Tea for relieving sphagitis and preparation method thereof

Abstract

The invention provides tea for relieving sphagitis. The tea is prepared by crushing and sterilizing the following raw materials in parts by weight: 5-20 parts of honeysuckle, 0.5-8 parts of hawthorn and 0.3-4 parts of momordica grosvenori. The invention further provides a preparation method, the honeysuckle, the hawthorn and the momordica grosvenori are sequentially screened, cleaned, subjected to impurity removal and dried, the dried honeysuckle, the dried hawthorn and the dried momordica grosvenori are mixed, smashed, sieved, subjected to superheated steam sterilization and naturally cooled to the room temperature, and the tea capable of relieving sphagitis is obtained, packaged and warehoused. The traditional Chinese medicine composition has good effects of clearing away heat and toxic materials, dispelling wind and heat, promoting the circulation of qi, moistening the lung, promoting the secretion of saliva or body fluid and relieving sore-throat, can better relieve various symptoms of sphagitis, and has a better health-preserving and health-care effect.

Description

Technical Field

[0001] The invention belongs to the technical field of health tea, and particularly relates to tea for relieving pharyngitis and a preparation method thereof. Background Art

[0002] Pharyngitis and laryngitis refer to inflammatory diseases of the pharynx and larynx caused by various reasons, which are called pharyngitis and laryngitis respectively. According to the duration of the disease, it can be divided into acute pharyngitis and chronic pharyngitis, acute laryngitis and chronic laryngitis. Because the pharynx and larynx are closely connected in location, pharyngitis can spread to the larynx and cause laryngitis, and laryngitis can also spread to the pharynx and cause pharyngitis. Therefore, people call this large category of diseases pharyngitis.

[0003] Common symptoms of pharyngitis include dry itching, sore throat, foreign body sensation in the throat, coughing and expectoration, hoarseness, etc. In severe cases, breathing difficulties may occur. Acute pharyngitis can be completely cured after removing the cause and taking regular treatment; however, chronic pharyngitis is mostly caused by repeated attacks of acute pharyngitis, excessive use of the vocal cords or stimulation such as smoking. It has the characteristics of long course, repeated attacks, and is not easy to cure. Its recurrence can only be minimized. Chronic pharyngitis is generally treated with lozenges such as Coral Grass Tablets and Silver Yellow Lozenges to relieve chronic inflammation of the pharyngeal mucosa; or Pudilan Anti-inflammatory Oral Liquid can be used to clear away heat and detoxify, reduce swelling and relieve sore throat, pharyngeal swelling, and pharyngeal congestion. These drugs can only relieve some of the symptoms of chronic pharyngitis. With the enhancement of people's awareness of health care, health tea has received widespread attention. There are many kinds of health teas and their patents on the market. These health teas are not only complex in formulation, but also generally have poor efficacy on acute pharyngitis and can only relieve some symptoms of chronic pharyngitis. For example, the patent containing medicinal materials such as Ophiopogon japonicus, Prunella vulgaris, honeysuckle, Scrophularia ningpoensis, and Sterculia lychnophora (application number CN202410757804.X) has a simple preparation method, but can only relieve some symptoms of pharyngitis. Another example is the patent containing medicinal materials such as chrysanthemum, honeysuckle, honeysuckle vine, scutellaria baicalensis, Paris polyphylla, Viola yedoensis, Imperatae rhizome, licorice, and mint (application number CN202311634361.7), although it is easy to use, the formula is complex and the efficacy is average. The tea patent (application number CN106889252A) prepared with ingredients such as 100-130 parts of water, 8-10 parts of Apocynum venetum tea, 1-2 parts of coffee beans, 1-2 parts of Pueraria root, 3-4 parts of hawthorn pulp, 2-3 parts of dried tangerine peel, 2-3 parts of Scutellaria baicalensis, and 2-3 parts of crystal sugar is inconvenient to use and has poor efficacy.

[0004] In summary, it is extremely important to develop a tea for relieving pharyngitis which has definite efficacy, simple preparation method and simple formula. Summary of the invention

[0005] The technical problem to be solved by the present invention is to provide a tea for relieving pharyngitis and a preparation method thereof in view of the deficiencies of the above-mentioned prior art. The tea for relieving pharyngitis is easy to prepare, has a simple formula, can better relieve various symptoms of pharyngitis, and has a better health care effect.

[0006] To solve the above technical problems, the technical solution adopted by the present invention is: a tea for relieving pharyngitis, which is made by crushing and sterilizing the following raw materials in parts by weight: 5 to 20 parts of honeysuckle, 0.5 to 8 parts of hawthorn, and 0.3 to 4 parts of monk fruit.

[0007] Preferably, the mixture is made from the following raw materials in parts by weight which are crushed and sterilized: 8 to 16 parts of honeysuckle, 1 to 6 parts of hawthorn, and 0.5 to 3 parts of momordica grosvenori.

[0008] Preferably, the mixture is made from the following raw materials in parts by weight which are crushed and sterilized: 10 parts of honeysuckle, 2 parts of hawthorn, and 1 part of momordica grosvenori.

[0009] The present invention also provides a method for preparing the above-mentioned tea for relieving pharyngitis and sore throat, which comprises: S1, respectively, screening, cleaning, removing impurities and drying honeysuckle, hawthorn and momordica grosvenori in turn to obtain dried honeysuckle, dried hawthorn and dried momordica grosvenori; S2, mixing the dried honeysuckle, dried hawthorn and dried momordica grosvenori obtained in S1, crushing and sieving to obtain medicinal material powder; S3, sterilizing the medicinal material powder obtained in S2 with superheated steam, and naturally cooling it to room temperature to obtain tea for relieving pharyngitis; S4. The tea for relieving pharyngitis obtained in S3 is measured and packaged into bags, divided into filter paper bags, sealed with plastic bags, measured into boxes, packed, inspected and put into storage.

[0010] Preferably, the screening in S2 is through a No. 4 sieve.

[0011] Preferably, the method of superheated steam sterilization in S3 is: sterilizing under steam conditions at a temperature of 160° C. for 10 seconds, and naturally cooling to room temperature.

[0012] Preferably, the amount of the tea for relieving pharyngitis in the bag package in S4 is 2 g / bag.

[0013] Compared with the prior art, the present invention has the following advantages: The honeysuckle in the present invention has the effects of clearing away heat and detoxifying, and dispersing wind-heat. The hawthorn has the effects of digesting food and strengthening the stomach, promoting qi and dispersing blood stasis, and removing turbidity and reducing fat. The Momordica grosvenori has the effects of clearing heat and moistening the lungs, relieving sore throat and opening voice, and smoothing the intestines and relieving constipation. The three are used together, and have good effects of clearing away heat and detoxifying, dispersing wind-heat, promoting qi and moistening the lungs, promoting body fluid and relieving sore throat, and can better alleviate the various symptoms of pharyngitis, such as dry and itchy throat, sore throat, foreign body sensation in the throat, cough and sputum, hoarseness, etc., and have good health care effects.

[0014] The present invention is further described in detail below in conjunction with embodiments. DETAILED DESCRIPTION

[0015] Example 1 The tea for relieving pharyngitis in this embodiment is prepared by crushing and sterilizing the following raw materials in parts by weight: 10 parts of honeysuckle, 2 parts of hawthorn, and 1 part of momordica grosvenori.

[0016] This embodiment also provides a method for preparing the above-mentioned tea for relieving pharyngitis and sore throat, which is: S1, screening, cleaning, removing impurities and drying honeysuckle, hawthorn and momordica grosvenori respectively, to obtain dried honeysuckle, dried hawthorn and dried momordica grosvenori respectively; S2, mixing the dried honeysuckle, dried hawthorn and dried momordica grosvenori obtained in S1, crushing and passing through a No. 4 sieve to obtain medicinal material powder; S3, sterilizing the medicinal material powder obtained in S2 with superheated steam, and naturally cooling to room temperature to obtain tea for relieving pharyngitis; the method of superheated steam sterilization is: sterilizing under steam conditions at a temperature of 160° C. for 10 seconds, and naturally cooling to room temperature; S4. The tea for relieving pharyngitis obtained in S3 is packaged into bags at a rate of 2 g / bag, divided into filter paper bags, sealed with plastic bags, and then measured into boxes, packed, inspected and put into storage.

[0017] The tea for relieving pharyngitis and laryngitis prepared in the present embodiment is soaked in boiling water for 15min, and a medicinal liquid containing 0.1g and 0.2g of crude drug per mL is made and stored in a volumetric flask. For patients with acute pharyngitis and acute laryngitis, the symptoms of dry and itchy throat can be significantly relieved in 1-3 days, and the symptoms such as throat pain, foreign body sensation in the pharynx, cough and sputum, and hoarseness can be significantly improved in 3-7 days. For patients with chronic pharyngitis and chronic laryngitis, the symptoms of dry and itchy throat can be significantly relieved in 1-3 days, and the symptoms such as throat pain, foreign body sensation in the pharynx, cough and sputum, and hoarseness can be significantly improved in 7-15 days.

[0018] Example 2 The tea for relieving pharyngitis of the present embodiment is characterized in that it is made from the following raw materials in parts by weight after being crushed and sterilized: 8 parts of honeysuckle, 1 part of hawthorn, and 3 parts of momordica grosvenori.

[0019] This embodiment also provides a method for preparing the above-mentioned tea for relieving pharyngitis, which is the same as the method in Example 1.

[0020] Soak in boiling water for 15 minutes to make a liquid containing 0.1g or 0.2g of crude drug per mL, and store in a volumetric flask. For patients with acute pharyngitis and acute laryngitis, the symptoms of dry and itchy throat can be significantly relieved in 1-3 days, and the symptoms of sore throat, foreign body sensation in the throat, cough and sputum, hoarseness, etc. can be significantly improved in 3-10 days. For patients with chronic pharyngitis and chronic laryngitis, the symptoms of dry and itchy throat can be significantly relieved in 1-3 days, and the symptoms of sore throat, foreign body sensation in the throat, cough and sputum, hoarseness, etc. can be significantly improved in 7-15 days.

[0021] Example 3 The tea for relieving pharyngitis of the present embodiment is characterized in that it is made from the following raw materials in parts by weight after being crushed and sterilized: 16 parts of honeysuckle, 6 parts of hawthorn, and 0.5 parts of momordica grosvenori.

[0022] This embodiment also provides a method for preparing the above-mentioned tea for relieving pharyngitis, which is the same as the method in Example 1.

[0023] Soak in boiling water for 15 minutes to make a liquid containing 0.1g or 0.2g of crude drug per mL, and store in a volumetric flask. For patients with acute pharyngitis and acute laryngitis, symptoms of dry and itchy throat and sore throat can be significantly relieved in 3-5 days, and pharyngitis can be significantly improved in 8-10 days.

[0024] Example 4 The tea for relieving pharyngitis of the present embodiment is characterized in that it is made from the following raw materials in parts by weight after being crushed and sterilized: 5 parts of honeysuckle, 8 parts of hawthorn, and 0.3 parts of momordica grosvenori.

[0025] This embodiment also provides a method for preparing the above-mentioned tea for relieving pharyngitis, which is the same as the method in Example 1.

[0026] Soak in boiling water for 15 minutes to make a liquid containing 0.1g or 0.2g of crude drug per mL, and store in a volumetric flask. For patients with acute pharyngitis and acute laryngitis, the symptoms of dry and itchy throat can be significantly relieved in 1-3 days, and the symptoms of sore throat, foreign body sensation in the throat, cough and sputum, hoarseness, etc. can be significantly improved in 3-10 days. For patients with chronic pharyngitis and chronic laryngitis, the symptoms of dry and itchy throat can be significantly relieved in 1-5 days, and the symptoms of sore throat, foreign body sensation in the throat, cough and sputum, hoarseness, etc. can be significantly improved in 10-20 days.

[0027] Example 5 The tea for relieving pharyngitis of the present embodiment is characterized in that it is made from the following raw materials in parts by weight after being crushed and sterilized: 20 parts of honeysuckle, 0.5 parts of hawthorn, and 4 parts of momordica grosvenori.

[0028] This embodiment also provides a method for preparing the above-mentioned tea for relieving pharyngitis, which is the same as the method in Example 1.

[0029] Soak in boiling water for 15 minutes to make a liquid containing 0.1g or 0.2g of crude drug per mL, and store in a volumetric flask. For patients with acute pharyngitis and acute laryngitis, the symptoms of dry and itchy throat can be significantly relieved in 1-3 days, and the symptoms of sore throat, foreign body sensation in the throat, cough and sputum, hoarseness, etc. can be significantly improved in 3-5 days. For patients with chronic pharyngitis and chronic laryngitis, the symptoms of dry and itchy throat can be significantly relieved in 1-3 days, and the symptoms of sore throat, foreign body sensation in the throat, cough and sputum, hoarseness, etc. can be significantly improved in 8-10 days.

[0030] Example 6 This embodiment is a pharmacodynamics experiment of the tea for relieving pharyngitis of the present invention.

[0031] 1.1 Preparation of tea for relieving pharyngitis 10 parts of honeysuckle, 2 parts of hawthorn and 1 part of momordica grosvenori were used to prepare 2 g of tea for relieving pharyngitis in each bag according to the preparation method of Example 1. Soaked in boiling water for 15 min to prepare a liquid containing 0.1 g and 0.2 g of crude drug per mL, which was stored in a volumetric flask for standby use.

[0032] 1.2 Experiment on inhibiting mouse capillary permeability 18-20 g mice, half male and half female, were randomly divided into groups according to body weight, and administered by gavage at 0.2 mL / 10 g body weight. One hour later, 0.5% Evans blue was injected into the tail vein at 0.1 mL / 10 g body weight, and each mouse was intraperitoneally injected with 0.2 mL of 0.6% HAC. After 20 minutes, the mice were killed by cervical dislocation, and the abdominal cavity was washed 3 times with 6 mL of normal saline. The washing solution was adjusted to 10 mL with normal saline, and centrifuged at 300 rpm for 15 minutes. The supernatant was taken and the OD value was measured colorimetrically at 590 nm by ultraviolet spectrophotometer. The results are shown in Table 1.

[0033] Table 1 Effects on capillary permeability in mice This experiment shows that the tea for relieving pharyngitis has a significant inhibitory effect on the permeability of mouse capillaries.

[0034] 1.3 Inhibition of inflammatory ear swelling in mice 18-20 g mice, half male and half female, were randomly divided according to body weight and administered by oral gavage at 0.2 mL / 10 g body weight. One hour later, 2% compound croton oil was applied to the right ear of the mice. Four hours later, the left and right ear pieces were punched out with a puncher and weighed with an electronic balance. The swelling rate and anti-inflammatory rate were calculated. The results are shown in Table 2.

[0035] Table 2 Effects on inflammatory ear swelling in mice This experiment showed that the tea for relieving pharyngitis has a significant anti-inflammatory effect on inflammatory ear swelling in mice.

[0036] 1.4 In vitro antibacterial experiment of tea for relieving pharyngitis Dilute the drug solution according to the two-fold dilution method, and place filter paper soaked with drug solutions of different concentrations on an agar plate covered with bacterial strains. o C for 24 h, and the colony growth was observed. The minimum inhibitory concentration of the drug solution is shown in Table 3.

[0037] Table 3 Minimum inhibitory concentration of tea for relieving pharyngitis This experiment shows that tea for relieving pharyngitis has a strong antibacterial effect.

[0038] 1.5 Effects on the rat acute pharyngitis model Sixty SPF SD rats were selected and randomly divided into 6 groups according to sex and weight, with 10 animals in each group. Except for the control group, the animals in the other groups were smeared with 2.5% ammonia water on the pharynx with a sterile cotton swab once a day for 7 consecutive days. The control group was smeared with normal saline in the same way. -1 The corresponding drug solution was given by gavage once a day for 7 consecutive days.

[0039] 1.5.1 Index detection ① Cough detection: 1 hour after the last administration, 10% ammonia solution was used to induce cough in rats, and a cough-inducing and wheezing instrument was used to detect the number of coughs and cough latency of rats in each group within 5 minutes.

[0040] Table 4 Effects of relieving pharyngitis tea on cough in rats with acute pharyngitis model Note: Compared with the control group, ##P<0.01; compared with the model group, *P<0.05, **P<0.01.

[0041] The experiment showed that the tea for relieving pharyngitis has a strong effect of enhancing the cough latency and reducing the number of coughs (Table 4).

[0042] ② Histopathological examination: On the day after the last administration, the patients were euthanized by bleeding from the abdominal aorta after inhalation anesthesia with isoflurane (1% to 4% for induction of anesthesia and 0.25% to 2% for maintenance of anesthesia). The pharyngeal tissue was dissected and fixed in 10% formaldehyde, embedded in paraffin, sliced, and stained with HE. The pathological changes of the pharyngeal tissue were observed under a microscope, and the scores were given based on mucosal congestion, vascular dilation and serous exudation, mucosal inflammatory cell infiltration, and mucosal swelling and thickening (Table 5). The specific scoring criteria are as follows: no obvious abnormality, scored as 0 points; mild, scored as 1 point; moderate, scored as 2 points; severe, scored as 3 points.

[0043] Table 5 Effect of tea for relieving pharyngitis on pathological scores of rat pharyngeal tissue The experiment shows that tea for relieving pharyngitis has a good effect in relieving mucosal congestion, vasodilation and serous exudation, mucosal inflammatory cell infiltration, and mucosal swelling and thickening.

[0044] The tea for relieving pharyngitis of the present invention has good effects of clearing away heat and detoxifying, evacuating wind-heat, promoting qi and moistening the lungs, promoting the production of body fluid and relieving throat pain, and can effectively relieve various symptoms of pharyngitis, such as dry and itchy throat, sore throat, foreign body sensation in the throat, coughing and expectoration, hoarseness and the like, and has good health-care effect.

[0045] The above is only a preferred embodiment of the present invention and does not limit the present invention in any way. Any simple modification, change and equivalent change made to the above embodiment according to the technical essence of the invention still falls within the protection scope of the technical solution of the present invention.

Claims

1. A tea for relieving pharyngitis, characterized in that: The invention is prepared by crushing and sterilizing the following raw materials in parts by weight: 5 to 20 parts of honeysuckle, 0.5 to 8 parts of hawthorn, and 0.3 to 4 parts of momordica grosvenori.

2. A tea for relieving pharyngitis according to claim 1, characterized in that: The invention is prepared by crushing and sterilizing the following raw materials in parts by weight: 8 to 16 parts of honeysuckle, 1 to 6 parts of hawthorn, and 0.5 to 3 parts of momordica grosvenori.

3. A tea for relieving pharyngitis according to claim 2, characterized in that: The following raw materials in parts by weight are crushed and sterilized: 10 parts of honeysuckle, 2 parts of hawthorn, and 1 part of momordica grosvenori.

4. A method for preparing the tea for relieving pharyngitis as claimed in any one of claims 1 to 3, characterized in that: The method is: S1, respectively, screening, cleaning, removing impurities and drying honeysuckle, hawthorn and momordica grosvenori in turn to obtain dried honeysuckle, dried hawthorn and dried momordica grosvenori; S2, mixing the dried honeysuckle, dried hawthorn and dried momordica grosvenori obtained in S1, crushing and sieving to obtain medicinal material powder; S3, sterilizing the medicinal material powder obtained in S2 with superheated steam, and naturally cooling it to room temperature to obtain tea for relieving pharyngitis; S4. The tea for relieving pharyngitis obtained in S3 is measured and packaged into bags, divided into filter paper bags, sealed with plastic bags, measured into boxes, packed, inspected and put into storage.

5. The method according to claim 4, characterized in that The sieving in S2 is through a No. 4 sieve.

6. The method according to claim 4, characterized in that The method of superheated steam sterilization described in S3 is: sterilize for 10 seconds under steam conditions at a temperature of 160° C., and cool naturally to room temperature.

7. The method according to claim 4, characterized in that The amount of the tea for relieving pharyngitis in the bag package described in S4 is 2 g / bag.

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