An anti-cracking repair composition containing artemisia annua and camellia seed oil, its preparation and application

Abstract

The present invention specifically relates to an anti-cracking and repairing composition containing artemisia annua and camellia seed oil, and its preparation and application, belonging to the technical field of cosmetics. The composition of the present invention is prepared by using allantoin, phenoxyethanol, ethylhexylglycerin, artemisia annua extract, urea, tocopherol, camellia seed oil, PEG / PPG-14 / 7 dimethyl ether, cholesteryl polyether-10, portulaca oleracea extract, taraxacum extract, grape seed oil, squalane, caprylic / capric triglyceride, bis(lauroyl glutamine) lysine sodium, glycerin, butanediol, carrageenan, sodium carboxymethyl cellulose and water. The cooperation among the raw materials enables the composition to have excellent anti-chapping, skin repairing and nursing, and anti-inflammatory and soothing effects, and at the same time has good stability and safety effects.

Description

Technical Field

[0001] The present invention specifically relates to an anti-cracking and repair composition containing artemisia annua and camellia seed oil, and its preparation and application, belonging to the technical field of cosmetics. Background Art

[0002] Skin chapping refers to the symptom that small cracks appear on the skin due to skin dryness. The chapped parts of the skin mostly occur in the most easily exposed parts of the human body, such as the lips, ears, fingers, back of the hands, etc. This symptom can occur not only in the cold winter but also in very hot weather. When the crack is deeper, blood will ooze out and there will be a feeling of pain.

[0003] Artemisia annua is a herbaceous plant of the genus Artemisia in the Compositae family, also known as sweet wormwood, herb wormwood, stinking wormwood, and Artemisia argyi. Artemisia annua is rich in artemisinin, artemisinic acid, methyl artemisinicate, artemisinol, etc., and also contains components such as volatile oil, flavonoids, and coumarins. The extract of Artemisia annua can moisturize and soothe, and help repair the damaged skin barrier. The volatile oil of Artemisia annua has inhibitory effects on a variety of pathogenic bacteria and can be used for the development of acne products. Artemisinin in Artemisia annua has inhibitory effects on a variety of bacteria and can be used for the development of antibacterial and anti-inflammatory products. In addition, it also has a whitening effect, which can inhibit melanin production and fade skin spots.

[0004] Camellia seed oil is rich in components such as unsaturated fatty acids and vitamin E. These substances help improve the skin barrier function and reduce water loss, thus achieving a moisturizing effect. Camellia seed oil also contains components such as squalene and palmitic acid, which can soften the cutin layer, promote its metabolism, and make the skin soft and smooth. In addition, the polyphenolic compounds in camellia seed oil have strong antioxidant ability, can scavenge free radicals, and slow down the process of cell aging. Camellia seed oil also contains components such as linolenic acid and linoleic acid with good permeability, which can penetrate deep into the skin to play a role, and at the same time has a certain antibacterial effect, which is beneficial to relieve skin discomfort caused by bacterial infection.

[0005] Currently, there are a wide variety of anti-cracking and repair cosmetic products, but their effects vary. While providing anti-cracking effects, more functions need to be provided. Therefore, it is particularly important to provide a multi-functional composition for anti-cracking and repairing the skin. Summary of the Invention

[0006] In view of the above technical problems, the inventor proposed the solution of the present invention. The solution of the present invention is specifically an anti-cracking and repair composition containing artemisia annua and camellia seed oil, and its preparation and application.

[0007] On the one hand, the present invention provides an anti-cracking and repair composition containing artemisia annua and camellia seed oil. According to mass percentage, the raw material composition is as follows:

[0008] 0.05 - 1% allantoin, 0.005 - 0.4% phenoxyethanol, 0.005 - 0.5% ethylhexylglycerin, 0.005 - 2% Artemisia annua extract, 15 - 25% urea, 0.1 - 2% tocopherol, 0.1 - 1% camellia seed oil, 1 - 4% PEG / PPG - 14 / 7 dimethyl ether, 1 - 3% cholesteryl polyether - 10, 0.1 - 2% Portulaca oleracea extract, 0.1 - 2% Taraxacum mongolicum extract, 2 - 5% grape seed oil, 1 - 3% squalane, 1 - 3% caprylic / capric triglyceride, 1 - 2.5% bis(lauroyl glutamine) lysine sodium, 1 - 5% glycerol, 1 - 4% butanediol, 0.5 - 2% carrageenan, 0.5 - 1.5% sodium carboxymethyl cellulose and the balance water.

[0009] Preferably, by mass percentage, the dosage of Artemisia annua extract is 0.008 - 1.5%. The Artemisia annua extract used in the present invention can be obtained by conventional processes. It is not limited to the following process: Artemisia annua extract: The dried Artemisia annua leaves (i.e., the leaves of Artemisia annua L.) are crushed, added with 30 - 65wt% ethanol aqueous solution, heated and stirred, filtered, and dried to obtain the Artemisia annua extract (i.e., the Artemisia annua L. extract).

[0010] Preferably, by mass percentage, the dosage of camellia seed oil is 0.15 - 0.5%.

[0011] Preferably, the mass ratio of PEG / PPG - 14 / 7 dimethyl ether to cholesteryl polyether - 10 is 1.2 - 2:1.

[0012] Preferably, the preparation method of Portulaca oleracea extract includes the following steps:

[0013] Step 1: The dried whole plant of Portulaca oleracea is crushed to obtain a crushed product, added with 10 - 30 times the mass of water of the crushed product, stirred at 50 - 60°C for 2 - 6 hours to obtain Product 1;

[0014] Step 2: Product 1 is cooled, ethanol is added, the ethanol mass concentration is adjusted to 65 - 85%, stirred at 45 - 55°C for 3 - 7 hours, and then cooled to obtain Product 2;

[0015] Step 3: Product 2 is filtered to obtain a filtrate, and then dried to obtain the Portulaca oleracea extract.

[0016] Preferably, the preparation method of Taraxacum mongolicum extract includes the following steps:

[0017] S1: The dried whole herb of Taraxacum mongolicum is crushed to obtain a crushed product, added with 10 - 30 times the mass of 55 - 65wt% ethanol aqueous solution of the crushed product, stirred at 40 - 55°C for 3 - 6 hours, filtered, and cooled to obtain Product 1;

[0018] S2: The product 1 is concentrated under reduced pressure to 5 - 20 wt% of its mass to obtain a concentrate. Then, an extractant composed of an oil phase and an aqueous phase in a mass ratio of 1:0.2 - 0.4 and 15 - 40 times the mass of the concentrate is added. Stir and extract at 40 - 50 °C for 2 - 5 hours, then let it stand for layering, and take the oil phase obtained from the standing layering as product 3. Among them, the oil phase is composed of ethyl acetate and cyclohexane in a mass ratio of 1:2 - 3.5, and the aqueous phase is water.

[0019] S3: Concentrate product 3 under reduced pressure until ethyl acetate and cyclohexane are undetectable, then stop the reduced - pressure concentration to obtain dandelion extract.

[0020] Preferably, the mass ratio of purslane extract to dandelion extract is 1:0.8 - 1.5.

[0021] Preferably, the dosage of urea is 18 - 23% by mass percentage.

[0022] On the other hand, the present invention provides a preparation method of the above - mentioned anti - cracking and repair composition containing artemisia annua and camellia seed oil, including the steps of mixing the raw materials and sterilizing.

[0023] The present invention also provides the application of the above - mentioned anti - cracking and repair composition containing artemisia annua and camellia seed oil in the preparation of a preparation for preventing or treating skin chapping, and the mass percentage of the anti - cracking and repair composition containing artemisia annua and camellia seed oil in the preparation is 1 - 20%.

[0024] The beneficial effects of the present invention include but are not limited to:

[0025] The present invention uses allantoin, phenoxyethanol, ethylhexylglycerin, artemisia annua extract, urea, tocopherol, camellia seed oil, PEG / PPG - 14 / 7 dimethyl ether, cholesteryl polyether - 10, purslane extract, dandelion extract, grape seed oil, squalane, caprylic / capric triglyceride, bis (laurylamidoglutamine) lysine sodium, glycerin, butanediol, carrageenan, sodium carboxymethylcellulose and water to jointly prepare an anti - cracking and repair composition. The cooperation among the raw materials makes the composition have excellent effects.

[0026] The composition prepared by the present invention has extremely low irritation and high safety; and also has excellent room - temperature stability; after being placed at high temperature, its Zeta potential changes little and still has good stability.

[0027] The present invention uses PEG / PPG-14 / 7 dimethyl ether and cholesteryl polyether-10 in combination, which can mutually promote the improvement of the stability of the composition. The two act as emulsifiers to produce a compounding effect, making the emulsifying effect of the composition better and the raw materials in the composition more uniformly dispersed. In the composition system of the present invention, using PEG / PPG-14 / 7 dimethyl ether and cholesteryl polyether-10 with a mass ratio of 1.2-2:1 can make the composition have better stability.

[0028] The composition prepared by the present invention can effectively inhibit the expression of inflammatory factors, has excellent anti-inflammatory effects, and makes the skin feel more comfortable.

[0029] The composition prepared by combining Portulaca oleracea extract and Taraxacum mongolicum extract prepared by a specific process of the present invention has better anti-inflammatory effects than the composition using only one of the extracts. The combination of the two can enrich the types of anti-inflammatory factor active substances in the composition, making the advantages complementary and synergistically enhancing the anti-inflammatory effect of the composition.

[0030] When preparing the Portulaca oleracea extract in the present invention, when the ethanol concentration is adjusted to 65-85 wt%, the extract has better anti-inflammatory effects and can endow the composition with higher anti-inflammatory performance.

[0031] The present invention uses ethyl acetate and cyclohexane in combination as the oil phase to obtain an extractant for extracting Taraxacum mongolicum extract. Compared with using only one of them as the oil phase or using other oil phases, the obtained Taraxacum mongolicum extract has better anti-inflammatory effects and can make the composition better anti-inflammatory and soothe the skin. And the composition using ethyl acetate and cyclohexane with a mass ratio of 1:2-3.5 as the extractant has better anti-inflammatory effects than the compositions with other ratios.

[0032] The composition prepared by the present invention can efficiently promote the healing of chapped skin and effectively prevent skin chapping.

[0033] The product of the present invention has excellent performance, and the preparation process is simple, having good application prospects. Detailed Description of the Invention

[0034] The present invention will be described in detail below with reference to the embodiments, but the present invention is not limited to these embodiments. Unless otherwise specified, the raw materials in the embodiments of the present invention are all purchased through commercial channels.

[0035] Artemisia annua extract: The dried Artemisia annua leaves (i.e., Artemisia annua L.) are crushed, added with a 45 wt% ethanol aqueous solution 15 times the mass of Artemisia annua, stirred at 65 °C and 65 rpm for 4.2 hours, filtered, and freeze-dried at -42 °C until the water content is 2.45 wt% to obtain the Artemisia annua extract.

[0036] Tocopherol: Zhengzhou Kangyuan Chemical Products Co., Ltd. Camellia seed oil: Baoji Fangsheng Biological Development Co., Ltd. Grape seed oil: Hubei Xinjiecheng Chemical Technology Co., Ltd. Carrageenan: Shandong Xinxiong Biotechnology Co., Ltd. Sodium carboxymethylcellulose: Hubei Mingtuo Biotechnology Co., Ltd.

[0037] I. Preparation of the composition

[0038] 1. Composition 1

[0039] Raw material composition, mass percentage: 0.2% allantoin, 0.1% phenoxyethanol, 0.1% ethylhexylglycerin, 0.7% artemisia annua extract, 20% urea, 0.2% tocopherol, 0.2% camellia seed oil, 3.6% PEG / PPG-14 / 7 dimethyl ether, 2.4% cholesteryl polyether-10, 1.5% portulaca oleracea extract, 1.8% taraxacum mongolicum extract, 4% grape seed oil, 2% squalane, 2% caprylic / capric triglyceride, 1.8% bis(lauroyl glutamine) lysine sodium, 4% glycerol, 3% 1,3-butanediol, 1.5% carrageenan, 1% sodium carboxymethylcellulose and the balance water.

[0040] The mass ratio of PEG / PPG-14 / 7 dimethyl ether to cholesteryl polyether-10 is 1.5:1; the mass ratio of portulaca oleracea extract to taraxacum mongolicum extract is 1:1.2.

[0041] Preparation method of portulaca oleracea extract, which comprises the following steps:

[0042] Step 1: Crush the whole dried portulaca oleracea plant to obtain a crushed product, add 20 times the mass of water of the crushed product, stir at 55 °C and 80 rpm for 4 hours to obtain product one;

[0043] Step 2: Cool product one to room temperature, add ethanol, adjust the mass concentration of ethanol to 75%, stir at 50 °C and 70 rpm for 5 hours, cool to room temperature to obtain product two;

[0044] Step 3: Filter product two through a 0.22 μm pore size filter membrane to obtain a filtrate, and then freeze-dry at -40 °C until the water content is 1.92 wt% to obtain the portulaca oleracea extract.

[0045] The preparation method of taraxacum mongolicum extract comprises the following steps:

[0046] S1: Crush the whole dried taraxacum mongolicum herb to obtain a crushed product, add 22 times the mass of 60 wt% ethanol aqueous solution of the crushed product, stir at 50 °C and 75 rpm for 5 hours, filter through a 1 μm pore size filter membrane, cool the filtrate to room temperature to obtain product 1;

[0047] S2: The product 1 is concentrated under reduced pressure at 55 °C and 0.0075 MPa to 11.5 wt% of the mass of the product 1 to obtain a concentrate. An extractant composed of an oil phase and an aqueous phase in a mass ratio of 1:0.3 and 32 times the mass of the concentrate is added, and the mixture is stirred and extracted at 45 °C and 60 rpm for 4 hours, then left to stand for 2 hours for stratification, and the obtained oil phase is taken as product 3; wherein, the oil phase is composed of ethyl acetate and cyclohexane in a mass ratio of 1:3, and the aqueous phase is water;

[0048] S3: The product 3 is concentrated under reduced pressure at 50 °C and 0.007 MPa until ethyl acetate and cyclohexane are undetectable, and the reduced-pressure concentration is stopped to obtain dandelion extract.

[0049] The preparation method of the composition is as follows:

[0050] Water is added to 60 °C, and sodium lauroyl glutamyl lysine, PEG / PPG-14 / 7 dimethyl ether, cholesteryl polyether-10, urea, carrageenan, and sodium carboxymethylcellulose are added, and the mixture is stirred at 75 rpm for 1 hour to obtain intermediate material 1;

[0051] Camellia seed oil, ethylhexylglycerin, grape seed oil, squalane, caprylic / capric triglyceride, glycerol, and 1,3-butanediol are mixed, heated at 80 °C and stirred at 90 rpm for 0.5 hour to obtain intermediate material 2;

[0052] The intermediate material 2 is added to the intermediate material 1, stirred at 150 rpm for 0.5 hour, cooled and kept at 35 °C, allantoin, phenoxyethanol, artemisia extract, tocopherol, portulaca extract, and dandelion extract are added, stirred at 150 rpm for 0.3 hour, and sterilized to obtain the composition.

[0053] 2. Composition 2

[0054] Raw material composition, mass percentage: 0.25% allantoin, 0.15% phenoxyethanol, 0.08% ethylhexylglycerin, 0.75% artemisia extract, 22% urea, 0.15% tocopherol, 0.15% camellia seed oil, 4% PEG / PPG-14 / 7 dimethyl ether, 2% cholesteryl polyether-10, 1.8% portulaca extract, 1.5% dandelion extract, 3.5% grape seed oil, 2.2% squalane, 2.1% caprylic / capric triglyceride, 1.75% sodium lauroyl glutamyl lysine, 3.8% glycerol, 3.2% 1,3-butanediol, 1.4% carrageenan, 1.1% sodium carboxymethylcellulose, and the balance water.

[0055] The mass ratio of PEG / PPG-14 / 7 dimethyl ether to cholesteryl polyether-10 is 2:1; the mass ratio of portulaca extract to dandelion extract is 1:0.83.

[0056] Preparation method of purslane extract, comprising the following steps:

[0057] Step 1: Crush the whole dried purslane plant to obtain a crushed material, add 22 times the mass of water of the crushed material, stir at 57 °C and 80 rpm for 4.5 hours to obtain Product 1;

[0058] Step 2: Cool Product 1 to room temperature, add ethanol, adjust the mass concentration of ethanol to 65%, stir at 50 °C and 70 rpm for 5.5 hours, and cool to room temperature to obtain Product 2;

[0059] Step 3: Filter Product 2 through a 0.22-micron pore size filter membrane to obtain a filtrate, and then freeze-dry at -40 °C until the water content is 1.95 wt% to obtain the purslane extract.

[0060] The preparation method of dandelion extract comprises the following steps:

[0061] S1: Crush the whole dried dandelion herb to obtain a crushed material, add 27 times the mass of 55 wt% ethanol aqueous solution of the crushed material, stir at 50 °C and 75 rpm for 5.5 hours, filter through a 1-micron pore size filter membrane to obtain a filtrate, and cool the filtrate to room temperature to obtain Product 1;

[0062] S2: Concentrate Product 1 under reduced pressure at 55 °C and 0.0075 MPa to 12.6 wt% of the mass of Product 1 to obtain a concentrate, add 38 times the mass of the concentrate of an extractant composed of an oil phase and a water phase in a mass ratio of 1:0.0.2, stir and extract at 45 °C and 60 rpm for 4.5 hours, then let stand for 2.5 hours for layering, and take the oil phase obtained by standing layering as Product 3; wherein, the oil phase is composed of ethyl acetate and cyclohexane in a mass ratio of 1:2, and the water phase is water;

[0063] S3: Concentrate Product 3 under reduced pressure at 50 °C and 0.007 MPa until ethyl acetate and cyclohexane are not detected, stop the reduced pressure concentration to obtain the dandelion extract.

[0064] The preparation method of the composition is as follows:

[0065] Add water to 58 °C, add sodium lauroyl glutamyl lysinate, PEG / PPG-14 / 7 dimethyl ether, cholesteryl polyether-10, urea, carrageenan, sodium carboxymethylcellulose, and stir at 70 rpm for 1.5 hours to obtain Intermediate 1;

[0066] Mix camellia seed oil, ethylhexylglycerin, grape seed oil, squalane, caprylic / capric triglyceride, glycerol, 1,3-butanediol, heat at 78 °C and stir at 90 rpm for 0.4 hours to obtain Intermediate 2;

[0067] Add the intermediate material 2 to the intermediate material 1, stir at 150 rpm for 0.6 hours, cool and keep warm at 37°C, add allantoin, phenoxyethanol, artemisia annua extract, tocopherol, portulaca oleracea extract, and taraxacum extract, stir at 150 rpm for 0.4 hours, and sterilize to obtain the composition.

[0068] 3. Composition 3

[0069] The difference from Composition 1 lies in the raw material composition, by mass percentage: 0.2% allantoin, 0.1% phenoxyethanol, 0.1% ethylhexylglycerin, 0.7% artemisia annua extract, 20% urea, 0.2% tocopherol, 0.2% camellia seed oil, 6% PEG / PPG-14 / 7 dimethyl ether, 1.5% portulaca oleracea extract, 1.8% taraxacum extract, 4% grape seed oil, 2% squalane, 2% caprylic / capric triglyceride, 1.8% bis(lauroyl glutamine) lysine sodium, 4% glycerin, 3% 1,3-butanediol, 1.5% carrageenan, 1% sodium carboxymethylcellulose, and the balance of water. Others are the same as Composition 1.

[0070] 4. Composition 4

[0071] The difference from Composition 1 lies in the raw material composition, by mass percentage: 0.2% allantoin, 0.1% phenoxyethanol, 0.1% ethylhexylglycerin, 0.7% artemisia annua extract, 20% urea, 0.2% tocopherol, 0.2% camellia seed oil, 6% cholesteryl polyether-10, 1.5% portulaca oleracea extract, 1.8% taraxacum extract, 4% grape seed oil, 2% squalane, 2% caprylic / capric triglyceride, 1.8% bis(lauroyl glutamine) lysine sodium, 4% glycerin, 3% 1,3-butanediol, 1.5% carrageenan, 1% sodium carboxymethylcellulose, and the balance of water. Others are the same as Composition 1.

[0072] 5. Composition 5

[0073] The difference from Composition 1 lies in the raw material composition, by mass percentage: 0.2% allantoin, 0.1% phenoxyethanol, 0.1% ethylhexylglycerin, 0.7% artemisia annua extract, 20% urea, 0.2% tocopherol, 0.2% camellia seed oil, 2% PEG / PPG-14 / 7 dimethyl ether, 4% cholesteryl polyether-10, 1.5% portulaca oleracea extract, 1.8% taraxacum extract, 4% grape seed oil, 2% squalane, 2% caprylic / capric triglyceride, 1.8% bis(lauroyl glutamine) lysine sodium, 4% glycerin, 3% 1,3-butanediol, 1.5% carrageenan, 1% sodium carboxymethylcellulose, and the balance of water. The mass ratio of PEG / PPG-14 / 7 dimethyl ether to cholesteryl polyether-10 is 0.5:1. Others are the same as Composition 1.

[0074] 6. Composition 6

[0075] The differences from Composition 1 are as follows: raw material composition, mass percentages: 0.2% allantoin, 0.1% phenoxyethanol, 0.1% ethylhexylglycerin, 0.7% artemisia annua extract, 20% urea, 0.2% tocopherol, 0.2% camellia seed oil, 5% PEG / PPG-14 / 7 dimethyl ether, 1% cholesteryl polyether-10, 1.5% portulaca oleracea extract, 1.8% taraxacum mongolicum extract, 4% grape seed oil, 2% squalane, 2% caprylic / capric triglyceride, 1.8% bis(lauroyl glutamine) lysine sodium, 4% glycerol, 3% 1,3-butanediol, 1.5% carrageenan, 1% sodium carboxymethylcellulose, and the balance water. The mass ratio of PEG / PPG-14 / 7 dimethyl ether to cholesteryl polyether-10 is 5:1. Others are the same as Composition 1.

[0076] 7. Composition 7

[0077] The differences from Composition 1 are as follows: raw material composition, mass percentages: 0.2% allantoin, 0.1% phenoxyethanol, 0.1% ethylhexylglycerin, 0.7% artemisia annua extract, 20% urea, 0.2% tocopherol, 0.2% camellia seed oil, 3.6% PEG / PPG-14 / 7 dimethyl ether, 2.4% cholesteryl polyether-10, 3.3% taraxacum mongolicum extract, 4% grape seed oil, 2% squalane, 2% caprylic / capric triglyceride, 1.8% bis(lauroyl glutamine) lysine sodium, 4% glycerol, 3% 1,3-butanediol, 1.5% carrageenan, 1% sodium carboxymethylcellulose, and the balance water. Others are the same as Composition 1.

[0078] 8. Composition 8

[0079] The differences from Composition 1 are as follows: raw material composition, mass percentages: 0.2% allantoin, 0.1% phenoxyethanol, 0.1% ethylhexylglycerin, 0.7% artemisia annua extract, 20% urea, 0.2% tocopherol, 0.2% camellia seed oil, 3.6% PEG / PPG-14 / 7 dimethyl ether, 2.4% cholesteryl polyether-10, 3.3% portulaca oleracea extract, 4% grape seed oil, 2% squalane, 2% caprylic / capric triglyceride, 1.8% bis(lauroyl glutamine) lysine sodium, 4% glycerol, 3% 1,3-butanediol, 1.5% carrageenan, 1% sodium carboxymethylcellulose, and the balance water. Others are the same as Composition 1.

[0080] 9. Composition 9

[0081] The differences from Composition 1 are as follows: in the extraction method of portulaca oleracea, step 2: after the first product is cooled, ethanol is added, and the mass concentration of ethanol is adjusted to 40%, and it is stirred at 45 - 55 °C for 3 - 7 hours and then cooled to obtain the second product. Others are the same as Composition 1.

[0082] 10. Composition 10

[0083] It is different from Composition 1 in that in the dandelion extraction method, the oil phase in S2 uses chloroform to replace ethyl acetate and cyclohexane. Others are the same as Composition 1.

[0084] 11. Composition 11

[0085] It is different from Composition 1 in that in the dandelion extraction method, the oil phase in S2 only uses ethyl acetate. Others are the same as Composition 1.

[0086] 12. Composition 12

[0087] It is different from Composition 1 in that in the dandelion extraction method, the oil phase in S2 only uses cyclohexane. Others are the same as Composition 1.

[0088] 13. Composition 13

[0089] It is different from Composition 1 in that in the dandelion extraction method, the oil phase in S2 is composed of ethyl acetate and cyclohexane in a mass ratio of 1:0.5. Others are the same as Composition 1.

[0090] 14. Composition 14

[0091] It is different from Composition 1 in that it does not contain purslane extract and dandelion extract, and others are the same as Composition 1.

[0092] II. Tests

[0093] 1. Safety test

[0094] Mix the above composition and deionized water according to a mass ratio of 5:95, stir at 50 °C and 300 rpm for 0.5 hours, and cool to room temperature to obtain a solution as the sample for the safety test.

[0095] Select 140 healthy volunteers aged 30 - 45 years old, randomly divide them into 14 groups, with 10 people in each group. Select a patch tester with an area of about 40 mm 2 and a depth of about 1 mm, add the above sample, and then apply it to the inner forearm of the left arm of the volunteer. Gently press it to make it evenly adhere to the skin for 24 hours; observe the skin appearance 30 minutes after removing the patch tester, and evaluate the safety of each group of samples on the skin according to the evaluation criteria recorded in Table 1. The observation results are shown in Table 2.

[0096] Table 1: Evaluation criteria

[0097] Degree of reaction Grade Apparent skin condition - 0 Negative reaction ± 1 Suspicious reaction, only slight erythema + 2 Weak positive reaction (erythema reaction); erythema, infiltration, edema, may have papules ++ 3 Strong positive reaction (vesicle reaction); erythema, infiltration, edema, papules, vesicles; the reaction may extend beyond the test area +++ 4 Obvious erythema, severe infiltration, edema, confluent vesicles; the reaction extends beyond the test

[0098] Table 2: Safety test results

[0099] Serial number / number of people Grade 0 Grade 1 Grade 2 Grade 3 Grade 4 Composition 1 10 0 0 0 0 Composition 2 10 0 0 0 0 Composition 3 10 0 0 0 0 Composition 4 10 0 0 0 0 Composition 5 10 0 0 0 0 Composition 6 10 0 0 0 0 Composition 7 10 0 0 0 0 Composition 8 10 0 0 0 0 Composition 9 10 0 0 0 0 Composition 10 10 0 0 0 0 Composition 11 10 0 0 0 0 Composition 12 10 0 0 0 0 Composition 13 10 0 0 0 0 Composition 14 10 0 0 0 0

[0100] According to the test results in Table 2, the composition prepared by the present invention has extremely low irritation and high safety.

[0101] 2. Stability test

[0102] Zeta potential is an important indicator to measure the stability of a dispersion system. The larger the absolute value of the Zeta potential, the higher the stability of the system. The effects of Compositions 1-6 were tested to verify the influence of PEG / PPG-14 / 7 dimethyl ether and cholesteryl polyether-10 on the stability of the composition.

[0103] The specific test method is as follows: Dilute the above Compositions 1-6 with deionized water to a mass concentration of 2.5%, stir at 300 rpm for 0.5 hours to obtain samples for stability testing, perform Zeta potential testing on the samples for conventional Zeta potential; after testing the conventional Zeta potential, seal and place in an incubator at 55°C for 24 hours, and then test the Zeta potential again to obtain the high-temperature Zeta potential. The results are shown in Table 3.

[0104] Table 3: Stability test

[0105] Serial number Conventional Zeta potential / mV High-temperature Zeta potential / mV Composition 1 -54.37 -48.28 Composition 2 -52.91 -47.06 Composition 3 -48.24 -43.17 Composition 4 -46.13 -41.36 Composition 5 -49.07 -43.85 Composition 6 -51.42 -45.79

[0106] According to the tests in Table 3, the composition prepared by the present invention has excellent room-temperature stability; and after high-temperature treatment, the change in Zeta potential is small, and it still has good stability.

[0107] According to the test comparison of Compositions 1, 3-4, in Compositions 3-4, compared with Composition 1 which only uses one of PEG / PPG-14 / 7 dimethyl ether and cholesteryl polyether-10, the absolute value of the Zeta potential of the obtained composition is for Composition 1; thus, it can be seen that the present invention uses PEG / PPG-14 / 7 dimethyl ether and cholesteryl polyether-10 in combination, which can mutually promote the improvement of the stability of the composition. It is speculated that this may be due to the compounding effect of the two as emulsifiers, making the emulsification effect of the composition better and the raw materials in the composition more evenly dispersed.

[0108] In Compositions 5-6, when the mass ratio of PEG / PPG-14 / 7 dimethyl ether and cholesteryl polyether-10 is changed, the absolute value of the Zeta potential of the obtained composition is lower than that of Composition 1. In the composition system of the present invention, using PEG / PPG-14 / 7 dimethyl ether and cholesteryl polyether-10 with a mass ratio of 1.2-2:1 can make the composition have better stability.

[0109] 3. Anti-inflammatory test

[0110] Anti - inflammation is an important functional index of cosmetics. The present invention tests the anti - inflammatory effects of Compositions 1 - 2 and 7 - 13 to verify the influence of purslane extract and dandelion extract on the anti - inflammatory effect of the compositions of the present invention, and at the same time verifies the anti - inflammatory effects of purslane extract and dandelion extract obtained by different extraction processes.

[0111] Specifically, the anti - inflammatory test specifically refers to T / SHRH033 - 2021 "Test Method for the Soothing Efficacy of Cosmetics - Determination of the Content of TNF - α Inflammatory Factor in Vitro, Lipopolysaccharide - Induced Macrophage RAW264.7 Test Method" to test the amount of TNF - α secreted by macrophage RAW264.7. Among them, the blank group does not add LPS and Compositions 1 - 12; the model group only adds LPS with an added concentration of 1 mg / mL; in the Compositions 1 - 13 group, in addition to adding LPS (added concentration of 1 mg / mL), Compositions 1 - 12 are sequentially added (the added concentration of Compositions 1 - 12 is 10 wt%). The content of TNF - α inflammatory factor in each group is statistically obtained; at the same time, the reduction amount of TNF - α inflammatory factor content in each group compared with the model group is calculated. The test results are shown in Table 4.

[0112] Table 4: Anti - inflammatory Test

[0113] Serial number TNF-α / ng / mL Reduction compared with the model group / ng / mL Blank group 0.77 16.79 Model group 17.56 0 Composition 1 9.13 8.43 Composition 2 9.58 7.98 Composition 7 10.24 7.32 Composition 8 10.83 6.73 Composition 9 10.15 7.41 Composition 10 11.52 6.04 Composition 11 10.91 6.65 Composition 12 10.37 7.19 Composition 13 9.72 7.84 Composition 14 14.09 3.47

[0114] According to the test results in Table 4, it can be seen that the compositions prepared by the present invention can effectively inhibit the expression of inflammatory factors, have excellent anti - inflammatory effects, and make the skin feel more comfortable.

[0115] According to the comparison of the test results of Compositions 1 and 7 - 8, it can be seen that the composition 1 prepared by combining purslane extract and dandelion extract prepared by a specific process of the present invention has a better anti - inflammatory effect than Compositions 7 and 8 that only use one of the extracts. The combination of the two enriches the types of anti - inflammatory factor active substances in the composition, making the advantages complementary and synergistically enhancing the anti - inflammatory effect of the composition.

[0116] According to the comparison of Compositions 1 and 9, it can be seen that the extract obtained by adjusting the ethanol concentration too low in Step 2 during the extraction of purslane extract has relatively poor anti - inflammatory effects. When the present invention prepares purslane extract, adjusting the ethanol concentration to 65 - 85 wt% results in better anti - inflammatory effects of the extract and can endow the composition with higher anti - inflammatory performance.

[0117] According to the test results of Compositions 1 and 14, it can be seen that purslane extract and dandelion extract can endow the composition with excellent anti-inflammatory effects. By comparing Compositions 1 and 10 - 13, it is known that in the present invention, ethyl acetate and cyclohexane are used in combination as the oil phase to obtain an extractant for extracting Dandelion Extract 1. Compared with using only one of them as the oil phase or using other oil phases (such as chloroform), the obtained dandelion extract has better anti-inflammatory effects and can enable the composition to better anti-inflammatorily soothe the skin. And Composition 1 using ethyl acetate and cyclohexane as the extractant in a mass ratio of 1:2 - 3.5 has better anti-inflammatory effects than Composition 13 with other ratios.

[0118] 4. Anti-chapping test

[0119] Forty volunteers with chapped and itchy hands were recruited and randomly divided into 2 groups, with 20 people in each group. They were respectively treated with Compositions 1 and 2; the volunteers in each group applied the corresponding composition to the chapped and itchy parts, once in the morning and once in the evening every day; follow-up visits were conducted on the 10th and 25th days of use to observe the apparent conditions of the hands of the volunteers in each group, and the skin conditions of the hands of the volunteers were evaluated according to three grades: cured (skin chapping disappeared), effective (chapping condition improved), and ineffective (basically no change). The statistical results of the number of people corresponding to each grade at different times are shown in Table 5.

[0120] Table 5: Anti-chapping test

[0121]

[0122] According to the test results in Table 5, it can be seen that the composition prepared in the present invention can efficiently promote the healing of chapped skin and can effectively prevent skin chapping.

[0123] The above are only examples of the present invention. The protection scope of the present invention is not limited by these specific examples, but is determined by the claims of the present invention. For those skilled in the art, the present invention can have various modifications and changes. Any modifications, equivalent replacements, improvements, etc. made within the technical idea and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. An anti-crack repair composition containing Artemisia annua and camellia oil, characterized in that: According to the mass percentage, the raw material composition is: 0.05-1% allantoin, 0.005-0.4% phenoxyethanol, 0.005-0.5% ethylhexylglycerin, 0.005-2% artemisia annua extract, 15-25% urea, 0.1-2% tocopherol, 0.1-1% camellia seed oil, 1-4% PEG / PPG-14 / 7 dimethyl ether, 1-3% cholesteryl polyether-10, 0.1-2% purslane extract, 0.1-2% dandelion extract, 2-5% grape seed oil, 1-3% squalane, 1-3% caprylic / capric triglyceride, 1-2.5% sodium di(laurylamide glutamine) lysine, 1-5% glycerol, 1-4% butylene glycol, 0.5-2% carrageenan, 0.5-1.5% sodium carboxymethyl cellulose and the balance water; the mass ratio of PEG / PPG-14 / 7 dimethyl ether and cholesterol polyether-10 is 1.2-2:1; The preparation method of purslane extract comprises the following steps: Step 1: Grind the dried whole plant of Purslane to obtain a pulverized product, add 10-30 times the mass of water of the pulverized product, stir at 50-60° C. for 2-6 hours, and obtain product 1; Step 2: Cool the product 1, add ethanol to adjust the ethanol mass concentration to 65-85%, stir at 45-55°C for 3-7 hours, and cool to obtain product 2; Step 3: filtering the second product to obtain a filtrate, and then drying to obtain the purslane extract; The preparation method of dandelion extract comprises the following steps: S1: Grind the dried whole dandelion to obtain a pulverized product, add 10-30 times the mass of the pulverized product and a 55-65wt% ethanol aqueous solution, stir at 40-55°C for 3-6 hours, filter, and cool to obtain product 1; S2: Product 1 is concentrated under reduced pressure to 5-20wt% of the mass of product 1 to obtain a concentrate, and an extractant composed of an oil phase and an aqueous phase in a mass ratio of 1:0.2-0.4 in an amount of 15-40 times the mass of the concentrate is added, and the mixture is stirred and extracted at 40-50° C. for 2-5 hours, and then allowed to stand for stratification, and the oil phase obtained by the stratification is taken as product 3; wherein the oil phase is composed of ethyl acetate and cyclohexane in a mass ratio of 1:2-3.5, and the aqueous phase is water; S3: Concentrate the product 3 under reduced pressure until no ethyl acetate and cyclohexane are detected, and then stop the reduced pressure concentration to obtain a dandelion extract.

2. The anti-crack repair composition containing Artemisia annua and camellia oil according to claim 1, characterized in that: In terms of mass percentage, the dosage of Artemisia annua extract is 0.008-1.5%.

3. The anti-crack repair composition containing Artemisia annua and camellia oil according to claim 1, characterized in that: According to the mass percentage, the dosage of camellia oil is 0.15-0.5%.

4. The anti-crack repair composition containing Artemisia annua and camellia oil according to claim 1, characterized in that: The mass ratio of purslane extract to dandelion extract is 1:0.8-1.

5.

5. The anti-crack repair composition containing Artemisia annua and camellia oil according to claim 1, characterized in that: According to mass percentage, the amount of urea used is 18-23%.

6. A method for preparing the anti-crack repair composition containing Artemisia annua and camellia oil according to any one of claims 1 to 5, characterized in that: The process includes mixing and sterilizing the raw materials.

7. Use of the anti-crack repairing composition containing Artemisia annua and camellia seed oil according to any one of claims 1 to 5 in the preparation of a preparation for preventing or treating skin cracks, characterized in that: The mass percentage of the anti-crack repair composition containing Artemisia annua and camellia seed oil in the preparation is 1-20%.

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