Traditional Chinese medicine and Mongolian medicine formula for treating sores and ulcers and burns and scalds

Abstract

The invention relates to a traditional Chinese medicine and Mongolian medicine formula for treating sores, ulcers, burns and scalds, which is composed of 10 medicinal materials such as scutellaria baicalensis, angelica sinensis and pseudo-ginseng, and a synergistic system of clearing heat and drying dampness, cooling and activating blood, nourishing blood and stopping bleeding and relieving swelling and pain is formed through optimized compatibility. Lithospermum erythrorhizon and dragon's blood synergistically promote the growth rate of granulation tissues to be increased by 40%, and angelica polysaccharide and notoginsenoside Rg1 increase the microvascular density by 2.3 times. The preparation process adopts a gradient extraction-emulsification coupling technology: two-stage decoction at 60 DEG C to 80 DEG C enables the extraction rate of effective components to reach 92%, badger fat (the total mass of decoction pieces is 25-50%) is added in batches, and high-speed shearing (300-500 rpm) is combined to form a nano-emulsion (the particle size is 2-5 microns), so that the transdermal absorption rate is increased by 3-5 times; the beeswax is subjected to vacuum melting (70-80 DEG C) to form a beta-type crystal structure, the hardness of the paste is 0.8-1.2 kg / cm < 3 >, and 92% of thermosensitive components are still retained after the paste is stored at 40 DEG C for 6 months. The treatment effects of efficient transdermal, rapid repair and long-acting antibiosis are realized.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine and Mongolian medicine, and in particular to a Chinese and Mongolian medicine formula for treating sores and burns. Background Art

[0002] Existing burn treatment drugs have problems such as poor tissue permeability, easy sensitization, and obvious scarring after healing. Although traditional Mongolian medicine ointments have the effect of promoting tissue regeneration, they have defects such as complex ingredients and unstable preparation process. The present invention optimizes the compatibility of Chinese and Mongolian medicinal materials and combines a specific extraction process to develop a compound preparation that has the functions of anti-inflammatory, promoting healing, and reducing scar formation. Summary of the invention

[0003] In order to solve the problems of the prior art, the invention provides a Chinese and Mongolian medicine formula for treating sores and burns.

[0004] In order to solve the above technical problems, the present invention is achieved through the following technical solutions: In the first aspect, a Chinese and Mongolian medicine formula for treating sores and burns is prepared from the following raw materials in parts by weight: 6-8 parts of Scutellaria baicalensis, 4-6 parts of Angelica sinensis, 6-8 parts of Panax notoginseng, 6-10 parts of Borneolum, 4-6 parts of Phellodendron chinense, 8-10 parts of Myrrh, 6-8 parts of Lithospermum officinale, 6-8 parts of Sophora flavescens, 8-12 parts of Lithospermum officinale, and 4-10 parts of Scorpio saussurea.

[0005] Preferably, it is prepared from the following raw materials in parts by weight: 6 parts of Scutellaria baicalensis, 6 parts of Angelica sinensis, 8 parts of Panax notoginseng, 10 parts of Borneolum, 6 parts of Phellodendron chinense, 10 parts of Myrrha, 6 parts of Licorice, 8 parts of Sophora flavescens, 10 parts of Lithospermum officinale, and 8 parts of Scorpio saussurea.

[0006] In this aspect, Scutellaria baicalensis + Phellodendron amurense: the combination of two yellows forms a heat-clearing and dampness-drying matrix. Modern research shows that it contains ingredients such as baicalin and berberine, which have an inhibition rate of more than 78% on common pathogenic bacteria such as Staphylococcus aureus and Escherichia coli, effectively controlling wound infection.

[0007] Lithospermum officinale + blood scorpion: construct a blood-cooling and blood-activating system. The synergistic effect of shikonin and blood scorpion total flavonoids can promote the growth rate of granulation tissue on the wound surface by 40% and accelerate the epithelialization process.

[0008] Functional synergy network

[0009] Angelica + Panax notoginseng: They form a pair that nourishes blood and stops bleeding. Angelica polysaccharide and Panax notoginseng saponin Rg1 work together to increase the microvascular density on the wound surface by 2.3 times, significantly improving local microcirculation.

[0010] Myrrh + Sophora flavescens: form a combination of swelling and pain relief. Bisabolene and matrine synergistically inhibit COX-2 expression, reducing the level of inflammatory factor TNF-α by 65%, effectively relieving pain and swelling.

[0011] Special functional ingredients

[0012] Borneol: As a transdermal enhancer, it can increase the transdermal absorption rate of other drugs by 3-5 times. It also has a local cooling and anesthetic effect, quickly relieving burning pain on the wound.

[0013] Licorice: It plays a role in harmonizing various medicines. Glycyrrhizic acid can enhance the stability of other ingredients. It also has hormone-like anti-inflammatory effects and reduces drug irritation.

[0014] In a second aspect, a method for preparing a Chinese and Mongolian medicine formula for treating sores and burns comprises the following:

[0015] S1: Use a rice washing basket to wash and filter the ten medicinal pieces of Scutellaria baicalensis, Angelica sinensis, Panax notoginseng, Borneolum, Phellodendron amurense, Myrrha, Licorice, Sophora flavescens, Lithospermum officinale, and Scorpio sanguisorba officinalis;

[0016] S2: Place the washed and filtered medicinal pieces in a medicine boiling pot and add clean water to the same level as the medicinal pieces;

[0017] S3: Cook over low heat until the pieces become soft, keeping the water and pieces in the pot;

[0018] S4: Add badger oil to the pot. When the oil returns to its original color from turbidity and the water content of the slices decreases, switch to low heat and continue stirring.

[0019] S5: Remove from heat and filter when the large slices turn yellow and the small slices turn black;

[0020] S6: Melt and filter the beeswax, then add it to the medicinal oil and continue stirring until a paste is formed.

[0021] Preferably, the temperature of decocting on medium-low heat in S3 is 60-80° C., the time is 30-40 minutes, and the decoction pieces are decocted until the water content is reduced to 40-50%, and a small amount of water is kept at the bottom of the pot.

[0022] Preferably, the mass of badger oil added in S4 is 25-50% of the total mass of the washed and filtered slices, and is added in 2-3 times, with an interval of 5-10 minutes between each addition.

[0023] Preferably, the filtration in S5 is performed using a 200-300 mesh screen and is performed at a temperature of 60-70°C.

[0024] Preferably, the amount of beeswax added in S6 is 15-25% of the mass of the medicinal oil, and the beeswax is melted at 70-80° C. in advance and filtered through a 100-mesh filter cloth.

[0025] Preferably, in S6, the stirring speed is 300-500 rpm, the stirring time is 10-15 minutes, and the paste is cooled to 40-50° C. before filling.

[0026] In this aspect, the gradient extraction technique

[0027] Low-temperature decoction at 60-80℃: Using gradient heating technology, first extract at 60℃ for 30 minutes to release water-soluble components, then heat to 80℃ for 10 minutes to destroy cell walls and release fat-soluble components, thereby increasing the extraction rate of total effective ingredients.

[0028] Badger Oil Fusion Process

[0029] Add in batches: Use 25-50% badger oil gradient addition method, control the drug particle size to 2-5μm through high-speed shear force (300-500 rpm), form a stable O / W emulsion, and significantly improve the transdermal efficiency

[0030] Beeswax curing system

[0031] 70-80℃ melting filtration: Vacuum melting technology is used to make beeswax and medicinal oil form a β-type crystal structure, and the hardness of the paste at room temperature reaches 0.8-1.2kg / cm 2 , which not only ensures the applicability but also has good sealing properties, which can reduce water evaporation.

[0032] Key points of quality control

[0033] 200-300 mesh dynamic filtration: combined with 60-70℃ heat preservation technology, the particle size of impurities in the drug oil is reduced to <75μm, ensuring that the preparation is uniform and delicate. Clinical application shows that it can reduce the incidence of irritation reactions.

[0034] The beneficial effects of the present invention are:

[0035] 1. Through the superposition of the triple action mechanism of "immediate analgesia-mid-term repair-long-term anti-scarring", a multi-target treatment system is formed: borneol and beeswax work together to achieve 15 minutes of rapid analgesia and reduce the duration of pain by 58%, baicalin combined with shikonin inhibits IL-6 secretion by 63% and accelerates granulation tissue formation by 3.2 days, and blood scorpion total flavonoids regulate the TGF-β1 / Smad pathway to reduce scar hyperplasia by 45%; at the same time, an alkaloid matrix (MIC up to 0.0625mg / mL) and terpenoid compounds are constructed to synergize the antibacterial network, which increases the inhibition rate of drug-resistant bacteria by 3 times, destroys the biofilm structure and reduces the adhesion rate of Pseudomonas aeruginosa by 89%;

[0036] 2. Adopting gradient extraction-emulsification coupling technology, the extraction rate of effective ingredients is increased by 41% compared with the traditional method through two-stage decoction at 60℃→80℃, combined with badger oil batch high-speed shearing (300-500rpm) to form nanoemulsion (particle size 2.8μm), and the transdermal absorption rate reaches 3.2μg / cm 2 h (increased by 2.8 times); the intelligent curing system forms a β-type crystal structure by melting beeswax in a vacuum at 75°C, and maintains a hardness of 0.9-1.1 kg / cm2 after being stored at 40°C for 6 months 2It retains 92% of the heat-sensitive components, and the dynamic filtration technology reduces the impurity content to less than 0.03%. The clinical irritation reaction rate is only 0.9% (7.3% in the control group). DETAILED DESCRIPTION

[0037] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0038] Embodiment 1: a kind of preparation of Chinese and Mongolian medicine formula for treating sores and burns.

[0039] Raw material composition (parts by weight):

[0040] Scutellaria baicalensis 6g, Angelica sinensis 6g, Panax notoginseng 8g, Borneol 10g, Phellodendron chinense 6g, Myrrha 10g, Licorice root 6g, Sophora flavescens 8g, Lithospermum officinale 10g, Blood scorpion 8g.

[0041] Preparation steps:

[0042] Pretreatment of medicinal materials: Place the above-mentioned pieces in a rice washing basket and quickly wash with running water for 30 seconds to remove the dust on the surface;

[0043] Gradient decoction:

[0044] Decoction at 60℃ for 30 minutes, keeping the water level level with the slices;

[0045] Heat to 80℃ and boil for 10 minutes, at which time the water content of the slices is 45%;

[0046] Badger Oil Fusion:

[0047] Add 40% of the total weight of the slices of badger oil (52 g) in 3 times, with an interval of 8 minutes between each addition;

[0048] Keep stirring at 300 rpm, and observe that the oil changes from turbid to amber transparent;

[0049] Dynamic Filtering:

[0050] Use a 250-mesh stainless steel screen to filter at 65°C;

[0051] The solid content of the filtrate was 18.7% after testing;

[0052] Beeswax Curing:

[0053] Add 20% of the mass of the drug oil, beeswax (32 g), which was pre-melted at 75°C and filtered through a 100-mesh filter cloth;

[0054] Stir at high speed (400 rpm) for 12 minutes to form a paste;

[0055] Cool to 45℃ and fill. The paste hardness test is 1.0kg / cm 2 ;

[0056] Test results:

[0057] Active ingredient content: baicalin 3.2mg / g, berberine 2.8mg / g, shikonin 1.5mg / g;

[0058] Transdermal rate: 3.2μg / cm 2 h (2.8 times higher than traditional technology);

[0059] Antibacterial activity: The MIC value against Staphylococcus aureus is 0.125 mg / mL.

[0060] Example 3: Clinical application verification

[0061] Case selection: 60 patients with second-degree burns were randomly divided into two groups

[0062] Experimental group: using the product of Example 1 (30 cases);

[0063] Control group: used commercially available moist burn ointment (30 cases);

[0064] Treatment results:

[0065] Wound healing time: experimental group (12.5±2.3 days) vs control group (16.7±3.1 days);

[0066] Pain relief time: experimental group (2.1±0.8 hours) vs control group (4.5±1.2 hours);

[0067] Scar incidence: experimental group (6.7%) vs control group (23.3%);

[0068] The positive rate of bacterial culture: experimental group (3.3%) vs control group (16.7%).

[0069] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese and Mongolian medicine formula for treating sores and burns, characterized in that: The drug is prepared from the following raw materials in parts by weight: 6-8 parts of scutellaria baicalensis, 4-6 parts of angelica sinensis, 6-8 parts of notoginseng, 6-10 parts of borneol, 4-6 parts of phellodendron amurense, 8-10 parts of myrrh, 6-8 parts of liquorice, 6-8 parts of sophora flavescens, 8-12 parts of lithospermum officinale, and 4-10 parts of blood scorpion.

2. A Chinese and Mongolian medicine formula for treating sores and burns according to claim 1, characterized in that: 6 parts of Scutellaria baicalensis, 6 parts of Angelica sinensis, 8 parts of Panax notoginseng, 10 parts of Borneolum, 6 parts of Phellodendron chinense, 10 parts of Myrrha, 6 parts of Licorice, 8 parts of Sophora flavescens, 10 parts of Lithospermum officinale, and 8 parts of Scorpio.

3. A method for preparing a Chinese and Mongolian medicine formula for treating sores and burns according to claim 1, characterized in that: Includes the following: S1: Use a rice washing basket to wash and filter the ten medicinal pieces of Scutellaria baicalensis, Angelica sinensis, Panax notoginseng, Borneolum, Phellodendron amurense, Myrrha, Licorice, Sophora flavescens, Lithospermum officinale, and Scorpio sanguisorba officinalis; S2: Place the washed and filtered medicinal pieces in a medicine boiling pot and add clean water to the same level as the medicinal pieces; S3: Cook over low heat until the pieces become soft, keeping the water and pieces in the pot; S4: Add badger oil to the pot. When the oil returns to its original color from turbidity and the water content of the slices decreases, switch to low heat and continue stirring. S5: Remove from heat and filter when the large slices turn yellow and the small slices turn black; S6: Melt and filter the beeswax, then add it to the medicinal oil and continue stirring until a paste is formed.

4. A method for preparing a Chinese and Mongolian medicine formula for treating sores and burns according to claim 3, characterized in that: The temperature of decocting on medium-low heat in S3 is 60-80° C., and the time is 30-40 minutes, and the decoction pieces are decocted until the water content of the decoction pieces decreases to 40-50%, and a small amount of water is kept at the bottom of the pot.

5. A method for preparing a Chinese and Mongolian medicine formula for treating sores and burns according to claim 3, characterized in that: The mass of badger oil added to S4 is 25-50% of the total mass of the washed and filtered slices, and is added in 2-3 times, each time with an interval of 5-10 minutes.

6. A method for preparing a Chinese and Mongolian medicine formula for treating sores and burns according to claim 3, characterized in that: The filtration in S5 is performed using a 200-300 mesh screen and is carried out at a temperature of 60-70°C.

7. A method for preparing a Chinese and Mongolian medicine formula for treating sores and burns according to claim 3, characterized in that: The amount of beeswax added in S6 is 15-25% of the mass of the medicinal oil, and the beeswax is melted at 70-80° C. in advance and filtered through a 100-mesh filter cloth.

8. A method for preparing a Chinese and Mongolian medicine formula for treating sores and burns according to claim 3, characterized in that: In the step S6, the stirring speed is 300-500 rpm, the stirring time is 10-15 minutes, and the paste is cooled to 40-50° C. before filling.