Traditional Chinese medicine liquid for treating scars and use method thereof

Abstract

The invention provides a traditional Chinese medicine liquid for treating scars and a use method thereof, and aims to solve the problem that the traditional Chinese medicine liquid cannot be stably stored for a long time. The invention relates to a traditional Chinese medicine liquid for treating scars and a use method thereof. The traditional Chinese medicine liquid is prepared from the following traditional Chinese medicine components: 2-4 parts of salvia miltiorrhiza, 1-3 parts of curcuma zedoary, 3-5 parts of oyster, 2-4 parts of honeysuckle, 1-3 parts of fructus forsythiae, 3-5 parts of astragalus membranaceus, 2-4 parts of angelica sinensis, 0.5-1.5 parts of frankincense and 0.5-1.5 parts of myrrh.

Description

Technical Field

[0001] The invention relates to the technical field of scar treatment, and in particular to a traditional Chinese medicine liquid for treating scar and a use method thereof. Background Art

[0002] Scars are abnormal tissues that continue to grow excessively after skin damage. They are hard and tough, red, and painful and itchy. Clinically, they are treated with physical methods such as surgical excision, local injection of hormone drugs, or laser treatment. The treatment cycle is long and the recurrence rate is high, which brings serious psychological and economic pressure to patients.

[0003] Traditional Chinese medicine has a long history of understanding the etiology and pathogenesis of scars. "Taiping Shenghui Fang·Missing Scars Prescriptions" records that "scars are all caused by wind-heat toxic gas, which is in the internal organs and rushes into the muscles, causing sores...it is advisable to apply disinfectant and scar-eliminating medicines", indicating that scars are mostly caused by dampness and heat in the body, and then trauma, evil qi invades the skin, causing qi stagnation and blood stasis, and scars over time. "Chinese Clinical Encyclopedia" records that "this disease is related to congenital endowment and body specificity, and in addition to being injured by metal, water and fire, the remaining toxins have not been cleared, qi stagnation and blood stasis, and the meridians are formed", indicating that clearing blood and removing blood stasis is the key to treatment.

[0004] The two most mature plasters currently used in clinical practice are black cloth plaster and gallnut scar cream. In addition, traditional Chinese medicine for the treatment of scars has a wide range of sources, complex ingredients, and a wide variety of active ingredients. In addition, the active ingredients of traditional Chinese medicine have been extensively studied, providing excellent conditions for the development of new drugs for scar treatment. However, most of them are still used in the form of plasters. Due to the characteristics of scar tissue, the permeability of drugs will be subject to certain restrictions. With the development of drug delivery technology, if the drug can be delivered through traditional Chinese medicine liquid and delivered to the inside of the scar tissue, the permeability of the drug and the therapeutic effect of the liquid on scars can be significantly improved.

[0005] However, it is challenging to prepare a Chinese medicine solution that can be stored stably for a long time. The main reason is that Chinese medicinal materials contain a variety of active ingredients such as flavonoids, alkaloids, volatile oils, polysaccharides, etc. These ingredients have great physical and chemical differences and may react with each other. Summary of the invention

[0006] The invention provides a traditional Chinese medicine liquid for treating scars and a use method thereof, so as to solve the problem that the traditional Chinese medicine liquid cannot be stably stored for a long time.

[0007] In order to achieve the above object, the present invention adopts the following technical solutions: A traditional Chinese medicine liquid for treating scars and a use method thereof. The traditional Chinese medicine liquid is prepared from the following traditional Chinese medicine formula: 2-4 parts of salvia miltiorrhiza, 1-3 parts of zedoaria, 3-5 parts of oyster, 2-4 parts of honeysuckle, 1-3 parts of forsythia, 3-5 parts of astragalus, 2-4 parts of angelica, 0.5-1.5 parts of frankincense and 0.5-1.5 parts of myrrh.

[0008] Furthermore, the Chinese medicine liquid is prepared from the following Chinese medicine formula: 15g of Salvia miltiorrhiza, 10g of Curcuma zedoaria, 30g of Oyster, 15g of Honeysuckle, 12g of Forsythia, 20g of Astragalus, 12g of Angelica sinensis, 6g of Frankincense, and 6g of Myrrh.

[0009] Furthermore, the preparation method of the Chinese medicine liquid is: S1: After crushing the oysters, add 450g of pure water, boil at 80℃ for 1-2h, and collect the filtrate after filtering with a filter and a microporous filter membrane; S2: Soaking salvia miltiorrhiza, zedoaria, golden yellow, forsythia, astragalus, angelica, frankincense, and myrrh in a 50% ethanol solution, wherein the drug-liquid ratio is 1:10, ultrasonically extracting at 40-60°C for 30 minutes, rapidly recovering ethanol by vacuum distillation at 40-50°C, and collecting the filtrate after filtering with a filter screen and a microporous filter membrane; S3: the liquids in step S1 and S2 are fully mixed, 0.5%-1% chitosan solution is added to the liquid, a precipitate is formed, and then centrifuged, and then filtered through a filter screen, a microporous filter membrane and an ultrafiltration membrane; S4: adding stabilizers and preservatives to the drug solution; S5: Use citric acid or sodium hydroxide solution to adjust the pH of the solution to between 5 and 7, and store the solution in a sealed container.

[0010] Furthermore, in step S4, 0.1-0.3% of ascorbic acid, 0.05-0.1% of disodium ethylenediaminetetraacetate and 0.01-0.05% of rosemary extract are added to the liquid medicine; 0.5% of potassium sorbate and sodium benzoate are added to the liquid medicine, and the ratio of potassium sorbate to sodium benzoate is 2:1.

[0011] Furthermore, the microporous filter membrane is a 0.45 μm and 0.22 μm microporous filter membrane, and the ultrafiltration membrane is an ultrafiltration membrane with a molecular weight cutoff of 5-10 kDa.

[0012] Furthermore, the method for using the Chinese medicine liquid is: heating the Chinese medicine liquid to 40-42° C. and soaking for 15-30 minutes.

[0013] Furthermore, the method for using the Chinese medicine liquid is: soak the sterile gauze in the Chinese medicine liquid, take it out after it is completely soaked, wring it slightly, and apply it on the surface of the scar.

[0014] Furthermore, the method for using the Chinese medicine liquid is: inserting the microneedle of the drug delivery device into the scar, injecting the Chinese medicine liquid into the drug delivery device, and the Chinese medicine liquid is transported to the inside of the scar through the microneedle.

[0015] Furthermore, the drug delivery device is composed of a microneedle layer and a hollow liquid-containing cavity fixed below the microneedle layer. The microneedles are arranged in an array through the microneedle layer, and the solution cavity has an injection port for injecting traditional Chinese medicine solution.

[0016] Furthermore, the microneedles include round microneedles for small-area scar tissue, flat microneedles for large-area scar tissue, and triangular pyramidal microneedles for thick and hard scar tissue.

[0017] Compared with the prior art, the present invention has the following beneficial effects: The present invention adopts a multi-stage filtration method, filtering through a filter screen, then filtering fine impurities with 0.45 μm and 0.22 μm microporous filter membranes respectively, and finally filtering with an ultrafiltration membrane with a molecular weight cutoff of 5-10 kDa. The multi-stage process removes impurities to the greatest extent and removes factors that affect the stability of the traditional Chinese medicine liquid to the greatest extent; The present invention uses a low-concentration ethanol solution for extraction, which ensures the extraction rate of fat-soluble effective ingredients and reduces the extraction of components that cause instability in the medicinal solution, such as salvianolic acid in Salvia miltiorrhiza, chlorogenic acid in honeysuckle, and forsythia suspensa in Forsythia suspensa. These components have strong reducing properties and are easily oxidized in high-concentration ethanol extraction. The oxidized phenolic compounds lose their original pharmacological activity, affecting the stability and efficacy of the medicinal solution. For example, in high-concentration ethanol extraction, tannins may be over-extracted, and they will aggregate and precipitate themselves during storage, affecting the stability of the medicinal solution. The present invention removes tannins through chitosan solution, which is relatively mild and can preferentially adsorb tannins, and has little effect on the effective ingredients in the liquid medicine, such as small molecule alkaloids and glycosides. After the tannins are removed, the liquid medicine will be clearer and the long-term stability of the liquid medicine will be enhanced. The present invention adopts a combined stabilizer and preservative, which has a better effect. Ascorbic acid can effectively protect the easily oxidized components in the medicinal solution, such as phenols, flavonoids and other effective ingredients. For example, for the medicinal solution containing Salvia miltiorrhiza, components such as salvianolic acid in Salvia miltiorrhiza are easily oxidized, and ascorbic acid can inhibit its oxidation process and maintain its pharmacological activity; disodium ethylenediaminetetraacetic acid can effectively bind to metal ions (carried by the medicinal materials themselves or residual in the equipment during processing) to make them lose their catalytic activity; for example, in the medicinal solution containing honeysuckle, components such as chlorogenic acid are easily oxidized in the presence of metal ions, and EDTA-2Na chelates metal ions and synergizes with ascorbic acid to greatly enhance the antioxidant capacity of the medicinal solution; rosemary extract can scavenge free radicals, interrupt oxidation chain reactions, and work with ascorbic acid and EDTA-2Na Form a multi-dimensional antioxidant system; for example, during the long-term storage of the liquid medicine, rosemary extract can continue to play an antioxidant role and further stabilize the composition of the liquid medicine; potassium sorbate mainly has a good inhibitory effect on molds, yeasts, etc., while sodium benzoate has a strong inhibitory ability against bacteria; a single preservative may have problems such as a narrow antibacterial spectrum and easy drug resistance; the combined use of potassium sorbate and sodium benzoate can broaden the antibacterial spectrum and reduce the risk of microbial resistance; The present invention further increases the stability time of the traditional Chinese medicine liquid by adjusting the pH value. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 is a schematic structural diagram of a drug delivery device according to embodiment 5 of the present invention; Figure 2 is a schematic diagram of the back structure of the drug delivery device of Example 5 of the present invention; Figure 3 is a schematic structural diagram of a drug delivery device according to embodiment 6 of the present invention; Figure 4 is a schematic diagram of the structure of a flat microneedle in the drug delivery device of Example 6 of the present invention; Figure 5 is a schematic structural diagram of a drug delivery device according to embodiment 7 of the present invention; Figure 6 It is a schematic diagram of the structure of the triangular cone microneedle in the drug delivery device of Example 7 of the present invention.

[0019] Among them, 10-microneedle layer, 20-liquid holding cavity, 110-bottom plate, 120-circular microneedle, 130-flat microneedle, 131-circular curve, 132-rounded rectangular curve, 140-triangular pyramidal microneedle, 141-first triangular curve, 142-second triangular curve, 210-cavity, 220-liquid injection port. DETAILED DESCRIPTION

[0020] The technical scheme of the present invention will be clearly and completely described below in conjunction with specific embodiments. Specific conditions not specified in the embodiments are carried out according to conventional conditions or recommended conditions in the literature such as standards. The reagents or instruments used, unless otherwise specified, are conventional products obtained through commercial channels.

[0021] The principles of Chinese medicine formula for treating scars should include: selecting Chinese medicine with the effects of promoting blood circulation and removing blood stasis, softening and dispersing nodules, to promote the softening and decomposition of scar tissue; selecting Chinese medicine with the effects of clearing away heat and detoxifying, antibacterial and anti-inflammatory, to prevent and control infection in the scar area and reduce inflammatory response; selecting Chinese medicine with the effects of replenishing qi and blood, promoting tissue regeneration and healing sores, to promote tissue repair and regeneration in the scar area.

[0022] Based on the above principles, the following ingredients are selected: Danshen: It has the effects of promoting blood circulation and removing blood stasis, cooling blood and eliminating carbuncle. Tanshinone and other ingredients in Danshen can improve local blood circulation and promote the metabolism and decomposition of scar tissue.

[0023] Curcuma: It has the effects of promoting blood circulation, promoting qi circulation, eliminating stagnation and relieving pain. Curcuma can inhibit the proliferation of scar tissue and promote its softening and absorption.

[0024] Oysters: They have the effect of softening and dispersing lumps. Components such as calcium carbonate in oysters can combine with collagen in scar tissue to soften and decompose it.

[0025] Honeysuckle: It has the effects of clearing away heat and detoxifying, and antibacterial and anti-inflammatory. The chlorogenic acid and other ingredients in honeysuckle can inhibit the growth of bacteria and viruses and reduce the inflammatory response in the scar area.

[0026] Forsythia: It has the effects of clearing away heat and detoxifying, reducing swelling and dispersing nodules. Forsythia and honeysuckle work synergistically to enhance the antibacterial and anti-inflammatory effects.

[0027] Astragalus: It has the functions of replenishing qi and raising yang, strengthening the body's defense system, and removing toxins and promoting tissue regeneration. Astragalus can improve the body's immunity and promote tissue repair and regeneration in scar areas.

[0028] Angelica: It has the effect of nourishing blood and activating blood circulation. Angelica can improve local blood circulation and provide nutritional support for the repair of scar tissue.

[0029] Frankincense and myrrh: They have the effects of promoting blood circulation, relieving pain, reducing swelling and promoting tissue regeneration. Frankincense and myrrh can promote blood circulation in scar areas and accelerate tissue repair and regeneration.

[0030] The Chinese medicine formula for scar treatment is composed of the following parts by weight: 2-4 parts of Salvia miltiorrhiza, 1-3 parts of Curcuma zedoaria, 3-5 parts of Oyster, 2-4 parts of Honeysuckle, 1-3 parts of Forsythia, 3-5 parts of Astragalus, 2-4 parts of Angelica sinensis, 0.5-1.5 parts of Frankincense, and 0.5-1.5 parts of Myrrh. Example 1

[0031] The Chinese medicine formula for scar treatment is as follows: Salvia miltiorrhiza 15g, Curcuma 10g, Oyster 30g, Honeysuckle 15g, Forsythia suspensa 12g, Astragalus 20g, Angelica sinensis 12g, Frankincense 6g, Myrrh 6g.

[0032] The method for preparing Chinese medicine liquid using the above Chinese medicine formula is as follows: S1: After crushing the oysters, add 450g of pure water, boil at 80℃ for 1-2h, and collect the filtrate after filtering with a filter and a microporous filter membrane; S2: Soaking salvia miltiorrhiza, zedoaria, golden yellow, forsythia, astragalus, angelica, frankincense, and myrrh in a 50% ethanol solution, wherein the drug-liquid ratio is 1:10, ultrasonically extracting at 40-60°C for 30 minutes, rapidly recovering ethanol by vacuum distillation at 40-50°C, and collecting the filtrate after filtering with a filter screen and a microporous filter membrane; S3: the liquids in step S1 and S2 are fully mixed, 0.5%-1% chitosan solution is added to the liquid, a precipitate is formed, and then centrifuged, and then filtered through a filter screen, a microporous filter membrane and an ultrafiltration membrane; S4: adding 0.1-0.3% ascorbic acid, 0.05-0.1% disodium ethylenediaminetetraacetate and 0.01-0.05% rosemary extract to the liquid medicine; adding 0.5% potassium sorbate and sodium benzoate to the liquid medicine, the ratio of potassium sorbate to sodium benzoate being 2:1; S5: Use citric acid or sodium hydroxide solution to adjust the pH of the solution to between 5 and 7, and store the solution in a sealed container.

[0033] Among them, the filtration adopts multi-stage filtration, first using a filter to remove large particles of impurities, then using 0.45μm and 0.22μm microporous filter membranes to filter fine impurities respectively, and finally filtering with an ultrafiltration membrane with a molecular weight cutoff of 5-10kDa. Example 2

[0034] Different from Example 1, the dosage of the Chinese medicine formula for scar treatment in this example is different: Salvia miltiorrhiza 20g, Curcuma 15g, Oyster 25g, Honeysuckle 20g, Forsythia suspensa 15g, Astragalus 30g, Angelica 20g, Frankincense 8g, Myrrh 8g. Example 3

[0035] Different from Example 1, the dosage of the Chinese medicine formula for scar treatment in this example is different: Salvia miltiorrhiza 10g, Curcuma 5g, Oyster 15g, Honeysuckle 10g, Forsythia suspensa 5g, Astragalus 15g, Angelica 10g, Frankincense 5g, Myrrh 5g. Example 4

[0036] This example is an accelerated stability test conducted on Examples 1-3 to test the stability of the Chinese medicine solution.

[0037] Place the drug solution in an environment with a temperature of 40℃±2℃ and a relative humidity of 75%±5% for 6 months, and observe it at the 0th, 1st, 2nd, 3rd, and 6th month. Observe the appearance of the drug solution, including color, clarity, whether there is precipitation or suspended matter, etc.; measure the pH value; and test the changes in the number of microorganisms in the drug solution according to the Chinese Pharmacopoeia. The specific results are shown in the following table.

[0038] Table 1: Accelerated stability test results of Example 1 Table 2: Accelerated stability test results of Example 2 Table 3: Accelerated stability test results of Example 3 Example 5

[0039] The method for using the Chinese medicine liquid of Example 1 comprises: Method 1: Soaking: Heat the Chinese medicine solution to 40-42℃ and soak for 15-30 minutes.

[0040] Method 2: Wet compress. Soak the sterile gauze in the Chinese medicine solution. After it is completely soaked, take it out, wring it slightly, and apply it on the scar surface.

[0041] The above two methods are relatively common. This embodiment provides a method for administering medication inside scars, which uses microneedles to deliver liquid medicine into the scar to solve the problem of poor drug permeability of traditional Chinese medicine ointments.

[0042] like Figure 1 and Figure 2 As shown, the drug delivery device is composed of a microneedle layer 10 and a liquid-containing cavity 20 fixedly connected to the microneedle layer 10, and the liquid-containing cavity 20 is used to contain Chinese medicine liquid. The microneedle layer 10 is composed of a bottom plate 110 and an array of circular microneedles 120 located on the bottom plate 110, and the bottom of the circular microneedles 120 penetrates the bottom plate 110. The bottom plate 110 can be made of hard material or soft material. Hard material is conducive to force, and soft material is suitable for arc scar tissue.

[0043] The liquid-containing cavity 20 is a hollow rectangular structure with an opening at the top, and the top is fixed on the bottom plate 110 of the microneedle layer 10. The main body of the liquid-containing cavity 20 is the cavity 210, and there is a liquid injection port 220 on the bottom surface of the cavity 210 for injecting the Chinese medicine liquid. The material of the cavity 210 is preferably a hard material on all sides, and the bottom surface is made of a soft material. The advantage of the soft material is that the Chinese medicine liquid can be pushed by squeezing the bottom surface inward. Example 6

[0044] Based on Example 5, the round microneedle 120 is replaced with a flat microneedle 130, such as Figure 3 and Figure 4As shown, the bottom of the needle tip of the flat microneedle 130 is a circular curve 131, and the upper end is a rounded rectangular curve 132. The flat microneedle 130 has a larger surface area, which can expand the range of tissues contacted by the Chinese medicine solution and improve the efficiency of drug administration. It is suitable for large-area scars. Large-area scar tissue refers to scars with an area exceeding 10cm×10cm. In contrast, scar tissue that does not exceed the above size is small-area scar tissue. Example 7

[0045] On the basis of Example 5, the circular microneedle 120 is replaced with a triangular pyramidal microneedle 140, such as Figure 5 and Figure 6 As shown, the lower end of the needle head of the triangular pyramidal microneedle 140 is a first triangular curve 141, and the upper end is a second triangular curve 142, and the first triangular curve 141 and the second triangular curve 142 are both equilateral triangles. The triangular pyramidal microneedle 140 has stronger penetrability and is suitable for thicker scar tissue. Thick and hard scar tissue refers to scar tissue with a thickness greater than or equal to 0.8 cm. Example 8

[0046] This example is a clinical trial conducted on the basis of Example 1, Example 5, Example 6 and Example 7.

[0047] Case 1: Zhang, female, 12 years old, had a 3cm×1cm nearly oval hypertrophic scar after being scalded by hot water on her arm. The scar was 0.3mm thick, red and hard, with exposed capillaries, accompanied by pain and itching. A round microneedle was used to administer medication into the scar once a day. It stopped itching after use. After 3 days, the scar showed signs of softening, so the medication was changed to once every other day. The scar loosened after 15 days. After loosening, Chinese medicine was directly applied every day until it was completely repaired. At 28 days, the scar had been repaired to be as smooth as normal skin.

[0048] Case 2: Mr. Li, male, 25 years old, had a pathological hyperplastic scar after a large area of ​​burn on his leg. The scar area was 18cm×10cm long and 0.5mm high. It was red and hard. Capillaries were exposed in some areas, and it was painful and itchy. Flat microneedles were used for drug administration every day. After drug administration, the pain and itching were significantly relieved. On the third day, some areas of the scar showed signs of softening. At this time, the drug administration was changed to every other day. After 30 days, the scar was significantly flattened and the drug administration was changed to once a week. On the days when the drug administration was not scheduled, the scar tissue could be directly applied with Chinese medicine liquid. At 26 weeks, the scar had been repaired to be as smooth as normal skin.

[0049] Case 3: Zhao, male, 8 years old, was scalded on his back by boiling water, resulting in a scar 7.5cm×4cm long, 0.8cm high, very hard, purple-red in color, accompanied by strong pain and itching. Triangular cone-shaped microneedles were used to administer medication to the scar, twice a day, and the pain and itching were significantly relieved after administration. The scar began to soften on the 5th day, and the medication was changed to once a day. The medication was continued for 15 days, and the scar was basically soft. The medication was changed to every other day. After 45 days of continuous medication, the scar was partially flattened, and the medication was changed to once a week. At 40 weeks, the scar was basically repaired to the same flatness as normal skin. On the days when medication is not scheduled, the scar tissue can be directly applied with Chinese medicine liquid. When it feels itchy or uncomfortable, it can be wet-compressed or wiped with Chinese medicine liquid.

[0050] The above embodiments are only used to illustrate the technical solution of the present invention, rather than to limit it. Based on the inventive concept of the present invention, those skilled in the art may make some modifications or substitutions thereto, and these modifications or substitutions shall be included in the protection scope of the present invention.

Claims

1. A Chinese medicine liquid for treating scars and a method of use, characterized in that: The Chinese medicine liquid is prepared from the following Chinese medicine formula: 2-4 parts of salvia miltiorrhiza, 1-3 parts of zedoaria, 3-5 parts of oyster, 2-4 parts of honeysuckle, 1-3 parts of forsythia, 3-5 parts of astragalus, 2-4 parts of angelica, 0.5-1.5 parts of frankincense and 0.5-1.5 parts of myrrh.

2. A Chinese medicine liquid for treating scars and a method of use according to claim 1, characterized in that: The Chinese medicine liquid is prepared from the following Chinese medicine formula: 15g of salvia miltiorrhiza, 10g of curcuma, 30g of oyster, 15g of honeysuckle, 12g of forsythia, 20g of astragalus, 12g of angelica, 6g of frankincense and 6g of myrrh.

3. A Chinese medicinal liquid for treating scars and a method of use according to claim 1 or 2, characterized in that: The preparation method of the Chinese medicine liquid is: S1: After crushing the oysters, add 450g of pure water, boil at 80℃ for 1-2h, and collect the filtrate after filtering with a filter and a microporous filter membrane; S2: Soaking salvia miltiorrhiza, zedoaria, golden yellow, forsythia, astragalus, angelica, frankincense, and myrrh in a 50% ethanol solution, wherein the drug-liquid ratio is 1:10, ultrasonically extracting at 40-60°C for 30 minutes, rapidly recovering ethanol by vacuum distillation at 40-50°C, and collecting the filtrate after filtering with a filter screen and a microporous filter membrane; S3: the liquids in step S1 and S2 are fully mixed, 0.5%-1% chitosan solution is added to the liquid, a precipitate is formed, and then centrifuged, and then filtered through a filter screen, a microporous filter membrane and an ultrafiltration membrane; S4: adding stabilizers and preservatives to the drug solution; S5: Use citric acid or sodium hydroxide solution to adjust the pH of the solution to between 5 and 7, and store the solution in a sealed container.

4. A Chinese medicinal liquid for treating scars and a method of use according to claim 3, characterized in that: In step S4, 0.1-0.3% of ascorbic acid, 0.05-0.1% of disodium ethylenediaminetetraacetate and 0.01-0.05% of rosemary extract are added to the liquid medicine; 0.5% of potassium sorbate and sodium benzoate are added to the liquid medicine, and the ratio of potassium sorbate to sodium benzoate is 2:

1.

5. A Chinese medicinal liquid for treating scars and a method of use according to claim 3, characterized in that: The microporous filter membranes are 0.45 μm and 0.22 μm microporous filter membranes, and the ultrafiltration membrane is an ultrafiltration membrane with a molecular weight cutoff of 5-10 kDa.

6. A Chinese medicinal liquid for treating scars and a method of use according to claim 1, characterized in that: The method for using the traditional Chinese medicine liquid is as follows: heating the traditional Chinese medicine liquid to 40-42° C. and soaking for 15-30 minutes.

7. A Chinese medicinal liquid for treating scars and a method of use according to claim 1, characterized in that: The method for using the traditional Chinese medicine liquid is as follows: soak the sterile gauze in the traditional Chinese medicine liquid, take it out after it is completely soaked, slightly wring it dry, and apply it on the surface of the scar.

8. A Chinese medicinal liquid for treating scars and a method of use according to claim 1, characterized in that: The method for using the Chinese medicine liquid is as follows: inserting the microneedle of the drug delivery device into the scar, injecting the Chinese medicine liquid into the drug delivery device, and transporting the Chinese medicine liquid to the inside of the scar through the microneedle.

9. A Chinese medicinal liquid for treating scars and a method of use according to claim 8, characterized in that: The drug delivery device is composed of a microneedle layer and a hollow liquid-containing cavity fixed below the microneedle layer. The microneedles are arranged in an array on the microneedle layer, and the solution cavity has a liquid injection port for injecting traditional Chinese medicine liquid.

10. A Chinese medicinal liquid for treating scars and a method of use according to claim 9, characterized in that: The microneedles include round microneedles for small-area scar tissue, flat microneedles for large-area scar tissue, and triangular pyramidal microneedles for thick and hard scar tissue.

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