A diet metabolism regulating acne-removing composition suitable for sensitive skin and application thereof

Abstract

The application discloses a diet metabolism regulating anti-acne composition suitable for sensitive skin and application thereof, and relates to the technical field of cosmetics. The application provides a diet metabolism regulating anti-acne composition, which comprises component A and component B; the component A comprises the following components in parts by weight: rehmannia extract 0.1-0.5 parts, radix peucedani extract 0.01-0.2 parts; the component B comprises the following components in parts by weight: 10-hydroxy decanoic acid 0.005-0.3 parts, anthocyanin 0.0005-0.008 parts, guaiacum extract 0.5-3 parts. The diet metabolism regulating anti-acne composition of the application adds rehmannia extract, radix peucedani extract, 10-hydroxy decanoic acid, anthocyanin and guaiacum extract with proper parts by weight, and the five components can synergize with each other, so that the diet metabolism regulating anti-acne composition can regulate water and oil balance, dredge pores, repair skin barrier and improve and prevent acne induced by IGF-1.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of cosmetics, and in particular to a diet metabolism regulating anti-acne composition suitable for sensitive skin and application thereof. BACKGROUND

[0002] Acne is a very common chronic inflammatory or non-inflammatory skin disease in clinical practice, and the onset site is usually located in the area with high density of hair follicle sebaceous gland distribution, such as face, chest and neck, and back. Typical acne manifestations include non-inflammatory lesions such as blackheads, and inflammatory lesions such as pustules, papules or nodules. Insulin-like growth factor (IGF)-1 plays a crucial role in the pathogenesis of acne. Studies have shown that the peripheral blood IGF-1 level of acne patients is elevated, especially under the influence of western dietary habits, which promotes the production of IGF-1, induces sebum secretion, causes pore blockage, aggravates inflammation, and stimulates acne development.

[0003] At present, the existing acne-improving products have the following shortcomings: (1) ignoring the influence of dietary factors on acne: high oil and high fat diet can aggravate acne by increasing insulin and IGF-1 activity, participating in the proliferation of keratinocytes, sebaceous gland cells and fat formation. However, the existing ingredients for improving the influence of dietary metabolism on the skin need to be further explored. (2) the existing ingredients have safety risks: for non-inflammatory acne, there are salicylic acid, benzoyl peroxide, azelaic acid, vitamin A, etc., and for inflammatory acne, antibiotics or other bacteriostatic measures are additionally used. Acne treatment drugs have certain skin side effects and irritation, leading to skin scaling, pigmentation and sensitivity, etc.

[0004] In view of this, the present application is proposed. SUMMARY

[0005] Based on this, the purpose of the present application is to overcome the shortcomings of the prior art and provide a diet metabolism regulating anti-acne composition suitable for sensitive skin and application thereof.

[0006] To achieve the above purpose, the technical solution adopted by the present application is: a diet metabolism regulating anti-acne composition, the composition comprising component A and component B: the component A comprising the following ingredients in parts by weight: rehmannia extract 0.1-0.5 parts, radix peucedani extract 0.01-0.2 parts; the component B comprising the following ingredients in parts by weight: 10-hydroxy decanoic acid 0.005-0.3 parts, anthocyanin 0.0005-0.008 parts, guaiacum extract 0.5-3 parts.

[0007] Rehmannia glutinosa is one of the commonly used bulk medicinal materials. It is mainly produced in Henan, Hebei, Shaanxi and other places. The main components are iridoid, ionone, triterpenoid, etc. It has immunomodulatory and anti-aging effects. Rehmannia extract can regulate the immune system, enhance the immune defense ability of the skin, and prevent the damage of harmful factors (such as bacteria and ultraviolet rays) to the skin. As a newly added medicinal material in Chinese Pharmacopoeia 2010 edition, modern pharmacological studies have shown that the main active ingredient in Radix Anthrisci is coumarin compounds, which has anti-neurasthenia, anti-coagulation, anti-oxidation, anti-bacterial, anti-cancer and other pharmacological activities. Hydroxyl decanoic acid is an important moisturizing agent in the field of cosmetics. It can increase the water content of the skin, improve the moisture and elasticity of the skin, and also has antioxidant and antibacterial effects, which can delay skin aging and protect the skin from bacterial infection. Anthocyanins, as a natural antioxidant ingredient, have been widely used in the field of cosmetics. Its antioxidant, anti-inflammatory, whitening, anti-aging and moisturizing effects make it an important ingredient in various skin care products, anti-aging products and sensitive skin care products. Guaiacum is widely used in traditional medicine, especially in the treatment of skin diseases. Guaiacum contains rich antioxidant ingredients that can effectively scavenge free radicals in the body. It can help restore the skin barrier and promote the skin's self-repair. It can accelerate cell renewal, improve skin metabolism, and enhance the skin's self-protection ability. When the skin is damaged, guaiacum can accelerate the repair and healing process of the damaged area and reduce the formation of scars.

[0008] The inventors found in practical research that Rehmannia extract can be used as a bacteriostatic, anti-inflammatory, oil-controlling and diet-regulating factor in the composition system, and the addition of Radix Anthrisci extract can enhance these effects. After being used together, the prepared composition has better effects on regulating water and oil balance, unblocking pores, repairing skin barrier and improving and preventing acne. 10-hydroxy decanoic acid can be used as a bacteriostatic, anti-inflammatory, oil-controlling and diet-regulating factor in the composition system, and anthocyanins and guaiacum extract can enhance this effect. After being used together, the prepared composition has better effects on regulating water and oil balance, unblocking pores, repairing skin barrier and improving and preventing acne.

[0009] The inventors found in actual research that the addition of the rehmannia extract, the radix magnoliae biflorae extract, 10-hydroxy decanoic acid, anthocyanin, and guaiac extract in the acne-removing composition for regulating dietary metabolism of the present application can synergize with each other, so as to regulate water and oil balance, dredge pores, repair skin barrier, and improve and prevent acne induced by IGF-1. The composition provided by the present application can reduce the content of insulin-like growth factor IGF-1, block the transmission of downstream dietary signals, effectively regulate the secretion of sebum, and reduce the release of cell inflammatory factors; the composition provided by the present application can dredge pores, reduce the formation of comedones, and prevent the occurrence and development of acne; the composition provided by the present application can effectively improve the skin repair capacity, prevent the occurrence of acne marks and pits, and improve the overall skin health.

[0010] Preferably, the component A comprises the following ingredients in the weight parts: rehmannia extract 0.15-0.25 parts, radix magnoliae biflorae extract 0.05-0.15 parts; the component B comprises the following ingredients in the weight parts: 10-hydroxy decanoic acid 0.04-0.1 parts, anthocyanin 0.001-0.005 parts, guaiac extract 0.8-1.5 parts.

[0011] The inventors found in actual research that the weight parts of the components in the composition provided by the present application can affect the performance of the product, and when the weight parts of the components are further selected within the above range, the product obtained has more excellent effects of regulating water and oil balance, dredging pores, repairing skin barrier, and improving and preventing acne induced by IGF-1.

[0012] Preferably, the weight ratio of the component A to the component B is: component A: component B = (0.2-0.4) : (1-1.5).

[0013] Preferably, in the component A, the weight percentage content of the rehmannia extract is 60-70%.

[0014] Preferably, in the component B, the weight percentage content of the 10-hydroxy decanoic acid is 4.5-7.5%.

[0015] The inventors found in actual research that the weight ratio of the component A to the component B in the composition provided by the present application, the weight percentage content of the rehmannia extract in the component A, and the weight percentage content of the 10-hydroxy decanoic acid in the component B can affect the performance of the product, and when the components are further selected within the above range, the product obtained has more excellent effects of regulating water and oil balance, dredging pores, repairing skin barrier, and improving and preventing acne induced by IGF-1.

[0016] Preferably, the preparation method of the rehmannia extract is: taking dried and crushed rehmannia, sieving to obtain rehmannia coarse powder, then adding ethanol solution for ultrasonic extraction, filtering, concentrating and drying the extract to obtain the rehmannia extract.

[0017] Preferably, the volume fraction of the ethanol is 40-90%; further preferably, the volume fraction of the ethanol is 50-60%.

[0018] Preferably, the mesh number of the sieving is 200-400 mesh.

[0019] Preferably, the weight ratio of the ethanol solution to the rehmannia coarse powder is 8-12:1; and / or, the temperature of the ultrasonic extraction is 30-60℃, the time of the ultrasonic extraction is 20-60min, and the extraction times is 1-3 times.

[0020] The inventors found in actual research that the effects of the acne-removing compositions for regulating dietary metabolism prepared by different extraction methods are different when the compositions are added to the acne-removing compositions for regulating dietary metabolism, and the comprehensive effect of the compositions is better when the preparation method is as above.

[0021] In addition, the application provides the use of the acne-removing compositions for regulating dietary metabolism in the preparation of skin products.

[0022] Preferably, the skin product includes any one of the following: cosmetic water, emulsion, cream, paste, cream, essence, spray.

[0023] Further, the application provides a skin product including the acne-removing compositions for regulating dietary metabolism.

[0024] Preferably, the skin product includes the following components by mass percentage: acne-removing compositions for regulating dietary metabolism 1-3%, skin product matrix 3-40%, and water in the remainder.

[0025] Preferably, the skin product matrix includes at least one of the following: thickening agent, humectant, emulsifying agent, preservative, essence, pH regulator.

[0026] Preferably, the skin product includes the following components by mass percentage: acne-removing compositions for regulating dietary metabolism 1-3%, thickening agent 0.05-0.5%, humectant 3-20%, emulsifying agent 0.5-10%, preservative 0.2-5%, essence 0.01-0.2%, pH regulator 0.05-0.1%, and water in the remainder.

[0027] Exemplarily, the thickening agent comprises at least one of xanthan gum, Carbopol 980, AVC, and high-molecular cellulose; the humectant comprises at least one of glycerin, butylene glycol, and low-molecular hyaluronic acid sodium; the emulsifier comprises at least one of coco-caprylate / caprate, dimethicone, hydrogenated palm kernel oil, cetyl stearyl alcohol, polyglyceryl-6 distearate, and methicone; the preservative comprises at least one of 1,3-propanediol, 1,2-hexanediol, and p-hydroxyacetophenone; and the pH regulator comprises at least one of arginine and EDTA-2Na.

[0028] Compared with the prior art, the beneficial effects of the present application are as follows: the inventors have found in actual research that the Rehmannia glutinosa extract can serve as the bacteriostatic, anti-inflammatory, oil-controlling and diet factor IGF-1 regulating performance of the composition system, and the addition of the Peucedanum decursivum extract can enhance these effects, and after being used in combination, the prepared composition has better effects of regulating water and oil balance, unblocking pores, repairing skin barrier and improving and preventing acne induced by IGF-1. The 10-hydroxydecanoic acid can serve as the bacteriostatic, anti-inflammatory, oil-controlling and diet factor IGF-1 regulating performance of the composition system, and the anthocyanin and guaiacwood extract can enhance this effect, and after being used in combination, the prepared composition has better effects of regulating water and oil balance, unblocking pores, repairing skin barrier and improving and preventing acne induced by IGF-1. The inventors have found in actual research that the addition of the Rehmannia glutinosa extract, the Peucedanum decursivum extract, the 10-hydroxydecanoic acid, the anthocyanin and the guaiacwood extract in the acne-removing composition for regulating diet metabolism of the present application in proper proportions can synergize with each other, so as to regulate water and oil balance, unblock pores, repair skin barrier and improve and prevent acne induced by IGF-1. The composition provided by the present application can reduce the content of insulin-like growth factor IGF-1, block the transmission of downstream diet signals, effectively regulate the secretion of sebum and reduce the release of cell inflammatory factors; the composition provided by the present application can unblock pores, reduce the formation of comedones and prevent the occurrence and development of acne; and the composition provided by the present application can effectively improve the skin repair capacity, prevent the occurrence of acne marks and pits and improve the overall skin health. BRIEF DESCRIPTION OF DRAWINGS

[0029] Figure 1 Fig. 2 shows the improvement effect of human facial acne before and after using the product of application example 1 and comparative application example 1 for 14 days, wherein Fig. (a) shows the improvement effect of human facial acne before and after using the product of application example 1 for 14 days, and Fig. (b) shows the improvement effect of human facial acne before and after using the product of comparative application example 1 for 14 days;

[0030] Figure 2Figures for improvement effect of human facial pores before and after 14 days of using the product of application example 1 and comparative application example 1; wherein, figure (c) is a figure for improvement effect of human facial pores before and after 14 days of using the product of application example 1, figure (d) is a figure for improvement effect of human facial pores before and after 14 days of using the product of comparative application example 1. DETAILED DESCRIPTION

[0031] For the purpose of better illustrating the object, technical scheme and advantages of the present application, the present application will be further described below in combination with the drawings and specific examples. The purpose is to understand the content of the present application in detail, rather than to limit the present application. All other examples obtained by the ordinary skilled in the art without making creative efforts belong to the protection scope of the present application. The experimental reagents and instruments designed in the implementation and comparative examples of the present application are all common reagents and instruments unless specifically stated, and can be obtained from commercial channels. In the implementation and comparative examples, the experimental methods used are all conventional methods unless specifically stated, and the raw materials used in parallel experiments are the same batch of raw materials unless specifically stated.

[0032] The raw materials of the present application will be described below, but are not limited to the following raw materials:

[0033] Radix Angelicae Pubescentis extract: purchased from Shaanxi Snot Biological Technology Co., Ltd.;

[0034] 10-hydroxy decanoic acid: purchased from Beijing Solabio Science and Technology Co., Ltd.;

[0035] Anthocyanin: purchased from Shanghai Yuan Ye Biological Technology Co., Ltd.;

[0036] Guaiacwood extract: purchased from Shanghai Yi'en Chemical Technology Co., Ltd.;

[0037] Radix Angelicae Pubescentis extract: purchased from Nanjing Pu Yi Biological Technology Co., Ltd.;

[0038] Aloe extract: purchased from Anhui Bensen Hall Biological Technology Co., Ltd.;

[0039] Anthocyanin: purchased from Shanghai Aladdin Biochem Technology Co., Ltd.;

[0040] Calendula extract: purchased from Guangzhou Mei Yi Biological Technology Co., Ltd.;

[0041] Rehmannia extract-1: self-made, the preparation method is as follows: taking Rehmannia dried and crushed in a 60℃ oven, passing through a 300 mesh sieve to obtain Rehmannia coarse powder, then adding ethanol solution for ultrasonic extraction, suction filtration, concentrating and drying the extract liquid to obtain Rehmannia extract; the volume fraction of the ethanol is 50%, the weight ratio of the ethanol solution to the Rehmannia coarse powder is 8:1, the extraction time is 30 min, the ultrasonic extraction temperature is 40℃, and the extraction times is 2 times.

[0042] Radix Rehmanniae extract-2: self-made, the preparation method is as follows: taking Radix Rehmanniae dried in a 60℃ oven, crushing, and passing through a 300 mesh sieve to obtain Radix Rehmanniae coarse powder; then adding an ethanol solution for ultrasonic extraction, suction filtration, concentrating and drying the extract to obtain the Radix Rehmanniae extract; the volume fraction of the ethanol is 60%, the weight ratio of the ethanol solution to the Radix Rehmanniae coarse powder is 12:1, the extraction time is 60 min, the ultrasonic extraction temperature is 60℃, and the extraction times is 2.

[0043] Radix Rehmanniae extract-3: self-made, compared with Radix Rehmanniae extract-1, only the volume fraction of the ethanol is different, which is 90%.

[0044] Radix Rehmanniae extract-4: self-made, compared with Radix Rehmanniae extract-1, only the volume fraction of the ethanol is different, which is 40%.

[0045] Radix Rehmanniae extract-4: self-made, compared with Radix Rehmanniae extract-1, only the volume fraction of the ethanol is different, which is 40%.

[0046] Radix Rehmanniae extract-4: self-made, compared with Radix Rehmanniae extract-1, only the volume fraction of the ethanol is different, which is 40%.

[0047] Examples and comparative examples

[0048] The examples and comparative examples of the present application provide a diet metabolism regulating acne-removing composition, the components and weight parts of the diet metabolism regulating acne-removing composition are selected as shown in Tables 1-2, and the preparation method of the diet metabolism regulating acne-removing composition comprises the following steps:

[0049] After the Radix Rehmanniae extract, the Radix Saposhnikoviae extract, 10-hydroxy decanoic acid, anthocyanin and the guaiac extract are ultrasonically mixed uniformly, the diet metabolism regulating acne-removing composition is obtained.

[0050] Table 1

[0051]

[0052]

[0053] Table 2

[0054]

[0055]

[0056] Application Example

[0057] The application example provides an emulsion, and components (mass percentage) of the emulsion are shown in Table 3. The diet metabolism regulating and acne-removing composition in application examples 1-9 is respectively prepared by using the diet metabolism regulating and acne-removing composition prepared in examples 1-9, and the diet metabolism regulating and acne-removing composition in comparative application examples 1-9 is respectively prepared by using the diet metabolism regulating and acne-removing composition prepared in comparative examples 1-9; for example, the diet metabolism regulating and acne-removing composition used in application example 1 is the diet metabolism regulating and acne-removing composition prepared in example 1, the diet metabolism regulating and acne-removing composition used in application example 2 is the diet metabolism regulating and acne-removing composition prepared in example 2, the diet metabolism regulating and acne-removing composition used in application example 10 is the diet metabolism regulating and acne-removing composition prepared in example 1, and the diet metabolism regulating and acne-removing composition used in comparative application example 1 is the diet metabolism regulating and acne-removing composition prepared in comparative example 1, and other analogies can be made.

[0058] Table 3

[0059]

[0060] The preparation method of the emulsion provided in application example 1 is as follows:

[0061] (1) The A phase is mixed with water and stirred, heated to 80℃, then homogenized at a speed of 1200 rpm for 5 min, and after homogenization, it is kept warm for standby, and a pre-prepared A phase is obtained;

[0062] (2) The B phase is mixed, heated to 80℃, then homogenized at a speed of 1200 rpm for 5 min, and after homogenization, it is kept warm for standby, and a pre-prepared B phase is obtained;

[0063] (3) The C phase is mixed and melted at 60℃, and a pre-prepared C phase is obtained;

[0064] (4) The pre-prepared A phase is warmed to 80℃, the pre-prepared B phase is added at a speed of 300 rpm, and stirred and mixed, then cooled to 60℃, the pre-prepared C phase is added at a speed of 300 rpm, and stirred and mixed, then cooled to below 45℃, the composition and essence are added, and stirred for 5 min, finally, the arginine is added to adjust the pH to 5.0-6.5, and then the stirring is stopped, and the emulsion is discharged.

[0065] The preparation methods of the emulsions provided in the remaining application examples, comparative application examples and blank application examples are consistent with those of application example 1, and no related components are added.

[0066] Effect Example 1 Sebum gland cell viability test

[0067] This effect example investigates the inhibitory effect of the diet metabolism regulating anti-acne composition prepared in the examples and comparative examples on IGF-1 induced sebum cell proliferation.

[0068] Experimental materials: the cell line is human sebum gland cells (SZ95, passage: P7); the culture solution is a culture medium containing 10% FBS and no sodium pyruvate DMEM; the culture conditions are 37°C, 5% CO2, and saturated humidity; and the MTT solution concentration is 5 mg / mL.

[0069] Experimental steps: the model group is pre-treated with IGF-1 (20 ng / ml) for 6 h, and then the cells are exposed to the culture solution for 72 h; the sample group is exposed to different compositions (concentration of 1.5%) for 72 h after being treated with IGF-1 for 6 h; and the blank control group is the cells cultured for 72 h without IGF-1 and compositions. After the culture is completed, 20 μL of MTT solution is added to each well, and the cells are cultured for 3-4 h. The liquid in the well is removed, 100 μL of DMSO is added to each well, and the cells are placed on a shaker for 10 min. The absorbance is measured at 570 nm on an enzyme label instrument.

[0070] Inhibition rate (%) = (model group cell viability - sample group cell viability) / model group cell viability x 100%.

[0071] The test results are shown in Table 4.

[0072] Table 4

[0073]

[0074]

[0075] Note: compared with the model group, significance is indicated by *, P value < 0.05 is indicated by *, P value < 0.01 is indicated by **, P value < 0.001 is indicated by ***, no significance, P value > 0.05 is indicated by ns.

[0076] Promoting sebum cell apoptosis not only reduces sebum secretion, but also prevents excessive inflammatory reactions. Studies have shown that IGF-1 promotes sebum cell proliferation and differentiation, inhibits apoptosis, and thus induces excessive sebum secretion and promotes the development of acne. The diet metabolism regulating anti-acne composition prepared in the present application has a strong inhibitory effect on IGF-1.

[0077] As can be seen from the comparison of Examples 1-9, the weight parts of the components affect the comprehensive effect of the diet metabolism regulating and acne-removing composition, and when the weight parts of the components are further selected within the preferred range, the diet metabolism regulating and acne-removing composition obtained has a stronger inhibitory effect on the IGF-1 induced proliferation of sebaceous gland cells.

[0078] As can be seen from the comparison of Examples 1 and Comparative Examples 1-9, the radix rehmanniae extract, radix peucedani extract, 10-hydroxy decanoic acid, anthocyanin, and guaiacum extract in the diet metabolism regulating and acne-removing composition of the present application can synergize with each other and are indispensable.

[0079] Effect Example 2 Anti-inflammatory test

[0080] This effect example explores the anti-inflammatory effect of the diet metabolism regulating and acne-removing composition prepared from the examples and comparative examples.

[0081] 1. Experimental materials: cell line: mouse macrophage (RAW264.7), source: cell resource center of institute of basic medical sciences, Chinese academy of medical sciences, fetal bovine serum (FBS, Gibco), DMEM high-sugar medium (DMEM, Gibco), dimethyl sulfoxide (DMSO, Sigma), phosphate buffer (PBS, Gibco), mouse interleukin-1β enzyme-linked immunosorbent assay kit (Mouse IL-1β ELISA kit, Boster)

[0082] 2. Experimental groups: as shown in Table 5;

[0083] 3. Test steps: the cells were cultured conventionally, the cell suspension was inoculated in a 12-well plate, and was incubated in a 37℃, 5% CO2 incubator for 18-24h. The culture plate was taken out, and the original culture solution in the hole was discarded. 1mL of culture solution containing 1.5% of the test sample and peptidoglycan (LPS) was added to each hole of the sample group. The culture solution containing LPS as a stimulant was added to the model group, 1mL of culture solution containing dexamethasone and LPS was added to the positive control group, and only the culture solution was added to the blank control group, and was cultured for 24h. The supernatant was collected and stored at-80℃, and the inflammatory factor IL-1β was determined by using the ELISA kit. The data was analyzed by using SPSS, and the mean ± standard deviation was used, and if P<0.05, the difference was considered to have statistical significance. The IL-1β inhibition rate (%)=(model control group IL-1β content-sample group IL-1β content) / model control group IL-1β content.

[0084] The experimental results are shown in Table 6.

[0085] Table 5

[0086] Group Culture condition Induction condition Blank control group (NT) Culture medium / Model control group (M) Culture medium LPS Test sample group (TA) 1.5% sample culture medium LPS Positive control group (PC) Culture medium containing dexamethasone LPS

[0087] Table 6

[0088] Group Inhibition rate (%) Positive control group (PC) 85.55*** Example 1 27.85** Example 2 27.56** Example 3 15.38* Example 4 15.80* Example 5 20.17* Example 6 21.86* Example 7 27.26** Example 8 14.31* Example 9 13.69* Comparative Example 1 5.15 ns ]]> Comparative Example 2 5.01 ns ]] Comparative Example 3 3.09 ns ]] Comparative Example 4 3.14 ns ]]> Comparative Example 5 3.45 ns ]]> Comparative Example 6 3.61 ns ]]> Comparative Example 7 4.89 ns ]] Comparative Example 8 3.92 ns ]]> Comparative Example 9 3.80 ns ]]>

[0089] Note: Compared with the model group, significance is represented by * for P value < 0.05, ** for P value < 0.01, *** for P value < 0.001, and no significance for P value > 0.05.

[0090] Interleukin-1β (IL-1β) plays an important role in immune regulation and inflammation, and is considered as one of the main endogenous mediators causing fever reaction in the process of inflammation. The acne-removing composition for regulating dietary metabolism prepared by the present application has good anti-inflammatory effect.

[0091] It can be known from the comparison of Examples 1-9 that the weight parts of the components affect the comprehensive effect of the acne-removing composition for regulating dietary metabolism, and the anti-inflammatory effect of the acne-removing composition for regulating dietary metabolism is stronger when the weight parts of the components are further selected within the preferred range.

[0092] It can be known from the comparison of Example 1 and Comparative Examples 1-9 that the rehmannia extract, radix peucedani extract, 10-hydroxy decanoic acid, anthocyanin and guaiacum extract in the acne-removing composition for regulating dietary metabolism of the present application can synergize with each other and are indispensable.

[0093] Effect Example 3 Application Test

[0094] The effect example tests the improvement effects of the application example, the comparative application example and the blank application example on acne, oil content, skin barrier and pore size of sensitive skin population.

[0095] The specific test method is as follows: according to the Test of “Cosmetic Safety Technology Standard” (2015), 18-45 year-old sensitive skin volunteers (lactic acid stinging score > 3) are selected and randomly divided into 20 groups, 5 people in each group, and the volunteers have at least 4-10 obvious acne. Under normal circumstances, the volunteers continuously use the product on the whole face for 14 days; the volunteers take an appropriate amount of lotion after cleansing and moisturizing in the morning and evening, apply it to the face, massage and absorb it, and the acne area can be overlaid. The product is used on the whole face once in the morning and once in the evening, and the improvement rate data of the invention is presented for 14 days on the 0th, 3rd, 7th and 14th days. The volunteers visit the test area on the day of the visit without applying any product after washing their faces with water, and sit quietly in an air-conditioned room with a temperature of 21±1℃ and a humidity of 50±10% for 20 minutes. The improvement of facial acne indicators is quantified and photographed by instruments, including acne count (classification count: comedones, papules, VISIA and doctor evaluation are used respectively), Sebumeter SM 815 test oil content, Primos CR (5.8E) test pore size, and Tewameter TM Hex determination of skin barrier. The improvement rate on the 14th day = (average value of the 0th day test - average value of the 14th day test) / average value of the 0th day test x 100%;

[0096] The results are shown in Table 7.

[0097] Table 7

[0098]

[0099]

[0100]

[0101] Note: Compared with the blank control group, significance is represented by * for P value < 0.05, ** for P value < 0.01, *** for P value < 0.001, no significance for P value > 0.05, and ns.

[0102] Figure 1 Figures are human facial acne improvement effect graphs before and after using the product of application example 1 and comparative application example 1; wherein figure (a) is a human facial acne improvement effect graph before and after using the product of application example 1, and figure (b) is a human facial acne improvement effect graph before and after using the product of comparative application example 1.

[0103] Figure 2 Figures are human facial pore improvement effect graphs before and after using the product of application example 1 and comparative application example 1; wherein figure (c) is a human facial pore improvement effect graph before and after using the product of application example 1, and figure (d) is a human facial pore improvement effect graph before and after using the product of comparative application example 1.

[0104] ByFigures 1-2 It can be seen that the emulsion prepared in application example 1 of the present application has good improvement in acne and pores on the human face after 14 days of use. As can be seen from the above table, the emulsion prepared in the application example can regulate water and oil balance, unblock pores, repair skin barrier and improve and prevent acne.

[0105] Although the skin acne has certain natural recovery effect, due to the continuous existence of inflammation in the bottom layer of the skin, it still faces the risk of increasing, aggravating or slowly healing acne. As can be seen from effect examples 1-2, the acne-removing composition for regulating dietary metabolism can play a significant oil control and anti-inflammatory effect from the mechanism, and has the potential to prevent acne and accelerate the improvement of acne. Therefore, further from the effect examples, it can be seen from application examples 1-9 that compared with the blank application example, the acne-removing composition for regulating dietary metabolism accelerates the healing of acne, significantly reduces the number of comedones and papules, and plays an actual prevention and improvement effect. However, the weight parts of the components will affect the comprehensive effect of the emulsion, and when the weight parts of the components in the further selected acne-removing composition for regulating dietary metabolism are within the preferred range, the comprehensive effect of the obtained emulsion is better.

[0106] As can be seen from application example 1 and comparative application examples 1-9, whether any one of the acne-removing composition for regulating dietary metabolism is missing, or other components with similar effects are used to replace the corresponding components in the acne-removing composition for regulating dietary metabolism, the obtained emulsion cannot achieve the effect of the present application.

[0107] Finally, it should be noted that the above examples are only used to illustrate the technical solutions of the present application and not to limit the protection scope of the present application. Although the present application has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present application can be modified or replaced by equivalents without departing from the essence and scope of the technical solutions of the present application.

Claims

1. An acne-removing composition for regulating dietary metabolism, characterized in that, The composition comprises component A and component B, wherein the weight ratio of component A to component B is: component A: component B = (0.2-0.4):(1-1.5); Component A comprises the following components in parts by weight: 0.1-0.5 parts of Rehmannia glutinosa extract and 0.01-0.2 parts of Peucedanum praeruptorum extract; the preparation method of Rehmannia glutinosa extract is as follows: take Rehmannia glutinosa, dry and crush it, sieve it to obtain Rehmannia glutinosa coarse powder, then add 50-60% ethanol solution by volume for ultrasonic extraction, filter it, concentrate and dry the extract to obtain Rehmannia glutinosa extract. Component B comprises the following ingredients in parts by weight: 0.005-0.3 parts of 10-hydroxydecanoic acid, 0.0005-0.008 parts of anthocyanins, and 0.5-3 parts of guaiac extract.

2. The acne-removing composition for regulating dietary metabolism as described in claim 1, characterized in that, Component A comprises the following ingredients in parts by weight: 0.15-0.25 parts of Rehmannia glutinosa extract and 0.05-0.15 parts of Peucedanum praeruptorum extract; Component B comprises the following components in parts by weight: 0.04-0.1 parts of 10-hydroxydecanoic acid, 0.001-0.005 parts of anthocyanins, and 0.8-1.5 parts of guaiac extract.

3. The acne-removing composition for regulating dietary metabolism as described in claim 1, characterized in that, In component A, the weight percentage of Rehmannia glutinosa extract is 60-70%.

4. The acne-removing composition for regulating dietary metabolism as described in claim 1, characterized in that, In component B, the weight percentage of 10-hydroxydecanoic acid is 4.5-7.5%.

5. The acne-removing composition for regulating dietary metabolism as described in claim 1, characterized in that, The weight ratio of the ethanol solution to the crude Rehmannia glutinosa powder is 8-12:1; and / or the ultrasonic extraction temperature is 30-60℃, the ultrasonic extraction time is 20-60 min, and the extraction is performed 1-3 times.

6. The use of the acne-reducing composition for regulating dietary metabolism as described in any one of claims 1-5 in the preparation of skin care products.

7. A skin care product, characterized in that, The skin products include the acne-reducing composition for regulating dietary metabolism as described in any one of claims 1-5.

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