Hydrogel traditional Chinese medicine eye pad capable of improving eyesight, soothing nerves and relieving eyestrain and preparation method of hydrogel traditional Chinese medicine eye pad

Abstract

The preparation method comprises the following steps: 1, mixing fructus forsythiae, glossy privet fruits, chamomile flowers, mulberry leaves, mint, radix rehmanniae, selfheal, spina date seeds and polygala tenuifolia, adding water, and sequentially decocting, cooling, filtering, concentrating and sterilizing to obtain traditional Chinese medicine effective components; 2, adding powdered sodium alginate into water, heating and stirring to obtain an A-phase solution, sequentially adding gelatin, methylparaben and glycerol into water, heating and stirring to obtain a mixed solution, then adding sorbitol, continuously heating and stirring to obtain a B-phase solution, respectively standing the A-phase solution and the B-phase solution, and uniformly mixing to obtain hydrogel; and 3, adding the traditional Chinese medicine effective components into the hydrogel, uniformly stirring to obtain the hydrogel containing the traditional Chinese medicine effective components, pouring the hydrogel into an eye pad mold, dropwise adding the cross-linking agent solution, refrigerating and standing, and demolding to obtain the hydrogel traditional Chinese medicine eye pad which can effectively relieve asthenopia and has the effects of improving eyesight and soothing the nerves.

Description

Technical Field

[0001] The invention relates to an eye patch, in particular to a hydrogel Chinese medicine eye patch for improving eyesight, calming nerves and relieving eye fatigue and a preparation method thereof. Background Art

[0002] With the popularity of electronic devices, long-term use of electronic devices leads to excessive eye strain, which is prone to symptoms such as dryness, anxiety and insomnia. In severe cases, it will cause a gradual decline in vision, seriously affecting daily work and study. Although there are steam eye masks on the market to relieve eye fatigue, steam eye masks mainly relieve visual fatigue by promoting blood circulation. Not only is the effect of relieving eye fatigue unsatisfactory, but it also does not have the effect of improving eyesight and calming the mind.

[0003] Some existing Chinese medicinal materials have unique advantages in eye protection. Through the combination of multiple medicinal materials, they can effectively regulate eye function and achieve the effects of improving eyesight and calming the mind. Therefore, it is expected to prepare a Chinese medicinal eye patch that can improve eyesight, calm the mind and relieve eye fatigue. Summary of the invention

[0004] In view of the deficiencies in the prior art, the purpose of the present invention is to provide a hydrogel Chinese medicine eye patch that can improve eyesight, soothe the nerves and relieve eye fatigue, and a preparation method thereof. The prepared hydrogel Chinese medicine eye patch can effectively relieve visual fatigue and play a role in improving eyesight and soothing the nerves.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions:

[0006] A method for preparing a hydrogel Chinese medicine eye patch for improving eyesight, calming the nerves and relieving eye fatigue comprises the following steps:

[0007] Step 1: Extract the active ingredients of traditional Chinese medicine

[0008] Step 1.1, weigh 2-10g of Forsythia suspensa, 5-15g of Ligustrum lucidum fruit, 3-10g of chamomile flower, 3-10g of mulberry leaf, 1-5g of mint, 3-10g of Radix Rehmanniae, 2-12g of Prunella vulgaris, 1-8g of Semen Ziziphi spinulosae and 2-10g of Polygala tenuifolia, mix and obtain a Chinese medicine raw material;

[0009] Step 1.2, first add the Chinese medicine raw materials into a round-bottom flask, then add 20 to 40 times the weight of the Chinese medicine raw materials into the round-bottom flask. Boil, cool to room temperature, filter, and collect the liquid medicine;

[0010] Step 1.3, concentrating the medicinal liquid and sterilizing it at high temperature, and after cooling naturally, obtaining the effective ingredients of the traditional Chinese medicine, and refrigerating them for later use;

[0011] Step 2: Preparation of hydrogel

[0012] Step 2.1, weigh 1-3 g of powdered sodium alginate, add it to 60-130 times of its weight of water, heat and stir to fully dissolve it, and obtain a phase A solution;

[0013] Step 2.2, weigh 5-15 g of gelatin, 0.1-1 g of methylparaben and 2-10 g of glycerol, add them to water 3-10 times the weight of the total of gelatin, methylparaben and glycerol, heat and stir until there are no transparent particles, to obtain a mixed solution, then add 1-4 g of sorbitol to the mixed solution, continue heating and stirring to fully dissolve it, to obtain a phase B solution;

[0014] Step 2.3, firstly allowing the phase A solution and the phase B solution to stand separately, then mixing the phase A solution and the phase B solution, stirring to make them evenly mixed, to obtain a hydrogel;

[0015] Step 3: Preparation of hydrogel Chinese medicine eye patch

[0016] Step 3.1, adding the effective ingredients of traditional Chinese medicine to the hydrogel according to the mass ratio of (5-20):100, stirring evenly, to obtain a hydrogel containing the effective ingredients of traditional Chinese medicine;

[0017] Step 3.2: Pour the hydrogel containing the effective ingredients of traditional Chinese medicine into the eye patch mold, and after it stops flowing, drop 10% to 20% of its weight and a cross-linker solution with a concentration of 1wt% to 1.5wt%, let it stand at 4°C for 2 to 6 hours, and demold to obtain the hydrogel traditional Chinese medicine eye patch.

[0018] Furthermore, the decoction process in step 1.2 is as follows: firstly heat the round-bottom flask containing the Chinese medicine raw materials and water at 90-95° C., and after the water boils, switch to a temperature of 55-65° C. and heat for 1.5-3 hours.

[0019] Furthermore, the room temperature of step 1.2 is 20-30°C.

[0020] Furthermore, the concentration in step 1.3 is carried out by using a rotary evaporator at 60° C. and a rotation speed of 50 rpm for 1 to 3 hours to concentrate the drug solution to 1 / 6 to 1 / 4 of its original volume.

[0021] Furthermore, the high temperature sterilization in step 1.3 is performed at 110-125° C. for 15-25 minutes.

[0022] Furthermore, the heating temperature in step 2.1 is 55-58°C.

[0023] Furthermore, the heating temperature in step 2.2 is 58-70°C.

[0024] Furthermore, the standing in step 2.3 is to place the phase A solution and the phase B solution in a water bath at 60° C. respectively and stand for 10 minutes.

[0025] Furthermore, in step 3.2, the cross-linking agent solution is a calcium chloride solution or a calcium lactate solution.

[0026] A hydrogel Chinese medicine eye patch for improving eyesight, calming the mind and relieving eye fatigue.

[0027] Compared with the prior art, the present invention has the following technical effects:

[0028] The invention prepares a hydrogel Chinese medicine eye patch by combining various Chinese herbal medicines, extracting effective ingredients of Chinese medicines through decoction and concentration, and then using a hydrogel with strong water retention and good sustained release as a loading material, mixing the effective ingredients of Chinese medicines with the hydrogel, and utilizing the synergistic effect between various effective ingredients of Chinese medicines to promote blood circulation in the eyes, relax eye muscles and nerves, and achieve the purpose of improving vision, relieving eye fatigue, improving eyesight and calming the mind. The reason is that: Forsythia, chamomile and Prunella vulgaris have the effects of clearing away heat and detoxifying, reducing swelling and dispersing knots, and clearing the liver and purging fire The liver opens up to the eyes, and the liver is closely related to the eyes. Therefore, Forsythia suspensa, chamomile and Prunella vulgaris can be used to relieve eye discomfort caused by liver fire and liver blood consumption caused by staying up late and overusing the eyes; mulberry leaves have the effect of dispersing wind-heat and clearing the liver and improving eyesight; mint can clear the head and eyes, thereby relieving dryness and pain in the eyes; Ligustrum lucidum can nourish the yin of the liver and kidneys; Rehmannia glutinosa has the effects of clearing heat and cooling blood, nourishing yin and promoting fluid production, and can relieve blurred vision caused by yin deficiency and fire, thereby moisturizing the eyes; Ziziphus jujuba seeds have the effects of nourishing the heart and liver, calming the mind and promoting fluid production. , which can calm the mind and improve eyesight; Polygala can calm the mind, improve intelligence and reduce swelling, thereby relieving eye inflammation; therefore, through the combination of various medicinal materials, Forsythia suspensa and Prunella vulgaris can effectively relieve eye inflammation and eye pain, and play an anti-inflammatory role, and then Rehmannia glutinosa and Ligustrum lucidum can deliver nutrients to the eyes, which can effectively restore the damage and consumption of local eye tissues caused by inflammation and dryness, and can protect the eyes, while mulberry leaves, chamomile and mint can improve eye microcirculation, dilate eye blood vessels, remove metabolites and promote eye tissue The ingredients can regulate the local nerve tissue and relax the eye nerves. Each component can work together from multiple dimensions, such as anti-inflammation, nerve regulation, nutrition supplement, promotion and improvement of absorption, with its own active substances. With the help of the good water retention and sustained-release properties of hydrogel, the effective ingredients of traditional Chinese medicine can act on the eyes for a longer time, thus improving the skin's absorption of drugs and alleviating the eye discomfort caused by excessive use of eyes and staying up late. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 This is a real photo of the hydrogel Chinese medicine eye patch prepared by the present invention. DETAILED DESCRIPTION

[0030] The specific contents of the present invention are further explained in detail below in conjunction with embodiments.

[0031] In the process of selecting various Chinese medicinal materials in Examples 1 to 5 of the present invention, it is required that the colors of the raw materials in each Chinese medicinal material are similar with small differences. If the medicinal material is large, it needs to be cut into slices of appropriate size for easy decoction.

[0032] In the process of concentrating the drug solution in Examples 1 to 5 of the present invention, the drug solution is concentrated to 1 / 6 to 1 / 4 of its original volume by rotary evaporation.

[0033] The actual photos of the hydrogel Chinese medicine eye patch prepared in Examples 1 to 5 of the present invention are as follows Figure 1 shown.

[0034] Example 1

[0035] Step 1: Extract the active ingredients of traditional Chinese medicine

[0036] Step 1.1, weigh 2g of Forsythia suspensa, 10g of Ligustrum lucidum fruit, 3g of chamomile flower, 3g of mulberry leaf, 1g of mint, 5g of Radix Rehmanniae, 2g of Prunella vulgaris, 1g of Semen Ziziphi spinulosae and 2g of Polygala tenuifolia, mix and obtain a Chinese medicine raw material;

[0037] Step 1.2, first add the Chinese medicine raw materials into a round-bottom flask, then add 20 times the weight of water into the round-bottom flask, first heat the round-bottom flask containing the Chinese medicine raw materials and water at 90°C, after the water boils, switch to 55°C, heat for 3h, wait until it cools to 25°C, then filter out the large volume of drug residues with a filter, then filter out the small volume of drug residues with eight layers of gauze, and collect the drug solution;

[0038] Step 1.3, transfer the drug solution to a round-bottom flask, connect the round-bottom flask to a rotary evaporator, perform rotary evaporation and concentration at 60°C and 50 rpm for 1 hour, collect the concentrate, put it into a sterilizing pot, sterilize it at 121°C for 15 minutes, cool it, obtain the effective ingredients of the traditional Chinese medicine, put it into a refrigerator, and refrigerate it at 4°C for later use;

[0039] Step 2: Preparation of hydrogel

[0040] Step 2.1, weigh 2 g of powdered sodium alginate, add it into a beaker filled with 80 times its weight of water, place the beaker in a 55°C water bath, stir to completely dissolve the sodium alginate, and obtain a phase A solution;

[0041] Meanwhile, 5 g of gelatin, 0.1 g of methylparaben and 2 g of glycerin were weighed, and then water in an amount three times the weight of the sum of the weights of gelatin, methylparaben and glycerin was added to a beaker, and then gelatin, methylparaben and glycerin were added to the beaker in sequence, and the beaker was placed in a 70° C. water bath, heated and stirred until no transparent particles were present, to obtain a mixed solution, and then 1 g of sorbitol was added to the mixed solution, and the mixture was continued to be stirred in a 70° C. water bath to fully dissolve the mixture, to obtain a phase B solution;

[0042] Step 2.2, placing the phase A solution and the phase B solution in a water bath at 60° C. respectively, standing for 10 min, and then mixing the phase A solution and the phase B solution and stirring them evenly to obtain a hydrogel;

[0043] Step 3: Preparation of hydrogel Chinese medicine eye patch

[0044] Step 3.1, adding the effective ingredients of traditional Chinese medicine to the hydrogel at a mass ratio of 5:100, stirring evenly, to obtain a hydrogel containing the effective ingredients of traditional Chinese medicine;

[0045] Step 3.2: Pour the hydrogel containing the effective ingredients of traditional Chinese medicine into the eye patch mold. After it stops flowing, drop 10% of its weight of a 1wt% calcium lactate solution into the mold. Place the solution in a refrigerator at 4°C for 2 hours and demold to obtain a hydrogel traditional Chinese medicine eye patch.

[0046] Example 2

[0047] Step 1: Extract the active ingredients of traditional Chinese medicine

[0048] Step 1.1, weigh 4g of Forsythia suspensa, 5g of Ligustrum lucidum fruit, 5g of chamomile flower, 6.5g of mulberry leaf, 2g of mint, 8g of Radix Rehmanniae, 7g of Prunella vulgaris, 8g of Semen Ziziphi spinulosae and 4g of Polygala tenuifolia, mix and obtain a Chinese medicine raw material;

[0049] Step 1.2, first add the Chinese medicine raw materials into a round-bottom flask, then add 20 times the weight of water into the round-bottom flask, first heat the round-bottom flask containing the Chinese medicine raw materials and water at 95°C, after the water boils, switch to 60°C, heat for 1.5h, wait until it cools to 25°C, then filter out the large volume of drug residues with a filter, then filter out the small volume of drug residues with eight layers of gauze, and collect the drug solution;

[0050] Step 1.3, transfer the drug solution to a round-bottom flask, connect the round-bottom flask to a rotary evaporator, perform rotary evaporation and concentration at 60°C and 50 rpm for 1.5 h, collect the concentrate, put it into a sterilizing pot, sterilize it at 125°C for 20 min, cool it, obtain the effective ingredients of the traditional Chinese medicine, put it into a refrigerator, and refrigerate it at 4°C for later use;

[0051] Step 2: Preparation of hydrogel

[0052] Step 2.1, weigh 1 g of powdered sodium alginate, add it into a beaker filled with 100 times its weight of water, place the beaker in a 55°C water bath, stir to completely dissolve the sodium alginate, and obtain a phase A solution;

[0053] Meanwhile, 10 g of gelatin, 0.3 g of methylparaben and 8 g of glycerin were weighed, and then water in an amount three times the weight of the sum of the weights of gelatin, methylparaben and glycerin was added to a beaker, and then gelatin, methylparaben and glycerin were added to the beaker in sequence, and the beaker was placed in a 58° C. water bath, heated and stirred until no transparent particles were present, to obtain a mixed solution, and then 2 g of sorbitol was added to the mixed solution, and the mixture was continued to be stirred in a 58° C. water bath to fully dissolve the mixture, to obtain a phase B solution;

[0054] Step 2.2, placing the phase A solution and the phase B solution in a water bath at 60° C. respectively, standing for 10 min, and then mixing the phase A solution and the phase B solution and stirring them evenly to obtain a hydrogel;

[0055] Step 3: Preparation of hydrogel Chinese medicine eye patch

[0056] Step 3.1, adding the effective ingredients of traditional Chinese medicine to the hydrogel at a mass ratio of 15:100, stirring evenly to obtain a hydrogel containing the effective ingredients of traditional Chinese medicine;

[0057] Step 3.2: Pour the hydrogel containing the effective ingredients of traditional Chinese medicine into the eye patch mold. After it stops flowing, add 15% of its weight of a 1.3wt% calcium chloride solution. Place it in a refrigerator at 4°C for 5 hours, demold it, and obtain the hydrogel traditional Chinese medicine eye patch.

[0058] Example 3

[0059] Step 1: Extract the active ingredients of traditional Chinese medicine

[0060] Step 1.1, weigh 6g of Forsythia suspensa, 8g of Ligustrum lucidum fruit, 8g of chamomile flower, 5g of mulberry leaf, 4g of mint, 10g of Radix Rehmanniae, 10g of Prunella vulgaris, 6g of Semen Ziziphi spinulosae and 6g of Polygala tenuifolia, mix and obtain a Chinese medicine raw material;

[0061] Step 1.2, first add the Chinese medicine raw materials into a round-bottom flask, then add 30 times the weight of water of the Chinese medicine raw materials into the round-bottom flask, first heat the round-bottom flask containing the Chinese medicine raw materials and water at 95°C, after the water boils, switch to 60°C, heat for 2h, wait until it cools to 20°C, then filter out the large volume of drug residues with a filter, then filter out the small volume of drug residues with eight layers of gauze, and collect the drug liquid;

[0062] Step 1.3, transfer the drug solution to a round-bottom flask, connect the round-bottom flask to a rotary evaporator, perform rotary evaporation and concentration at 60°C and 50 rpm for 2 hours, collect the concentrate, put it into a sterilizing pot, sterilize it at 110°C for 25 minutes, cool it, obtain the effective ingredients of the traditional Chinese medicine, put it into a refrigerator, and refrigerate it at 4°C for later use;

[0063] Step 2: Preparation of hydrogel

[0064] Step 2.1, weigh 1.5 g of powdered sodium alginate, add it into a beaker filled with 120 times its weight of water, place the beaker in a 56°C water bath, stir to completely dissolve the sodium alginate, and obtain a phase A solution;

[0065] Meanwhile, 8 g of gelatin, 0.5 g of methylparaben and 4 g of glycerin were weighed, and then 10 times the weight of water of the sum of the weight of gelatin, methylparaben and glycerin was added to a beaker, and then gelatin, methylparaben and glycerin were added to the beaker in sequence, and the beaker was placed in a 60° C. water bath, heated and stirred until there were no transparent particles, to obtain a mixed solution, and then 3 g of sorbitol was added to the mixed solution, and the mixture was continued to be stirred in a 60° C. water bath to fully dissolve it, to obtain a phase B solution;

[0066] Step 2.2, placing the phase A solution and the phase B solution in a water bath at 60° C. respectively, standing for 10 min, and then mixing the phase A solution and the phase B solution and stirring them evenly to obtain a hydrogel;

[0067] Step 3: Preparation of hydrogel Chinese medicine eye patch

[0068] Step 3.1, adding the effective ingredients of traditional Chinese medicine to the hydrogel at a mass ratio of 20:100, stirring evenly, to obtain a hydrogel containing the effective ingredients of traditional Chinese medicine;

[0069] Step 3.2: Pour the hydrogel containing the effective ingredients of traditional Chinese medicine into the eye patch mold. After it stops flowing, add 20% of its weight of a 1.3wt% calcium chloride solution. Place it in a refrigerator at 4°C for 4 hours, demold it, and obtain the hydrogel traditional Chinese medicine eye patch.

[0070] Example 4

[0071] Step 1: Extract the active ingredients of traditional Chinese medicine

[0072] Step 1.1, weigh 8g of Forsythia suspensa, 12g of Ligustrum lucidum fruit, 10g of chamomile flower, 8g of mulberry leaf, 3g of mint, 6.5g of Radix Rehmanniae, 6g of Prunella vulgaris, 3g of Semen Ziziphi spinulosae and 8g of Polygala tenuifolia, mix and obtain a Chinese medicine raw material;

[0073] Step 1.2, first add the Chinese medicine raw materials into a round-bottom flask, then add 30 times the weight of water into the round-bottom flask, heat the round-bottom flask containing the Chinese medicine raw materials and water at 90°C, and after the water boils, switch to 60°C for 2.5h, and wait until it cools to 20°C, then filter out the large volume of drug residues with a filter, and then filter out the small volume of drug residues with eight layers of gauze, and collect the drug solution;

[0074] Step 1.3, transfer the drug solution to a round-bottom flask, connect the round-bottom flask to a rotary evaporator, perform rotary evaporation and concentration at 60°C and 50 rpm for 3 hours, collect the concentrate, put it into a sterilizing pot, sterilize it at 121°C for 20 minutes, cool it, obtain the effective ingredients of the traditional Chinese medicine, put it into a refrigerator, and refrigerate it at 4°C for later use;

[0075] Step 2: Preparation of hydrogel

[0076] Step 2.1, weigh 2.5 g of powdered sodium alginate, add it into a beaker filled with 60 times its weight of water, place the beaker in a 57°C water bath, stir to completely dissolve the sodium alginate, and obtain a phase A solution;

[0077] Meanwhile, 13 g of gelatin, 0.8 g of methylparaben and 6 g of glycerin were weighed, and then 7 times of the total weight of water of gelatin, methylparaben and glycerin were added to a beaker, and then gelatin, methylparaben and glycerin were added to the beaker in sequence, and the beaker was placed in a water bath at 68° C., heated and stirred until no transparent particles were present, to obtain a mixed solution, and then 2.5 g of sorbitol was added to the mixed solution, and the mixture was stirred in a water bath at 68° C. to fully dissolve the mixture, to obtain a phase B solution;

[0078] Step 2.2, placing the phase A solution and the phase B solution in a water bath at 60° C. respectively, standing for 10 min, and then mixing the phase A solution and the phase B solution and stirring them evenly to obtain a hydrogel;

[0079] Step 3: Preparation of hydrogel Chinese medicine eye patch

[0080] Step 3.1, adding the effective ingredients of traditional Chinese medicine to the hydrogel at a mass ratio of 10:100, stirring evenly, to obtain a hydrogel containing the effective ingredients of traditional Chinese medicine;

[0081] Step 3.2: Pour the hydrogel containing the effective ingredients of traditional Chinese medicine into the eye patch mold, and after it stops flowing, drop 10% of its weight of a 1.5wt% calcium lactate solution into the mold, let it stand in a refrigerator at 4°C for 6 hours, and demold to obtain a hydrogel traditional Chinese medicine eye patch.

[0082] Example 5

[0083] Step 1: Extract the active ingredients of traditional Chinese medicine

[0084] Step 1.1, weigh 10g of Forsythia suspensa, 15g of Ligustrum lucidum fruit, 6.5g of chamomile flower, 10g of mulberry leaf, 5g of mint, 3g of Radix Rehmanniae, 12g of Prunella vulgaris, 4.5g of Semen Ziziphi spinulosae and 10g of Polygala tenuifolia, mix and obtain a Chinese medicine raw material;

[0085] Step 1.2, first add the Chinese medicine raw materials into a round-bottom flask, then add 40 times the weight of water of the Chinese medicine raw materials into the round-bottom flask, first heat the round-bottom flask containing the Chinese medicine raw materials and water at 92°C, after the water boils, switch to 65°C, heat for 1.5h, wait until it cools to 30°C, then filter out the large volume of drug residues with a filter, then filter out the small volume of drug residues with eight layers of gauze, and collect the drug solution;

[0086] Step 1.3, transfer the drug solution to a round-bottom flask, connect the round-bottom flask to a rotary evaporator, perform rotary evaporation and concentration at 60°C and 50 rpm for 2.5 hours, collect the concentrate, put it into a sterilizing pot, sterilize it at 115°C for 20 minutes, cool it, obtain the effective ingredients of the traditional Chinese medicine, put it into a refrigerator, and refrigerate it at 4°C for later use;

[0087] Step 2: Preparation of hydrogel

[0088] Step 2.1, weigh 3 g of powdered sodium alginate, add it into a beaker filled with 130 times its weight of water, place the beaker in a 58°C water bath, stir to completely dissolve the sodium alginate, and obtain a phase A solution;

[0089] Meanwhile, 15 g of gelatin, 1 g of methylparaben and 10 g of glycerin were weighed, and then 5 times of the total weight of water of gelatin, methylparaben and glycerin were added to a beaker, and then gelatin, methylparaben and glycerin were added to the beaker in sequence, and the beaker was placed in a water bath at 65° C., heated and stirred until no transparent particles were present, to obtain a mixed solution, and then 4 g of sorbitol was added to the mixed solution, and the mixture was stirred in a water bath at 65° C. to fully dissolve the mixture, to obtain a phase B solution;

[0090] Step 2.2, placing the phase A solution and the phase B solution in a water bath at 60° C. respectively, standing for 10 min, and then mixing the phase A solution and the phase B solution and stirring them evenly to obtain a hydrogel;

[0091] Step 3: Preparation of hydrogel Chinese medicine eye patch

[0092] Step 3.1, adding the effective ingredients of traditional Chinese medicine to the hydrogel at a mass ratio of 12.5:100, stirring evenly, to obtain a hydrogel containing the effective ingredients of traditional Chinese medicine;

[0093] Step 3.2: Pour the hydrogel containing the effective ingredients of traditional Chinese medicine into the eye patch mold. After it stops flowing, add 15% of its weight and a 1.5wt% calcium chloride solution. Place it in a refrigerator at 4°C for 5 hours, demold it, and obtain the hydrogel traditional Chinese medicine eye patch.

[0094] Comparative Example 1

[0095] The difference from Example 2 is that the mass ratio of the effective ingredients of traditional Chinese medicine to the hydrogel in step 3.1 is 30:100.

[0096] Comparative Example 2

[0097] The difference from Example 2 is that the mass ratio of sodium alginate to water in step 2.1 is 5:150.

[0098] Comparative Example 3

[0099] The difference from Example 2 is that the cross-linking agent used in step 3.2 is a calcium chloride solution with a concentration of 3 wt%.

[0100] 16 volunteers who were engaged in long-term work requiring the use of computers and other electronic products were selected, including 9 males and 7 females, aged between 23 and 45 years old. The 16 volunteers were randomly divided into 8 groups, and the hydrogel Chinese medicine eye patches prepared in Examples 1 to 5 and Comparative Examples 1 to 3 were tried every night. Specifically, the first group tried the hydrogel Chinese medicine eye patch prepared in Example 1, the second group tried the hydrogel Chinese medicine eye patch prepared in Example 2, the third group tried the hydrogel Chinese medicine eye patch prepared in Example 3, the fourth group tried the hydrogel Chinese medicine eye patch prepared in Example 4, and the fifth group tried the hydrogel Chinese medicine eye patch prepared in Example 5. The hydrogel Chinese medicine eye patch prepared in Example 5, the sixth group tried the hydrogel Chinese medicine eye patch prepared in Comparative Example 1, the seventh group tried the hydrogel Chinese medicine eye patch prepared in Comparative Example 2, and the eighth group tried the hydrogel Chinese medicine eye patch prepared in Comparative Example 3. After the test, each group evaluated the tried Chinese medicine eye patch from three aspects: whether it can effectively relieve eye fatigue, improve eyesight and calm the mind, and other sensory evaluations. Among them, the other sensory evaluation refers to a comprehensive score of the smell, applicability, permeability and toughness of the hydrogel eye patch, with a full score of 100 points. The results are shown in Table 1.

[0101] Table 1 Efficacy and sensory evaluation of hydrogel Chinese medicine eye patch

[0102] Group Relieve eye fatigue Improves eyesight and calms nerves Other sensory evaluation scores Group 1 Good results Good results 84 Group 2 Excellent results Excellent results 93 Group 3 Good results Good results 83 Group 4 Good results Excellent results 90 Group 5 Good results Good results 85 Comparative Example 1 Good results Good results 76 Comparative Example 2 Poor effect Poor effect 65 Comparative Example 3 Poor effect Good results 73

[0103] As can be seen from Table 1, the hydrogel Chinese medicine eye patches prepared in Examples 1 to 5 all have the effects of improving eyesight, calming the nerves and relieving eye fatigue, and the efficacy and other sensory evaluations of the hydrogel Chinese medicine eye patches prepared in Example 2 are the best, indicating that the different compounding ratios of the components in the effective ingredients of Chinese medicine and the mass ratios of the raw materials required to prepare the hydrogel have an impact on the efficacy and performance of the eye patches; at the same time, overall, the efficacy and sensory evaluation of the hydrogel eye patches prepared in Comparative Examples 1 to 3 are lower than those of the hydrogel eye patches prepared in Examples 1 to 5, because: the content of the effective ingredients of Chinese medicine in Comparative Example 1 is too much, resulting in a strong smell of the eye patch and a low sensory evaluation score; the content of sodium alginate in Comparative Example 2 is relatively high, resulting in the prepared phase A solution being too thick, so that the effective ingredients of Chinese medicine cannot be evenly dispersed, and thus cannot be absorbed by the eye tissue; in the cross-linking process between the calcium chloride solution and the hydrogel in Comparative Example 3, due to the high concentration of the calcium chloride solution, the colloid is excessively plastic, the colloid becomes hard, the effective ingredients cannot be effectively released, and the applicability is poor.

Claims

1. A method for preparing a hydrogel Chinese medicine eye patch for improving eyesight, calming the nerves and relieving eye fatigue, characterized in that: The steps include: Step 1: Extract the active ingredients of traditional Chinese medicine Step 1.1, weigh 2-10g of Forsythia suspensa, 5-15g of Ligustrum lucidum fruit, 3-10g of chamomile flower, 3-10g of mulberry leaf, 1-5g of mint, 3-10g of Radix Rehmanniae, 2-12g of Prunella vulgaris, 1-8g of Semen Ziziphi spinulosae and 2-10g of Polygala tenuifolia, mix and obtain a Chinese medicine raw material; Step 1.2, first add the Chinese medicine raw materials into a round-bottom flask, then add 20 to 40 times the weight of the Chinese medicine raw materials into the round-bottom flask. Boil, cool to room temperature, filter, and collect the liquid medicine; Step 1.3, concentrating the medicinal liquid and sterilizing it at high temperature, and after cooling naturally, obtaining the effective ingredients of the traditional Chinese medicine, and refrigerating them for later use; Step 2: Preparation of hydrogel Step 2.1, weigh 1-3 g of powdered sodium alginate, add it to 60-130 times of its weight of water, heat and stir to fully dissolve it, and obtain a phase A solution; Step 2.2, weigh 5-15 g of gelatin, 0.1-1 g of methylparaben and 2-10 g of glycerol, add them to water 3-10 times the weight of the total of gelatin, methylparaben and glycerol, heat and stir until there are no transparent particles, to obtain a mixed solution, then add 1-4 g of sorbitol to the mixed solution, continue heating and stirring to fully dissolve it, to obtain a phase B solution; Step 2.3, firstly allowing the phase A solution and the phase B solution to stand separately, then mixing the phase A solution and the phase B solution, stirring to make them evenly mixed, to obtain a hydrogel; Step 3: Preparation of hydrogel Chinese medicine eye patch Step 3.1, adding the effective ingredients of traditional Chinese medicine to the hydrogel according to the mass ratio of (5-20):100, stirring evenly, to obtain a hydrogel containing the effective ingredients of traditional Chinese medicine; Step 3.2: Pour the hydrogel containing the effective ingredients of traditional Chinese medicine into the eye patch mold, and after it stops flowing, drop 10% to 20% of its weight and a cross-linker solution with a concentration of 1wt% to 1.5wt%, let it stand at 4°C for 2 to 6 hours, and demold to obtain the hydrogel traditional Chinese medicine eye patch.

2. The method for preparing the hydrogel Chinese medicine eye patch for improving eyesight, calming nerves and relieving eye fatigue according to claim 1, characterized in that: The decoction process in step 1.2 is as follows: firstly, heat the round-bottom flask containing the Chinese medicine raw materials and water at 90-95° C., and after the water boils, switch to 55-65° C. and heat for 1.5-3 hours.

3. The method for preparing the hydrogel Chinese medicine eye patch for improving eyesight, calming nerves and relieving eye fatigue according to claim 1, characterized in that: The room temperature of step 1.2 is 20-30°C.

4. The method for preparing the hydrogel Chinese medicine eye patch for improving eyesight, calming nerves and relieving eye fatigue according to claim 1, characterized in that: The concentration in step 1.3 is carried out by using a rotary evaporator at 60° C. and a rotation speed of 50 rpm for 1 to 3 hours to concentrate the drug solution to 1 / 6 to 1 / 4 of its original volume.

5. The method for preparing the hydrogel Chinese medicine eye patch for improving eyesight, calming nerves and relieving eye fatigue according to claim 1, characterized in that: The high temperature sterilization in step 1.3 is performed at 110-125° C. for 15-25 minutes.

6. The method for preparing the hydrogel Chinese medicine eye patch for improving eyesight, calming nerves and relieving eye fatigue according to claim 1, characterized in that: The heating temperature in step 2.1 is 55-58°C.

7. The method for preparing the hydrogel Chinese medicine eye patch for improving eyesight, calming nerves and relieving eye fatigue according to claim 1, characterized in that: The heating temperature in step 2.2 is 58-70°C.

8. The method for preparing the hydrogel Chinese medicine eye patch for improving eyesight, calming nerves and relieving eye fatigue according to claim 1, characterized in that: The step 2.3 of standing is to place the phase A solution and the phase B solution in a water bath at 60° C. respectively and stand for 10 minutes.

9. The method for preparing the hydrogel Chinese medicine eye patch for improving eyesight, calming nerves and relieving eye fatigue according to claim 1, characterized in that: In step 3.2, the crosslinking agent solution is a calcium chloride solution or a calcium lactate solution.

10. A hydrogel Chinese medicine eye patch for improving eyesight, calming nerves and relieving eye fatigue, prepared by the method according to any one of claims 1 to 9.

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