purpose and scope of the present invention, and without the need to carry out unnecessary experimental conditions, the present invention can be implemented in a wide range under equivalent parameters, concentrations and conditions. Although the present invention provides specific embodiments, it should be understood that the present invention can be further improved. In a word, according to the principles of the present invention, the application is intended to include any changes, uses or improvements to the present invention, including departure from the disclosed scope in the application, and changes made with conventional techniques known in the art.

Claims

1. A Chinese medicine composition prepared from the following medicinal materials: red dates, rose flowers, mulberries and wolfberries.

2. The Chinese medicine composition according to claim 1, characterized in that: In the traditional Chinese medicine composition, the mass proportions of red dates, roses, mulberries and wolfberries are: 10: (5-15): (8-20): (5-15) respectively.

3. The Chinese medicine composition according to claim 1, characterized in that The components also include tortoise shell glue; wherein the mass proportions of red dates, roses, mulberries, wolfberries and tortoise shell glue are: 10: (5-15): (8-20): (5-15): (30-80) respectively.

4. The Chinese medicine composition according to claim 3, characterized in that: The components are the following medicinal materials: red dates, roses, mulberries, wolfberries, tortoise shell glue and crystal sugar; Among them, the mass ratio of red dates, roses, mulberries, wolfberries, tortoise shell glue and rock sugar is: 10: (5-15): (8-20): (5-15): (30-80): (8-20).

5. The Chinese medicine composition according to claim 4, characterized in that: The mass ratio of red dates, roses, mulberries, wolfberries, tortoise shell glue and rock sugar is 10:10:12:10:50:

15.

6. Use of the Chinese medicine composition according to any one of claims 1 to 5 in the preparation of a product for improving the reproductive health of a subject (female).

7. The use according to claim 6, characterized in that: The improvement of female reproductive health includes: improving the decline of ovarian reserve function; promoting the restoration of normal menstruation; improving the symptoms of menopausal syndrome (including improved sleep, good mood, and high energy); promoting ovarian ovulation; maintaining normal female hormone levels (including normal or restored normal estrogen (E2) levels, normal or decreased ovarian follicle-stimulating hormone (FSH) levels, and increased AMH values).

8. The use according to claim 6, characterized in that: In the application, the subject is a patient with reproductive sub-health who receives acupuncture therapy.

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